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https://www.readbyqxmd.com/read/28328843/clinical-significance-of-interval-changes-in-breast-lesions-initially-categorized-as-probably-benign-on-breast-ultrasound
#1
Ja Yoon Jang, Sun Mi Kim, Jin Hwan Kim, Mijung Jang, Bo La Yun, Jong Yoon Lee, Soo Hyun Lee, Bohyoung Kim
The aims of this study were to determine the malignancy rate of probably benign lesions that show an interval change on follow-up ultrasound and to evaluate the differences seen on imaging between benign and malignant lesions initially categorized as probably benign but with interval change on follow-up breast ultrasound.We retrospectively reviewed 11,323 lesions from ultrasound-guided core-biopsies performed between June 2004 and December 2014 and identified 289 lesions (266 patients) with an interval change from probably benign (Breast Imaging Reporting and Data System [BI-RADS] category 3) in the previous 2 years...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28326600/prognostic-significance-of-tumour-infiltrating-b-lymphocytes-in-breast-ductal-carcinoma-in-situ
#2
I Miligy, P Mohan, A Gaber, M A Aleskandarany, C C Nolan, M Diez-Rodriguez, A Mukherjee, C Chapman, I O Ellis, A R Green, E A Rakha
BACKGROUND: Tumour infiltrating lymphocytes are an important component of the immune response to cancer and have a prognostic value in breast cancer. Although several studies have investigated the role of T-lymphocytes in breast cancer, the role of B lymphocytes (TIL-Bs) in Ductal carcinoma in situ (DCIS), remains uncertain. This study aimed to assess the role of TIL-Bs in DCIS. METHODS: 80 DCIS cases (36 pure DCIS and 44 mixed with invasive cancer) were immunohistochemically stained for B lineage markers CD19, CD20 and the plasma cell marker CD138...
March 22, 2017: Histopathology
https://www.readbyqxmd.com/read/28315967/relationship-of-breast-mri-to-recurrence-rates-in-patients-undergoing-breast-conservation-treatment
#3
Maureen V Hill, Julia L Beeman, Khushboo Jhala, Stefan D Holubar, Kari M Rosenkranz, Richard J Barth
PURPOSE: The effect of pre-operative MRI on the in-breast tumor recurrence rate (IBTR) of patients undergoing breast-conservation treatment (BCT) remains uncertain. We began to routinely perform pre-operative MRI in 2006. Our goal was to determine the effect of pre-operative MRI on IBTR. METHODS: Retrospective review of a prospective database of all patients undergoing BCT (n = 1396) from 2000 to 2010. IBTR were calculated using Kaplan-Meier estimates. RESULTS: 664 (47...
March 18, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28296665/papillomas-of-the-breast-factors-associated-with-underestimation
#4
Gabriela Boufelli, Marcelo A Giannotti, Carlos A Ruiz, Nestor de Barros, Luciano F Chala, Jonathan Y Maesaka, Rodrigo Goncalves, Bárbara H Bresciani, Paula Vianna, José M Soares, Edmund C Baracat, José R Filassi
The distinction between benign and malignant papilloma of the breast through percutaneous needle biopsy can be difficult because of limited samples; the underestimation rate can be up to 25%. The aim of this study is to identify clinical and histological factors associated with underestimation, invasive ductal carcinoma, or ductal in-situ carcinoma (DCIS) of the breast found in surgical specimens from papillary lesions. This may contribute toward selection of patients for a follow-up strategy without the need for surgical excision...
March 14, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28286675/ductal-breast-carcinoma-in-situ-mammographic-features-and-its-relation-to-prognosis-and-tumour-biology-in-a-population-based-cohort
#5
Wenjing Zhou, Thomas Sollie, Tibor Tot, Carl Blomqvist, Shahin Abdsaleh, Göran Liljegren, Fredrik Wärnberg
Casting-type calcifications and a histopathological picture with cancer-filled duct-like structures have been presented as breast cancer with neoductgenesis. We correlated mammographic features and histopathological neoductgenesis with prognosis in a DCIS cohort with long follow-up. Mammographic features were classified into seven groups according to Tabár. Histopathological neoductgenesis was defined by concentration of ducts, lymphocyte infiltration, and periductal fibrosis. Endpoints were ipsilateral (IBE) in situ and invasive events...
