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Breast papilloma

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https://www.readbyqxmd.com/read/29113724/imaging-with-ultra-small-angle-x-ray-scattering-using-a-laue-case-analyzer-and-its-application-to-human-breast-tumors
#1
Daisuke Shimao, Naoki Sunaguchi, Tenta Sasaya, Tetsuya Yuasa, Shu Ichihara, Tomonori Kawasaki, Masami Ando
PURPOSE: In this study, we demonstrate a novel imaging technique, based on ultra-small-angle X-ray scattering (USAXS) that uses a Laue-case Si wafer as the angle analyzer. METHODS: We utilized the (1 1 1) diffraction plane of a 356 μm thick, symmetrically cut Si wafer as the angle analyzer, denoted by A[L]. With this device, we performed USAXS imaging experiments using 19.8 keV synchrotron X-rays. The objects we imaged were formalin-fixed, paraffin-embedded breast tumors (an invasive carcinoma and an intraductal papilloma)...
November 4, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/29075317/multiple-oncogenic-viruses-are-present-in-human-breast-tissues-before-development-of-virus-associated-breast-cancer
#2
James S Lawson, Wendy K Glenn
BACKGROUND: Multiple oncogenic viruses including, mouse mammary tumor virus, bovine leukemia virus, human papilloma virus, and Epstein Barr virus, have been identified as separate infectious pathogens in human breast cancer. Here we demonstrate that these four viruses may be present in normal and benign breast tissues 1 to 11 years before the development of same virus breast cancer in the same patients. METHODS: We combined the data we developed during investigations of the individual four oncogenic viruses and breast cancer...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29070987/results-of-short-term-follow-up-in-bi-rads-3-and-4a-breast-lesions-with-a-histological-diagnosis-of-fibroadenoma-at-percutaneous-needle-biopsy
#3
Paola Clauser, Massimo Bazzocchi, Magda Marcon, Viviana Londero, Chiara Zuiani
OBJECTIVE: To evaluate the usefulness of short-term (6 months) follow-up in patients with Breast Imaging Report and Data System (BI-RADS) 3 and 4a lesions, after a diagnosis of fibroadenoma at an image-guided biopsy. PATIENTS AND METHODS: The data of 318 women with 349 biopsy-proven fibroadenomas, a 6-month follow-up, and a follow-up of ≥ 24 months were retrospectively reviewed. Information on clinical history, lesion characteristics on ultrasound (US), mammography, and magnetic resonance imaging (MRI), BI-RADS classification, and follow-up was collected...
September 2017: Breast Care
https://www.readbyqxmd.com/read/28990682/ex-vivo-feasibility-study-of-endoscopic-intraductal-laser-ablation-of-the-breast
#4
Tjeerd de Boorder, Laurien Waaijer, Paul J van Diest, Arjen J Witkamp
OBJECTIVE: To determine the feasibility and safety of breast endoscopic thulium laser ablation for treatment of intraductal neoplasia. STUDY DESIGN: Ductoscopy is a minimally invasive endoscopic approach of the milk ducts of the breast via the nipple. Besides diagnosis in women with pathologic nipple discharge (PND), it allows non-invasive removal of intraductal lesions with a stalk like papillomas. Removal, however, is often incomplete and flat lesions cannot be targeted...
October 9, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28975808/liquid-biopsy-in-the-diagnosis-of-hpv-dna-in-breast-lesions
#5
Sabrina De Carolis, Alice Pellegrini, Donatella Santini, Claudio Ceccarelli, Antonio De Leo, Federica Alessandrini, Chiara Arienti, Sara Pignatta, Anna Tesei, Vilma Mantovani, Claudio Zamagni, Mario Taffurelli, Pasquale Sansone, Massimiliano Bonafé, Monica Cricca
AIM: HPV DNA has never been investigated in nipple discharges (ND) and serum-derived extracellular vesicles, although its presence has been reported in ductal lavage fluids and blood specimens. MATERIALS & METHODS: We analyzed 50 ND, 22 serum-derived extracellular vesicles as well as 51 pathologic breast tissues for the presence of 16 HPV DNA types. RESULTS: We show that the presence of HPV DNA in the ND is predictive of HPV DNA-positive breast lesions and that HPV DNA is more represented in intraductal papillomas...
