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https://www.readbyqxmd.com/read/28797976/physiological-mechanisms-of-water-and-electrolyte-disturbances-following-transsphenoidal-pituitary-surgery
#1
Evan T Blair, John S Clemmer, H Louis Harkey, Robert L Hester, W Andrew Pruett
BACKGROUND: Disturbances in water and electrolyte homeostasis are common following transsphenoidal surgery. These disorders are variable and unpredictable, increasing patient risk and complicating postsurgical treatment. Clinically, it is generally accepted that damage to the pituitary is the etiology, but the mechanisms behind the response variability and underlying pathophysiology remains unknown. OBJECTIVE: To test the hypothesis that changing the degree of damage to the pituitary stalk produces a spectrum of water and electrolyte disturbance along which all presentations of postsurgical water and electrolyte disturbances can be identified...
August 7, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28792616/proteomic-profiling-of-liver-and-plasma-in-chronic-ethanol-feeding-model-of-hepatic-alcohol-dehydrogenase-deficient-deer-mice
#2
Kamlesh K Bhopale, Samir M Amer, Lata Kaphalia, Kizhake V Soman, John E Wiktorowicz, G A Shakeel Ansari, Bhupendra S Kaphalia
BACKGROUND: Chronic alcohol abuse, a major risk factor for such diseases as hepatitis and cirrhosis, impairs hepatic alcohol dehydrogenase (ADH, key ethanol metabolizing enzyme). Therefore, differentially altered hepatic and plasma proteomes were identified in chronic ethanol feeding model of hepatic ADH-deficient (ADH(-) ) deer mice to understand the metabolic basis of alcoholic liver disease (ALD). METHODS: ADH(-) deer mice were fed 3.5g% ethanol via Lieber-DeCarli liquid diet daily for three months, and histology of the liver assessed...
August 9, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28777815/biochemical-adaptations-of-four-submerged-macrophytes-under-combined-exposure-to-hypoxia-and-hydrogen-sulphide
#3
Mahfuza Parveen, Takashi Asaeda, Md H Rashid
A hydroponic experiment was performed to investigate the stress responses and biochemical adaptations of four submerged macrophytes, Potamogeton crispus, Myriophyllum spicatum, Egeria densa, and Potamogeton oxyphyllus, to the combined exposure of hypoxia and hydrogen sulfide (H2S, provided by NaHS). The investigated plants were subjected to a control, hypoxia, 0.1mM NaHS, 0.5 mM NaHS, 0.1 mM NaHS+hypoxia and 0.5 mM NaHS+hypoxia conditions. All experimental plants grew optimally under control, hypoxic and NaHS conditions in comparison to that grown in the combined exposure of hypoxia and hydrogen sulfide...
2017: PloS One
https://www.readbyqxmd.com/read/28772201/effective-immobilization-of-alcohol-dehydrogenase-on-carbon-nanoscaffolds-for-ethanol-biofuel-cell
#4
Yogeswaran Umasankar, Bal-Ram Adhikari, Aicheng Chen
An efficient approach for immobilizing alcohol dehydrogenase (ADH) while enhancing its electron transfer ability has been developed using poly(2-(trimethylamino)ethyl methacrylate) (MADQUAT) cationic polymer and carbon nanoscaffolds. The carbon nanoscaffolds were comprised of single-walled carbon nanotubes (SWCNTs) wrapped with reduced graphene oxide (rGO). The ADH entrapped within the MADQUAT that was present on the carbon nanoscaffolds exhibited a high electron exchange capability with the electrode through its cofactor β-nicotinamide adenine dinucleotide hydrate and β-nicotinamide adenine dinucleotide reduced disodium salt hydrate (NAD(+)/NADH) redox reaction...
July 26, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/28770372/the-impact-of-anger-in-adherence-to-treatment-and-beliefs-about-disease-1%C3%A2-year-after-stroke
#5
A Catarina Santos, José M Ferro
Anger is a frequent neuropsychiatric symptom after stroke, which can disrupt treatment and recovery, in particular by affecting adherence behaviour to treatment and health care education. This study aimed to follow-up a cohort of stroke patients 12 months after their stroke to describe the presence of anger, compare levels and profile of acute and post-acute anger and analyse its impact on the adherence to treatment and beliefs about stroke. We followed (13.3 months mean follow-up) 91 stroke patients with a standardized protocol, using State-Trait Anger Expression Inventory-2 (STAXI-2) to assess the frequency and profile of anger and its components and one questionnaire to measure adherence to treatment and health education (meaning on the treatment) (Adh-T)...
