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https://www.readbyqxmd.com/read/29793212/should-we-excise-are-there-any-clinical-or-histologic-features-that-predict-upgrade-in-papillomas-incidental-or-non-incidental
#1
Michael Zaleski, Yun An Chen, Alison L Chetlen, Julie Mack, Liyan Xu, Daleela G Dodge, Dipti M Karamchandani
The clinical decision to excise intraductal papilloma (IDP) without atypia diagnosed on biopsy remains controversial. We sought to establish clinical and histologic predictors (if any) which may predict upgrade in IDP. 296 biopsies (in 278 women) with histologic diagnosis of IDP without atypia were retrospectively identified and placed into Incidental (no corresponding imaging correlate), or Non-incidental (positive imaging correlate) groups. 253/296 (85.5%) cases were non-incidental, and 43/296 (14.5%) were incidental...
May 11, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29792742/screening-mammography-findings-from-one-standard-projection-only-in-the-era-of-full-field-digital-mammography-and-digital-breast-tomosynthesis
#2
Ethan O Cohen, Hilda H Tso, Kanchan A Phalak, Ray C Mayo, Jessica W T Leung
OBJECTIVE: The purpose of this article is to compare outcomes of findings seen on one view only from screening full-field digital mammography (FFDM) and FFDM plus digital breast tomosynthesis (DBT). MATERIALS AND METHODS: A retrospective review was performed of 103,070 consecutive screening mammograms obtained from February 2011 through June 2014 at two community-based breast centers. Recalled findings prospectively seen on one view only were analyzed. Pearson chi-square test and Fisher exact test were performed, and 95% CIs were determined...
May 24, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29789230/impact-of-second-opinion-interpretation-of-breast-imaging-studies-in-patients-not-currently-diagnosed-with-breast-cancer
#3
Lauren Q Chang Sen, Ray C Mayo, Michele D Lesslie, Wei T Yang, Jessica W T Leung
PURPOSE: To study the impact of second-opinion interpretation of breast imaging studies submitted from outside facilities to a tertiary cancer center. MATERIALS AND METHODS: A retrospective database review was conducted of second-opinion interpretations rendered at our institution from January 1, 2010, to June 30, 2014, on studies from patients who did not have a concurrent breast cancer diagnosis. A total of 2,253 patients were included. RESULTS: In 800 of 2,253 patients (35...
May 19, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29788740/multiparametric-mri-analysis-of-morphologico-functional-features-of-dcis-correlation-with-grade-of-nuclear-atypia
#4
V Lehotska, K Rauova, L Vanovcanova
The aim was to analyze morphologico-functional characteristics of ductal carcinoma in situ (DCIS) in breast MRI to assess signs correlating with the degree of nuclear atypia. From 636 malignant lesions, 114 were DCIS (17.92%): 44 cases of high-grade (38.60%), 37 intermediate (32.45%), 33 low-grade (28.95%). MRI characteristics - T2 signal intensity (SI), shape, margins, contrast enhancement, peripheral/ductal enhancement, kinetic curve, presence of restriction of diffusion were correlated with the nuclear grade of DCIS...
March 14, 2018: Neoplasma
https://www.readbyqxmd.com/read/29786772/upstaging-to-invasive-ductal-carcinoma-after-mastectomy-for-ductal-carcinoma-in-situ-predictive-factors-and-role-of-sentinel-lymph-node-biopsy
#5
Yusuke Watanabe, Keisei Anan, Michiyo Saimura, Kenichiro Koga, Minoru Fujino, Mari Mine, Sadafumi Tamiya, Kazuyoshi Nishihara, Toru Nakano, Shoshu Mitsuyama
BACKGROUND: The aim of this study was to investigate preoperative factors associated with ductal carcinoma in situ (DCIS) upstaged to invasive ductal carcinoma (IDC) and sentinel lymph node (SLN) status in patients who underwent mastectomy for a preoperative diagnosis of DCIS. METHODS: The medical records of 220 patients who underwent mastectomy for a preoperative diagnosis of DCIS were retrospectively reviewed. RESULTS: Fifty-one (22.6%) of 226 lesions were upgraded to IDC after mastectomy...
