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Trigeminal nerve

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https://www.readbyqxmd.com/read/29664111/morphological-and-functional-changes-in-trpm8-expressing-corneal-cold-thermoreceptor-neurons-during-aging-and-their-impact-on-tearing-in-mice
#1
Ignacio Alcalde, Almudena Íñigo-Portugués, Omar González-González, Laura Almaraz, Enol Artime, Cruz Morenilla-Palao, Juana Gallar, Félix Viana, Jesús Merayo-Lloves, Carlos Belmonte
Morphological and functional alterations of peripheral somatosensory neurons during the aging process lead to a decline of somatosensory perception. Here, we analyze the changes occurring with aging in trigeminal ganglion (TG), TRPM8-expressing cold thermoreceptor neurons innervating the mouse cornea, which participate in the regulation of basal tearing and blinking and have been implicated in the pathogenesis of dry eye disease (DED). TG cell bodies and axonal branches were examined in a mouse line (TRPM8BAC -EYFP) expressing a fluorescent reporter...
April 17, 2018: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29661478/chronic-adriamycin-treatment-impairs-cgrp-mediated-functions-of-meningeal-sensory-nerves
#2
Éva Deák, Judit Rosta, Krisztina Boros, Gyöngyi Kis, Péter Sántha, Karl Messlinger, Gábor Jancsó, Mária Dux
Adriamycin is a potent anthracycline-type antitumor agent, but it also exerts potentially serious side effects due to its cardiotoxic and neurotoxic propensity. Multiple impairments in sensory nerve functions have been recently reported in various rat models. The present experiments were initiated in an attempt to reveal adriamycin-induced changes in sensory effector functions of chemosensitive meningeal afferents. Meningeal blood flow was measured with laser Doppler flowmetry in the parietal dura mater of adult male Wistar rats...
April 10, 2018: Neuropeptides
https://www.readbyqxmd.com/read/29660047/trigeminal-nerve-atrophy-predicts-pain-recurrence-after-gamma-knife-stereotactic-radiosurgery-for-classical-trigeminal-neuralgia
#3
Yong-Sin Hu, Cheng-Chia Lee, Wan-Yuo Guo, Chung-Jung Lin, Huai-Che Yang, Hsiu-Mei Wu, Kang-Du Liu, Wen-Yuh Chung
BACKGROUND: Trigeminal nerve atrophy and neurovascular compression (NVC) are frequently observed in classical trigeminal neuralgia (CTN). OBJECTIVE: To determine whether nerve characteristics contribute to Gamma Knife (Elekta AB, Stockholm, Sweden) surgery (GKS) outcomes in unilateral CTN without previous surgery. METHODS: From 2006 to 2012, 67 patients with unilateral CTN without previous surgery received GKS with a maximal dose of 90 Gy delivered to the trigeminal nerve juxta brainstem...
April 11, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29659161/neurovascular-relations-of-the-trigeminal-nerve-in-asymptomatic-individuals-studied-with-high-resolution-three-dimensional-magnetic-resonance-imaging
#4
Fernando Ruiz-Juretschke, Laín H González-Quarante, Roberto García-Leal, Vicente Martínez de Vega
Neurovascular compression (NVC) is considered the main cause of classic trigeminal neuralgia (TN) and may be surgically addressed with microvascular decompression (MVD). Preoperative high-resolution three-dimensional magnetic resonance has proven a reliable tool to diagnose NVC in patients with refractory TN undergoing MVD. However there is still scarce data regarding the rate, degree and characteristics of neurovascular compression in asymptomatic individuals. This article describes the vascular relations of the trigeminal nerve in the cerebellopontine angle (CPA) in 100 subjects without known TN studied with 3...
April 16, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29657082/horner-s-syndrome-following-obstetric-neuraxial-blockade-a-systematic-review-of-the-literature
#5
D J Chambers, K Bhatia
Horner's syndrome is a rarely reported complication of neuraxial blockade. In obstetric practice, the neurological signs of Horner's syndrome may cause anxiety amongst patients and healthcare staff, but more importantly may herald the onset of maternal hypotension. Medline, CINAHL, and EMBASE databases were searched to identify cases of Horner's syndrome following obstetric neuraxial blockade. Anaesthetic technique, clinical features, anaesthetic management of the Horner's syndrome and time to resolution were assessed...
