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Biomedical engineering

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https://www.readbyqxmd.com/read/29664886/history-of-the-development-of-anesthesia-for-the-dolphin-a-quest-to-study-a-brain-as-large-as-man-s
#1
James G McCormick, Sam H Ridgway
It is important for academic-minded human anesthesiologists to have an interdisciplinary perspective when engaging in cutting-edge research as well as the practice of human anesthesiology. This was a philosophy promoted by Dr. Robert Dripps, former pioneering Chairman of the Anesthesiology Department at the University of Pennsylvania (Philadelphia, Pennsylvania). Many human and veterinary anesthesiologists as well as biomedical engineers and neuroscientists benefited from Dr. Dripps's constructive outlook personified in the quest to develop dolphin anesthesiology...
April 17, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29664609/using-an-engineered-galvanic-redox-system-to-generate-positive-surface-potentials-that-promote-osteogenic-functions
#2
Yulong Zhang, Zhong Zheng, Mengliu Yu, Chinyun Hsu, Emily Berthiaume, Hsinchuan Pan, Xinli Zhang, Adam Z Stieg, Benjamin Wu, Huiming Wang, Kang Ting, Chia Soo
Successful osseointegration of orthopaedic and orthodontic implants is dependent on a competition between osteogenesis and bacterial contamination on the implant-tissue interface. Previously, by taking advantage of the highly interactive capabilities of silver nanoparticles (AgNPs), we effectively introduced an antimicrobial effect to metal implant materials using a AgNP/poly(DL-lactic-co-glycolic acid) (PLGA) coating. Although electrical forces have been shown to promote osteogenesis, creating practical materials and devices capable of harnessing these forces to induce bone regeneration remains challenging...
April 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29664602/engineering-persistent-luminescence-nanoparticles-for-biological-applications-from-biosensing-bioimaging-to-theranostics
#3
Shao-Kai Sun, He-Fang Wang, Xiu-Ping Yan
Persistent luminescence nanoparticles (PLNPs) are unique optical materials emitting long-lasting luminescence after ceasing excitation. Such a unique optical feature allows luminescence detection without constant external illumination to avoid the interferences of autofluorescence and scattering light from biological fluids and tissues. Besides, near-infrared (NIR) PLNPs have advantages of deep penetration and the reactivation of the persistent luminescence (PL) by red or NIR light. These features make the application of NIR-emitting PLNPs in long-term bioimaging no longer limited by the lifetime of PL...
April 17, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29664220/double-network-hydrogel-for-tissue-engineering
#4
REVIEW
Zhipeng Gu, Keqing Huang, Yan Luo, Laibao Zhang, Tairong Kuang, Zhou Chen, Guochao Liao
Double network (DN) hydrogels, a kind of promising soft and tough hydrogels, are produced by two unique contrasting networks with designed network entanglement burst into the field of materials science as versatile functional systems for a very broad range of applications. A part of the DN hydrogels is characterized by extraordinary mechanical properties providing efficient biocompatible and high strength for holding considerable promise in tissue engineering. Following DN hydrogels principles and consideration of biomedical applications, we provide an overall view of the present various DN hydrogels and look forward to the future of DN hydrogels for tissue engineering...
April 17, 2018: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/29663543/surface-nanopore-engineering-of-2d-mxenes-for-targeted-and-synergistic-multitherapies-of-hepatocellular-carcinoma
#5
Zhenli Li, Han Zhang, Jun Han, Yu Chen, Han Lin, Tian Yang
Hepatocellular carcinoma (HCC) is one of the most common and deadly gastrointestinal malignancies. Given its insensitivity to traditional systematic chemotherapy, new therapeutic strategies for efficient HCCs treatment are urgently needed. Here, the development of a novel 2D MXene-based composite nanoplatform for highly efficient and synergistic chemotherapy and photothermal hyperthermia against HCC is reported. A surface-nanopore engineering strategy is developed for the MXenes' surface functionalization, which achieves the uniform coating of a thin mesoporous-silica layer onto the surface of 2D Ti3 C2 MXene (Ti3 C2 @mMSNs)...