May 21, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29759643/oncoplastic-breast-surgery-for-the-management-of-ductal-carcinoma-in-situ-dcis-is-it-oncologically-safe-a-retrospective-cohort-analysis
#6
Francesca De Lorenzi, Julien Di Bella, Patrick Maisonneuve, Nicole Rotmensz, Giovanni Corso, Roberto Orecchia, Marco Colleoni, Giovanni Mazzarol, Mario Rietjens, Pietro Loschi, Stefano Marcelli, Paolo Veronesi, Viviana Galimberti
BACKGROUND: Few data exist in literature regarding oncoplastic surgery (ONC) and ductal carcinoma in situ (DCIS). The role of ONC in the treatment of DCIS has not been elucidated yet: no case-control study has yet been published on the issue and no long-term oncologic results are reported. METHODS: Using the European Institute of Oncology (IEO) institutional breast cancer data base we investigated the oncologic safety of ONC for DCIS comparing a consecutive series of 44 patients who have underwent ONC followed by external irradiation for DCIS (Group A-study group) with 375 patients who received conservation alone followed by external irradiation for DCIS (Group B control group) in the same period...
April 24, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29753007/evaluating-agreement-histological-features-and-relevance-of-separating-pleomorphic-and-florid-lobular-carcinoma-in-situ-subtypes
#7
Kamaljeet Singh, Cherie Paquette, Elizabeth T Kalife, Yihong Wang, Shamlal Mangray, M Ruhul Quddus Md MPhil, Margaret M Steinhoff
Morphological variants of lobular carcinoma in situ (LCIS) include classical- (CLCIS), pleomorphic- (PLCIS) and florid-type (FLCIS). Treatment guidelines suggest managing PLCIS and FLCIS like ductal carcinoma in situ (DCIS); therefore accurate identification of LCIS subtypes is critical. However significance of separating PLCIS from FLCIS is not clear. Also inter-observer agreement in identifying LCIS subtypes, using contemporary criteria, is not known. We aimed to evaluate inter-observer agreement amongst breast pathologists in diagnosing LCIS subtypes and use the agreement data to justify LCIS classification for management purposes...
May 9, 2018: Human Pathology
https://www.readbyqxmd.com/read/29731404/tumor-resection-margin-definitions-in-breast-conserving-surgery-systematic-review-and-meta-analysis-of-the-current-literature
#8
REVIEW
Susan G Brouwer de Koning, Marie-Jeanne T F D Vrancken Peeters, Katarzyna Jóźwiak, Patrick A Bhairosing, Theo J M Ruers
Worldwide, various guidelines recommend what constitutes an adequate margin of excision for invasive breast cancer or for ductal carcinoma-in-situ (DCIS). We evaluated the use of different tumor resection margin guidelines and investigated their impact on positive margin rates (PMR) and reoperation rates (RR). Thirteen guidelines reporting on the extent of a positive margin were reviewed along with 31 studies, published between 2011 and 2016, reporting on a well-defined PMR. Studies were categorized according to the margin definition...
April 13, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29730730/risk-of-ischemic-heart-disease-after-radiotherapy-for-ductal-carcinoma-in-situ
#9
C Wadsten, A-K Wennstig, H Garmo, Greger Nilsson, Carl Blomqvist, Lars Holmberg, Irma Fredriksson, F Wärnberg, M Sund
PURPOSE: The use of adjuvant radiotherapy (RT) in the management of ductal carcinoma in situ (DCIS) is increasing. Left-sided breast irradiation may involve exposure of the heart to ionising radiation, increasing the risk of ischemic heart disease (IHD). We examined the incidence of IHD in a population-based cohort of women with DCIS. METHODS: The Breast Cancer DataBase Sweden (BCBase) cohort includes women registered with invasive and in situ breast cancers 1992-2012 and age-matched women without a history of breast cancer...
May 5, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29730304/assessing-the-effectiveness-of-interventions-to-support-patient-decision-making-about-breast-reconstruction-a-systematic-review
#10
REVIEW
Nicole Paraskeva, Ella Guest, Helena Lewis-Smith, Diana Harcourt
BACKGROUND: Decision making about breast reconstruction (BR) following a diagnosis of breast cancer, Ductal Carcinoma in Situ (DCIS), or to reduce future breast cancer risk, is difficult and complex. This paper systematically reviews interventions aiming to support patients facing the option of BR, and assesses their effectiveness in improving a range of patient outcomes. METHODS: Ten databases were searched for articles published up to October 2017 that evaluated interventions to support patient decision making about BR within controlled trials...
