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https://www.readbyqxmd.com/read/29230267/presenting-signs-of-retinoblastoma-at-a-tertiary-level-teaching-hospital-in-ethiopia
#1
Jemal Zeberga Shifa, Alemayehu Mekonnen Gezmu
Introduction: Retinoblastoma is a primary malignant intraocular neoplasm that arise from immature retinoblasts with in developing retina. The commonest presenting sign in developing country is proptosis which is the late presenting sign. We report presenting signs of retinoblastoma in Ethiopian children seen at a tertiary level teaching hospitals in Ethiopia. Methods: Prospective case series study was done on children who presented with retinoblastoma between May 1, 2005 and September 1, 2006...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29229690/clinical-reasoning-monocular-vision-loss-ophthalmoplegia-and-strokes-in-a-61-year-old-man-with-diabetes-mellitus
#2
Guillaume Lamotte, Zehra Farzal, William Denney Zimmerman, Suhua Han, Pedro de Brito, Douglas Mayson
No abstract text is available yet for this article.
December 12, 2017: Neurology
https://www.readbyqxmd.com/read/29229653/investigation-of-time-to-first-presentation-and-extrahospital-factors-in-the-treatment-of-neovascular-age-related-macular-degeneration-a-retrospective-cross-sectional-study
#3
Peng Yong Sim, Sonul Gajree, Baljean Dhillon, Shyamanga Borooah
OBJECTIVES: To assess the time from symptom onset to treatment for neovascular age-related macular degeneration (nvAMD) and to measure the awareness of AMD in Southeast Scotland. DESIGN: Retrospective cross-sectional study. SETTING: Secondary care, Southeast of Scotland. METHODS: Patients treated with intravitreal therapy (IVT) for nvAMD in Southeast Scotland between 2013 and 2015 were identified using a treatment register...
December 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/29228813/atypical-location-of-unusual-supratentorial-neurenteric-cyst-a-case-report
#4
Ramanadha Reddy, Mahesh Kumar, Suchanda Bhattacharjee
We report a case of a right anterior clinoid process (ACP) neurenteric cyst which presented with gradual impairment of vision in the right eye. Imaging suggested an infective cystic lesion. In view of rapid visual loss urgent surgery was conducted. Erosion of the ACP was found from where white mucus like material was aspirated. The cyst wall was completely excised. Immunohistochemistry indicated an endodermal origin of the cyst.
December 11, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29227886/traveling-with-blindness-a-qualitative-space-time-approach-to-understanding-visual-impairment-and-urban-mobility
#5
Sandy Wong
This paper draws from H├Ągerstrand's space-time framework to generate new insights on the everyday mobilities of individuals with visual impairments in the San Francisco Bay Area. While existing research on visual impairment and mobility emphasizes individual physical limitations resulting from vision loss or inaccessible public spaces, this article highlights and bridges both the behavioral and social processes that influence individual mobility. A qualitative analysis of sit-down and mobile interview data reveals that the space-time constraints of people with visual impairments are closely linked to their access to transportation, assistive technologies, and mobile devices...
December 8, 2017: Health & Place
https://www.readbyqxmd.com/read/29227822/automated-retinal-health-diagnosis-using-pyramid-histogram-of-visual-words-and-fisher-vector-techniques
#6
Joel E W Koh, Eddie Y K Ng, Sulatha V Bhandary, Yuki Hagiwara, Augustinus Laude, U Rajendra Acharya
Untreated age-related macular degeneration (AMD), diabetic retinopathy (DR), and glaucoma may lead to irreversible vision loss. Hence, it is essential to have regular eye screening to detect these eye diseases at an early stage and to offer treatment where appropriate. One of the simplest, non-invasive and cost-effective techniques to screen the eyes is by using fundus photo imaging. But, the manual evaluation of fundus images is tedious and challenging. Further, the diagnosis made by ophthalmologists may be subjective...
December 5, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29227295/an-unusual-presentation-of-pituitary-gland-apoplexy-with-noninfectious-meningitis
#7
Margaret LaPorte, Jenna Pollock, Michael Ward, James Fulcher
Pituitary adenomas make up 10% of intracranial tumors, but because of their location, they may go undetected for long periods. In this article, we report the case of a 68-year-old white man found deceased in his residence, who died of acute pituitary tumor apoplexy. He was known to have severe symptoms including acute headache, vision loss, and altered behavior. When found, his home was in extreme disarray, mimicking a possible assault. At autopsy, the decedent had multiple superficial abrasions about the upper and lower extremities, as well as a 2...