April 16, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29661307/effect-of-ph-and-precursor-salts-on-in-situ-formation-of-calcium-phosphate-nanoparticles-in-methylcellulose-hydrogel
#6
Min Hee Kim, Hanna Park, Won Ho Park
Thermo-reversible hydrogels have been widely studied in biomedical research fields, because of their potential performance in drug delivery and tissue engineering. In this study, a novel thermo-sensitive methylcellulose (MC) hydrogel based on calcium phosphate nanoparticles (CaP NPs) was prepared by in situ formation process in which precursor salts induced a salt-out effect in the MC solution. Based on the Hofmeister series, CaCl2 , Na2 HPO4 , and NaH2 PO4 precursor salts with a good salt-out effect were used as the precursor salts for CaP NPs...
July 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29660635/caffeine-catalyzed-gels
#7
Angela M DiCiccio, Young-Ah Lucy Lee, Dean L Glettig, Elizabeth S E Walton, Eva L de la Serna, Veronica A Montgomery, Tyler M Grant, Robert Langer, Giovanni Traverso
Covalently cross-linked gels are utilized in a broad range of biomedical applications though their synthesis often compromises easy implementation. Cross-linking reactions commonly utilize catalysts or conditions that can damage biologics and sensitive compounds, producing materials that require extensive post processing to achieve acceptable biocompatibility. As an alternative, we report a batch synthesis platform to produce covalently cross-linked materials appropriate for direct biomedical application enabled by green chemistry and commonly available food grade ingredients...
April 6, 2018: Biomaterials
https://www.readbyqxmd.com/read/29660456/chitosan-based-hydrogels-preparation-properties-and-applications
#8
Zahra Shariatinia, Azin Mazloom Jalali
Chitosan (CS), the second most plentiful natural polysaccharide next to cellulose, has valuable characteristics including biocompatibility, nontoxicity and biodegradability. CS is broken down in the human body to innocuous products (amino sugars). Hydrogels are polymeric materials with three dimensional networks retaining a huge quantity of water within their structures which are of great interest in biomedical/environmental applications. Usually, injectable hydrogels have functional groups which are sensitive to pH, temperature or irradiation stimuli...
April 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29659507/customized-peptide-biomaterial-synthesis-via-an-environment-reliant-auto-programmer-stigmergic-approach
#9
Ravindra V Badhe, Pradeep Kumar, Yahya E Choonara, Thashree Marimuthu, Lisa C du Toit, Divya Bijukumar, Dharmesh R Chejara, Mostafa Mabrouk, Viness Pillay
Stigmergy, a form of self-organization, was employed here to engineer a self-organizing peptide capable of forming a nano- or micro-structure and that can potentially be used in various drug delivery and biomedical applications. These self-assembling peptides exhibit several desirable qualities for drug delivery, tissue engineering, cosmetics, antibiotics, food science, and biomedical surface engineering. In this study, peptide biomaterial synthesis was carried out using an environment-reliant auto-programmer stigmergic approach...
April 16, 2018: Materials
https://www.readbyqxmd.com/read/29657854/targeted-drug-discovery-and-development-from-molecular-signaling-to-the-global-market-an-educational-program-at-new-york-university-5-year-metrics
#10
Gloria Lee, Joseph Plaksin, Ravichandran Ramasamy, Gabrielle Gold-von Simson
Drug discovery and development (DDD) is a collaborative, dynamic process of great interest to researchers, but an area where there is a lack of formal training. The Drug Development Educational Program (DDEP) at New York University was created in 2012 to stimulate an improved, multidisciplinary DDD workforce by educating early stage scientists as well as a variety of other like-minded students. The first course of the program emphasizes post-compounding aspects of DDD; the second course focuses on molecular signaling pathways...