May 3, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29722170/clinicopathological-characteristics-and-survival-outcomes-in-paget-disease-a-seer-population-based-study
#11
Yang Zhao, He-Fen Sun, Meng-Ting Chen, Shui-Ping Gao, Liang-Dong Li, Hong-Lin Jiang, Wei Jin
The objective of this study was to investigate the clinicopathological characteristics and survival outcomes of Paget disease (PD), Paget disease concomitant infiltrating duct carcinoma (PD-IDC), and Paget disease concomitant intraductal carcinoma (PD-DCIS). We identified 501,631 female patients from 2000 to 2013 in the Surveillance, Epidemiology, and End Results (SEER) database. These identified patients included patients with PD (n = 469), patients with PD-IDC (n = 1832), and patients with PD-DCIS (n = 1130) and infiltrating ductal carcinoma (IDC) (n = 498,076)...
May 2, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29719429/prescribing-practices-of-endocrine-therapy-for-ductal-carcinoma-in-situ-in-british-columbia
#12
A T Chaudhry, T A Koulis, C Speers, R A Olson
Purpose: The mainstay of treatment for ductal carcinoma in situ (dcis) involves surgery in the form of mastectomy or lumpectomy. Inconsistency in the use of endocrine therapy (et) for dcis is evident worldwide. We sought to assess the variation in et prescribing for patients with dcis across a population-based radiotherapy (rt) program and to identify variables that predict its use. Methods: Data from a breast cancer database were obtained for women diagnosed with dcis in British Columbia from 2009 to 2014...
April 2018: Current Oncology
https://www.readbyqxmd.com/read/29717421/treatment-intensity-differences-after-early-stage-breast-cancer-esbc-diagnosis-depending-on-participation-in-a-screening-program
#13
Kenneth Elder, Carolyn Nickson, Melinda Pattanasri, Samuel Cooke, Dorothy Machalek, Allison Rose, Arlene Mou, John Paxton Collins, Allan Park, Richard De Boer, Claire Phillips, Vicki Pridmore, Helen Farrugia, G Bruce Mann
BACKGROUND: While population mammographic screening identifies early-stage breast cancers (ESBCs; ductal carcinoma in situ [DCIS] and invasive disease stages 1-3A), commentaries suggest that harms from overdiagnosis and overtreatment may outweigh the benefits. Apparent benefits to patients with screen-detected cancers may be due to selection bias from exclusion of interval cancers (ICs). Treatment intensity is rarely discussed, with an assumption that all ESBCs are treated similarly. We hypothesized that women diagnosed while in a screening program would receive less-intense treatment than those never or not recently screened (NRS)...
May 1, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29712688/intraoperative-resection-guidance-with-photoacoustic-and-fluorescence-molecular-imaging-using-an-anti-b7-h3-antibody-indocyanine-green-dual-contrast-agent
#14
Katheryne E Wilson, Sunitha V Bachawal, Juergen K Willmann
PURPOSE: Breast cancer often requires surgical treatment including breast-conserving surgical resection. However, with current post-surgical histological margin analysis, one-quarter of breast cancer patients undergo re-excision to achieve negative margins corresponding to decreased local recurrence and better outcomes. Therefore, a method with high resolution and specificity for intraoperative margin assessment is needed. EXPERIMENTAL DESIGN: First, quantitative immunofluorescence staining of B7-H3 expression was assessed in four pathological stages of breast cancer progression of the MMTV-PyMT transgenic murine model...
April 30, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29712602/ability-of-intraoperative-pathologic-analysis-of-ductal-carcinoma-in-situ-to-guide-selective-use-of-sentinel-lymph-node-surgery
#15
Brittany L Murphy, Alexandra B Gonzalez, Michael G Keeney, Beiyun Chen, Amy L Conners, Tara L Henrichsen, Amy C Degnim, William S Harmsen, Judy C Boughey, Tina J Hieken, Elizabeth B Habermann, James W Jakub
For patients with ductal carcinoma In Situ (DCIS), sentinel lymph node (SLN) surgery is generally reserved for patients at high risk of being upstaged to invasive disease. The use of frozen section (FS) pathologic analysis of the primary tumor may allow for selective surgical nodal staging within one procedure. We sought to define the reliability of FS for detection of upstaging. Eight hundred and twenty-seven patients were identified with DCIS on core needle biopsy that underwent 834 operations at our institution between January 2004 and October 2014...
April 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29709458/prognostic-significance-of-clinicopathologic-features-in-patients-with-breast-ductal-carcinoma-in-situ-who-received-breast-conserving-surgery
#16
Sung-Hsin Kuo, Chiao Lo, Yu-Hsuan Chen, Huang-Chun Lien, Wen-Hung Kuo, Ming-Yang Wang, Yi-Hsuan Lee, Chiun-Sheng Huang
PURPOSE: To identify whether a certain group of breast ductal carcinoma-in-situ (DCIS) patients can be treated with breast-conserving surgery (BCS) alone; to analyze the clinicopathologic features of DCIS and tamoxifen administration in patients treated with BCS who developed ipsilateral breast tumor recurrence (IBTR). PATIENTS AND METHODS: Data for 375 women with breast DCIS who underwent BCS at our institute between June 2003 and October 2010 were analyzed. The patients were divided into different categories according to the recurrence risk predicted using the California/Van Nuys Prognostic Index (USC/VNPI) score (4-6, 7-9, and 10-12), Eastern Cooperative Oncology Group (ECOG) E5194 criteria, or combined risk features with USC/VNPI score and ECOG E5194 criteria...
