Andrew T McKenzie, Gabriel A Marx, Daniel Koenigsberg, Mary Sawyer, Megan A Iida, Jamie M Walker, Timothy E Richardson, Gabriele Campanella, Johannes Attems, Ann C McKee, Thor D Stein, Thomas J Fuchs, Charles L White, Kurt Farrell, John F Crary
Age-related cognitive impairment is multifactorial, with numerous underlying and frequently co-morbid pathological correlates. Amyloid beta (Aβ) plays a major role in Alzheimer's type age-related cognitive impairment, in addition to other etiopathologies such as Aβ-independent hyperphosphorylated tau, cerebrovascular disease, and myelin damage, which also warrant further investigation. Classical methods, even in the setting of the gold standard of postmortem brain assessment, involve semi-quantitative ordinal staging systems that often correlate poorly with clinical outcomes, due to imperfect cognitive measurements and preconceived notions regarding the neuropathologic features that should be chosen for study...
September 21, 2022: Acta Neuropathologica Communications