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Epidemiology and aging

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https://www.readbyqxmd.com/read/29050015/incidence-prevalence-and-global-distribution-of-root-caries
#1
Martina Hayes, Francis Burke, Patrick Finbarr Allen
High quality epidemiological data are essential for both the development of national oral health policies and cost-effective targeting of resources. Unfortunately, a high level of clinical heterogeneity between studies in this area makes it difficult, and inappropriate, to try to produce any definitive figures on the global prevalence or incidence of root caries. Published studies have reported wide ranges for the prevalence of root caries (25-100%) and the mean Root Caries Index (9.7-38.7). The reported range for annual root caries incidence is also wide, from 10...
2017: Monographs in Oral Science
https://www.readbyqxmd.com/read/29049858/adolescents-and-young-adults-with-brain-tumors-in-the-context-of-molecular-advances-in-neuro-oncology
#2
REVIEW
Michal Zapotocky, Vijay Ramaswamy, Alvaro Lassaletta, Eric Bouffet
Adolescents and young adults (AYA) comprise a specific group of oncology patients with a distinct biological and epidemiological spectrum of central nervous system neoplasms. It has been well documented that they differ clinically, especially in relation to prognosis and chemotherapy tolerance; however, the underlying reasons for this are unclear. Recent advances in the genomics of both childhood and adult brain tumors have provided new explanations and insights into the previously described age-dependent heterogeneity...
October 19, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29049464/clustering-of-neuropsychiatric-disease-in-first-degree-and-second-degree-relatives-of-patients-with-amyotrophic-lateral-sclerosis
#3
Margaret O'Brien, Tom Burke, Mark Heverin, Alice Vajda, Russell McLaughlin, John Gibbons, Susan Byrne, Marta Pinto-Grau, Marwa Elamin, Niall Pender, Orla Hardiman
Importance: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative condition primarily involving the motor system. There is increasing epidemiologic evidence of an association between ALS and a wider spectrum of neurodegenerative and neuropsychiatric disorders among family members, including schizophrenia and psychotic illness and suicidal behavior. Objective: To examine the frequency and range of neuropsychiatric conditions that occur within individual first-degree and second-degree relatives of patients with ALS...
October 16, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29049463/prevalence-of-age-related-macular-degeneration-in-australia-the-australian-national-eye-health-survey
#4
Stuart Keel, Jing Xie, Joshua Foreman, Peter van Wijngaarden, Hugh R Taylor, Mohamed Dirani
Importance: Age-related macular degeneration (AMD) is a leading cause of irreversible blindness among the elderly population globally. Currently, knowledge of the epidemiology of AMD in Australia remains scarce because of a paucity of recent population-based data. Objective: To examine the prevalence of AMD in Australia. Design, Setting, and Participants: In this population-based, cross-sectional survey performed from March 11, 2015, to April 18, 2016, a sample of 3098 nonindigenous Australians 50 years and older and 1738 indigenous Australians 40 years and older from 30 geographic areas across Australia were examined...
October 12, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29048948/the-spectrum-of-sickle-hemoglobin-related-nephropathy-from-sickle-cell-disease-to-sickle-trait
#5
Rakhi P Naik, Vimal K Derebail
Renal dysfunction is among the most common complication of sickle cell disease (SCD), from hyposthenuria in children to progression to overt chronic kidney disease (CKD) in young adults. Emerging evidence now suggests that sickle hemoglobin-related nephropathy extends to individuals with sickle cell trait (SCT). Areas covered: This review will highlight the pathophysiology, epidemiology, and management recommendations for sickle nephropathy in both SCD and SCT. In addition, it will focus on the major demographic and genetic modifiers of renal disease in sickling hemoglobinopathies...
October 19, 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/29047424/drug-resistant-tuberculosis-among-children-china-2006-2015
#6
Ning-Ning Tao, Xiao-Chun He, Xian-Xin Zhang, Yao Liu, Chun-Bao Yu, Huai-Chen Li
Microbial drug resistance has become a major public health concern worldwide. To acquire epidemiologic data on drug-resistant tuberculosis (DR TB) among children, a major cause of illness and death for this population, we conducted a retrospective study of 2006-2015 data from 36 TB prevention and control institutions in Shandong Province, China. A total of 14,223 new TB cases, among which children (<18 years of age) accounted for only 5.5%, were caused by culture-confirmed Mycobacterium tuberculosis. Among children with TB, 18...
