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https://www.readbyqxmd.com/read/28295791/value-of-breast-mri-for-patients-with-a-biopsy-showing-atypical-ductal-hyperplasia-adh
#1
Keiko Tsuchiya, Naoko Mori, David V Schacht, Deepa Sheth, Gregory S Karczmar, Gillian M Newstead, Hiroyuki Abe
PURPOSE: To evaluate the diagnostic value of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) for patients with atypical ductal hyperplasia (ADH) in predicting malignant upgrade. MATERIALS AND METHODS: 3T DCE-MRI was performed for 17 patients with ADH (median age 52, range 42-76) proven by stereotactic biopsy (n = 15), and ultrasound-guided biopsy (n = 2) from January 2011 to April 2015. All patients underwent surgical excision after the MRI...
March 10, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28274894/effects-of-antrosterol-from-antrodia-camphorata-submerged-whole-broth-on-lipid-homeostasis-antioxidation-alcohol-clearance-and-anti-inflammation-in-livers-of-chronic-alcohol-fed-mice
#2
Yuan-Yen Chang, Yi-Chen Liu, Yueh-Hsiung Kuo, Yi-Ling Lin, Yi-Hsieng Samuel Wu, Jr-Wei Chen, Yi-Chen Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Antrodia camphorata is a functional fungus in Taiwan and owns several pharmacological functions. Antrosterol, a bioactive constitute of sterols in edible Antrodia camphorata submerged whole broth, can protect liver from CCl4 damage via enhancing antioxidant and anti-inflammatory capacities. AIM OF THE STUDY: The aims of this study were to investigate the hepatoprotection of antrosterol against alcohol consumption. MATERIALS AND METHODS: A Lieber-DeCarli regular EtOH diet (EtOH liquid diet, 5% (v/v) alcohol) was applied to induce alcoholic liver damage...
March 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28273416/%C3%AE-helix-mimetics-as-modulators-of-a%C3%AE-self-assembly
#3
Sunil Kumar, Andrew D Hamilton
A key molecular species in Alzheimer's disease (AD) is the Aβ42 alloform of Aβ peptide, which is dominant in the amyloid plaques deposited in the brains of AD patients. Recent studies have decisively demonstrated that the prefibrillar soluble oligomers are the neurotoxic culprits and are associated with the pathology of AD. Nascent Aβ42 is predominantly disordered but samples α-helical conformations covering residues 15-24 and 29-35 in the presence of micelles and structure-inducing solvents. In this report, a focused library of oligopyridylamide based α-helical mimetics was designed to target the central α-helix subdomain of Aβ (Aβ13-26)...
March 8, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28261287/the-diagnostic-value-of-alcohol-dehydrogenase-adh-isoenzymes-and-aldehyde-dehydrogenase-aldh-measurement-in-the-sera-of-patients-with-brain-tumor
#4
Wojciech Jelski, Magdalena Laniewska-Dunaj, Karolina Orywal, Jan Kochanowicz, Robert Rutkowski, Maciej Szmitkowski
INTRODUCTION: Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) exist in the brain. Alcohol dehydrogenase and ALDH are also present in brain tumor cells. Moreover, the activity of class I isoenzymes was significantly higher in cancer than healthy brain cells. The activity of these enzymes in tumor tissue is reflected in the serum and could thus be helpful for diagnostics of brain neoplasms. The aim of this study was to investigate the potential role of ADH and ALDH as markers for brain tumors...
