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https://www.readbyqxmd.com/read/27914008/igf1r-dental-pulp-stem-cells-enhanced-neuroplasticity-in-hypoxia-ischemia-model
#1
Hsiao-Yu Chiu, Chen-Huan Lin, Chung Y Hsu, John Yu, Chia-Hung Hsieh, Woei-Cherng Shyu
Until now, the surface markers of multipotent mesenchymal stem cells (MSCs) had not been fully identified. Here, we found that the IGF1 receptor (IGF1R), regarded as a pluripotent marker of embryonic stem cells (ESCs), was also expressed in human dental pulp derived-mesenchymal stem cells (hDSCs), which displayed a potential for both self-renewal and multipotency. hDSC-secreted IGF1 interacted with IGF1R through an autocrine signaling pathway to maintain this self-renewal and proliferation potential. Stereotaxic implantation of immunosorted IGF1R(+) hDSCs in rats with neonatal hypoxia-ischemia (NHI) promoted neuroplasticity, improving the neurological outcome by increasing expression of the anti-apoptotic protein Bcl-2, which enhanced both neurogenesis and angiogenesis...
December 2, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27912815/regenerative-endodontics-by-cell-homing
#2
REVIEW
Ling He, Juan Zhong, Qimei Gong, Bin Cheng, Sahng G Kim, Junqi Ling, Jeremy J Mao
Apical revascularization (AR) and platelet-rich plasma have been used to restore dental pulp vitality in infected immature permanent teeth. Two regenerative therapies are cell transplantation and cell homing. This article updates and benchmarks these therapies with cell homing. A case report concluded that AR increased root length; however, quantitative and statistical assessments disproved this. Regenerative endodontic therapies require prospective clinical trials demonstrating safety and efficacy. These therapies are intrinsically susceptible to procedural and patient variations...
January 2017: Dental Clinics of North America
https://www.readbyqxmd.com/read/27912814/biological-molecules-for-the-regeneration-of-the-pulp-dentin-complex
#3
REVIEW
Sahng G Kim
Regenerative endodontic treatment has yielded excellent clinical outcomes, but only several animal studies have shown the robust regeneration of the pulp-dentin complex. The biological molecules, if properly delivered, can enkindle regeneration of dental pulp and dentin rather than repair with tissues of periodontal origin. This review details the biological significance of regenerating the pulp-dentin complex, the effects of biological cues in pulp regeneration, and the delivery strategies of biological molecules to enhance the outcomes of regenerative endodontic therapy...
January 2017: Dental Clinics of North America
https://www.readbyqxmd.com/read/27905856/1-25-dihydroxyvitamin-d3-stimulates-odontoblastic-differentiation-of-human-dental-pulp-stem-cells-in-vitro
#4
Goksen Mucuk, Elif Sepet, Mine Erguven, Ozlem Ekmekci, Ayhan Bilir
BACKGROUND: 1,25-dihydroxyvitamin D3 (1,25-OH D3) plays an important role in mineralized tissue metabolism, including teeth. However, few studies have addressed its role in odontoblastic differentiation of human dental pulp-stem cells (hDPSCs). AIM: This study aimed to understand the influence of various concentrations of 1,25-OH D3 on the proliferation capacity and early dentinogenesis responses of hDPSCs. MATERIALS AND METHODS: hDPSCs were obtained from the impacted third molar teeth...
December 1, 2016: Connective Tissue Research
https://www.readbyqxmd.com/read/27905673/single-versus-multiple-visits-for-endodontic-treatment-of-permanent-teeth
#5
REVIEW
Maddalena Manfredi, Lara Figini, Massimo Gagliani, Giovanni Lodi
BACKGROUND: Root canal treatment (RoCT), or endodontic treatment, is a common procedure in dentistry. The main indications for RoCT are irreversible pulpitis and necrosis of the dental pulp caused by carious processes, tooth cracks or chips, or dental trauma. Successful RoCT is characterised by an absence of symptoms (i.e. pain) and clinical signs (i.e. swelling and sinus tract) in teeth without radiographic evidence of periodontal involvement (i.e. normal periodontal ligament). The success of RoCT depends on a number of variables related to the preoperative condition of the tooth, as well as the endodontic procedures...
