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https://www.readbyqxmd.com/read/29321373/the-current-state-of-biomarkers-of-mild-traumatic-brain-injury
#1
REVIEW
Han Jun Kim, Jack W Tsao, Ansley Grimes Stanfill
Mild traumatic brain injury (mTBI) is a common occurrence, with over 3 million cases reported every year in the United States. While research into the underlying pathophysiology is ongoing, there is an urgent need for better clinical guidelines that allow more consistent diagnosis of mTBI and ensure safe return-to-play timelines for athletes, nonathletes, and military personnel. The development of a suite of biomarkers that indicate the pathogenicity of mTBI could lead to clinically useful tools for establishing both diagnosis and prognosis...
January 11, 2018: JCI Insight
https://www.readbyqxmd.com/read/29316843/diagnosis-threat-and-underperformance-the-threat-must-be-relevant-and-implicit
#2
Megan Fresson, Benoit Dardenne, Thierry Meulemans
INTRODUCTION: The diagnosis threat (DT) phenomenon shows that, in some cases, reminding people with mild traumatic brain injury (mTBI) about their past neurological history diminishes subsequent cognitive performance. The aim of the present study was to investigate the role of personal relevance (i.e., domain identification) and type of threat (i.e., implicit vs. explicit) as moderating variables. We investigated intrusive thoughts as a potential mediator. METHOD: Control (non-mTBI) and mTBI participants were recruited and completed a domain identification questionnaire...
January 10, 2018: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/29303438/prospective-randomized-blinded-and-placebo-controlled-study-of-cerebrolysin-dose-response-effects-on-long-term-functional-outcomes-in-a-rat-model-of-mild-traumatic-brain-injury
#3
Yanlu Zhang, Michael Chopp, Zheng Gang Zhang, Yi Zhang, Li Zhang, Mei Lu, Talan Zhang, Stefan Winter, Hemma Brandstätter, Asim Mahmood, Ye Xiong
OBJECTIVE Cerebrolysin is a neuropeptide preparation that mimics the properties of neurotrophic factors and has had beneficial effects in the treatment of neurodegenerative diseases, stroke, and traumatic brain injury (TBI). To further evaluate treatment schemes, the authors assessed the dose-response of Cerebrolysin on functional improvement in a rat model of mild TBI (mTBI). METHODS This dose-response study was a prospective, randomized, blinded, and placebo-controlled preclinical experiment. Male Wistar adult rats, subjected to mTBI induced by a closed head impact, were treated randomly with 0 (saline as placebo), 0...
January 5, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29302617/genetic-pathways-of-neuroregeneration-in-a-novel-mild-traumatic-brain-injury-model-in-adult-zebrafish
#4
Amanda L Maheras, Brian Dix, Olivia M S Carmo, Aleena E Young, Vanessa N Gill, Julia L Sun, Aleah R Booker, Helen A Thomason, Anastasia E Ibrahim, Lauren Stanislaw, Jennifer C Dallego, Cat N Ngo, Audrey Chen, Barbara K Fortini, Rory D Spence
Mild traumatic brain injuries (mTBIs) are one of the most prevalent neurological disorders, and humans are severely limited in their ability to repair and regenerate central nervous system (CNS) tissue postinjury. However, zebrafish (Danio rerio) maintain the remarkable ability to undergo complete and functional neuroregeneration as an adult. We wish to extend knowledge of the known mechanisms of neuroregeneration by analyzing the differentially expressed genes (DEGs) in a novel adult zebrafish model of mTBI...
January 2018: ENeuro
https://www.readbyqxmd.com/read/29288226/progressive-delayed-hemidystonia-following-clinically-mild-traumatic-brain-injury
#5
Swaleha N Nadaf, Rahul T Chakor, Kaumil Vipul Kothari, Haresh Bharote
A 16-year-old boy presented with progressive left hemidystonia over 3 years. The possibilities of symptomatic hemidystonia due to focal lesions such as infarct (vasculitis), tumours, tuberculoma, arteriovenous malformations or heredodegenerative disorders such as Wilson disease were considered. Imaging showed a peculiar scar involving right basifrontal region extending upto anterior, centromedian and dorsomedial nuclei of thalamus due to blowout fracture of roof of orbit. This scar was responsible for progressive left hemidystonia...
