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Ahmad Ainurofiq, Syaiful Choiri, Muhamad Ali Azhari, Chaterin Romauli Siagian, Bambang Budi Suryadi, Fea Prihapsara, Sholichah Rohmani
Purpose: The aim of this research was to formulate and develop an orally disintegrating tablet (ODT) that incorporated a MEL/β-CD complex, using a quality by design (QbD) approach to enhance solubility and drug release. Methods: Multiple regression linear analysis was conducted to develop the kneading process and ODT formulation. Mixing time and amount of solvent were used as independent variables in kneading process optimisation, while the superdisintegrants were used to obtain the desired formulation. Fourier transform infrared spectroscopy and differential scanning calorimetry were performed for complex characterization...
September 2016: Advanced Pharmaceutical Bulletin
Xuemin Cheng, Yikang Yang, Qun Hao
The thermal environment is an important factor in the design of optical systems. This study investigated the thermal analysis technology of optical systems for navigation guidance and control in supersonic aircraft by developing empirical equations for the front temperature gradient and rear thermal diffusion distance, and for basic factors such as flying parameters and the structure of the optical system. Finite element analysis (FEA) was used to study the relationship between flying and front dome parameters and the system temperature field...
October 17, 2016: Sensors
Jiang Zhu, Li Qi, Yusi Miao, Teng Ma, Cuixia Dai, Yueqiao Qu, Youmin He, Yiwei Gao, Qifa Zhou, Zhongping Chen
Elastography provides a powerful tool for histopathological identification and clinical diagnosis based on information from tissue stiffness. Benefiting from high resolution, three-dimensional (3D), and noninvasive optical coherence tomography (OCT), optical micro-elastography has the ability to determine elastic properties with a resolution of ~10 μm in a 3D specimen. The shear wave velocity measurement can be used to quantify the elastic modulus. However, in current methods, shear waves are measured near the surface with an interference of surface waves...
October 20, 2016: Scientific Reports
Yuta Shimura, Yuji Sato, Noboru Kitagawa, Miyuki Omori
BACKGROUND: Proper implant placement is very important for long-term implant stability. Recently, numerous biomechanical studies have been conducted to clarify the relationship between implant placement and peri-implant stress. The placement of multiple implants in the edentulous posterior mandible has been studied by geometric analysis, three-dimensional finite element analysis (FEA), model experimentation, etc. Offset placement is a technique that reduces peri-implant load. However, few studies have used multiple analyses to clarify the value of the offset placement under identical conditions...
December 2016: Int J Implant Dent
Miyuki Omori, Yuji Sato, Noboru Kitagawa, Yuta Shimura, Manabu Ito
BACKGROUND: Three-dimensional finite element analysis (FEA) is effective in analyzing stress distributions around dental implants. However, FEA of living tissue involves many conditions, and the structures and behaviors are complex; thus, it is difficult to ensure the validity of the results. To verify reproducibility and validity, we embedded implants in experimental models and constructed FEA models; implant displacements were compared under various loading conditions. METHODS: Implants were embedded in the molar regions of artificial mandibles to fabricate three experimental models...
December 2015: Int J Implant Dent
Sandra L Gómez, Yesid Montoya, Nora L Garcia, Ana L Virgen, Javier E Botero
The aim of this study was to compare frictional resistance among conventional, passive and active selfligating brackets using Finite Elements Analysis (FEA). Seventynine (79) slide tests were performed by combining an upper first bicuspid conventional bracket, 0.018" stainless steel wires and 0.010" ligature by means of an INSTRON 3345 load system to obtain average maximum static frictional resistance (MSFR). This value was compared to the FR (frictional resistance) obtained by simulation of a slide of the same combination by FEA following conventional bracket modeling by means of Computer Aided Design (CAD)...
September 2016: Acta Odontológica Latinoamericana: AOL
Lixia Fan, Shaopeng Pei, X Lucas Lu, Liyun Wang
The transport of fluid, nutrients, and signaling molecules in the bone lacunar-canalicular system (LCS) is critical for osteocyte survival and function. We have applied the fluorescence recovery after photobleaching (FRAP) approach to quantify load-induced fluid and solute transport in the LCS in situ, but the measurements were limited to cortical regions 30-50 μm underneath the periosteum due to the constrains of laser penetration. With this work, we aimed to expand our understanding of load-induced fluid and solute transport in both trabecular and cortical bone using a multiscaled image-based finite element analysis (FEA) approach...
