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https://www.readbyqxmd.com/read/28335253/soft-interaction-in-liposome-nanocarriers-for-therapeutic-drug-delivery
#1
REVIEW
Domenico Lombardo, Pietro Calandra, Davide Barreca, Salvatore Magazù, Mikhail A Kiselev
The development of smart nanocarriers for the delivery of therapeutic drugs has experienced considerable expansion in recent decades, with the development of new medicines devoted to cancer treatment. In this respect a wide range of strategies can be developed by employing liposome nanocarriers with desired physico-chemical properties that, by exploiting a combination of a number of suitable soft interactions, can facilitate the transit through the biological barriers from the point of administration up to the site of drug action...
June 25, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334019/cell-survival-and-differentiation-with-nanocrystalline-glass-like-carbon-using-substantia-nigra-dopaminergic-cells-derived-from-transgenic-mouse-embryos
#2
Noela Rodriguez-Losada, Pablo Romero, Guillermo Estivill-Torrús, Roberto Guzmán de Villoria, Jose A Aguirre
Regenerative medicine requires, in many cases, physical supports to facilitate appropriate cellular architecture, cell polarization and the improvement of the correct differentiation processes of embryonic stem cells, induced pluripotent cells or adult cells. Because the interest in carbon nanomaterials has grown within the last decade in light of a wide variety of applications, the aim of this study was to test and evaluate the suitability and cytocompatibility of a particular nanometer-thin nanocrystalline glass-like carbon film (NGLC) composed of curved graphene flakes joined by an amorphous carbon matrix...
2017: PloS One
https://www.readbyqxmd.com/read/28332447/the-effect-of-native-silk-fibroin-powder-on-the-physical-properties-and-biocompatibility-of-biomedical-polyurethane-membrane
#3
Yan Zhuang, Qian Zhang, Jinqi Feng, Na Wang, Weilin Xu, Hongjun Yang
Naturally derived fibers such as silk fibroin can potentially enhance the biocompatibility of currently used biomaterials. This study investigated the physical properties of native silk fibroin powder and its effect on the biocompatibility of biomedical polyurethane. Native silk fibroin powder with an average diameter of 3 µm was prepared on a purpose-built machine. A simple method of phase inversion was used to produce biomedical polyurethane/native silk fibroin powder hybrid membranes at different blend ratios by immersing a biomedical polyurethane/native silk fibroin powder solution in deionized water at room temperature...
April 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28328976/high-school-science-fair-and-research-integrity
#4
Frederick Grinnell, Simon Dalley, Karen Shepherd, Joan Reisch
Research misconduct has become an important matter of concern in the scientific community. The extent to which such behavior occurs early in science education has received little attention. In the current study, using the web-based data collection program REDCap, we obtained responses to an anonymous and voluntary survey about science fair from 65 high school students who recently competed in the Dallas Regional Science and Engineering Fair and from 237 STEM-track, post-high school students (undergraduates, 1st year medical students, and 1st year biomedical graduate students) doing research at UT Southwestern Medical Center...
2017: PloS One
https://www.readbyqxmd.com/read/28328495/the-modern-cochlear-implant-a-triumph-of-biomedical-engineering-and-the-first-substantial-restoration-of-human-sense-using-a-medical-intervention
#5
Blake S Wilson
Even as recently as the mid-1980s, many experts in otology and auditory science thought that restoration of useful hearing with crude and pervasive electrical stimulation of the cochlea was a fool's dream. The esteemed Prof. Rainer Klinke from Frankfurt (Figure 1) was among the chorus of critics, asserting in 1978 that "from a physiological point of view, cochlear implants will not work." Many others made similar categorical statements.
March 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28328201/double-fueled-janus-swimmers-with-magnetotactic-behaviour
#6
Philipp Sebastian Schattling, Miguel Alexandre Ramos-Docampo, Veronica Salgueiriño, Brigitte Städler
Self-propelled particles attract a great deal of attention due to the auspicious range of application nanobots can be used for. In a biomedical context, self-propelled swimmers hold promise to autonomously navigate to a desired location in an attempt to counteract cell/tissue defects either by releasing drugs or performing surgical tasks. The vast majority of prior reports deal with single engine assemblies, often utilizing fuel molecules which are considered as highly cytotoxic. Herein, we introduce two engines: 1) a motor which couples enzymes i...
