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Bordetella bronchiseptica

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https://www.readbyqxmd.com/read/28906022/identification-and-characterization-of-a-brilliant-yellow-pigment-produced-by-bordetella-pertussis
#1
Keita Odanaka, Masato Iwatsuki, Tomomitsu Satho, Mineo Watanabe
Culture supernatant of Bordetella pertussis has a brilliant yellow color; however, the structure and biological role of the pigment have not been investigated. We extracted the brilliant yellow-colored fraction from the culture supernatant of B. pertussis and analyzed it by HPLC. UV-visible spectral analysis and mass spectrometry identified the brilliant yellow pigment as riboflavin. Riboflavin production was high in lag and early log phases and riboflavin enhanced the growth of B. pertussis in low-density cultures...
September 14, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28892012/bordetella-adenylate-cyclase-hemolysin-toxins
#2
REVIEW
Nicole Guiso
Adenylate cyclase-hemolysin toxin is secreted and produced by three classical species of the genus Bordetella: Bordetella pertussis, B. parapertussis and B. bronchiseptica. This toxin has several properties such as: (i) adenylate cyclase activity, enhanced after interaction with the eukaryotic protein, calmodulin; (ii) a pore-forming activity; (iii) an invasive activity. It plays an important role in the pathogenesis of these Bordetella species responsible for whooping cough in humans or persistent respiratory infections in mammals, by modulating host immune responses...
September 11, 2017: Toxins
https://www.readbyqxmd.com/read/28875161/crystal-structures-of-a-zip-zinc-transporter-reveal-a-binuclear-metal-center-in-the-transport-pathway
#3
Tuo Zhang, Jian Liu, Matthias Fellner, Chi Zhang, Dexin Sui, Jian Hu
Zrt/Irt-like proteins (ZIPs) play fundamental roles in metal metabolism/homeostasis and are broadly involved in numerous physiological and pathological processes. The lack of high-resolution structure of the ZIPs hinders understanding of the metal transport mechanism. We report two crystal structures of a prokaryotic ZIP in lipidic cubic phase with bound metal substrates (Cd(2+) at 2.7 Å and Zn(2+) at 2.4 Å). The structures revealed a novel 3+2+3TM architecture and an inward-open conformation occluded at the extracellular side...
August 2017: Science Advances
https://www.readbyqxmd.com/read/28865149/bordetella-bronchiseptica-bloodstream-infection-in-a-renal-transplant-patient
#4
Harry R Powers, Kairav Shah
Bordetella bronchiseptica is a gram-negative coccobacillus that infects animals, but rarely affects humans. B. bronchiseptica has been reported to cause disease in immunocompromised hosts. We present a case of a 61-year-old man with a renal transplant who developed B. bronchiseptica bacteremia likely as a result of close contact between dogs and his skin cancer biopsy sites. The patient was successfully treated with 2 weeks of oral levofloxacin. This case alerts physicians to B. bronchiseptica as a cause of bacteremia in solid organ transplant patients with exposure to animals...
September 2, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28827216/activation-of-bvg-repressed-genes-in-bordetella-pertussis-by-risa-requires-cross-talk-from-a-non-co-operonic-histidine-kinase-risk
#5
Qing Chen, Victoria Ng, Jason M Warfel, Tod J Merkel, Scott Stibitz
The two-component response regulator RisA, encoded by BP3554 in the Bordetella pertussis Tohama I genomic sequence, is a known activator of vrgs, a set of genes whose expression is increased under the same environmental conditions (known as modulation) that result in repression of the bvgAS virulence regulon. Here we demonstrate that RisA is phosphorylated in vivo and that RisA phosphorylation is required for activation of vrgs. An adjacent histidine kinase gene, risS, is truncated by frameshift mutation in B...
