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https://www.readbyqxmd.com/read/27892536/investigation-of-cell-substrate-adhesion-properties-of-living-chondrocyte-by-measuring-adhesive-shear-force-and-detachment-using-afm-and-inverse-fea
#1
Trung Dung Nguyen, YuanTong Gu
It is well-known that cell adhesion is important in many biological processes such as cell migration and proliferation. A better understanding of the cell adhesion process will shed insight into these cellular biological responses as well as cell adhesion-related diseases treatment. However, there is little research which has attempted to investigate the process of cell adhesion and its mechanism. Thus, this paper aims to study the time-dependent adhesion properties of single living chondrocytes using an advanced coupled experimental-numerical approach...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27890355/the-effects-of-cavity-margin-angles-and-bolus-stiffness-on-the-mechanical-behavior-of-indirect-resin-composite-class-ii-restorations
#2
Pietro Ausiello, Stefano Ciaramella, Franklin Garcia-Godoy, Antonio Gloria, Antonio Lanzotti, Saverio Maietta, Massimo Martorelli
OBJECTIVE: To study the influence of the different class II mesio-occlusal-distal (MOD) cavity shape on the stress and strain distributions in adhesive indirect restorations, using numerical finite element analysis (FEA). To investigate the relationship between restored teeth failure and stiffness of food, three values of Young's modulus were used for the food. METHODS: A 3D model of a sound lower molar and three class II MOD cavities with different shape were created...
November 24, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27885998/bi-ventricular-finite-element-model-of-right-ventricle-overload-in-the-healthy-rat-heart
#3
Fulufhelo Masithulela
BACKGROUND: The recognition of RV overpressure is critical to human life, as this may signify morbidity and mortality. Right ventricle (RV) dysfunction is understood to have an impact on the performance of the left ventricle (LV), but the mechanisms remain poorly understood. It is understood that ventricular compliance has the ability to affect cardiac performance. In this study, a bi-ventricular model of the rat heart was used in preference to other, single-ventricle models. Finite element analysis (FEA) of the bi-ventricular model provides important information on the function of the healthy heart...
November 25, 2016: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/27866696/equivalent-young-s-modulus-of-composite-resin-for-simulation-of-stress-during-dental-restoration
#4
Jung-Hoon Park, Nak-Sam Choi
OBJECTIVES: For shrinkage stress simulation in dental restoration, the elastic properties of composite resins should be acquired beforehand. This study proposes a formula to measure the equivalent Young's modulus of a composite resin through a calculation scheme of the shrinkage stress in dental restoration. METHODS: Two types of composite resins remarkably different in the polymerization shrinkage strain were used for experimental verification: the methacrylate-type (Clearfil AP-X) and the silorane-type (Filtek P90)...
November 17, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27834413/can-degradation-of-adhesive-interfaces-due-to-water-storage-affect-stress-distributions-a-finite-element-stress-analysis-study
#5
Sema Belli, Oğuz Eraslan, Gürcan Eskitaşcıoğlu
PURPOSE: The aim of this finite-element stress analysis (FEA) was to determine the effect of degradation due to water storage on stress distributions in root-filled premolar models restored with composite using either a self-etch (SE) or an etch-and-rinse (E&R) adhesive. MATERIALS AND METHODS: Four premolar FEA models including root filling, MOD cavity, and composite restorations were created. The cavities were assumed to be treated by SE or E&R adhesives and stored in water for 18 months...
November 10, 2016: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/27833729/the-prosthetic-influence-and-biomechanics-on-peri-implant-strain-a-systematic-literature-review-of-finite-element-studies
#6
REVIEW
Julius Maminskas, Algirdas Puisys, Ritva Kuoppala, Aune Raustia, Gintaras Juodzbalys
OBJECTIVES: To systematically review risks of mechanical impact on peri-implant strain and prosthetic influence on stability across finite element studies. MATERIAL AND METHODS: An online literature search was performed on MEDLINE and EMBASE databases published between 2011 and 2016. Following keywords tiered screening and selection of the title, abstract and full-text were performed. Studies of finite element analysis (FEA) were considered for inclusion that were written in English and revealed stress concentrations or strain at peri-implant bone level...