March 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/28325007/building-a-more-diverse-biomedical-engineering-workforce-biomedical-engineering-at-the-university-of-the-district-of-columbia-a-historically-black-college-university
#7
Lara A Thompson, A Segun Adebayo, Nian Zhang, Sasan Haghani, Kathleen Dowell, Devdas Shetty
Biomedical Engineering (BME) is a new, multidisciplinary, and rapidly growing field, however, the BME Workforce suffers from limited ethnic and gender diversity. Despite the demand and growth of this new field due to its public health importance, only 4 out of the 107 Historically Black Colleges and Universities (HBCUs) nationwide offers a Bachelor's of Science (B.S.) in Bio-Engineering related fields. In order to contribute to a growing BME Workforce, HBCUs need to react and offer more degree-programs relevant to BME...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28322140/applications-and-risks-of-nanomaterials-used-in-regenerative-medicine-delivery-systems-theranostics-and-therapy
#8
REVIEW
Estefany I Medina-Reyes, Danae Garcia-Viacobo, Franklin A Carrero-Martinez, Yolanda Irasema Chirino
Recent advances in nanotechnology have transformed the biomedicine field, in which the use of engineered nanomaterials (ENMs) has provided the foundation for novel applications. For this reason, the number of ENMs has increased rapidly, and here we provide a classification of ENMs based on chemical composition and biomedical applications, which include regenerative medicine, delivery systems, theranostics, and therapy. These have been identified as the most advanced and promising areas for further studies with humans...
2017: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/28319779/supramolecular-biofunctional-materials
#9
REVIEW
Jie Zhou, Jie Li, Xuewen Du, Bing Xu
This review discusses supramolecular biofunctional materials, a novel class of biomaterials formed by small molecules that are held together via noncovalent interactions. The complexity of biology and relevant biomedical problems not only inspire, but also demand effective molecular design for functional materials. Supramolecular biofunctional materials offer (almost) unlimited possibilities and opportunities to address challenging biomedical problems. Rational molecular design of supramolecular biofunctional materials exploit powerful and versatile noncovalent interactions, which offer many advantages, such as responsiveness, reversibility, tunability, biomimicry, modularity, predictability, and, most importantly, adaptiveness...
March 12, 2017: Biomaterials
https://www.readbyqxmd.com/read/28315813/the-case-for-applying-tissue-engineering-methodologies-to-instruct-human-organoid-morphogenesis
#10
REVIEW
Carlos R Marti-Figueroa, Randolph S Ashton
Three-dimensional organoids derived from human pluripotent stem cell (hPSC) derivatives have become widely used in vitro models for studying development and disease. Their ability to recapitulate facets of normal human development during in vitro morphogenesis produces tissue structures with unprecedented biomimicry. Current organoid derivation protocols primarily rely on spontaneous morphogenesis processes to occur within 3-D spherical cell aggregates with minimal to no exogenous control. This yields organoids containing microscale regions of biomimetic tissues, but at the macroscale (i...
March 15, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28315745/production-of-low-expressing-recombinant-cationic-biopolymers-with-high-purity
#11
Xuguang Chen, Alireza Nomani, Niket Patel, Arash Hatefi
The growing complexity of recombinant biopolymers for delivery of bioactive agents requires the ability to control the biomaterial structure with high degree of precision. Genetic engineering techniques have provided this opportunity to synthesize biomaterials in an organism such as E. coli with full control over their lengths and sequences. One class of such biopolymers is recombinant cationic biopolymers with applications in gene delivery, regenerative medicine and variety of other biomedical applications...
March 15, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/28315408/stemtextsearch-stem-cell-gene-database-with-evidence-from-abstracts
#12
Chou-Cheng Chen, Chung-Liang Ho
BACKGROUND: Previous studies have used many methods to find biomarkers in stem cells, including text mining, experimental data and image storage. However, no text-mining methods have yet been developed which can identify whether a gene plays a positive or negative role in stem cells. DESCRIPTION: StemTextSearch identifies the role of a gene in stem cells by using a text-mining method to find combinations of gene regulation, stem-cell regulation and cell processes in the same sentences of biomedical abstracts...
March 14, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28303994/association-of-il-6-c-174g-rs-1800795-single-nucleotide-polymorphism-with-type-2-diabetes-mellitus-in-pakistani-population
#13
Amina Nadeem, Sadaf Mumtaz, Abdul Khaliq Naveed, Qaiser Mansoor, Muhammad Aslam, Arif Siddiqui, Muhammad Ismail
OBJECTIVE: To determine the association of interleukin-6 C-174G single nucleotide polymorphism with type 2 diabetes mellitus and metabolic parameters. METHODS: This case-control study was conducted from June 2012 to December 2013 at the Military Hospital Rawalpindi, the Centre for Research in Experimental and Applied Medicine, Army Medical College, Rawalpindi, and the Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan. Two cohorts of subjects were genotyped for the single nucleotide polymorphism...
March 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28301736/epigenetic-regulation-a-new-frontier-for-biomedical-engineers
#14
Zhen Chen, Shuai Li, Shankar Subramaniam, John Y-J Shyy, Shu Chien
Gene expression in mammalian cells depends on the epigenetic status of the chromatin, including DNA methylation, histone modifications, promoter-enhancer interactions, and noncoding RNA-mediated regulation. The coordinated actions of these multifaceted regulations determine cell development, cell cycle regulation, cell state and fate, and the ultimate responses in health and disease. Therefore, studies of epigenetic modulations are critical for our understanding of gene regulation mechanisms at the molecular, cellular, tissue, and organ levels...