December 7, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/29225928/causes-of-severe-visual-impairment-and-blindness-in-students-in-schools-for-the-blind-in-northwest-ethiopia
#8
Mulusew Asferaw, Geoffrey Woodruff, Clare Gilbert
Objectives: To determine the causes of severe visual impairment and blindness (SVI/BL) among students in schools for the blind in Northwest Ethiopia and to identify preventable and treatable causes. Method: Students attending nine schools for the blind in Northwest Ethiopia were examined and causes assigned using the standard WHO record form for children with blindness and low vision in May and June 2015. Results: 383 students were examined, 357 (93%) of whom were severely visually impaired or blind (<6/60 in their better eye)...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29225150/decellularised-conjunctiva-for-ocular-surface-reconstruction
#9
Joana Witt, Sonja Mertsch, Maria Borrelli, Jana Dietrich, Gerd Geerling, Stefan Schrader, Kristina Spaniol
Conjunctival reconstruction is an integral component of ocular surface restoration. Decellularised tissues are frequently used clinically for tissue engineering. This study identifies porcine decellularised conjunctiva (PDC) and human decellularised conjunctiva (HDC) as promising substitutes for conjunctival reconstruction. PDC and HDC were nearly DNA-free, structurally intact and showed no cytotoxic effects in vitro, which was confirmed by DNA quantification, histology, transmission electron microscopy, collagen quantification and cytotoxicity assay...
December 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29223681/language-processing-in-age-related-macular-degeneration-associated-with-unique-functional-connectivity-signatures-in-the-right-hemisphere
#10
Jie Zhuang, David J Madden, Xuan Duong-Fernandez, Nan-Kuei Chen, Scott W Cousins, Guy G Potter, Michele T Diaz, Heather E Whitson
Age-related macular degeneration (AMD) is a retinal disease associated with significant vision loss among older adults. Previous large-scale behavioral studies indicate that people with AMD are at increased risk of cognitive deficits in language processing, particularly in verbal fluency tasks. The neural underpinnings of any relationship between AMD and higher cognitive functions, such as language processing, remain unclear. This study aims to address this issue using independent component analysis of spontaneous brain activity at rest...
November 14, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29222569/acute-monocular-vision-loss-in-a-young-adult
#11
Menachem Y Weiss, Ajay E Kuriyan
No abstract text is available yet for this article.
December 7, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29219932/cuticular-drusen-in-an-indigenous-australian
#12
William J Cunningham, Chandrakumar Balaratnasingam, Yi Chen, Fred K Chen
BACKGROUND/PURPOSE: To report a case of cuticular drusen in an indigenous Australian. METHODS: A 37-year-old indigenous (aboriginal) Australian woman from a remote Western Australian town presented with a 2-month history of vision loss. Clinical history, examination, and multimodal retinal imaging data from spectral domain optical coherence tomography, fundus autofluorescence, fluorescein angiography, and indocyanine green angiography were analyzed. RESULTS: Multimodal imaging confirmed cuticular drusen complicated by a right choroidal neovascularization with pigment epithelial detachment and a left foveal vitelliform lesion...
December 5, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29218670/systematic-review-of-robotic-low-anterior-resection-for-rectal-cancer
#13
Christoph Holmer, Martin E Kreis
BACKGROUND: Potential advantages of robotic surgery, such as 3-dimensional high-definition vision, wrist-like movements of instruments, stable camera holding, motion filter for tremor-free surgery, and improved ergonomics, may provide better clinical, oncological, and functional outcomes in rectal cancer surgery, as suggested in many comparative studies. However, there has not been a systematic review specific to LAR/TME for rectal cancer that includes both robotic versus laparoscopic and robotic versus open comparative studies...
December 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29218308/opportunities-for-crispr-cas9-gene-editing-in-retinal-regeneration-research
#14
REVIEW
Leah J Campbell, David R Hyde
While retinal degeneration and disease results in permanent damage and vision loss in humans, the severely damaged zebrafish retina has a high capacity to regenerate lost neurons and restore visual behaviors. Advancements in understanding the molecular and cellular basis of this regeneration response give hope that strategies and therapeutics may be developed to restore sight to blind and visually-impaired individuals. Our current understanding has been facilitated by the amenability of zebrafish to molecular tools, imaging techniques, and forward and reverse genetic approaches...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29217756/light-focusing-human-micro-lenses-derived-from-zebrafish-like-lens-cell-masses-model-lens-development-and-drug-induced-cataract-in-vitro
#15
Patricia Murphy, Md Humayun Kabir, Tarini Srivastava, Michele E Mason, Chitra Umala Dewi, Seakcheng Lim, Andrian Yang, Djordje Djordjevic, Murray C Killingsworth, Joshua W K Ho, David G Harman, Michael D O'Connor
Cataracts cause vision loss and blindness by impairing the ability of the ocular lens to focus light onto the retina. Various cataract risk factors have been identified including drug treatments, age, smoking, and diabetes. However, the molecular events responsible for these different forms of cataract are ill-defined, and the advent of modern cataract surgery in the 1960s virtually eliminated access to human lenses for research. Here we demonstrate large-scale production of light-focusing human micro-lenses from spheroidal masses of human lens epithelial cells purified from differentiating pluripotent stem cells...
