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https://www.readbyqxmd.com/read/28529912/female-gonadal-hormone-effects-on-microglial-activation-and-functional-outcomes-in-a-mouse-model-of-moderate-traumatic-brain-injury
#1
Odera Umeano, Haichen Wang, Hana Dawson, Beilei Lei, Afoma Umeano, Dawn Kernagis, Michael L James
AIM: To address the hypothesis that young, gonad-intact female mice have improved long-term recovery associated with decreased neuroinflammation compared to male mice. METHODS: Eight to ten week-old male, female, and ovariectomized (OVX) mice underwent closed cranial impact. Gonad-intact female mice were injured only in estrus state. After injury, between group differences were assessed using complementary immunohistochemical staining for microglial cells at 1 h, mRNA polymerase chain reaction for inflammatory markers at 1 h after injury, Rotarod over days 1-7, and water maze on days 28-31 after injury...
May 4, 2017: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28527643/parental-knowledge-and-recall-of-concussion-discharge-instructions
#2
Danny George Thomas, Lia Bradley, Ashley Servi, Suzanne Reilly, Jennifer Niskala Apps, Michael McCrea, Thomas Hammeke
INTRODUCTION: Children increasingly are being seen in the emergency department for a concussion, or mild traumatic brain injury (mTBI). A key aim of the ED visit is to provide discharge advice that can help parents to identify an evolving neurosurgical crisis, facilitate recovery, and prevent reinjury. The present study examined parents' knowledge of symptoms and recall of discharge instructions after their adolescent's mTBI and the effect of supplementing written discharge instructions with verbal instruction and reinforcement...
May 17, 2017: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
https://www.readbyqxmd.com/read/28522089/sleep-stage-distribution-in-persons-with-mild-traumatic-brain-injury-a-polysomnographic-study-according-to-american-academy-of-sleep-medicine-standards
#3
Tatyana Mollayeva, Angela Colantonio, J David Cassidy, Lee Vernich, Rahim Moineddin, Colin M Shapiro
OBJECTIVE AND BACKGROUND: Sleep stage disruption in persons with mild traumatic brain injury (mTBI) has received little research attention. We examined deviations in sleep stage distribution in persons with mTBI relative to population age- and sex-specific normative data and the relationships between such deviations and brain injury-related, medical/psychiatric, and extrinsic factors. PATIENTS AND METHODS: We conducted a cross-sectional polysomnographic investigation in 40 participants diagnosed with mTBI (mean age 47...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28520675/the-role-of-cognitive-reserve-in-recovery-from-traumatic-brain-injury
#4
Kayla A Steward, Richard Kennedy, Thomas A Novack, Michael Crowe, Daniel C Marson, Kristen L Triebel
OBJECTIVE: To examine whether cognitive reserve (CR) attenuates the initial impact of traumatic brain injury (TBI) on cognitive performance (neural reserve) and results in faster cognitive recovery rates in the first year postinjury (neural compensation), and whether the advantage of CR differs on the basis of the severity of TBI. SETTING: Inpatient/outpatient clinics at an academic medical center. PARTICIPANTS: Adults with mild TBI (mTBI; n = 28), complicated mild TBI (cmTBI; n = 24), and moderate to severe TBI (msevTBI; n = 57), and demographically matched controls (n = 66)...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28520668/structural-connectivity-related-to-persistent-symptoms-after-mild-tbi-in-adolescents-and-response-to-aerobic-training-preliminary-investigation
#5
Weihong Yuan, Shari L Wade, Catherine Quatman-Yates, Jason A Hugentobler, Paul J Gubanich, Brad G Kurowski
OBJECTIVE: To quantify structural connectivity abnormalities in adolescents with mild traumatic brain injury (mTBI) and to investigate connectivity changes following aerobic training using graph theory and diffusion tensor imaging tractography. SETTING: Outpatient research setting. PARTICIPANTS: Twenty-two children (age: 15.83 ± 1.77 years, 10 females) with 4 to 16 weeks of persistent symptoms after mTBI and a matched healthy comparison group...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28520663/contributions-to-executive-dysfunction-in-operation-enduring-freedom-operation-iraqi-freedom-veterans-with-posttraumatic-stress-disorder-and-history-of-mild-traumatic-brain-injury
#6