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/28285968/histologic-factors-predicting-invasion-in-patients-with-ductal-carcinoma-in-situ-dcis-in-the-preoperative-core-biopsy
#6
Areej M Al Nemer
BACKGROUND: It is desirable to decrease the underestimation rate of invasion in cases diagnosed as ductal carcinoma in situ (DCIS) in breast core needle biopsy (CNB) in order to determine the appropriate candidates for axillary staging. The objective of this study is to identify the predictors of invasion in histology. METHODS AND RESULTS: Consecutive 92 CNB's were retrospectively evaluated. The upstaging rate was 47.8% after surgery. Among all the evaluated parameters, high nuclear grade, single architectural pattern, marked periductal lymphocytic infiltration, partial myoepithelial loss and the presence of foci suspicious of microinvasion were the significant predictors of invasion (two tailed p values 0...
February 24, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28285212/glycogen-rich-clear-cell-carcinoma-grcc-of-the-breast-may-not-have-a-poor-prognosis
#7
Muna M Baslaim, Enaam M Junainah, Hadeel H Ahmad, Anmar F Semilan, Ahmed O Al-Ghamdi, Noora O Rahimuddin, Budoor A Salman
INTRODUCTION: Glycogen Rich Clear Cell Carcinoma (GRCC) is a rare variant of breast carcinomas and believed to be linked with a poor prognosis. CASE SUMMARY: We are presenting a 60-year-old Saudi lady with a 2cm GRCC carcinoma associated with clear cell ductal carcinoma in situ (DCIS) and no axillary lymph node involvement. The tumor was Estrogen and Progesterone receptors (ER & PR) positive and HER 2-neu negative. She underwent mastectomy with sentinel lymph node biopsy followed by hormonal therapy...
February 27, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28281788/comparison-of-mammography-ultrasound-and-mri-in-size-assessment-of-ductal-carcinoma-in-situ-with-histopathologic-correlation
#8
Soo Heui Baek, Woo Jung Choi, Joo Hee Cha, Hak Hee Kim, Hee Jung Shin, Eun Young Chae
Background The ability to accurately assess tumor size in ductal carcinoma in situ (DCIS) is an important clinical issue when selecting the appropriate treatment plan. Purpose To compare the accuracy of using mammography, ultrasound (US), and magnetic resonance imaging (MRI) to assess DCIS tumor size based on imaging and histopathological findings. Material and Methods Fifty-six patients with DCIS were included. Mammography, US, and MRI were reviewed, and the accuracy of the measured tumor sizes were compared with the imaging and histopathological parameters...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28279887/evaluation-of-percutaneous-vacuum-assisted-intact-specimen-breast-biopsy-device-for-ultrasound-visualized-breast-lesions-upstage-rates-and-long-term-follow-up-for-high-risk-lesions-and-dcis
#9
Cathy L Graham
OBJECTIVE: Percutaneous core biopsy of ultrasound visualized breast lesions is standard for diagnosis. Large gauge vacuum-assisted core needles have improved accuracy; but a significant underestimation of malignancy remains. The Intact(R) device was assessed for upstaging and subsequent malignancy at the biopsy site. METHODS: 469 consecutive ultrasound visualized breast lesions, < 2.0 cm in size, BIRADS 4 or 5, biopsied with Intact(R) Breast Lesion Excision System, between July 2007 and August 2014, were reviewed...
March 6, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28274272/the-method-of-detection-of-ductal-carcinoma-in-situ-has-no-therapeutic-implications-results-of-a-population-based-cohort-study
#10
Lotte E Elshof, Michael Schaapveld, Emiel J Rutgers, Marjanka K Schmidt, Linda de Munck, Flora E van Leeuwen, Jelle Wesseling
BACKGROUND: Population screening with mammography has resulted in increased detection of ductal carcinoma in situ (DCIS). The aim of this population-based cohort study was to assess whether the method of detection should be considered when determining prognosis and treatment in women with DCIS. METHODS: This study includes 7042 women aged 49-75 years, who were surgically treated for primary DCIS between 1989 and 2004 in the Netherlands. We calculated cumulative incidences of ipsilateral and contralateral invasive breast cancer and all-cause mortality among women with screen-detected, interval, or non-screening-related DCIS, and assessed the association between method of detection and these outcomes, using multivariable Cox regression analyses...
