keyword
MENU ▼
Read by QxMD icon Read
search

ADH

keyword
https://www.readbyqxmd.com/read/29148047/plasma-copeptin-levels-in-patients-with-restless-legs-syndrome
#1
S Topaloglu Tuac, S Ozben, M Koseoglu Bitnel, A Koksal, E Kucuksayan, A Hanikoğlu, T Ozben
OBJECTIVES: Copeptin, the C-terminal fragment of antidiuretic hormone, is a new biomarker that has been found to be elevated in several disorders and could be related with prognosis. This study aimed to compare plasma copeptin levels in patients with restless legs syndrome (RLS) with healthy individuals and to investigate whether plasma copeptin levels were associated with the severity of disease. MATERIAL AND METHODS: 41 patients with primary RLS, who were followed in Bakirkoy Psychiatry and Neurology Research and Training Hospital and 41 age- and sex-matched healthy individuals were included into the study...
November 17, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29146271/factors-affecting-the-under-diagnosis-of-atypical-ductal-hyperplasia-diagnosed-by-core-needle-biopsies-a-10-year-retrospective-study-and-review-of-the-literature
#2
Michael Co, Ava Kwong, Tony Shek
INTRODUCTION: Due to the possibility of underestimation, surgical excision is usually offered to patients with atypical ductal hyperplasia (ADH) diagnosed with core needle biopsy (CNB). Here we review the 10-year data of patients with ADH diagnosed by CNB, aiming to identify the factors associated with under-diagnosis. METHODS: Retrospective review of database from 1st Jan 2005 to 31st Dec 2014 was performed; patients with ADH diagnosed by CNB were identified. Diagnosis upgrade rate and its risk factors were evaluated...
November 13, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29143978/production-of-1-2-propanediol-in-photoautotrophic-synechocystis-is-linked-to-glycogen-turn-over
#3
Christian David, Andreas Schmid, Lorenz Adrian, Annegret Wilde, Katja Bühler
We utilized a photoautotrophic organism to synthesize 1,2-propanediol from carbon dioxide and water fueled by light. A synthetic pathway comprising mgsA (methylglyoxal synthase), yqhD (aldehyde reductase), and adh (alcohol dehydrogenase) was inserted into Synechocystis sp. PCC6803 to convert dihydroxyacetone phosphate to methylglyoxal, which is subsequently reduced to acetol and then to 1,2-propanediol. 1,2-propanediol could be successfully produced by Synechocystis, at an approximate rate of 55 µmol h(-1) gCDW(-1) ...
November 16, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29142822/development-of-a-plasmid-based-expression-system-in-clostridium-thermocellum-and-its-use-to-screen-heterologous-expression-of-bifunctional-alcohol-dehydrogenases-adhes
#4
Shuen Hon, Anthony A Lanahan, Liang Tian, Richard J Giannone, Robert L Hettich, Daniel G Olson, Lee R Lynd
Clostridium thermocellum is a promising candidate for ethanol production from cellulosic biomass, but requires metabolic engineering to improve ethanol yield. A key gene in the ethanol production pathway is the bifunctional aldehyde and alcohol dehydrogenase, adhE. To explore the effects of overexpressing wild-type, mutant, and exogenous adhEs, we developed a new expression plasmid, pDGO144, that exhibited improved transformation efficiency and better gene expression than its predecessor, pDGO-66. This new expression plasmid will allow for many other metabolic engineering and basic research efforts in C...
December 2016: Metabolic Engineering Communications
https://www.readbyqxmd.com/read/29132563/when-does-atypical-ductal-hyperplasia-require-surgical-excision
#5
REVIEW
Jennifer M Racz, Amy C Degnim
Atypical ductal hyperplasia (ADH) is a proliferative, nonobligate precursor breast lesion and a marker of increased risk for breast carcinoma. Surgical excision remains the standard recommendation following a core needle biopsy result consistent with ADH. Recent research suggests that women with no mass lesion or discordance, removal of greater than or equal to 90% of calcifications at the time of core needle biopsy, involvement of less than or equal to 2 terminal duct lobular units, and absence of cytologic atypia or necrosis are likely to have a less than 5% chance of a missed cancer...