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29047122/the-presence-of-philadelphia-chromosome-does-not-confer-poor-prognosis-in-adult-pre-b-acute-lymphoblastic-leukaemia-in-the-tyrosine-kinase-inhibitor-era-a-surveillance-epidemiology-and-end-results-database-analysis
#7
Igwe J Igwe, Dongyun Yang, Akil Merchant, Noah Merin, George Yaghmour, Kevin Kelly, Giridharan Ramsingh
The BCR-ABL1 fusion gene is caused by a translocation between chromosomes 9 and 22, resulting in an abnormal chromosome 22 (Philadelphia chromosome; Ph). Prior to the introduction of tyrosine kinase inhibitors (TKI), the presence of BCR-ABL1 conferred a poor prognosis in patients with acute lymphoblastic leukaemia (ALL). We compared the survival of Ph+ and Ph-ALL during the period when TKIs were universally available in the US for Ph+ALL, using a Surveillance, Epidemiology, and End Results (SEER) Database analysis...
October 18, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29047020/rotavirus-epidemiology-and-vaccine-demand-considering-bangladesh-chapter-through-the-book-of-global-disease-burden
#8
REVIEW
Abdullah Mahmud-Al-Rafat, Abdul Muktadir, Hasneen Muktadir, Mahbubul Karim, Arpan Maheshwari, Mohammad Mainul Ahasan
BACKGROUND: Rotavirus is the major cause of gastroenteritis in children throughout the world. Every year, a large number of children aged < 5 years die from rotavirus-related diarrhoeal diseases. Though these infections are vaccine-preventable, the vast majority of children in low-income countries suffer from the infection. The situation leads to severe economic loss and constitutes a major public health problem. METHODS: We searched electronic databases including PubMed and Google scholar using the following words: "features of rotavirus," "epidemiology of rotavirus," "rotavirus serotypes," "rotavirus in Bangladesh," "disease burden of rotavirus," "rotavirus vaccine," "low efficacy of rotavirus vaccine," "inactivated rotavirus vaccine"...
October 19, 2017: Infection
https://www.readbyqxmd.com/read/29047004/age-patterns-in-risk-taking-across-the-world
#9
Natasha Duell, Laurence Steinberg, Grace Icenogle, Jason Chein, Nandita Chaudhary, Laura Di Giunta, Kenneth A Dodge, Kostas A Fanti, Jennifer E Lansford, Paul Oburu, Concetta Pastorelli, Ann T Skinner, Emma Sorbring, Sombat Tapanya, Liliana Maria Uribe Tirado, Liane Peña Alampay, Suha M Al-Hassan, Hanan M S Takash, Dario Bacchini, Lei Chang
Epidemiological data indicate that risk behaviors are among the leading causes of adolescent morbidity and mortality worldwide. Consistent with this, laboratory-based studies of age differences in risk behavior allude to a peak in adolescence, suggesting that adolescents demonstrate a heightened propensity, or inherent inclination, to take risks. Unlike epidemiological reports, studies of risk taking propensity have been limited to Western samples, leaving questions about the extent to which heightened risk taking propensity is an inherent or culturally constructed aspect of adolescence...
October 19, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/29046744/clinical-and-epidemiological-characteristics-of-patients-with-acute-drug-intoxication-admitted-to-icu
#10
Jose Orsini, Nanda Din, Ershad Elahi, Anthony Gomez, Salil Rajayer, Ryan Malik, Elie Jean
Background: Drug overdose continues to be the most common cause of acute poisoning worldwide. There has been a substantial increase in drug overdose incidence and prevalence over the past decade, probably as a result of the emergence of new synthetic designer drugs. The purpose of this study is to describe the clinical and epidemiological characteristics of patients with acute drug intoxication admitted to the Intensive Care Unit (ICU). Methods: A single center, prospective, observational study was conducted among all adult patients with clinical signs suggestive of acute drug intoxication admitted from the Emergency Department (ED) to ICU during a 6-month period (September to March)...
