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https://www.readbyqxmd.com/read/29793212/should-we-excise-are-there-any-clinical-or-histologic-features-that-predict-upgrade-in-papillomas-incidental-or-non-incidental
#1
Michael Zaleski, Yun An Chen, Alison L Chetlen, Julie Mack, Liyan Xu, Daleela G Dodge, Dipti M Karamchandani
The clinical decision to excise intraductal papilloma (IDP) without atypia diagnosed on biopsy remains controversial. We sought to establish clinical and histologic predictors (if any) which may predict upgrade in IDP. 296 biopsies (in 278 women) with histologic diagnosis of IDP without atypia were retrospectively identified and placed into Incidental (no corresponding imaging correlate), or Non-incidental (positive imaging correlate) groups. 253/296 (85.5%) cases were non-incidental, and 43/296 (14.5%) were incidental...
May 11, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29791061/antidiuretic-hormone-release-associated-with-increased-intracranial-pressure-independent-of-plasma-osmolality
#2
William J Keller, Elda Mullaj
OBJECTIVE: Introduce and evaluate a new model which explains the release of brain antidiuretic hormone (ADH) independent of plasma osmolality. METHODS: Systematic review and critical analysis of the professional literature. RESULTS: Primary electronic database searches using key terms revealed 57,432 hits. Secondary searches with application of specific inclusion and exclusion criteria and manual inspection for completeness reduced the total number of studies to fourteen (N = 14)...
May 23, 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29782825/characterization-of-an-n-terminal-mutant-of-%C3%AE-a-crystallin-%C3%AE-a-r21q-associated-with-congenital-cataract
#3
Ashutosh S Phadte, Puttur Santhoshkumar, K Krishna Sharma
Several mutations associated with congenital cataracts in human beings target conserved arginine residues in αA-crystallin. The N-terminal region of αA-crystallin is a "mutational hotspot," with multiple cataract-related mutations reported in this region. Two mutations at arginine 21 in the N-terminal domain of αA-crystallin - αA-R21L and αA-R21W have been associated with congenital cataract. A third mutant of R21, αA-R21Q, was recently identified to be associated with congenital cataract in a South Australian family...
May 18, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29779728/association-between-aldehyde-dehydrogenase-2-glu504lys-polymorphism-and-alcoholic-liver-disease
#4
Binxia Chang, Shuli Hao, Longyu Zhang, Miaomiao Gao, Ying Sun, Ang Huang, Guangju Teng, Baosen Li, David W Crabb, Praveen Kusumanchi, Li Wang, Suthat Liangpunsakul, Zhengsheng Zou
BACKGROUND: Only a subset of patients with excessive alcohol use develop alcoholic liver disease (ALD), though the exact mechanism is not completely understood. Once ingested, alcohol is metabolized by 2 key oxidative enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). There are 2 major ALDH isoforms, cytosolic and mitochondrial, encoded by the aldehyde ALDH1 and ALDH2 genes, respectively. The ALDH2 gene was hypothesized to alter genetic susceptibility to alcohol dependence and alcohol-induced liver diseases...
March 20, 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29774955/examining-the-factors-that-are-correlated-with-mindfulness-with-a-focus-on-attention-deficit-hyperactivity-symptoms
#5
Burcu Goksan Yavuz, Mesut Yavuz, Arzu Onal
PURPOSE: We hypothesized that attention deficit hyperactivity symptoms would negatively correlate with the level of mindfulness. DESIGN AND METHOD: Seventy-six subjects referred to the outpatient psychiatry unit and 32 healthy control subjects filled out the Mindful Attention Awareness Scale (MAAS), the Depression Anxiety Stress Scale (DASS), the Adult ADHD Self-Report Scale (ASRS), and the Wender Utah Rating Scale (WURS). FINDINGS: Patients scored higher on ADH symptoms compared to controls (p ≤ ...