December 28, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29284994/the-role-of-dual-tasking-in-the-assessment-of-gait-cognition-and-community-reintegration-of-veterans-with-mild-traumatic-brain-injury
#6
Azadeh Leland, Kamran Tavakol, Joel Scholten, Debra Mathis, David Maron, Simin Bakhshi
Background: This study focussed on the effect of dual versus single tasking on balance, gait and cognition in veterans with mild traumatic brain injury (mTBI). We examined the correlation between these parameters, with responses to questions on community reintegration activities. Method: 22 male and female veterans (aged 19-65) walked along a narrow and 6.1-meter long path, both at their self-selected and fastest but safe pace under single and dual tasking conditions...
December 2017: Materia Socio-medica
https://www.readbyqxmd.com/read/29284552/retrospective-and-prospective-memory-among-oef-oif-ond-veterans-with-a-self-reported-history-of-blast-related-mtbi
#7
Kathleen F Pagulayan, Holly Rau, Renee Madathil, Madeleine Werhane, Steven P Millard, Eric C Petrie, Brett Parmenter, Sarah Peterson, Scott Sorg, Rebecca Hendrickson, Cindy Mayer, James S Meabon, Bertrand R Huber, Murray Raskind, David G Cook, Elaine R Peskind
OBJECTIVES: To evaluate prospective and retrospective memory abilities in Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), and Operation New Dawn (OND) Veterans with and without a self-reported history of blast-related mild traumatic brain injury (mTBI). METHODS: Sixty-one OEF/OIF/OND Veterans, including Veterans with a self-reported history of blast-related mTBI (mTBI group; n=42) and Veterans without a self-reported history of TBI (control group; n=19) completed the Memory for Intentions Test, a measure of prospective memory (PM), and two measures of retrospective memory (RM), the California Verbal Learning Test-II and the Brief Visuospatial Memory Test-Revised...
December 29, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29283307/using-the-california-verbal-learning-test-second-edition-as-an-embedded-performance-validity-measure-among-individuals-with-tbi-and-individuals-with-psychiatric-disorders
#8
Virginia C Persinger, Douglas M Whiteside, Lyuba Bobova, Seema D Saigal, Marla J Vannucci, Michael R Basso
OBJECTIVE: Among embedded performance validity tests (PVTs), little research addresses the use of Total Hits and Total False Positives from the California Verbal Learning Test, Second Edition (CVLT-II) in spite of low sensitivity, particularly in psychiatric samples. METHOD: This study examined the classification accuracy of these two measures in individuals with psychiatric disorders or mild traumatic brain injury (MTBI). These samples were separated into two groups using the criteria of passing all PVTs versus failing 2 or more PVTs...
December 28, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/29277373/exertional-tolerance-assessments-after-mild-traumatic-brain-injury-a-systematic-review
#9
REVIEW
Catherine Quatman-Yates, Anna Bailes, Sara Constand, Mary Claire Sroka, Katharine Nissen, Brad Kurowski, Jason Hugentobler
OBJECTIVE: The objective of this study was to review the literature to identify and summarize strategies for evaluating responses to physical exertion after mild traumatic brain injury (mTBI) for clinical and research purposes. DATA SOURCES: PubMed and EBSCOHost through December 31, 2016. STUDY SELECTION: Two independent reviewers selected studies based on the following criteria: 1) inclusion of participants with mTBI/concussion, 2) use of a measurement of physiological or psychosomatic response to exertion, 3) a repeatable description of the exertion protocol was provided, 4) a sample of at least 10 participants with a mean age between 8-65 years, and 5) the article was in English...
December 22, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29276216/malva-sylvestris-attenuates-cognitive-deficits-in-a-repetitive-mild-traumatic-brain-injury-rat-model-by-reducing-neuronal-degeneration-and-astrocytosis-in-the-hippocampus
#10
Hailin Qin, Jie Qin, Junmin Hu, He Huang, Lianting Ma
BACKGROUND The aim of our study was to evaluate the effect of Malva sylvestris (MS) on cognitive dysfunction in a repetitive mild traumatic brain injury (MTBI). MATERIAL AND METHODS MTBI was induced in all the study animals by hitting a metallic pendulum near the parietal-occipital area of the skull three times a day for ten days. Animals were treated with MS (250 mg/kg and 500 mg/kg) intragastrically per day for seven consecutive days. Cognitive function was estimated by the Morris water maze (MWM) method...
