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Staphyloccocus aureus

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https://www.readbyqxmd.com/read/29552454/phytochemical-screening-and-biological-activity-of-mentha-%C3%A3-piperita-l-and-lavandula-angustifolia-mill-extracts
#1
Ersilia Alexa, Corina Danciu, Isidora Radulov, Diana Obistioiu, Renata Maria Sumalan, Adriana Morar, Cristina Adriana Dehelean
The present study aimed to investigate the phytochemical composition of Mentha  ×  piperita L. (MP) and Lavandula angustifolia Mill. (LA) extracts in terms of hydroxycinnamic acid (HCAs) content, in particular, caffeic (CA), p-cumaric (CU), ferulic (FE), and rosmarinic (RS) acids using LC-MS. Also, the in vitro antimicrobial effect against Staphylococcus aureus and the antiproliferative activity against two cancerous cell lines (A375 and MDA-MB-231) using the MTT assay were tested. The extracts were prepared using aromatic water which resulted from the extraction of oils from plants as extraction medium, with/without acid...
2018: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/29524591/efficient-production-of-a-recombinant-venerupis-philippinarum-defensin-vpdef-in-pichia-pastoris-and-characterization-of-its-antibacterial-activity-and-stability
#2
De-Mei Meng, Yu-Jie Lv, Jing-Fang Zhao, Qing-Yan Liu, Lin-Yue Shi, Jun-Ping Wang, Yong-Hai Yang, Zhen-Chuan Fan
VpDef is a novel defensin isolated from the clam Venerupis philippinarum. Previously it was expressed in Escherichia coli; however, the E. coli-derived recombinant VpDef did not show effective antimicrobial activity against Staphyloccocus aureus or the Gram-negative bacteria tested. As such, the goal of this study was to design, express, and purify a recombinant VpDef (rVpDef) in Pichia pastoris and to determine its antibacterial potency and stability. A 6.9 KDa rVpDef was successfully expressed as a secreted peptide in P...
March 6, 2018: Protein Expression and Purification
https://www.readbyqxmd.com/read/29454901/methylene-blue-internalization-and-photodynamic-action-against-clinical-and-atcc-pseudomonas-aeruginosa-and-staphyloccocus-aureus-strains
#3
André Henrique Correia Pereira, Juliana Guerra Pinto, Mirian Aparecida Alves Freitas, Letícia Corrêa Fontana, Cristina Pacheco Soares, Juliana Ferreira-Strixino
Bacterial infections have been a major challenge to health studies, facing the increasingly resistance to antimicrobial agents, which according to World Health Organization, could be the major death cause until 2050. Photodynamic therapy emerges as an alternative in microbial inactivation, due to its selectivity and to decreasing or dismissing the antibiotic use. This study aimed at evaluating, in vitro, the internalization of the Methylene Blue and its photodynamic activity against a clinical and ATCC strain of Pseudomonas aeruginosa and Staphyloccocus aureus...
February 15, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29429584/differential-daptomycin-resistance-development-in-staphylococcus-aureus-strains-with-active-and-mutated-gra-regulatory-systems
#4
Anna Müller, Fabian Grein, Andreas Otto, Kathrin Gries, Dmitriy Orlov, Vladimir Zarubaev, Myriam Girard, Xinwei Sher, Olga Shamova, Terry Roemer, Patrice François, Dörte Becher, Tanja Schneider, Hans-Georg Sahl
The first-in-class lipopeptide antibiotic daptomycin (DAP) is highly active against Gram-positive pathogens including ß-lactam and glycopeptide resistant strains. Its molecular mode of action remains enigmatic, since a defined target has not been identified so far and multiple effects, primarily on the cell envelope have been observed. Reduced DAP susceptibility has been described in S. aureus and enterococci after prolonged treatment courses. In line with its pleiotropic antibiotic activities, a unique, defined molecular mechanism of resistance has not emerged, instead non-susceptibility appears often accompanied by alterations in membrane composition and changes in cell wall homeostasis...