April 10, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29708782/mri-clinical-examination-and-mammography-for-preoperative-assessment-of-residual-disease-and-pathologic-complete-response-after-neoadjuvant-chemotherapy-for-breast-cancer-acrin-6657-trial
#17
John R Scheel, Eunhee Kim, Savannah C Partridge, Constance D Lehman, Mark A Rosen, Wanda K Bernreuter, Etta D Pisano, Helga S Marques, Elizabeth A Morris, Paul T Weatherall, Sandra M Polin, Gillian M Newstead, Laura J Esserman, Mitchell D Schnall, Nola M Hylton
OBJECTIVE: The objective of our study was to determine the accuracy of preoperative measurements for detecting pathologic complete response (CR) and assessing residual disease after neoadjuvant chemotherapy (NACT) in patients with locally advanced breast cancer. SUBJECTS AND METHODS: The American College of Radiology Imaging Network 6657 Trial prospectively enrolled women with ≥ 3 cm invasive breast cancer receiving NACT. Preoperative measurements of residual disease included longest diameter by mammography, MRI, and clinical examination and functional volume on MRI...
April 30, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29705287/a-population-based-audit-of-surgical-practice-and-outcomes-of-oncoplastic-breast-conservations-in-scotland-an-analysis-of-589-patients
#18
Laszlo Romics, E Jane Macaskill, Teresa Fernandez, Louise Simpson, Elizabeth Morrow, Vassilis Pitsinis, Sian Tovey, Matthew Barber, Yazan Masannat, Sheila Stallard, Eva Weiler-Mithoff, Andrew Malyon, James Mansell, Esther J Campbell, Julie Doughty, J Michael Dixon
INTRODUCTION: Current evidence for oncoplastic breast conservation (OBC) is based on single institutional series. Therefore, we carried out a population-based audit of OBC practice and outcomes in Scotland. METHODS: A predefined database of patients treated with OBC was completed retrospectively in all breast units practicing OBC in Scotland. RESULTS: 589 patients were included from 11 units. Patients were diagnosed between September 2005 and March 2017...
April 13, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29698706/the-effect-of-size-and-polymer-architecture-of-doxorubicin-poly-ethylene-glycol-conjugate-nanocarriers-on-breast-duct-retention-potency-and-toxicity
#19
Zichao Gu, Dayuan Gao, Firas Al-Zubaydi, Shike Li, Yashveer Singh, Kristia Rivera, Jennifer Holloway, Zoltan Szekely, Susan Love, Patrick J Sinko
Although systemic administration of chemotherapeutic agents is routinely used for treating invasive breast cancer, the only therapeutic options for ductal carcinoma in situ (DCIS) are surgery and radiation. Treating DCIS by delivering drugs locally to the affected milk duct offers significant advantages over systemic administration, including reduced systemic and breast toxicities, as well as a greatly reduced need for surgery and radiation. In this study, mammary gland retention and toxicity of intraductally administered poly(ethylene) glycol-doxorubicin (PEG-DOX) polymeric conjugate nanocarriers of varying molecular sizes and architectures were investigated...
April 23, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29687205/the-impact-of-hormonal-contraceptives-on-breast-cancer-pathology
#20
Jesse A Dorchak, Sifat Maria, Joseph L Guarinoni, Anette Duensing, Stella Somiari, Jane Cavanaugh, Brenda Deyarmin, Hai Hu, Joji Iida, Craig D Shriver, Paula A Witt-Enderby
This retrospective case series study, using data obtained through questionnaires and histopathological diagnoses from 656 patients enrolled in the Department of Defense (DoD) Clinical Breast Care Project (CBCP), evaluated associations between hormonal contraceptive use and breast cancer pathology including benign breast pathologies. Three combination hormonal contraceptive agents (COCs) Lo Ovral (LO), Ortho Novum (ON), and Ortho Tri-Cyclen (OTC) were evaluated as they represented the most commonly used hormonal contraceptives in our cohort...
April 23, 2018: Hormones & Cancer
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