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Neonatal pulmonary haemorrhage

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https://www.readbyqxmd.com/read/27790540/a-randomized-trial-comparing-efficacy-of-bubble-and-ventilator-derived-nasal-cpap-in-very-low-birth-weight-neonates-with-respiratory-distress
#1
Sheetal Agarwal, Arti Maria, Mahesh K Roy, Ankit Verma
INTRODUCTION: Continuous Positive Airway Pressure (CPAP) has an established role in the care of Very Low Birth Weight (VLBW) babies with respiratory distress. Bubble CPAP (BCPAP) is a cheap alternative for countries where resources are limited. However, data comparing efficacy of BCPAP with conventional ventilator derived (VCPAP) is limited. AIM: To compare CPAP failure rates between BCPAP and VCPAP among VLBW, with moderate respiratory distress. Secondary objectives were to compare the rates of Intraventricular Haemorrhage (IVH), pulmonary air leaks and deaths between the two groups and determine the predictors of CPAP failure...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27780154/maternal-and-neonatal-outcomes-following-expectant-management-of-preterm-prelabour-rupture-of-membranes-before-viability
#2
Winnie Huiyan Sim, Edward Araujo Júnior, Fabricio Da Silva Costa, Penelope Marie Sheehan
AIM: To assess the contemporary maternal and neonatal outcomes following expectant management of preterm premature rupture of membranes (PPROM) prior to 24 weeks' gestation and to identify prognostic indicators of this morbid presentation. METHODS: We performed a systematic review in the Pubmed and EMBASE databases to identify the primary (perinatal mortality, severe neonatal morbidity and serious maternal morbidity) and secondary (neonatal survival and morbidity) outcomes following expectant management of previable PPROM...
October 25, 2016: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27599834/case-report-of-a-central-venous-access-device-associated-thrombosis-with-aortic-embolism-in-a-preterm-infant
#3
Marlene Biermayr, Barbara Brunner, Kathrin Maurer, Rudolf Trawoeger, Ursula Kiechl-Kohlendorfer, Vera Neubauer
BACKGROUND: Thrombosis in neonates is commonly a central venous access device (CVAD) associated complication. Furthermore, a patent foramen ovale (PFO) is frequently seen in preterm infants. Even though a coincidence of both is not unusual, detaching of the thrombus and organisation of an aortic embolism has not been described until now. Treatment recommendations of CVAD-associated thrombosis in neonates do not consider frequently seen complications of preterm infants e.g. intraventricular haemorrhage...
2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27581993/synchronized-mechanical-ventilation-for-respiratory-support-in-newborn-infants
#4
Anne Greenough, Thomas E Rossor, Adesh Sundaresan, Vadivelam Murthy, Anthony D Milner
BACKGROUND: During synchronised mechanical ventilation, positive airway pressure and spontaneous inspiration coincide. If synchronous ventilation is provoked, adequate gas exchange should be achieved at lower peak airway pressures, potentially reducing baro/volutrauma, air leak and bronchopulmonary dysplasia. Synchronous ventilation can potentially be achieved by manipulation of rate and inspiratory time during conventional ventilation and employment of patient-triggered ventilation. OBJECTIVES: To compare the efficacy of:(i) synchronised mechanical ventilation, delivered as high-frequency positive pressure ventilation (HFPPV) or patient-triggered ventilation (assist control ventilation (ACV) and synchronous intermittent mandatory ventilation (SIMV)), with conventional ventilation or high-frequency oscillation (HFO);(ii) different types of triggered ventilation (ACV, SIMV, pressure-regulated volume control ventilation (PRVCV), SIMV with pressure support (PS) and pressure support ventilation (PSV))...
September 1, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27540237/medication-management-of-the-extremely-premature-neonate-the-impact-of-a-specialist-pharmacist
#5
Karen Whitfield, Claudia Barkeij, Angela North
AIM: To present a case of an extremely premature infant and the role that the specialist neonatal pharmacist has on the quality of care of these patients. METHOD: Interventions and recommendations made by the pharmacists over the admission of a triplet born at 23 weeks and 5 days gestation were recorded. The type of interventions were categorised and classified for risk using a consequence/probability matrix.1 RESULTS: The patient required admission to the intensive care unit and subsequently the special care unit for a period of 163 days before discharge home...
