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https://www.readbyqxmd.com/read/28938000/podoplanin-increases-the-migration-of-human-fibroblasts-and-affects-the-endothelial-cell-network-formation-a-possible-role-for-cancer-associated-fibroblasts-in-breast-cancer-progression
#1
Jaroslaw Suchanski, Anna Tejchman, Maciej Zacharski, Aleksandra Piotrowska, Jedrzej Grzegrzolka, Grzegorz Chodaczek, Katarzyna Nowinska, Janusz Rys, Piotr Dziegiel, Claudine Kieda, Maciej Ugorski
In our previous studies we showed that in breast cancer podoplanin-positive cancer-associated fibroblasts correlated positively with tumor size, grade of malignancy, lymph node metastasis, lymphovascular invasion and poor patients' outcome. Therefore, the present study was undertaken to assess if podoplanin expressed by fibroblasts can affect malignancy-associated properties of breast cancer cells. Human fibroblastic cell lines (MSU1.1 and Hs 578Bst) overexpressing podoplanin and control fibroblasts were co-cultured with breast cancer MDA-MB-231 and MCF7 cells and the impact of podoplanin expressed by fibroblasts on migration and invasiveness of breast cancer cells were studied in vitro...
2017: PloS One
https://www.readbyqxmd.com/read/28932627/addition-of-anti-estrogen-therapy-to-anti-her2-dendritic-cell-vaccination-improves-regional-nodal-immune-response-and-pathologic-complete-response-rate-in-patients-with-er-pos-her2-pos-early-breast-cancer
#2
Lea Lowenfeld, Salman Zaheer, Crystal Oechsle, Megan Fracol, Jashodeep Datta, Shuwen Xu, Elizabeth Fitzpatrick, Robert E Roses, Carla S Fisher, Elizabeth S McDonald, Paul J Zhang, Angela DeMichele, Rosemarie Mick, Gary K Koski, Brian J Czerniecki
HER2-directed therapies are less effective in patients with ER(pos) compared to ER(neg) breast cancer, possibly reflecting bidirectional activation between HER2 and estrogen signaling pathways. We investigated dual blockade using anti-HER2 vaccination and anti-estrogen therapy in HER2(pos)/ER(pos) early breast cancer patients. In pre-clinical studies of HER2(pos) breast cancer cell lines, ER(pos) cells were partially resistant to CD4(+) Th1 cytokine-induced metabolic suppression compared with ER(neg) cells...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28929550/characteristics-and-clinical-outcomes-of-pleomorphic-lobular-carcinoma-in-situ-of-the-breast
#3
Carolina E Fasola, Jie Jane Chen, Kristin C Jensen, Kimberly H Allison, Kathleen C Horst
Pleomorphic lobular carcinoma in situ (PLCIS) of the breast is a rare variant of lobular carcinoma in situ (LCIS). We reviewed 78 cases of PLCIS diagnosed at our institution from 1998 to 2012. Among all cases, 47 (60%) were associated with invasive carcinoma and/or ductal carcinoma in situ (DCIS) after final surgical excision. Of the 20 cases with PLCIS alone on core needle biopsy (CNB), 6 (30%) were upgraded to invasive carcinoma or DCIS after final surgical excision. Our findings support a recommendation for complete surgical excision of PLCIS when diagnosed on CNB...
September 19, 2017: Breast Journal
https://www.readbyqxmd.com/read/28928852/dcis-margins-and-breast-conservation-md-anderson-cancer-center-multidisciplinary-practice-guidelines-and-outcomes
#4
REVIEW
Henry M Kuerer, Benjamin D Smith, Mariana Chavez-MacGregor, Constance Albarracin, Carlos H Barcenas, Lumarie Santiago, Mary E Edgerton, Gaiane M Rauch, Sharon H Giordano, Aysegul Sahin, Savitri Krishnamurthy, Wendy Woodward, Debasish Tripathy, Wei T Yang, Kelly K Hunt
Recent published guidelines suggest that adequate margins for DCIS should be ≥ 2 mm after breast conserving surgery followed by radiotherapy (RT). Many groups now use this guideline as an absolute indication for additional surgery. This article describes detailed multidisciplinary practices including extensive preoperative/intraoperative pathologic/histologic image-guided assessment of margins, offering some patients with small low/intermediate grade DCIS no RT, the use/magnitude of radiation boost tailoring to margin width, and endocrine therapy for ER-positive DCIS...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28925613/surgery-versus-monitoring-and-endocrine-therapy-for-low-risk-dcis-the-comet-trial
#5
Linda M Youngwirth, Judy C Boughey, E Shelley Hwang
No abstract text is available yet for this article.