December 21, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29353723/bysspectin-a-an-unusual-octaketide-dimer-and-the-precursor-derivatives-from-the-endophytic-fungus-byssochlamys-spectabilis-imm0002-and-their-biological-activities
#5
Yu-Zhuo Wu, Hua-Wei Zhang, Zhao-Hui Sun, Jun-Gui Dai, You-Cai Hu, Rui Li, Peng-Cheng Lin, Gui-Yang Xia, Ling-Yan Wang, Bo-Lin Qiu, Jing-Fang Zhang, Guang-Bo Ge, Sheng Lin
Bysspectin A (1), a polyketide-derived octaketide dimer with a novel carbon skeleton, and two new precursor derivatives, bysspectins B and C (2 and 3), were obtained from an organic extract of the endophytic fungus Byssochlamys spectabilis that had been isolated from a leaf tissue of the traditional Chinese medicinal plant Edgeworthia chrysantha, together with a known octaketide, paecilocin A (4). Their structures were determined by HRMS, 1D and 2D NMR spectroscopic analysis. A plausible route for their biosynthetic pathway is proposed...
February 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29244630/epidemiology-and-outcomes-of-bloodstream-infections-in-patients-with-solid-tumors-in-a-central-american-population-at-mexico-hospital-san-jose-costa-rica
#6
Jorge Calvo-Lon, Denis U Landaverde, Allan Ramos-Esquivel, Juan M Villalobos-Vindas
Purpose Bloodstream infections (BSIs) are an important cause of mortality in patients with solid tumors. We conducted a retrospective study to evaluate the epidemiologic profile and mortality of patients with solid tumors who have BSIs and were admitted to Mexico Hospital. This is the first study in Costa Rica and Central America describing the current epidemiologic situation. Methods We analyzed the infectious disease database for BSIs in patients with solid tumors admitted to Mexico Hospital from January 2012 to December 2014...
December 15, 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29242127/investigation-of-antibacterial-properties-of-novel-papain-immobilized-on-tannic-acid-modified-ag-cufe-2-o-4-magnetic-nanoparticles
#7
Keziban Atacan, Münteha Özacar, Mahmut Özacar
The non-toxic CuFe2 O4 magnetic nanoparticles have been solvothermally synthesized, characterized and used as an efficient magnetic precursor for papain immobilization and then investigated antibacterial properties of them. For increasing the antibacterial activity, the silver nanoparticles were doped on CuFe2 O4 magnetic nanoparticles. All prepared samples exhibited stronger antibacterial properties against Gram-positive bacteria (Staphyloccocus aureus) than Gram-negative bacteria (Escherichia coli). However, it was determined that the Ag/CuFe2 O4 had a more vigorous antibacterial property against the Staphyloccocus aureus bacteria by calculating the inhibition diameter of 25 ± 0...
April 1, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29211190/incidence-and-risk-factors-for-surgical-site-infection-in-general-surgeries
#8
Rafael Lima Rodrigues de Carvalho, Camila Cláudia Campos, Lúcia Maciel de Castro Franco, Adelaide De Mattia Rocha, Flávia Falci Ercole
OBJECTIVE: to estimate the incidence of surgical site infection in general surgeries at a large Brazilian hospital while identifying risk factors and prevalent microorganisms. METHOD: non-concurrent cohort study with 16,882 information of patients undergoing general surgery from 2008 to 2011. Data were analyzed by descriptive, bivariate and multivariate analysis. RESULTS: the incidence of surgical site infection was 3.4%. The risk factors associated with surgical site infection were: length of preoperative hospital stay more than 24 hours; duration of surgery in hours; wound class clean-contaminated, contaminated and dirty/infected; and ASA index classified into ASA II, III and IV/V...
December 4, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/29149185/linezolid-and-atorvastatin-impact-on-pneumonia-caused-by-staphyloccocus-aureus-in-rabbits-with-or-without-mechanical-ventilation
#9
Laure-Anne Pauchard, Mathieu Blot, Rémi Bruyere, Saber-Davide Barbar, Delphine Croisier, Lionel Piroth, Pierre-Emmanuel Charles
Pneumonia may involve methicillin-resistant Staphylococcus aureus (MRSA), with elevated rates of antibiotics failure. The present study aimed to assess the effect of statins given prior to pneumonia development. Spontaneously breathing (SB) or mechanically ventilated (MV) rabbits with pneumonia received atorvastatin alone, linezolid (LNZ) alone, or a combination of both (n = 5 in each group). Spontaneously breathing and MV untreated infected animals (n = 11 in each group), as well as uninfected animals (n = 5 in each group) were used as controls...
