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https://www.readbyqxmd.com/read/27935121/urea-is-successful-in-treating-inappropriate-antidiuretic-hormone-secretion-in-an-infant
#1
Stephanie Dufek, Christine Booth, Adrian Carroll, William Van't Hoff, Robert Kleta, Detlef Bockenhauer
The syndrome of inappropriate antidiuretic hormone (SIADH) consists of a number of key features, namely hyponatraemia, inappropriate urinary concentration and clinical euvolaemia or hypervolaemia. It is caused by inappropriate secretion of the antidiuretic hormone (ADH), which activates the vasopressin type 2 receptor (AVPR2) in the principal cells of the collecting duct of the kidney and leads to increased reabsorption of water through aquaporin 2 channels. Common causes of SIADH in children include trauma, asphyxia, pain, stress, certain drugs and recent neurosurgery (1)...
December 9, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27924150/increasing-n-butanol-production-with-saccharomyces-cerevisiae-by-optimizing-acetyl-coa-synthesis-nadh-levels-and-trans-2-enoyl-coa-reductase-expression
#2
Virginia Schadeweg, Eckhard Boles
BACKGROUND: n-Butanol can serve as an excellent gasoline substitute. Naturally, it is produced by some Clostridia species which, however, exhibit only limited suitability for industrial n-butanol production. The yeast Saccharomyces cerevisiae would be an ideal host due to its high robustness in fermentation processes. Nevertheless, n-butanol yields and titers obtained so far with genetically engineered yeast strains are only low. RESULTS: In our recent work, we showed that n-butanol production via a clostridial acetoacetyl-CoA-derived pathway in engineered yeast was limited by the availability of coenzyme A (CoA) and cytosolic acetyl-CoA...
2016: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/27919364/double-heterozygous-autosomal-dominant-hypercholesterolemia-clinical-characterization-of-an-underreported-disease
#3
Barbara Sjouke, Joep C Defesche, Merel L Hartgers, Albert Wiegman, Jeanine E Roeters van Lennep, John J Kastelein, G Kees Hovingh
INTRODUCTION: Autosomal dominant hypercholesterolemia (ADH), characterized by high-plasma low-density lipoprotein cholesterol (LDL-C) levels and premature cardiovascular disease (CVD) risk, is caused by mutations in LDLR, APOB, and/or PCSK9. OBJECTIVE: To describe the clinical characteristics of "double-heterozygous carriers," with 2 mutations in 2 different ADH causing genes, that is, LDLR and APOB or LDLR and PCSK9. METHODS: Double heterozygotes were identified in the database of the national referral laboratory for DNA diagnostics of inherited dyslipidemias...
November 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27908777/mdr-alcohol-dehydrogenases
#4
Hans Jörnvall
Close to 80 years of research have brought MDR alcohol dehydrogenases (ADHs) from unknown molecular concepts to molecules known in exact detail regarding structural, functional and evolutionary properties. They can be traced backwards in at least six stages of development, to essentially the origin of cellular life, and have been monitored in a long series of biannual meetings on "Carbonyl Metabolism". In between each of these meetings, a roughly three-fold increase in known totals of MDR databank entries has been apparent, bringing the total now of known MDR-ADH entries to approaching half a million forms...
November 28, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27893862/diversity-and-evolutionary-analysis-of-iron-containing-type-iii-alcohol-dehydrogenases-in-eukaryotes
#5
Carlos Gaona-López, Adriana Julián-Sánchez, Héctor Riveros-Rosas
BACKGROUND: Alcohol dehydrogenase (ADH) activity is widely distributed in the three domains of life. Currently, there are three non-homologous NAD(P)+-dependent ADH families reported: Type I ADH comprises Zn-dependent ADHs; type II ADH comprises short-chain ADHs described first in Drosophila; and, type III ADH comprises iron-containing ADHs (FeADHs). These three families arose independently throughout evolution and possess different structures and mechanisms of reaction. While types I and II ADHs have been extensively studied, analyses about the evolution and diversity of (type III) FeADHs have not been published yet...
