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https://www.readbyqxmd.com/read/28926480/postconcussive-symptoms-over-the-first-14-days-after-mild-traumatic-brain-injury-an-experience-sampling-study
#1
Maria Pacella, Arjun Prabhu, Julia Morley, Stephanie Huang, Brian Suffoletto
OBJECTIVE: This study examined changes in postconcussive symptoms (PCS) over the acute postinjury recovery period, focusing on how daily PCSs differ between mild traumatic brain injury (mTBI) and other injury types. SETTING: An urban emergency department (ED) in Western Pennsylvania. SUBJECTS: A total of 108 adult patients with trauma being discharged from the ED were recruited and grouped by injury type: mild TBI (mTBI; n = 39), head injury without mTBI (HI: n = 16), and non-head-injured trauma controls (TCs: n = 53)...
September 18, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28925734/a-pilot-treatment-study-for-mild-traumatic-brain-injury-neuroimaging-changes-detected-by-meg-after-low-intensity-pulse-based-transcranial-electrical-stimulation
#2
Ming-Xiong Huang, Ashley Robb Swan, Annemarie Angeles Quinto, Scott Matthews, Deborah L Harrington, Sharon Nichols, Barry J Bruder, Corey C Snook, Charles W Huang, Dewleen G Baker, Roland R Lee
BACKGROUND: Mild traumatic brain injury (mTBI) is a leading cause of sustained impairments in military service members, Veterans, and civilians. However, few treatments are available for mTBI, partially because the mechanism of persistent mTBI deficits is not fully understood. METHODS: We used magnetoencephalography (MEG) to investigate neuronal changes in individuals with mTBI following a passive neurofeedback-based treatment programme called IASIS. This programme involved applying low-intensity pulses using transcranial electrical stimulation (LIP-tES) with electroencephalography monitoring...
September 19, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28925716/differential-neural-activation-when-voluntarily-regulating-emotions-in-service-members-with-chronic-mild-traumatic-brain-injury
#3
Michael N Dretsch, Thomas A Daniel, Adam M Goodman, Jeffrey S Katz, Thomas Denney, Gopikrishna Deshpande, Jennifer L Robinson
The objective of this study was to characterize the functional activation of the neural correlates of voluntary regulation of emotion in soldiers both with and without chronic mild traumatic brain injury (mTBI). Using functional magnetic resonance imaging (fMRI) and a battery of cognitive and psychological health measures, we assessed differences between active-duty U.S. soldiers with chronic mTBI (n = 37) and without (Controls, n = 35). Participants were instructed to maintain (passively view), enhance, and suppress emotions associated with negative and neutral visual stimuli...
September 19, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28924170/the-tyrosine-phosphatase-ptpn13-fap-1-links-calpain-2-tbi-and-tau-tyrosine-phosphorylation
#4
Yubin Wang, Randy A Hall, Moses Lee, Andysheh Kamgar-Parsi, Xiaoning Bi, Michel Baudry
Traumatic brain injury (TBI) increases the risk of Alzheimer's disease (AD). Calpain activation and tau hyperphosphorylation have been implicated in both TBI and AD. However, the link between calpain and tau phosphorylation has not been fully identified. We recently discovered that the two major calpain isoforms in the brain, calpain-1 and calpain-2, play opposite functions in synaptic plasticity and neuronal survival/death, which may be related to their different C-terminal PDZ binding motifs. Here, we identify the tyrosine phosphatase PTPN13 as a key PDZ binding partner of calpain-2...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28916167/structural-neuroimaging-in-sport-related-concussion
#5
Erin D Bigler
Structural neuroimaging of athletes who have sustained a sports-related concussion (SRC) can be viewed as either standard clinical imaging or with advanced neuroimaging methods that quantitatively assess brain structure. Negative findings from conventional computed tomography (CT) or magnetic resonance imaging (MRI) are the norm in SRC. Nonetheless, these conventional measures remain the first line of neuroimaging of the athlete as they do detect clinically significant pathologies, when present, such as hemorrhagic abnormalities in the form of hematomas, contusions and mircobleeds along with regions of focal encephalomalacia or other signal abnormalities, with CT best capable of detecting skull fractures...