August 21, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28761185/comparative-efficacy-of-intranasal-and-injectable-vaccines-in-stimulating-bordetella-bronchiseptica-reactive-anamnestic-antibody-responses-in-household-dogs
#6
John A Ellis, Sheryl P Gow, Lindsey B Lee, Stacey Lacoste, Eileen C Ball
In order to determine the comparative efficacy of injectable and intranasal vaccines to stimulate Bordetella bronchiseptica (Bb)-reactive anamnestic antibodies, a trial was conducted using 144 adult household dogs of various breeds and ages, which had been previously administered intranasal Bb vaccine approximately 12 months before enrollment. Dogs were randomized into 2 groups and blood, nasal swabs, and pharyngeal swabs were collected prior to the administration of single component Bb vaccines intranasally or parenterally...
August 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28752940/protective-effects-of-in-vivo-expressed-autotransporters-against-bordetella-pertussis-infection
#7
Koichiro Suzuki, Naoaki Shinzawa, Keisuke Ishigaki, Keiji Nakamura, Hiroyuki Abe, Aya Fukui-Miyazaki, Kazuyoshi Ikuta, Yasuhiko Horiguchi
Bordetella pertussis causes whooping cough, a severe and prolonged respiratory disease that results in high morbidity and mortality rates, particularly in developing countries. The number of whooping cough cases is increasing in many countries despite high vaccine coverage. Causes for the re-emergence of the disease include the limited duration of protection conferred by the acellular pertussis vaccines (aP) and pathogenic adaptations that involve antigenic divergence from vaccine strains. Therefore, current vaccines need to be improved...
July 28, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28749292/molecular-detection-of-infectious-pathogens-of-the-upper-respiratory-tract-in-captive-nondomestic-felids
#8
Valéria M Lara, Julia C Benassi, Shayne P Bisetto, Trícia M de Oliveira, Helena L Ferreira, João P Araújo Júnior, Adriano B Carregaro
Upper respiratory tract disease is a complex infectious disease process with multiple pathogens involved. Identification of infectious agents in wild animals is of great importance for wildlife conservation. The aim of this study was to evaluate the molecular detection of feline herpesvirus type 1, feline calicivirus (FCV), Bordetella bronchiseptica , Chlamydophila felis , and Mycoplasma felis using ocular and nasal swabs in three species of captive nondomestic felids. Mycoplasma felis was detected in two ocular samples of Puma concolor and in one nasal sample of one Panthera onca ...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28640910/correction-btea-secreted-from-the-bordetella-bronchiseptica-type-iii-secetion-system-induces-necrosis-through-an-actin-cytoskeleton-signaling-pathway-and-inhibits-phagocytosis-by-macrophages
#9
Asaomi Kuwae, Fumitaka Momose, Kanna Nagamatsu, Yasuharu Suyama, Akio Abe
[This corrects the article DOI: 10.1371/journal.pone.0148387.].
2017: PloS One
https://www.readbyqxmd.com/read/28559403/the-bordetella-bps-polysaccharide-is-required-for-biofilm-formation-and-enhances-survival-in-the-lower-respiratory-tract-of-swine
#10
Tracy L Nicholson, Susan L Brockmeier, Neelima Sukumar, Alexandra E Paharik, Jessica L Lister, Alexander R Horswill, Marcus E Kehrli, Crystal L Loving, Sarah M Shore, Rajendar Deora
Bordetella bronchiseptica is pervasive in swine populations and plays multiple roles in respiratory disease. Additionally, B. bronchiseptica is capable of establishing long-term or chronic infections in swine. Bacterial biofilms are increasingly recognized as important contributors to chronic bacterial infections. Recently the polysaccharide locus bpsABCD has been demonstrated to serve a critical role in the development of mature biofilms formed by the sequenced laboratory strain of B. bronchiseptica We hypothesized that swine isolates would also have the ability to form mature biofilms and the bpsABCD locus would serve a key role in this process...
