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Rejuvenation factors and plasma

Naema Y Elnehrawy, Zeinab A Ibrahim, Azza M Eltoukhy, Hala M Nagy
BACKGROUND: Platelet-rich plasma (PRP) is considered as a growing modality for tissue regeneration and a developing research area for clinicians and researchers. PRP injection treatment provides supraphysiological concentrations of growth factors that may help in accelerated tissue remodeling and regeneration. AIM OF THE STUDY: To evaluate the efficacy and safety of single autologous PRP intradermal injection for treatment of facial wrinkles and for facial rejuvenation...
July 29, 2016: Journal of Cosmetic Dermatology
Gino Rigotti, Luiz Charles-de-Sá, Natale Ferreira Gontijo-de-Amorim, Christina Maeda Takiya, Paola Romina Amable, Radovan Borojevic, Donatella Benati, Paolo Bernardi, Andrea Sbarbati
BACKGROUND: In a previous study, the authors demonstrated that treatment with expanded adipose-derived stem cells or stromal vascular fraction (SVF)-enriched fat modify the pattern of the dermis in human beings, representing a skin rejuvenation effect. Considering that expanded stem cells require a cell factor, the authors wanted to assess similar results by replacing them with platelet-rich plasma (PRP), which is easier to obtain and for which an empirical regenerative effect has been already described...
March 2016: Aesthetic Surgery Journal
Katharine E Johnson, Yogeshwar Makanji, Peter Temple-Smith, Emily K Kelly, Peter A Barton, Sara L Al-Musawi, Thomas D Mueller, Kelly L Walton, Craig A Harrison
Mature TGF-β proteins are used in vivo to promote bone growth, combat obesity, reverse fibrosis and pulmonary arterial hypertension, and as potential rejuvenation factors. However, the serum half-life of this family of growth factors is short (∼5 min), limiting their therapeutic potential. Because TGF-β proteins are normally secreted from cells with their prodomains attached, we considered whether these molecules could extend the in vivo half-life and activity of their respective growth factors. Using activin A as a model ligand, we initially modified the cleavage site between the pro- and mature domains to ensure complete processing of the activin A precursor...
February 15, 2016: Molecular and Cellular Endocrinology
Joseph M Castellano, Elizabeth D Kirby, Tony Wyss-Coray
In the modern medical era, more diverse and effective treatment options have translated to increased life expectancy. With this increased life span comes increased age-associated disease and the dire need to understand underlying causes so that therapies can be designed to mitigate the burden to health and the economy. Aging exacts a seemingly inevitable multisystem deterioration of function that acts as a risk factor for a variety of age-related disorders, including those that devastate organs of limited regenerative potential, such as the brain...
October 2015: JAMA Neurology
Michael S Leo, Alur S Kumar, Raj Kirit, Rajyalaxmi Konathan, Raja K Sivamani
Platelet-rich plasma (PRP) is a highly concentrated autologous solution of plasma prepared from a patient's own blood. PRP contains platelets that are purported to release numerous growth factors that may be valuable in numerous dermatologic applications. Here, we review systematically the clinical cosmetic applications of PRP including: androgenetic alopecia, scar revision, acne scars, skin rejuvenation, dermal augmentation, and striae distensae to understand the potential and best practices for PRP use. A systematic search was conducted on three databases: Pubmed, Embase, and Web of Science...
December 2015: Journal of Cosmetic Dermatology
B Bioulac, W Heppt, M Heppt
BACKGROUND: Aging is a complex process driven by endogenous and exogenous stimuli. The distinct cellular and noncellular components of skin and adjacent connective tissue are constantly and irreversibly degraded during aging. OBJECTIVES: The aim was to provide an overview of the biology of skin aging and the therapeutic options for rejuvenation. METHODS: A review of the current literature and a demonstration of autologous fat transfer and platelet-rich plasma (PRP) are presented from a clinical perspective...
July 2015: HNO
Anthony P Sclafani, James Azzi
In facial plastic surgery, the potential for direct delivery of growth factors from platelet preparations has been of particular interest for use in facial rejuvenation, recovery after facial surgery, and wound healing. A literature search was conducted through PubMed for the terms PRP, PRFM, platelet-rich plasma, platelet-rich fibrin matrix, platelet preparations, platelet therapy, growth factors, platelet facial, platelet facial rejuvenation, platelet wound healing, platelet plastic surgery. Articles pertaining to the use of platelet preparations in facial surgery and wound healing in plastic surgery after 2001 were included...