July 2016: Journal of Oral & Maxillofacial Research
https://www.readbyqxmd.com/read/27832842/flat-epithelial-atypia-on-core-needle-biopsy-must-we-surgically-excise
#7
A A Acott, A T Mancino
: Breast flat epithelial atypia (FEA) often coexists with more aggressive pathology and excision is currently recommended when diagnosed by core needle biopsy (CNB). Recent studies suggest isolated FEA has a low association with carcinoma and may warrant close surveillance. A radiology database containing 2189 breast CNB was reviewed for isolated FEA or FEA in combination with atypical pathology. 79 patients had FEA. There were 48/79 with isolated FEA and 31/79 concomitant FEA with ADH, ALH, or LCIS...
October 29, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27831866/a-biomechanical-modeling-guided-cbct-estimation-technique
#8
You Zhang, Joubin Nasehi Tehrani, Jing Wang
Two-dimensional-to-three-dimensional (2D-3D) deformation has emerged as a new technique to estimate cone-beam computed tomography (CBCT) images. The technique is based on deforming a prior high-quality 3D CT/CBCT image to form a new CBCT image, guided by limited-view 2D projections. The accuracy of this intensity-based technique, however, is often limited in low-contrast image regions with subtle intensity differences. The solved deformation vector fields (DVFs) can also be biomechanically unrealistic. To address these problems, we have developed a biomechanical modeling guided CBCT estimation technique (Bio-CBCT-est) by combining 2D-3D deformation with finite element analysis (FEA)-based biomechanical modeling of anatomical structures...
November 1, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27829624/finite-element-analysis-on-nanomechanical-sensing-of-cellular-forces
#9
Gaku Imamura, Kota Shiba, Genki Yoshikawa
Detection of cellular forces plays an important role in investigating the mechanical basis of cells. As nanomechanical sensors can directly detect surface stress, they can be utilized to detect cellular forces. In the present study, we perform quantitative simulations of nanomechanical sensors for the detection of cellular forces using finite element analyses (FEA). We focus on two types of nanomechanical sensors: a cantilever-type sensor and a membrane-type surface stress sensor (MSS). It is found that sensing signals can be obtained when cells on the nanomechanical sensors synchronize their motions...
2016: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/27800698/on-the-importance-of-3d-geometrically-accurate-and-subject-specific-finite-element-analysis-for-evaluation-of-in-vivo-soft-tissue-loads
#10
Kevin M Moerman, Marc van Vijven, Leandro R Solis, Eline E van Haaften, Arjan C Y Loenen, Vivian K Mushahwar, Cees W J Oomens
Pressure ulcers are a type of local soft tissue injury due to sustained mechanical loading and remain a common issue in patient care. People with spinal cord injury (SCI) are especially at risk of pressure ulcers due to impaired mobility and sensory perception. The development of load improving support structures relies on realistic tissue load evaluation e.g. using finite element analysis (FEA). FEA requires realistic subject-specific mechanical properties and geometries. This study focuses on the effect of geometry...
November 1, 2016: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/27766224/improvement-of-meloxicam-solubility-using-a-%C3%AE-cyclodextrin-complex-prepared-via-the-kneading-method-and-incorporated-into-an-orally-disintegrating-tablet
#11
Ahmad Ainurofiq, Syaiful Choiri, Muhamad Ali Azhari, Chaterin Romauli Siagian, Bambang Budi Suryadi, Fea Prihapsara, Sholichah Rohmani
Purpose: The aim of this research was to formulate and develop an orally disintegrating tablet (ODT) that incorporated a MEL/β-CD complex, using a quality by design (QbD) approach to enhance solubility and drug release. Methods: Multiple regression linear analysis was conducted to develop the kneading process and ODT formulation. Mixing time and amount of solvent were used as independent variables in kneading process optimisation, while the superdisintegrants were used to obtain the desired formulation. Fourier transform infrared spectroscopy and differential scanning calorimetry were performed for complex characterization...