August 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28500733/bordetella-effector-bopn-is-translocated-into-host-cells-via-its-n-terminal-residues
#11
Akio Abe, Ryutaro Nishimura, Asaomi Kuwae
Bordetella bronchiseptica infects a wide variety of mammals, and the type III secretion system (T3SS) is involved in the long-term colonization of Bordetella in the trachea and lung. The T3SS translocates virulence factors (commonly referred to as effectors) into host cells, leading to alteration of the host physiological function. The Bordetella effectors BopN and BteA are known to have roles in the up-regulation of IL-10 and the cytotoxicity, respectively. Nevertheless, the mechanism by which BopN is translocated into host cells has not been examined in sufficient detail...
May 13, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28463965/ancient-bacteria-amoeba-relationships-and-pathogenic-animal-bacteria
#12
Joan E Strassmann, Longfei Shu
Long before bacteria infected humans, they infected amoebas, which remain a potentially important reservoir for human disease. Diverse soil amoebas including Dictyostelium and Acanthamoeba can host intracellular bacteria. Though the internal environment of free-living amoebas is similar in many ways to that of mammalian macrophages, they differ in a number of important ways, including temperature. A new study in PLOS Biology by Taylor-Mulneix et al. demonstrates that Bordetella bronchiseptica has two different gene suites that are activated depending on whether the bacterium finds itself in a hot mammalian or cool amoeba host environment...
May 2017: PLoS Biology
https://www.readbyqxmd.com/read/28403204/improving-specificity-of-bordetella-pertussis-detection-using-a-four-target-real-time-pcr
#13
Helena Martini, Liselot Detemmerman, Oriane Soetens, Erlangga Yusuf, Denis Piérard
The incidence of whooping cough, a contagious respiratory disease caused by Bordetella pertussis, is on the rise despite existing vaccination programmes. Similar, though usually milder, respiratory symptoms may be caused by other members of the Bordetella genus: B. parapertussis, B. holmesii, and B. bronchiseptica. Pertussis diagnosis is mostly done using PCR, but the use of multiple targets is necessary in order to differentiate the different Bordetella spp. with sufficient sensitivity and specificity. In this study we evaluate a multiplex PCR assay for the differentiation of B...
2017: PloS One
https://www.readbyqxmd.com/read/28403138/bordetella-bronchiseptica-exploits-the-complex-life-cycle-of-dictyostelium-discoideum-as-an-amplifying-transmission-vector
#14
Dawn L Taylor-Mulneix, Liron Bendor, Bodo Linz, Israel Rivera, Valerie E Ryman, Kalyan K Dewan, Shannon M Wagner, Emily F Wilson, Lindsay J Hilburger, Laura E Cuff, Christopher M West, Eric T Harvill
Multiple lines of evidence suggest that Bordetella species have a significant life stage outside of the mammalian respiratory tract that has yet to be defined. The Bordetella virulence gene (BvgAS) two-component system, a paradigm for a global virulence regulon, controls the expression of many "virulence factors" expressed in the Bvg positive (Bvg+) phase that are necessary for successful respiratory tract infection. A similarly large set of highly conserved genes are expressed under Bvg negative (Bvg-) phase growth conditions; however, these appear to be primarily expressed outside of the host and are thus hypothesized to be important in an undefined extrahost reservoir...
April 2017: PLoS Biology
https://www.readbyqxmd.com/read/28348142/survey-of-susceptibility-to-marbofloxacin-in-bacteria-isolated-from-diseased-pigs-in-europe
#15
F El Garch, S Kroemer, D Galland, I Morrissey, F Woehrle
A monitoring programme of marbofloxacin susceptibility of bacteria from Europe causing respiratory tract infection and meningitis in pigs has been active since 1994 and 2002, respectively. Monitoring digestive, metritis and urinary tract infection (UTI) in pigs has been active since 2005 and susceptibility results until 2013 are presented. Minimum inhibitory concentration (MIC) was determined by broth microdilution. For MIC interpretation, Vétoquinol-evaluated breakpoints were applied. For digestive pathogens, Escherichia coli and Salmonella species (1717 and 300 isolates, respectively) exhibited 7...