2017: PloS One
https://www.readbyqxmd.com/read/29104078/eucalyptus-robusta-leaves-methanolic-extract-suppresses-inflammatory-mediators-by-specifically-targeting-tlr4-tlr9-mpo-cox2-inos-and-inflammatory-cytokines-in-experimentally-induced-endometritis-in-rats
#10
Aastha Tiwari, Preeti Singh, Pooja Jaitley, Sushant Sharma, Atul Prakash, Rajesh Mandil, Soumen Choudhury, Neeraj Kumar Gangwar, Satish K Garg
ETHNOPHARMACOLOGICAL RELEVANCE: Bacterial endometritis is one of the major causes of reproductive disorders including infertility in farm animals. Antibiotics are generally used for treatment of such disorders but now a days residues of antibiotics are of great public health concern, therefore, phytoremediation is being considered as an alternative to use of antibiotics. AIM OF THE STUDY: Present study was undertaken to investigate the efficacy of Eucalyptus robusta leaves methanolic extract against endometritis along with the possible mechanism of action especially targeting inflammatory biomarkers...
March 1, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29045693/pharmacokinetics-of-ceftaroline-in-a-preterm-infant-with-methicillin-resistant-staphylococcus-aureus-pneumonia
#11
Sara N Salerno, Janice Bernhardt, Matthew Laughon, Ravi Jhaveri, Matthew Massaro, Daniel Gonzalez
We report here the first pharmacokinetic-pharmacodynamic relationship for ceftaroline in a preterm infant born at <28 weeks' gestational age who was given ceftaroline (8.5 mg/kg every 8 hours) for pneumonia attributable to methicillin-resistant Staphyloccocus aureus. This dose of ceftaroline was adequate to achieve the pharmacodynamic endpoint associated with efficacy for methicillin-resistant Staphyloccocus aureus.
October 16, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29020181/a-healthcare-improvement-intervention-combining-nucleic-acid-microarray-testing-with-direct-physician-response-for-management-of-staphylococcus-aureus-bacteremia
#12
Joshua C Eby, Morgan M Richey, James A Platts-Mills, Amy J Mathers, Wendy M Novicoff, Heather L Cox
Background: Nucleic acid microarray (NAM) testing for detection of Staphylococcus aureus bacteremia (SAB) and S. aureus resistance gene determinants can reduce time to targeted antibiotic administration. Evidence-based management of SAB includes bedside infectious diseases (ID) consultation. As a healthcare improvement initiative at our institution, with the goal of improving management and outcomes for subjects with SAB, we implemented NAM with a process for responding to positive NAM results by directly triggered, mandatory ID consultation...
January 6, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28916359/a-class-b-scavenger-receptor-from-eriocheir-sinensis-essr-b1-restricts-bacteria-proliferation-by-promoting-phagocytosis
#13
Yao-Meng Wu, Lei Yang, Xue-Jie Li, Lu Li, Qun Wang, Wei-Wei Li
Scavenger receptors (SRs) are important pattern recognition receptors (PRRs), which play significant roles in host defense against pathogens by identifying pathogen-associated molecular patterns (PAMPs). In this study, we report the cloning and characterization of a SR from Eriocheir sinensis (EsSR-B1) which is a 500 amino acid protein encoded by a gene comprised of 2726 nucleotides with a 1503 bp open reading frame. The domains of EsSR-B1 were found to be evolutionarily conserved. EsSR-B1 was widely detected in different tissues of E...
September 13, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28756021/association-of-clinical-severity-of-cystic-fibrosis-with-variants-in-the-slc-gene-family-slc6a14-slc26a9-slc11a1-and-slc9a3
#14
Stéphanie Villa-Nova Pereira, José Dirceu Ribeiro, Carmen Sílvia Bertuzzo, Fernando Augusto Lima Marson
INTRODUCTION: Cystic fibrosis (CF) manifests with clinical and histopathological variability depending on environmental and genetic factors. Moreover, the genes encoding ion channels[rs3788766(SLC6A14), rs7512462(SLC26A9), rs17235416(SLC11A1) and rs17563161(SLC9A3)] have been insufficiently studied as modifier genes. Then, our objective was associate the variants in the genes of SLC family with 43 CF severity markers. METHODS: The variants were identified by real-time-PCR in 188 CF patients considering the CFTR genotype...
September 20, 2017: Gene
https://www.readbyqxmd.com/read/28745896/carboxymethylpullulan-grafted-with-aminoguaiacol-synthesis-characterization-and-assessment-of-antibacterial-and-antioxidant-properties
#15
Marie-Carole Kouassi, Pascal Thébault, Christophe Rihouey, Emmanuelle Dé, Béatrice Labat, Luc Picton, Virginie Dulong
Aminoguaiacol, the aminated derivative of guaiacol, a natural phenolic compound, was chemically grafted onto a polysaccharide (carboxymethylpullulan, CMP) in the presence of the activator agent 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride (EDCI). The grafted polysaccharides were characterized by FTIR and (1)H NMR spectroscopy to confirm and quantify the grafting. All polysaccharide derivatives (grafting rates of aminoguaiacol between 16% and 58%) were soluble in water. Their physicochemical properties were studied in a dilute regime and a semidilute regime by light scattering, fluorescence, and rheology, showing associative properties with peculiar polysoap behavior...