December 7, 2017: Development
https://www.readbyqxmd.com/read/29212712/a-reversible-thermoresponsive-sealant-for-temporary-closure-of-ocular-trauma
#16
Niki Bayat, Yi Zhang, Paulo Falabella, Roby Menefee, John J Whalen, Mark S Humayun, Mark E Thompson
Open globe injuries are full-thickness injuries sustained to the eye wall (cornea or sclera), which cause immediate drops in intraocular pressure that may lead to retinal detachment and permanent vision loss if not treated rapidly after injury. The current standard of care for open globe injuries consists of suturing the margins closed, but the technique can be time-consuming, requires specialized training and equipment, and can lead to patient discomfort, abrasion, and infection from eye rubbing. We engineered an injectable, thermoresponsive sealant (TRS) and a custom tool to occlude open globe injuries...
December 6, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29212538/a-pilot-investigation-of-audiovisual-processing-and-multisensory-integration-in-patients-with-inherited-retinal-dystrophies
#17
Mark H Myers, Alessandro Iannaccone, Gavin M Bidelman
BACKGROUND: In this study, we examined audiovisual (AV) processing in normal and visually impaired individuals who exhibit partial loss of vision due to inherited retinal dystrophies (IRDs). METHODS: Two groups were analyzed for this pilot study: Group 1 was composed of IRD participants: two with autosomal dominant retinitis pigmentosa (RP), two with autosomal recessive cone-rod dystrophy (CORD), and two with the related complex disorder, Bardet-Biedl syndrome (BBS); Group 2 was composed of 15 non-IRD participants (controls)...
December 7, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29212484/clinical-features-of-visual-disturbances-secondary-to-isolated-sphenoid-sinus-inflammatory-diseases
#18
Lanlan Chen, Libin Jiang, Bentao Yang, Prem S Subramanian
BACKGROUND: Visual disturbances associated with isolated sphenoid sinus inflammatory diseases (ISSIDs) are easily misdiagnosed due to the nonspecific symptoms and undetectable anatomical location. The main objective of this retrospective case series is to investigate the clinical features of visual disturbances secondary to ISSIDs. METHODS: Clinical data of 23 patients with unilateral or bilateral visual disturbances secondary to ISSIDs from 2004 to 2014 with new symptoms were collected...
December 6, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29212481/early-anti-vegf-treatment-for-hemorrhagic-occlusive-retinal-vasculitis-as-a-complication-of-cataract-surgery
#19
Konstantinos Andreanos, Petros Petrou, George Kymionis, Dimitrios Papaconstantinou, Ilias Georgalas
BACKGROUND: We report a case of hemorrhagic occlusive retinal vasculitis (HORV) after prophylactic intracameral vancomycin use during an uneventful cataract surgery treated with early anti-VEGF treatment. CASE PRESENTATION: A 51-year-old female underwent uneventful cataract surgery with prophylactic intracameral vancomycin during the procedure. On the seventh post-operative-day, she presented with sudden painful, visual loss. Fundus examination revealed peripheral hemorrhagic retinal vasculitis...
December 6, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29212048/electroclinical-features-of-epilepsy-associated-with-1p36-deletion-syndrome-a-review
#20
REVIEW
M Greco, P Ferrara, G Farello, P Striano, A Verrotti
1p36 terminal deletion is a recently recognized syndrome with multiple congenital anomalies and intellectual disability. It occurs approximately in 1 out of 5000 to 10,000 live births and is the most common subtelomeric microdeletion observed in human. Medical problems commonly caused by terminal deletions of 1p36 include developmental delay, intellectual disability, seizures, vision problems, hearing loss, short stature, brain anomalies, congenital heart defects, cardiomyopathy, renal anomalies and distinctive facial features...
December 2, 2017: Epilepsy Research
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