August 2, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28769575/distinct-prognostic-values-of-alcohol-dehydrogenase-mrna-expression-in-pancreatic-adenocarcinoma
#6
Xiwen Liao, Rui Huang, Xiaoguang Liu, Chuangye Han, Long Yu, Shijun Wang, Na Sun, Bopei Li, Xin Ning, Tao Peng
BACKGROUND: Alcohol dehydrogenase (ADH) isoenzymes have been reported as a potential diagnostic marker for pancreatic cancer, but their prognostic value in pancreatic cancer remains unclear. The aim of this investigation was to identify the prognostic value of ADH genes in human patients with pancreatic adenocarcinoma (PAAD). MATERIALS AND METHODS: An RNA sequencing dataset and corresponding survival profiles of PAAD were obtained from The Cancer Genome Atlas. Survival analysis and gene set enrichment analysis were used to investigate the prediction value and potential mechanism of ADH genes in PAAD prognosis...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28760442/integrating-a-light-driven-coenzyme-regeneration-system-by-expression-of-an-alcohol-dehydrogenase-in-phototrophic-bacteria-for-synthesis-of-chiral-alcohol
#7
Xiaoqiang Ma, Hong Liang, Chenxi Ning, Senwen Deng, Erzheng Su
Herein, we reported that Rhodobacter sphaeroides (R. sphaeroides) can be engineered by heterologous expression of an alcohol dehydrogenase (adh) from Leifsonia sp. to build a light-driven cofactor regeneration system for synthesis of chiral alcohol. The model substrate, 3'-chloroacetophenone, can be reduced by the engineered R. sphaeroides to (R)-1-(3-chlorophenyl) ethanol with an enantiomeric excess (e.e.) value of more than 99% in an n-hexane/aqueous biphasic media. This system, which is fully controlled by light, exhibited potential power to be an alternative cofactor regeneration platform for cheap synthesis of various chiral alcohols via the cloning other oxidoreductases with diverse characteristics...
July 29, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28759873/the-alterations-in-alcohol-dehydrogenase-and-aldehyde-dehydrogenase-activities-in-the-sera-of-patients-with-renal-cell-carcinoma
#8
Karolina Orywal, Wojciech Jelski, Tadeusz Werel, Maciej Szmitkowski
PURPOSE: In a previous study we showed that the total activity of alcohol dehydrogenase (ADH) and its isoenzyme class I was significantly higher in renal cancer (RCC) cells compared to normal kidney. The aim of this study was to compare the activities of ADH isoenzymes and aldehyde dehydrogenase (ALDH) in the sera of patients with different stages of RCC and healthy subjects. MATERIALS AND METHODS: Serum samples were taken from 54 patients with clear cell RCC (17 patients in stage II, 22 in stage III and 15 in stage IV) and 52 healthy patients...
July 28, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28758645/fluorometric-gas-imaging-system-sniff-cam-using-the-extinction-of-nadh-with-an-adh-reverse-reaction-for-acetaldehyde-in-the-gas-phase
#9
Kenta Iitani, Toshiyuki Sato, Munire Naisierding, Yuuki Hayakawa, Koji Toma, Takahiro Arakawa, Kohji Mitsubayashi
A gas-imaging system (sniff-cam) that allows fluorometric visualization of a two-dimensional (2-D) distribution of gaseous acetaldehyde (AcH) was developed. It employed a reverse reaction of a nicotinamide adenine dinucleotide (NADH) dependent enzyme that led to consumption of NADH in that reaction. The system was constructed with a highly sensitive camera, an ultraviolet light emitting diode array sheet, two band pass filters and an alcohol dehydrogenase (ADH)-immobilized mesh that was used for AcH detection...
July 31, 2017: Analyst
https://www.readbyqxmd.com/read/28753473/reduction-mammaplasty-in-patients-with-history-of-breast-cancer-the-incidence-of-occult-cancer-and-high-risk-lesions
#10
Päivi A Merkkola-von Schantz, Tiina A Jahkola, Leena A Krogerus, Susanna M C Kauhanen
INTRODUCTION: Contralateral reduction mammaplasty is regularly included in the treatment of breast cancer patients. We analyzed the incidence of occult breast cancer and high-risk lesions in reduction mammaplasty specimens of women with previous breast cancer. We also analyzed if timing of reduction mammaplasty in relation to oncological treatment influenced the incidence of abnormal findings, and compared if patients with abnormal contralateral histopathology differed from the study population in terms of demographics...