September 1, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28647424/self-disinfecting-surfaces-and-activity-against-staphyloccocus-aureus-atcc-6538-under-real-life-conditions
#16
C Brühwasser, H Heinrich, C Lass-Flörl, A Mayr
Environmental surface contamination provides a potential reservoir for pathogens to cause infections. As such, self-disinfecting surfaces have been developed to possibly reduce exogenous transmission. Five different self-disinfecting surfaces were evaluated for activity against Staphylococcus aureus ATCC 6538 under real-life conditions using the dry inoculation method. Various antimicrobial effects were detected. However, following disinfection with alcoholic wipes, these effects disappeared. Further development is necessary to produce self-disinfecting surfaces that are stable in the presence of hospital disinfectants, as it is impossible to guarantee that self-disinfecting surfaces in healthcare settings will not be exposed to disinfectants...
June 22, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28494339/application-of-protein-a-modified-capillary-channeled-polymer-polypropylene-fibers-to-the-quantitation-of-igg-in-complex-matrices
#17
Hung K Trang, R Kenneth Marcus
Polypropylene (PP) capillary-channeled polymer (C-CP) fibers loaded with recombinant Staphyloccocus aureus protein A (rSPA) were used as an affinity chromatography stationary phase for the quantitation of immunoglobulin G (IgG) in complex biological matrices. Optimization of the chromatographic method regarding mobile phase components and load/elution conditions was performed. The six-minute analysis, including a load step with 12mM phosphate at pH 7.4, an elution step with 0.025% phosphoric acid and a re-equilibration step, was employed for quantitation of IgG1 from 0...
August 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28466356/recurrent-otorrhea-in-chronic-suppurative-otitis-media-is-biofilm-the-missing-link
#18
Ramon Gordon Jensen, Helle Krogh Johansen, Thomas Bjarnsholt, Steffen Robert Eickhardt-Sørensen, Preben Homøe
Dispersal of bacteria from a biofilm in the middle ear, serving as a bacterial reservoir, could explain the recurrent and chronic nature of chronic suppurative otitis media (CSOM). The objective of this study is to investigate if the same strains of bacteria could be detected in repeated episodes of otorrhea in CSOM. In a prospective case series at a primary healthcare clinic in Nuuk, Greenland, patients with more than 14 days of otorrhea were included consecutively. Samples for culturing and biofilm analysis were taken at enrollment and at any subsequent episode with otorrhea...
July 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28459996/the-role-of-p38-mapk-jnk-and-erk-in-antibacterial-responses-of-chilo-suppressalis-lepidoptera-crambidae
#19
Lin Qiu, Boyao Zhang, Lang Liu, Xiaoping Wang, Chaoliang Lei, Yongjun Lin, Jing Zhao, Weihua Ma
The mitogen-activated protein kinases (MAPKs) are conserved signal transduction pathways and broadly responsible for bacterial infection from yeast to mammals, and virus, fungi, and bacteria, specifically Bacillus thuringiensis, to insects. But little is known about the MAPK pathways in antibacterial responses in Chilo suppressalis (Walker), an important lepidopteran pest of rice. In this study, we used the bacteria of Bacillus thuringiensis, Escherichia coli, and Staphyloccocus aureus to infect C. suppressalis larvae, and the responses of MAPK pathways were analyzed...
August 1, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28379505/the-rna-targetome-of-staphylococcus-aureus-non-coding-rna-rsaa-impact-on-cell-surface-properties-and-defense-mechanisms
#20
Arnaud Tomasini, Karen Moreau, Johana Chicher, Thomas Geissmann, François Vandenesch, Pascale Romby, Stefano Marzi, Isabelle Caldelari
The virulon of Staphyloccocus aureus is controlled by intricate connections between transcriptional and post-transcriptional regulators including proteins and small non-coding RNAs (sRNAs). Many of the sRNAs regulate gene expression through base-pairings with mRNAs. However, characterization of the direct sRNA targets in Gram-positive bacteria remained a difficult challenge. Here, we have applied and adapted the MS2-affinity purification approach coupled to RNA sequencing (MAPS) to determine the targetome of RsaA sRNA of S...
June 20, 2017: Nucleic Acids Research
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