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https://www.readbyqxmd.com/read/28716454/a-randomised-trial-of-screening-with-digital-breast-tomosynthesis-plus-conventional-digital-2d-mammography-versus-2d-mammography-alone-in-younger-higher-risk-women
#1
Anthony J Maxwell, Michael Michell, Yit Y Lim, Susan M Astley, Mary Wilson, Emma Hurley, D Gareth Evans, Anthony Howell, Asif Iqbal, John Kotre, Stephen Duffy, Julie Morris
INTRODUCTION: Digital breast tomosynthesis (DBT) has been shown to increase invasive cancer detection rates at screening compared to full field digital (2D) mammography alone, and some studies have reported a reduction in the screening recall rate. No prospective randomised studies of DBT have previously been published. This study compares recall rates with 2D mammography with and without concurrent DBT in women in their forties with a family history of breast cancer undergoing incident screening...
June 30, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28715278/bi-rads-category-3-comparison-probably-benign-category-after-recall-from-screening-before-and-after-implementation-of-digital-breast-tomosynthesis
#2
Elizabeth S McDonald, Anne Marie McCarthy, Susan P Weinstein, Mitchell D Schnall, Emily F Conant
Purpose To evaluate Breast Imaging Reporting and Data System (BI-RADS) category 3 assessment at diagnostic examination after recall from screening in a large urban population after implementation of digital breast tomosynthesis (DBT) by focusing both on overall use and use stratified by recalled finding type and outcome at 2 years. Materials and Methods This was an intuitional review board-approved and HIPAA-compliant retrospective review of 10 728 digital mammography (DM) examinations from September 1, 2010, to August 30, 2011, and 15 571 screening DBT examinations from October 1, 2011, to February 28, 2013...
July 17, 2017: Radiology
https://www.readbyqxmd.com/read/28714517/overexpression-of-the-erythropoietin-receptor-in-rama-37-breast-cancer-cells-alters-cell-growth-and-sensitivity-to-tamoxifen
#3
Lenka Ilkovičová, Nina Trošt, Erika Szentpéteriová, Peter Solár, Radovan Komel, Nataša Debeljak
Erythropoietin (EPO) is the main regulator of erythropoiesis, and its receptor (EPOR) is expressed in various tissues, including tumors. Expression of EPOR in breast cancer tissue has been shown to correlate with expression of the estrogen receptor (ER). However, EPOR promotes proliferation in an EPO-independent manner. In patients with breast cancer, EPOR is associated with impaired tamoxifen response in ER-positive tumors, but not in ER-negative tumors. Furthermore, a positive correlation between EPOR/ER status and increased local cancer recurrence has been demonstrated, and EPOR expression is associated with G-protein coupled ER (GPER)...
August 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28713712/management-of-gigantomastia-outcomes-of-superomedial-pedicle-with-vertical-scar-or-wise-pattern-skin-excision
#4
Mehmet Can Sak, Selcuk Akın, Burak Ersen, Orhan Tunalı, Aksu Ismail
BACKGROUND: Gigantomastia is a rare condition characterized by excessive breast growth and can be physically and psychosocially disabling for the patient. Regarding management of gigantomastia, this study evaluates the outcomes of superomedial pedicle with vertical scar or wise pattern skin excision. METHODS: A total of 425 patients who underwent reduction mammoplasty in our institution were reviewed. Forty eight reduction mammoplasty patients with resection weights greater than 1 kg per breast and treated with superomedial dermoglandular pedicle technique combined with vertical or wise-pattern skin excision were included...
May 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28713391/apoptosis-induced-via-gamma-delta-t-cell-antigen-receptor-blocking-antibodies-a-cautionary-tale
#5
Indrani Dutta, Lynne-Marie Postovit, Gabrielle M Siegers
Mechanistic studies contribute greatly to our understanding of γδ T cell (γδTc) biology, aiding development of these cells as immunotherapeutic agents. The antibody blocking assay is an accepted method to determine the receptors involved in γδTc killing of tumor targets. Effectors and/or targets are preincubated with microgram quantities of monoclonal antibodies (mAb), often described by commercial sources to be useful for blocking assays. We and others have used such assays extensively in the past, correlating decreases in cytotoxicity against specific targets with involvement of the blocked receptor(s)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28710865/neoadjuvant-chemotherapy-in-triple-negative-breast-cancer-a-multicentric-retrospective-observational-study-in-real-life-setting
#6
Teresa Gamucci, Laura Pizzuti, Isabella Sperduti, Lucia Mentuccia, Angela Vaccaro, Luca Moscetti, Paolo Marchetti, Luisa Carbognin, Andrea Michelotti, Laura Iezzi, Alessandra Cassano, Antonino Grassadonia, Antonio Astone, Andrea Botticelli, Emanuela Magnolfi, Luigi Di Lauro, Domenico Sergi, Paola Fuso, Nicola Tinari, Maddalena Barba, Marcello Maugeri-Saccà, Elisabetta Landucci, Francesca Conti, Giuseppe Sanguineti, Michele De Tursi, Gianni Iafrate, Antonio Giordano, Gennaro Ciliberto, Clara Natoli, Patrizia Vici
We aimed to assess the efficacy of neoadjuvant chemotherapy (NACT) in a cohort of 213 triple-negative breast cancer (TNBC) patients treated in real-world practice at 8 Italian cancer centres. We computed descriptive statistics for all the variable of interest. Factors testing significant in univariate analysis were included in multivariate models. Survival data were compared by Kaplan-Meier curves and log-rank test. The median follow-up was 45 months. We observed 60 (28.2%) pathological complete response (pCR)...