October 4, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28872682/%C3%AE-2-himachalen-6-ol-protects-against-skin-cancer-development-in%C3%A2-vitro-and-in%C3%A2-vivo
#6
Hamid E Daaboul, Costantine F Daher, Robin I Taleb, Joelle Boulos, Kikki Bodman-Smith, Petra Boukamp, Wassim N Shebaby, Carol Dagher, Mirvat El-Sibai, Mohamad A Mroueh
BACKGROUND: Previous studies in our laboratory showed that Daucus carota oil extract (DCOE) possesses remarkable in-vitro anticancer activity and antitumour promoting effect against DMBA/TPA skin carcinogenesis in mice. Chemical analysis of DCOE led to the isolation of the β-2-himachalen-6-ol (HC), major sesquiterpene with a potent anticancer activity against various colon, breast, brain and skin cancer cells. This study investigated the anticancer activity of HC against invasive epidermal squamous cell carcinoma cells and evaluated its effect in a DMBA/TPA skin carcinogenesis Balb/c murine model...
September 5, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28861384/a-rare-presentation-of-malignant-phyllodes-tumor-with-bloody-nipple-discharge-report-of-a-case
#7
Wei-Hsin Chen
Phyllodes tumor of the breast is a rare neoplasm, particularly in young women. It is usually presented as a unilateral palpable mass and nipple discharge presented as a symptom is rare. We reported a 22-year-old Taiwanese woman in our hospital for right breast tumor with nipple discharge. Preoperative diagnosis was intraductal papilloma but the histological examination showed a malignant phyllodes tumor with intraductal growth. Symptom of nipple discharge and intraductal growth in phyllodes tumor are rare presentations...
August 2017: Gland Surgery
https://www.readbyqxmd.com/read/28845569/papillary-lesions-of-the-breast-to-excise-or-observe
#8
Sidrah Khan, Adrian Diaz, Kellie J Archer, Rebecca R Lehman, Tiffany Mullins, Gilda Cardenosa, Harry D Bear
Papillary lesions of the breast range from benign to atypical to malignant. Although papillomas without frank cancer are benign, their management remains controversial. When a core needle biopsy of a lesion yields a diagnosis of intraductal papilloma with atypia, excision is generally recommended to rule out a concurrent malignant neoplasm. For intraductal papillomas without atypia, however, recommendations for excision versus observation are variable. The aims of this study are to evaluate the rate of concurrent malignancies for intraductal papilloma diagnosed on core needle biopsy and to assess the long-term risk of developing cancer after the diagnosis of a papillary lesion...
August 27, 2017: Breast Journal
https://www.readbyqxmd.com/read/28815201/benign-papilloma-of-the-breast
#9
Moshe Sadofsky
The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040.
January 2017: Acad Pathol
https://www.readbyqxmd.com/read/28807342/accuracy-and-interobserver-agreement-of-retroareolar-frozen-sections-in-nipple-sparing-mastectomies
#10
David A Suarez-Zamora, Luis E Barrera-Herrera, Mauricio A Palau-Lazaro, Fabio Torres-Franco, Alejandro Orozco-Plazas, Lisette Barreto-Hauzeur, Paula A Rodriguez-Urrego
In the last decades, surgical treatment of breast cancer has enormously changed. As a result, nipple-sparing mastectomy (NSM) has evolved as an oncologically safe and cosmetic approach. NSM includes a subareolar frozen section to evaluate malignancy. We determined the accuracy of subareolar frozen section diagnosis, analyzed the discrepancy factor, and estimated the interobserver agreement of frozen section in NSM. A retrospective review of all NSMs at our institution from 2009 to 2015 was performed. Frozen sections were compared to the final diagnoses to analyze the accuracy of subareolar frozen sections...
