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Staphyloccocus aureus

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https://www.readbyqxmd.com/read/28135800/dual-mode-of-action-for-plusbacin-a3-in-staphylococcus-aureus
#1
Robert D O'Connor, Manmilan Singh, James Chang, Sung Joon Kim, Michael VanNieuwenhze, Jacob Schaefer
We have used C{F}, N{F}, and N{P} rotational-echo double resonance NMR to determine the location and conformation of (19)F and (15)N double-labeled plusbacin A3 and of double-labeled deslipo-plusbacin A3, each bound to the cell walls of whole cells of Staphyloccocus aureus grown in media containing [1-(13)C]glycine. The (31)P is primarily in wall teichoic acid. Approximately 25% of plusbacin headgroups (the cyclic depsipeptide backbone) are in a closed conformation (N-F separation of 6 Å), while 75% are in a more open conformation (N-F separation of 12 Å)...
February 13, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28117265/the-extracellular-adherence-protein-eap-of-staphylococcus-aureus-acts-as-a-proliferation-and-migration-repressing-factor-that-alters-the-cell-morphology-of-keratinocytes
#2
Janina Eisenbeis, Henrik Peisker, Christian S Backes, Stephanie Bur, Sebastian Hölters, Nicolas Thewes, Markus Greiner, Christian Junker, Eva C Schwarz, Markus Hoth, Kerstin Junker, Klaus T Preissner, Karin Jacobs, Mathias Herrmann, Markus Bischoff
Staphyloccocus aureus is a major human pathogen and a common cause for superficial and deep seated wound infections. The pathogen is equipped with a large arsenal of virulence factors, which facilitate attachment to various eukaryotic cell structures and modulate the host immune response. One of these factors is the extracellular adherence protein Eap, a member of the "secretable expanded repertoire adhesive molecules" (SERAM) protein family that possesses adhesive and immune modulatory properties. The secreted protein was previously shown to impair wound healing by interfering with host defense and neovascularization...
January 18, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/28045495/bacterial-networks-on-hydrophobic-micropillars
#3
Zeinab Jahed, Hamed Shahsavan, Mohit S Verma, Jacob L Rogowski, Brandon B Seo, Boxin Zhao, Ting Y Tsui, Frank X Gu, Mohammad R K Mofrad
Bacteria have evolved as intelligent microorganisms that can colonize and form highly structured and cooperative multicellular communities with sophisticated singular and collective behaviors. The initial stages of colony formation and intercellular communication are particularly important to understand and depend highly on the spatial organization of cells. Controlling the distribution and growth of bacterial cells at the nanoscale is, therefore, of great interest in understanding the mechanisms of cell-cell communication at the initial stages of colony formation...
January 9, 2017: ACS Nano
https://www.readbyqxmd.com/read/27803487/improvement-of-predictivity-of-teicoplanin-serum-trough-concentrations-at-steady-state-calculated-by-vancomycin-pharmacokinetic-parameter
#4
Ryo Kobayashi, Shinya Otomo, Yusuke Shiba, Keiichi Ebinuma, Toshiaki Sudoh
 According to a recent study and meta-analysis, trough levels of >10 μg/mL teicoplanin (TEIC) may be acceptable for the treatment of uncomplicated infection, but no method of TEIC personalized medicine has been established. Vancomycin (VCM) and TEIC are glycopeptide antibiotic agents effective against methicillin-resistance Staphyloccocus aureus. This study aimed to establish TEIC personalized medicine at a steady state calculated by VCM pharmacokinetic parameters. Bayesian forecasting and population mean methods were employed to estimate individual total VCM clearance (CL) using existing population pharmacokinetics (PPK) parameter, and the differences between the CL calculated by these two methods were defined as ΔCL...
