keyword
MENU ▼
Read by QxMD icon Read
search

Blindness

keyword
https://www.readbyqxmd.com/read/29908472/cognitive-bias-modification-as-an-add-on-treatment-in-clinical-depression-results-from-a-placebo-controlled-single-blinded-randomized-control-trial
#1
Janna N Vrijsen, Verena S Fischer, Bernhard W Müller, Norbert Scherbaum, Eni S Becker, Mike Rinck, Indira Tendolkar
BACKGROUND: Only 60% of depressed patients respond sufficiently to treatment, so there is a dire need for novel approaches to improve treatment effects. Cognitive Bias Modification (CBM) may be an effective and easily implemented computerized add-on to treatment-as-usual. Therefore, we investigated the effects of a positivity-attention training and a positivity-approach training compared to control trainings. METHODS: In a blinded randomized-controlled design, 139 depressed inpatients received either the CBM Attention Dot-Probe Training (DPT) or the CBM Approach-Avoidance Training (AAT), next to treatment as usual...
June 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29908435/brivaracetam-induced-elevation-of-carbamazepine-epoxide-levels-a-post-hoc-analysis-from-the-clinical-development-program
#2
Martin J Brodie, Toufic Fakhoury, Belinda McDonough, Anny-Odile Colson, Armel Stockis, Sami Elmoufti, John Whitesides
To assess the association, if any, between brivaracetam (BRV)-induced elevated carbamazepine-10,11-epoxide (CBZ-E) and toxicity and efficacy in patients with epilepsy. Data were pooled from three double-blind, placebo-controlled, Phase III studies of adjunctive BRV in adults with uncontrolled focal seizures (N01252/NCT00490035, N01253/NCT00464269, N01358/NCT01261325). Treatment-emergent adverse events (TEAEs) of interest (ataxia, diplopia, dizziness, nystagmus, somnolence, accidental overdose or poisoning, and toxicity), discontinuations due to TEAEs, and serious TEAEs (SAEs) were assessed in subgroups who did/did not receive carbamazepine (CBZ) at study entry (CBZ+ and CBZ-)...
June 4, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29908420/ticagrelor-versus-clopidogrel-after-fibrinolytic-therapy-in-patients-with-st-elevation-myocardial-infarction-rationale-and-design-of-the-ticagrelor-in-patients-with-st-elevation-myocardial-infarction-treated-with-thrombolysis-treat-trial
#3
Otavio Berwanger, Jose C Nicolau, Antonio C Carvalho, Lixin Jiang, Shaun Goodman, Stephen J Nicholls, Alexander Parkhomenko, Oleg Averkov, Carlos Tajer, Germán Malaga, Jose F Kerr Saraiva, Francisco Fonseca, Helio P Guimaraes, Pedro G M de Barros E Silva, Lucas P Damiani, Denise M Paisani, Camila M R Lasagno, Carolina T Candido, Nanci Valeis, Diogo D F Moia, Leopoldo S Piegas, Christopher B Granger, Harvey White, Renato D Lopes
BACKGROUND: The safety and efficacy of ticagrelor in patients with ST-elevation myocardial infarction (STEMI) treated with fibrinolytic therapy remain uncertain. OBJECTIVES: The primary objective of the TicagRElor in pAtients with ST elevation myocardial infarction treated with Thrombolysis (TREAT) trial is to evaluate the short-term safety of ticagrelor when compared with clopidogrel in STEMI patients treated with fibrinolytic therapy. Key secondary objectives are to assess the safety and efficacy of ticagrelor compared with clopidogrel at 12-months...
March 3, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29908405/objective-predictors-of-early-tolerance-to-ventral-intermediate-nucleus-of-thalamus-deep-brain-stimulation-in-essential-tremor-patients
#4
Shabbir Hussain Merchant, Sheng-Han Kuo, Yu Qiping, Linda Winfield, Guy McKhann, Sameer Sheth, Seth L Pullman, Blair Ford
OBJECTIVE: To identify pre-operative clinical and computerized spiral analysis characteristics that may help ascertain which patients with Essential Tremor (ET) will exhibit 'early tolerance' to ventral intermediate nucleus of thalamus (Vim) deep brain stimulation (DBS). METHODS: Identification of comparative characteristics of defined cases of 'early tolerance' versus patients with sustained satisfactory response treated with Vim DBS surgery for medically-refractory ET, based on retrospective chart review by a clinician blinded to the findings of computerized spiral analysis...
