keyword
https://read.qxmd.com/read/38534738/effects-of-blood-derived-products-on-cellular-senescence-and-inflammatory-response-a-study-on-skin-rejuvenation
#1
JOURNAL ARTICLE
Harald Kühnel, Markus Pasztorek, Olga Kuten-Pella, Karina Kramer, Christoph Bauer, Zsombor Lacza, Stefan Nehrer
Blood-derived products, such as citrate platelet-rich plasma (CPRP) and hyperacute serum (HAS), are recognized for their rich growth factor content. When human dermal fibroblast (HDF) cells are exposed to combined mitogenic and DNA-damaging stimuli, it can lead to an increased burden of senescent cells and a modified senescence-associated secretory phenotype. In this study, the senescent state was comprehensively assessed through various methods, including phosphorylated histone H2AX (γH2AX) staining, p21 and p16 q-PCR, p21-western blot, growth curves, and senescence-associated ß-galactosidase staining...
February 28, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38518624/the-emerging-role-of-biostimulators-as-an-adjunct-in-facial-rejuvenation-a-systematic-review
#2
REVIEW
Sean M Fisher, Zachary Borab, David Weir, Rod J Rohrich
INTRODUCTION: Facial aging has long been an area of focus in esthetic surgery. It is the consequence of physiologic and environmental factors, with a trend toward non-surgical modalities. Although volume augmentation has long been a focus of non-surgical facial rejuvenation, there is emerging interest in the use of biostimulators to induce physiologic changes in the skin. This article aimed to provide an overview of this class of therapies. METHODS: A systematic review regarding the clinical use of biostimulatory agents including platelet-rich plasma (PRP), platelet-rich fibrin (PRF), poly-L-lactic acid (PLLA) and calcium hydroxylapatite (CaHA) in facial rejuvenation was performed using PubMed databases...
March 6, 2024: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://read.qxmd.com/read/38440028/enhancement-of-ovarian-reserve-and-oocyte-quality-after-platelet-rich-plasma-instillation-in-a-woman-with-diminished-anti-m%C3%A3-llerian-hormone
#3
Jarul Shrivastava, Akash More, Virul Shrivastava, Namrata Choudhary, Deepti Shrivastava
Platelet-rich plasma (PRP) is a concentrated platelet preparation known for its regenerative properties due to the various growth factors it contains. Its application in the medical field, including dentistry, gynecology, and plastic surgery, has surged. In obstetrics and gynecology, PRP has shown promise in improving low libido, vaginal rejuvenation, ovarian reserve, and endometrial receptivity. This study presents a 29-year-old woman experiencing primary infertility attributed to low levels of anti-Müllerian hormone alongside the presence of asthenozoospermia in her husband's semen...
February 2024: Curēus
https://read.qxmd.com/read/38430547/young-plasma-rejuvenates-blood-dna-methylation-profile-extends-mean-lifespan-and-improves-physical-appearance-in-old-rats
#4
JOURNAL ARTICLE
Priscila Chiavellini, Marianne Lehmann, Maria D Gallardo, Martina Canatelli Mallat, Diana C Pasquini, Joseph A Zoller, Juozas Gordevicius, Mauricio Girard, Ezequiel Lacunza, Claudia B Herenu, Steve Horvath, Rodolfo G Goya
There is converging evidence that young blood conveys cells, vesicles and molecules able to revitalize function and restore organ integrity in old individuals. We assessed the effects of young plasma on the lifespan, epigenetic age and healthspan of old female rats. Beginning at 25.6 months of age, a group of 9 rats (group T) was i.p. injected with plasma from young rats until their natural death. A group of 8 control rats of the same age received no treatment (group C). Blood samples were collected every other week...
March 2, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38423539/intraovarian-platelet-rich-plasma-injection-and-ivf-outcomes-in-patients-with-poor-ovarian-response-a-double-blind-randomized-controlled-trial
#5
JOURNAL ARTICLE
G Barrenetxea, R Celis, J Barrenetxea, E Martínez, M De Las Heras, O Gómez, O Aguirre
STUDY QUESTION: Does platelet-rich plasma (PRP) intraovarian injection increase the number of retrieved oocytes in successive ovarian punctions among patients with poor ovarian reserve (POR)? SUMMARY ANSWER: The injection of PRP increases the number of retrieved oocytes without increasing the quality of developed blastocysts. WHAT IS KNOWN ALREADY: Management of women with reduced ovarian response to stimulation is one of the significant challenges in reproductive medicine...