March 9, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28273747/histogram-analysis-of-volume-based-apparent-diffusion-coefficient-in-breast-cancer
#11
Ga Eun Park, Sung Hun Kim, Eun Jeong Kim, Bong Joo Kang, Mi Sun Park
Background Breast cancer is a heterogeneous disease. Recent studies showed that apparent diffusion coefficient (ADC) values have various association with tumor aggressiveness and prognosis. Purpose To evaluate the value of histogram analysis of ADC values obtained from the whole tumor volume in invasive ductal cancer (IDC) and ductal carcinoma in situ (DCIS). Material and Methods This retrospective study included 201 patients with confirmed DCIS (n = 37) and IDC (n = 164). The IDC group was divided into two groups based on the presence of a DCIS component: IDC-DCIS (n = 76) and pure IDC (n = 88)...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28265306/screening-with-magnetic-resonance-imaging-mammography-and-ultrasound-in-women-at-average-and-intermediate-risk-of-breast-cancer
#12
Tomasz Huzarski, Barbara Górecka-Szyld, Jowita Huzarska, Grażyna Psut-Muszyńska, Grażyna Wilk, Robert Sibilski, Cezary Cybulski, Beata Kozak-Klonowska, Monika Siołek, Ewa Kilar, Dorota Czudowska, Hanna Janiszewska, Dariusz Godlewski, Andrzej Mackiewicz, Joanna Jarkiewicz-Tretyn, Jadwiga Szabo-Moskal, Jacek Gronwald, Jan Lubiński, Steven A Narod
BACKGROUND: The addition of MRI to mammography and ultrasound for breast cancer screening has been shown to improve screening sensitivity for high risk women, but there is little data to date for women at average or intermediate risk. METHODS: Two thousand nine hundred and ninety-five women, aged 40 to 65 years with no previous history of breast cancer were enrolled in a screening program, which consisted of two rounds of MRI, ultrasound and mammography, one year apart...
2017: Hereditary Cancer in Clinical Practice
https://www.readbyqxmd.com/read/28262606/adjuvant-therapy-in-patients-with-ductal-carcinoma-in-situ-of-the-breast-the-pandora-s-box
#13
REVIEW
Matteo Lazzeroni, Barbara K Dunn, Giancarlo Pruneri, Barbara Alicja Jereczek-Fossa, Roberto Orecchia, Bernardo Bonanni, Andrea DeCensi
Most patients with ductal carcinoma in situ of the breast (DCIS) are eligible for breast conservation treatment. The key management decision is whether to add radiotherapy and/or endocrine therapy to minimize the risk of a subsequent recurrence. Recent analyses indicating a lack of benefit in terms of breast cancer-associated mortality have suggested that more conservative approaches, omitting adjuvant therapy or even surgery, may be advisable in selected patients. These mortality observations are directly influenced by widespread use of mammographic screening which has opened a Pandora's box of subclinical DCIS and early invasive lesions...
February 11, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28257326/radioactive-seed-localization-or-wire-guided-localization-of-nonpalpable-invasive-and-in-situ-breast-cancer-a-randomized-multicenter-open-label-trial
#14
Linnea Langhans, Tove F Tvedskov, Thomas L Klausen, Maj-Britt Jensen, Maj-Lis Talman, Ilse Vejborg, Cemil Benian, Anne Roslind, Jonas Hermansen, Peter S Oturai, Niels Bentzon, Niels Kroman
OBJECTIVE: To compare the rate of positive resection margins between radioactive seed localization (RSL) and wire-guided localization (WGL) after breast conserving surgery (BCS). BACKGROUND: WGL is the current standard for localization of nonpalpable breast lesions in BCS, but there are several difficulties related to the method. METHODS: From January 1, 2014 to February 4, 2016, patients with nonpalpable invasive breast cancer or DCIS visible on ultrasound were enrolled in this randomized, multicenter, open-label clinical trial, and randomly assigned to RSL or WGL...
March 2, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28247220/what-quality-of-life-issues-do-women-with-ductal-carcinoma-in-situ-dcis-consider-important-when-making-treatment-decisions
#15
Rebecca Mercieca-Bebber, Madeleine T King, Miriam M Boxer, Andrew Spillane, Zoë E Winters, Phyllis N Butow, Joan McPherson, Claudia Rutherford
PURPOSE: To explore quality-of-life (QOL) issues considered important when deciding on treatment for ductal carcinoma in situ (DCIS). METHODS: Breast Cancer Network of Australia members diagnosed with DCIS in the past 5 years (self-identified) participated in an online survey (Sep-Nov 2015). From a list of 74 QOL issues, participants selected all issues they experienced during DCIS diagnosis, treatment or recovery, then the issues they felt important to making a DCIS treatment decision, and completed the Health Literacy Questionnaire (HLQ)...