January 2017: Bulletin of the American College of Surgeons
https://www.readbyqxmd.com/read/28918560/margin-free-excision-of-small-solid-breast-carcinomas-using-the-intact-breast-lesion-excision-system-%C3%A2-is-it-feasible
#6
Ioannis K Papapanagiotou, Dimitra Koulocheri, Vasileios Kalles, Paraskevi Liakou, Nikolaos V Michalopoulos, Wasim Al-Harethee, Georgia Georgiou, Maria Matiatou, Afroditi Nonni, Anastasia Pazaiti, Georgios E Theodoropoulos, Evangelos Menenakos, Georgios C Zografos
BACKGROUND: The Breast Lesion Excision System(®) (BLES(®)) is a stereotactic vacuum-assisted breast biopsy device that utilizes radiofrequency in order to excise non-palpable mammographic lesions for pathologic diagnosis. The purpose of this study was to evaluate the efficacy of BLES(®) in performing complete, margin-free excisions of small solid carcinomas. METHODS: Our retrospective study of prospectively enrolled patients included 50 cases of non-palpable, BIRADS ≥ 4, solid by means of mammography and sonography, lesions...
September 16, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28917445/margin-width-and-local-recurrence-after-breast-conserving-surgery-for-ductal-carcinoma-in-situ
#7
Gregory E Ekatah, Arran K Turnbull, Laura M Arthur, Jeremy Thomas, Christine Dodds, J Michael Dixon
INTRODUCTION: Ductal Carcinoma in situ (DCIS) represents 5% of symptomatic and 20-30% of screen detected cancers. Breast conserving surgery (BCS) ± radiotherapy is performed in over 70% of women with DCIS. What constitutes an adequate margin for BCS remains unclear. METHODS: A single institution follow up study has been conducted of 466 patients with pure DCIS treated by BCS between 2000 and 2010 of whom 292 received whole breast radiotherapy and 167 did not...
September 4, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28914599/ductal-carcinoma-in-situ-quantitative-preoperative-breast-mr-imaging-features-associated-with-recurrence-after-treatment
#8
Jing Luo, Brian S Johnston, Averi E Kitsch, Daniel S Hippe, Larissa A Korde, Sara Javid, Janie M Lee, Sue Peacock, Constance D Lehman, Savannah C Partridge, Habib Rahbar
Purpose To investigate whether specific imaging features on breast magnetic resonance (MR) images are associated with ductal carcinoma in situ (DCIS) recurrence risk after definitive treatment. Materials and Methods Patients with DCIS who underwent preoperative dynamic contrast material-enhanced (DCE) MR imaging between 2004 and 2014 with ipsilateral recurrence more than 6 months after definitive surgical treatment were retrospectively identified. For each patient, a control subject with DCIS that did not recur was identified and matched on the basis of clinical, histopathologic, and treatment features known to affect recurrence risk...
September 14, 2017: Radiology
https://www.readbyqxmd.com/read/28902360/expression-of-periostin-in-breast-cancer-cells
#9
Katarzyna Ratajczak-Wielgomas, Jedrzej Grzegrzolka, Aleksandra Piotrowska, Rafal Matkowski, Andrzej Wojnar, Janusz Rys, Maciej Ugorski, Piotr Dziegiel
Periostin (POSTN) is a protein involved in multiple processes important for cancer development, both at the stage of cancer initiation and progression, as well as metastasis. The aim of this study was to determine the expression of POSTN in the cells of non-invasive ductal breast carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) and to correlate it with clinicopathological data. Immunohistochemical studies (IHC) were conducted on 21 cases of fibrocystic breast change (FC), 44 cases of DCIS and 92 cases of IDC...
October 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28898125/diagnostic-utility-of-mri-after-negative-or-inconclusive-mammography-for-the-evaluation-of-pathologic-nipple-discharge
#10
Manisha Bahl, Michele A Gadd, Constance D Lehman
OBJECTIVE: The purpose of this study is to determine the diagnostic utility of MRI after negative or inconclusive mammography for the evaluation of pathologic nipple discharge. MATERIALS AND METHODS: We conducted a retrospective review of breast MRI examinations from January 1, 2006, through December 31, 2015, that were performed after negative or inconclusive mammography for the evaluation of nipple discharge. Clinical notes, imaging findings, and pathology outcomes were reviewed...