March 17, 2018: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/29649644/endoscopic-transseptal-approach-with-a-bilateral-nasoseptal-flap-in-challenging-skull-base-tumors
#6
Do Hyun Kim, Yong-Kil Hong, Sin-Soo Jeun, Jae-Sung Park, Soo Whan Kim, Jin Hee Cho, Yong Jin Park, Sung Won Kim
OBJECTIVE: To examine the utility of an endoscopic transseptal approach and the creation of a bilateral nasoseptal flap using a two-nostrils/four-hands technique in patients with challenging skull-base tumors. METHODS: The medical records of patients operated on via an endoscopic transseptal approach between 2009 and 2017 were retrospectively reviewed. Two patients with ossifying fibroma, two with orbital hemangioma, two with trigeminal nerve schwannoma, and one patient each with juvenile angiofibroma, meningioma, and myxofibrosarcoma were included in the study...
April 9, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29629601/occipital-neuralgia-associates-with-high-cervical-spinal-cord-lesions-in-idiopathic-inflammatory-demyelinating-disease
#7
Narayan R Kissoon, James C Watson, Christopher J Boes, Orhun H Kantarci
Background The association of trigeminal neuralgia with pontine lesions has been well documented in multiple sclerosis, and we tested the hypothesis that occipital neuralgia in multiple sclerosis is associated with high cervical spinal cord lesions. Methods We retrospectively reviewed the records of 29 patients diagnosed with both occipital neuralgia and demyelinating disease by a neurologist from January 2001 to December 2014. We collected data on demographics, clinical findings, presence of C2-3 demyelinating lesions, and treatment responses...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29626689/petrous-face-meningiomas-classification-clinical-syndromes-and-surgical-outcomes
#8
Stephen T Magill, Jonathan W Rick, William C Chen, David A Haase, David R Raleigh, Manish K Aghi, Philip V Theodosopoulos, Michael W McDermott
BACKGROUND: Petrous face meningiomas (PFM) are challenging tumors due to their proximity to the cranial nerves, brainstem and critical vasculature. The objective of this study is to present surgical outcomes and support an anatomic classification for PFM based on clinical presentation. METHODS: A retrospective chart review was performed, and 51 PFM were identified. Tumors were classified by location along the petrous face into anterior, middle and posterior. Presentation and outcomes were analyzed with logistic regression...
April 4, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29626679/gamma-knife-radiosurgery-for-trigeminal-neuralgia-associated-with-osteogenesis-imperfecta
#9
Yoshiyasu Iwai, Kenichi Ishibashi, Kazuhiro Yamanaka
OBJECTIVE: Trigeminal neuralgia is a rare feature of basilar impression, a complication of osteochondrodysplastic disorders. Microvascular decompression is difficult in medically refractory cases. Gamma knife radiosurgery (GKS) is effective for classical trigeminal neuralgia and we first applied this GKS for a patient suffering from trigeminal neuralgia with basilar impression complicated by osteogenesis imperfecta. CLINICAL PRESENTATION: An 18-year-old man with typeⅠosteogenesis imperfecta presented with a 2-year history of typical left trigeminal neuralgia affecting the ophthalmic, maxillary, and mandibular nerves...
