keyword
https://read.qxmd.com/read/38234622/early-depressive-manifestations-in-patients-with-dementia-caused-by-alzheimer-s-disease
#1
JOURNAL ARTICLE
Fabiola Sârbu, Mihaela Lungu, Violeta Diana Oprea, Aurelia Romila
Previous studies on the complex interplay between depression and dementia in patients with Alzheimer's disease revealed that early-life depression is a risk factor for dementia. Both depression and dementia appear to share common etiopathological mechanisms. In the present study, a comprehensive retrospective analysis was performed on a study group of patients with dementia suffering from previously diagnosed depression. The aim was to assess potentially relevant clinical and imaging parameters that can be used to characterize depression as a risk factor for dementia in later life...
February 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38132357/the-impact-of-apolipoprotein-e-apoe-epigenetics-on-aging-and-sporadic-alzheimer-s-disease
#2
REVIEW
Madia Lozupone, Vittorio Dibello, Rodolfo Sardone, Fabio Castellana, Roberta Zupo, Luisa Lampignano, Ilaria Bortone, Antonio Daniele, Antonello Bellomo, Vincenzo Solfrizzi, Francesco Panza
Sporadic Alzheimer's disease (AD) derives from an interplay among environmental factors and genetic variants, while epigenetic modifications have been expected to affect the onset and progression of its complex etiopathology. Carriers of one copy of the apolipoprotein E gene ( APOE ) ε4 allele have a 4-fold increased AD risk, while APOE ε4/ε4 -carriers have a 12-fold increased risk of developing AD in comparison with the APOE ε3 -carriers. The main longevity factor is the homozygous APOE ε3/ε3 genotype...
December 15, 2023: Biology
https://read.qxmd.com/read/38085406/multifaceted-neuroprotective-role-of-punicalagin-a-review
#3
REVIEW
Nazia Siddiqui, Alimuddin Saifi, Anurag Chaudhary, Prabhash Nath Tripathi, Ankit Chaudhary, Alok Sharma
Millions of people worldwide are currently afflicted with neurologic conditions like a seizure, depression, stress, Alzheimer's disease, Parkinson's disease, and Huntington's disease. However, the precise etiopathology of these diseases is still unknown. Substantial studies are being conducted to discover more treatments against these disorders because many patients do not experience the therapeutic benefits that would be expected from using existing pharmaceutical strategies. Herbal medicines which have been used in traditional medicine for millennia to treat various neurological problems are also being investigated and scientifically assessed...
December 12, 2023: Neurochemical Research
https://read.qxmd.com/read/37631266/therapeutic-strategies-aimed-at-improving-neuroplasticity-in-alzheimer-disease
#4
REVIEW
María F Colavitta, Francisco J Barrantes
Alzheimer disease (AD) is the most prevalent form of dementia among elderly people. Owing to its varied and multicausal etiopathology, intervention strategies have been highly diverse. Despite ongoing advances in the field, efficient therapies to mitigate AD symptoms or delay their progression are still of limited scope. Neuroplasticity, in broad terms the ability of the brain to modify its structure in response to external stimulation or damage, has received growing attention as a possible therapeutic target, since the disruption of plastic mechanisms in the brain appear to correlate with various forms of cognitive impairment present in AD patients...
July 31, 2023: Pharmaceutics
https://read.qxmd.com/read/37569888/a-brief-review-on-the-potential-of-psychedelics-for-treating-alzheimer-s-disease-and-related-depression
#5
REVIEW
Alexander Pilozzi, Simmie Foster, David Mischoulon, Maurizio Fava, Xudong Huang
Alzheimer's disease (AD), the most common form of senile dementia, is poised to place an even greater societal and healthcare burden as the population ages. With few treatment options for the symptomatic relief of the disease and its unknown etiopathology, more research into AD is urgently needed. Psychedelic drugs target AD-related psychological pathology and symptoms such as depression. Using microdosing, psychedelic drugs may prove to help combat this devastating disease by eliciting psychiatric benefits via acting through various mechanisms of action such as serotonin and dopamine pathways...
