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https://www.readbyqxmd.com/read/29244956/effects-of-carbohydrate-and-branched-chain-amino-acid-beverage-ingestion-during-acute-upper-body-resistance-exercise-on-performance-and-post-exercise-hormone-response
#1
JohnEric W Smith, Ben M Krings, Brandon D Shepherd, Hunter S Waldman, Steven A Basham, Matthew J McAllister
The purpose of this investigation was to examine the individual and combined effects of ingesting carbohydrates (CHO) and branched chain amino acids (BCAA) during high volume upper-body resistance exercise (RE) on markers of catabolism and performance. Thirteen resistance trained males completed four experimental trials with supplementation ingesting beverages containing CHO, BCAA, CHO+BCAA, or placebo (PLA) in a randomized, double-blind design. The beverages were ingested in 118 mL servings six times during a ~60 min RE session consisting of bench press, bent-over row, incline press, and close-grip row...
December 15, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29244893/effectiveness-of-intra-articular-injections-of-sodium-hyaluronate-or-corticosteroids-for-intracapsular-temporomandibular-disorders-a-systematic-review-and-meta-analysis
#2
Marlon A Moldez, Victor R Camones, Guillermo E Ramos, Mariela Padilla, Reyes Enciso
AIMS: To assess the effectiveness of intra-articular injections of sodium hyaluronate (NaH) or corticosteroids (CS) for treatment of intracapsular temporomandibular disorders (TMD). METHODS: Single- or double-blinded randomized controlled trials (RCTs) on the effectiveness of NaH or CS injections, compared to each other or to placebo, for the treatment of intracapsular TMD due to osteoarthritis and/or internal joint derangement were analyzed in this systematic review and meta-analysis...
December 15, 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29244850/intensity-matters-therapist-dependent-dose-of-spinal-transcutaneous-electrical-nerve-stimulation
#3
Diego Serrano-Muñoz, Julio Gómez-Soriano, Elisabeth Bravo-Esteban, María Vázquez-Fariñas, Julian Taylor, Juan Avendaño-Coy
The intensity used during transcutaneous electrical nerve stimulation (TENS) in both, clinical practice and research studies, is often based on subjective commands such as "strong but comfortable sensation". There is no consensus regarding the effectiveness dose of TENS. The objective was to determine the difference in the effect of spinal TENS on soleus H-reflex modulation when applied by two therapists instructed to apply the stimulation at a "strong but comfortable" intensity. Twenty healthy volunteers divided into two groups: Therapist 1 (n = 10) and Therapist 2 (n = 10)...
2017: PloS One
https://www.readbyqxmd.com/read/29244743/hematological-and-hemodynamic-responses-to-acute-and-short-term-creatine-nitrate-supplementation
#4
Ryan L Dalton, Ryan J Sowinski, Tyler J Grubic, Patrick B Collins, Adriana M Coletta, Aimee G Reyes, Brittany Sanchez, Majid Koozehchian, Yanghoon P Jung, Christopher Rasmussen, Mike Greenwood, Peter S Murano, Conrad P Earnest, Richard B Kreider
In a double-blind, crossover, randomized and placebo-controlled trial; 28 men and women ingested a placebo (PLA), 3 g of creatine nitrate (CNL), and 6 g of creatine nitrate (CNH) for 6 days. Participants repeated the experiment with the alternate supplements after a 7-day washout. Hemodynamic responses to a postural challenge, fasting blood samples, and bench press, leg press, and cycling time trial performance and recovery were assessed. Data were analyzed by univariate, multivariate, and repeated measures general linear models (GLM)...
December 15, 2017: Nutrients
https://www.readbyqxmd.com/read/29244522/pulmonary-vasodilator-therapy-in-shock-associated-cardiac-arrest
#5
Ryan W Morgan, Robert M Sutton, Michael Karlsson, Andrew J Lautz, Constantine D Mavroudis, William P Landis, Yuxi Lin, Sejin Jeong, Nancy Craig, Vinay M Nadkarni, Todd J Kilbaugh, Robert A Berg
RATIONALE: Many in-hospital cardiac arrests are precipitated by hypotension, often associated with systemic inflammation. These patients are less likely to be successfully resuscitated and novel approaches to their treatment are needed. OBJECTIVES: To determine if the addition of inhaled nitric oxide (iNO) to hemodynamic-directed cardiopulmonary resuscitation (HD-CPR) would improve short-term survival from cardiac arrest associated with shock and systemic inflammation...
