keyword
MENU ▼
Read by QxMD icon Read
search

mTBI

keyword
https://www.readbyqxmd.com/read/28089558/startle-suppression-after-mild-traumatic-brain-injury-is-associated-with-an-increase-in-pro-inflammatory-cytokines-reactive-gliosis-and-neuronal-loss-in-the-caudal-pontine-reticular-nucleus
#1
Swamini P Sinha, Pelin Avcu, Kevin M Spiegler, Sreeya Komaravolu, Kevin Kim, Tara Cominski, Richard J Servatius, Kevin C H Pang
Mild traumatic brain injury (mTBI) can produce somatic symptoms such as headache, dizziness, fatigue, sleep disturbances and sensorimotor dysfunction. Sensorimotor function can be measured by tests such as the acoustic startle reflex (ASR), an evolutionarily conserved defensive response to a brief yet sharp acoustic stimulus. mTBI produces a long-lasting suppression of ASR in rodents and humans; however, the mechanism of this suppression is unknown. The present study examined whether inflammatory processes in the brainstem (particularly the caudal pontine reticular nucleus, PnC) could account for the suppression of ASR after mTBI, because the PnC is an essential nucleus of the ASR circuit...
January 9, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28072842/fractal-analysis-of-brain-blood-oxygenation-level-dependent-bold-signals-from-children-with-mild-traumatic-brain-injury-mtbi
#2
Olga Dona, Michael D Noseworthy, Carol DeMatteo, John F Connolly
BACKGROUND: Conventional imaging techniques are unable to detect abnormalities in the brain following mild traumatic brain injury (mTBI). Yet patients with mTBI typically show delayed response on neuropsychological evaluation. Because fractal geometry represents complexity, we explored its utility in measuring temporal fluctuations of brain resting state blood oxygen level dependent (rs-BOLD) signal. We hypothesized that there could be a detectable difference in rs-BOLD signal complexity between healthy subjects and mTBI patients based on previous studies that associated reduction in signal complexity with disease...
2017: PloS One
https://www.readbyqxmd.com/read/28060056/military-civilian-collaborations-for-mtbi-rehabilitation-research-in-an-active-duty-population-lessons-learned-from-the-assessment-of-military-multitasking-performance-project
#3
Karen L McCulloch, Amy S Cecchini, Mary V Radomski, Matthew R Scherer, Laurel Smith, Caroline Cleveland, Henry P McMillan, Leslie F Davidson, Margaret M Weightman
This article describes lessons learned in the planning, development, and administration of a collaborative military-civilian research project, the Assessment of Military Multitasking Performance, which was designed to address a gap in clinical assessment for active duty service members with mild traumatic brain injury who wish to return to active duty. Our team worked over the course of multiple years to develop an assessment for military therapists to address this need. Insights gained through trial and error are shared to provide guidance for civilian researchers who may wish to collaborate with active duty researchers...
January 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28056045/further-development-of-the-assessment-of-military-multitasking-performance-iterative-reliability-testing
#4
Margaret M Weightman, Karen L McCulloch, Mary V Radomski, Marsha Finkelstein, Amy S Cecchini, Leslie F Davidson, Kristin J Heaton, Laurel B Smith, Matthew R Scherer
The Assessment of Military Multitasking Performance (AMMP) is a battery of functional dual-tasks and multitasks based on military activities that target known sensorimotor, cognitive, and exertional vulnerabilities after concussion/mild traumatic brain injury (mTBI). The AMMP was developed to help address known limitations in post concussive return to duty assessment and decision making. Once validated, the AMMP is intended for use in combination with other metrics to inform duty-readiness decisions in Active Duty Service Members following concussion...