August 7, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37561961/a-case-of-corticobasal-syndrome-and-posterior-cortical-atrophy-with-biomarkers-of-alzheimer-disease
#6
JOURNAL ARTICLE
Yoko Sugimura, Toru Baba, Michinori Ezura, Akio Kikuchi, Takafumi Hasegawa, Isao Nagano, Kyoko Suzuki, Atsushi Takeda
Corticobasal syndrome is a clinical entity characterized by asymmetric akinetic rigidity and a variety of higher cortical dysfunction. Predicting background pathology of corticobasal syndrome is rather challenging; however, clinical and neuroimaging findings may provide a clue to its etiopathological origin. Visuospatial dysfunction of posterior cortical atrophy and logopenic-type language impairment indicate the presence of Alzheimer's disease-related pathology, and they provide useful information in distinguishing Alzheimer's disease from other types of corticobasal syndrome...
June 22, 2023: Alzheimer Disease and Associated Disorders
https://read.qxmd.com/read/37408203/a-concise-review-on-oxidative-stress-mediated-ferroptosis-and-cuproptosis-in-alzheimer-s-disease
#7
REVIEW
Xudong Huang
Alzheimer's disease (AD), which was first identified more than a century ago, has become a pandemic that exacts enormous social burden and economic tolls as no measure of combating devastated AD is currently available. Growing etiopathological, genetic, and biochemical data indicate that AD is a heterogeneous, polygenic, multifactorial, and complex disease. However, its exact etiopathology remains to be determined. Numerous experimental data show that cerebral iron and copper dyshomeostasis contribute to Aβ amyloidosis and tauopathy, two neuropathological hallmarks of AD...
May 12, 2023: Cells
https://read.qxmd.com/read/37386455/gauging-innovation-and-health-impact-from-biomedical-research-survey-results-and-interviews-with-recipients-of-eu-funding-in-the-fields-of-alzheimer-s-disease-breast-cancer-and-prostate-cancer
#8
REVIEW
Francesca Pistollato, Ivana Campia, Evangelos P Daskalopoulos, Camilla Bernasconi, Christian Desaintes, Sergio Di Virgilio, Christina Kyriakopoulou, Maurice Whelan, Pierre Deceuninck
Biomedical research on Alzheimer's disease (AD), breast cancer (BC) and prostate cancer (PC) has globally improved our understanding of the etiopathological mechanisms underlying the onset of these diseases, often with the goal to identify associated genetic and environmental risk factors and develop new medicines. However, the prevalence of these diseases and failure rate in drug development remain high. Being able to retrospectively monitor the major scientific breakthroughs and impact of such investment endeavors is important to re-address funding strategies if and when needed...
June 29, 2023: Health Research Policy and Systems
https://read.qxmd.com/read/37051054/clinical-and-genetic-characteristics-in-a-central-southern-chinese-cohort-of-early-onset-alzheimer-s-disease
#9
JOURNAL ARTICLE
Zhihou Liang, Yan Wu, Chuanzhou Li, Zhijun Liu
BACKGROUND: Mutations in the presenilin-1 ( PSEN1 ), presenilin-2 ( PSEN2 ), and amyloid precursor protein ( APP ) genes have been commonly identified in early-onset Alzheimer's disease (EOAD). Some of the mutations in the three causative genes, especially the PSEN1 gene, result in variable phenotypes and exhibit clinical heterogeneity among EOAD families. METHODS: Using next-generation sequencing (NGS), we performed genetic screening in a Chinese cohort of 18 patients with EOAD, consisting of five familial EOAD and 13 sporadic cases...
2023: Frontiers in Neurology
https://read.qxmd.com/read/36998125/acetyl-l-carnitine-and-amyotrophic-lateral-sclerosis-current-evidence-and-potential-use
#10
JOURNAL ARTICLE
Fabiola De Marchi, Sakthipriyan Venkatesan, Massimo Saraceno, Letizia Mazzini, Elena Grossini
BACKGROUND: The management of neurodegenerative diseases can be frustrating for clinicians, given the limited progress of conventional medicine in this context. AIM: For this reason, a more comprehensive, integrative approach is urgently needed. Among various emerging focuses for intervention, the modulation of central nervous system energetics, oxidative stress, and inflammation is becoming more and more promising. METHOD: In particular, electrons leakage involved in the mitochondrial energetics can generate reactive oxygen-free radical-related mitochondrial dysfunction that would contribute to the etiopathology of many disorders, such as Alzheimer's and other dementias, Parkinson's disease, multiple sclerosis, stroke, and amyotrophic lateral sclerosis (ALS)...