April 4, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29625453/substance-p-modulation-of-human-and-murine-corneal-neovascularization
#10
Marco Barbariga, Phillippe Fonteyne, Manoosh Ostadreza, Fabio Bignami, Paolo Rama, Giulio Ferrari
Purpose: The purpose of this study was to investigate the role of substance P (SP) in patients affected with corneal neovascularization (CNV) and in three different Tac1-knockout (KO) murine models of CNV. Methods: SP levels in tears were measured with a multiplex bead assay. The extent of human CNV was quantified as number of affected corneal quadrants. Murine CNV was induced in both strains by means of total disepithelization, alkali burn, and intrastromal sutures...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29624148/reliability-of-mri-for-predicting-characteristics-of-neurovascular-conflicts-in-trigeminal-neuralgia-implications-for-surgical-decision-making
#11
Andrei Brînzeu, Landry Drogba, Marc Sindou
OBJECTIVE The choice of microvascular decompression (MVD), among the several other surgical options, for treating refractory classical trigeminal neuralgia (TN) relies mostly on preoperative imaging, but the degree of reliability of MRI remains a matter of debate. The authors approached the question of predictability of neurovascular conflict (NVC) in a series of 100 protocolized MRI studies from patients with TN who underwent MVD, by reexamination of MR images, blinded to the clinical data and surgical findings, including the side of the neuralgia...
April 6, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29623520/cgrp-monoclonal-antibodies-for-the-preventative-treatment-of-migraine
#12
REVIEW
Heike Israel, Lars Neeb, Uwe Reuter
PURPOSE OF REVIEW: CGRP is a key neuropeptide in migraine pathophysiology. The blockade of the CGRP pathway at the side of the CGRP receptor of the CGRP peptide leads to the interruption of trigeminal nerve system-mediated headache syndromes such as migraine. Monoclonal antibodies (mAbs) targeting the CGRP pathway have been developed and are currently under investigation for episodic (EM) and chronic migraine (CM) prevention. Here, we report data from these clinical trials. RECENT FINDINGS: Placebo-controlled, randomized double-blind phase studies of CGRP mAbs in episodic and chronic migraine have shown that the specific blockade of the peptide or the CGRP receptor are both powerful mechanisms to reduce migraine frequency...
April 6, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29615872/projections-of-the-diencephalospinal-dopaminergic-system-to-peripheral-sense-organs-in-larval-zebrafish-danio-rerio
#13
Melanie Haehnel-Taguchi, António M Fernandes, Margit Böhler, Ina Schmitt, Lena Tittel, Wolfgang Driever
Dopaminergic neurons of the descending diencephalospinal system are located in the posterior tuberculum (PT) in zebrafish ( Danio rerio ), and correspond in mammals to the A11 group in hypothalamus and thalamus. In the larval zebrafish, they are likely the only source of central dopaminergic projections to the periphery. Here, we characterized posterior tubercular dopaminergic fibers projecting to peripheral sense organs, with a focus on the lateral line neuromasts. We labeled and identified catecholaminergic neurons and their projections by combining two immunofluorescence techniques, (i) using an antibody against Tyrosine hydroxylase, and (ii) using an antibody against GFP in transgenic zebrafish expressing in catecholaminergic neurons either membrane-anchored GFP to track fibers, or a Synaptophysin-GFP fusion to visualize putative synapses...
2018: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/29614352/the-place-of-gamma-knife-stereotactic-radiosurgery-in-grade-4-vestibular-schwannoma-based-on-a-case-series-of-86-patients-with-long-term-follow-up
#14
M Lefranc, Leila Maria Da Roz, Anne Balossier, J M Thomassin, P H Roche, J Regis
INTRODUCTION: Grade IV vestibular schwannoma (Koos classification) is generally considered to be an indication for microsurgical resection or combined radiosurgery-microsurgery. However, the place of Gamma knife stereotactic surgery (GK-SRS), either as first-line treatment or when progression of residual tumor compresses the brainstem, has not been clearly evaluated. This article reports the results of a large case series of patients with grade 4 vestibular schwannoma treated by GK-SRS...
March 31, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29608482/posterior-fossa-re-exploration-for-recurrent-trigeminal-neuralgia-operative-findings-and-surgical-techniques
#15
Bao-Hui Feng, Xu-Hui Wang, Shi-Ting Li
OBJECTIVE: Microvascular decompression (MVD) is considered the first choice for the surgical treatment of trigeminal neuralgia (TN). However, recurrence after MVD is still a problem and a challenge for neurosurgeons. In this study, we share our experience in the posterior fossa re-exploration of the recurrent cases. METHODS: From January 2014 to January 2015, 15 recurrent TN patients who received fossa re-exploration were retrospectively studied. Surgeries were performed by retrosigmoid suboccipital approach...