2016: PloS One
https://www.readbyqxmd.com/read/27864057/inhibitory-effects-of-the-dietary-flavonoid-quercetin-on-the-enzyme-activity-of-zinc-ii-dependent-yeast-alcohol-dehydrogenase-spectroscopic-and-molecular-docking-studies
#6
Sutanwi Bhuiya, Lucy Haque, Ankur Bikash Pradhan, Suman Das
A multispectroscopic exploration was employed to investigate the interaction between the metallo-enzyme alcohol dehydrogenase (ADH) from yeast with bioflavonoid quercetin (QTN). Here, we have characterized the complex formation between QTN and Zn(2+) in aqueous solution and then examined the effect of such complex formation on the enzymatic activity of a zinc(II)-dependent enzyme alcohol dehydrogenase from yeast. We have observed an inhibition of enzymatic activity of ADH in presence of QTN. Enzyme inhibition kinetic experiments revealed QTN as a non-competitive inhibitor of yeast ADH...
November 15, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27849176/both-adhe-and-a-separate-nadph-dependent-alcohol-dehydrogenase-adha-are-necessary-for-high-ethanol-production-in-thermoanaerobacterium-saccharolyticum
#7
Tianyong Zheng, Daniel G Olson, Sean J Murphy, Xiongjun Shao, Liang Tian, Lee R Lynd
: Thermoanaerobacterium saccharolyticum has been engineered to produce ethanol at ∼90% theoretical yield and titer of 70 g/L. Its ethanol-producing ability has drawn attention to its metabolic pathways, which could potentially be transferred to other organisms of interest. Here we report that the iron-containing AdhA is important for ethanol production in the high-ethanol strain of T. saccharolyticum (LL1049). A single-gene deletion of adhA in LL1049 reduced ethanol production by ∼50%, whereas multiple gene deletions of all annotated alcohol dehydrogenases except adhA and adhE did not affect ethanol production...
November 14, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/27832842/flat-epithelial-atypia-on-core-needle-biopsy-must-we-surgically-excise
#8
A A Acott, A T Mancino
: Breast flat epithelial atypia (FEA) often coexists with more aggressive pathology and excision is currently recommended when diagnosed by core needle biopsy (CNB). Recent studies suggest isolated FEA has a low association with carcinoma and may warrant close surveillance. A radiology database containing 2189 breast CNB was reviewed for isolated FEA or FEA in combination with atypical pathology. 79 patients had FEA. There were 48/79 with isolated FEA and 31/79 concomitant FEA with ADH, ALH, or LCIS...
October 29, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27831531/subareolar-sclerosing-ductal-hyperplasia-further-characterization-of-a-distinctive-clinicopathological-entity
#9
REVIEW
Esther Cheng, Timothy M D'Alfonso, Maria Arafah, Rebecca Marrero Rolon, Paula S Ginter, Syed A Hoda
Subareolar sclerosing duct hyperplasia (SSDH) remains to be fully characterized nearly 20 years after initial description. Thirty-five SSDH cases diagnosed over a 16-year period (January 2000 to December 2015) were reviewed. All patients were female (mean age = 59 years, range = 18-80) who had presented with a unilateral solitary lesion (left 22, right 13) with a mean size of 1.3 cm (range = 0.4-3.0 cm), and showed florid and papillary epithelial hyperplasia with dense sclerosis without involvement of nipple or areolar epidermis...
November 9, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27803672/autosomal-dominant-hypocalcemia-hypoparathyroidism-types-1-and-2
#10
REVIEW
Kelly L Roszko, Ruiye D Bi, Michael Mannstadt
Extracellular calcium is essential for life and its concentration in the blood is maintained within a narrow range. This is achieved by a feedback loop that receives input from the calcium-sensing receptor (CASR), expressed on the surface of parathyroid cells. In response to low ionized calcium, the parathyroids increase secretion of parathyroid hormone (PTH) which increases serum calcium. The CASR is also highly expressed in the kidneys, where it regulates the reabsorption of calcium from the primary filtrate...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27802205/the-role-of-molecular-biomarkers-for-predicting-adjacent-breast-cancer-of-atypical-ductal-hyperplasia-diagnosed-on-core-biopsy
#11
Ayfer Kamali Polat, Atilla Soran, Amal Kanbour-Shakir, Ebru Menekse, Fatih Levent Balci, Ronald Johnson
BACKGROUND: Atypical Ductal Hyperplasia (ADH) is a disease of the proliferative breast lesion characterized with atypia and when diagnosed on core needle biopsy (CNB), excisional biopsy is the current management to exclude adjacent cancer, which may found 10 to 20%. OBJECTIVE: The purpose of the study is to investigate the role of biomarkers on surgical decision after the diagnosis of ADH on CNB. METHODS: Patients with pure ADH on core biopsy were retrospectively selected, and categorized according to final pathology after excision into three groups: Group I (n: 39) ADH; Group II (n: 27) ductal carcinoma in situ (DCIS), and Group III (n: 9) invasive cancer (IC)...