March 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28260904/quality-of-life-self-stigma-and-hope-in-schizophrenia-spectrum-disorders-a-cross-sectional-study
#5
Kristyna Vrbova, Jan Prasko, Marie Ociskova, Dana Kamaradova, Marketa Marackova, Michaela Holubova, Ales Grambal, Milos Slepecky, Klara Latalova
GOALS: The aim of this study was to explore the quality of life, self-stigma, personality traits, and hope in patients with schizophrenia spectrum disorders. PATIENTS AND METHODS: A total of 52 outpatients participated in this cross-sectional study. The attending psychiatrist assessed each patient with Mini International Neuropsychiatric Interview (MINI). The patients then completed Quality of Life Satisfaction and Enjoyment Questionnaire (Q-LES-Q), Internalized Stigma of Mental Illness (ISMI) Scale, Temperament and Character Inventory - Revised (TCI-R), Adult Dispositional Hope Scale (ADHS), Drug Attitude Inventory 10 (DAI-10), and Liebowitz Social Anxiety Scale (LSAS)-Self-report...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28260814/preparation-and-cross-linking-of-all-acrylamide-diblock-copolymer-nano-objects-via-polymerization-induced-self-assembly-in-aqueous-solution
#6
Sarah J Byard, Mark Williams, Beulah E McKenzie, Adam Blanazs, Steven P Armes
Various carboxylic acid-functionalized poly( N , N -dimethylacrylamide) (PDMAC) macromolecular chain transfer agents (macro-CTAs) were chain-extended with diacetone acrylamide (DAAM) by reversible addition-fragmentation chain transfer (RAFT) aqueous dispersion polymerization at 70 °C and 20% w/w solids to produce a series of PDMAC-PDAAM diblock copolymer nano-objects via polymerization-induced self-assembly (PISA). TEM studies indicate that a PDMAC macro-CTA with a mean degree of polymerization (DP) of 68 or higher results in the formation of well-defined spherical nanoparticles with mean diameters ranging from 40 to 150 nm...
February 28, 2017: Macromolecules
https://www.readbyqxmd.com/read/28255630/breast-cancer-detection-by-preoperative-imaging-in-reduction-mammaplasty-patients-a-single-center-study-of-918-patients
#7
Päivi A Merkkola-von Schantz, Susanna M C Kauhanen, Tiina A Jahkola, Leena A Krogerus, Katja S Hukkinen
BACKGROUND: The role of preoperative imaging and the usability of different imaging modalities is highly variable and controversial in reduction mammaplasty patients. Our study describes the imaging process in a single center in regard to modality selection, age and timing, and of the association between imaging and histopathological findings in reduction mammaplasty specimens. METHODS: Nine hundred eighteen women, who underwent reduction mammaplasty during 1.1...
March 2, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28248529/neuronal-circuits-involved-in-osmotic-challenges
#8
M C Dos Santos Moreira, L M Naves, S M Marques, E F Silva, E Colombari, G R Pedrino
The maintenance of plasma sodium concentration within a narrow limit is crucial to life. When it differs from normal physiological patterns, several mechanisms are activated in order to restore body fluid homeostasis. Such mechanisms may be vegetative and/or behavioral, and several regions of the central nervous system (CNS) are involved in their triggering. Some of these are responsible for sensory pathways that perceive a disturbance of the body fluid homeostasis and transmit information to other regions...
February 28, 2017: Physiological Research
https://www.readbyqxmd.com/read/28226194/melatonin-systemically-ameliorates-drought-stress-induced-damage-in-medicago-sativa-plants-by-modulating-nitro-oxidative-homeostasis-and-proline-metabolism
#9
Chrystalla Antoniou, Giannis Chatzimichail, Rafaella Xenofontos, Giannis Pavlou, Evangelia Panagiotou, Anastasis Christou, Vasileios Fotopoulos
Recent reports have uncovered the multifunctional role of melatonin in plant physiological responses under optimal and sub-optimal environmental conditions. In this study, we explored whether melatonin pretreatment could provoke priming effects in alfalfa (Medicago sativa L.) plants subsequently exposed to prolonged drought stress (7 days), by withholding watering. Results revealed that the rhizospheric application of melatonin (10 μM) remarkably enhanced the drought tolerance of alfalfa plants, as evidenced by the observed plant tolerant phenotype, as well as by the higher levels of chlorophyll fluorescence and stomatal conductance, compared with non-treated drought-stressed plants...