2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/27731830/detection-of-antibiotic-residues-in-poultry-meat
#5
Abdul Sajid, Natasha Kashif, Nasira Kifayat, Shabeer Ahmad
The antibiotic residues in poultry meat can pose certain hazards to human health among them are sensitivity to antibiotics, allergic reactions, mutation in cells, imbalance of intestinal micro biota and bacterial resistance to antibiotics. The purpose of the present paper was to detect antibiotic residue in poultry meat. During the present study a total of 80 poultry kidney and liver samples were collected and tested for detection of different antibiotic residues at different pH levels Eschericha coli at pH 6, 7 and Staphyloccocus aureus at pH 8 & 9...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27552087/host-guest-self-assembly-toward-reversible-thermoresponsive-switching-for-bacteria-killing-and-detachment
#6
Zhen-Qiang Shi, Yu-Ting Cai, Jie Deng, Wei-Feng Zhao, Chang-Sheng Zhao
A facile method to construct reversible thermoresponsive switching for bacteria killing and detachment was currently developed by host-guest self-assembly of β-cyclodextrin (β-CD) and adamantane (Ad). Ad-terminated poly(N-isopropylacrylamide) (Ad-PNIPAM) and Ad-terminated poly[2-(methacryloyloxy)ethyl]trimethylammonium chloride (Ad-PMT) were synthesized via atom transfer radical polymerization, and then assembled onto the surface of β-CD grafted silicon wafer (SW-CD) by simply immersing SW-CD into a mixed solution of Ad-PNIPAM and Ad-PMT, thus forming a thermoresponsive surface (SW-PNIPAM/PMT)...
September 14, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27530662/coatx-ii-a-new-dimeric-lys49-phospholipase-a2-from-crotalus-oreganus-abyssus-snake-venom-with-bactericidal-potential-insights-into-its-structure-and-biological-roles
#7
J R Almeida, M Lancellotti, A M Soares, L A Calderon, D Ramírez, W González, S Marangoni, S L Da Silva
Snake venoms are rich and intriguing sources of biologically-active molecules that act on target cells, modulating a diversity of physiological functions and presenting promising pharmacological applications. Lys49 phospholipase A2 is one of the multifunctional proteins present in these complex secretions and, although catalytically inactive, has a variety of biological activities, including cytotoxic, antibacterial, inflammatory, antifungal activities. Herein, a Lys49 phospholipase A2, denominated CoaTx-II from Crotalus oreganus abyssus, was purified and structurally and pharmacologically characterized...
September 15, 2016: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/27492507/long-term-effects-of-azithromycin-in-patients-with-cystic-fibrosis
#8
Clémentine Samson, Aline Tamalet, Hoang Vu Thien, Jessica Taytard, Caroline Perisson, Nadia Nathan, Annick Clement, Pierre-Yves Boelle, Harriet Corvol
BACKGROUND: Low-dose azithromycin has beneficial effects on severity of the lung disease in cystic fibrosis (CF) patients for a period of 6-12 months after initiation of the treatment. Although its impact in the longer term is uncertain, this treatment is frequently used chronically. The aim of this retrospective study was to investigate the effects of low-dose azithromycin treatment on the progression of CF lung disease in patients treated for more than 12 months. METHODS: All of the CF patients followed in our pediatric center and who had been on low-dose azithromycin for more than 12 sequential months were included...
August 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27457409/multicomponent-petasis-borono-mannich-preparation-of-alkylaminophenols-and-antimicrobial-activity-studies
#9
Íris Neto, Joana Andrade, A S Fernandes, Catarina Pinto Reis, Jagadish K Salunke, Arri Priimagi, Nuno R Candeias, Patrícia Rijo
In this work we report the antibacterial activity of alkylaminophenols. A series of such compounds was prepared by a multicomponent Petasis-borono Mannich reaction starting from salicylaldehyde and its derivatives. The obtained compounds were tested against a large panel of microorganisms, Gram-positive and Gram-negative bacteria, and a yeast. Among the several tertiary amine derivatives tested, indoline-derived aminophenols containing a nitro group at the para-phenol position showed considerable activity against bacteria tested with minimal inhibitory concentrations as low as 1...
September 20, 2016: ChemMedChem
https://www.readbyqxmd.com/read/27424376/methicillin-resistant-staphyloccocus-aureus-intracranial-epidural-abscess-with-osteomyelitis-during-pregnancy-a-case-report
#10
Vaya W Tanamai, Brandon-Luke L Seagle, Guoyang Luo
BACKGROUND: The incidence of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infection is increasing, and 0.5-4% of pregnant women are colonized. CASE: A 30-year-old pregnant woman at term presented with intractable headache 1 week after incision and drainage of a MRSA-positive axillary abscess. Imaging demonstrated a right-sided epidural abscess with midline shift and myositis of the overlying temporalis muscle. She underwent cesarean delivery followed by craniectomy of osteomyelitic bone and evacuation of the epidural abscess...