2017: PloS One
https://www.readbyqxmd.com/read/28055267/microstructural-changes-in-the-thalamus-after-mild-traumatic-brain-injury-a-longitudinal-diffusion-and-mean-kurtosis-tensor-mri-study
#5
Erhard Trillingsgaard Næss-Schmidt, Jakob Udby Blicher, Simon Fristed Eskildsen, Anna Tietze, Brian Hansen, Peter William Stubbs, Sune Jespersen, Leif Østergaard, Jørgen Feldbæk Nielsen
PRIMARY OBJECTIVE: The primary aim of this study was to assess microstructural changes in the thalamus, hippocampus and corpus callosum with a fast mean kurtosis tensor (MKT) technique, in the acute and sub-acute phase after mTBI. It was hypothesized that MKT would differ between baseline and follow-up in patients. The secondary aim was to relate diffusion measures to symptoms of mTBI. RESEARCH DESIGN: A longitudinal case-control study. METHODS AND PROCEDURES: Twenty-seven patients with mTBI and 27 age- and gender-matched healthy controls were enrolled in the study...
January 5, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28045562/parasympathetic-baroreflexes-and-heart-rate-variability-during-acute-stage-of-sport-concussion-recovery
#6
Scott Bishop, Ryan Dech, Taylor Baker, Matthew Butz, Kaishan Aravinthan, J Patrick Neary
PRIMARY OBJECTIVE: To assess and compare the parasympathetic state of individuals in healthy vs concussion groups, by measuring cardiovascular metrics under resting and baroreflex conditions using a squat-stand manoeuvre. RESEARCH DESIGN: This was a retrospective mixed-method study, with participants who sustained a medically diagnosed sport concussion (n = 12), being tested within 72-hours post-injury. METHODS AND PROCEDURES: Participant's heart rate (Electrocardiogram, ECG) and blood pressure (finger plethysmography) data was collected during rest and during 10-second squat-stands (10SS, 0...
January 3, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28042930/three-versus-seven-days-to-return-to-work-after-mild-traumatic-brain-injury-a-randomised-parallel-group-trial-with-neuropsychological-assessment
#7
Aline M Studerus-Germann, Doortje C Engel, Martin N Stienen, Dieter von Ow, Gerhard Hildebrandt, Oliver P Gautschi
Although most patients with a mild traumatic brain injury (mTBI) recover within days to weeks, some experience persistent physical, cognitive and emotional symptoms, often described as postconcussion syndrome (PCS). The optimal recovery time including return-to-work (RTW) after mTBI is unclear. In this single-centre parallel-group trial, patients assigned three days (3D-group) or seven days (7D-group) sick leave were compared with a comprehensive neuropsychological test battery including the Post Concussion Symptom Scale (PCSS) within one week, after three and twelve months post-injury...
January 2, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28039735/language-control-in-bilingual-adults-with-and-without-history-of-mild-traumatic-brain-injury
#8
Ileana Ratiu, Tamiko Azuma
Adults with a history of traumatic brain injury often show deficits in executive functioning (EF), including the ability to inhibit, switch, and attend to tasks. These abilities are critical for language processing in bilinguals. This study examined the effect of mild traumatic brain injury (mTBI) on EF and language processing in bilinguals using behavioral and eye-tracking measures. Twenty-two bilinguals with a history of mTBI and twenty healthy control bilinguals were administered executive function and language processing tasks...
December 28, 2016: Brain and Language
https://www.readbyqxmd.com/read/28038987/adaptive-reorganization-of-retinogeniculate-axon-terminals-in-dorsal-lateral-geniculate-nucleus-following-experimental-mild-traumatic-brain-injury
#9
Vishal C Patel, Christopher W D Jurgens, Thomas E Krahe, John T Povlishock
The pathologic process in traumatic brain injury marked by delayed axonal loss, known as diffuse axonal injury (DAI), leads to partial deafferentation of neurons downstream of injured axons. This process is linked to persistent visual dysfunction following mild traumatic brain injury (mTBI), however, examination of deafferentation in humans is impossible with current technology. To investigate potential reorganization in the visual system following mTBI, we utilized the central fluid percussion injury (cFPI) mouse model of mTBI...
December 28, 2016: Experimental Neurology
https://www.readbyqxmd.com/read/28032004/orbitofrontal-cortical-thinning-and-aggression-in-mild-traumatic-brain-injury-patients
#10
Daniel J Epstein, Margaret Legarreta, Elliot Bueler, Jace King, Erin McGlade, Deborah Yurgelun-Todd
INTRODUCTION: Although mild traumatic brain injury (mTBI) comprises 80% of all TBI, the morphological examination of the orbitofrontal cortex (OFC) in relation to clinical symptoms such as aggression, anxiety and depression in a strictly mTBI sample has never before been performed. OBJECTIVES: The primary objective of the study was to determine if mTBI patients would show morphological differences in the OFC and if the morphology of this region would relate to clinical symptoms...