2016: Bone Research
C Fives, C J O'Neill, R Murphy, M A Corrigan, M J O'Sullivan, L Feeley, M W Bennett, F O'Connell, T J Browne
BACKGROUND: The diagnosis and management of lobular neoplasia (LN) including lobular carcinoma in situ (LCIS) and atypical lobular hyperplasia (ALH) remains controversial. Current management options after a core needle biopsy (CNB) with lobular neoplasia (LN) incorporating both ALH and LCIS include excision biopsy or careful clinical and radiologic follow up. METHODS: A retrospective analysis of the surgical database at Cork University Hospital was performed to identify all core needle biopsies from January 1st 2010 to 31st December 2013 with a diagnosis of FA who subsequently underwent surgical excision biopsy...
October 3, 2016: Breast: Official Journal of the European Society of Mastology
Wo-Jan Tseng, Ching-Kong Chao, Chun-Chin Wang, Jinn Lin
INTRODUCTION: Notch sensitivity may compromise titanium-alloy plate fatigue strength. However, no studies providing head-to-head comparisons of stainless-steel or titanium-alloy locking plates exist. MATERIALS AND METHODS: Custom-designed identically structured locking plates were made from stainless steel (F138 and F1314) or titanium alloy. Three screw-hole designs were compared: threaded screw-holes with angle edges (type I); threaded screw-holes with chamfered edges (type II); and non-threaded screw-holes with chamfered edges (type III)...
September 30, 2016: Injury
Soo-Jin Kang, Hojin Ha, June-Goo Lee, Seung-Bong Han, Gary S Mintz, Jihoon Kweon, Mineok Chang, Jae-Hyung Roh, Pil Hyung Lee, Sung-Han Yoon, Jung-Min Ahn, Duk-Woo Park, Seung-Whan Lee, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park, Young-Hak Kim
BACKGROUND AND AIMS: We aimed to determine whether finite element analysis (FEA)-derived plaque structural stress (PSS) analysis can predict serial changes in atheroma volume, type, and tissue composition within a fibroatheroma-containing target segment. METHODS: Overall, 210 patients (210 untreated coronary artery lesions) underwent serial (baseline and 12-month follow-up) grayscale- and virtual histology (VH)-intravascular ultrasound (IVUS). Baseline PSS was assessed at the minimal lumen and at the maximum necrotic core (NC) sites...
September 30, 2016: Atherosclerosis
Dieter H Pahr, Philippe K Zysset
Beyond bone mineral density (BMD), bone quality designates the mechanical integrity of bone tissue. In vivo images based on X-ray attenuation, such as CT reconstructions, provide size, shape, and local BMD distribution and may be exploited as input for finite element analysis (FEA) to assess bone fragility. Further key input parameters of FEA are the material properties of bone tissue. This review discusses the main determinants of bone mechanical properties and emphasizes the added value, as well as the important assumptions underlying finite element analysis...
October 6, 2016: Current Osteoporosis Reports
Flávia Zardo Trindade, Luiz Felipe Valandro, Niek de Jager, Marco Antônio Bottino, Cornelis Johannes Kleverlaan
PURPOSE: To determine the elastic properties of five ceramic systems with different compositions (lithium disilicate vs. feldspathic ceramics) and processing methods and compare the stress distribution in premolars in the interface with inlays made with these systems loaded with the maximum normal bite force (665 N) using 3D finite element analysis (FEA). MATERIALS AND METHODS: The elastic properties of five ceramic restoration materials (IPS e.max Press, IPS e...
October 3, 2016: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
Zhichao Fan, Yihui Zhang, Qiang Ma, Fan Zhang, Haoran Fu, Keh-Chih Hwang, Yonggang Huang
Lithographically defined interconnects with filamentary, serpentine configurations have been widely used in various forms of stretchable electronic devices, owing to the ultra-high stretchability that can be achieved and the relative simple geometry that facilitates the design and fabrication. Theoretical models of serpentine interconnects developed previously for predicting the performance of stretchability were mainly based on the theory of infinitesimal deformation. This assumption, however, does not hold for the interconnects that undergo large levels of deformations before the structural failure...
August 2016: International Journal of Solids and Structures
Tahl I Frenkel, Kalsea J Koss, Bonny Donzella, Kristin A Frenn, Connie Lamm, Nathan A Fox, Megan R Gunnar
Individual differences in the propensity for left versus right frontal electroencephalogram (EEG) asymmetry may underlie differences in approach/withdrawal tendencies and mental health deficits. Growing evidence suggests that early life adversity may shape brain development and contribute to the emergence of mental health problems. The present study examined frontal EEG asymmetry (FEA) following the transition to family care in children adopted internationally from institutional care settings between 15 and 36 months of age (N = 82; 46 female, 36 male)...
