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https://www.readbyqxmd.com/read/28437557/expression-of-catalase-alcohol-dehydrogenase-and-malate-dehydrogenase-in-rot-grains-upon-fungicide-use-on-maize-hybrids-grown-at-different-spacings
#1
E R Kluge, M C Mendes, M V Faria, H O Santos, L A Santos, I E Sandini
In this study, we evaluated the fungicide effect on the incidence of rot grains and expression of catalase (CAT), alcohol dehydrogenase (ADH), and malate dehydrogenase (MDH) enzymes in commercial maize hybrids grown with conventional and reduced spacing in Guarapuava, PR, Brazil. The experiment was designed in random blocks with a 3 × 8-factorial scheme, totaling 24 treatments. The first factor constituted three levels, the first with foliar fungicide application [150.0 g/L trifloxystrobin (15.0%, w/v) + 175...
April 20, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28436515/exploring-the-reversal-of-enantioselectivity-on-a-zinc-dependent-alcohol-dehydrogenase
#2
Miguel A Maria-Solano, Adrian Romero-Rivera, Sílvia Osuna
Alcohol Dehydrogenase (ADH) enzymes catalyse the reversible reduction of prochiral ketones to the corresponding alcohols. These enzymes present two differently shaped active site pockets, which dictate their substrate scope and selectivity. In this study, we computationally evaluate the effect of two commonly reported active site mutations (I86A, and W110T) on a secondary alcohol dehydrogenase from Thermoanaerobacter brockii (TbSADH) through Molecular Dynamics simulations. Our results indicate that the introduced mutations induce dramatic changes in the shape of the active site, but most importantly they impact the substrate-enzyme interactions...
April 24, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28428574/the-oral-health-of-individuals-with-dental-phobia-a-multivariate-analysis-of-the-adult-dental-health-survey-2009
#3
E Heidari, M Andiappan, A Banerjee, J T Newton
Background Adults with dental phobia have been reported to have poorer oral health and oral health-related quality of life. The aim of this study is to explore the social and demographic correlates of oral health and oral health-related quality of life (OH-QoL) of people with dental phobia compared to the non-phobic population in the United Kingdom using the data from Adult Dental Health Survey (ADHS, 2009).Method Secondary analysis of data from the ADHS, 2009. A series of logistic regression analyses was performed with outcome measures of: presence of decayed teeth; presence of missing teeth; pulp exposure ulceration fistula abscess (PUFA) score; periodontal health indices (plaque, bleeding and loss of attachments); and quality of life (oral health impact profile [OHIP14] and oral impacts on daily performance [OIDP])...
April 21, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28415455/heparin-modified-graphene-oxide-for-ph-sensitive-sustained-release-of-doxorubicin-hydrochloride
#4
Baomei Zhang, Xiaoye Yang, Yang Wang, Guangxi Zhai
A novel nanocarrier of heparin (Hep) modified graphene oxide (GO) was fabricated via a linker (adipic dihydrazide) and used as a pH-sensitive drug delivery system for controlling the release of anticancer drug doxorubicin (DOX) for anti-tumor therapy. The finally obtained nanocarrier was GO-ADH-Hep with better stability, blood compatibility and biocompatibility confirmed by the hemolytic test and in vitro cytotoxicity study. Its safety issue was greatly improved via Hep modification. The amount of DOX loaded onto GO-ADH-Hep was significantly high and dependent on pH value...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28404459/preparation-of-pseudomonas-aeruginosa-alginate-flagellin-immunoconjugate
#5
Sobhan Faezi, Ahmad Reza Bahrmand, Mehdi Mahdavi, Seyed Davar Siadat, Soroush Sardari, Iraj Nikokar, Korosh Khanaki, Ebrahim Mirzajani, Gholamreza Goudarzi
Mucoid strains of Pseudomonas aeruginosa are closely associated with chronic pulmonary infections. In this report we describe a straightforward approach to conjugate high molecular weight alginate to type b-flagellin (FLB) and investigation of its bioactivity. The conjugation process was performed by using ADH and EDAC. The endotoxin was eliminated from the candidate vaccine by LPS removal resin followed by LAL test. The bioconjugate molecules were verified by simultaneously determination of polysaccharide/protein content followed by gel filtration chromatography and FTIR spectroscopy...