October 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29046022/-prevalence-of-allergic-rhinitis-and-its-symptoms-in-the-school-children-population-of-cuernavaca-morelos-mexico
#11
Eleazar Mancilla-Hernández, Evaristo Víctor Manuel González-Solórzano, Miguel Alejandro Medina-Ávalos, Raúl Humberto Barnica-Alvarado
BACKGROUND: Studies on allergic rhinitis prevalence have found significant variations in their results, even in closely-living populations. OBJECTIVE: To determine and compare the prevalence of allergic rhinitis and its symptoms in schoolchildren from Cuernavaca, Morelos, Mexico. METHODS: Cross-sectional, descriptive study on the prevalence of allergic rhinitis diagnosis and symptoms, where the "Diagnostic questionnaire for epidemiological studies" was used between June and December 2015 in pre-school and primary and secondary school population, after authorization was granted by parents and school authorities...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29045712/hospice-utilization-in-patients-with-malignant-gliomas
#12
Deborah Forst, Eric Adams, Ryan Nipp, Allison Martin, Areej El-Jawahri, Ayal Aizer, Justin T Jordan
BACKGROUND: Despite recommendations from professional organizations supporting early hospice enrollment for patients with cancer, little research exists regarding end-of-life (EOL) practices for patients with malignant gliomas (MG). We evaluated rates and correlates of hospice enrollment and hospice length-of-stay (LOS) among patients with MG. METHODS: Using the Surveillance, Epidemiology and End Results (SEER)-Medicare linked database, we identified adult patients who were diagnosed with MG from January 1, 2002 to December 31, 2011 and who died before December 31, 2012...
October 16, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29045309/cardiovascular-mortality-among-76%C3%A2-864-survivors-of-childhood-cancers-in-the-united-states-a-report-from-the-surveillance-epidemiology-and-end-results-program
#13
Saurav Uppal, Sadeer G Al-Kindi, Guilherme H Oliveira
BACKGROUND: Childhood cancer survivors have increased risk for cardiovascular disease. We sought to describe the trends of cardiovascular mortality (CVM) among survivors of childhood cancers in the United States. METHODS: We used the Surveillance, Epidemiology, and End-Results 18 database to identify all children who were diagnosed with childhood cancers between 1973 and 2013. We describe the incidence of CVM in four eras (era 1: 1973-1982, era 2: 1983-1992, era 3: 1993-2002, and era 4: 2003-2013)...
October 16, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29044854/targeted-proteomic-analysis-of-habitual-coffee-consumption
#14
Marilyn C Cornelis, Stefan Gustafsson, Johan Ärnlöv, Sölve Elmståhl, Stefan Söderberg, Johan Sundström, Karl Michaëlsson, Lars Lind, Erik Ingelsson
BACKGROUND: Coffee drinking has been implicated in mortality and a variety of diseases but potential mechanisms underlying these associations are unclear. Large-scale systems epidemiological approaches may offer novel insights to mechanisms underlying associations of coffee with health. OBJECTIVE: We performed an analysis of known and novel protein markers linked to cardiovascular disease and their association with habitual coffee intake in the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS, n=816) and followed-up top proteins in the Uppsala Longitudinal Study of Adult Men (ULSAM, n=635) and EpiHealth (n=2418)...
October 16, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29044591/duodenal-localization-is-a-negative-predictor-of-survival-after-small-bowel-adenocarcinoma-resection-a-population-based-propensity-score-matched-analysis
#15
Alexander Wilhelm, Christian Galata, Ulrich Beutner, Bruno M Schmied, Rene Warschkow, Thomas Steffen, Walter Brunner, Stefan Post, Lukas Marti
BACKGROUND AND OBJECTIVES: This study assessed the influence of tumor localization of small bowel adenocarcinoma on survival after surgical resection. METHODS: Patients with resected small bowel adenocarcinoma, ACJJ stage I-III, were identified from the Surveillance, Epidemiology, and End Results database from 2004 to 2013. The impact of tumor localization on overall and cancer-specific survival was assessed using Cox proportional hazard regression models with and without risk-adjustment and propensity score methods...