December 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29244126/silent-cerebral-small-vessel-disease-twice-as-prevalent-in-middle-aged-well-controlled-cart-treated-hiv-infected-individuals-than-hiv-uninfected-individuals
#6
Antoine Moulignier, Julien Savatovsky, Lambert Assoumou, François-Xavier Lescure, Cédric Lamirel, Ophelia Godin, Nadia Valin, Roland Tubiana, Ana Canestri, Pascal Roux, Jean-Claude Sadik, Laurence Salomon, Marie Abrivard, Christine Katlama, Yazdan Yazdanpanah, Gilles Pialoux, Pierre-Marie Girard, Dominique Costagliola
Background: Silent cerebral small-vessel disease (CSVD) is defined as white matter hyperintensities, silent brain infarction or microbleeds. CSVD is responsible for future vascular events, cognitive impairment, frailty and shorter survival. CSVD prevalence among middle-aged persons living with well-controlled HIV infection (PLHIVs) is unknown. Methods: ANRS EP51 MicroBREAK (NCT02082574) is a cross-sectional study with prospective enrollment of treated PLHIVs, ≥50 years old with viral load controlled for ≥12 months, and frequency age- and sex-matched HIV-uninfected controls (HUCs)...
December 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29244104/-if-it-s-issues-to-do-with-nutrition%C3%A2-i-can-decide%C3%A2-gendered-decision-making-in-joining-community-based-child-nutrition-interventions-within-rural-coastal-kenya
#7
Kelly W Muraya, Caroline Jones, James A Berkley, Sassy Molyneux
Gender roles and relations play an important role in child health and nutritional status. While there is increasing recognition of the need to incorporate gender analysis in health planning and programme development, there has been relatively little attention paid to the gendered nature of child nutrition interventions. This qualitative study undertaken in rural Coastal Kenya aimed to explore the interaction between household gender relations and a community-based child nutrition programme, with a focus on household decision-making dynamics related to joining the intervention...
December 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29244069/impact-of-comprehensive-minimally-invasive-multimodal-aesthetic-treatment-on-satisfaction-with-facial-appearance-the-harmony-study
#8
Susan H Weinkle, W Philip Werschler, Craig F Teller, Jonathan M Sykes, Ava Shamban, Alexander Rivkin, Vic A Narurkar, Michael S Kaminer, Steven Dayan, Joel L Cohen, Conor J Gallagher
Background: Individuals seeking aesthetic treatment have concerns regarding multiple facial areas. Objectives: Assess the aesthetic impact and satisfaction achieved with a multimodal approach to aesthetic treatment using a combination of minimally invasive treatments. Methods: Prospective, multicenter, rater-blinded, 4-month HARMONY study evaluated patient satisfaction and aesthetic impact of a combination of fillers (VYC-20L, HYC-24L, and HYC-24L+), onabotulinumtoxinA, and bimatoprost...
December 13, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29244026/jnj-63623872-treatment-in-adult-volunteers-experimentally-inoculated-with-live-influenza-virus-a-phase-iia-randomized-double-blind-placebo-controlled-study
#9
Jose M Trevejo, Mohammed Asmal, Johan Vingerhoets, Ramon Polo, Sarah Robertson, Ying Jiang, Tara L Kieffer, Lorant Leopold
BACKGROUND: JNJ-63623872 is a novel, non-nucleoside polymerase complex inhibitor with in vitro activity against influenza A virus, including pandemic 2009 H1N1, H7N9, H5N1 strains as well as neuraminidase-and amantadine-resistant strains. METHODS: Randomized, double-blind, placebo-controlled, Phase 2a study. Healthy volunteers (N = 104) were inoculated with an influenza A/Wisconsin/67/2005 (H3N2) challenge virus. 72 received JNJ-63623872 and 32 placebo. JNJ-63623872 was dosed for 5 days once daily from 24 hours after viral inoculation at four dose levels: 100 mg, 400 mg, loading dose 900/600 mg and loading dose 1200/600 mg...