April 10, 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/28393572/the-role-of-s-nitrosoglutathione-reductase-gsnor-in-human-disease-and-therapy
#6
Scott D Barnett, Iain L O Buxton
S-nitrosoglutathione reductase (GSNOR), or ADH5, is an enzyme in the alcohol dehydrogenase (ADH) family. It is unique when compared to other ADH enzymes in that primary short-chain alcohols are not its principle substrate. GSNOR metabolizes S-nitrosoglutathione (GSNO), S-hydroxymethylglutathione (the spontaneous adduct of formaldehyde and glutathione), and some alcohols. GSNOR modulates reactive nitric oxide (•NO) availability in the cell by catalyzing the breakdown of GSNO, and indirectly regulates S-nitrosothiols (RSNOs) through GSNO-mediated protein S-nitrosation...
April 10, 2017: Critical Reviews in Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28379029/molecular-genetic-background-of-an-autosomal-dominant-hypercholesterolemia-in-the-czech-republic
#7
L Tichý, L Fajkusová, P Zapletalová, L Schwarzová, M Vrablík, T Freiberger
Autosomal dominant hypercholesterolemia (ADH), more known as familial hypercholesterolemia (FH), is a lipid metabolism disorder characterized by an elevation in low-density lipoprotein cholesterol (LDL-C) and increased risk for cardiovascular disease. In this study, we assessed a spectrum of mutations causing ADH in 3914 unrelated Czech patients with clinical diagnosis of hypercholesterolemia. Samples have been collected within the framework of the MedPed project running in the Czech Republic since 1998. So far we have found 432 patients (11...
April 5, 2017: Physiological Research
https://www.readbyqxmd.com/read/28375172/post-colonization-interval-estimates-using-multi-species-calliphoridae-larval-masses-and-spatially-distinct-temperature-data-sets-a-case-study
#8
Courtney R Weatherbee, Jennifer L Pechal, Trevor Stamper, M Eric Benbow
Common forensic entomology practice has been to collect the largest Diptera larvae from a scene and use published developmental data, with temperature data from the nearest weather station, to estimate larval development time and post-colonization intervals (PCIs). To evaluate the accuracy of PCI estimates among Calliphoridae species and spatially distinct temperature sources, larval communities and ambient air temperature were collected at replicate swine carcasses (N = 6) throughout decomposition. Expected accumulated degree hours (ADH) associated with Cochliomyia macellaria and Phormia regina third instars (presence and length) were calculated using published developmental data sets...
April 4, 2017: Insects
https://www.readbyqxmd.com/read/28371946/-qualit%C3%A3-tsmessung-bei-der-behandlung-von-kindern-und-jugendlichen-mit-entwicklungsst%C3%A3-rungen-eine-machbarkeitsstudie-am-beispiel-adhs
#9
Marta Ulusoy, Peter Borusiak, Karin A Hameister, Max Geraedts
The question of a possible presence of attention deficit/hyperactivity disorder (ADHD) is raised with increasing frequency in pediatric practice. There are guidelines and expert recommendations for diagnostic approaches. But there are no instruments available to evaluate the structural, process and outcome quality. In this pilot study, a set of quality indicators on the treatment quality of ADHD was analyzed in terms of their feasibility in tertiary referral centers.A set of 39 quality indicators (QI) on ADHD developed in advance in a multistage procedure was assessed at 9 tertiary referral centers, with a focus on process verifiability and feasibility...
April 3, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28362084/fluorometric-biosniffer-camera-sniff-cam-for-direct-imaging-of-gaseous-ethanol-in-breath-and-transdermal-vapor
#10
Takahiro Arakawa, Toshiyuki Sato, Kenta Iitani, Koji Toma, Kohji Mitsubayashi
Various volatile organic compounds can be found in human transpiration, breath and body odor. In this paper, a novel two-dimensional fluorometric imaging system, known as a "sniffer-cam" for ethanol vapor released from human breath and palm skin was constructed and validated. This imaging system measures ethanol vapor concentrations as intensities of fluorescence through an enzymatic reaction induced by alcohol dehydrogenase (ADH). The imaging system consisted of multiple ultraviolet light emitting diode (UV-LED) excitation sheet, an ADH enzyme immobilized mesh substrate and a high-sensitive CCD camera...