September 12, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28894982/severe-depression-more-common-in-patients-with-ductal-carcinoma-in-situ-than-early-stage-invasive-breast-cancer-patients
#11
M L Gregorowitsch, H J G D van den Bongard, D A Young-Afat, J P Pignol, C H van Gils, A M May, H M Verkooijen
PURPOSE: Ductal carcinoma in situ (DCIS) is associated with an excellent prognosis; historical studies have shown similar levels of psychological distress in patients with DCIS and with early-stage invasive breast cancer (early-IBC). It is suggested that these results might have led to better patient education about prognosis after DCIS. This study reports the current levels of anxiety, depression, and health-related quality of life (HRQoL) in DCIS and early-IBC patients. METHODS: DCIS (n = 89) and early-IBC patients, T1-2N0, (n = 361) were selected from the UMBRELLA breast cancer cohort...
September 11, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28894698/paradigm-shift-toward-reducing-overtreatment-of-ductal-carcinoma-in-situ-of-breast
#12
REVIEW
Yasuaki Sagara, Wong Julia, Mehra Golshan, Masakazu Toi
The prevalence of ductal carcinoma in situ (DCIS) of the breast has increased substantially after the introduction of breast cancer screening programs, although the clinical effects of early DCIS detection and treatment remain unclear. The standard treatment for DCIS has involved local breast-conserving surgery (BCS) followed by radiotherapy (RT) or total mastectomy with/without endocrine therapy, and the choice of local treatment is not usually based on clinicopathologic or biological factors. However, we have investigated the effectiveness of local treatment using breast surgery and RT using Surveillance, Epidemiology, and End Results data, and found that the effectiveness of breast surgery was modified by the nuclear grade...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28890755/architectural-patterns-for-differential-diagnosis-of-proliferative-breast-lesions-from-histopathological-images
#13
L Nguyen, A B Tosun, J L Fine, D L Taylor, S C Chennubhotla
The differential diagnosis of proliferative breast lesions, benign usual ductal hyperplasia (UDH) versus malignant ductal carcinoma in situ (DCIS) is challenging. This involves a pathologist examining histopathologic sections of a biopsy using a light microscope, evaluating tissue structures for their architecture or size, and assessing individual cell nuclei for their morphology. Imposing diagnostic boundaries on features that otherwise exist on a continuum going from benign to atypia to malignant is a challenge...
April 2017: Proceedings of the IEEE International Symposium on Biomedical Imaging: from Nano to Macro
https://www.readbyqxmd.com/read/28885232/comparison-of-proliferation-markers-ki67-and-phosphohistone-h3-phh3-in-breast-ductal-carcinoma-in-situ
#14
Dustin E Bosch, Mark R Kilgore, Rodney A Schmidt, Paul E Swanson, Mara H Rendi, Oliver H Chang
Proliferative index is a prognostic feature of invasive ductal carcinoma of the breast, and has more recently emerged as a predictor of ductal carcinoma in situ (DCIS) local recurrence and progression when used in combination with other predictive markers. Ki67 is the most commonly used immunohistochemical marker of proliferative index. However, high interobserver and interlaboratory variability has been reported, in part due to differences in staining methodologies, positivity thresholds, and approaches to quantification...
September 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28882419/carcinoma-in-situ-of-the-breast-in-new-south-wales-australia-current-status-and-trends-over-the-last-40-year
#15
Gemma Jacklyn, Stephen Morrell, Kevin McGeechan, Nehmat Houssami, Les Irwig, Nirmala Pathmanathan, Alexandra Barratt
BACKGROUND: The incidence of non-invasive breast cancer has increased substantially over time. We aim to describe temporal trends in the incidence of carcinoma in situ of the breast in New South Wales (NSW), Australia. METHODS: Descriptive study of trends in the incidence of ductal carcinoma in situ (DCIS) and lobular carcinoma in situ (LCIS) in women who received a diagnosis from 1972 to 2012, recorded in the NSW Cancer Registry. RESULTS: Carcinoma in situ as a proportion of all breast cancer was 0...
September 4, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28879558/second-opinion-strategies-in-breast-pathology-a-decision-analysis-addressing-over-treatment-under-treatment-and-care-costs
#16
Anna N A Tosteson, Qian Yang, Heidi D Nelson, Gary Longton, Samir S Soneji, Margaret Pepe, Berta Geller, Patricia A Carney, Tracy Onega, Kimberly H Allison, Joann G Elmore, Donald L Weaver
PURPOSE: To estimate the potential near-term population impact of alternative second opinion breast biopsy pathology interpretation strategies. METHODS: Decision analysis examining 12-month outcomes of breast biopsy for nine breast pathology interpretation strategies in the U.S. health system. Diagnoses of 115 practicing pathologists in the Breast Pathology Study were compared to reference-standard-consensus diagnoses with and without second opinions. Interpretation strategies were defined by whether a second opinion was sought universally or selectively (e...