June 5, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29908359/statin-therapy-does-not-reduce-liver-fat-scores-in-patients-receiving-antiretroviral-therapy-for-hiv-infection
#5
Vanessa El Kamari, Corrilynn O Hileman, Pierre M Gholam, Manjusha Kulkarni, Nicholas Funderburg, Grace A McComsey
BACKGROUND & AIMS: Therapies are needed to limit progression of fatty liver diseases in patients with HIV infection. We analyzed data from a prospective study of the effects of rosuvastatin (a statin) on hepatic steatosis in HIV-positive adults. METHODS: We performed secondary analysis of data from a double-blind trial of adult patients with HIV infection (78% male; 68% African American; mean age, 46 years; body mass index, 29 kg/m2 ; HIV1 RNA<1000 copies/mL; LDL-cholesterol <130 mg/dL) receiving antiretroviral therapy...
June 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29908297/prevention-of-breast-cancer-treatment-induced-bone-loss-in-premenopausal-women-treated-with-zoledronic-acid-final-5-year-results-from-the-randomized-double-blind-placebo-controlled-probone-ii-trial
#6
Ioannis Kyvernitakis, Peter Herbert Kann, Friederike Thomasius, Olaf Hars, Peyman Hadji
PURPOSE: Premenopausal women receiving chemotherapy or endocrine treatment for early breast cancer are at increased risk for cancer treatment induced bone loss (CTIBL). The aim of the randomized, double-blind ProBONE II trial was to investigate whether a 2-year adjuvant treatment with 4 mg intravenous zoledronic acid (ZOL) every 3 months versus placebo would prevent CTIBL after a five-year period. METHODS: Thirty-one of the 34 participants in the ZOL arm and thirty-four of the 36 participants in the placebo arm were followed-up to the 5-year visit and completed the study as planned...
June 13, 2018: Bone
https://www.readbyqxmd.com/read/29908281/ltbp2-knockdown-and-oxidative-stress-affect-glaucoma-features-including-tgf%C3%AE-pathways-ecm-genes-expression-and-apoptosis-in-trabecular-meshwork-cells
#7
Fatemeh Suri, Shahin Yazdani, Elahe Elahi
Glaucoma is the leading cause of irreversible blindness worldwide. Although the etiology of glaucoma is incompletely understood, it is known that the extracellular matrix (ECM) of the trabecular meshwork, oxidative stress, TGFβ signaling pathways, and apoptosis are important components of glaucoma pathogenesis. These components appear to be interrelated, but knowledge on their interactions remains incomplete. Relevant to this gap in knowledge, LTBP2, glaucoma causing gene, may also be related to the mentioned components of glaucoma pathogenesis because of its putative roles in TGFβ signaling and ECM functions...
June 13, 2018: Gene
https://www.readbyqxmd.com/read/29908178/new-generation-full-spectrum-endoscopy-versus-standard-forward-viewing-colonoscopy-a-multicenter-randomized-tandem-colonoscopy-trial-j-fuse-study
#8
Toyoki Kudo, Yutaka Saito, Hiroaki Ikematsu, Kinichi Hotta, Yoji Takeuchi, Masaaki Shimatani, Ken Kawakami, Naoto Tamai, Yuichi Mori, Yasuharu Maeda, Masayoshi Yamada, Taku Sakamoto, Takahisa Matsuda, Kenichiro Imai, Sayo Ito, Kenta Hamada, Norimasa Fukata, Takuya Inoue, Hisao Tajiri, Kenichi Yoshimura, Hideki Ishikawa, Shin-Ei Kudo
OBJECTIVES: Although colonoscopy is the criterion standard for detection of colorectal adenomas, some adenomas are missed. Full-spectrum endoscopy (FUSE) allows for observation with a 330° angle of view, which is expected to decrease the miss rate. However, no consensus has been reached regarding the superiority of FUSE over standard forward-viewing colonoscopy (SFVC) for detection of adenomas; we therefore compared new-generation FUSE and SFVC regarding colorectal adenoma miss rate (AMR) in this, the first reported randomized control trial using new-generation FUSE...
June 13, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29908078/ultrasound-detection-of-insulin-induced-lipohypertrophy-in-type-1-and-type-2-diabetes
#9
J E Kapeluto, B W Paty, S D Chang, G S Meneilly
AIMS: To define standard criteria for the detection of lipohypertrophy using ultrasonography and to determine the accuracy of this method. METHOD: Individuals using insulin therapy for ≥2 years with unknown lipohypertrophy status were enrolled at a diabetes education centre. A team of diabetes educator nurses performed a clinical examination for evidence of lipohypertrophy and a separate team of ultrasonographers examined participants in a blinded fashion. RESULTS: The echo signature for lipohypertrophy consisted of location in the subcutaneous layer and lesions that were 1) well circumscribed either by hyperechoic foci with defined borders or a nodular shape with a hypoechoic halo, 2) heterogeneous in echotexture compared with surrounding tissue, 3) associated with distortion of surrounding connective tissue with 4) absence of vascularity and 5) absence of capsule...
