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https://www.readbyqxmd.com/read/28445869/silicone-oil-related-visual-loss
#1
Hamouda Hamdy Ghoraba, Adel Galal Zaky, Mohamed Amin Heikal, Emad Eldin Mohamed Elgemai, Haithem Mamoun Abd Al Fatah
BACKGROUND: Silicone oil (SO) is used as an intravitreal tamponade agent in vitreoretinal surgery for rhegmatogenous retinal detachment (RRD) complicated by proliferative vitreoretinopathy or with large, multiple retinal tears. Usually, SO is left in the eye for at least 3 months. Although its use can lead to well-known complications, intraocular SO is generally well tolerated. Some studies have reported unexpected central vision loss after SO use or removal. OBJECTIVE: To investigate and analyze the reason for visual loss after the use or removal of intraocular SO in patients who underwent vitrectomy surgeries for RRD...
April 27, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28445192/one-year-clinical-outcomes-of-a-corneal-inlay-for-presbyopia
#2
Sandra M C Beer, Rodrigo Santos, Eliane M Nakano, Flavio Hirai, Enrico J Nitschke, Claudia Francesconi, Mauro Campos
PURPOSE: To report the results of a 1-year follow-up analysis of the safety and efficacy of the Flexivue Microlens corneal inlay. METHODS: The Flexivue Microlens corneal inlay was implanted in the nondominant eye of patients with emmetropic presbyopia (a spherical equivalent of -0.5 to 1.00 diopter) after the creation of a 300-μm deep stromal pocket, using a femtosecond laser. The patients were followed up according to a clinical protocol involving refraction, anterior segment imaging analysis (Oculyzer), and optical quality analysis (OPD-Scan)...
April 25, 2017: Cornea
https://www.readbyqxmd.com/read/28443810/-transient-monocular-vision-loss
#3
E J Volkers, R C J M Donders, A Algra, L J Kapelle
Transient monocular vision loss (TMVL) caused by temporary disturbance of blood flow to the retina is a harbinger of future vascular complications. The diagnosis may be difficult, not only because it is solely dependent on history taking, but also because the range of monocular visual symptoms a patient may experience is wide. The classic pattern of a sudden black or grey visual field, or a curtain that is drooping in front of one eye, easily fits in the diagnosis of TMVL; however, coloured vision or flashes should not always be considered as benign...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28442697/when-should-we-give-up-filtration-surgery-indications-techniques-and-results-of-cyclodestruction
#4
Marisse Masis Solano, Guofu Huang, Shan C Lin
PURPOSE: Cyclodestructive procedures are traditionally used in cases of glaucoma that are refractory to medical and surgical therapy. The goal of this chapter is to describe the indications, contraindications, techniques, and pitfalls of cyclodestructive procedures, including transscleral cyclophotocoagulation (TCP), micropulse TCP (MP-TCP), endoscopic cyclophotocoagulation (ECP), and ultrasound cilioplasty. METHODS: A literature search for cyclodestructive techniques was performed, and relevant studies were included for evaluation and review...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28442266/cln5-is-cleaved-by-members-of-the-spp-sppl-family-to-produce-a-mature-soluble-protein
#5
Felix Jules, Etienne Sauvageau, Karine Dumaresq-Doiron, Javier Mazzaferri, Martina Haug-Kröper, Regina Fluhrer, Santiago Costantino, Stephane Lefrancois
The Neuronal ceroid lipofuscinoses (NCLs) are a group of recessive disorders of childhood with overlapping symptoms including vision loss, ataxia, cognitive regression and premature death. 14 different genes have been linked to NCLs (CLN1-CLN14), but the functions of the proteins encoded by the majority of these genes have not been fully elucidated. Mutations in the CLN5 gene are responsible for the Finnish variant late-infantile form of NCL (Finnish vLINCL). CLN5 is translated as a 407 amino acid transmembrane domain containing protein that is heavily glycosylated, and subsequently cleaved into a mature soluble protein...
April 22, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28440252/adjustment-to-acquired-vision-loss-in-adults-presenting-for-visual-disability-certification
#6
Aditya Nakade, Jolly Rohatgi, Manjeet S Bhatia, Upreet Dhaliwal
CONTEXT: Rehabilitation of the visually disabled depends on how they adjust to loss; understanding contributing factors may help in effective rehabilitation. AIM: The aim of this study is to assess adjustment to acquired vision loss in adults. SETTINGS AND DESIGN: This observational study, conducted in the Department of Ophthalmology at a tertiary-level teaching hospital, included thirty persons (25-65 years) with <6/60 in the better eye, and vision loss since ≥6-months...
March 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28440245/pluripotent-stem-cells-a-therapeutic-source-for-age-related-macular-degeneration
#7
REVIEW
Sowmya Parameswaran, Subramanian Krishnakumar
Age-related macular degeneration (AMD) leads to progressive loss of central vision in the elderly. At a cellular level, there is aging of the retinal pigment epithelial (RPE) cells, and accumulation of lipofuscin that interferes with the proper functioning of RPE which eventually leads to apoptosis. Treatment depends on the stage of the disease. Wet AMD which has neovascularization is managed by local therapies such as laser photocoagulation and photodynamic therapy and is managed with injections of antivascular endothelial growth factor-based therapy...