September 29, 2016: Journal of Abnormal Child Psychology
Maki Matsuzaki, Yasunori Ayukawa, Nobuo Sakai, Tatsuya Matsuzaki, Yasuyuki Matsushita, Kiyoshi Koyano
A number of finite element analyses (FEAs) for the dental implant were performed without regard for preload and with all interfaces 'fixed-bonded'. The purpose of this study was comparing the stress distributions between the conventional FEA model with all contacting interfaces 'fixed-bonded' (bonded model) and the model with the interfaces of the components in 'contact' with friction simulated as a preloaded implant (contact model). We further verified the accuracy of the result of the FEA using model experiment...
September 28, 2016: Computer Methods in Biomechanics and Biomedical Engineering
Boris Dousteyssier, Jérôme Molimard, Chafiaa Hamitouche, Woo Suck Han, Eric Stindel
OBJECTIVE: With cartilage physiopathology, knee stability and therefore the subsequent loadings on ligaments have a strong impact in the development of knee osteoarthritis. To understand this phenomenon, authors are proposing different knee models. Most of them are without any flexion, some have been introduced by controlling actively muscular groups. In this case, the forces used to achieve the flexion may not be physiological, and the pressure on the articulation can be questioned. We propose a mixed approach, both using medical imaging (MRI, EOS X-ray system) and force platform in conjunction with a finite element model...
September 2016: Annals of Physical and Rehabilitation Medicine
Shu-Fen Chuang, Pin-Sheng Huang, Terry Yuan-Fang Chen, Lo-Hao Huang, Ko-Chih Su, Chi-Han Chang
OBJECTIVES: To investigate the effects of light curing protocols on the shrinkage behaviors, contraction stress, and microleakage in composite restorations by an experimental-numerical hybrid analysis. METHODS: Three groups of human molars were collected to receive different light-curing protocols: vertical or oblique curing at regular intensity, and vertical curing at reduced intensity. For each tooth, the composite fillings were consecutively placed under unbonded and bonded states, and their shrinkage behaviors were examined with a digital image correlation (DIC) technique...
September 23, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
Kanehiro Matsuyama, Yasuhiro Ishidou, Yong-Ming Guo, Hironori Kakoi, Takao Setoguchi, Satoshi Nagano, Ichiro Kawamura, Shingo Maeda, Setsuro Komiya
BACKGROUND: Femoral bone remodeling in response to stress shielding induces periprosthetic bone loss. Computerized finite element analysis (FEA) is employed to demonstrate differences in initial stress distribution. However, FEA is often performed without considering the precise sites at which the stem was fixed. We determined whether FEA reflects mid-term radiological examination exactly as predicted following long-term stress shielding. METHODS: Femur-stem fixation sites were evaluated radiologically according to the location of spot welds in two anatomical cementless stem designs...
2016: BMC Musculoskeletal Disorders
Sean McCafferty, Garrett Lim, William Duncan, Eniko Enikov, Jim Schwiegerling
PURPOSE: We evaluate solutions for an applanating surface modification to the Goldmann tonometer prism, which substantially negates the errors due to patient variability in biomechanics. METHODS: A modified Goldmann or correcting applanation tonometry surface (CATS) prism is presented which was optimized to minimize the intraocular pressure (IOP) error due to corneal thickness, stiffness, curvature, and tear film. Mathematical modeling with finite element analysis (FEA) and manometric IOP referenced cadaver eyes were used to optimize and validate the design...
September 2016: Translational Vision Science & Technology
W S Enns-Bray, O Ariza, S Gilchrist, R P Widmer Soyka, P J Vogt, H Palsson, S K Boyd, P Guy, P A Cripton, S J Ferguson, B Helgason
Finite element analysis (FEA) of bones scanned with Quantitative Computed Tomography (QCT) can improve early detection of osteoporosis. The accuracy of these models partially depends on the assigned material properties, but anisotropy of the trabecular bone cannot be fully captured due to insufficient resolution of QCT. The inclusion of anisotropy measured from high resolution peripheral QCT (HR-pQCT) could potentially improve QCT-based FEA of the femur, although no improvements have yet been demonstrated in previous experimental studies...
September 15, 2016: Medical Engineering & Physics
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