December 25, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29250027/derivation-of-a-three-biomarker-panel-to-improve-diagnosis-in-patients-with-mild-traumatic-brain-injury
#11
W Frank Peacock, Timothy E Van Meter, Nazanin Mirshahi, Kyle Ferber, Robert Gerwien, Vani Rao, Haris Iqbal Sair, Ramon Diaz-Arrastia, Frederick K Korley
Background: Nearly 5 million emergency department (ED) visits for head injury occur each year in the United States, of which <10% of patients show abnormal computed tomography (CT) findings. CT negative patients frequently suffer protracted somatic, behavioral, and neurocognitive dysfunction. Our goal was to evaluate biomarkers to identify mild TBI (mTBI) in patients with suspected head injury. Methods: An observational ED study of head-injured and control patients was conducted at Johns Hopkins University (HeadSMART)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29249173/long-term-prospective-memory-impairment-following-mild-traumatic-brain-injury-with-loss-of-consciousness-findings-from-the-canadian-longitudinal-study-on-aging
#12
Marc Bedard, Vanessa Taler, Jason Steffener
OBJECTIVE: We aimed to examine the extent to which loss of consciousness (LOC) following mild traumatic brain injury (mTBI) may be associated with impairments in time- and event-based prospective memory (PM). PM is thought to involve executive processes and be subserved by prefrontal regions. Neuroimaging research suggests alterations to these areas of the brain several years after mTBI, particularly if LOC was experienced. However, it remains unclear whether impairments in time- or event-based functioning may persist more than a year after mTBI, and what the link with duration of LOC may be...
December 18, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/29248884/use-of-general-practice-before-and-after-mild-traumatic-brain-injury-a-nationwide-population-based-cohort-study-in-denmark
#13
Stine Fjendbo Galili, Bodil Hammer Bech, Claus Vestergaard, Morten Fenger-Gron, Jakob Christensen, Mogens Vestergaard, Jette Ahrensberg
OBJECTIVES: Traumatic brain injury (TBI) is commonly seen in the emergency department (ED). Approximately 85%-90% of TBIs are mild (mTBI). Some cause symptoms such as headache, dizziness, anxiety, blurred vision, insomnia and concentration difficulties, collectively known as postconcussion syndrome (PCS). Some studies suggest that recovery from mTBI is complete. Others find that symptoms persist for months, even years. The aim of this study was to describe the use of general practice, before and after mTBI, as a proxy for symptoms in a large cohort...
December 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29239280/perceived-injustice-and-its-correlates-after-mild-traumatic-brain-injury
#14
Grant L Iverson, Douglas P Terry, Justin E Karr, William Panenka, Noah D Silverberg
Perceived injustice is a belief that one has been treated unfairly, disrespectfully, and is suffering unnecessarily as a result of another person's actions. Perceived injustice predicts chronic disability after musculoskeletal injury, but to our knowledge, has not been empirically studied in people with mild traumatic brain injuries (MTBIs). We examined perceived injustice and its correlates in patients who were slow to recover from MTBI. Patients (N=102) were recruited from four concussion clinics. The sample was on average 41...
December 14, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29239267/a-retrospective-study-of-predictors-of-return-to-duty-vs-medical-retirement-in-an-active-duty-military-population-with-blast-related-mild-traumatic-brain-injury
#15
Philip A Cook, Thomas M Johnson, Suzanne G Martin, Philip R Gerhman, Seema Bhatnagar, James C Gee
Traumatic Brain Injury (TBI), has been described as the "signature injury" of the Global War on Terror. Explosive blast TBI has become a leading cause of injury as a result of the widespread use of improvised explosive devices in Iraq and Afghanistan. We present a retrospective cross-sectional study of patients with blast-related mild TBI (N=303) seen at the Intrepid Spirit Concussion Recovery Center at Naval Medical Center Camp Lejeune. The objective was to predict outcomes of return to duty (RTD) vs. medical retirement via medical evaluation board (MEB), based on brain imaging, neuropsychological data and history of mTBI...