February 28, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28242086/ultrasound-image-classification-of-ductal-carcinoma-in-situ-dcis-of-the-breast-analysis-of-705-dcis-lesions
#16
Takanori Watanabe, Takuhiro Yamaguchi, Hiroko Tsunoda, Setsuko Kaoku, Eriko Tohno, Hidemitsu Yasuda, Kanako Ban, Koichi Hirokaga, Kumiko Tanaka, Takeshi Umemoto, Toshitaka Okuno, Yasuhisa Fujimoto, Shuichi Nakatani, Jun Ito, Ei Ueno
The Japan Association of Breast and Thyroid Sonology (JABTS) proposed, in 2003, a conceptual classification system for non-mass abnormalities to be applied in addition to the conventional concept of masses, to facilitate detecting ductal carcinoma in situ (DCIS) lesions. The aim of this study was to confirm the utility of this system and to clarify the distribution of these findings in DCIS lesions. Data on 705 surgically treated DCIS lesions from 16 institutions in Japan were retrospectively reviewed. All 705 DCIS lesions could be classified according to the JABTS classification system...
February 24, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28240012/do-breast-cancer-risk-factors-affect-the-survival-of-breast-cancer-patients-in-southern-sri-lanka
#17
H H Peiris, L K B Mudduwa, N I Thalagala, K A P W Jayatilaka
Background: Breast cancer continues to be a major cause of morbidity among women in Sri Lanka. Possible effects of etiological risk factors on breast cancer specific survival (BCSS) of the disease is not clear.This study was designed to explore the impact of breast cancer risk factors on the BCSS of patients in Southern Sri Lanka. Method: This retro-prospective study included all breast cancer patients who had sought immunohistochemistry services at our unit from May 2006 to December 2012. A pre-tested, interviewer-administered questionnaire was used to gather information on risk factors...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28239564/cancer-stem-cells-and-early-stage-basal-like-breast-cancer
#18
Pang-Kuo Lo, Benjamin Wolfson, Qun Zhou
Ductal carcinoma in situ (DCIS) is a category of early stage, non-invasive breast tumor defined by the intraductal proliferation of malignant breast epithelial cells. DCIS is a heterogeneous disease composed of multiple molecular subtypes including luminal, HER2 and basal-like types, which are characterized by immunohistochemical analyses and gene expression profiling. Following surgical and radiation therapies, patients with luminal-type, estrogen receptor-positive DCIS breast tumors can benefit from adjuvant endocrine-based treatment...
May 10, 2016: World Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28238520/precision-surgery-and-avoiding-over-treatment
#19
REVIEW
A Hosseini, A L Khoury, L J Esserman
Over-diagnosis and over-treatment are consequences of greater awareness about breast cancer, more intensive screening, and the resultant identification of more cases of breast cancer that are low or ultralow risk. This area represents an important opportunity to optimize the delivery of appropriate targeted therapy for breast cancer patients. Despite the evolution of breast cancer care over the last few decades and our ability to tailor treatment to biology, a one-size fits all approach is still prevalent in the local and regional management of and screening for breast cancer, failing to reflect the unique biology and tumor characteristics of each patient...
February 11, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28235801/the-scaffolding-protein-nherf1-regulates-the-stability-and-activity-of-the-tyrosine-kinase-her2
#20
Jaekwang Jeong, Joshua N Vanhouten, Wonnam Kim, Pamela Dann, Catherine Sullivan, Jungmin Choi, W Bruce Sneddon, Peter A Friedman, John J Wysolmerski
Unlike other ErbB family members, ErbB2/HER2/Neu (HER2) is not internalized but remains on the cell surface when activated. This allows for prolonged signaling and contributes to its transforming ability. Previous studies have shown that the calcium pump, PMCA2, interacts with HER2 within membrane protrusions and is required for the retention of HER2 on the cell surface. In this study, we knocked down NHERF1 expression in breast cancer cells lines and examined whether the scaffolding protein, NHERF1, interacts with PMCA2 and HER2...
February 24, 2017: Journal of Biological Chemistry
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