February 29, 2024: Human Reproduction
https://read.qxmd.com/read/38275368/platelet-rich-plasma-prp-in-dermatology-cellular-and-molecular-mechanisms-of-action
#6
REVIEW
Denisa Vladulescu, Lucian G Scurtu, Anca Angela Simionescu, Francesca Scurtu, Marco I Popescu, Olga Simionescu
Platelet-rich plasma (PRP) therapy has gained attention in the scientific field due to its potential regenerative effects and great benefit-risk ratio. This review extensively explores the most studied mechanisms of this therapy according to the etiopathogenesis of skin diseases: cellular proliferation, matrix formation, regulation of inflammation, angiogenesis, collagen synthesis, and the remodeling of new tissue. Moreover, it draws on newly reported and lesser-known effects of PRP: its anti-apoptotic effects, immunological suppression, decrease in melanin synthesis, anti-microbial effects, overexpression of miR-155, antioxidant effects, and their involved pathways...
December 19, 2023: Biomedicines
https://read.qxmd.com/read/38275367/the-synergistic-effects-of-hyaluronic-acid-and-platelet-rich-plasma-for-patellar-chondropathy
#7
REVIEW
Fábio Ramos Costa, Márcia da Silva Santos, Rubens Andrade Martins, Cláudia Bruno Costa, Paulo César Hamdan, Marcos Britto Da Silva, Gabriel Ohana Marques Azzini, Luyddy Pires, Zartur Menegassi, Gabriel Silva Santos, José Fábio Lana
Musculoskeletal disorders are increasingly prevalent worldwide, causing significant socioeconomic burdens and diminished quality of life. Notably, patellar chondropathy (PC) is among the most widespread conditions affecting joint structures, resulting in profound pain and disability. Hyaluronic acid (HA) and platelet-rich plasma (PRP) have emerged as reliable, effective, and minimally invasive alternatives. Continuous research spanning from laboratory settings to clinical applications demonstrates the numerous advantages of both products...
December 19, 2023: Biomedicines
https://read.qxmd.com/read/38040732/supernatant-of-activated-platelet-rich-plasma-rejuvenated-aging-induced-hyposalivation-in-mouse
#8
JOURNAL ARTICLE
Sungryeal Kim, Jeong Mi Kim, Eun Jeong Jeon, Ji Won Kim, Mi Eun Choi, Jin-Mi Park, Jeong-Seok Choi
Hyposalivation is a common complaint among the elderly, but no established treatment prevents age-induced hyposalivation. Platelet derivatives such as platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and plasma rich in growth factor (PRGF), are used widely in different areas of regenerative medicine to enhance the wound healing processes. This study examined whether the local injection of the supernatant of activated PRP (saPRP) into the salivary gland (SG) could help prevent aging-induced SG dysfunction and explored the mechanisms responsible for the protective effects on the SG hypofunction...
December 1, 2023: Scientific Reports
https://read.qxmd.com/read/37903326/a-pilot-randomized-single-blind-controlled-study-evaluating-the-use-of-platelet-rich-plasma-prp-for-hand-skin-rejuvenation
#9
JOURNAL ARTICLE
Thais Pincelli, Suha Zawawi, Shane Shapiro, Michael G Heckman, Alexander P Hochwald, Cheryl Desmond, Jennifer Arthurs, Leila Tolaymat, Antonio Forte, Alison Bruce
BACKGROUND: The presence of various growth factors in platelets makes platelet rich plasma a powerful tool in the stimulation of collagen regeneration in aging skin. The main objective of this study was to determine efficacy and safety of platelet rich plasma compared to saline solution in women with aging skin of the hands. METHODS: In this prospective, randomized clinical trial, eighteen women with hand aging received PRP injections every 4 weeks into the unilateral dorsal hand for 12 weeks total; with saline injections into the contralateral hand in a randomized, controlled, single-blind fashion...
October 30, 2023: Plastic and Reconstructive Surgery
https://read.qxmd.com/read/37843317/perspectives-and-challenges-in-lip-rejuvenation-a-systematic-review
#10
JOURNAL ARTICLE
N Tabassum, V Chowdary Jasthi, A Al Salem, S M Kumar, M Muayad Alshaban, D M Alrashd, L Al Nasser, S Ahmed
OBJECTIVE: There is an abundance of information on facelifts, blepharoplasties, rhinoplasty, and other cosmetic surgical procedures for the upper third of the face, but little is known about perioral lip rejuvenation. The aim of this article is to examine the existing literature on lip rejuvenation and perioral procedures related to lip rejuvenation. Additionally, this article aims to highlight the importance of addressing perioral areas alongside lip rejuvenation procedures, rather than solely focusing on lip rejuvenation...