September 26, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27801545/the-allele-frequency-of-aldh2-glu504lys-and-adh1b-arg47his-for-the-ryukyu-islanders-and-their-history-of-expansion-among-east-asians
#12
Kae Koganebuchi, Kuniaki Haneji, Takashi Toma, Keiichiro Joh, Hidenobu Soejima, Kazuma Fujimoto, Hajime Ishida, Motoyuki Ogawa, Tsunehiko Hanihara, Shoji Harada, Shoji Kawamura, Hiroki Oota
OBJECTIVES: A cline of frequencies of the derived allele of the ALDH2 gene, which causes a deficiency of an enzyme and "facial flushing" in humans who drink alcohol, has been known among the people of the Japanese archipelago. This cline is conventionally explained by admixture with immigrants from the Asian continent occurring during the Yayoi period. Previous studies lack sufficient data from the peripheral regions of the indigenous Jomon people, and those data the ADH1B gene that is involved in the Class I ADH gene cluster and contains another variant leading to a functional change...
November 1, 2016: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/27796022/-treatment-of-autosomal-dominant-polycystic-kidney-disease-adpkd-tolvaptan
#13
Massimo Cirillo
The European Medicines Agency approved tolvaptan to slow cyst growth and renal failure progression in adults with ADPKD, glomerular filtration 60 mL/min x 1.73 m2 and rapidly progressive disease. In a multicenter 3-year study, conducted on 1,445 patients with non-genotyped ADPKD, ages 18-50 years, predicted creatinine clearance 60 mL/min and kidney total volume 750 mL, tolvaptan slowed kidney failure progression (-23%-46% for different objectives) and reduced kidney volume increase and pain without effects on hypertension and albuminuria...
September 2016: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/27791418/a-review-of-the-management-of-blunt-splenic-trauma-in-england-and-wales-have-regional-trauma-networks-influenced-management-strategies-and-outcomes
#14
P Yiannoullou, C Hall, K Newton, B Pearce, O Bouamra, T Jenks, A B Scrimshire, G Hughes, F Lecky, Adh Macdonald
INTRODUCTION The spleen remains one of the most frequently injured organs following blunt abdominal trauma. In 2012, regional trauma networks were launched across England and Wales with the aim of improving outcomes following trauma. This retrospective cohort study investigated the management and outcomes of blunt splenic injuries before and after the establishment of regional trauma networks. METHODS A dataset was drawn from the Trauma Audit Research Network database of all splenic injuries admitted to English and Welsh hospitals from 1 April 2010 to 31 March 2014...
October 28, 2016: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/27790230/comparative-proteomic-analysis-provides-insight-into-the-key-proteins-involved-in-cucumber-cucumis-sativus-l-adventitious-root-emergence-under-waterlogging-stress
#15
Xuewen Xu, Jing Ji, Xiaotian Ma, Qiang Xu, Xiaohua Qi, Xuehao Chen
Waterlogging is a common abiotic stress in both natural and agricultural systems, and it primarily affects plant growth by the slow oxygen diffusion in water. To sustain root function in the hypoxic environment, a key adaptation for waterlogging tolerant plants is the formation of adventitious roots (ARs). We found that cucumber waterlogging tolerant line Zaoer-N seedlings adapt to waterlogging stress by developing a larger number of ARs in hypocotyls, while almost no AR is generated in sensitive line Pepino...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27788775/alpha-ketoglutarate-reduces-ethanol-toxicity-in-drosophila-melanogaster-by-enhancing-alcohol-dehydrogenase-activity-and-antioxidant-capacity
#16
Maria M Bayliak, Halyna V Shmihel, Maria P Lylyk, Kenneth B Storey, Volodymyr I Lushchak
Ethanol at low concentrations (<4%) can serve as a food source for fruit fly Drosophila melanogaster, whereas at higher concentrations it may be toxic. In this work, protective effects of dietary alpha-ketoglutarate (AKG) against ethanol toxicity were studied. Food supplementation with 10-mM AKG alleviated toxic effects of 8% ethanol added to food, and improved fly development. Two-day-old adult flies, reared on diet containing both AKG and ethanol, possessed higher alcohol dehydrogenase (ADH) activity as compared with those reared on control diet or diet with ethanol only...
