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Breast papilloma

Kenichi Sakurai, Shigeru Fujisaki, Keita Adachi, Shuhei Suzuki, Yuki Masuo, Saki Nagashima, Yukiko Hara, Katsuhisa Enomoto, Tomohiro Hirano, Ryouichi Tomita, Kenji Gonda
We evaluated the clinical significance of indoleamine 2,3-dioxygenase(IDO)in intra-cystic tumors of the breast. IDO activitycan be measured byusing the tryptophan(Trp)/kynurenine(Kyn)ratio. Trp and Kyn were measured by high performance liquid chromatography(HPLC). We took liquid from 3 intra-cystic papilloma cases and 5 intra-cystic breast cancer cases. Then, we measured the Trp/Kyn ratio in these samples, and we evaluated the difference in the Trp/Kyn ratio between the papilloma group and the breast cancer group...
October 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
James Sutherland Lawson, Wendy K Glenn, Noel James Whitaker
High risk human papilloma viruses (HPVs) may have a causal role in some breast cancers. Case-control studies, conducted in many different countries, consistently indicate that HPVs are more frequently present in breast cancers as compared to benign breast and normal breast controls (odds ratio 4.02). The assessment of causality of HPVs in breast cancer is difficult because (i) the HPV viral load is extremely low, (ii) HPV infections are common but HPV associated breast cancers are uncommon, and (iii) HPV infections may precede the development of breast and other cancers by years or even decades...
2016: Frontiers in Oncology
Keisuke Goto, Daichi Maeda, Yukitsugu Kudo-Asabe, Takashi Hibiya, Akimasa Hayashi, Masashi Fukayama, Kenichi Ohashi, Akiteru Goto
AIMS: Hidradenoma papilliferum (HP) is a benign vulvar neoplasm that arises from anogenital mammary-like glands, and its morphology is similar to mammary intraductal papilloma. The aim of this study was to investigate oncogenic mutations involved in the tumourigenesis of HP. We focused specifically on PIK3CA and AKT1 mutations, which are both reported to be detected in 33% of mammary intraductal papillomas. METHODS: In total, seven HP cases were analysed. Clinicopathological analyses and immunohistochemistry for oestrogen receptor, p63, smooth muscle actin (SMA), p53 and β-catenin were performed...
October 14, 2016: Journal of Clinical Pathology
Jinhyuk Choi, Chungyeul Kim, Hye Seung Lee, Yoo Jin Choi, Ha Yeon Kim, Jinhwan Lee, Hyeyoon Chang, Aeree Kim
Background: Human papillomavirus (HPV) is a well-established oncogenic virus of cervical, anogenital, and oropharyngeal cancer. Various subtypes of HPV have been detected in 0% to 60% of breast cancers. The roles of HPV in the carcinogenesis of breast cancer remain controversial. This study was performed to determine the prevalence of HPV-positive breast cancer in Korean patients and to evaluate the possibility of carcinogenic effect of HPV on breast. Materials and Methods: Meta-analysis was performed in 22 case-control studies for HPV infection in breast cancer...
October 10, 2016: Journal of Pathology and Translational Medicine
Sang Yu Nam, Eun Young Ko, Boo-Kyung Han, Jung Hee Shin, Eun Sook Ko, Soo Yeon Hahn
PURPOSE: This study assessed the incidence and cancer rate of probably benign lesions detected on bilateral whole-breast screening ultrasound (US), which corresponded to US Breast Imaging Reporting and Data System (BI-RADS) category 3, and evaluated the proper management of those lesions. METHODS: This study was approved by the Institutional Review Board in our institution, which waived informed patient consent. We retrospectively reviewed US images of 1,666 patients who underwent bilateral whole-breast screening US as a supplemental screening test to negative screening mammography or screening US only...
September 2016: Journal of Breast Cancer
Melissa Brents, John Hancock
BACKGROUND: Ductal carcinoma in situ of the male breast is an unusual lesion and most often associated with invasive carcinoma. On rare occasions when the in situ component is present in pure form, histological grade is almost always low to intermediate. Imaging for these patients is difficult as gynecomastia is often present and can mask underlying calcifications or carcinoma. CASE REPORT: We report a case of pure high-grade ductal carcinoma in situ of the male breast in a patient with clear nipple discharge...
August 2016: Breast Care
Silvia Potenziani, Danielle Applebaum, Bhuvaneswari Krishnan, Carolina Gutiérrez, A Hafeez Diwan
Cowden Syndrome (CS) is an uncommon autosomal dominant multiorgan/system genodermatosis. It is characterized by the development of multiple hamartomas of endodermal, mesodermal and ectodermal origin, an increased lifetime risk of breast, thyroid, endometrial, and other cancers and an identifiable germline mutation. Mucocutaneous hamartomas are the most common lesions seen and mainly include facial trichilemmomas, oral mucosal papillomas, and benign acral keratoses. Herein, we report a case of a 63-year-old Caucasian male with a long-established diagnosis of CS and history of thyroid cancer, colonic polyps, and innumerable trichilemmomas, seborrheic keratoses, squamous papillomas, and non-melanoma skin cancers excised in the past...