July 15, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28710021/identification-of-tumor-autonomous-and-indirect-effects-of-vitamin-d-action-that-inhibit-breast-cancer-growth-and-tumor-progression
#7
REVIEW
Abhishek Aggarwal, David Feldman, Brian J Feldman
Several epidemiological studies have found that low vitamin D levels are associated with worse prognosis and poorer outcomes in patients with breast cancer (BCa), although some studies have failed to find this association. In addition, prior research has found that BCa patients with vitamin D deficiency have a more aggressive molecular phenotype and worse prognostic biomarkers. As vitamin D deficiency is common in patients diagnosed with BCa, elucidating the cause of the association between poor outcomes and vitamin D deficiency promises to have a significant impact on improving care for patients with BCa including enabling the development of novel therapeutic approaches...
July 11, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28709956/activation-of-human-gonadotropin-releasing-hormone-receptor-promotes-down-regulation-of-arhgap18-and-regulates-the-cell-invasion-of-mda-mb-231%C3%A2-cells
#8
Arturo Aguilar-Rojas, Guadalupe Maya-Núñez, Maira Huerta-Reyes, Marco Allán Pérez-Solis, Raúl Silva-García, Nancy Guillén, Jean-Christophe Olivo-Marin
The Gonadotropin-Releasing Hormone Receptor (GnRHR) is expressed mainly in the gonadotrope membrane of the adenohypophysis and its natural ligand, the Gonadotropin-Releasing Hormone (GnRH), is produced in anterior hypothalamus. Furthermore, both molecules are also present in the membrane of cells derived from other reproductive tissues such as the breast, endometrium, ovary, and prostate, as well as in tumors derived from these tissues. The functions of GnRH receptor and its hormone in malignant cells have been related with the decrease of proliferation and the invasiveness of those tumors however, little is known about the molecules associated with the signaling pathways regulated by both molecules in malignant cells...
July 11, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28708720/predicting-neoadjuvant-chemotherapy-in-nonconcentric-shrinkage-pattern-of-breast-cancer-using-1h-magnetic-resonance-spectroscopic-imaging
#9
Juan Zhou, Peng-Gang Qiao, Hong-Tao Zhang, Gong-Jie Li, Ze-Fei Jiang
OBJECTIVE: The aim of this study was to explore the response to neoadjuvant chemotherapy (NAC) in nonconcentric shrinkage pattern of breast cancer (BC) patients using H-magnetic resonance spectroscopy. METHODS: Twenty-five BC patients were the study cohort. All patients received AT-based regimen as first-line treatment. Tumor response to chemotherapy was evaluated after the second and fourth cycles using magnetic resonance imaging and magnetic resonance spectroscopy...
July 13, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28707320/homology-model-of-the-human-trna-splicing-ligase-rtcb
#10
Argha Nandy, Patricia Saenz-Mendez, Adrienne M Gorman, Afshin Samali, Leif A Eriksson
RtcB is an essential human tRNA ligase required for ligating the 2',3'-cyclic phosphate and 5'-hydroxyl termini of cleaved tRNA halves during tRNA splicing and XBP1 fragments during endoplasmic reticulum stress. Activation of XBP1 has been implicated in various human tumors including breast cancer. Here we present, for the first time, a homology model of human RtcB (hRtcB) in complex with manganese and covalently bound GMP built from the Pyrococcus horikoshii RtcB (bRtcB) crystal structure, PDB ID 4DWQA. The structure is analyzed in terms of stereochemical quality, folding reliability, secondary structure similarity with bRtcB, druggability of the active site binding pocket and its metal-binding microenvironment...