October 2023: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/37627872/anti-aging-potential-of-platelet-rich-plasma-prp-evidence-from-osteoarthritis-oa-and-applications-in-senescence-and-inflammaging
#11
JOURNAL ARTICLE
James Vun, Neelam Iqbal, Elena Jones, Payal Ganguly
Aging and age-related changes impact the quality of life (QOL) in elderly with a decline in movement, cognitive abilities and increased vulnerability towards age-related diseases (ARDs). One of the key contributing factors is cellular senescence, which is triggered majorly by DNA damage response (DDR). Accumulated senescent cells (SCs) release senescence-associated secretory phenotype (SASP), which includes pro-inflammatory cytokines, matrix metalloproteinases (MMPs), lipids and chemokines that are detrimental to the surrounding tissues...
August 21, 2023: Bioengineering
https://read.qxmd.com/read/37610839/the-rejuvenating-influence-of-young-plasma-on-aged-intestine
#12
JOURNAL ARTICLE
Taha Ceylani, Hikmet Taner Teker, Seda Keskin, Gizem Samgane, Eda Acikgoz, Rafig Gurbanov
This study aims to investigate the effects of plasma exchange on the biomolecular profiles and histology of ileum and colon tissues in young and aged Sprague-Dawley male rats. Fourier transform infrared (FTIR) spectroscopy, linear discriminant analysis and support vector machine (SVM) techniques were employed to analyse the lipid, protein, and nucleic acid indices in young and aged rats. Following the application of young plasma, aged rats demonstrated biomolecular profiles similar to those of their younger counterparts...
August 23, 2023: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/37591239/atlas-of-the-aging-mouse-brain-reveals-white-matter-as-vulnerable-foci
#13
JOURNAL ARTICLE
Oliver Hahn, Aulden G Foltz, Micaiah Atkins, Blen Kedir, Patricia Moran-Losada, Ian H Guldner, Christy Munson, Fabian Kern, Róbert Pálovics, Nannan Lu, Hui Zhang, Achint Kaur, Jacob Hull, John R Huguenard, Sebastian Grönke, Benoit Lehallier, Linda Partridge, Andreas Keller, Tony Wyss-Coray
Aging is the key risk factor for cognitive decline, yet the molecular changes underlying brain aging remain poorly understood. Here, we conducted spatiotemporal RNA sequencing of the mouse brain, profiling 1,076 samples from 15 regions across 7 ages and 2 rejuvenation interventions. Our analysis identified a brain-wide gene signature of aging in glial cells, which exhibited spatially defined changes in magnitude. By integrating spatial and single-nucleus transcriptomics, we found that glial aging was particularly accelerated in white matter compared with cortical regions, whereas specialized neuronal populations showed region-specific expression changes...
September 14, 2023: Cell
https://read.qxmd.com/read/37552316/aging-and-age-related-diseases-with-a-focus-on-therapeutic-potentials-of-young-blood-plasma
#14
REVIEW
Leila Hosseini, Parviz Shahabi, Ali Fakhari, Hamid Soltani Zangbar, Fatemehsadat Seyedaghamiri, Jafar Sadeghzadeh, Nasrin Abolhasanpour
Aging is accompanied by alterations in the body with time-related to decline of physiological integrity and functionality process, responsible for increasing diseases and vulnerability to death. Several ages associated with biomarkers were observed in red blood cells, and consequently plasma proteins have a critical rejuvenating role in the aging process and age-related disorders. Advanced age is a risk factor for a broad spectrum of diseases and disorders such as cardiovascular diseases, musculoskeletal disorders and liver, chronic kidney disease, neurodegenerative diseases, and cancer because of loss of regenerative capacity, correlated to reduced systemic factors and raise of pro-inflammatory cytokines...
August 8, 2023: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/37551981/heterochronic-plasma-transfer-experimental-design-considerations-and-technical-challenges
#15
JOURNAL ARTICLE
Victor A Ansere, Matthew P Bubak, Benjamin F Miller, Willard M Freeman
Experimental approaches such as Heterochronic Plasma Transfer (HPT) provides insights into the aging process and helps identify factors that impact aging, with the aim of developing anti-aging therapies. HPT involves the transfer of plasma from an animal of one age to an animal of a different age and highlights the effects of the systemic environment on aging. Despite its importance as an aging research tool, HPT is not without limitations and HPT experiments across various studies differ in key experimental designs considerations, presenting a challenge in obtaining comparable outcomes...