December 2016: Brain and Behavior
https://www.readbyqxmd.com/read/28030563/the-involvement-of-pial-microvessels-in-leukocyte-invasion-after-mild-traumatic-brain-injury
#11
Joanna Szmydynger-Chodobska, Rongzi Shan, Nicole Thomasian, Adam Chodobski
The pathophysiological mechanisms underlying mild traumatic brain injury (mTBI) are not well understood, but likely involve neuroinflammation. Here the controlled cortical impact model of mTBI in rats was used to test this hypothesis. Mild TBI caused a rapid (within 6 h post-mTBI) upregulation of synthesis of TNF-α and IL-1β in the cerebral cortex and hippocampus, followed by an increase in production of neutrophil (CXCL1-3) and monocyte (CCL2) chemoattractants. While astrocytes were not a significant source of CXC chemokines, they highly expressed CCL2...
2016: PloS One
https://www.readbyqxmd.com/read/28018987/eeg-slow-waves-in-traumatic-brain-injury-convergent-findings-in-mouse-and-man
#12
Mo Modarres, Nicholas N Kuzma, Tracy Kretzmer, Allan I Pack, Miranda M Lim
OBJECTIVE: Evidence from previous studies suggests that greater sleep pressure, in the form of EEG-based slow waves, accumulates in specific brain regions that are more active during prior waking experience. We sought to quantify the number and coherence of EEG slow waves in subjects with mild traumatic brain injury (mTBI). METHODS: We developed a method to automatically detect individual slow waves in each EEG channel, and validated this method using simulated EEG data...
July 1, 2016: Neurobiology of Sleep and Circadian Rhythms
https://www.readbyqxmd.com/read/28007313/neuropsychological-alterations-and-neuroradiological-findings-in-patients-with-post-traumatic-concussion-results-of-a-pilot-study
#13
A Rădoi, M A Poca, V Cañas, J M Cevallos, L Membrado, M C Saavedra, M Vidal, F Martínez-Ricarte, J Sahuquillo
INTRODUCTION: Mild traumatic brain injury (mTBI) has traditionally been considered to cause no significant brain damage since symptoms spontaneously remit after a few days. However, this idea is facing increasing scrutiny. The purpose of this study is to demonstrate the presence of early cognitive alterations in a series of patients with mTBI and to link these findings to different markers of brain damage. METHODS: We conducted a prospective study of a consecutive series of patients with mTBI who were evaluated over a 12-month period...
December 19, 2016: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/28006976/contrasting-effects-of-posttraumatic-stress-disorder-and-mild-traumatic-brain-injury-on-the-whole-brain-resting-state-network-a-magnetoencephalography-study
#14
Jared Rowland, Jennifer Stapleton-Kotloski, Greg Alberto, Justin Rawley, Robert Kotloski, Katherine Taber, Dwayne Godwin
The aim of the current study was to evaluate alterations in whole-brain resting-state networks associated with posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI). Networks were constructed from locations of peak statistical power on an individual basis from magnetoencephalography (MEG) source series data by applying the weighted phase lag index and surrogate data thresholding procedures. Networks representing activity in the alpha bandwidth as well as wide band activity (DC-80 Hz) were created...
December 23, 2016: Brain Connectivity
https://www.readbyqxmd.com/read/28006970/phase-ii-clinical-trial-of-atorvastatin-in-mild-traumatic-brain-injury
#15
Claudia S Robertson, James J McCarthy, Emmy R Miller, Harvey Levin, Stephen R McCauley, Paul R Swank
Statins constitute a class of medications commonly used in the treatment of elevated cholesterol. However, in experimental studies statins also have other non-cholesterol mediated mechanisms of action, which may have neuroprotective effects. The purpose of this study was to determine if administration of atorvastatin for 7 days after injury would improve neurological recovery in patients with mild traumatic brain injury (mTBI). The hypothesis was that atorvastatin administration would reduce post-concussion symptoms and also that atorvastatin administration for one week post-injury would be safe...