September 12, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28912698/altered-rich-club-and-frequency-dependent-subnetwork-organization-in-mild-traumatic-brain-injury-a-meg-resting-state-study
#6
Marios Antonakakis, Stavros I Dimitriadis, Michalis Zervakis, Andrew C Papanicolaou, George Zouridakis
Functional brain connectivity networks exhibit "small-world" characteristics and some of these networks follow a "rich-club" organization, whereby a few nodes of high connectivity (hubs) tend to connect more densely among themselves than to nodes of lower connectivity. The Current study followed an "attack strategy" to compare the rich-club and small-world network organization models using Magnetoencephalographic (MEG) recordings from mild traumatic brain injury (mTBI) patients and neurologically healthy controls to identify the topology that describes the underlying intrinsic brain network organization...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28904986/sex-matters-repetitive-mild-traumatic-brain-injury-in-adolescent-rats
#7
David K Wright, Terence J O'Brien, Sandy R Shultz, Richelle Mychasiuk
OBJECTIVE: Whether sex differences contribute to the heterogeneity of mild traumatic brain injury (mTBI) and repeated mTBI (RmTBI) outcomes in adolescents is unknown. Therefore, this study examined changes in, and differences between, male and female rats following single mTBI and RmTBI. METHODS: Rats were given a single mTBI, RmTBI (i.e., 3x), or sham injuries. Injuries were administered using a lateral impact model that mimics forces common in human mTBI. After the final injury, rats underwent extensive behavioral testing to examine cognition, motor function, and anxiety- and depressive-like behavior...
September 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28899613/psychiatric-comorbidity-pattern-in-treatment-seeking-veterans
#8
J Don Richardson, F Ketcheson, L King, P Shnaider, M Marlborough, A Thompson, J D Elhai
OBJECTIVE: To compare physical and mental health outcomes of Canadian military personnel with probable mild traumatic brain injury(mTBI) to outcomes of those without and to report implications for collaboration and treatment. METHODS: One hundred forty-seven soldiers attending the Operational Stress Injury Clinic at Parkwood Hospital, London, Ontario, were screened for mTBI and completed several other measures of mental and physical health. Scores from these measures were compared across two groups (positive vs...
September 1, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28895491/preliminary-validation-of-the-whodas-2-0-for-mild-traumatic-brain-injury
#9
Deborah Snell, Grant L Iverson, William Panenka, Noah D Silverberg
The purpose of this study is to examine the reliability, factor structure, and validity of the World Health Organization Disability Assessment Schedule (WHODAS 2.0 12-item version) in a sample of patients who were slow to recover from a mild traumatic brain injury (MTBI). Participants were 79 adults with MTBI recruited from one of four specialty outpatient clinics in Vancouver, Canada. The WHODAS 2.0 12-item version is a disease-non-specific measure of disability representing six International Classification of Disability, Functioning, and Health activity and participation domains including cognition, mobility, self-care, interpersonal functioning, life activities, and participation...
September 12, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28895451/risk-factors-for-mild-traumatic-brain-injury-and-subsequent-post-traumatic-stress-disorder-and-mental-health-disorders-among-us-army-soldiers
#10
Dennis Edward Scofield, Susan P Proctor, Joseph R Kardouni, Owen T Hill, Craig J McKinnon
To determine the association of mild traumatic brain injury (mTBI) with subsequent Post-traumatic Stress Disorder (PTSD) and mental health disorders (MHD) and the intervening role of Acute Stress Disorder (ASD). This matched case-control study utilized the Total Army Injury and Health Outcomes Database (TAIHOD) to analyze Soldiers' (N=1,261,297) medical encounter data between 2002 and 2011. International Classification of Diseases, Ninth Revision (ICD-9) codes were used to identify: mTBI (following CDC surveillance definition for mTBI), MHD (ICD-9 codes for depression and anxiety, excluding PTSD), PTSD (ICD-9 309...