March 31, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28355406/syndrome-of-inappropriate-antidiuretic-hormone-secretion-induced-by-the-phytotherapy-harpagophytum-procumbers-case-report
#11
Renata Reis Carvalho, Camila Dermínio Donadel, Arthur Fernandes Cortez, Vitor Ribeiro Gomes de Almeida Valviesse, Pedro Felipe de Almeida Vianna, Bruno Bordallo Corrêa
INTRODUCTION: The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the inability of antidiuretic hormone (ADH) suppression, compromising the mechanisms of water excretion and urinary concentration. It manifests as hyponatremia and its symptoms, especially neurological. There are many causes that trigger such disease, notably: central nervous system disorders, malignant neoplasm, drugs and others. CASE REPORT: A 65 years female hypertensive patient presented clinical and laboratory manifestations of hyponatremia due to SIADH...
March 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/28338387/comparison-of-the-effects-of-curcumin-and-rg108-on-ngf-induced-pc-12%C3%A2-adh-cell-differentiation-and-neurite-outgrowth
#12
Miriş Dikmen
DNA methyltransferases (DNMTs) are promising epigenetic targets for the development of novel drugs, especially for neurodegenerative disorders. In recent years, there has been increased interest in small molecules that can cross the blood-brain barrier for the treatment of neurodegenerative diseases. Therefore, comparing the neuronal differentiative effects of a natural compound curcumin and a synthetic small molecule RG108 was the aim of this study. The effects of curcumin and RG108 on neuronal differentiation and neurite outgrowth were investigated in the PC-12 Adh cell line...
April 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28337664/aromatase-expression-in-atypical-ductal-hyperplasia-in-women
#13
R J Santen, D C Radisky, A Degnim, M H Frost, C M Vachon, K Ghosh, F Guestini, K M McNamara, H Sasano
PURPOSE: To determine the levels of aromatase in atypical ductal hyperplasia (ADH) lesions, tissue surrounding the ADH, and in dense and non-dense normal breast tissue. We postulated that excess aromatase in breast tissue might, through production of increased estrogen, drive the carcinogenic process. Estrogens and their metabolites are thought to contribute to the development of breast cancer through estrogen receptor-mediated mechanisms and genotoxic effects of estrogen metabolites...
March 23, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28337518/both-atrbohd-and-atrbohf-are-essential-for-mediating-responses-to-oxygen-deficiency-in-arabidopsis
#14
Bo Liu, Lirong Sun, Liya Ma, Fu-Shun Hao
Both AtrbohD and AtrbohF promote the increases in activities of ADH, PDC, LDH, and Ca(2+) levels, and induce the expression of multiple hypoxia response genes, thus improving Arabidopsis adaptation to oxygen deficiency. NADPH oxidase AtrbohD and AtrbohF cooperatively play key roles in regulation of growth and stress signaling in Arabidopsis. However, reports on AtrbohD and AtrbohF functioning together in hypoxia signaling are scarce, and the underlying mechanisms remain elusive. Here, we show that the double null mutant atrbohD/F is more sensitive to oxygen deprivation compared with wild type (WT) and the single mutant atrbohD and atrbohF...