Sarah M Jurick, Laura D Crocker, Mark Sanderson-Cimino, Amber V Keller, Liljana S Trenova, Briana L Boyd, Elizabeth W Twamley, Carie S Rodgers, Dawn M Schiehser, Robin L Aupperle, Amy J Jak
OBJECTIVE: Posttraumatic stress disorder (PTSD), history of mild traumatic brain injury (mTBI), and executive function (EF) difficulties are prevalent in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) Veterans. We evaluated the contributions of injury variables, lower-order cognitive component processes (processing speed/attention), and psychological symptoms to EF. PARTICIPANTS: OEF/OIF Veterans (N = 65) with PTSD and history of mTBI were administered neuropsychological tests of EF and self-report assessments of PTSD and depression...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28514188/the-invisibility-of-mild-traumatic-brain-injury-impaired-cognitive-performance-as-a-silent-symptom
#7
Leore R Heim, Miaad Badar, Shahaf Edut, Lital Rachmany, Renana Baratz, Ran Lin, Aviya Elpaz, Doaa Qubty, Lior Bikovski, Vardit Rubovitch, Shaul Schreiber, Chaim G Pick
The present study was designed to tackle two notorious features of mild Traumatic Brain Injury (mTBI) - heterogeneity and invisibility - by characterizing the full scope of mTBI symptoms. Mice were exposed to brain injuries of different intensities utilizing a weight-drop model (10, 30, 50, and 70g), and subsequently subjected to a comprehensive battery of behavioral tests at different time points, and immunohistochemical examination of cortical slices. While the physiological, neurological, emotional, and motor function of mTBI mice, i...
May 17, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28512443/transcranial-direct-current-stimulation-for-post-concussion-syndrome-study-protocol-for-a-randomized-crossover-trial
#8
Robson Luis Oliveira de Amorim, André Russowsky Brunoni, Mirian Akiko Furutani de Oliveira, Ana Luiza Costa Zaninotto, Marcia Mitie Nagumo, Vinícius Monteiro de Paula Guirado, Iuri Santana Neville, Gláucia Rosana Guerra Benute, Mara Cristina Souza de Lucia, Wellingson Silva Paiva, Almir Ferreira de Andrade, Manoel Jacobsen Teixeira
BACKGROUND: Mild traumatic brain injury (MTBI) represents 70-80% of all treated brain injuries. A considerable proportion of MTBI patients experience post-concussion symptoms for a prolonged period after MTBI, and these symptoms are diagnosed as persistent post-concussion syndrome (PPCS). PPCS is defined as a range of physical, cognitive, and emotional symptoms. However, memory and executive dysfunction seems to be one of the most debilitating symptoms. Recently, non-invasive brain stimulation has been studied as a potential treatment method for traumatic brain injury (TBI) patients...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28509819/cortical-and-physical-function-after-mild-traumatic-brain-injury
#9
Alia L Yasen, David R Howell, Li-Shan Chou, Angela M Pazzaglia, Anita D Christie
PURPOSE: The aim of this study was to prospectively examine the association between intracortical inhibition and functional recovery after mild traumatic brain injury (mTBI). METHODS: Twenty individuals with mTBI and 20 matched control participants were assessed using transcranial magnetic stimulation, the Attentional Network Test, and gait analysis. Hierarchical linear modeling was used to longitudinally examine potential differences between groups and relationships in the pattern of recovery in cortical silent period (CSP) duration, cognitive reaction time, and single- and dual-task walking speeds across five testing time points...
June 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28499856/measuring-soldier-performance-during-the-patrol-exertion-multitask-preliminary-validation-of-a-post-concussive-functional-return-to-duty-metric
#10
Matthew Scherer, Margaret M Weightman, Mary Vining Radomski, Laurel Smith, Marsha Finkelstein, Amy Cecchini, Kristin Jensen Heaton, Karen McCulloch
OBJECTIVE: To assess the discriminant validity of the Patrol-Exertion Multitask (PEMT), a novel, multi-domain, functional return-to-duty clinical assessment for Active Duty military personnel. DESIGN: Measurement development study SETTING: Non-clinical indoor testing facility, Fort Bragg NC PARTICIPANTS: 51 healthy control (HC) Service Members and 33 military personnel with persistent post-concussive symptoms receiving rehabilitation (mTBI) INTERVENTION: Not applicable MAIN OUTCOME MEASURES: Known-groups discriminant validity was evaluated by comparing performance on the PEMT in two groups of Active Duty SM, HC and personnel with mTBI residual symptoms...