June 16, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29908043/a-first-in-human-study-of-the-safety-tolerability-pharmacokinetics-and-pharmacodynamics-of-pf-06741086-an-anti-tfpi-monoclonal-antibody-in-healthy-volunteers
#10
Matthew Cardinal, Constantino Kantaridis, Tong Zhu, Pengling Sun, Debra D Pittman, John E Murphy, Steven Arkin
BACKGROUND: Tissue factor pathway inhibitor (TFPI) is a protease inhibitor of tissue factor-activated coagulation factor VII (TF-FVIIa) complex and activated factor X (FXa). PF-06741086 is a monoclonal antibody that targets TFPI to increase clotting activity. OBJECTIVES: This study was a randomized, double-blind, sponsor-open, placebo-controlled, single intravenous (IV) or subcutaneous (SC) dose escalation study to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of PF-06741086...
June 16, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29908039/no-neurodevelopmental-benefit-of-cerebral-oximetry-in-the-first-randomised-trial-in-preterm-infants-during-the-first-days-of-life-safeboosc-ii
#11
Anne M Plomgaard, Thomas Alderliesten, Frank van Bel, Manon Benders, Olivier Claris, Malaika Cordeiro, Eugene Dempsey, Monica Fumagalli, Christian Gluud, Simon Hyttel-Sorensen, Petra Lemmers, Adelina Pellicer, Gerhard Pichler, Gorm Greisen
AIM: Cerebral hypoxia has been associated with neurodevelopmental impairment. We studied whether reducing cerebral hypoxia in extremely preterm infants during the first 72 hours of life affected neurological outcomes at two years of corrected age. METHODS: In 2012-2013 the phase II randomised Safeguarding the Brains of our Smallest Children trial compared visible cerebral near infrared spectroscopy (NIRS) monitoring in an intervention group and blinded NIRS monitoring in a control group...
June 16, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29908038/the-effect-of-dietary-corn-oil-and-fish-oil-supplementation-in-dogs-with-naturally-occurring-gingivitis
#12
Ana L Lourenço, Henriette E Booij-Vrieling, Carmen B Vossebeld, António Neves, Carlos Viegas, Ronald J Corbee
The aim of this randomized, double-blinded, placebo-controlled study was to evaluate if downregulation of the inflammatory response due to ingestion of high levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can slow down gingivitis development, and thus delay the progression of periodontal disease (PD) in dogs. To this aim, 44 client-owned adult dogs (>1 and <8 years old) with naturally occurring PD (stages 1 and 2) were submitted to a plaque, gingivitis and calculus scoring followed by a dental cleaning procedure and collection of blood samples...
June 16, 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29907752/acceptability-of-placebo-multiparticulate-formulations-in-children-and-adults
#13
Felipe L Lopez, Punam Mistry, Hannah K Batchelor, Joanne Bennett, Alastair Coupe, Terry B Ernest, Mine Orlu, Catherine Tuleu
Patient acceptability is an important consideration in the design of medicines for children. The aim of this study was to investigate acceptability of multiparticulates in healthy children and adults. A randomised, single-blind acceptability testing was performed involving 71 children (4-12 years) and 61 adults (18-37 years). Each participant received three 500 mg samples of microcrystalline cellulose pellets administered on a medicine spoon with water at 5-10 minutes intervals. Acceptability was measured based on voluntary intake of the samples, facial expressions, ratings on hedonic scales and reported willingness to take multiparticulates everyday as a medicine...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907634/strengthening-the-links-between-mapping-planning-and-global-engagement-for-disease-elimination-lessons-learnt-from-trachoma
#14
Paul Courtright, Lisa A Rotondo, Chad MacArthur, Iain Jones, Angela Weaver, Biruck Kebede Negash, Nicholas Olobio, Kamal Binnawi, Simon Bush, Mariamo Abdala, Danny Haddad, Astrid Bonfield, Paul Emerson, Virginia Sarah, Anthony W Solomon
BACKGROUND: Trachoma is the leading infectious cause of blindness. Until recently, reliable data on the global extent of the disease, detailed plans for elimination, and government, donor and partner engagement were all inadequate. METHODS: The trachoma community undertook a systematic, three-pronged strategy to map trachoma district by district, develop national-level trachoma elimination plans, and create a framework for governments, donors and partners to convene and coordinate in support of trachoma elimination...