August 8, 2023: Rejuvenation Research
https://read.qxmd.com/read/37522505/efficacy-of-photo-thermal-bioactivated-platelet-rich-plasma-for-skin-biostimulation-in-patients-not-eligible-for-other-medical-aesthetic-treatment-a-pilot-study
#16
JOURNAL ARTICLE
Carlota Hernández Sanz, Hernán Pinto
PURPOSE: To evaluate the efficacy and safety of photothermal bioactivated platelet-rich plasma for reducing laxity in facial rejuvenation in patients not eligible for other aesthetic treatments due to several comorbidities. METHODS: A prospective, nonrandomized study was conducted. Efficacy was assessed through a satisfaction scale and the Facial Laxity Rating Scale. Safety assessments were based on the data of all adverse events and the visual analog pain scale...
July 2023: Skin Research and Technology
https://read.qxmd.com/read/37511761/mtor-inhibition-via-low-dose-pulsed-rapamycin-with-intraovarian-condensed-platelet-cytokines-an-individualized-protocol-to-recover-diminished-reserve
#17
JOURNAL ARTICLE
E Scott Sills, Conor Harrity, Samuel H Wood, Seang Lin Tan
No major breakthroughs have entered mainstream clinical fertility practice since egg donation and intracytoplasmic sperm injection decades ago, and oocyte deficits secondary to advanced age continue as the main manifestation of diminished ovarian reserve. In the meantime, several unproven IVF 'accessories' have emerged including so-called ovarian rejuvenation which entails placing fresh autologous platelet-rich plasma (PRP) directly into ovarian tissue. Among cellular responses attributed to this intervention are reduced oxidative stress, slowed apoptosis and improved metabolism...
July 17, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37261667/improving-autologous-fat-grafting-in-regenerative-surgery-through-stem-cell-assisted-lipotransfer
#18
REVIEW
Benjamin Debuc, Nicolas Gendron, Audrey Cras, Jeanne Rancic, Aurélien Philippe, Curtis L Cetrulo, Alexandre G Lellouch, David M Smadja
Autologous fat transplantation -i.e., lipofilling- has become a promising and popular technique in aesthetic and reconstructive surgery with several application such as breast reconstruction, facial and hand rejuvenation. However, the use of this technology is still limited due to an unpredictable and low graft survival rate (which ranges from 25%-80%). A systematic literature review was performed by thoroughly searching 12 terms using the PubMed database. The objective of this study is to present the current evidence for the efficacy of adjuvant regenerative strategies and cellular factors, which have been tested to improve fat graft retention...
June 1, 2023: Stem cell reviews and reports
https://read.qxmd.com/read/37235639/relationships-of-gdf-8-and-11-and-their-antagonists-with-decline-of-grip-strength-among-older-adults-in-the-baltimore-longitudinal-study-of-aging
#19
JOURNAL ARTICLE
Yuko Yamaguchi, Min Zhu, Ruin Moaddel, Elango Palchamy, Luigi Ferrucci, Richard D Semba
Although growth/differentiation factor 11 (GDF11), growth/differentiation factor 8 (GDF8), and their circulating antagonists, which include GDF11 and GDF8 propeptides, follistatin (FST), WFIKKN1, and WFIKKN2, have been shown to influence skeletal muscle and aging in mice, the relationship of these circulating factors with human phenotypes is less clear. This study aimed to characterize the relationship between plasma GDF8, GDF11, FST, WFIKKN1, and WFIKKN2 concentrations with the decline of grip strength in 534 adults, ≥65 years, who participated in the Baltimore Longitudinal Study of Aging and had grip strength measured over time...
May 26, 2023: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/37232716/dermal-fibroblasts-as-the-main-target-for-skin-anti-age-correction-using-a-combination-of-regenerative-medicine-methods
#20
REVIEW
Alla Zorina, Vadim Zorin, Artur Isaev, Dmitry Kudlay, Maria Vasileva, Pavel Kopnin
This article includes the data from current studies regarding the pathophysiological mechanisms of skin aging and the regenerative processes occurring in the epidermis and dermis at the molecular and cellular level, mainly, the key role of dermal fibroblasts in skin regeneration. Analyzing these data, the authors proposed the concept of skin anti-age therapy that is based on the correction of age-related skin changes by stimulating regenerative processes at the molecular and cellular level. The main target of the skin anti-age therapy is dermal fibroblasts (DFs)...
May 1, 2023: Current Issues in Molecular Biology
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