March 30, 2023: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/36833274/histone-modifications-in-alzheimer-s-disease
#11
REVIEW
Dalileia Aparecida Santana, Marilia de Arruda Cardoso Smith, Elizabeth Suchi Chen
Since Late-onset Alzheimer's disease (LOAD) derives from a combination of genetic variants and environmental factors, epigenetic modifications have been predicted to play a role in the etiopathology of LOAD. Along with DNA methylation, histone modifications have been proposed as the main epigenetic modifications that contribute to the pathologic mechanisms of LOAD; however, little is known about how these mechanisms contribute to the disease's onset or progression. In this review, we highlighted the main histone modifications and their functional role, including histone acetylation, histone methylation, and histone phosphorylation, as well as changes in such histone modifications that occur in the aging process and mainly in Alzheimer's disease (AD)...
January 29, 2023: Genes
https://read.qxmd.com/read/36797613/herbal-therapeutics-for-alzheimer-s-disease-ancient-indian-medicine-system-from-the-modern-viewpoint
#12
JOURNAL ARTICLE
Shikha Kushwah, Neha Shree Maurya, Sandeep Kushwaha, Luciana Scotti, Aakash Chawade, Ashutosh Mani
Alzheimer's is a chronic neurodegenerative disease where amyloid-beta (Aβ) plaques and neurofibrillary tangles are formed inside the brain. It is also characterized by progressive memory loss, depression, neuroinflammation, and derangement of other neurotransmitters. Due to its complex etiopathology, current drugs have failed to completely cure the disease. Natural compounds have been investigated as an alternative therapy for their ability to treat Alzheimer's disease (AD). Traditional herbs and formulations which are used in the Indian ayurvedic system are rich sources of antioxidant, anti-amyloidogenic, neuroprotective, and anti-inflammatory compounds...
February 16, 2023: Current Neuropharmacology
https://read.qxmd.com/read/36690723/heart-failure-decouples-the-precuneus-in-interaction-with-social-cognition-and-executive-functions
#13
JOURNAL ARTICLE
Matthias L Schroeter, Jannis Godulla, Friederike Thiel, Birol Taskin, Frank Beutner, Vladimir K Dubovoy, Andrej Teren, Julia Camilleri, Simon Eickhoff, Arno Villringer, Karsten Mueller
Aging increases the risk to develop Alzheimer's disease. Cardiovascular diseases might accelerate this process. Our study aimed at investigating the impact of heart failure on brain connectivity using functional magnetic resonance imaging at resting state. Here we show brain connectivity alterations related to heart failure and cognitive performance. Heart failure decreases brain connectivity in the precuneus. Precuneus dysconnectivity was associated with biomarkers of heart failure-left ventricular ejection fraction and N-terminal prohormone of brain natriuretic peptide-and cognitive performance, predominantly executive function...
January 23, 2023: Scientific Reports
https://read.qxmd.com/read/36291618/alzheimer-s-disease-challenges-and-a-therapeutic-opportunity-to-treat-it-with-a-neurotrophic-compound
#14
REVIEW
Narjes Baazaoui, Khalid Iqbal
Alzheimer's disease (AD) is a progressive neurodegenerative disease with an insidious onset and multifactorial nature. A deficit in neurogenesis and synaptic plasticity are considered the early pathological features associated with neurofibrillary tau and amyloid β pathologies and neuroinflammation. The imbalance of neurotrophic factors with an increase in FGF-2 level and a decrease in brain derived neurotrophic factor (BDNF) and neurotrophin 4 (NT-4) in the hippocampus, frontal cortex and parietal cortex and disruption of the brain micro-environment are other characteristics of AD...
October 2, 2022: Biomolecules
https://read.qxmd.com/read/36219531/covid-19-and-neurodegeneration-the-mitochondrial-connection
#15
JOURNAL ARTICLE
Christopher A Denaro, Yara I Haloush, Samuel Y Hsiao, John J Orgera, Teresa Osorio, Lindsey M Riggs, Joshua W Sassaman, Sarah A Williams, Anthony R Monte Carlo, Renata T Da Costa, Andrey Grigoriev, Maria E Solesio
There is still a significant lack of knowledge regarding many aspects of the etiopathology and consequences of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in humans. For example, the variety of molecular mechanisms mediating this infection, and the long-term consequences of the disease remain poorly understood. It first seemed like the SARS-CoV-2 infection primarily caused a serious respiratory syndrome. However, over the last years, an increasing number of studies also pointed towards the damaging effects of this infection has on the central nervous system (CNS)...