May 9, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28495608/short-term-caloric-restriction-exerts-neuroprotective-effects-following-mild-traumatic-brain-injury-by-promoting-autophagy-and-inhibiting-astrocyte-activation
#11
Yuan Liu, Rong Wang, Zhiwei Zhao, Wen Dong, Xu Zhang, Xi Chen, Lina Ma
Cognitive deficits may occur after mild traumatic brain injury (mTBI), but effective treatment modalities are presently unavailable. Caloric restriction (CR) has beneficial effects on neurodegenerative diseases and brain injury. However, the underlying mechanisms have not yet been clearly defined. Therefore, the aim of the present study was to investigate the short-term effects of CR treatment on cognitive function in mice after mTBI. Forty-five 12-week-old C57/BL6 mice were subjected to closed-head mTBI using a weight drop device...
May 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28494496/sensitivity-to-binocular-disparity-is-reduced-by-mild-traumatic-brain-injury
#12
Gunnar Schmidtmann, Tatiana Ruiz, Alexandre Reynaud, Daniel P Spiegel, Maude Laguë-Beauvais, Robert F Hess, Reza Farivar
Purpose: The impairment of visual functions is one of the most common complaints following mild traumatic brain injury (mTBI). Traumatic brain injury-associated visual deficits include blurred vision, reading problems, and eye strain. In addition, previous studies have found evidence that TBI can diminish early cortical visual processing, particularly for second-order stimuli. We investigated whether cortical processing of binocular disparity is also affected by mTBI. Methods: In order to investigate the influence of mTBI on global stereopsis, we measured the quick Disparity Sensitivity Function (qDSF) in 22 patients with mTBI...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28489698/epidemiology-of-isolated-versus-nonisolated-mild-traumatic-brain-injury-treated-in-emergency-departments-in-the-united-states-2006-2012-sociodemographic-characteristics
#13
Carol Cancelliere, Victor G Coronado, Christopher A Taylor, Likang Xu
OBJECTIVES: To describe the frequencies and rates of mild traumatic brain injury (mTBI) emergency department (ED) visits, analyze the trend across the years, and compare sociodemographic characteristics of visits by mTBI type (ie, mTBI as the only injury, or present along with other injuries). DESIGN: Population-based descriptive study using data from the Nationwide Emergency Department Sample (2006-2012). METHODS: Joinpoint regression was used to calculate the average annual percent changes of mTBI incidence rates...
November 8, 2016: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28489416/concordance-validity-of-pvts-in-a-sample-of-veterans-referred-for-mild-tbi
#14
Adam Zimmer, Daniel Heyanka, Zoe Proctor-Weber
Concordance validity of commonly used performance validity tests (PVTs) was assessed in a sample of Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn (OEF/OIF/OND) veterans referred to an mTBI screening clinic in a south-eastern Veterans Affairs hospital. Veteran service members (total n = 184) completed the Rey-15, Repeatable Battery of the Assessment for Neuropsychological Status Effort Index (RBANS EI), and Reliable Digit Span (RDS) from the Wechsler Intelligence Scales. Kappa coefficients and percentage of agreement were established to determine the level of concordance between the three measures...
May 10, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28484418/blast-exposure-white-matter-integrity-and-cognitive-function-in-iraq-and-afghanistan-combat-veterans
#15
Iliyan Ivanov, Corey Fernandez, Effie M Mitsis, Dara L Dickstein, Edmund Wong, Cheuk Y Tang, Jessie Simantov, Charlene Bang, Erin Moshier, Mary Sano, Gregory A Elder, Erin A Hazlett
The long-term effects of blast exposure are a major health concern for combat veterans returning from the recent conflicts in Iraq and Afghanistan. We used an optimized diffusion tensor imaging tractography algorithm to assess white matter (WM) fractional anisotropy (FA) in blast-exposed Iraq and Afghanistan veterans (n = 40) scanned on average 3.7 years after deployment/trauma exposure. Veterans diagnosed with a blast-related mild traumatic brain injury (mTBI) were compared to combat veterans with blast exposure but no TBI diagnosis...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28483653/mental-health-does-not-moderate-compensatory-cognitive-training-efficacy-for-veterans-with-a-history-of-mild-traumatic-brain-injury
#16
Kathleen F Pagulayan, Maya O'Neil, Rhonda M Williams, Aaron P Turner, Shahrokh Golshan, Mai S Roost, Benjamin Laman-Maharg, Marilyn Huckans, Daniel Storzbach, Elizabeth W Twamley
OBJECTIVE: To examine the potential moderating effects of mental health symptoms on the efficacy of Compensatory Cognitive Training (CCT) for Operation Enduring Freedom (OEF)/Operation Iraqi Freedom (OIF)/Operation New Dawn (OND) Veterans with a history of mild traumatic brain injury (mTBI). DESIGN: Secondary analysis of a randomized controlled trial of CCT. Posttraumatic stress disorder (PTSD), depression, and substance dependence symptom severity were examined as potential moderators of CCT efficacy for subjective cognitive complaints, use of cognitive strategies, and objective neurocognitive performance...