May 2016: Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/27315549/increased-mortality-rates-associated-with-staphylococcus-aureus-and-influenza-co-infection-maryland-and-iowa-usa-1
#11
Jennifer S McDanel, Eli N Perencevich, Jeremy Storm, Daniel J Diekema, Loreen Herwaldt, J Kristie Johnson, Patricia L Winokur, Marin L Schweizer
We retrospectively analyzed data for 195 respiratory infection patients who had positive Staphyloccocus aureus cultures and who were hospitalized in 2 hospitals in Iowa and Maryland, USA, during 2003-2009. Odds for death for patients who also had influenza-positive test results were >4 times higher than for those who had negative influenza test results.
July 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27279413/two-endoplasmic-reticulum-proteins-calnexin-and-calreticulin-are-involved-in-innate-immunity-in-chinese-mitten-crab-eriocheir-sinensis
#12
Ying Huang, Kaimin Hui, Min Jin, Shaowu Yin, Wen Wang, Qian Ren
Calnexin (Cnx) and calreticulin (Crt), which are important chaperones in the endoplasmic reticulum (ER), participate in the folding and quality control of client proteins. Cnx and Crt identified from Chinese mitten crab (Eriocheir sinensis) are designated as EsCnx and EsCrt, respectively. EsCnx and EsCrt are expressed in the hemocyte, hepatopancrea, gill, and intestine at the mRNA and protein level. Immunofluorescence analysis indicated that EsCnx and EsCRT are located in the ER. Moreover, the mRNA and protein expression levels of EsCnx and EsCrt were altered by challenge with lipopolysaccharides (LPS), peptidoglycans (PGN), Staphyloccocus aureus, and Vibrio parahaemolyticus...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27242749/comparative-resistance-of-bacterial-foodborne-pathogens-to-non-thermal-technologies-for-food-preservation
#13
REVIEW
Guillermo Cebrián, Pilar Mañas, Santiago Condón
In this paper the resistance of bacterial foodborne pathogens to manosonication (MS), pulsed electric fields (PEFs), high hydrostatic pressure (HHP), and UV-light (UV) is reviewed and compared. The influence of different factors on the resistance of bacterial foodborne pathogens to these technologies is also compared and discussed. Only results obtained under harmonized experimental conditions have been considered. This has allowed us to establish meaningful comparisons and draw significant conclusions. Among the six microorganisms here considered, Staphyloccocus aureus is the most resistant foodborne pathogen to MS and HHP and Listeria monocytogenes to UV...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27107714/strain-level-staphylococcus-differentiation-by-ceo2-metal-oxide-laser-ionization-mass-spectrometry-fatty-acid-profiling
#14
Nicholas R Saichek, Christopher R Cox, Seungki Kim, Peter B Harrington, Nicholas R Stambach, Kent J Voorhees
BACKGROUND: The Staphylococcus genus is composed of 44 species, with S. aureus being the most pathogenic. Isolates of S. aureus are generally susceptible to β-lactam antibiotics, but extensive use of this class of drugs has led to increasing emergence of resistant strains. Increased occurrence of coagulase-negative staphylococci as well as S. aureus infections, some with resistance to multiple classes of antibiotics, has driven the necessity for innovative options for treatment and infection control...
April 23, 2016: BMC Microbiology
https://www.readbyqxmd.com/read/26993663/function-of-gc1qr-in-innate-immunity-of-chinese-mitten-crab-eriocheir-sinensis
#15
Ying Huang, Wen Wang, Qian Ren
gC1qR is identified as the globular "head" binding protein of the C1q protein and performs an important function in innate immunity. A EsgC1qR gene was identified from the hepatopancreas of Eriocheir sinensis. EsgC1qR encodes a protein with 275 amino acids. Phylogenetic analysis showed that, together with crustaceans gC1qRs, EsgC1qR belongs to one group. EsgC1qR mRNA was detected in hemocytes, intestine, hepatopancreas, gills, eyestalk, heart, muscle, and nerve. The expression of the EsgC1qR transcript in the hepatopancreas could be regulated by lipopolysaccharides (LPS), peptidoglycans (PGN), Staphyloccocus aureus, or Vibrio parahaemolyticus...