September 12, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28894835/the-use-of-oculomotor-vestibular-and-reaction-time-tests-to-assess-mild-traumatic-brain-injury-mtbi-over-time
#11
Michael E Hoffer, Carey Balaban, Mikhaylo Szczupak, James Buskirk, Hillary Snapp, James Crawford, Sean Wise, Sara Murphy, Kathryn Marshall, Constanza Pelusso, Sean Knowles, Alex Kiderman
OBJECTIVES: The objective of this work is to examine the outcomes of a set of objective measures for evaluating individuals with minor traumatic brain injury (mTBI) over the sub-acute time period. These methods involve tests of oculomotor, vestibular, and reaction time functions. This work expands upon published work examining these test results at the time of presentation. STUDY DESIGN: This study is a prospective age- and sex-matched controlled study. MATERIALS AND METHODS: The subject group was composed of 106 individuals with mTBI and 300 age- and sex-matched controls without a history of mTBI...
August 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28889832/intra-individual-cognitive-variability-an-examination-of-anam4-tbi-mil-simple-reaction-time-data-from-service-members-with-and-without-mild-traumatic-brain-injury
#12
Wesley R Cole, Emma Gregory, Jacques P Arrieux, F Jay Haran
OBJECTIVES: The Automated Neuropsychological Assessment Metrics 4 TBI-MIL (ANAM4) is a computerized cognitive test often used in post-concussion assessments with U.S. service members (SMs). Existing evidence, however, remains mixed regarding ANAM4's ability to identify cognitive issues following mild traumatic brain injury (mTBI). Studies typically examine ANAM4 by comparing mean scores to baseline or normative scores. A more fine-grained approach involves examining inconsistency within an individual's performance...
September 11, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28882543/longitudinal-study-of-a-nogo-p3-event-related-potential-component-following-mild-traumatic-brain-injury-in-adults
#13
Gian Candrian, Andreas Müller, Patrizia Dall'Acqua, Kyveli Kompatsiari, Gian-Marco Baschera, Ladislav Mica, Hans-Peter Simmen, Richard Glaab, Javier Fandino, Markus Schwendinger, Christoph Meier, Erika Jasmin Ulbrich, Sönke Johannes
BACKGROUND: Event-related potentials have repeatedly revealed electrophysiological markers of cognitive dysfunction associated with Mild Traumatic Brain Injury (MTBI) and may represent a sensitive tool to guide cognitive rehabilitative interventions. We previously found patients with symptomatic MTBI characterized by smaller P300 (or P3) wave amplitudes in a NoGo-P3 subcomponent in the acute phase of the injury. The goal of this longitudinal study was to investigate whether this early NoGo-P3 subcomponent differs over time in symptomatic MTBI patients and healthy controls...
September 4, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28882089/the-default-mode-network-as-a-biomarker-of-persistent-complaints-after-mild-traumatic-brain-injury-a-longitudinal-fmri-study
#14
Harm Jan van der Horn, Myrthe Elisabeth Scheenen, Myrthe Elisabeth de Koning, Edith J Liemburg, Jacoba M Spikman, Joukje van der Naalt
The objective of this study was to examine longitudinal functional connectivity of resting-state networks in patients with and without complaints after uncomplicated mild traumatic brain injury (mTBI). Second, we aimed to determine the value of network connectivity in predicting persistent complaints, anxiety, depression and long-term outcome. Thirty mTBI patients with (≥ 3) posttraumatic complaints at two weeks post-injury, 19 without complaints, and 20 matched healthy controls were selected for this study...