2018: Journal of Translational Science
https://www.readbyqxmd.com/read/29657233/reproductive-technologies-for-the-generation-and-maintenance-of-valuable-animal-strains
#11
Takehito Kaneko
Many types of mutant and genetically engineered strains have been produced in various animal species. Their numbers have dramatically increased in recent years, with new strains being rapidly produced using genome editing techniques. In the rat, it has been difficult to produce knockout and knock-in strains because the establishment of stem cells has been insufficient. However, a large number of knockout and knock-in strains can currently be produced using genome editing techniques, including zinc-finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN), and the clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein 9 (Cas9) system...
April 14, 2018: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/29652594/tissue-engineering-and-regenerative-medicine-2017-a-year-in-review
#12
Kyung Min Park, Young Min Shin, Kyobum Kim, Heungsoo Shin
In 2017, a new paradigm change caused by artificial intelligence and big data analysis resulted in innovation in each field of science and technology, and also significantly influenced progress in tissue engineering and regenerative medicine (TERM). TERM has continued to make technological advances based on interdisciplinary approaches and has contributed to the overall field of biomedical technology including cancer biology, personalized medicine, development biology, and cell-based therapeutics. While researchers are aware that there is still a long way to go until TERM reaches the ultimate goal of patient treatment through clinical translation, the rapid progress in convergence studies led by technological improvements in TERM has been encouraging...
March 13, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29621404/inorganic-nanomaterials-for-soft-tissue-repair-and-regeneration
#13
Russell Urie, Deepanjan Ghosh, Inam Ridha, Kaushal Rege
Inorganic nanomaterials have witnessed significant advances in areas of medicine including cancer therapy, imaging, and drug delivery, but their use in soft tissue repair and regeneration is in its infancy. Metallic, ceramic, and carbon allotrope nanoparticles have shown promise in facilitating tissue repair and regeneration. Inorganic nanomaterials have been employed to improve stem cell engraftment in cellular therapy, material mechanical stability in tissue repair, electrical conductivity in nerve and cardiac regeneration, adhesion strength in tissue approximation, and antibacterial capacity in wound dressings...
April 5, 2018: Annual Review of Biomedical Engineering
https://www.readbyqxmd.com/read/29620843/biofunctionalized-3d-nanopillar-arrays-fostering-cell-guidance-and-promoting-synapse-stability-and-neuronal-activity-in-networks
#14
Hayder Amin, Michele Dipalo, Francesco De Angelis, Luca Berdondini
A controlled geometry of in vitro neuronal networks allows investigation of the cellular mechanisms that underlie neuron-to-neuron and neuron-extracellular matrix interactions, which are essential to biomedical research. Herein, we report a selective guidance of primary hippocampal neurons by using arrays of three-dimensional vertical nanopillars (NPs) functionalized with a specific adhesion-promoting molecule-poly-dl-ornithine (PDLO). We show that 90% of neuronal cells are guided exclusively on the combinatorial PDLO/NP substrate...
April 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29619243/two-dimensional-material-based-bionano-platforms-to-control-mesenchymal-stem-cell-differentiation
#15
REVIEW
Ee-Seul Kang, Da-Seul Kim, Intan Rosalina Suhito, Wanhee Lee, Inbeom Song, Tae-Hyung Kim
Background: In the past decade, stem cells, with their ability to differentiate into various types of cells, have been proven to be resourceful in regenerative medicine and tissue engineering. Despite the ability to repair damaged parts of organs and tissues, the use of stem cells still entails several limitations, such as low differentiation efficiency and difficulties in guiding differentiation. To address these limitations, nanotechnology approaches have been recently implemented in stem cell research...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29618224/advances-in-multicompartment-mesoporous-silica-micro-nanoparticles-for-theranostic-applications
#16
Jian Liu, Tingting Liu, Jian Pan, Shaomin Liu, G Q Max Lu
Mesoporous silica nanoparticles (MSNs) are promising functional nanomaterials for a variety of biomedical applications, such as bioimaging, drug/gene delivery, and cancer therapy. This is due to their low density, low toxicity, high biocompatibility, large specific surface areas, and excellent thermal and mechanical stability. The past decade has seen rapid advances in the development of MSNs with multiple compartments. These include hierarchical porous structures and core-shell, yolk-shell, and Janus structured particles for efficient diagnosis and therapeutic applications...