September 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27539719/synchronized-mechanical-ventilation-for-respiratory-support-in-newborn-infants
#6
REVIEW
Anne Greenough, Vadivelam Murthy, Anthony D Milner, Thomas E Rossor, Adesh Sundaresan
BACKGROUND: During synchronised mechanical ventilation, positive airway pressure and spontaneous inspiration coincide. If synchronous ventilation is provoked, adequate gas exchange should be achieved at lower peak airway pressures, potentially reducing baro/volutrauma, air leak and bronchopulmonary dysplasia. Synchronous ventilation can potentially be achieved by manipulation of rate and inspiratory time during conventional ventilation and employment of patient-triggered ventilation. OBJECTIVES: To compare the efficacy of:(i) synchronised mechanical ventilation, delivered as high-frequency positive pressure ventilation (HFPPV) or patient-triggered ventilation (assist control ventilation (ACV) and synchronous intermittent mandatory ventilation (SIMV)), with conventional ventilation or high-frequency oscillation (HFO);(ii) different types of triggered ventilation (ACV, SIMV, pressure-regulated volume control ventilation (PRVCV), SIMV with pressure support (PS) and pressure support ventilation (PSV))...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27384151/sealing-procedures-for-preterm-prelabour-rupture-of-membranes
#7
REVIEW
Adele E Crowley, Rosalie M Grivell, Jodie M Dodd
BACKGROUND: Preterm prelabour rupture of the membranes (PPROM) complicates approximately 2% of pregnancies and can be either spontaneous or iatrogenic in nature. Complications of PPROM include prematurity, chorioamnionitis, neonatal sepsis, limb position defects, respiratory distress syndrome, pulmonary hypoplasia chronic lung disease, periventricular leukomalacia and intraventricular haemorrhage.A number of different sealing techniques have been employed which aim to restore a physical barrier against infection and encourage the re-accumulation of amniotic fluid...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27148674/heparin-for-the-prevention-of-intraventricular-haemorrhage-in-preterm-infants
#8
REVIEW
Matteo Bruschettini, Olga Romantsik, Simona Zappettini, Rita Banzi, Luca Antonio Ramenghi, Maria Grazia Calevo
BACKGROUND: Preterm birth remains the major risk factor for the development of intraventricular haemorrhage, an injury that occurs in 25% of very low birth weight infants. Intraventricular haemorrhage is thought to be venous in origin and intrinsic thromboses in the germinal matrix are likely to play a triggering role. Heparin activates antithrombin and promotes the inactivation of thrombin and other target proteinases. The administration of anticoagulants such as heparin may offset the increased risk of developing intraventricular haemorrhage and may also reduce the risk of developing parenchymal venous infarct, a condition known to complicate intraventricular haemorrhage...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26939749/transcatheter-stenting-of-the-right-ventricular-outflow-tract-augments-pulmonary-arterial-growth-in-symptomatic-infants-with-right-ventricular-outflow-tract-obstruction-and-hypercyanotic-spells
#9
Eimear McGovern, Conall T Morgan, Paul Oslizlok, Damien Kenny, Kevin P Walsh, Colin J McMahon
We retrospectively reviewed all the children with right ventricular outflow tract obstruction, hypoplastic pulmonary annulus, and pulmonary arteries who underwent stenting of the right ventricular outflow tract for hypercyanotic spells at our institution between January, 2008 and December, 2013; nine patients who underwent cardiac catheterisation at a median age of 39 days (range 12-60 days) and weight of 3.6 kg (range 2.6-4.3 kg) were identified. The median number of stents placed was one stent (range 1-4)...
October 2016: Cardiology in the Young
https://www.readbyqxmd.com/read/26823208/do-knowledge-of-uterine-artery-resistance-in-the-second-trimester-and-targeted-surveillance-improve-maternal-and-perinatal-outcome-utopia-study-a-randomized-controlled-trial
#10
B García, E Llurba, L Valle, M D Gómez-Roig, M Juan, C Pérez-Matos, M Fernández, J A García-Hernández, J Alijotas-Reig, M T Higueras, I Calero, M Goya, S Pérez-Hoyos, E Carreras, L Cabero
OBJECTIVES: To ascertain whether screening for pre-eclampsia (PE) and intrauterine growth restriction (IUGR) by uterine artery (UtA) Doppler in the second trimester of pregnancy and targeted surveillance improve maternal and perinatal outcomes in an unselected population. METHODS: This was a multicenter randomized open-label controlled trial. At the routine second-trimester anomaly scan, women were assigned randomly to UtA Doppler or non-Doppler groups. Women with abnormal UtA Doppler were offered intensive surveillance at high-risk clinics of the participating centers with visits every 4 weeks that included measurement of maternal blood pressure, dipstick proteinuria, fetal growth and Doppler examination...