March 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28440088/head-and-neck-giant-cell-arteritis-an-autoimmune-disease-with-many-faces
#8
Markus Wirth, Lucas Schirmer, Benedikt Hofauer, Magdalena Lenschow, Daria Loos, Klaus Thuermel, Andreas Knopf
CONCLUSION: A high rate of infrequent presentations of giant cell arteritis were seen in the ENT department and should be anticipated as a differential diagnosis in every older patient with odynophagia with high CRP values without cause in thorough ENT examination. OBJECTIVE: To describe the clinical manifestation of head and neck giant cell arteritis and to derive a diagnostic pathway covering atypical cases. METHOD: Single-center, retrospective analysis of cases with GCA in the head and neck region (HN-GCA) (2002-2012) to describe the clinical presentation and to derive a diagnostic pathway covering manifestations presenting to an ENT department...
April 25, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28439944/using-perimetric-data-to-estimate-ganglion-cell-loss-for-detecting-progression-of-glaucoma-a-comparison-of-models
#9
Derek A Price, William H Swanson, Douglas G Horner
PURPOSE: Models relating perimetric sensitivities to ganglion cell numbers have been proposed for combining structural and functional measures from patients with glaucoma. Here we compared seven models for ability to differentiate progressing and stable patients, testing the hypothesis that the model incorporating local spatial scale would have the best performance. METHODS: The models were compared for the United Kingdom Glaucoma Treatment Study (UKGTS) data for the right eyes of 489 patients recently diagnosed with glaucoma...
April 25, 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28437797/central-and-peripheral-vision-for-scene-recognition-a-neurocomputational-modeling-exploration
#10
Panqu Wang, Garrison W Cottrell
What are the roles of central and peripheral vision in human scene recognition? Larson and Loschky (2009) showed that peripheral vision contributes more than central vision in obtaining maximum scene recognition accuracy. However, central vision is more efficient for scene recognition than peripheral, based on the amount of visual area needed for accurate recognition. In this study, we model and explain the results of Larson and Loschky (2009) using a neurocomputational modeling approach. We show that the advantage of peripheral vision in scene recognition, as well as the efficiency advantage for central vision, can be replicated using state-of-the-art deep neural network models...
April 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28437352/effect-and-strategy-of-1-stage-interrupted-2-level-transpedicular-wedge-osteotomy-for-correcting-severe-kyphotic-deformities-in-ankylosing-spondylitis
#11
Yongfei Zhao, Yan Wang, Zheng Wang, Xuesong Zhang, Keya Mao, Yonggang Zhang
STUDY DESIGN: Prospective study. OBJECTIVE: To investigate the safety, outcome, and strategy of the 1-stage interrupted 2-level transpedicular wedge osteotomy for correcting the severe kyphotic deformity in ankylosing spondylitis (AS). SUMMARY OF BACKGROUND DATA: There has been a large series in the literature reporting on results of osteotomy for the correction of kyphotic deformity secondary to AS. However, few articles have reported, in detail, the plan, design, strategy, and effect of 1-stage interrupted 2-level transpedicular wedge osteotomy for the correction of severe kyphotic deformity in AS...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28437265/unilateral-blindness-after-septoplasty
#12
Ahmet Erdem Kilavuz, Duzgun Yildirim, Gediz Murat Serin, Asim Kaytaz
Septoplasty is a frequently performed procedure with mostly minor complications. Nevertheless, it may lead to serious complications.The authors present a 29-year-old patient admitted to their hospital 10 days after septoplasty in another institution. He suffered a total loss of vision immediately after the surgery.High-resolution computed tomography and magnetic resonance imaging revealed a direct trauma of the optic canal and an inflamed and edematous optic nerve. Even though a successful endoscopic optic nerve was performed, the patient's loss of vision did not improve after the surgery...
April 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28437176/echinocandins-in-ocular-therapeutics
#13
Akash Patil, Soumyajit Majumdar
Fungal infections of the eye, especially fungal keratitis and endophthalmitis, are major causes of concern and if left untreated could lead to vision loss. Currently, natamycin (polyene antifungal) is the only commercially available topical agent used for the treatment of ocular fungal infections. The other antifungals, belonging to the polyene and azole classes, are used off-label in treating ocular infections and are administered topically, orally, intraocularly, or systemically. Even though their use through the different routes of administration has shown favorable outcomes, challenges such as poor ocular penetration, low bioavailability, ocular toxicity, and systemic side effects limit their utility...