April 4, 2018: Annual Review of Chemical and Biomolecular Engineering
https://www.readbyqxmd.com/read/29618223/structural-dna-nanotechnology-artificial-nanostructures-for-biomedical-research
#17
Yonggang Ke, Carlos Castro, Jong Hyun Choi
Structural DNA nanotechnology utilizes synthetic or biologic DNA as designer molecules for the self-assembly of artificial nanostructures. The field is founded upon the specific interactions between DNA molecules, known as Watson-Crick base pairing. After decades of active pursuit, DNA has demonstrated unprecedented versatility in constructing artificial nanostructures with significant complexity and programmability. The nanostructures could be either static, with well-controlled physicochemical properties, or dynamic, with the ability to reconfigure upon external stimuli...
April 4, 2018: Annual Review of Biomedical Engineering
https://www.readbyqxmd.com/read/29617111/highly-sensitive-multifilament-fiber-strain-sensors-with-ultra-broad-sensing-range-for-textile-electronics
#18
Jaehong Lee, Sera Shin, Sanggeun Lee, Jaekang Song, Subin Kang, Heetak Han, SeulGee Kim, Seunghoe Kim, Jungmok Seo, DaeEun Kim, Taeyoon Lee
Highly stretchable fiber strain sensors are one of the most important components for various applications in wearable electronics, electronic textiles and biomedical electronics. Herein, we present a facile approach for fabricating highly stretchable and sensitive fiber strain sensors by embedding Ag nanoparticles into a stretchable fiber with a multifilament structure. The multifilament structure and Ag-rich shells of the fiber strain sensor enable the sensor to simultaneously achieve both a high sensitivity and largely wide sensing range despite its simple fabrication process and components...
April 4, 2018: ACS Nano
https://www.readbyqxmd.com/read/29616431/cuttlebone-as-a-marine-derived-material-for-preparing-bone-grafts
#19
Alisa Palaveniene, Volodymyr Harkavenko, Vitalina Kharchenko, Povilas Daugela, Mindaugas Pranskunas, Gintaras Juodzbalys, Nataliya Babenko, Jolanta Liesiene
The use of synthetic materials for biomedical applications still presents issues owing to the potential for unfavourable safety characteristics. Currently, there is increasing interest in using natural, marine-derived raw materials for bone tissue engineering. In our study, the endoskeleton of the mollusc Sepia, i.e. cuttlebone (CB), was used with regenerated cellulose (RC) to prepare three-dimensional composite bone grafts. CB microparticles were mechanically immobilised within a cellulose gel, resulting in a macroporous structure upon lyophilisation...
April 3, 2018: Marine Biotechnology
https://www.readbyqxmd.com/read/29611579/dna-metallization-principles-methods-structures-and-applications
#20
REVIEW
Zhaowei Chen, Chaoqun Liu, Fangfang Cao, Jinsong Ren, Xiaogang Qu
DNA metallization has witnessed tremendous growth and development, from the initial simple synthesis aimed at manufacturing conductive metal nanowires to the current fabrication of various nanostructures for applications in areas as diverse as nanolithography, energy conversion and storage, catalysis, sensing, and biomedical engineering. To this, our aim here was to present a comprehensive review to summarize the research activities on DNA metallization that have appeared since the concept was first proposed in 1998...
April 3, 2018: Chemical Society Reviews
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