December 1, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27901202/in-vivo-performance-of-different-scaffolds-for-dental-pulp-stem-cells-induced-for-odontogenic-differentiation
#6
Cigdem Atalayin, Huseyin Tezel, Taner Dagci, Nefise Ulku Karabay Yavasoglu, Gulperi Oktem, Timur Kose
This study was designed to determine the in vivo performance of three different materials as scaffolds for dental pulp stem cells (DPSC) undergoing induced odontogenic differentiation. An odontogenic medium modified by the addition of recombinant human bone morphogenetic protein 2 was used in the experimental groups to induce differentiation. Mesenchymal stem cell medium was used in the control groups. DPSC were transplanted onto the backs of mice via three scaffolds: copolymer of L-lactide and DL-lactide (PLDL), copolymer of DL-lactide (PDL) and hydroxyapatite tricalcium phosphate (HA/TCP)...
November 28, 2016: Brazilian Oral Research
https://www.readbyqxmd.com/read/27892627/withdrawn-pulp-management-for-caries-in-adults-maintaining-pulp-vitality
#7
REVIEW
Hiroshi Miyashita, Helen V Worthington, Alison Qualtrough, Alphons Plasschaert
BACKGROUND: There is a range of treatment options for the management of the pulp in extensively decayed teeth. These include direct and indirect pulp capping, pulpotomy or pulpectomy. If the tooth is symptomatic or if there are periapical bone changes, then endodontic treatment is required. However, if the tooth is asymptomatic but the caries is extensive, there is no consensus as to the best method of management. In addition, there has been a recent move towards using alternative materials and methods such as the direct or indirect placement of bonding agents and mineral trioxide aggregate...
November 28, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27891629/capping-carious-exposures-in-adults-a-randomized-controlled-trial-investigating-mineral-trioxide-aggregate-versus-calcium-hydroxide
#8
R Kundzina, L Stangvaltaite, H M Eriksen, E Kerosuo
AIM: The aim of this multicentre, parallel-group randomized clinical trial was to compare the effectiveness of mineral trioxide aggregate (MTA) and a conventional calcium hydroxide liner (CH) as direct pulp capping materials in adult molars with carious pulpal exposure. METHODOLOGY: Seventy adults aged 18-55 years were randomly allocated to two parallel arms: MTA (White ProRoot, Dentsply, Tulsa Dental, Tulsa, OK, USA; n = 33) and CH (Dycal(®) , Dentsply DeTrey GmbH, Konstanz, Germany; n = 37)...
November 7, 2016: International Endodontic Journal
https://www.readbyqxmd.com/read/27890225/applications-of-mesenchymal-stem-cells-in-oral-and-craniofacial-regeneration
#9
REVIEW
Pasha Shakoori, Quanzhou Zhang, Anh D Le
The field of tissue engineering and regenerative medicine has been rapidly expanded through multidisciplinary integration of research and clinical practice in response to unmet clinical needs for reconstruction of dental, oral, and craniofacial structures. The significance of the various types of stem cells, specifically mesenchymal stem cells derived from the orofacial tissues, ranging from dental pulp stem cells to periodontal ligament stem cells to mucosa/gingiva has been thoroughly investigated and their applications in tissue regeneration are outlined in this article...
February 2017: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/27883224/basic-fibroblast-growth-factor-regulates-rex1-expression-via-il-6-in-stem-cells-isolated-from-human-exfoliated-deciduous-teeth
#10
Nunthawan Nowwarote, Waleerat Sukarawan, Prasit Pavasant, Thanaphum Osathanon
Basic fibroblast growth factor (bFGF) regulates pluripotent marker expression and cellular differentiation in various cell types. However, the mechanism by which bFGF regulates REX1 expression in stem cells isolated from human exfoliated deciduous teeth (SHEDs) remains unclear. The aim of the present study was to investigate the regulation of REX1 expression by bFGF in SHEDs. SHEDs were isolated and characterized. Their mRNA and protein expression levels were determined using real-time polymerase chain reaction and enzyme-linked immunosorbent assay, respectively...