January 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29130237/in-situ-forming-oxidised-hyaluronic-acid-adipic-acid-dihydrazide-hydrogel-for-prevention-of-epidural-fibrosis-after-laminectomy
#6
M H Hu, K C Yang, Y H Sun, Y C Chen, S H Yang, F H Lin
Post-operative epidural fibrosis is a biological response after laminectomy that may lead to clinical symptoms, such as radicular pain. An ideal material for prevention of epidural fibrosis should be able to inhibit fibroblast adhesions and reduce formation of scar tissue. An injectable hydrogel would be the material of choice for this purpose, since it could fill an irregular surgical defect completely, gelate in situ and be delivered in a minimally-invasive manner. The objective of this study was to evaluate, in vitro and in vivo, the cytocompatibility and anti-adhesive effect of an oxidised hyaluronic acid/adipic acid dihydrazide (oxi-HA/ADH) hydrogel...
November 13, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/29127708/calcimimetic-and-calcilytic-therapies-for-inherited-disorders-of-the-calcium-sensing-receptor-signalling-pathway
#7
REVIEW
Fadil M Hannan, Mie K Olesen, Rajesh V Thakker
THE CALCIUM-SENSING RECEPTOR (CAS RECEPTOR) PLAYS A PIVOTAL ROLE IN EXTRACELLULAR CALCIUM HOMEOSTASIS AND GERMLINE LOSS- AND GAIN-OF-FUNCTION MUTATIONS CAUSE FAMILIAL HYPOCALCIURIC HYPERCALCAEMIA (FHH) AND AUTOSOMAL DOMINANT HYPOCALCAEMIA (ADH), RESPECTIVELY. CAS RECEPTOR SIGNAL TRANSDUCTION IN THE PARATHYROID GLANDS IS LIKELY REGULATED BY G-PROTEIN SUBUNIT Α11 (GΑ11) AND ADAPTOR-RELATED PROTEIN COMPLEX-2 SIGMA SUBUNIT (AP2Σ), AND RECENT STUDIES HAVE IDENTIFIED GERMLINE MUTATIONS OF THESE PROTEINS AS A CAUSE OF FHH AND/OR ADH...
November 11, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29120608/biochemical-gas-sensors-biosniffers-using-forward-and-reverse-reactions-of-secondary-alcohol-dehydrogenase-for-breath-isopropanol-and-acetone-as-potential-volatile-biomarkers-of-diabetes-mellitus
#8
Po-Jen Chien, Takuma Suzuki, Masato Tsujii, Ming Ye, Isao Minami, Kanako Toda, Hiromi Otsuka, Koji Toma, Takahiro Arakawa, Kouji Araki, Yasuhiko Iwasaki, Kayoko Shinada, Yoshihiro Ogawa, Kohji Mitsubayashi
This study describes two biosniffers to determine breath acetone and isopropanol (IPA) levels and applies them for breath measurement in healthy subjects and diabetic patients. Secondary alcohol dehydrogenase (S-ADH) can reduce acetone and oxidize nicotinamide adenine dinucleotide (NADH to NAD(+)) in a weak acid environment. NADH can be excited by 340 nm excitation lights and subsequently emit 490 nm fluorescence. Therefore, acetone can be measured by the decrease in NADH fluorescence intensity. S-ADH can also oxidize IPA and reduce NAD(+) to NADH when it is in an alkaline environment...
November 9, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29111032/injectable-hydrogels-based-on-the-hyaluronic-acid-and-poly-%C3%AE-glutamic-acid-for-controlled-protein-delivery
#9
Xuebin Ma, Tingting Xu, Wei Chen, Hongye Qin, Bo Chi, Zhiwen Ye
Injectable hydrogels have great potential in minimally invasive delivery. In this work, novel injectable hydrogels were prepared via self-crosslinking of aldehyde hyaluronic acid (HA-CHO) and hydrazide-modified poly (γ-glutamic acid) (γ-PGA-ADH) for proteins delivery. The HA/γ-PGA hydrogels could be formed in situ as fast as 9s with high swelling ratios. Rheological properties illustrated a wide processing range and good mechanical properties, which were reflected by broad linear viscoelastic region and higher threshold shear stress (σc) and storage modulus (G')...
January 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29108627/co-expression-of-an-alcohol-dehydrogenase-and-a-cyclohexanone-monooxygenase-for-cascade-reactions-facilitates-the-regeneration-of-the-nadph-cofactor
#10
Anna Kohl, Vishnu Srinivasamurthy, Dominique Böttcher, Johannes Kabisch, Uwe T Bornscheuer
The introduction of a three-enzyme cascade (comprising a cyclohexanone monooxygenase (CHMO), an alcohol dehydrogenase (ADH) and a lipase (CAL-A)) for the production of oligo-ε-caprolactone provided self-sufficiency with respect to NADPH-cofactor regeneration and reduced inhibiting effects on the central CHMO enzyme. For further optimization of cofactor regeneration, now a co-expression of CHMO and ADH in E. coli using a Duet™ vector was performed. This led to higher conversion values of the substrate cyclohexanol in whole-cell biocatalysis compared to an expression of both enzymes from two separate plasmids...