August 2015: Aesthetic Plastic Surgery
Andrew R Mendelsohn, James W Larrick
Brain function declines in aging mammals. Recent work has identified dysregulation of key blood-borne factors whose altered expression during aging diminishes brain function in mice. Increased C-C motif chemokine 11 (CCL11) expression with aging is detrimental to brain function. On the other hand, plasma levels of the trophic factor growth/differentiation factor 11 (GDF11) decrease with aging. Restoration of youthful levels of GDF11 by injection partially restores brain function and neurogenesis by improving endothelial cell function and vasculature...
December 2014: Rejuvenation Research
Dmytro Shytikov, Olexiy Balva, Edouard Debonneuil, Pavel Glukhovskiy, Iryna Pishel
It was reported using various biological models that the administration of blood factors from young animals to old animals could rejuvenate certain functions. To assess the anti-aging effect of young blood we tested the influence of repeated injections of plasma from young mice on the lifespan of aged mice. One group of 36 CBA/Ca female mice aged 10-12 months was treated by repeated injections of plasma from 2- to 4-month-old females (averaging 75-150 μL per injection, once intravenously and once intraperitoneally per week for 16 months)...
October 1, 2014: BioResearch Open Access
Jill Bouchard, Saul A Villeda
The effects of aging were traditionally thought to be immutable, particularly evident in the loss of plasticity and cognitive abilities occurring in the aged central nervous system (CNS). However, it is becoming increasingly apparent that extrinsic systemic manipulations such as exercise, caloric restriction, and changing blood composition by heterochronic parabiosis or young plasma administration can partially counteract this age-related loss of plasticity in the aged brain. In this review, we discuss the process of aging and rejuvenation as systemic events...
January 2015: Journal of Neurochemistry
Sabrina Fabi, Hema Sundaram
Growth factors and cytokines (referred to collectively hereafter as GFs) control cell growth, proliferation, and differentiation via a network of inter and intracellular signaling pathways. There are striking parallels between the pathways involved in skin wound healing and those implicated in photoaging of the skin. In recent years, topical and injectable GFs have emerged as an intriguing therapeutic modality that can be harnessed for aesthetic and medical purposes. This article provides a review of available evidence for the role in skin regeneration of topical GFs, and of injectable GFs contained in autologous platelet-rich plasma (PRP)...
April 2014: Facial Plastic Surgery: FPS
Yoshikazu Yonei
AIM: The purpose of anti-aging medical checkups is to evaluate the functional age of the patient, aiming to prevent functional aging and rejuvenate the functional age. In this study, a comparison of the medical checkup results was conducted in elderly groups with different levels of activities of daily living (ADL). METHODS: There were three groups of subjects; and an independent group that included 43 independently-living subjects (68.9±6.3 years) in the Kyoto Yurin area, a support-requiring group that included 31 subjects (77...
2013: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
Andreea Cristina Niţă, Dana Mihaela Jianu, I P Florescu, Maria Filipescu, O Cobani, S A Jianu, D A Chiriţă, Adriana Bold
BACKGROUND AND AIMS: Nowadays patients want a long-lasting youthful appearance but through a less invasive approach. Our unique approach, "AdipoLASER reJuvenation (ALJ)", involves a variety of less invasive techniques based on simultaneous laser resurfacing, and lipolysis together with adipose tissue graft and redistribution. Recently, we added to this platelet-rich plasma therapy. We conducted a study aiming to emphasize the histopathological changes occurred following these procedures...
2013: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Takeshi Kawazoe, Hak Hee Kim
Platelet-rich plasma (PRP) is a matrix of fibrin and platelets that releases cytokines that are important in wound healing. PRP is produced from the patient's blood and therefore has less risk of allergic reaction and infection. We have obtained PRP with an enhanced white blood cell component (W-PRP) by optimizing the centrifugal separation of PRP from plasma. Here we show that injection of W-PRP into the auricle of nude mice gave greater tissue augmentation compared to PRP. Further augmentation occurred when bFGF was added to W-PRP, and there was a significant increase in the number of α-smooth muscle actin-positive cells in mice treated with W-PRP+bFGF...