July 25, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28752682/impairment-of-retinoic-acid-signaling-in-cornelia-de-lange-syndrome-fibroblasts
#11
Grazia Fazio, Laura Rachele Bettini, Silvia Rigamonti, Dorela Meta, Andrea Biondi, Giovanni Cazzaniga, Angelo Selicorni, Valentina Massa
BACKGROUND: Cornelia de Lange syndrome (CdLS) is a rare genetic disorder affecting the neurodevelopment, gastrointestinal, musculoskeletal systems. CdLS is caused by mutations within NIPBL, SMC1A, SMC3, RAD21, and HDAC8 genes. These genes codify for the "cohesin complex" playing a role in chromatid adhesion, DNA repair and gene expression regulation. The aim of this study was to investigate retinoic acid (RA) signaling pathway, a master developmental regulator, in CdLS cells. METHODS: Skin biopsies from CdLS patients and healthy controls were cultured and derived primary fibroblast cells were treated with RA or dimethyl sulfoxide (vehicle)...
July 28, 2017: Birth defects research
https://www.readbyqxmd.com/read/28750526/improved-sensitivity-of-acetaldehyde-biosensor-by-detecting-adh-reverse-reaction-mediated-nadh-fluoro-quenching-for-wine-evaluation
#12
Kenta Iitani, Po-Jen Chien, Takuma Suzuki, Koji Toma, Takahiro Arakawa, Yasuhiko Iwasaki, Kohji Mitsubayashi
Acetaldehyde (AcH) is found in ambient air, foods, and the living body. This toxic substance is also contained in wine and known as an important ingredient affecting the quality of wine. Herein, we constructed and evaluated two different fiber-optic biosensors for measurement of AcH in the liquid phase (AcH biosensor) using aldehyde dehydrogenase (ALDH) or alcohol dehydrogenase (ADH). The AcH biosensor measured a concentration of AcH using fluorescence intensity of a reduced form of nicotinamide adenine dinucleotide (NADH) that was produced or consumed via catalytic reaction of the respective enzyme...
July 28, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28745469/reliability-of-bounce-drop-jump-parameters-within-elite-male-rugby-players
#13
Lisa Costley, Eric Wallace, Michael Johnston, Rodney Kennedy
BACKGROUND: The aims of the study were to investigate the number of familiarisation sessions required to establish reliability of the bounce drop jump (BDJ) and subsequent reliability once familiarisation is achieved. METHOD: Seventeen trained male athletes completed 4 BDJs in 4 separate testing sessions. Force-time data from a 20 cm BDJ was obtained using two force plates (ensuring ground contact < 250 ms). Subjects were instructed to 'jump for maximal height and minimal contact time' while the best and average of four jumps were compared...
July 25, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28742508/clinical-characterization-of-a-novel-calcium-sensing-receptor-genetic-alteration-in-a-greek-patient-with-autosomal-dominant-hypocalcemia-type-1
#14
Anna Papadopoulou, Evangelia Gole, Katerina Melachroinou, Theoni Trangas, Evaggelia Bountouvi, Anastasios Papadimitriou
OBJECTIVE: Autosomal dominant hypocalcemia (ADH) is a rare familial or sporadic syndrome associated with activating mutations in the calcium sensing receptor (CaSR) gene. The aim of this study was to assess the functional significance of a novel CaSR mutation and, moreover, to present the clinical characteristics and the bone mineral density (BMD) progression from early childhood to late puberty in a patient with ADH. DESIGN: Genetic analysis of the CaSR gene was performed in a patient who presented in the neonatal period with hypocalcemic seizures and biochemical features of ADH...
April 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28735760/first-characterization-of-immunogenic-conjugates-of-vi-negative-salmonella-typhi-o-specific-polysaccharides-with-repa-protein-for-vaccine-development
#15
M Salman, F St Michael, A Ali, A Jabbar, C Cairns, A C Hayes, M Rahman, M Iqbal, A Haque, A D Cox
Efficacious typhoid vaccines for young children will significantly reduce the disease burden in developing world. The Vi polysaccharide based conjugate vaccines (Vi-rEPA) against Salmonella Typhi Vi positive strains has shown high efficacy but may be ineffective against Vi negative S. Typhi. In this study, for the first time, we report the synthesis and evaluation of polysaccharide-protein conjugates of Vi negative S. Typhi as potential vaccine candidates. Four different conjugates were synthesized using recombinant exoprotein A of Pseudomonas aeruginosa (rEPA) and human serum albumin (HSA) as the carrier proteins, using either direct reductive amination or an intermediate linker molecule, adipic acid dihydrazide (ADH)...