June 17, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28348085/the-extent-of-the-temperature-induced-membrane-remodeling-in-two-closely-related-bordetella-species-reflects-their-adaptation-to-diverse-environmental-niches
#16
Gabriela Seydlova, Jana Beranova, Ilona Bibova, Ana Dienstbier, Jakub Drzmisek, Jiri Masin, Radovan Fiser, Ivo Konopasek, Branislav Vecerek
Changes in environmental temperature represent one of the major stresses faced by microorganisms as they affect the function of the cytoplasmic membrane. In this study, we have analyzed the thermal adaptation in two closely related respiratory pathogens Bordetella pertussis and Bordetella bronchiseptica Although B. pertussis represents a pathogen strictly adapted to the human body temperature, B. bronchiseptica causes infection in a broad range of animals and survives also outside of the host. We applied GC-MS to determine the fatty acids of both Bordetella species grown at different temperatures and analyzed the membrane fluidity by fluorescence anisotropy measurement...
May 12, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28289415/pasteurella-multocida-toxin-triggers-rankl-independent-osteoclastogenesis
#17
Sushmita Chakraborty, Bianca Kloos, Ulrike Harre, Georg Schett, Katharina F Kubatzky
Bone remodeling is a continuous process to retain the structural integrity and function of the skeleton. A tight coupling is maintained between osteoclast-mediated resorption of old or damaged bones and osteoblast-mediated formation of new bones for bone homeostasis. While osteoblasts differentiate from mesenchymal stem cells, osteoclasts are hematopoietic in origin and derived from myeloid precursor cells. Osteoclast differentiation is driven by two cytokines, cytokine receptor activator of NF-κB ligand (RANKL), and macrophage colony-stimulating factor...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28177609/fine-epitope-mapping-of-two-antibodies-neutralizing-the-bordetella-adenylate-cyclase-toxin
#18
Xianzhe Wang, James A Stapleton, Justin R Klesmith, Erik L Hewlett, Timothy A Whitehead, Jennifer A Maynard
Adenylate cyclase toxin (ACT) is an important Bordetella pertussis virulence factor that is not included in current acellular pertussis vaccines. We previously demonstrated that immunization with the repeat-in-toxin (RTX) domain of ACT elicits neutralizing antibodies in mice and discovered the first two antibodies to neutralize ACT activities by occluding the receptor-binding site. Here, we fully characterize these antibodies and their epitopes. Both antibodies bind ACT with low nanomolar affinity and cross-react with ACT homologues produced by B...
March 7, 2017: Biochemistry
https://www.readbyqxmd.com/read/28174558/environmental-origin-of-the-genus-bordetella
#19
Illiassou Hamidou Soumana, Bodo Linz, Eric T Harvill
Members of the genus Bordetella include human and animal pathogens that cause a variety of respiratory infections, including whooping cough in humans. Despite the long known ability to switch between a within-animal and an extra-host lifestyle under laboratory growth conditions, no extra-host niches of pathogenic Bordetella species have been defined. To better understand the distribution of Bordetella species in the environment, we probed the NCBI nucleotide database with the 16S ribosomal RNA (16S rRNA) gene sequences from pathogenic Bordetella species...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28167784/bordetella-plrsr-regulatory-system-controls-bvgas-activity-and-virulence-in-the-lower-respiratory-tract
#20
M Ashley Bone, Aaron J Wilk, Andrew I Perault, Sara A Marlatt, Erich V Scheller, Rebecca Anthouard, Qing Chen, Scott Stibitz, Peggy A Cotter, Steven M Julio
Bacterial pathogens coordinate virulence using two-component regulatory systems (TCS). The Bordetella virulence gene (BvgAS) phosphorelay-type TCS controls expression of all known protein virulence factor-encoding genes and is considered the "master virulence regulator" in Bordetella pertussis, the causal agent of pertussis, and related organisms, including the broad host range pathogen Bordetella bronchiseptica We recently discovered an additional sensor kinase, PlrS [for persistence in the lower respiratory tract (LRT) sensor], which is required for B...
February 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
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