July 13, 2017: Proteins
https://www.readbyqxmd.com/read/28705918/in-vivo-quantification-of-er-%C3%AE-expression-by-pharmacokinetic-modeling-studies-with-18-f-fhnp-pet
#11
Inês F Antunes, Antoon T M Willemsen, Jurgen W A Sijbesma, Ate S Boerema, Aren van Waarde, Andor W J M Glaudemans, Rudi A Dierckx, Elisabeth G E de Vries, Geke A P Hospers, Erik F de Vries
The estrogen receptor (ER) is a target for endocrine therapy in breast cancer patients. Individual quantification of ERα and ERβ expression, rather than total ER levels, might enable better prediction of the response to treatment. We recently developed the tracer 2-(18)F-fluoro-6-(6-hydroxynaphthalen-2-yl)pyridin-3-ol ((18)F-FHNP) for assessment of ERβ levels with positron emission tomography (PET). Here we investigated several pharmacokinetic analysis methods to quantify changes in ERβ availability with (18)F-FHNP-PET...
July 13, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28705171/formula-diet-driven-microbiota-shifts-tryptophan-metabolism-from-serotonin-to-tryptamine-in-neonatal-porcine-colon%C3%AF
#12
Manish Kumar Saraf, Brian D Piccolo, Anne K Bowlin, Kelly E Mercer, Tanya LeRoith, Sree V Chintapalli, Kartik Shankar, Thomas M Badger, Laxmi Yeruva
BACKGROUND: The gut microbiota of breast-fed and formula-fed infants differ significantly, as do the risks for allergies, gut dysfunction, and upper respiratory tract infections. The connections between breast milk, various formulas, and the profiles of gut bacteria to these childhood illnesses, as well as the mechanisms underlying the effects, are not well understood. METHODS: We investigated distal colon microbiota by 16S RNA amplicon sequencing, morphology by histomorphometry, immune response by cytokine expression, and tryptophan metabolism in a pig model in which piglets were sow-fed, or fed soy or dairy milk-based formula from postnatal day (PND) 2 to 21...
July 14, 2017: Microbiome
https://www.readbyqxmd.com/read/28705082/projected-improvements-in-accelerated-partial-breast-irradiation-using-a-novel-breast-stereotactic-radiotherapy-device-a-dosimetric-analysis
#13
James W Snider, Yildirim Mutaf, Elizabeth Nichols, Andrea Hall, Patrick Vadnais, William F Regine, Steven J Feigenberg
Accelerated partial breast irradiation has caused higher than expected rates of poor cosmesis. At our institution, a novel breast stereotactic radiotherapy device has demonstrated dosimetric distributions similar to those in brachytherapy. This study analyzed comparative dose distributions achieved with the device and intensity-modulated radiation therapy accelerated partial breast irradiation. Nine patients underwent computed tomography simulation in the prone position using device-specific immobilization on an institutional review board-approved protocol...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28704214/bile-acids-upregulate-brca1-and-downregulate-estrogen-receptor-1-gene-expression-in-ovarian-cancer-cells
#14
Qunyan Jin, Olivier Noel, Mai Nguyen, Lionel Sam, Glenn S Gerhard
Two major risk factors for ovarian cancer include loss-of-function mutations in the BRCA1 (breast cancer 1, early onset) gene and aspects of estrogen metabolism. Modulation of the levels of the normal BRCA1 allele and estrogen receptor expression may therefore be a preventive strategy. Consensus binding motifs for the bile acid-responsive transcription factor farnesoid X receptor were identified in the BRCA1 and estrogen receptor 1 (ESR1) and estrogen receptor 2 (ESR2) genes, supported by chromatin immunoprecipitation sequencing data...
July 12, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28703043/acid-sensitive-lipidated-doxorubicin-prodrug-entrapped-in-nanoemulsion-impairs-lung-tumor-metastasis-in-a-breast-cancer-model
#15
Ana Lygia Dos Santos Câmara, Gregor Nagel, Harald R Tschiche, Camila Magalhães Cardador, Luis Alexandre Muehlmann, Daniela Mara de Oliveira, Paula Queiroz Alvim, Ricardo Bentes Azevedo, Marcelo Calderón, João Paulo Figueiró Longo
AIM: To develop an acid-sensitive lipidated, doxorubicin (Dox) prodrug (C16-Dox) to be entrapped in lipid nanoemulsion (NE-C16-Dox) as a nanocarrier to treat breast cancer models (in vitro and in vivo). RESULTS: We report the efficacy of NE-C16-Dox in in vitro experiments, as well as the improved chemotherapeutic index and tumor-control efficacy compared with treatment with free Dox in an in vivo murine 4T1 breast cancer model. In addition, NE-C16-Dox allowed the use of a higher dose of Dox, acceptable biocompatibility and a significant reduction in lung metastasis...