July 21, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28735060/individual-roles-of-brain-and-serum-alcohol-dehydrogenase-isoforms-in-regulation-of-alcohol-consumption-in-spf-wistar-rats
#16
Vsevolod V Pavshintsev, Nikita A Mitkin, Olga Y Frolova, Ekaterina A Kushnir, Olga A Averina, Maxim L Lovat
Alcohol dehydrogenases (ADH) are key enzymes of ethanol metabolism that mediate its oxidation to acetaldehyde. ADHs are also able to oxidize some types of neurotransmitters such as dopamine, serotonin and norepinephrine. Increased level of ADHs activity, induced by chronic alcohol consumption, is presumably associated with disturbed neurotransmitters metabolism that leads to stable alcohol craving. As earlier reported, intraperitoneal administration of 4-methilpirasole (non-specific inhibitor of ADHs) has shown to provide a short-term anti-alcoholic effect, but individual roles of ADH isoforms in this process were still unclear...
July 20, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28731573/effect-of-alcohol-dehydrogenase-1b-and-7-polymorphisms-on-blood-ethanol-and-acetaldehyde-concentrations-in-healthy-subjects-with-a-history-of-moderate-alcohol-consumption
#17
Roberta Pastorino, Luigi Iuliano, Alessia Vecchioni, Dario Arzani, Mirta Milic, Francesca Annunziata, Chiara Zerbinati, Ettore Capoluongo, Stefano Bonassi, James D McKay, Stefania Boccia
AIMS: To evaluate the effect of ADH1B and ADH7 genotypes on blood acetaldehyde and ethanol levels after alcohol ingestion, and to measure the genotoxic effect of smoking and ethanol on the buccal cells, also controlling for ADH variants. METHODS: We recruited healthy Italian subjects with at least a moderate history of alcohol consumption. All subjects were given an alcoholic drink of 0.4 g ethanol /kg of body weight. Blood venous samples were collected at baseline, and 30, 60, 90 and 120 minutes after ingestion...
July 21, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28716098/awakening-sleeping-beauty-production-of-propionic-acid-in-escherichia-coli-through-the-sbm-operon-requires-the-activity-of-a-methylmalonyl-coa-epimerase
#18
Ricardo Axayacatl Gonzalez-Garcia, Tim McCubbin, Annalena Wille, Manuel Plan, Lars Keld Nielsen, Esteban Marcellin
BACKGROUND: Propionic acid is used primarily as a food preservative with smaller applications as a chemical building block for the production of many products including fabrics, cosmetics, drugs, and plastics. Biological production using propionibacteria would be competitive against chemical production through hydrocarboxylation of ethylene if native producers could be engineered to reach near-theoretical yield and good productivity. Unfortunately, engineering propionibacteria has proven very challenging...
July 17, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28714397/prognostic-value-of-copeptin-in-chronic-kidney-disease-from-general-population-to-end-stage-renal-disease
#19
Edyta Golembiewska, Anna Machowska, Peter Stenvinkel, Bengt Lindholm
Arginine vasopressin (AVP), also known as antidiuretic hormone (ADH), is released in response to osmotic and non-osmotic stimuli and plays a key role in many physiologic and pathologic processes. The main function of AVP is the control of fluid homeostasis by inducing water conservation by the kidney, but it also stimulates arteriolar vasoconstriction and the release of adrenocorticotropic hormone (ACTH). These actions are mediated by different AVP receptors located on various target cells. Produced in hypothalamus from a larger precursor, pre-proAVP, AVP is produced in equimolar amounts to copeptin, a glycopeptide with yet unknown biologic function...
July 14, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28711978/the-activity-of-the-antioxidant-defense-system-of-the-weed-species-senna-obtusifolia-l-and-its-resistance-to-allelochemical-stress
#20
Érica Marusa Pergo Coelho, Mauro Cezar Barbosa, Márcio Shigueaki Mito, Gislaine Cristiane Mantovanelli, Rubem Silvério Oliveira, Emy Luiza Ishii-Iwamoto
Senna obtusifolia L., a common weed in the tropical and subtropical regions of the world, is able to germinate under adverse environmental conditions, suggesting that this species has efficient stress-adaptation strategies. The aims of the present work were to examine the energy metabolism and the antioxidant defense system of the Senna obtusifolia L. during seed germination and initial growth, and the responses to allelochemical-induced stress. Respiratory activity, the activities of alcohol dehydrogenase (ADH), superoxide dismutase (SOD), catalase (CAT),guaicol peroxidase (POD), ascorbate peroxidase (APX), glutathione reductase (GR), lipoxygenase (LOX) and the content of malondialdehyde (MDA) and glutathione (GSSG and GSH) were measured...
July 15, 2017: Journal of Chemical Ecology
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