December 15, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/29243739/frozen-sections-are-unreliable-for-the-diagnosis-of-necrotizing-soft-tissue-infections
#10
Isaac H Solomon, Rene Borscheid, Alvaro C Laga, Reza Askari, Scott R Granter
Necrotizing soft tissue infections are rare but are associated with high rates of morbidity and mortality. The use of bedside or intraoperative frozen sections has been reported to be associated with faster diagnosis and better outcomes; however, to date no large studies have been published to determine the sensitivity and specificity of frozen sections in this setting. Twenty years of cases suspicious for necrotizing soft tissue infection at a large academic referral center were reviewed, blinded to the final clinical diagnosis (gold standard)...
December 15, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29243736/a-novel-missense-mutation-in-hsf4-causes-autosomal-dominant-congenital-lamellar-cataract-in-a-british-family
#11
V Berry, N Pontikos, A Moore, A C W Ionides, V Plagnol, M E Cheetham, M Michaelides
PurposeInherited cataract, opacification of the lens, is the most common worldwide cause of blindness in children. We aimed to identify the genetic cause of isolated autosomal-dominant lamellar cataract in a five-generation British family.MethodsWhole exome sequencing (WES) was performed on two affected individuals of the family and further validated by direct sequencing in family members.ResultsA novel missense mutation NM_001040667.2:c.190A>G;p.K64E was identified in the DNA-binding-domain of heat-shock transcription factor 4 (HSF4) and found to co-segregate with disease...
December 15, 2017: Eye
https://www.readbyqxmd.com/read/29243532/use-of-transcranial-direct-stimulation-in-the-treatment-of-negative-symptoms-of-schizophrenia
#12
Maria Pontillo, Floriana Costanzo, Deny Menghini, Roberto Averna, Ornella Santonastaso, Maria Cristina Tata, Stefano Vicari
Schizophrenia is a debilitating disease that affects approximately 1% of the population. Negative symptoms are among the major determinants of the functional impairment and a significant proportion of patients with negative symptoms will continue to experience these symptoms despite antipsychotic medications. There are promising results in the application of brain stimulation, particularly transcranial direct current stimulation (tDCS), for the reduction of negative symptoms of schizophrenia. However, findings are still controversial...
January 2018: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/29243483/relative-binding-free-energy-calculations-in-drug-discovery-recent-advances-and-practical-considerations
#13
Zoe Cournia, Bryce Allen, Woody Sherman
Accurate in silico prediction of protein-ligand binding affinities has been a primary objective of structure-based drug design for decades due to the putative value it would bring to the drug discovery process. However, computational methods have historically failed to deliver value in real-world drug discovery applications due to a variety of scientific, technical, and practical challenges. Recently, a family of approaches commonly referred to as relative binding free energy (RBFE) calculations, which rely on physics-based molecular simulations and statistical mechanics, have shown promise in reliably generating accurate predictions in the context of drug discovery projects...
December 15, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29243450/pathogenesis-of-age-related-macular-degeneration-dialogue-between-autophagy-and-inflammasomes
#14
Niko Kivinen, Ali Koskela, Anu Kauppinen, Kai Kaarniranta
Age-related macular degeneration is a condition affecting central vision, and is the leading cause of blindness and visual impairment in the western countries. For a long time, inflammation has been associated with the pathogenesis of the condition, and according to current knowledge, inflammation in the retinal pigment epithelial cells (RPE) results from an impairment of intracellular cleansing systems. In combination with the degeneration of RPE cells, this eventually leads to the destruction of light-sensing cells...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29243441/-efficacy-and-safety-of-kuhuang-injection-in-treating-viral-hepatitis%C3%AF-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#15
Jun Zhao, Xing Liao, Hui Zhao, Jing Yang, Wen Zou, Le Wang, Ying-Jie Zhi
To systematically evaluate the effectiveness and safety of Kuhuang injection in treating viral hepatitis. Eight electronic databases and clinic trials were searched to collect randomized controlled trials for the effect of Kuhuang injection in the treatment of viral hepatitis. According to the Cochrane Handbook 5.1, two independent reviewers screened out the literatures, extracted data and assessed the quality of thestudies included. RevMan5.3 software was used for the data analysis. A total of 32 articles were included, involving 3 188 patients, including male 1 951 cases (61...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29243411/randomized-crossover-trial-comparing-eus-guided-fine-needle-aspiration-with-eus-guided-fine-needle-biopsy-for-gastric-subepithelial-tumors
#16
Tomohisa Iwai, Mitsuhiro Kida, Hiroshi Imaizumi, Shiro Miyazawa, Kosuke Okuwaki, Hiroshi Yamauchi, Toru Kaneko, Rikiya Hasegawa, Eiji Miyata, Wasaburo Koizumi
AIM: The purpose of this study is to compare the diagnostic yield of endoscopic ultrasound (EUS)-guided fine-needle aspiration (EUS-FNA) and EUS-guided fine-needle biopsy (EUS-FNB) for gastric subepithelial tumors (SET). METHODS: Patients diagnosed SET derived from fourth layer of the stomach were prospectively enrolled and randomly assigned to undergo both EUS-FNA using standard needle and EUS-FNB using a core biopsy needle alternatively to the same lesion a total of four times per session...