June 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/26510725/double-blind-randomised-placebo-controlled-trial-to-evaluate-the-efficacy-of-esomeprazole-to-treat-early-onset-pre-eclampsia-pie-trial-a-study-protocol
#11
RANDOMIZED CONTROLLED TRIAL
Catherine A Cluver, Susan P Walker, Ben W Mol, Gerard B Theron, David R Hall, Richard Hiscock, N Hannan, S Tong
INTRODUCTION: Pre-eclampsia is a major complication of pregnancy, globally responsible for 60 000 maternal deaths per year, and far greater numbers of fetal losses. There is no definitive treatment other than delivery. A drug that can quench the disease process could be useful to treat early onset pre-eclampsia, as it could allow pregnancies to safely continue to a gestation where fetal outcomes are significantly improved. We have generated preclinical data to show esomeprazole, a proton pump inhibitor used for gastric reflux, has potent biological effects that makes it a worthwhile therapeutic candidate...
2015: BMJ Open
https://www.readbyqxmd.com/read/26474355/rescue-high-frequency-jet-ventilation-versus-conventional-ventilation-for-severe-pulmonary-dysfunction-in-preterm-infants
#12
REVIEW
Maria Ximena Rojas-Reyes, Paola A Orrego-Rojas
BACKGROUND: Chronic lung disease (CLD) is a major cause of mortality and morbidity in very low birth weight infants despite increased use of antenatal steroids and surfactant therapy. Ventilator injury and oxygen toxicity are thought to be important factors in the pathogenesis of chronic pulmonary disease. Evidence from animal studies and from adult human studies indicates that high-frequency jet ventilation may reduce the severity of lung injury associated with mechanical ventilation...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26253166/neonatal-deaths-prospective-exploration-of-the-causes-and-process-of-end-of-life-decisions
#13
MULTICENTER STUDY
Jonathan Hellmann, Robin Knighton, Shoo K Lee, Prakesh S Shah
OBJECTIVE: To determine the causes and process of death in neonates in Canada. DESIGN: Prospective observational study. SETTING: Nineteen tertiary level neonatal units in Canada. PARTICIPANTS: 942 neonatal deaths (215 full-term and 727 preterm). EXPOSURE AND OUTCOME: Explored the causes and process of death using data on: (1) the rates of withdrawal of life-sustaining treatment (WLST); (2) the reasons for raising the issue of WLST; (3) the extent of consensus with parents; (4) the consensual decision-making process both with parents and the multidisciplinary team; (5) the elements of WLST; and (6) the age at death and time between WLST and actual death...
March 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/26144860/pulmonary-haemorrhage-due-to-an-aortopulmonary-collateral-artery-after-arterial-switch
#14
Ai Sugimoto, Noritaka Ota, Kisaburo Sakamoto
A neonate with transposition of the great arteries and intact ventricular septum presented without pulmonary over-circulation, and subsequently developed pulmonary haemorrhage after corrective surgery. Postoperative CT revealed an aortopulmonary collateral artery arising from the descending aorta, and we performed successful embolisation on postoperative day 9. Aggressive imaging modalities such as angiography and/or CT imaging with contrast can detect unexpected extra-pulmonary blood supply and guide further management...
March 2016: Cardiology in the Young
https://www.readbyqxmd.com/read/26068354/kluyvera-ascorbata-sepsis-in-an-extremely-low-birth-weight-infant
#15
D Sharma, T Dasi, S Murki, T P Oleti
Kluyvera ascorbata belongs to Enterobacteriaceae family and is a gram negative micro-organism. This bacteria is usually considered a commensal, however it can cause significant infections rarely. This organism is usually resistant to most commonly used antibiotics used as first line in neonatal units. Antimicrobial agents active against Kluyvera strains include third-generation cephalosporins, fluoroquinolones, and aminoglycosides. We report a case of an extremely low birth weight male infant who presented on day 4 of life with clinical features of sepsis, multi-organ dysfunction, shock and pulmonary haemorrhage...