January 2018: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/29102627/the-anti-stresses-capability-of-grp78-in-penaeus-monodon-evidence-from-in-vitro-and-in-vivo-studies
#11
Lili Li, Pengfei Wang, Chao Zhao, Lihua Qiu
Glucose-regulated protein 78 (GRP78) is an important member of the heat shock protein 70 (HSP70) family, which plays important roles in the response to stimulation from various external environmental stimuli. In this study, the full-length cDNA of GRP78 (PmGRP78) was cloned from Penaeus monodon. The qRT-PCR analysis showed that PmGRP78 was ubiquitously expressed in all the tested shrimp tissues, and the expression pattern of PmGRP78 in the gill and hepatopancreas tissues after a pH challenge, osmotic stress, and heavy metal exposure was also detected...
November 2, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29100516/crispr-interference-guided-multiplex-repression-of-endogenous-competing-pathway-genes-for-redirecting-metabolic-flux-in-escherichia-coli
#12
Seong Keun Kim, Wonjae Seong, Gui Hwan Han, Dae-Hee Lee, Seung-Goo Lee
BACKGROUND: Multiplex control of metabolic pathway genes is essential for maximizing product titers and conversion yields of fuels, chemicals, and pharmaceuticals in metabolic engineering. To achieve this goal, artificial transcriptional regulators, such as clustered regularly interspaced short palindromic repeats (CRISPR) interference (CRISPRi), have been developed to specifically repress genes of interest. RESULTS: In this study, we deployed a tunable CRISPRi system for multiplex repression of competing pathway genes and, thus, directed carbon flux toward production of molecules of interest in Escherichia coli...
November 3, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/29072876/identification-of-glyceraldehyde-3-phosphate-and-alcohol-dehydrogenases-as-autoantigens-in-doberman-hepatitis
#13
H Dyggve, H Jarva, T Spillmann, M Speeti, S Meri
An autoimmune background is suspected for Doberman hepatitis (DH). It is based on the finding of mononuclear cell infiltrates in the liver, strong female bias, association to the homozygous risk factor dog leucocyte antigen (DLA) allele DRB1*00601 and aberrant major histocompatibility complex (MHC) class II expression on hepatocytes that correlates with the degree of inflammation in the liver. The aim of this study was to search for autoantibodies against liver-related antigens associated with DH. Twenty-five Dobermans with subclinical DH (SDH), 13 that clinically manifest DH (CDH) and 17 healthy controls were studied...
September 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29072858/flat-epithelial-atypia-conservative-management-of-patients-without-residual-microcalcifications-post-vacuum-assisted-breast-biopsy
#14
Simone Schiaffino, Licia Gristina, Alessandro Villa, Simona Tosto, Francesco Monetti, Franca Carli, Massimo Calabrese
OBJECTIVE: To determine the malignancy rate (defined in this study as stability or absence of malignancy developed on close imaging follow-up post-biopsy) of conservative management in patients with a vacuum-assisted breast biopsy (VAB) diagnosis of flat epithelial atypia (FEA), performed on single group of microcalcifications, completely removed during procedure. METHODS: This is a retrospective, monocentric, observational study, approved by IRB. Inclusion criteria were: VAB performed on a single group of microcalcifications; the absence of residual calcifications post-VAB; diagnosis of isolated FEA as the most advanced proliferative lesion; radiological follow-up at least of 12 months...
November 9, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29069348/photophase-duration-affects-immature-black-soldier-fly-diptera-stratiomyidae-development
#15
Leslie A Holmes, Sherah L VanLaerhoven, Jeffery K Tomberlin
This study tested the effect of photophase duration on black soldier fly, Hermetia illucens (L.; Diptera: Stratiomyidae), development. Successful larval eclosion, development time and adult emergence were measured for individuals exposed to 0 h, 8 h, and 12 h of light, at approximately 27°C and 70% relative humidity. Accumulated degree hours (ADH) were calculated to correct for differences in temperature across treatments. Larvae successfully eclosed in all treatments, with larvae in 12 h light requiring 5...