September 28, 2016: Journal of Cutaneous Pathology
Ram Prasad, Santosh K Katiyar
Honokiol (C18H18O2) is a biphenolic natural product isolated from the bark and leaves of Magnolia plant spp. During the last decade or more, honokiol has been extensively studied for its beneficial effect against several diseases. Investigations have demonstrated that honokiol possesses anti-carcinogenic, anti-inflammatory, anti-oxidative, anti-angiogenic as well as inhibitory effect on malignant transformation of papillomas to carcinomas in vitro and in vivo animal models without any appreciable toxicity. Honokiol affects multiple signaling pathways, molecular and cellular targets including nuclear factor-κB (NF-κB), STAT3, epidermal growth factor receptor (EGFR), cell survival signaling, cell cycle, cyclooxygenase and other inflammatory mediators, etc...
2016: Advances in Experimental Medicine and Biology
Sung Mo Moon, Hae Kyoung Jung, Kyung Hee Ko, Youdong Kim, Kyong Sik Lee
OBJECTIVES: To determine how to manage clinically and mammographically occult benign papillary lesions diagnosed at ultrasound (US)-guided 14-gauge breast core needle biopsy (CNB) by evaluating their upgrade rates. METHODS: From our pathologic database of US-guided 14-gauge breast CNB, 69 benign papillomas and 9 atypical papillomas with available subsequent excisional findings (surgery or vacuum-assisted removal with additional US follow-up for ≥2 years) or US follow-up alone (≥2 years) were included in this study...
September 14, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Debjani Mallick, Aniruna Aniruna, Sonia Gon, Gayatri Ghosh
Malignant papillary neoplasms of the breast comprise a number of microscopically distinct lesions, where apocrine metaplasia is commonly found in papillomas compared to other papillary lesions including papillary carcinomas. However, association of apocrine metaplasia in papilloma with Ductal Carcinoma in Situ (DCIS) is not very well defined. The lesions with apocrine metaplasia are not only difficult to categories, but also there is controversy regarding their relative risk of subsequent carcinoma development...
2016: Iranian Journal of Pathology
Kyueng-Whan Min, Soo Kee Min, Mi Jung Kwon, Jinwon Seo, Hye-Rim Park, Lee Su Kim
No abstract text is available yet for this article.
August 4, 2016: Breast Journal
Anna-Lena Volckmar, Jonas Leichsenring, Christa Flechtenmacher, Nicole Pfarr, Udo Siebolts, Martina Kirchner, Jan Budczies, Michael Bockmayr, Kathrin Ridinger, Katja Lorenz, Esther Herpel, Aurelia Noske, Wilko Weichert, Frederick Klauschen, Peter Schirmacher, Roland Penzel, Volker Endris, Albrecht Stenzinger
Adenomas of the breast are rare benign tumors although single cases with malignant behavior have been reported. However, the genetic basis of these tumors is unknown. Employing targeted next generation sequencing of 50 cancer-related genes as well as Sanger sequencing, we profiled a cohort of 18 mammary adenomas comprising 9 ductal, 6 tubular, and 3 lactating adenoma. Missense mutations were detected in 8 of the 18 cases (44%). Specifically, five (56%) ductal adenomas and three (50%) tubular adenomas harbored mutated genes...
July 20, 2016: Genes, Chromosomes & Cancer
Fresia Pareja, Adriana D Corben, Sandra B Brennan, Melissa P Murray, Zenica L Bowser, Kiran Jakate, Christopher Sebastiano, Monica Morrow, Elizabeth A Morris, Edi Brogi
BACKGROUND: The surgical management of mammary intraductal papilloma without atypia (IDP) identified at core-needle biopsy (CNB) is controversial. This study assessed the rate of upgrade to carcinoma at surgical excision (EXC). METHODS: This study identified women with a CNB diagnosis of intraductal papilloma without atypia or carcinoma at a cancer center between 2003 and 2013. Radiologic-pathologic concordance was assessed for all cases, and discordant cases were excluded...
September 15, 2016: Cancer
Araya Boonyaleepan
BACKGROUND: Positron Emission Mammography (PEM) is a new modality in the investigation of breast cancer in Rajavithi Hospital, and its effectiveness has not yet been evaluated. OBJECTIVE: To study the effectiveness and characterization of breast images taken with PEM in Rajavithi Hospital. MATERIAL AND METHOD: This was a retrospective study in which data were collected and analyzed of patients who were investigated by PEM in Rajavithi Hospital between 18 September 2013 and 31 May 2014...