May 5, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28482747/three-year-trends-in-vha-utilization-and-costs-following-traumatic-brain-injury-screening-among-veterans-with-mild-traumatic-brain-injury
#17
Brent Taylor, Emily Hagel Campbell, Sean Nugent, Douglas Bidelspach, Shannon Kehle-Forbes, Joel Scholten, Kevin Stroupe, Nina Sayer
Examination of trends in Veterans Health Administration (VHA) healthcare utilization and costs among veterans with mild Traumatic Brain Injury (TBI) is needed to inform policy, resource allocation and treatment planning. The objective of this study was to assess the patterns of VHA healthcare utilization and costs in the three years following TBI screening among veterans with mild TBI compared with veterans without TBI. A retrospective cohort study of veterans who underwent TBI screening in fiscal year 2010 was conducted...
May 8, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28481634/outpatient-follow-up-after-mild-traumatic-brain-injury-results-of-the-upfront-study
#18
M E de Koning, M E Scheenen, H J van der Horn, G Hageman, G Roks, T Yilmaz, J M Spikman, J van der Naalt
OBJECTIVE: To investigate outpatient follow-up after mild traumatic brain injury (mTBI) by various medical specialists, for both hospitalized and non-hospitalized patients, and to study guideline adherence regarding hospital admission. METHODS: Patients (n = 1151) with mTBI recruited from the emergency department received questionnaires 2 weeks (n = 879), 3 months (n = 780) and 6 months (n = 668) after injury comprising outpatient follow-up by various health care providers, and outcome defined by the Glasgow Outcome Scale Extended (GOS-E) after 6 months...
May 8, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28479568/portable-qeeg-and-hd-tcs-device-for-point-of-injury-traumatic-brain-injury-diagnostics
#19
Frode Strisland, Jon Vedum, Anders Liverud, Steffen Dalgard, Tomas Brødreskift, Bruno Albert, Alexandre Noyvirt, Rossitza Setchi, Karl Vene, Henrik Herranen, Maarjus Kirs, Andrea Antal, Klaus Schellhorn, Haldor Sjaaheim
Mild Traumatic Brain Injury (mTBI) can cause prolonged or permanent injuries if left undetected and ignored. It is therefore of great interest to lower the threshold for diagnosis of individuals with mTBI injury. We report on the development of a prototype of a portable quantified EEG (qEEG) system intended for in-the-field mTBI diagnostics. The 32-electrode system is fully battery driven, is interfaced with a control unit being part of a telemedicine care system. Electrode montage is a central problem effectively challenging measurements outside clinical environments...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28474982/posttraumatic-epilepsy-long-term-follow-up-of-children-with-mild-traumatic-brain-injury
#20
Amit Keret, Odeya Bennett-Back, Guy Rosenthal, Tal Gilboa, Moatasim Shweiki, Yigal Shoshan, Mony Benifla
OBJECTIVE Posttraumatic epilepsy (PTE) is a known complication of traumatic brain injury (TBI). The true incidence of PTE in children is still uncertain, because most research has been based primarily on adults. This study aimed to determine the true incidence of PTE in a pediatric population with mild TBI (MTBI) and to identify risk factors for the development of epileptic events. METHODS Data were collected from electronic medical records of children 0-17 years of age, who were admitted to a single medical center between 2007 and 2009 with a diagnosis of MTBI...
May 5, 2017: Journal of Neurosurgery. Pediatrics
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