August 2016: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/26919444/evaluation-of-loading-characteristics-and-igg-binding-performance-of-staphylococcal-protein-a-on-polypropylene-capillary-channeled-polymer-fibers
#16
Hung K Trang, Abby J Schadock-Hewitt, Liuwei Jiang, R Kenneth Marcus
The loading characteristics of recombinant Staphyloccocus aureus protein A (rSPA) on polypropylene (PP) capillary-channeled polymer (C-CP) fibers were investigated through breakthrough curves and frontal analysis. The dynamic adsorption data was fit to various isotherm models to assess the possible mode of rSPA-PP fiber adsorption. Among them, the Langmuir-linear model fit the experimental data best, suggesting a two-stage mechanism of adsorption. The first stage involves the formation of a monolayer coverage, which follows the Langmuir isotherm...
March 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/26774252/synthesis-antimicrobial-evaluation-and-molecular-modeling-of-5-hydroxyisoquinolinium-salt-series-the-effect-of-the-hydroxyl-moiety
#17
Ondrej Soukup, Rafael Dolezal, David Malinak, Jan Marek, Sarka Salajkova, Marketa Pasdiorova, Jan Honegr, Jan Korabecny, Petr Nachtigal, Florian Nachon, Daniel Jun, Kamil Kuca
In the present paper, we describe the synthesis of a new group of 5-hydroxyisoquinolinium salts with different lengths of alkyl side-chain (C10-C18), and their chromatographic analysis and biological assay for in vitro activity against bacterial and fungal strains. We compare the lipophilicity and efficacy of hydroxylated isoquinolinium salts with the previously published (non-hydroxylated) isoquinolinium salts from the point of view of antibacterial and antifungal versatility and cytotoxic safety. Compound 11 (C18) had to be excluded from the testing due to its low solubility...
February 15, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/26713295/septic-arthritis-in-the-temporomandibular-joint
#18
Hassan Mahdi Al-Khalisy, Ivan Nikiforov, Qurat Mansoora, John Goldman, Pramil Cheriyath
UNLABELLED: Septic arthritis of the temporomandibular joint (TMJ) is a rare event that has only been reported a few dozen times worldwide. This case is remarkable for septic arthritis of the TMJ joint in an otherwise healthy male. CASE REPORT: A 24-year-old male presented to the emergency department with periauricular swelling, erythema, fever, myalgia's and generalized joint pain. He had previously sought medical attention and was placed on ciprofloxacin. However, he developed facial swelling and a rash and had to discontinue the antibiotic...
October 2015: North American Journal of Medical Sciences
https://www.readbyqxmd.com/read/26479210/a-new-acid-oxidizing-solution-assessment-of-its-role-on-methicillin-resistant-staphylococcus-aureus-mrsa-biofilm-morphological-changes
#19
COMPARATIVE STUDY
Noemi D'Atanasio, Alessandra Capezzone de Joannon, Giorgina Mangano, Marisa Meloni, Nadia Giarratana, Claudio Milanese, Serena Tongiani
OBJECTIVE: Biofilms represent a key challenge in the treatment of chronic wounds, as they are among the main reasons for delays in chronic wound healing. This in vitro study was aimed at evaluating the activity of a new acid-oxidizing solution (AOS) on biofilm formation. Acid-oxidizing solution contains free chlorine species with stabilized hypochlorous acid in high concentration (> 95%) and is characterized by acidic (pH less than 3) and super-oxidizing (Redox greater than 1000mV) features...
October 2015: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/26457513/crystallization-and-initial-crystallographic-analysis-of-covalent-dna-cleavage-complexes-of-staphyloccocus-aureus-dna-gyrase-with-qpt-1-moxifloxacin-and-etoposide
#20
Velupillai Srikannathasan, Alexandre Wohlkonig, Anthony Shillings, Onkar Singh, Pan F Chan, Jianzhong Huang, Michael N Gwynn, Andrew P Fosberry, Paul Homes, Martin Hibbs, Andrew J Theobald, Claus Spitzfaden, Benjamin D Bax
Fluoroquinolone drugs such as moxifloxacin kill bacteria by stabilizing the normally transient double-stranded DNA breaks created by bacterial type IIA topoisomerases. Previous crystal structures of Staphylococcus aureus DNA gyrase with asymmetric DNAs have had static disorder (with the DNA duplex observed in two orientations related by the pseudo-twofold axis of the complex). Here, 20-base-pair DNA homoduplexes were used to obtain crystals of covalent DNA-cleavage complexes of S. aureus DNA gyrase. Crystals with QPT-1, moxifloxacin or etoposide diffracted to between 2...
October 2015: Acta Crystallographica. Section F, Structural Biology Communications
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