September 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27763515/analysis-of-the-effects-of-thermal-environment-on-optical-systems-for-navigation-guidance-and-control-in-supersonic-aircraft-based-on-empirical-equations
#12
Xuemin Cheng, Yikang Yang, Qun Hao
The thermal environment is an important factor in the design of optical systems. This study investigated the thermal analysis technology of optical systems for navigation guidance and control in supersonic aircraft by developing empirical equations for the front temperature gradient and rear thermal diffusion distance, and for basic factors such as flying parameters and the structure of the optical system. Finite element analysis (FEA) was used to study the relationship between flying and front dome parameters and the system temperature field...
October 17, 2016: Sensors
https://www.readbyqxmd.com/read/27762276/3d-mapping-of-elastic-modulus-using-shear-wave-optical-micro-elastography
#13
Jiang Zhu, Li Qi, Yusi Miao, Teng Ma, Cuixia Dai, Yueqiao Qu, Youmin He, Yiwei Gao, Qifa Zhou, Zhongping Chen
Elastography provides a powerful tool for histopathological identification and clinical diagnosis based on information from tissue stiffness. Benefiting from high resolution, three-dimensional (3D), and noninvasive optical coherence tomography (OCT), optical micro-elastography has the ability to determine elastic properties with a resolution of ~10 μm in a 3D specimen. The shear wave velocity measurement can be used to quantify the elastic modulus. However, in current methods, shear waves are measured near the surface with an interference of surface waves...
October 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27747709/biomechanical-effects-of-offset-placement-of-dental-implants-in-the-edentulous-posterior-mandible
#14
Yuta Shimura, Yuji Sato, Noboru Kitagawa, Miyuki Omori
BACKGROUND: Proper implant placement is very important for long-term implant stability. Recently, numerous biomechanical studies have been conducted to clarify the relationship between implant placement and peri-implant stress. The placement of multiple implants in the edentulous posterior mandible has been studied by geometric analysis, three-dimensional finite element analysis (FEA), model experimentation, etc. Offset placement is a technique that reduces peri-implant load. However, few studies have used multiple analyses to clarify the value of the offset placement under identical conditions...
December 2016: Int J Implant Dent
https://www.readbyqxmd.com/read/27747632/a-biomechanical-investigation-of-mandibular-molar-implants-reproducibility-and-validity-of-a-finite-element-analysis-model
#15
Miyuki Omori, Yuji Sato, Noboru Kitagawa, Yuta Shimura, Manabu Ito
BACKGROUND: Three-dimensional finite element analysis (FEA) is effective in analyzing stress distributions around dental implants. However, FEA of living tissue involves many conditions, and the structures and behaviors are complex; thus, it is difficult to ensure the validity of the results. To verify reproducibility and validity, we embedded implants in experimental models and constructed FEA models; implant displacements were compared under various loading conditions. METHODS: Implants were embedded in the molar regions of artificial mandibles to fabricate three experimental models...
December 2015: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/27731482/comparison-of-frictional-resistance-among-conventional-active-and-passive-selfligating-brackets-with-different-combinations-of-arch-wires-a-finite-elements-study
#16
Sandra L Gómez, Yesid Montoya, Nora L Garcia, Ana L Virgen, Javier E Botero
The aim of this study was to compare frictional resistance among conventional, passive and active selfligating brackets using Finite Elements Analysis (FEA). Seventynine (79) slide tests were performed by combining an upper first bicuspid conventional bracket, 0.018" stainless steel wires and 0.010" ligature by means of an INSTRON 3345 load system to obtain average maximum static frictional resistance (MSFR). This value was compared to the FR (frictional resistance) obtained by simulation of a slide of the same combination by FEA following conventional bracket modeling by means of Computer Aided Design (CAD)...