December 15, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29243111/retrospective-comparison-of-measured-stone-size-and-posterior-acoustic-shadow-width-in-clinical-ultrasound-images
#17
Jessica C Dai, Barbrina Dunmire, Kevan M Sternberg, Ziyue Liu, Troy Larson, Jeff Thiel, Helena C Chang, Jonathan D Harper, Michael R Bailey, Mathew D Sorensen
PURPOSE: Posterior acoustic shadow width has been proposed as a more accurate measure of kidney stone size compared to direct measurement of stone width on ultrasound (US). Published data in humans to date have been based on a research using US system. Herein, we compared these two measurements in clinical US images. METHODS: Thirty patient image sets where computed tomography (CT) and US images were captured less than 1 day apart were retrospectively reviewed. Five blinded reviewers independently assessed the largest stone in each image set for shadow presence and size...
December 14, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29243086/utility-of-pulse-oximetry-to-detect-aspiration-an-evidence-based-systematic-review
#18
REVIEW
Deanna Britton, Amy Roeske, Stephanie K Ennis, Joshua O Benditt, Cassie Quinn, Donna Graville
Pulse oximetry is a commonly used means to measure peripheral capillary oxyhemoglobin saturation (SpO2). Potential use of pulse oximetry to detect aspiration is attractive to clinicians, as it is readily available, quick, and noninvasive. However, research regarding validity has been mixed. This systematic review examining evidence on the use of pulse oximetry to detect a decrease in SpO2 indicating aspiration during swallowing is undertaken to further inform clinical practice in dysphagia assessment. A multi-engine electronic search was conducted on 8/25/16 and updated on 4/8/17 in accordance with standards published by the Preferred Reporting for Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA)...
December 14, 2017: Dysphagia
https://www.readbyqxmd.com/read/29242937/paclitaxel-with-and-without-pazopanib-for-persistent-or-recurrent-ovarian-cancer-a-randomized-clinical-trial
#19
Debra L Richardson, Michael W Sill, Robert L Coleman, Anil K Sood, Michael L Pearl, Siobhan M Kehoe, Michael E Carney, Parviz Hanjani, Linda Van Le, Xun C Zhou, Angeles Alvarez Secord, Heidi J Gray, Lisa M Landrum, Heather A Lankes, Wei Hu, Carol Aghajanian
Importance: Ovarian cancer is the leading cause of gynecologic cancer deaths in the United States. Pazopanib is an oral, multitarget kinase inhibitor of vascular endothelial growth factor receptors 1, 2, and 3; platelet-derived growth factor receptors α and β; and proto-oncogene receptor tyrosine kinase (c-KIT). Objective: To estimate the progression-free survival (PFS) hazard ratio (HR) of weekly paclitaxel and pazopanib compared with weekly paclitaxel and placebo in women with recurrent ovarian cancer...
December 14, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29242928/association-of-sex-with-the-global-burden-of-cataract
#20
Lixia Lou, Xin Ye, Peifang Xu, Jingyi Wang, Yufeng Xu, Kai Jin, Juan Ye
Importance: Eye disease burden could help guide health policy making. Differences in cataract burden by sex is a major concern of reducing avoidable blindness caused by cataract. Objective: To investigate the association of sex with the global burden of cataract by year, age, and socioeconomic status using disability-adjusted life-years (DALYs). Design, Setting, and Participants: This international, comparative burden-of-disease study extracted the global, regional, and national sex-specific DALY numbers, crude DALY rates, and age-standardized DALY rates caused by cataract by year and age from the Global Burden of Disease Study 2015...
December 14, 2017: JAMA Ophthalmology
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