March 30, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29608477/cardiac-arrest-and-death-attributable-to-the-diving-response-triggered-during-incision-and-debridement-of-an-abscess-of-the-forehead
#16
Steven M Kane, Jacob Davis
The authors discuss about a patient who, while undergoing a routine procedure to drain a subcutaneous abscess within his forehead, suffered cardiac arrest that we conclude was caused by an activation of the diving response. This reflex affects homeostatic function which alters respiration and preferentially distributes oxygen stores to the heart and brain. Under some conditions, however, this reflex can also trigger cardiovascular collapse and death. The diving reflex is can begin with triggering receptors that are sensitive to cold water, submersion, or pressure within the nasal cavity and other areas supplied by the trigeminal nerve...
March 30, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29603737/clinical-presentation-and-magnetic-resonance-imaging-findings-in-11-dogs-with-eosinophilic-meningoencephalitis-of-unknown-aetiology
#17
T J A Cardy, I Cornelis
OBJECTIVES: To describe the clinical presentation, MRI findings and outcome in dogs with eosinophilic meningoencephalitis of unknown origin. MATERIALS AND METHODS: Dogs were included in this retrospective study if they had complete medical records, complete neurological examination, MR imaging, cerebellomedullary cerebrospinal fluid sample consistent with eosinophilic pleocytosis and negative infectious disease testing. RESULTS: Eleven dogs were included with a median age of 22·0 months (range 7·6 to 92·0 months)...
March 30, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29600170/is-marcus-gunn-jaw-winking-a-primitive-reflex-rat-neuroanatomy
#18
Hou-Cheng Liang, Jing-Dong Zhang, Pi-Fu Luo, Ying Qiao, An-Le Su, Ting Zhang, Hong-Na Zhu
AIM: To investigate a possible trigeminal proprioceptive-oculomotor neural pathway and explore possible synaptic connections between neurons in this pathway. Attempt to bring a new insight to mechanism of Marcus Gunn syndrome (MGS). METHODS: Anterograde and retrograde tract tracing was applied and combined with immunofluorescent stain in rats. After electrophysiological identifying mesencephalic trigeminal nucleus (Vme) neurons, intracellular injection of tracer was performed to trace axon trajectory...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29588984/effect-of-neurostimulation-on-cognition-and-mood-in-refractory-epilepsy
#19
REVIEW
Alvin Y Chan, John D Rolston, Vikram R Rao, Edward F Chang
Epilepsy is a common, debilitating neurological disorder characterized by recurrent seizures. Mood disorders and cognitive deficits are common comorbidities in epilepsy that, like seizures, profoundly influence quality of life and can be difficult to treat. For patients with refractory epilepsy who are not candidates for resection, neurostimulation, the electrical modulation of epileptogenic brain tissue, is an emerging treatment alternative. Several forms of neurostimulation are currently available, and therapy selection hinges on relative efficacy for seizure control and amelioration of neuropsychiatric comorbidities...
March 2018: Epilepsia Open
https://www.readbyqxmd.com/read/29588250/a-novel-role-for-lymphotactin-xcl1-signalling-in-the-nervous-system-xcl1-acts-via-its-receptor-xcr1-to-increase-trigeminal-neuronal-excitability
#20
Emma V Bird, Tommaso Iannitti, Claire R Christmas, Ilona Obara, Veselin I Andreev, Anne E King, Fiona M Boissonade
Chemokines are known to have a role in the nervous system, influencing a range of processes including the development of chronic pain. To date there are very few studies describing the functions of the chemokine lymphotactin (XCL1) or its receptor (XCR1) in the nervous system. We investigated the role of the XCL1-XCR1 axis in nociceptive processing, using a combination of immunohistochemical, pharmacological and electrophysiological techniques. Expression of XCR1 in the rat mental nerve was elevated 3 days following chronic constriction injury (CCI), compared with 11days post-CCI and sham controls...
March 24, 2018: Neuroscience
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