March 23, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/28337428/niacin-mediated-gene-expression-and-role-of-niar-as-a-transcriptional-repressor-of-niax-nadc-and-pnuc-in-streptococcus-pneumoniae
#15
Muhammad Afzal, Oscar P Kuipers, Sulman Shafeeq
NAD (Nicotinamide Adenine Dinucleotide) biosynthesis is vital for bacterial physiology and plays an important role in cellular metabolism. A naturally occurring vitamin B complex, niacin (nicotinic acid), is a precursor of coenzymes NAD and NADP. Here, we study the impact of niacin on global gene expression of Streptococcus pneumoniae D39 and elucidate the role of NiaR as a transcriptional regulator of niaX, nadC, and pnuC. Transcriptome comparison of the D39 wild-type grown in chemically defined medium (CDM) with 0 to 10 mM niacin revealed elevated expression of various genes, including niaX, nadC, pnuC, fba, rex, gapN, pncB, gap, adhE, and adhB2 that are putatively involved in the transport and utilization of niacin...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28336828/-disorders-caused-by-mutations-in-calcium-sensing-receptor-and-related-diseases
#16
Toshimi Michigami
Sensing of extracellular calcium(Ca2+)levels involves the Ca-sensing receptor(CaSR), its downstream signaling molecule Gα11, and the adaptor-related protein complex 2(AP2)that plays a role in clathrin-dependent endocytosis of CaSR. Inactivating mutations in CaSR cause familial hypocalciuric hypercalcemia type 1(FHH1)and neonatal severe hyperparathyroidism(NSHPT), while activating mutations lead to autosomal dominant hypocalcemia type 1(ADH1)and Bartter syndrome type Ⅴ. Recent studies have identified that inactivating mutations in Gα11 and σ-subunit of AP2(AP2σ)also cause FHH, and these conditions have been classified as FHH2 and FHH3, respectively...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28335043/platelet-derived-no-in-subjects-affected-by-type-2-diabetes-with-and-without-complications-is-there-any-relationship-with-their-offspring
#17
Jacopo Sabbatinelli, Arianna Vignini, Eleonora Salvolini, Laura Nanetti, Laura Mazzanti, Rosa Anna Rabini
Macro- and microvascular complications are currently the principal causes of morbidity and mortality in patients with diabetes mellitus. Aim of this study was to determine if type 2 diabetic patients with nephropathy and coronary artery disease showed altered platelet-derived nitric oxide (NO) production, compared with diabetic subjects without complications, and if this alteration is also present in their diabetic offspring. In this case-control observational study, platelet NO and peroxynitrite content was determined on plasma from 60 male adult type 2 diabetic patients and 60 male offspring type 2 diabetic patients...
March 23, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28326750/measuring-hope-standardization-of-the-czech-version-of-the-adult-dispositional-hope-scale-in-healthy-adults
#18
Marie Ociskova, Irena Sobotkova, Jan Prasko, Vladimir Mihal
OBJECTIVES: Hope is an important factor that influences mental state of individuals and efficacy of systematic and supportive psychotherapy. The goal of the study was to translate the Adult Dispositional Hope Scale (ADHS) to Czech, evaluate its psychometric properties and create norms to interpret the scale scores. METHODS: The scale consists of twelve items. Four items assess the ability of pathway thinking, four items measure agency, and the remaining four items are fillers that are not interpreted...
January 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28323660/impact-of-rare-variants-in-autosomal-dominant-hypercholesterolemia-causing-genes
#19
Sebastiano Calandra, Patrizia Tarugi, Stefano Bertolini
PURPOSE OF REVIEW: The systematic analysis of the major candidate genes in autosomal dominant hypercholesterolemia (ADH) and the use of next-generation sequencing (NGS) technology have made possible the discovery of several rare gene variants whose pathogenic effect in most cases remains poorly defined. RECENT FINDINGS: One major advance in the field has been the adoption of a set of international guidelines for the assignment of pathogenicity to low-density lipoprotein receptor (LDLR) gene variants based on the use of softwares, complemented with data available from literature and public databases...
March 18, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28295791/value-of-breast-mri-for-patients-with-a-biopsy-showing-atypical-ductal-hyperplasia-adh
#20
Keiko Tsuchiya, Naoko Mori, David V Schacht, Deepa Sheth, Gregory S Karczmar, Gillian M Newstead, Hiroyuki Abe
PURPOSE: To evaluate the diagnostic value of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) for patients with atypical ductal hyperplasia (ADH) in predicting malignant upgrade. MATERIALS AND METHODS: 3T DCE-MRI was performed for 17 patients with ADH (median age 52, range 42-76) proven by stereotactic biopsy (n = 15), and ultrasound-guided biopsy (n = 2) from January 2011 to April 2015. All patients underwent surgical excision after the MRI...
March 10, 2017: Journal of Magnetic Resonance Imaging: JMRI
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