December 14, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29239261/white-matter-tract-integrity-an-indicator-of-axonal-pathology-after-mild-traumatic-brain-injury
#16
Sohae Chung, Els Fieremans, Xiuyuan Wang, Nuri E Kucukboyaci, Charles J Morton, James S Babb, Prin Amorapanth, Farng-Yang Foo, Dmitry S Novikov, Steven R Flanagan, Joseph F Rath, Yvonne W Lui
We seek to elucidate the underlying pathophysiology of injury sustained after mild traumatic brain injury (MTBI) using multi-shell diffusion MRI, deriving compartment-specific WM tract integrity (WMTI) metrics. WMTI allows a more biophysical interpretation of WM changes by describing microstructural characteristics in both intra- and extra-axonal environments. Thirty-two patients with MTBI within 30 days of injury and twenty-one age- and sex-matched controls were imaged on a 3T MR scanner. Multi-shell diffusion acquisition was performed with 5 b-values (250 - 2500 s/mm<sup>2</sup>) along 6 - 60 diffusion encoding directions...
December 14, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29236167/evaluation-of-the-yield-of-24-h-close-observation-in-patients-with-mild-traumatic-brain-injury-on-anticoagulation-therapy-a-retrospective-multicenter-study-and-meta-analysis
#17
Merelijne A Verschoof, Charlotte C M Zuurbier, Frank de Beer, Jonathan M Coutinho, Evert A Eggink, Björn M van Geel
BACKGROUND/AIMS: Patients with mild traumatic brain injury (mTBI) on anticoagulants have an increased risk of intracranial hemorrhage (ICH). However, consensus is lacking on whether to admit them after normal initial cranial CT. We evaluated the yield of 24-h neurological observation. METHODS: Retrospective multicenter study including adult patients admitted over a 5-year period with mTBI on anticoagulation [therapeutic dose heparin, direct oral anticoagulant, or vitamin K antagonist (VKA) with international normalized ratio (INR) ≥ 1...
December 13, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29215295/quantitative-proteomic-study-reveals-up-regulation-of-camp-signaling-pathway-related-proteins-in-mild-traumatic-brain-injury
#18
Hai Song, Shanhua Fang, Jing Gao, Jiaxong Wang, Zhenzhen Cao, Zeyun Guo, Qiongping Huang, Yongqang Qu, Hu Zhou, Jianyun Yu
Traumatic brain injury (TBI), as a neurological injury, becomes a leading cause of disability and mortality due to lacking effective therapy. About 75% of TBI is mild traumatic brain injury (mTBI). However, the complex molecular mechanisms underlying mTBI pathophysiology remains to be elucidated. In this study, iTRAQ-based quantitative proteomic approach was employed to measure temporal-global proteome changes of rat brain tissues from different time points (1 day, 7 day and 6 months) post single mTBI (smTBI) and repetitive mTBI (rmTBI)...
December 7, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29213487/traumatic-brain-injury-an-eeg-point-of-view
#19
REVIEW
Jéssica Natuline Ianof, Renato Anghinah
Traumatic brain injury (TBI) is a silent epidemic. Mild traumatic brain injury (mTBI) causes brain injury that results in electrophysiologic abnormalities visible on electroencephalography (EEG) recordings. The purpose of this brief review was to discuss the importance of EEG findings in traumatic brain injury. Relevant articles published during the 1996-2016 period were retrieved from Medline (PubMed). The keywords were in English and included "traumatic brain injury", "EEG" and "quantitative EEG". We found 460 articles, analyzed 52 and selected 13 articles...
January 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29213254/blue-light-therapy-following-mild-traumatic-brain-injury-effects-on-white-matter-water-diffusion-in-the-brain
#20
Sahil Bajaj, John R Vanuk, Ryan Smith, Natalie S Dailey, William D S Killgore
Mild traumatic brain injury (mTBI) is a common and often inconspicuous wound that is frequently associated with chronic low-grade symptoms and cognitive dysfunction. Previous evidence suggests that daily blue wavelength light therapy may be effective at reducing fatigue and improving sleep in patients recovering from mTBI. However, the effects of light therapy on recovering brain structure remain unexplored. In this study, we analyzed white matter diffusion properties, including generalized fractional anisotropy, and the quantity of water diffusion in isotropic (i...
2017: Frontiers in Neurology
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