October 16, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29044435/impact-of-clinical-parameters-in-the-intrahost-evolution-of-hiv-1-subtype-b-in-pediatric-patients-a-machine-learning-approach
#16
Patricia Rojas Sánchez, Alberto Cobos, Marisa Navaro, José Tomas Ramos, Israel Pagán, África Holguín
Determining the factors modulating the genetic diversity of HIV-1 populations is essential to understand viral evolution. This study analyzes the relative importance of clinical factors in the intrahost HIV-1 subtype B (HIV-1B) evolution and in the fixation of drug resistance mutations (DRM) during longitudinal pediatric HIV-1 infection. We recovered 162 partial HIV-1B pol sequences (from 3 to 24 per patient) from 24 perinatally infected patients from the Madrid Cohort of HIV-1 infected children and adolescents in a time interval ranging from 2...
October 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29044357/oral-health-sentinel-based-surveillance-a-pilot-study-on-dentinal-hypersensitivity-pain
#17
F Guerra, D Corridore, F Cocco, M Arrica, F Rinaldo, M Mazur, C Sanavia, G M Nardi, G Campus, L Ottolenghi
Aim of the study is to assess the development of a structured sentinel system for oral health data collection at national level. Furthermore, this pilot study aims to investigate the prevalence data on dentinal sensitivity pain collected through a nationwide network of epidemiological sentinels (dental hygienists). Each sentinel was given a specific number of examinees and periodicity of data collection. Overall, 116 adults were recruited from 19 Regions, 42,24% male and 57,76% female, with a mean age of 26...
September 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/29044356/-active-surveillance-evaluation-of-anti-hpv-vaccine-adverse-events-in-umbria-region
#18
V Gianfredi, M C Paoloni, M Villarini, M Moretti
AIMS: The study is a part of the "Active surveillance of adverse events following HPV vaccination" project conducted in order to actively register all common adverse events in girls 9-26 years after anti-HPV vaccination. METHODS: It is a multicenter cohort study which included 12 Regions and 87 local health authorities, coordinated by the National Centre for Epidemiology, Surveillance and Health Promotion (CNESPS) ISS. We included all adolescents, 12 years old, actively contacted for HPV vaccination, as well as all women aged 9-26 years who recived, in the period under review, the same vaccination at the local health authorities in Spoleto...
September 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/29044062/changing-epidemiology-of-neovascular-glaucoma-from-2002-to-2012-at-king-khaled-eye-specialist-hospital-saudi-arabia
#19
Abdullah Al-Bahlal, Rajiv Khandekar, Khalid Al Rubaie, Tariq Alzahim, Deepak P Edward, Igor Kozak
PURPOSE: The aim is to present the incidence and determinants of neovascular glaucoma (NVG) in Saudi Arabia. METHODS: A retrospective review of NVG cases (2002-2012) was included to estimate the incidence. The determinants included gender, age, comorbidities, lens status, type of NVG, and visual acuity on presentation. The impact of antiangiogenic therapy on NVG incidence was studied. RESULTS: We studied 597 eyes with NVG. The incidence was 6...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29044037/-review-of-epidemiology-of-fractures-in-the-icelandic-heart-association-cohort
#20
Gunnar Sigurdsson, Kristin Siggeirsdottir, Brynjolfur Y Jonsson, Brynjolfur Morgensen, Elías F Gudmundsson, Thor Aspelund, Vilmundur Gudnason
IIn recent years, scientific papers have been published in Osteoporosis International on the epidemiology of fractures in Iceland based on the Icelandic Heart Association cohort. We report the main results with emphasis on the major osteoporotic fractures (MOF), distal forearm, upper arm, clinical vertebral and hip. Those four types of fractures have been reported to cause about 90% of the total burden of all osteoporotic fractures. The incidence of those four fractures in the Icelandic Heart Association cohort have been used as the basis for the international fracture risk calculator "FRAX "in Iceland...
October 2017: Læknablađiđ
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