September 2016: Acta Odontológica Latinoamericana: AOL
https://www.readbyqxmd.com/read/27722020/a-multiscale-3d-finite-element-analysis-of-fluid-solute-transport-in-mechanically-loaded-bone
#17
Lixia Fan, Shaopeng Pei, X Lucas Lu, Liyun Wang
The transport of fluid, nutrients, and signaling molecules in the bone lacunar-canalicular system (LCS) is critical for osteocyte survival and function. We have applied the fluorescence recovery after photobleaching (FRAP) approach to quantify load-induced fluid and solute transport in the LCS in situ, but the measurements were limited to cortical regions 30-50 μm underneath the periosteum due to the constrains of laser penetration. With this work, we aimed to expand our understanding of load-induced fluid and solute transport in both trabecular and cortical bone using a multiscaled image-based finite element analysis (FEA) approach...
2016: Bone Research
https://www.readbyqxmd.com/read/27718416/when-pathological-and-radiological-correlation-is-achieved-excision-of-fibroadenoma-with-lobular-neoplasia-on-core-biopsy-is-not-warranted
#18
C Fives, C J O'Neill, R Murphy, M A Corrigan, M J O'Sullivan, L Feeley, M W Bennett, F O'Connell, T J Browne
BACKGROUND: The diagnosis and management of lobular neoplasia (LN) including lobular carcinoma in situ (LCIS) and atypical lobular hyperplasia (ALH) remains controversial. Current management options after a core needle biopsy (CNB) with lobular neoplasia (LN) incorporating both ALH and LCIS include excision biopsy or careful clinical and radiologic follow up. METHODS: A retrospective analysis of the surgical database at Cork University Hospital was performed to identify all core needle biopsies from January 1st 2010 to 31st December 2013 with a diagnosis of FA who subsequently underwent surgical excision biopsy...
December 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27717540/notch-sensitivity-jeopardizes-titanium-locking-plate-fatigue-strength
#19
Wo-Jan Tseng, Ching-Kong Chao, Chun-Chin Wang, Jinn Lin
INTRODUCTION: Notch sensitivity may compromise titanium-alloy plate fatigue strength. However, no studies providing head-to-head comparisons of stainless-steel or titanium-alloy locking plates exist. MATERIALS AND METHODS: Custom-designed identically structured locking plates were made from stainless steel (F138 and F1314) or titanium alloy. Three screw-hole designs were compared: threaded screw-holes with angle edges (type I); threaded screw-holes with chamfered edges (type II); and non-threaded screw-holes with chamfered edges (type III)...
December 2016: Injury
https://www.readbyqxmd.com/read/27716568/plaque-structural-stress-assessed-by-virtual-histology-intravascular-ultrasound-predicts-dynamic-changes-in-phenotype-and-composition-of-untreated-coronary-artery-lesions
#20
Soo-Jin Kang, Hojin Ha, June-Goo Lee, Seung-Bong Han, Gary S Mintz, Jihoon Kweon, Mineok Chang, Jae-Hyung Roh, Pil Hyung Lee, Sung-Han Yoon, Jung-Min Ahn, Duk-Woo Park, Seung-Whan Lee, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park, Young-Hak Kim
BACKGROUND AND AIMS: We aimed to determine whether finite element analysis (FEA)-derived plaque structural stress (PSS) analysis can predict serial changes in atheroma volume, type, and tissue composition within a fibroatheroma-containing target segment. METHODS: Overall, 210 patients (210 untreated coronary artery lesions) underwent serial (baseline and 12-month follow-up) grayscale- and virtual histology (VH)-intravascular ultrasound (IVUS). Baseline PSS was assessed at the minimal lumen and at the maximum necrotic core (NC) sites...
September 30, 2016: Atherosclerosis
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