May 18, 2018: Perspectives in Psychiatric Care
https://www.readbyqxmd.com/read/29743878/identification-and-functional-characterization-of-a-novel-mutation-in-the-human-calcium-sensing-receptor-that-co-segregates-with-autosomal-dominant-hypocalcemia
#6
Anne Qvist Rasmussen, Niklas Rye Jørgensen, Peter Schwarz
The human calcium-sensing receptor ( CASR ) is the key controller of extracellular Cao 2+ homeostasis, and different mutations in the CASR gene have been linked to different calcium diseases, such as familial hypocalciuric hypercalcemia, severe hyperparathyroidism, autosomal-dominant hypocalcemia (ADH), and Bartter's syndrome type V. In this study, two generations of a family with biochemically and clinically confirmed ADH who suffered severe muscle pain, arthralgia, tetany, abdominal pain, and fatigue were evaluated for mutations in the CASR gene...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29742254/effects-of-three-silane-primers-and-five-adhesive-agents-on-the-bond-strength-of-composite-material-for-a-computer-aided-design-and-manufacturing-system
#7
Ayano Shinohara, Yohsuke Taira, Michino Sakihara, Takashi Sawase
Objective The objective of this study was to evaluate the effects of combinations of silane primers and adhesive agents on the bond strength of a composite block for a computer-aided design and manufacturing system. Material and Methods Three silane primers [Clearfil Ceramic Primer (CP), Super-Bond PZ Primer (PZ), and GC Ceramic Primer II (GP)] were used in conjunction with five adhesive agents [G-Premio Bond (P-Bond), Repair Adhe Adhesive (R-Adhesive), Super-Bond D-Liner Dual (SB-Dual), Super-Bond C&B (SB-Self), and SB-Dual without tributylborane derivative (SB-Light)]...
2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29739065/the-activity-of-alcohol-dehydrogenase-isoenzymes-and-aldehyde-dehydrogenase-in-the-sera-of-patients-with-autoimmune-hepatitis
#8
Wojciech Jelski, Blanka Wolszczak-Biedrzycka, Elzbieta Zasimowicz-Majewska, Karolina Orywal, Joanna Piechota, Tadeusz W Lapinski, Marzena Bednarczyk, Maciej Szmitkowski
BACKGROUND: Autoimmune hepatitis (AIH) is a progressive inflammatory hepatopathy and an important cause of end-stage liver. The liver cells' destruction is reflected by increased activity of different enzymes in the serum. These enzymes include alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), which play a significant role in the metabolism of many biological substances and exist mainly in the liver. In this study we investigated the activity of alcohol dehydrogenase and its isoenzymes and the total activity of ALDH in the sera of patients with autoimmune hepatitis...
April 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29736628/effect-of-technically-relevant-x-ray-doses-on-the-structure-and-function-of-alcohol-dehydrogenase-and-hen-egg-white-lysozyme
#9
Lisa-Marie Schaden, Miriam Wimmer-Teubenbacher, Johannes Poms, Peter Laggner, Karl Lohner, Stephan Sacher, Johannes G Khinast, Sharareh Salar-Behzadi
PURPOSE: The effect of different irradiation doses on the structure and activity of lyophilized powders of Hen Egg-White Lysozyme (HEWL) and alcohol dehydrogenase (ADH) was investigated using these substances as models for robust and sensitive proteins, respectively. Three doses were selected to cover the ranges of radio-sterilization (25kGy), treatment of blood products (25Gy) and annual background radiation dose (approximately 2mGy). The results offer an initial screening of different irradiation doses and support the development of X-ray imaging methods as non-destructive process analytical technology (PAT) tools for detecting the visible particulate matters in such products...
May 7, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29732027/paraoxonase-activity-in-metabolic-syndrome-in-children-and-adolescents
#10
Arati Adhe-Rojekar, Mukund Ramchandra Mogarekar, Mohit Vijay Rojekar
Background: Metabolic syndrome (MetS) is a collection of various interrelated risk factors that appear to have an impact as development of atherosclerotic cardiovascular disease (CVDs). Epidemic of childhood and adolescent's obesity has increased interest in the metabolic syndrome (MS) due to the potential projection into adulthood. The prevalence of MS in adolescents has been estimated to be 6.7% in young adults and 4.2% in adolescents. We aimed to study the MetS in children and adolescents with respect to metabolic changes...