September 2016: Alcohol
https://www.readbyqxmd.com/read/27785031/personality-features-dissociation-self-stigma-hope-and-the-complex-treatment-of-depressive-disorder
#17
Jan Prasko, Marie Ociskova, Ales Grambal, Zuzana Sigmundova, Petra Kasalova, Marketa Marackova, Michaela Holubova, Kristyna Vrbova, Klara Latalova, Milos Slepecky
OBJECTIVE: Identifying the predictors of response to psychiatric and psychotherapeutic treatments may be useful for increasing treatment efficacy in pharmacoresistant depressive patients. The goal of this study was to examine the influence of dissociation, hope, personality trait, and selected demographic factors in treatment response of this group of patients. METHODS: Pharmacoresistant depressive inpatients were enrolled in the study. All patients completed Clinical Global Impression - both objective and subjective form (CGI), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) at baseline and after 6 weeks of combined pharmacotherapy and psychotherapy (group cognitive-behavioral or group psychodynamic) treatment as an outcome measures...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27782370/pericyte-seeded-dual-peptide-scaffold-with-improved-endothelialization-for-vascular-graft-tissue-engineering
#18
Paola Campagnolo, Adam J Gormley, Lesley W Chow, Anne Géraldine Guex, Paresh A Parmar, Jennifer L Puetzer, Joseph A M Steele, Alexandre Breant, Paolo Madeddu, Molly M Stevens
The development of synthetic vascular grafts for coronary artery bypass is challenged by insufficient endothelialization, which increases the risk of thrombosis, and the lack of native cellular constituents, which favors pathological remodeling. Here, a bifunctional electrospun poly(ε-caprolactone) (PCL) scaffold with potential for synthetic vascular graft applications is presented. This scaffold incorporates two tethered peptides: the osteopontin-derived peptide (Adh) on the "luminal" side and a heparin-binding peptide (Hep) on the "abluminal" side...
October 26, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27776911/genomic-characterization-of-a-fructophilic-bee-symbiont-lactobacillus-kunkeei-reveals-its-niche-specific-adaptation
#19
Shintaro Maeno, Yasuhiro Tanizawa, Yu Kanesaki, Eri Kubota, Himanshu Kumar, Leon Dicks, Seppo Salminen, Junichi Nakagawa, Masanori Arita, Akihito Endo
Lactobacillus kunkeei is classified as a sole obligate fructophilic lactic acid bacterium that is found in fructose-rich niches, including the guts of honeybees. The species is differentiated from other lactobacilli based on its poor growth with glucose, enhanced growth in the presence of oxygen and other electron acceptors, and production of high concentrations of acetate from the metabolism of glucose. These characteristics are similar to phylogenetically distant Fructobacillus spp. In the present study, the genomic structure of L...
December 2016: Systematic and Applied Microbiology
https://www.readbyqxmd.com/read/27736790/engineering-of-a-highly-efficient-escherichia-coli-strain-for-mevalonate-fermentation-through-chromosomal-integration
#20
Jilong Wang, Suthamat Niyompanich, Yi-Shu Tai, Jingyu Wang, Wenqin Bai, Prithviraj Mahida, Tuo Gao, Kechun Zhang
: Chromosomal integration of heterologous metabolic pathways is optimal for industrially relevant fermentation, as plasmid-based fermentation causes extra metabolic burden and genetic instabilities. In this work, chromosomal integration was adapted for the production of mevalonate, which can be readily converted into β-methyl-δ-valerolactone, a monomer for the production of mechanically tunable polyesters. The mevalonate pathway, driven by a constitutive promoter, was integrated into the chromosome of Escherichia coli to replace the native fermentation gene adhE or ldhA The engineered strains (CMEV-1 and CMEV-2) did not require inducer or antibiotic and showed slightly higher maximal productivities (0...
December 15, 2016: Applied and Environmental Microbiology
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