2012: Cell Transplantation
Jeong-Hae Choi, Hyun-Wook Lee, Jae-Koo Lee, Jin-woo Hong, Gyoo-cheon Kim
Efforts to employ various types of plasma in the field of skin care have increased consistently because it can regulate many biochemical reactions that are normally unaffected by light-based therapy. One method for skin rejuvenation adopted a high-temperature plasma generator to remove skin epithelial cells. In this case, the catalyzing effects of the plasma were rarely used due to the high temperature. Hence, the benefits of the plasma were not magnified. Recently, many types of low-temperature plasma devices have been developed for medical applications but their detailed functions and working mechanisms are unclear...
March 2013: Archives of Dermatological Research
Bin Liu, Xin-Ying Tan, Yan-Pu Liu, Xiao-Fang Xu, Long Li, Hai-Yan Xu, Ran An, Fa-Ming Chen
Autologous adipose transplantation is rapidly gaining popularity for the restoration of soft tissue defects and lipoatrophy as well as for aesthetic improvements (e.g., facial reconstruction and rejuvenation). However, the current technique is crude that suffers from serious demerits, particularly the long-term unpredictability of volume maintenance due to resorption of the grafted adipose tissue and limited adipogenesis. We hypothesized that the adjuvant use of patient-derived adipose stromal vascular fraction (SVF) and platelet-rich fibrin (PRF) may enhance the overall outcome of autologous fat grafting in plastic and reconstructive surgery...
January 2013: Tissue Engineering. Part C, Methods
Saara Marttila, Juulia Jylhävä, Marko Pesu, Sanna Hämäläinen, Marja Jylhä, Antti Hervonen, Mikko Hurme
Interleukin-7 is a homeostatic cytokine that contributes to the maintenance of the T cell pool. It also has proinflammatory effects and is involved in the pathogenesis of autoimmune diseases. Due to its homeostatic effects, IL-7 has been proposed as a potential rejuvenation factor for the elderly immune system. We analyzed the correlation of plasma IL-7 concentrations and the proportions of different T cell populations in nonagenarians (n=163) participating in the Vitality 90+ study. Young individuals (n=35, aged 19-30years) were used as controls...
December 2011: Experimental Gerontology
Karin Plöderl, Cornelia Strasser, Simone Hennerbichler, Anja Peterbauer-Scherb, Christian Gabriel
Growth factors (GF) contained in platelets are a potential source to improve wound healing by the stimulation and acceleration of soft tissue and bone healing. This resulted in the idea that autologous platelet-rich plasma or platelet lysate (PL) containing high levels of GF might improve healing processes. Today platelet products are already applied in bone and maxillofacial surgery. In recent years, cosmetic surgery and facial rejuvenation procedures are growing steadily. New methods including platelet products aiming to induce non-surgical reduction of wrinkles upon topical injection and to minimize surgical risks in general are developed...
2011: Platelets
Jeong Mok Cho, Yoon Ho Lee, Rong-Min Baek, Sang Woo Lee
BACKGROUND: Platelet-rich plasma (PRP) is researched and used in many clinical fields as it contains an abundance of various growth factors. Recently, a topical injection of PRP has been clinically tried for treatment of photoageing-related skin wrinkles. Nevertheless, there have been only a few studies including objective data or explaining the mechanisms of PRP. Therefore, the authors performed animal experiments to collect laboratory data and to infer the basal mechanism of the effect of PRP on skin rejuvenation...
February 2011: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Anthony P Sclafani
BACKGROUND: Dermal augmentation continues to grow as an aesthetic facial procedure. Many exogenous filler materials rely on an autologous fibrotic response for volume augmentation. AIMS: To evaluate the efficacy of a single injection of autologous platelet-rich fibrin matrix (PRFM) for the correction of deep nasolabial folds (NLFs). PATIENTS/METHODS: Whole blood was obtained from 15 adults, and an activated autologous PRFM produced using a proprietary system (Selphyl; Aesthetic Factors, Inc...
March 2010: Journal of Cosmetic Dermatology
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