February 24, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28436035/nap-counteracts-hyperglycemia-hypoxia-induced-retinal-pigment-epithelial-barrier-breakdown-through-modulation-of-hifs-and-vegf-expression
#14
Agata Grazia D'Amico, Grazia Maugeri, Daniela Maria Rasà, Valentina La Cognata, Salvatore Saccone, Concetta Federico, Sebastiano Cavallaro, Velia D'Agata
Diabetic macular edema (DME) is a common complication leading to a central vision loss in patients with diabetes. In this eye pathology, the hyperglycaemic/hypoxic microenvironment of pigmented epithelium is responsible for outer blood retinal barrier integrity changes. More recently, we have shown that a small peptide derived from the activity-dependent neuroprotective protein (ADNP), known as NAP, counteracts damages occurring during progression of diabetic retinopathy by modulating HIFs/VEGF pathway. Here, we have investigated for the first time the role of this peptide on outer blood retinal barrier (BRB) integrity exposed to hyperglycaemic/hypoxic insult mimicking a model in vitro of DME...
April 24, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28435219/clinical-effectiveness-of-currently-available-low-vision-devices-in-glaucoma-patients-with-moderate-to-severe-vision-loss
#15
Yogesh Patodia, Elizabeth Golesic, Alex Mao, Cindy Ml Hutnik
PURPOSE: The aim of this trial is to study the effectiveness of currently available low-vision devices in glaucoma patients with moderate-to-severe vision loss. DESIGN: This is a randomized pilot clinical trial. PARTICIPANTS: Sixteen low-vision glaucoma patients participated in this study. METHODS: Patients with a best-corrected visual acuity between 20/70 and 20/400 in the better eye and a diagnosis of stable primary or secondary open-angle glaucoma were randomized to a low-vision treatment group or a nonintervention control group...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28434070/subconjunctival-hemorrhage-and-vision-loss-after-regional-ocular-anesthesia
#16
Umesh Chandra Behera, Lapam Panda, Sumi Gupta, Rohit Ramesh Modi
PURPOSE: To report two cases of retinal vascular occlusion and associated subconjunctival hemorrhage in needle optic nerve injury during local bulbar anesthesia. METHODS: Surgical records of these two subjects who presented with acute vision loss after cataract extraction were studied, and systemic workup and ocular imaging were carried out to establish the cause. RESULTS: Computerized tomography showed evidence of optic nerve injury. CONCLUSION: Subconjunctival hemorrhage could be an associated clinical finding in hypodermic needle injury-related retinal vascular occlusion during ocular anesthesia...
April 22, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28433576/proptosis-and-vision-loss-as-grave-complications-of-allergic-fungal-sinusitis-and-polyposis
#17
Shane A Bobart, Ves Dimov, Darby Sider, Esteban Gallego
No abstract text is available yet for this article.
April 19, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28433204/-post-operative-visual-loss-after-cervical-laminectomy-in-prone-position
#18
Kumar Naren Chandra, Meghraj Kundan
Postoperative visual loss is a rare and devastating complication. The estimated incidence is 0.01-1% after non ocular surgery. It has been reported after spine, cardiac and head and neck surgeries. We report a patient who was operated for cervical laminectomy in prone position and complained of loss of vision in one eye postoperatively. He was thoroughly investigated after visual loss. The case was diagnosed as central retinal artery occlusion (CRAO) of the left eye. Here we consider the potential etiological factors causing this unilateral loss of vision and try to suggest strategies to reduce the incidence of the complication in spinal surgery...
April 19, 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/28432165/intravitreal-cysticercosis-with-full-thickness-macular-hole-management-outcome-and-intraoperative-optical-coherence-tomography-features
#19
Karthikeya R, Raghav Dinesh Ravani, Prateek Kakkar, Atul Kumar
Ocular cysticercosis is a serious condition with a potential for complete vision loss if left untreated. Intravitreal cysticercosis is the most common ocular form of cysticercosis and is associated with retinal detachment, retinal traction, subretinal scarring and vitritis. To the best of our knowledge, there is no report of the occurrence of a live intravitreal cysticercosis with a full thickness macular hole (FTMH) in the literature. We here report a case of live intravitreal cysticercosis with a FTMH along with its management and intraoperative optical coherence tomography features of the live cysticercus...
April 21, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28432112/reduction-of-severe-visual-loss-and-complications-following-intra-arterial-chemotherapy-iac-for-refractory-retinoblastoma
#20
M Ashwin Reddy, Zishan Naeem, Catriona Duncan, Fergus Robertson, Jane Herod, Adam Rennie, Alki Liasis, Dorothy Ann Thompson, Mandeep Sagoo
BACKGROUND: Intra-arterial chemotherapy (IAC) for retinoblastoma has been documented as causing visual loss and ocular motility problems. A lack of safety data has precluded its acceptance in all centres. METHODS: Retrospective cohort study of patients with retinoblastoma from 2013 to 2015 who had a healthy foveola and relapsed following systemic chemotherapy. All required IAC. The correlation of complications with doses of melphalan +/- topotecan used and putative catheterisation complications was assessed...
April 21, 2017: British Journal of Ophthalmology
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