November 24, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27883188/structural-organization-and-tooth-development-in-a-homo-aff-erectus-juvenile-mandible-from-the-early-pleistocene-site-of-garba-iv-at-melka-kunture-ethiopian-highlands
#11
Clément Zanolli, M Christopher Dean, Yared Assefa, Priscilla Bayle, José Braga, Silvana Condemi, Metasebia Endalamaw, Blade Engda Redae, Roberto Macchiarelli
OBJECTIVES: The immature partial mandible GAR IVE from the c. 1.7 Ma old Garba IV site at Melka Kunture (Upper Awash Basin, Ethiopia), the earliest human representative from a mountain-like environment, represents one of the oldest early Homo specimens bearing a mixed dentition. Following its first description (Condemi, ), we extended the analytical and comparative record of this specimen by providing unreported details about its inner morphology, tooth maturational pattern and age at death, crown size, and tooth tissue proportions...
November 24, 2016: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/27877132/immunophenotyping-reveals-the-diversity-of-human-dental-pulp-mesenchymal-stromal-cells-in-vivo-and-their-evolution-upon-in-vitro-amplification
#12
Maxime Ducret, Hugo Fabre, Olivier Degoul, Gianluigi Atzeni, Colin McGuckin, Nico Forraz, Frédéric Mallein-Gerin, Emeline Perrier-Groult, Brigitte Alliot-Licht, Jean-Christophe Farges
Mesenchymal stromal/stem cells (MSCs) from human dental pulp (DP) can be expanded in vitro for cell-based and regenerative dentistry therapeutic purposes. However, their heterogeneity may be a hurdle to the achievement of reproducible and predictable therapeutic outcomes. To get a better knowledge about this heterogeneity, we designed a flow cytometric strategy to analyze the phenotype of DP cells in vivo and upon in vitro expansion with stem cell markers. We focused on the CD31(-) cell population to exclude endothelial and leukocytic cells...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27874916/treatment-options-for-permanent-teeth-with-deep-caries
#13
Monika Marending, Thomas Attin, Matthias Zehnder
The goal of this narrative review was to summarize and compare treatment options for permanent teeth carious lesions that are radiographically close to the pulp chamber. Thanks to adhesive restorative materials, minimally invasive approaches are possible. In this context, the old question arises as to whether caries must be excavated completely, i.e., down to hard dentin, or whether it could be advantageous to leave some soft dentin, or even merely seal the whole lesion. To answer this question, the microbiological aspects of the lesion must be considered, along with the immunological response in the dental pulp, with the concurrent possible negative outcomes for the patient...
2016: Swiss Dental Journal
https://www.readbyqxmd.com/read/27871783/human-dental-pulp-stem-cells-suppress-alloantigen-induced-immunity-by-stimulating-t-cells-to-release-transforming-growth-factor-beta
#14
Kyu Hwan Kwack, Jung Min Lee, Sang Hyuk Park, Hyeon Woo Lee
INTRODUCTION: Human dental pulp stem cells (hDPSCs) are ideal candidates for regenerating damaged dental tissue. To examine the possibility that hDPSCs may be used to regenerate pulp, we tested their in vitro effects on acute allogeneic immune responses. METHODS: A peripheral blood mononuclear cell (PBMC) proliferation assay and immunoglobulin (Ig) production assay were performed to evaluate the immunosuppressive properties of hDPSCs. RESULTS: The mixed lymphocyte reaction was suppressed by incubation with hDPSCs...
November 18, 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/27871480/release-of-growth-factors-into-root-canal-by-irrigations-in-regenerative-endodontics
#15
Qian Zeng, Sean Nguyen, Hongming Zhang, Hari Priya Chebrolu, Dalia Alzebdeh, Mustafa A Badi, Jong Ryul Kim, Junqi Ling, Maobin Yang
INTRODUCTION: The aim of this study was to investigate the release of growth factors into root canal space after the irrigation procedure of regenerative endodontic procedure. METHODS: Sixty standardized root segments were prepared from extracted single-root teeth. Nail varnish was applied to all surfaces except the root canal surface. Root segments were irrigated with 1.5% NaOCl + 17% EDTA, 2.5% NaOCl + 17% EDTA, 17% EDTA, or deionized water. The profile of growth factors that were released after irrigation was studied by growth factor array...