February 22, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28220806/on-the-long-term-stability-of-clines-in-some-metabolic-genes-in-drosophila-melanogaster
#10
Rodrigo Cogni, Kate Kuczynski, Spencer Koury, Erik Lavington, Emily L Behrman, Katherine R O'Brien, Paul S Schmidt, Walter F Eanes
Very little information exists for long-term changes in genetic variation in natural populations. Here we take the unique opportunity to compare a set of data for SNPs in 15 metabolic genes from eastern US collections of Drosophila melanogaster that span a large latitudinal range and represent two collections separated by 12 to 13 years. We also expand this to a 22-year interval for the Adh gene and approximately 30 years for the G6pd and Pgd genes. During these intervals, five genes showed a statistically significant change in average SNP allele frequency corrected for latitude...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28194879/ethanol-production-by-the-hyperthermophilic-archaeon-pyrococcus-furiosus-by-expression-of-bacterial-bifunctional-alcohol-dehydrogenases
#11
Matthew W Keller, Gina L Lipscomb, Diep M Nguyen, Alexander T Crowley, Gerrit J Schut, Israel Scott, Robert M Kelly, Michael W W Adams
Ethanol is an important target for the renewable production of liquid transportation fuels. It can be produced biologically from pyruvate, via pyruvate decarboxylase, or from acetyl-CoA, by alcohol dehydrogenase E (AdhE). Thermophilic bacteria utilize AdhE, which is a bifunctional enzyme that contains both acetaldehyde dehydrogenase and alcohol dehydrogenase activities. Many of these organisms also contain a separate alcohol dehydrogenase (AdhA) that generates ethanol from acetaldehyde, although the role of AdhA in ethanol production is typically not clear...
February 14, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28182052/study-of-nuclear-morphometry-on-cytology-specimens-of-benign-and-malignant-breast-lesions-a-study-of-122-cases
#12
Anamika Kashyap, Manjula Jain, Shailaja Shukla, Manoj Andley
BACKGROUND: Breast cancer has emerged as a leading site of cancer among women in India. Fine needle aspiration cytology (FNAC) has been routinely applied in assessment of breast lesions. Cytological evaluation in breast lesions is subjective with a "gray zone" of 6.9-20%. Quantitative evaluation of nuclear size, shape, texture, and density parameters by morphometry can be of diagnostic help in breast tumor. AIMS: To apply nuclear morphometry on cytological breast aspirates and assess its role in differentiating between benign and malignant breast lesions with derivation of suitable cut-off values between the two groups...
January 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28181469/differences-and-relationships-between-normal-and-atypical-ductal-hyperplasia-ductal-carcinoma-in-situ-and-invasive-ductal-carcinoma-tissues-in-the-breast-based-on-raman-spectroscopy
#13
Bing Han, Ye Du, Ton Fu, Zhimin Fan, Shuping Xu, Chengxu Hu, Lirong Bi, Ting Gao, Haipeng Zhang, Weiqing Xu
The aim of this study was to find the differences and relationships between normal, atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS), and invasive ductal carcinoma (IDC) lesions of the breast based on biochemical characteristics determined by Raman spectroscopy (RS). After collecting 39 frozen sections from patients who underwent surgical resection or mammotome biopsy, nine normal tissues, seven ADH, eight DCIS, and 15 IDC lesions were detected using confocal RS. We then used leave-one-out cross-validation (LOOCV) and radial basis function (RBF) to build a support vector machine (SVM) diagnosis model...
February 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28164835/a-quick-reference-on-hyponatremia
#14
REVIEW
Julien Guillaumin, Stephen P DiBartola
The article focuses on causes of hyponatremia, including hypovolemia, diabetes mellitus and others. Hypovolemia is a major cause of hyponatremia in veterinary medicine. Hypovolemia causes a decrease in effective circulating volume, triggering antidiuretic hormone (ADH) secretion and free water retention, and develops after gastrointestinal losses, renal losses, hemorrhagic shock, hypoadrenocorticism, and other causes of hypovolemia. The article reviews the clinical approach to diagnosing the cause of hyponatremia in critically ill patients, including recognition of the syndrome of inappropriate ADH secretion (SIADH)...
March 2017: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/28164655/serum-alcohol-dehydrogenase-and-aldehyde-dehydrogenase-activity-in-the-course-of-hepatitis-c
#15
Wojciech Jelski, Anna Strumnik, Karolina Orywal, Tadeusz W Lapinski, Magdalena Swiderska, Maciej Szmitkowski
BACKGROUND: Hepatistis C virus (HCV) affects approximately 170 million people, and it is the leading cause of the chronic liver disease. The destruction of liver cells is reflected by an increase of different enzyme activities in the serum. These enzymes include alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), which play a significant role in the metabolism of many biological substances and exist mainly in the liver. In this study we investigated the activity of alcohol dehydrogenase and its isoenzymes and the total activity of ALDH in the sera of patients with hepatitis C...