August 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28766216/challenging-atypical-breast-lesions-including-flat-epithelial-atypia-radial-scar-and-intraductal-papilloma
#11
Jennifer M Racz, Jodi M Carter, Amy C Degnim
No abstract text is available yet for this article.
August 1, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28713607/primary-osteosarcoma-of-the-breast-arising-in-an-intraductal-papilloma
#12
Khalefa Ali Alghofaily, Musab Hamoud Almushayqih, Muhannad Faleh Alanazi, Abdullah Abdulrahman Bin Salamah, Halldor Benediktsson
INTRODUCTION: Primary osteosarcoma of the breast is extremely rare, and an osteosarcoma arising from an intraductal papilloma is exceptional. CASE PRESENTATION: A 72-year-old Saudi Arabian woman presented with a solid, bone-containing breast mass that was diagnosed as primary osteosarcoma of the breast on biopsy. She had a history of untreated intraductal papilloma. Treatment was completed with a modified mastectomy after excluding extramammary metastases. However, she subsequently developed multiple recurrent lesions at the same site...
2017: Case Reports in Radiology
https://www.readbyqxmd.com/read/28648934/molecular-alterations-in-lesions-of-anogenital-mammary-like-glands-and-their-mammary-counterparts-including-hidradenoma-papilliferum-intraductal-papilloma-fibroadenoma-and-phyllodes-tumor
#13
Anastasia M Konstantinova, Tomas Vanecek, Petr Martinek, Liubov Kyrpychova, Dominic V Spagnolo, Colin J R Stewart, Francesca Portelli, Michal Michal, Dmitry V Kazakov
Lesions affecting anogenital mammary-like glands (AGMLG) are histopathologically very similar to those seen in the breast but whether this morphological similarity is also reflected at the genetic level is unknown. To compare the underlying molecular mechanisms in lesions of AGMLG and their mammary counterparts, we analyzed the mutational profile of 16 anogenital neoplasms including 5 hidradenomas papilliferum (HP), 1 lesion with features of HP and fibroadenoma (FA), 7 FA, 3 phyllodes tumors (PhT)) and 18 analogous breast lesions (6 intraductal papillomas (IDP), 9 FA, and 3 PhT) by high-coverage next generation sequencing (NGS) using a panel comprising 50 cancer-related genes...
June 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28646723/vacuum-assisted-complete-excision-of-solid-intraductal-intracystic-masses-and-complex-cysts-is-follow-up-necessary
#14
Vanessa Quinn-Laurin, Jean-Charles Hogue, Sylvie Pinault, Nathalie Duchesne
INTRODUCTION: Management of complex cysts and benign intraductal/intracystic masses is controversial. The aim of this study was to determine if the complete removal of the complex cyst lesions with ultrasound-guided vacuum-assisted excision (US-VAE) is sufficient for their safe management when the histological diagnosis obtained at biopsy is benign. SUBJECTS AND METHODS: This is a single institution retrospective study performed on patients who underwent breast biopsy between April 2007 and September 2013...
June 21, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28635232/-analysis-of-the-clinicopathological-characteristics-and-prognosis-in-674-cases-of-breast-intraductal-papillary-tumor
#15
W Y Wang, X Wang, J D Gao, J Wang, J Q Liu, X Wang, D B Zhao
Objective: Breast intraductal papillary tumors are clinically common diseases derived from the ducts. The aim of this study is to investigate the clinicopathological characteristics of intraductal papillary tumors and risk factors for carcinogenesis. Methods: The clinicopathological data of 674 patients with breast intraductal papillary tumors, who underwent surgery in the National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences from January 2010 to July 2015, were retrospectively analyzed...