October 23, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/29056667/hyponatremia-as-the-presenting-feature-of-a-pituitary-abscess-in-a-calf
#16
Jamie L Stewart, Maria C Bates, B Wade Edwards, Brian M Aldridge
A 2-month-old Simmental heifer presented for acute onset of neurological behavior. Laboratory tests confirmed the presence of hyponatremia, hypochloremia, and hypokalemia that improved with intravenous fluid therapy. Despite an initial cessation of neurological signs, symptoms re-emerged, and the heifer was euthanized due to poor prognosis. A pituitary abscess (Trueperella pyogenes) was observed on gross necropsy, suggesting that the effects of panhypopituitarism (inappropriate anti-diuretic hormone (ADH), adrenocorticotropic hormone (ACTH), and/or thyroid-stimulating hormone (TSH) secretion) may have resulted in the clinical findings...
February 6, 2017: Veterinary Sciences
https://www.readbyqxmd.com/read/29044893/tsynthetic-klebsiella-pneumoniae-shewanella-oneidensis-consortium-enables-glyc-erol-fed-high-performance-microbial-fuel-cells
#17
Feng Li, Changji Yin, Liming Sun, Yuanxiu Li, Xuewu Guo, Hao Song
Microbial fuel cell (MFC) is an eco-friendly bio-electrochemical system that uses mi-croorganism as biocatalyst to convert biomass into electricity. Glycerol, as a waste in the biodiesel refinery processes, is an appealing substrate for MFC. Nevertheless, glycerol cannot be utilized as carbon source by well-known exoelectrogens such as Shewanella oneidensis. Herein, to generate electricity by rapidly harnessing glycerol, we rationally constructed a Klebsiella pneumoniae-Shewanella oneidensis microbial consortium to efficiently harvest electricity from glycerol, in which K...
October 18, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29044328/carbon-dioxide-methanol-conversion-cycle-based-on-cascade-enzymatic-reactions-supported-on-superparamagnetic-nanoparticles
#18
Caterina G C Marques, Leandro H Andrade, Henrique E Toma
The conversion of carbon dioxide into important industrial feedstock is a subject of growing interest in modern society. A possible way to achieve this goal is by carrying out the CO2/methanol cascade reaction, allowing the recycle of CO2 using either chemical catalysts or enzymes. Efficient and selective reactions can be performed by enzymes; however, due to their low stability, immobilization protocols are required to improve their performance. The cascade reaction to reduce carbon dioxide into methanol has been explored by the authors, using, sequentially, alcohol dehydrogenase (ADH), formaldehyde dehydrogenase (FalDH), and formate dehydrogenase (FDH), powered by NAD+/NADH and glutamate dehydrogenase (GDH) as the co-enzyme regenerating system...
October 16, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29043790/emissive-synthetic-cofactors-an-isomorphic-isofunctional-and-responsive-nad-analogue
#19
Alexander R Rovira, Andrea Fin, Yitzhak Tor
The synthesis, photophysics, and biochemical utility of a fluorescent NAD(+) analogue based on an isothiazolo[4,3-d]pyrimidine core (N(tz)AD(+)) are described. Enzymatic reactions, photophysically monitored in real time, show N(tz)AD(+) and N(tz)ADH to be substrates for yeast alcohol dehydrogenase and lactate dehydrogenase, respectively, with reaction rates comparable to that of the native cofactors. A drop in fluorescence is seen as N(tz)AD(+) is converted to N(tz)ADH, reflecting a complementary photophysical behavior to that of the native NAD(+)/NADH...
October 27, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29040892/majority-of-flat-epithelial-atypia-diagnosed-on-biopsy-do-not-require-surgical-excision
#20
Patrick Mun Yew Chan, Niketa Chotai, Eileen Shujuan Lai, Pei Yi Sin, Juliana Chen, Sarah Qinghui Lu, Mui Heng Goh, Bee Kiang Chong, Bernard Chi Shern Ho, Ern Yu Tan
BACKGROUND: Borderline risk lesions such as flat epithelial atypia (FEA) are increasingly being diagnosed on biopsy. The need for surgery is being debated. In this study, we determined the frequency of histological upgrade following a diagnosis of FEA on biopsy and evaluated potential predictive factors. METHODS: Retrospective review was done of 194 women who underwent biopsy of indeterminate lesions (total 195 lesions) that were diagnosed as FEA. The review covered a 10-year period...
October 14, 2017: Breast: Official Journal of the European Society of Mastology
keyword
keyword
24523
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"