November 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28118035/is-the-outcome-at-surgery-different-when-flat-epithelial-atypia-and-lobular-neoplasia-are-found-in-association-at-biopsy
#16
Mona El Khoury, Lilia Maria Sanchez, Lucie Lalonde, Isabelle Trop, Julie David, Benoît Mesurolle
OBJECTIVES: To assess the impact on the final outcome at surgery of Flat Epithelial Atypia (FEA) when found concomitantly with Lobular Neoplasia (LN) in biopsy specimens, compared to pure biopsy proven FEA. METHODS: Institutional review board approval was obtained. A retrospective review of our database between 2009 and 2013 identified eighty-one women (mean age 54, range 38-90) with 81 FEA biopsy-proven lesions. These were pure or associated with LN only in respectively 59/81 (73%) and 22/81 (27%)...
January 24, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28112389/kinetic-insights-into-%C3%AF%C2%B5-caprolactone-synthesis-improvement-of-an-enzymatic-cascade-reaction
#17
Christian Scherkus, Sandy Schmidt, Uwe T Bornscheuer, Harald Gröger, Selin Kara, Andreas Liese
A computational approach for the simulation and prediction of a linear three-step enzymatic cascade for the synthesis of ϵ-caprolactone (ECL) coupling an alcohol dehydrogenase (ADH), a cyclohexanone monooxygenase (CHMO) and a lipase for the subsequent hydrolysis of ECL to 6-hydroxyhexanoic acid (6-HHA). A kinetic model was developed with an accuracy of prediction for a fed-batch mode of 37% for substrate cyclohexanol (CHL), 90% for ECL and >99% for the final product 6-HHA. Due to a severe inhibition of the CHMO by CHL, a batch synthesis was shown to be less efficient than a fed-batch approach...
January 23, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28111249/metabolic-engineering-of-clostridium-autoethanogenum-for-selective-alcohol-production
#18
Fungmin Liew, Anne M Henstra, Michael Kӧpke, Klaus Winzer, Sean D Simpson, Nigel P Minton
Gas fermentation using acetogenic bacteria such as Clostridium autoethanogenum offers an attractive route for production of fuel ethanol from industrial waste gases. Acetate reduction to acetaldehyde and further to ethanol via an aldehyde: ferredoxin oxidoreductase (AOR) and alcohol dehydrogenase has been postulated alongside the classic pathway of ethanol formation via a bi-functional aldehyde/alcohol dehydrogenase (AdhE). Here we demonstrate that AOR is critical to ethanol formation in acetogens and inactivation of AdhE led to consistently enhanced autotrophic ethanol production (up to 180%)...
January 19, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/28103636/limited-excessive-voluntary-alcohol-drinking-leads-to-liver-dysfunction-in-mice
#19
Scott A Wegner, Katherine A Pollard, Viktor Kharazia, David Darevsky, Luz Perez, Sanjoy Roychowdhury, Allison Xu, Dorit Ron, Laura E Nagy, Frederic Woodward Hopf
BACKGROUND: Liver damage is a serious and sometimes fatal consequence of long-term alcohol intake, which progresses from early-stage fatty liver (steatosis) to later-stage steatohepatitis with inflammation and fibrosis/necrosis. However, very little is known about earlier stages of liver disruption that may occur in problem drinkers, those who drink excessively but are not dependent on alcohol. METHODS: We examined how repeated binge-like alcohol drinking in C57BL/6 mice altered liver function, as compared with a single binge-intake session and with repeated moderate alcohol consumption...
February 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28093366/strategy-for-constructing-vascularized-adipose-units-in-poly-l-glutamic-acid-hydrogel-porous-scaffold-through-inducing-in-situ-formation-of-ascs-spheroids
#20
Kunxi Zhang, Li Song, Jia Wang, Shifeng Yan, Guifei Li, Lei Cui, Jingbo Yin
Vascularization is of great importance to adipose tissue regeneration. Here we introduced a paradigm that using scaffold to induce ASC spheroids, so to promote vascularized adipose tissue regeneration. Poly (l-glutamic acid) (PLGA) was activated by EDC, followed by being cross-linked by Adipic dihydrazide (ADH) to form a homogeneous hydrogel. Lyophilization was then carried out to create porous structure. The PLGA hydrogel scaffold possessed a significant swollen hydrophilic network to weaken cell-scaffold adhesion but drive ASCs to aggregate to form spheroids...
January 16, 2017: Acta Biomaterialia
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