March 6, 2017: Annual Review of Biomedical Engineering
https://www.readbyqxmd.com/read/28301735/glutaminolysis-a-hallmark-of-cancer-metabolism
#15
Lifeng Yang, Sriram Venneti, Deepak Nagrath
Glutamine is the most abundant circulating amino acid in blood and muscle and is critical for many fundamental cell functions in cancer cells, including synthesis of metabolites that maintain mitochondrial metabolism; generation of antioxidants to remove reactive oxygen species; synthesis of nonessential amino acids (NEAAs), purines and pyrimidines, and fatty acids for cellular replication; and activation of cell signaling. In light of the pleiotropic role of glutamine in cancer cells, a comprehensive understanding of glutamine metabolism is essential for the development of metabolic therapeutic strategies for targeting cancer cells...
March 8, 2017: Annual Review of Biomedical Engineering
https://www.readbyqxmd.com/read/28301734/deep-learning-in-medical-image-analysis
#16
Dinggang Shen, Guorong Wu, Heung-Il Suk
This review covers computer-assisted analysis of images in the field of medical imaging. Recent advances in machine learning, especially with regard to deep learning, are helping to identify, classify, and quantify patterns in medical images. At the core of these advances is the ability to exploit hierarchical feature representations learned solely from data, instead of features designed by hand according to domain-specific knowledge. Deep learning is rapidly becoming the state of the art, leading to enhanced performance in various medical applications...
March 9, 2017: Annual Review of Biomedical Engineering
https://www.readbyqxmd.com/read/28300586/pectins-functionalized-biomaterials-a-new-viable-approach-for-biomedical-applications-a-review
#17
Aqdas Noreen, Zill-I-Huma Nazli, Javeria Akram, Ijaz Rasul, Asim Mansha, Nazia Yaqoob, Rehana Iqbal, Shazia Tabasum, Mohammad Zuber, Khalid Mahmood Zia
Pectins are natural complex heteropolysaccharides, composed of (1, 4)-linked α-D-galacturonic acid residues and variety of neutral sugars such as rhamnose, galactose, arabinose. It is second most abundant component of the cell wall of all land plants. It has wide applications in various fields due to its use as gelling, emulsifying or stabilizing agent and as well as its non-toxic, biocompatible and biodegradable nature. Considering these versatile properties this review sheds a light on the synthesis, modification, characterization and applications of pectin based polymers...
March 11, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28300393/remote-control-and-modulation-of-cellular-events-by-plasmonic-gold-nanoparticles-implications-and-opportunities-for-biomedical-applications
#18
Jiayang Li, Jing Liu, Chunying Chen
Compared to traditional hyperthermia methods, gold nanoparticles (Au NPs) successfully achieve site-specific incremental temperature in deep tissues. By virtue of near-infrared (NIR) laser-mediated photothermal treatment, Au NPs have been widely explored in clinical and preclinical applications, including cancer therapy and tissue engineering. In this issue of ACS Nano, Suzuki, Ciofani, and colleagues demonstrate how gold nanoshells can remotely activate striated muscle cells via inducing myotube contraction and modulating related gene expression by mild heat stimulation under NIR irradiation...
March 16, 2017: ACS Nano
https://www.readbyqxmd.com/read/28299940/epsilon-q-an-automated-analyzer-interface-for-mass-spectral-library-search-and-label-free-protein-quantification
#19
Jin-Young Cho, Hyoung-Joo Lee, Seul-Ki Jeong, Young-Ki Paik
Mass spectrometry (MS) is a widely used proteome analysis tool for biomedical science. In an MS-based bottom-up proteomic approach to protein identification, sequence database (DB) searching has been routinely used because of its simplicity and convenience. However, searching a sequence DB with multiple variables and modification options can increase processing time and false-positive errors in large and complicated MS datasets. Spectral library searching is an alternative solution, avoiding the limitations of sequence DB searching and allowing the detection of more peptides with high sensitivity...
March 16, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28298238/biofed-federated-query-processing-over-life-sciences-linked-open-data
#20
Ali Hasnain, Qaiser Mehmood, Syeda Sana E Zainab, Muhammad Saleem, Claude Warren, Durre Zehra, Stefan Decker, Dietrich Rebholz-Schuhmann
BACKGROUND: Biomedical data, e.g. from knowledge bases and ontologies, is increasingly made available following open linked data principles, at best as RDF triple data. This is a necessary step towards unified access to biological data sets, but this still requires solutions to query multiple endpoints for their heterogeneous data to eventually retrieve all the meaningful information. Suggested solutions are based on query federation approaches, which require the submission of SPARQL queries to endpoints...
March 15, 2017: Journal of Biomedical Semantics
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