2018: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/29720211/atypical-ductal-hyperplasia-update-on-diagnosis-management-and-molecular-landscape
#11
REVIEW
Tanjina Kader, Prue Hill, Emad A Rakha, Ian G Campbell, Kylie L Gorringe
BACKGROUND: Atypical ductal hyperplasia (ADH) is a common diagnosis in the mammographic era and a significant clinical problem with wide variation in diagnosis and treatment. After a diagnosis of ADH on biopsy a proportion are upgraded to carcinoma upon excision; however, the remainder of patients are overtreated. While ADH is considered a non-obligate precursor of invasive carcinoma, the molecular taxonomy remains unknown. MAIN TEXT: Although a few studies have revealed some of the key genomic characteristics of ADH, a clear understanding of the molecular changes associated with breast cancer progression has been limited by inadequately powered studies and low resolution methodology...
May 2, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29718361/alcohol-metabolism-in-the-progression-of-human-nonalcoholic-steatohepatitis
#12
Hui Li, Erica Toth, Nathan J Cherrington
Alcohol metabolism is a well-characterized biological process that is dominated by the alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) families. Nonalcoholic steatohepatitis (NASH) is the advanced inflammatory stage of nonalcoholic fatty liver disease (NAFLD) and is known to alter the metabolism and disposition of numerous drugs. The purpose of this study was to investigate the alterations in alcohol metabolism processes in response to human NASH progression. Expression and function of ADHs, ALDHs and catalase were examined in normal, steatosis, NASH (fatty) and NASH (not fatty) human liver samples...
April 27, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29715134/the-alcohol-dehydrogenase-isoenzyme-as-a-potential-marker-of-pancreatitis
#13
Wojciech Jelski, Joanna Piechota, Karolina Orywal, Maciej Szmitkowski
BACKGROUND/AIM: Human pancreas parenchyma contains various alcohol dehydrogenase (ADH) isoenzymes and also possesses aldehyde dehydrogenase (ALDH) activity. The altered activities of ADH and ALDH in damaged pancreatic tissue in the course of pancreatitis are reflected in the human serum. The aim of this study was to investigate a potential role of ADH and ALDH as markers for acute (AP) and chronic pancreatitis (CP). PATIENTS AND METHODS: Serum samples were collected for routine biochemical investigations from 75 patients suffering from acute pancreatitis and 70 patients with chronic pancreatitis...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29709905/gastrodin-protects-against-ethanol-induced-liver-injury-and-apoptosis-in-hepg2-cells-and-animal-models-of-alcoholic-liver-disease
#14
Yong Zhang, Can Wang, Bin Yu, Jian-Dong Jiang, Wei-Jia Kong
This study aims to investigate the protective effects of gastrodin (GSTD), a natural compound isolated from the root of Gastrodia elata BL., on ethanol-induced liver injury and apoptosis in HepG2 cells and animal models. For in vitro studies, GSTD was used to pre-treat the cells for 4 h followed by 600 mM of ethanol co-administration for 24 h. Alcoholic liver disease (ALD) of Sprague-Dawley (SD) rats was induced by chronic ethanol-feeding plus a single dose (5 g/kg) of acute ethanol administration, GSTD at different doses were co-administered for 8 weeks...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29697244/investigation-on-sugar-protein-connectivity-in-salmonella-o-antigen-glycoconjugate-vaccines
#15
Gianluigi De Benedetto, Laura Salvini, Stefano Gotta, Paola Cescutti, Francesca Micoli
Invasive nontyphoidal Salmonella disease, for which licensed vaccines are not available, is a leading cause of bloodstream infections in Africa. The O-antigen portion of lipopolysaccharide is a good target for protective immunity. Covalent conjugation of the O-antigen to a carrier protein increases its immunogenicity and O-antigen based glycoconjugate vaccines are currently under investigation at the preclinical stage. We developed a conjugation chemistry for linking O-antigen to CRM197 carrier protein, through sequential insertion of adipic acid dihydrazide (ADH) and adipic acid bis-(N-hydroxysuccinimide) ester (SIDEA) as linkers, without impacting on O-antigen chain epitopes...