December 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/27871176/in-vivo-angiogenic-capacity-of-stem-cells-from-human-exfoliated-deciduous-teeth-with-human-umbilical-vein-endothelial-cells
#16
Ji-Hye Kim, Gee-Hye Kim, Jae-Won Kim, Hee Jang Pyeon, Jae Cheoun Lee, Gene Lee, Hyun Nam
Dental pulp is a highly vascularized tissue requiring adequate blood supply for successful regeneration. In this study, we investigated the functional role of stem cells from human exfoliated deciduous teeth (SHEDs) as a perivascular source for in vivo formation of vessel-like structures. Primarily isolated SHEDs showed mesenchymal stem cell (MSC)-like characteristics including the expression of surface antigens and in vitro osteogenic and adipogenic differentiation potentials. Moreover, SHEDs were positive for NG2, α-smooth muscle actin (SMA), platelet-derived growth factor receptor beta (PDGFRβ), and CD146 as pericyte markers...
November 30, 2016: Molecules and Cells
https://www.readbyqxmd.com/read/27863418/pin1-induces-the-adp-induced-migration-of-human-dental-pulp-cells-through-p2y1-stabilization
#17
Soo-A Kim, Hong Seok Choi, Sang-Gun Ahn
PIN1, which belongs to a family of prolyl isomerases, specifically binds to phosphorylated Ser/Thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. This study aimed to investigate the importance of Pin1 expression in human dental pulp cells (hDPCs) to understand the involvement of Pin1 in the regulation of P2Y1 and the activation of ADP-mediated P2Y1 signaling. This study found that the protein levels of P2Y1 gradually decreased after the onset of cell recovery following heat stress...
November 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27858058/-expression-of-opg-rank-rankl-in-the-rat-dental-pulp-tissue-of-periodontitis-combined-with-vascular-calcification-and-its-clinical-significance
#18
Ke-Qing Pan, Peng-Mei Zhang, Jing Deng, Xiu-Xiu Lou, Yun Meng, Gui-Rong Liu
PURPOSE: To study the expression and possible role of OPG/RANK/RANKLin the rat dental pulp of periodontitis combined with vascular calcification. METHODS: Thirty-six male Wister rats were randomly divided into 4 groups: control group(group C), periodontitis group(group CP), vascular calcification group(group VDN) and compound group(group CP+VDN). Each group underwent corresponding management to establish animal model. When the model was successful, the maxillae including molars were sectioned, pulp tissue was examined by H-E staining; Immunohistochemical staining method was used to evaluate the expression and ratio of OPG and RANKL in pulp tissues...
August 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/27857773/a-case-report-of-delayed-repositioning-of-intruded-permanent-maxillary-central-incisors-accompanied-by-complicated-crown-fractures-a-2-year-follow-up
#19
Azade Rafiee, Hamid Moradian, Maryam Ayatollahi
Intrusive luxation is the most severe type of dental injury with a complex healing sequence. Pulp necrosis, root resorption (surface, inflammatory and replacement resorption), and defects in marginal periodontal bone healing are the main complications. Treatment strategies can be either active, by repositioning (surgical or orthodontic extrusion), or passive, by spontaneous re-eruption based on the thorough evaluation of the case. This paper reports a case of delayed repositioning of severely intruded permanent maxillary central incisors accompanied by complicated crown fractures after 3 months...
September 2016: Dental Research Journal
https://www.readbyqxmd.com/read/27857514/the-use-of-bioceramics-in-endodontics-literature-review
#20
REVIEW
Stefan Jitaru, Ioana Hodisan, Lucia Timis, Anamaria Lucian, Marius Bud
BACKGROUND AND AIM: Bioceramics are ceramic compounds obtained both in situ and in vivo, by various chemical processes. Bioceramics exhibit excellent biocompatibility due to their similarity with biological materials, like hydroxyapatite. Bioceramics and multi-substituted hydroxyapatite or similar compounds have the ability to induce a regenerative response in the organism. The aim of this paper is to make a literature review on the main bioceramic materials currently used in endodontics and on their specific characteristics...
2016: Clujul Medical (1957)
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