February 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Mette Søgaard, Dora K Farkas, Anne G Ording, Henrik T Sørensen, Deirdre P Cronin-Fenton
BACKGROUND: Human papillomavirus (HPV) infection may increase breast cancer (BC) risk. METHODS: To examine this, we used nationwide medical registries to identify all Danish women who underwent conisation to remove HPV-associated cervical precancerous lesions (n=87 782) from 1978 to 2013. We computed the absolute risk of BC and standardised incidence ratios (SIRs) and 95% confidence intervals (95% CIs) for breast cancer, based on national breast cancer incidence rates...
August 23, 2016: British Journal of Cancer
Ichiro Maeda, Shinya Tajima, Yasushi Ariizumi, Masatomo Doi, Akira Endo, Saeko Naruki, Masahiro Hoshikawa, Hirotaka Koizumi, Yoshihide Kanemaki, Takahiko Ueno, Koichiro Tsugawa, Masayuki Takagi
The differential diagnosis of epithelial proliferative disease using core needle biopsy (CNB) is problematic because it is difficult to differentiate between intraductal papilloma, ductal hyperplasia, ductal carcinoma in situ, and invasive ductal carcinoma. Many studies have reported that breast cancer lesions are positive for neuroendocrine (NE) markers, whereas only a small number of studies have reported immunopositivity for NE markers in normal mammary tissues or benign lesions. We asked whether NE factors could be used as markers of breast cancer...
July 2016: Pathology International
Mai Shibusawa, Ryohei Nakayama, Yuko Okanami, Yumi Kashikura, Nao Imai, Takashi Nakamura, Hiroko Kimura, Masako Yamashita, Noriko Hanamura, Tomoko Ogawa
PURPOSE: The purpose of this study was to evaluate the usefulness of a computer-aided diagnosis (CAD) scheme for improving the performance of clinicians to diagnose non-mass lesions appearing as hypoechoic areas on breast ultrasonographic images. METHODS: The database included 97 ultrasonographic images with hypoechoic areas: 48 benign cases [benign lesion with benign mammary tissue or fibrocystic disease (n = 20), fibroadenoma (n = 11), and intraductal papilloma (n = 17)] and 49 malignant cases [ductal carcinoma in situ (n = 17) and invasive ductal carcinoma (n = 32)]...
July 2016: Journal of Medical Ultrasonics
Sundaramoorthy Revathidevi, Mayakannan Manikandan, Arunagiri Kuha Deva Magendhra Rao, Vilvanathan Vinothkumar, Ganesan Arunkumar, Kottayasamy Seenivasagam Rajkumar, Rajendran Ramani, Ramamurthy Rajaraman, Chandrasekar Ajay, Arasambattu Kannan Munirajan
Breast cancer and cervical cancer are the leading causes of death in women worldwide as well as in India, whilst oral cancer is the top most common cancer among Asian especially in Indian men in terms of both incidence and mortality rate. Genetic factors determining the predisposition to cancer are being explored to identify the signature genetic variations associated with these cancers. Recently, a germline deletion polymorphism in APOBEC3 gene cluster which completely deletes APOBEC3B coding region has been studied for its association with cancer risk...
May 7, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Debatosh Majumdar, Mohammad Aminur Rahman, Zhuo Georgia Chen, Dong M Shin
Sexually transmitted oral cancer/head and neck cancer is increasing rapidly. Human papilloma virus (HPV) is playing a role in the pathogenesis of a subset of squamous cell carcinoma of head and neck (SCCHN). Paclitaxel is a widely used anticancer drug for breast, ovarian, testicular, cervical, non-small cell lung, head and neck cancer. However, it is water insoluble and orally inactive. We report the synthesis of water soluble nanosize conjugates of paclitaxel, branched PEG, and EGFR-targeting peptide by employing native chemical ligation...
2016: Frontiers in Bioscience (Elite Edition)
Amira Elbendary, Eric Cochran, Qiang Xie, Filamer Kabigting, Leanne Pereira, Dirk M Elston, Edward Heilman
Hidradenoma papilliferum is a benign cutaneous adnexal neoplasm, commonly occurring in the vulva and perianal region of adult women. It has characteristic histopathological features composed of anastomosing and branching tubules, lined by columnar cells, and a basal layer of myoepithelial cells. A 39-year-old woman was evaluated for 2 asymptomatic labial masses. The histopathological examination revealed a Bartholin's cyst and a hidradenoma papilliferum. The latter contains a distinct area of oncocytic/oxyphilic metaplasia...
June 2016: American Journal of Dermatopathology
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