July 2015: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/25989175/haemorrhagic-pneumonia-caused-by-stenotrophomonas-maltophilia-in-two-newborns
#16
Nilufer Guzoglu, Fatma Nur Demirkol, Didem Aliefendioglu
Invasive procedures and antibiotic treatment increase the risk of nosocomial infections in neonatal intensive care units. Early identification and appropriate treatment is important. Herein we report two cases of massive hemorrhagic pneumonia caused by Stenotrophomonas maltophilia. The first case was diagnosed with congenital pneumonia; a chest tube was inserted because of pneumothorax on the third day of life. The second case had been referred with respiratory distress syndrome, and bilateral pneumothorax was present on admission...
May 2015: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/25785789/elective-high-frequency-oscillatory-ventilation-versus-conventional-ventilation-for-acute-pulmonary-dysfunction-in-preterm-infants
#17
REVIEW
Filip Cools, Martin Offringa, Lisa M Askie
BACKGROUND: Respiratory failure due to lung immaturity is a major cause of mortality in preterm infants. Although the use of intermittent positive pressure ventilation (IPPV) in neonates with respiratory failure saves lives, its use is associated with lung injury and chronic lung disease. A newer form of ventilation called high frequency oscillatory ventilation has been shown in experimental studies to result in less lung injury. OBJECTIVES: The objective of this review was to determine the effect of the elective use of high frequency oscillatory ventilation (HFOV) as compared to conventional ventilation (CV) on the incidence of chronic lung disease (CLD), mortality and other complications associated with prematurity and assisted ventilation in preterm infants who were mechanically ventilated for respiratory distress syndrome (RDS)...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25622597/haemoglobin-level-at-birth-is-associated-with-short-term-outcomes-and-mortality-in-preterm-infants
#18
Jayanta Banerjee, Felix K Asamoah, Devpriya Singhvi, Angela W G Kwan, Joan K Morris, Narendra Aladangady
BACKGROUND: Blood volume and haemoglobin (Hb) levels are increased by delayed umbilical cord clamping, which has been reported to improve clinical outcomes of preterm infants. The objective was to determine whether Hb level at birth was associated with short term outcomes in preterm infants born at ≤32 weeks gestation. METHODS: Data were collected retrospectively from electronic records: Standardised Electronic Neonatal Database, Electronic Patient Record, Pathology (WinPath), and Blood Bank Electronic Database...
2015: BMC Medicine
https://www.readbyqxmd.com/read/25567562/risk-factor-profile-of-massive-pulmonary-haemorrhage-in-neonates-the-impact-on-survival-studied-in-a-tertiary-care-centre
#19
Sook Kyung Yum, Cheong-Jun Moon, Young-Ah Youn, Hyun Seung Lee, So-Young Kim, In Kyung Sung
OBJECTIVE: Pulmonary haemorrhage (PH) in neonates is a fatal event leading to hazardous complications and even death. The aim of this study was to elucidate influential factors of the ultimate disease course that affect death or survival. METHODS: Infants treated for PH in our institution from March 2009 to December 2013 were retrospectively reviewed. Infants transferred from other hospitals were excluded. Infants were grouped into two categories, deceased or survived at neonatal intensive care unit discharge...
2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/25504256/surfactant-for-meconium-aspiration-syndrome-in-term-and-late-preterm-infants
#20
REVIEW
Amr I El Shahed, Peter A Dargaville, Arne Ohlsson, Roger Soll
BACKGROUND: Surfactant replacement therapy has been proven beneficial in the prevention and treatment of neonatal respiratory distress syndrome (RDS). The deficiency of surfactant or surfactant dysfunction may contribute to respiratory failure in a broader group of disorders, including meconium aspiration syndrome (MAS). OBJECTIVES: To evaluate the effect of surfactant administration in the treatment of late preterm and term infants with meconium aspiration syndrome...
2014: Cochrane Database of Systematic Reviews
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