December 22, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27998904/word-memory-test-performance-across-cognitive-domains-psychiatric-presentations-and-mild-traumatic-brain-injury
#16
Jared A Rowland, Holly M Miskey, Timothy W Brearly, Sarah L Martindale, Robert D Shura
OBJECTIVE: The current study addressed two aims: (i) determine how Word Memory Test (WMT) performance relates to test performance across numerous cognitive domains and (ii) evaluate how current psychiatric disorders or mild traumatic brain injury (mTBI) history affects performance on the WMT after excluding participants with poor symptom validity. METHOD: Participants were 235 Iraq and Afghanistan-era veterans (Mage = 35.5) who completed a comprehensive neuropsychological battery...
December 19, 2016: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/27996331/volumetric-and-morphometric-mri-findings-in-patients-with-mild-traumatic-brain-injury
#17
T Hellstrøm, L T Westlye, A Server, M Løvstad, C Brunborg, M J Lund, W Nordhøy, O A Andreassen, N Andelic
OBJECTIVE: This study compared cortical and sub-cortical volumes between patients with complicated (i.e. presence of intracranial abnormality on the day-of-injury CT) and uncomplicated (i.e. absence of intracranial abnormality) mild traumatic brain injury (MTBI) 4 weeks post-injury. The study hypothesized regionally decreased brain volumes and reduced cortical thickness in patients with complicated MTBIs compared with uncomplicated MTBI. METHODS: This study was part of a larger 2 years cohort study on MTBI...
2016: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27981032/high-angular-resolution-diffusion-weighted-imaging-in-mild-traumatic-brain-injury
#18
Mehrbod Mohammadian, Timo Roine, Jussi Hirvonen, Timo Kurki, Henna Ala-Seppälä, Janek Frantzén, Ari Katila, Anna Kyllönen, Henna-Riikka Maanpää, Jussi Posti, Riikka Takala, Jussi Tallus, Olli Tenovuo
We sought to investigate white matter abnormalities in mild traumatic brain injury (mTBI) using diffusion-weighted magnetic resonance imaging (DW-MRI). We applied a global approach based on tract-based spatial statistics skeleton as well as constrained spherical deconvolution tractography. DW-MRI was performed on 102 patients with mTBI within two months post-injury and 30 control subjects. A robust global approach considering only the voxels with a single-fiber configuration was used in addition to global analysis of the tract skeleton and probabilistic whole-brain tractography...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27936960/the-effects-of-mild-traumatic-brain-injury-on-postural-control
#19
Adriana M Degani, Maria M Santos, Charles T Leonard, Thomas F Rau, Sarjubhai A Patel, Sambit Mohapatra, Alessander Danna-Dos-Santos
PRIMARY OBJECTIVE: The purpose of this study was to investigate the effects of mild traumatic brain injury (mTBI) on multiple postural indices that characterize body sway behaviour. METHODS AND PROCEDURES: The body's centre of pressure (COP) displacement was recorded from 11 individuals with a history of mTBI (29.4 ± 6.7 years old) and 11 healthy controls (26.8 ± 3.7 years old) performing bipedal stance on a force platform for 120 seconds. Spatio-temporal (area, amplitude and mean velocity of the COP displacement) and frequency characteristics (frequency containing 80% of the power spectral density) of the body oscillation, as well as its dynamic characteristics (sample entropy estimate of the COP displacement) were extracted from COP signals...
December 12, 2016: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27936001/computerized-analysis-of-verbal-fluency-normative-data-and-the-effects-of-repeated-testing-simulated-malingering-and-traumatic-brain-injury
#20
David L Woods, John M Wyma, Timothy J Herron, E William Yund
In verbal fluency (VF) tests, subjects articulate words in a specified category during a short test period (typically 60 s). Verbal fluency tests are widely used to study language development and to evaluate memory retrieval in neuropsychiatric disorders. Performance is usually measured as the total number of correct words retrieved. Here, we describe the properties of a computerized VF (C-VF) test that tallies correct words and repetitions while providing additional lexical measures of word frequency, syllable count, and typicality...
2016: PloS One
keyword
keyword
2450
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"