April 26, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29697196/abstractband-anl%C3%A3-%C3%A3-lich-der-26-jahrestagung-der-arbeitsgemeinschaft-dermatologische-histologie-adh-11-13-mai-2018-in-mannheim-germany
#16
(no author information available yet)
No abstract text is available yet for this article.
April 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29691385/deep-whole-genome-sequencing-reveals-recent-selection-signatures-linked-to-evolution-and-disease-risk-of-japanese
#17
Yukinori Okada, Yukihide Momozawa, Saori Sakaue, Masahiro Kanai, Kazuyoshi Ishigaki, Masato Akiyama, Toshihiro Kishikawa, Yasumichi Arai, Takashi Sasaki, Kenjiro Kosaki, Makoto Suematsu, Koichi Matsuda, Kazuhiko Yamamoto, Michiaki Kubo, Nobuyoshi Hirose, Yoichiro Kamatani
Understanding natural selection is crucial to unveiling evolution of modern humans. Here, we report natural selection signatures in the Japanese population using 2234 high-depth whole-genome sequence (WGS) data (25.9×). Using rare singletons, we identify signals of very recent selection for the past 2000-3000 years in multiple loci (ADH cluster, MHC region, BRAP-ALDH2, SERHL2). In large-scale genome-wide association study (GWAS) dataset (n = 171,176), variants with selection signatures show enrichment in heterogeneity of derived allele frequency spectra among the geographic regions of Japan, highlighted by two major regional clusters (Hondo and Ryukyu)...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29680943/hypoxia-enhances-lignification-and-affects-the-anatomical-structure-in-hydroponic-cultivation-of-carrot-taproot
#18
Feng Que, Guang-Long Wang, Kai Feng, Zhi-Sheng Xu, Feng Wang, Ai-Sheng Xiong
Hypoxia enhances lignification of carrot root. Hypoxia stress was thought to be one of the major abiotic stresses that inhibiting the growth and development of higher plants. The genes encoding the plant alcohol dehydrogenase (ADH-P) were induced when suffering hypoxia. To investigate the impact of hypoxia on the carrot root growth, carrot plants were cultivated in the hydroponics with or without aeration. Morphological characteristics, anatomical structure, lignin content, and the expression profiles of DcADH-P genes and lignin biosynthesis-related genes were measured...
April 21, 2018: Plant Cell Reports
https://www.readbyqxmd.com/read/29668010/molecular-evolution-and-functional-divergence-of-alcohol-dehydrogenases-in-animals-fungi-and-plants
#19
Claudia E Thompson, Loreta B Freitas, Francisco M Salzano
Alcohol dehydrogenases belong to the large superfamily of medium-chain dehydrogenases/reductases, which occur throughout the biological world and are involved with many important metabolic routes. We considered the phylogeny of 190 ADH sequences of animals, fungi, and plants. Non-class III Caenorhabditis elegans ADHs were seen closely related to tetrameric fungal ADHs. ADH3 forms a sister group to amphibian, reptilian, avian and mammalian non-class III ADHs. In fishes, two main forms are identified: ADH1 and ADH3, whereas in amphibians there is a new ADH form (ADH8)...
2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29666594/association-of-lower-spiritual-well-being-social-support-self-esteem-subjective-well-being-optimism-and-hope-scores-with-mild-cognitive-impairment-and-mild-dementia
#20
Sabrina B Dos Santos, Gabrielli P Rocha, Liana L Fernandez, Analuiza C de Padua, Caroline T Reppold
Introduction: Positive psychology (PP) constructs contribute significantly to a better quality of life for people with various diseases. There are still few studies that have evaluated the evolution of these aspects during the progression of dementia. Objective: To compare the scores for self-esteem, life satisfaction, affect, spirituality, hope, optimism and perceived support network between elderly people with mild cognitive impairment (MCI), mild dementia and moderate dementia and control group. Methods: Cross-sectional study...
2018: Frontiers in Psychology
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