June 15, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29907608/noninvasive-vagus-nerve-stimulation-as-acute-therapy-for-migraine-the-randomized-presto-study
#15
Cristina Tassorelli, Licia Grazzi, Marina de Tommaso, Giulia Pierangeli, Paolo Martelletti, Innocenzo Rainero, Stefanie Dorlas, Pierangelo Geppetti, Anna Ambrosini, Paola Sarchielli, Eric Liebler, Piero Barbanti
OBJECTIVE: To evaluate the efficacy, safety, and tolerability of noninvasive vagus nerve stimulation (nVNS; gammaCore; electroCore, LLC, Basking Ridge, NJ) for the acute treatment of migraine in a multicenter, double-blind, randomized, sham-controlled trial. METHODS: A total of 248 participants with episodic migraine with/without aura were randomized to receive nVNS or sham within 20 minutes from pain onset. Participants were to repeat treatment if pain had not improved in 15 minutes...
June 15, 2018: Neurology
https://www.readbyqxmd.com/read/29907533/perinatal-care-needs-and-expectations-of-women-with-low-vision-or-total-blindness-in-warsaw-poland
#16
Barbara Mazurkiewicz, Małgorzata Stefaniak, Ewa Dmoch-Gajzlerska
BACKGROUND: As estimated from the number of published studies, in Poland the research into the perinatal care experiences of women with low vision or total blindness remains limited. OBJECTIVES: The purpose of the study was to fill this gap by investigating satisfaction with perinatal care received by women with visual impairment in four city hospitals in Warsaw, Poland, and to recommend, if required, modifications in midwives' education and care standards based on the women's perceptions and expectations...
June 12, 2018: Disability and Health Journal
https://www.readbyqxmd.com/read/29907419/comparison-of-breast-density-between-synthesized-versus-standard-digital-mammography
#17
Irfanullah Haider, Matthew Morgan, Anna McGow, Matthew Stein, Maryam Rezvani, Phoebe Freer, Nan Hu, Laurie Fajardo, Nicole Winkler
PURPOSE: To evaluate perceptual difference in breast density classification using synthesized mammography (SM) compared with standard or full-field digital mammography (FFDM) for screening. MATERIALS AND METHODS: This institutional review board-approved, retrospective, multireader study evaluated breast density on 200 patients who underwent baseline screening mammogram during which both SM and FFDM were obtained contemporaneously from June 1, 2016, through November 30, 2016...
June 12, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29907395/comparison-of-clinical-risk-scores-for-triaging-high-risk-chest-pain-patients-at-the-emergency-department
#18
Salah S Al-Zaiti, Ziad Faramand, Mohammad O Alrawashdeh, Susan M Sereika, Christian Martin-Gill, Clifton Callaway
BACKGROUND: Many of the clinical risk scores routinely used for chest pain assessment have not been validated in patients at high risk for acute coronary syndrome (ACS). We performed an independent comparison of HEART, TIMI, GRACE, FRISC, and PURSUIT scores for identifying chest pain due to ACS and for predicting 30-day death or re-infarction in patients arriving through Emergency Medical Services (EMS). METHODS AND RESULTS: We enrolled consecutive EMS patients evaluated for chest pain at three emergency departments...
June 8, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29907335/trial-protocol-the-use-of-mindfulness-based-intervention-for-improving-bracing-compliance-for-adolescent-idiopathic-scoliosis-patients-protocol-for-a-randomised-controlled-trial
#19
Benjamin Hon Kei Yip, Xue Li, Christine Hiu Yan Leung, Ting Gao, Vincent Chi Ho Chung, Fiona Wai Ping Yu, Tsz Ping Lam, Jack Chun Yiu Cheng, Samuel Yeung Shan Wong
INTRODUCTION: Adolescent idiopathic scoliosis (AIS) is the most prevalent deforming orthopaedic condition; it causes significant disability when spinal curves progress beyond 45deg. Bracing is the primary treatment prescribed for adolescents with an immature skeleton who have spinal curves between 25 and 45deg. New evidence suggests that compliance with bracing significantly decreases the progression of high-risk curves to the threshold for surgery. Nonetheless, bracing is a stressful experience...
June 12, 2018: Journal of Physiotherapy
https://www.readbyqxmd.com/read/29907165/management-of-ocular-human-herpesvirus-1-infection-in-a-white%C3%A2-faced-saki-monkey-pithecia-pithecia
#20
Kendra L Bauer, James C Steeil, Elizabeth A Adkins, April L Childress, James F X Wellehan, Kenton L Kerns, Steven J Sarro, Kali A Holder
A 20-y-old male intact white-faced saki monkey (Pithecia pithecia) presented with an acute ocular disease of the righteye.Clinical signs included periocular swelling, conjunctivitis, and anisocoria with a miotic right pupil. Conjunctival swabs werepositive for Human herpesvirus 1 (HHV1) according to PCR amplification with sequencing. Initial clinical signs resolvedwith supportive treatment, and the animal was managed chronically by using acyclovir (5 mg/kg PO twice daily) during flare-ups. After more than 2 y, the progression of clinical disease led to enucleation of the right eye...
June 15, 2018: Comparative Medicine
keyword
keyword
24554
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"