July 13, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28702618/copper-ii-complexes-of-functionalized-2-2-6-2-terpyridines-and-2-6-di-thiazol-2-yl-pyridine-structure-spectroscopy-cytotoxicity-and-catalytic-activity
#16
Katarzyna Czerwińska, Barbara Machura, Slawomir Kula, Stanisław Krompiec, Karol Erfurt, Catarina Roma-Rodrigues, Alexandra R Fernandes, Lidia S Shul'pina, Nikolay S Ikonnikov, Georgiy B Shul'pin
Six new copper(ii) complexes with 2,2':6',2''-terpyridine (4'-R(n)-terpy) [1 (R(1) = furan-2-yl), 2 (R(2) = thiophen-2-yl), and 3 (R(3) = 1-methyl-1H-pyrrol-2-yl)] and 2,6-di(thiazol-2-yl)pyridine derivatives (R(n)-dtpy) [4 (R(1)), 5 (R(2)), and 6 (R(3))] have been synthesized by a reaction between copper(ii) chloride and the corresponding ligand. The complexes have been characterized by UV-vis and IR spectroscopy, and their structures have been determined by X-ray analysis. The antiproliferative potential of copper(ii) complexes of 2,2':6',2''-terpyridine and 2,6-di(thiazol-2-yl)pyridine derivatives towards human colorectal (HCT116) and ovarian (A2780) carcinoma as well as towards lung (A549) and breast adenocarcinoma (MCF7) cell lines was examined...
July 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28701900/selection-of-patients-with-left-breast-cancer-for-deep-inspiration-breath-hold-radiotherapy-technique-results-of-a-prospective-study
#17
Beata Czeremszyńska, Stanisław Drozda, Michał Górzyński, Lucyna Kępka
AIM: To assess prospectively which patients with left breast cancer have the dosimetric benefit from the use of deep-inspiration breath-hold radiotherapy (DIBH-RT). BACKGROUND: Improvement in selection of patients for DIBH-RT would spare time of radiotherapy staff by removing the need for preparation of two comparative treatment plans. MATERIALS AND METHODS: Thirty-one patients qualified for whole left breast irradiation underwent breath-hold training and their free-breathing (FB) and DIBH planning-CT were included in the analysis of dosimetric outcome...
September 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28701707/anti-cancerous-effect-of-albumin-coated-silver-nanoparticles-on-mda-mb-231-human-breast-cancer-cell-line
#18
Marzieh Azizi, Hedayatoallah Ghourchian, Fatemeh Yazdian, Shahla Bagherifam, Sara Bekhradnia, Bo Nyström
With the aim of making specific targeting of silver nanoparticles as a drug for tumor cells and developing new anticancer agents, a novel nano-composite was developed. Albumin coated silver nanoparticles (ASNPs) were synthesized, and their anti-cancerous effects were evaluated against MDA-MB 231, a human breast cancer cell line. The synthesized ASNPs were characterized by spectroscopic methods. The morphological changes of the cells were observed by inverted, florescent microscopy and also by DNA ladder pattern on gel electrophoresis; the results revealed that the cell death process occurred through the apoptosis mechanism...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28700982/phosphatidylcholine-specific-phospholipase-c-inhibition-reduces-her2-overexpression-cell-proliferation-and-in-vivo-tumor-growth-in-a-highly-tumorigenic-ovarian-cancer-model
#19
Luisa Paris, Franca Podo, Francesca Spadaro, Laura Abalsamo, Maria Elena Pisanu, Alessandro Ricci, Serena Cecchetti, Luisa Altabella, Maria Buoncervello, Ludmila Lozneanu, Marina Bagnoli, Carlo Ramoni, Silvana Canevari, Delia Mezzanzanica, Egidio Iorio, Rossella Canese
Antagonizing the oncogenic effects of human epidermal growth factor receptor 2 (HER2) with current anti-HER2 agents has not yet yielded major progress in the treatment of advanced HER2-positive epithelial ovarian cancer (EOC). Using preclinical models to explore alternative molecular mechanisms affecting HER2 overexpression and oncogenicity may lead to new strategies for EOC patient treatment. We previously reported that phosphatidylcholine-specific phospholipase C (PC-PLC) exerts a pivotal role in regulating HER2 overexpression in breast cancer cells...
July 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28699804/real-world-palbociclib-dosing-patterns-and-implications-for-drug-costs-in-the-treatment-of-hr-her2-metastatic-breast-cancer
#20
Nanxin Li, Ella X Du, Lihao Chu, Miranda Peeples, Jipan Xie, Victoria Barghout, Derek H Tang
BACKGROUND: This study described real-world palbociclib dosing patterns and associated impacts on treatment costs for HR+/HER2- metastatic breast cancer (mBC) in the US. METHODS: Postmenopausal women with HR+/HER2- mBC who initiated palbociclib-based therapy (initiation date= index date) between 02/03/2015 (palbociclib approval) and 02/29/2016, and continuous quarterly activity 1 year before and 6 months after the index date, were identified in the Symphony Health Solutions database...
July 12, 2017: Expert Opinion on Pharmacotherapy
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