November 2022: Aging Cell
https://read.qxmd.com/read/36218057/amyloid-%C3%AE-but-not-tau-induced-neurotoxicity-is-suppressed-by-manuka-honey-via-hsp-16-2-and-skn-1-nrf2-pathways-in-an-in-vivo-model-of-alzheimer-s-disease
#16
JOURNAL ARTICLE
María D Navarro-Hortal, Jose M Romero-Márquez, Pedro Muñoz-Ollero, Victoria Jiménez-Trigo, Adelaida Esteban-Muñoz, Kilian Tutusaus, Francesca Giampieri, Maurizio Battino, Cristina Sánchez-González, Lorenzo Rivas-García, Juan Llopis, Tamara Y Forbes-Hernández, José L Quiles
Alzheimer's is a chronic degenerative disease of the central nervous system considered the leading cause of dementia in the world. It is characterized by two etiopathological events related to oxidative stress: the aggregation of β-amyloid peptide and the formation of neurofibrillary tangles of hyperphosphorylated Tau protein in the brain. The incidence of this disease increases with age and has been associated with inadequate lifestyles. Some natural compounds have been shown to improve the hallmarks of the disease...
October 11, 2022: Food & Function
https://read.qxmd.com/read/36127723/interpretable-deep-learning-of-myelin-histopathology-in-age-related-cognitive-impairment
#17
JOURNAL ARTICLE
Andrew T McKenzie, Gabriel A Marx, Daniel Koenigsberg, Mary Sawyer, Megan A Iida, Jamie M Walker, Timothy E Richardson, Gabriele Campanella, Johannes Attems, Ann C McKee, Thor D Stein, Thomas J Fuchs, Charles L White, Kurt Farrell, John F Crary
Age-related cognitive impairment is multifactorial, with numerous underlying and frequently co-morbid pathological correlates. Amyloid beta (Aβ) plays a major role in Alzheimer's type age-related cognitive impairment, in addition to other etiopathologies such as Aβ-independent hyperphosphorylated tau, cerebrovascular disease, and myelin damage, which also warrant further investigation. Classical methods, even in the setting of the gold standard of postmortem brain assessment, involve semi-quantitative ordinal staging systems that often correlate poorly with clinical outcomes, due to imperfect cognitive measurements and preconceived notions regarding the neuropathologic features that should be chosen for study...
September 21, 2022: Acta Neuropathologica Communications
https://read.qxmd.com/read/35649654/imaging-neuroinflammation-in-neurodegenerative-disorders
#18
REVIEW
Joseph C Masdeu, Belen Pascual, Masahiro Fujita
Neuroinflammation plays a major role in the etiopathology of neurodegenerative diseases, including Alzheimer and Parkinson diseases, frontotemporal lobar degeneration, and amyotrophic lateral sclerosis. In vivo monitoring of neuroinflammation using PET is critical to understand this process, and data are accumulating in this regard, thus a review is useful. From PubMed, we retrieved publications using any of the available PET tracers to image neuroinflammation in humans as well as selected articles dealing with experimental animal models or the chemistry of currently used or potential radiotracers...
June 2022: Journal of Nuclear Medicine
https://read.qxmd.com/read/35523375/vitamin-b12-as-a-cholinergic-system-modulator-and-blood-brain-barrier-integrity-restorer-in-alzheimer-s-disease
#19
JOURNAL ARTICLE
Nesrine S El-Mezayen, Rehab A Abd El Moneim, Safaa H El-Rewini
So far, the cholinergic hypothesis of Alzheimer's disease (AD) remains the fundamental explanation for the complex etiopathology of AD. However, therapeutics raising synaptic acetylcholine (Ach) or having cholinergic receptors agonistic activity had shown limited clinical efficacy, possibly, due to lacking capability to aggregate cholinergic receptors within the degenerated cholinergic neurons. Vitamin-B12 (B12) is an epigenetic modifier. It has a specific CNS transport system via the cubam receptors. The later enclose a cholinergic aggregator; agrin protein, suggesting that B12 administration may cause cholinergic receptors aggregation...
July 1, 2022: European Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/35471949/second-sphere-interactions-in-amyloidogenic-diseases
#20
REVIEW
Madhuparna Roy, Arnab Kumar Nath, Ishita Pal, Somdatta Ghosh Dey
Amyloids are protein aggregates bearing a highly ordered cross β structural motif, which may be functional but are mostly pathogenic. Their formation, deposition in tissues and consequent organ dysfunction is the central event in amyloidogenic diseases. Such protein aggregation may be brought about by conformational changes, and much attention has been directed toward factors like metal binding, post-translational modifications, mutations of protein etc., which eventually affect the reactivity and cytotoxicity of the associated proteins...
July 27, 2022: Chemical Reviews
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