September 6, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28876551/breast-ductal-carcinoma-in-situ-in-an-unscreened-population-presentation-diagnosis-and-management-at-a-single-tertiary-centre
#17
M Mutebi, H Simonds
BACKGROUND: To determine the clinical presentation of patients presenting with isolated ductal carcinoma in situ at a single tertiary center in the Cape Town, South Africa. To review the diagnostic techniques most commonly used and the primary surgery performed for these patients. METHOD: We performed a retrospective folder review of patients diagnosed with DCIS over a period from Jan 2005 to Dec 2012, at the Combined Breast Cancer Clinic at Groote Schuur Hospital...
March 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28870935/detection-of-ductal-carcinoma-in-situ-by-ultrasound-and-mammography-size-dependent-inaccuracy
#18
Christian Eichler, Sharareh Abrar, Julian Puppe, Mariam Arndt, Ralf Ohlinger, Markus Hahn, Mathias Warm
BACKGROUND: Retrospective analysis of breast cancer imaging methods is a common tool for evaluating the effectiveness of ultrasound and mammography regarding ductal carcinoma in situ (DCIS). No large number subpopulation of pure DCIS has been reported. It is however known that mammography and ultrasound underestimate tumor dimension with increasing tumor size. We aimed to quantify this discrepancy. MATERIALS AND METHODS: This retrospective analysis reviewed the ultrasound and mammography data from 173 patients with DCIS at the University of Cologne - Department of Gynecology and Obstetrics between the years 2007 and 2010...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28870933/clinicopathological-features-of-ductal-carcinoma-in-situ-from-18-f-fdg-pet-findings
#19
Takaaki Fujii, Keiko Yanai, Shoko Tokuda, Yuko Nakazawa, Sasagu Kurozumi, Sayaka Obayashi, Reina Yajima, Tomoko Hirakata, Hiroyuki Kuwano
AIM: The presence of ductal carcinoma in situ (DCIS) can increase the risk of developing an invasive ductal carcinoma (IDC), but it is difficult to predict what will occur if a DCIS is left untreated. We reported the usefulness of (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) for DCIS, and that the presence of FDG uptake in the tumor could be considered a predictor of invasive potential in patients with DCIS. In this study, we retrospectively evaluated the clinicopathological features of DCIS by using FDG-PET findings, and we evaluated the possibility of using FDG-PET in DCIS cases as a biomarker of which lesions will go on to become invasive...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28865259/current-margin-practice-and-effect-on-re-excision-rates-following-the-publication-of-the-sso-astro-consensus-and-abs-consensus-guidelines-a-national-prospective-study-of-2858-women-undergoing-breast-conserving-therapy-in-the-uk-and-ireland
#20
Sarah Shuk-Kay Tang, Sarantos Kaptanis, James B Haddow, Giuseppina Mondani, Beatrix Elsberger, Marios Konstantinos Tasoulis, Christine Obondo, Neil Johns, Wisam Ismail, Asim Syed, Panayioti Kissias, Mary Venn, Souganthy Sundaramoorthy, Gareth Irwin, Amtul S Sami, Dalia Elfadl, Alice Baggaley, Dionysios Dennis Remoundos, Fiona Langlands, Petros Charalampoudis, Zoe Barber, Werbena L S Hamilton-Burke, Ayesha Khan, Chiara Sirianni, Louise Anne-Marie Grant Merker, Sunita Saha, Risha Arun Lane, Sharat Chopra, Sophie Dupré, Aiden T Manning, Edward R St John, Aya Musbahi, Nokwanda Dlamini, Caitlin L McArdle, Chloe Wright, James O Murphy, Ravi Aggarwal, Matei Dordea, Karen Bosch, Donna Egbeare, Hisham Osman, Salim Tayeh, Faraz Razi, Javeria Iqbal, Serena F C Ledwidge, Vanessa Albert
INTRODUCTION: There is variation in margin policy for breast conserving therapy (BCT) in the UK and Ireland. In response to the Society of Surgical Oncology and American Society for Radiation Oncology (SSO-ASTRO) margin consensus ('no ink on tumour' for invasive and 2 mm for ductal carcinoma in situ [DCIS]) and the Association of Breast Surgery (ABS) consensus (1 mm for invasive and DCIS), we report on current margin practice and unit infrastructure in the UK and Ireland and describe how these factors impact on re-excision rates...
August 29, 2017: European Journal of Cancer
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