June 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28537481/investigation-of-methylenetetrahydrofolate-reductase-c677t-polymorphism-and-human-papilloma-virus-genotypes-in-iranian-breast-cancer
#16
Hanieh Rezaei, Hossein Rassi, Fahimeh Nemati Mansur
Breast cancer (BC) is the leading cause of death among Iranian women. Development of BC is a multistep process, arising from genetic changes such as methylenetetrahydrofolate reductase (MTHFR) polymorphism and infection with human papillomavirus (HPV). In this study, we investigated HPV genotypes associated with BCs and its relation with MTHFR C677T polymorphism for early detection of familial BCs. A total of 84 archival BC samples from Iran were collected. Verification of each cancer reported in a relative was sought through the pathology reports of the hospital records...
June 2017: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/28495003/viral-warts-human-papilloma-virus-as-a-potential-risk-for-breast-cancer-among-younger-females
#17
Suleman Atique, Chung-Ho Hsieh, Ruei-Ting Hsiao, Usman Iqbal, Phung Anh Alex Nguyen, Md Mohaimenul Islam, Yu-Chuan Jack Li, Chien-Yeh Hsu, Ting-Wu Chuang, Shabbir Syed-Abdul
INTRODUCTION: There have been several reports on the role of human papillomavirus (HPV) in the etiology of breast cancer. To our knowledge, this is first study to use disease-disease association data-mining approach to analyzing viral warts and breast cancer to be conducted in Taiwanese population. MATERIALS AND METHODS: We analyzed the Taiwan's National Health Insurance database (NHIDM data comprising of 23 million patient data) to examine the association between viral warts and female breast carcinoma...
June 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28482874/presence-of-human-papillomavirus-dna-in-breast-cancer-a-spanish-case-control-study
#18
Silvia Delgado-García, Juan-Carlos Martínez-Escoriza, Alfonso Alba, Tina-Aurora Martín-Bayón, Hortensia Ballester-Galiana, Gloria Peiró, Pablo Caballero, Jose Ponce-Lorenzo
BACKGROUND: Breast cancer is one of the most important neoplasia among women. It was recently suggested that biological agents could be the etiological cause, particularly Human Papilloma Virus (HPV). The aim of this study was to explore the presence of HPV DNA in a case-control study. METHODS: We performed our study including 251 cases (breast cancer) and 186 controls (benign breast tumors), using three different molecular techniques with PCR (GP5/GP6, CLART® and DIRECT FLOW CHIP®)...
May 8, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28438672/the-management-strategy-of-benign-solitary-intraductal-papilloma-on-breast-core-biopsy
#19
Dayoung Ko, Eunyoung Kang, So Yeon Park, Sun Mi Kim, Mijung Jang, Bo La Yun, Sumin Chae, Yerang Jang, Hye Jin Kim, Sung-Won Kim, Eun-Kyu Kim
BACKGROUND: Intraductal papilloma (IDP) is well-known as one of the common benign breast lesions requiring excision. However, treatment of IDP without atypia is controversial. The aim of our study was to determine the proper management of solitary IDP by core needle biopsy (CNB). PATIENTS AND METHODS: We retrospectively reviewed patients with solitary IDP confirmed by CNB from March 2003 to March 2015. We collected data about final pathology after excision, as well as clinical, histologic, and radiologic findings at initial diagnosis...
April 1, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28418338/diagnosis-of-nipple-discharge-value-of-magnetic-resonance-imaging-and-ultrasonography-in-comparison-with-ductoscopy
#20
Ravza Yılmaz, Ömer Bender, Fatma Çelik Yabul, Menduh Dursun, Mehtap Tunacı, Gülden Acunas
BACKGROUND: Pathologic nipple discharge, which is a common reason for referral to the breast imaging service, refers to spontaneous or bloody nipple discharge that arises from a single duct. The most common cause of nipple discharge is benign breast lesions, such as solitary intraductal papilloma and papillomatosis. Nevertheless, in rare cases, a malignant cause of nipple discharge can be found. AIMS: To study the diagnostic value of ultrasonography, magnetic resonance imaging, and ductoscopy in patients with pathologic nipple discharge, compare their efficacy, and investigate the importance of magnetic resonance imaging in the diagnosis of intraductal pathologies...
April 5, 2017: Balkan Medical Journal
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