September 7, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28879082/hemodynamic-variability-in-soldiers-with-trauma-implications-for-functional-mri-connectivity-studies
#15
D Rangaprakash, Michael N Dretsch, Wenjing Yan, Jeffrey S Katz, Thomas S Denney, Gopikrishna Deshpande
Functional MRI (fMRI) is an indirect measure of neural activity as a result of the convolution of the hemodynamic response function (HRF) and latent (unmeasured) neural activity. Recent studies have shown variability of HRF across brain regions (intra-subject spatial variability) and between subjects (inter-subject variability). Ignoring this HRF variability during data analysis could impair the reliability of such fMRI results. Using whole-brain resting-state fMRI (rs-fMRI), we employed hemodynamic deconvolution to estimate voxel-wise HRF...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28876149/acute-post-concussive-symptoms-in-young-children
#16
Coco Bernard, Audrey McKinlay, David Krieser, Renee Testa, And Jennie Ponsford
OBJECTIVES: Despite peaks of mild traumatic brain injury (mTBI) incidence in young children, few studies have examined the nature of post-concussive symptoms (PCSs) in children under the age of eight, whilst controlling for pre-injury symptoms and effects of trauma. The current study aimed to identify which PCSs differentiate children with mTBI from trauma controls early post-injury, and whether these differed among preschool and school-aged children. METHODS: The sample comprised 101 children aged 2-12 presenting to an emergency department, with concussion or other minor bodily injury (control)...
September 6, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28876146/effects-of-concomitant-mild-traumatic-brain-injury-on-resuming-work-after-suffering-from-an-isolated-limb-fracture-a-cohort-study
#17
Marianne Jodoin, Dominique M Rouleau, Camille Larson-Dupuis, Benoit Benoit, Stéphane Leduc, G-Yves Laflamme, Nadia Gosselin, Meriem Sabir, Louis De Beaumont
BACKGROUND: The objective is to explore the effects of concomitant mild traumatic brain injury (mTBI) on return to work (RTW), among patients suffering from an isolated limb fracture. This follow-up study included a total of 170 working age subjects with an isolated limb fracture, and was conducted in a phone interview approximately 1-year post trauma. 41 had experienced an mTBI and 129 did not. METHODS: Data were obtained through a phone interview conducted on average 20...
September 6, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28872344/quality-of-return-to-work-in-patients-with-mild-traumatic-brain-injury-a-prospective-investigation-of-associations-among-post-concussion-symptoms-neuropsychological-functions-working-status-and-stability
#18
Shao-Ying Chu, Yi-Hsin Tsai, Sheng-Huang Xiao, Sheng-Jean Huang, Chi-Cheng Yang
PRIMARY OBJECTIVE: Although 'return to work' (RTW) has been always emphasized for patients with mild traumatic brain injury (MTBI), methodological drawbacks weakened its representativeness. This study thus aims to evaluate the 'work quality' (WQ) which originated from 'working status' and 'working stability' simultaneously, and to further explore the associations among post-concussion symptoms (PCS), neuropsychological functions and WQ. METHODS AND PROCEDURES: A total of 179 participants, which included 132 patients with MTBI and 47 healthy participants, were prospectively recruited...
September 5, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28863142/assessing-the-accuracy-of-blood-rna-profiles-to-identify-patients-with-post-concussion-syndrome-a-pilot-study-in-a-military-patient-population
#19
Jimmaline J Hardy, Scott R Mooney, Andrea N Pearson, Dawn McGuire, Daniel J Correa, Roger P Simon, Robert Meller
Mild traumatic brain injury (mTBI) is a complex, neurophysiological condition that can have detrimental outcomes. Yet, to date, no objective method of diagnosis exists. Physical damage to the blood-brain-barrier and normal waste clearance via the lymphatic system may enable the detection of biomarkers of mTBI in peripheral circulation. Here we evaluate the accuracy of whole transcriptome analysis of blood to predict the clinical diagnosis of post-concussion syndrome (PCS) in a military cohort. Sixty patients with clinically diagnosed chronic concussion and controls (no history of concussion) were recruited (retrospective study design)...
2017: PloS One
https://www.readbyqxmd.com/read/28861454/hemodynamic-response-function-parameters-obtained-from-resting-state-functional-mri-data-in-soldiers-with-trauma
#20
D Rangaprakash, Michael N Dretsch, Wenjing Yan, Jeffrey S Katz, Thomas S Denney, Gopikrishna Deshpande
Functional magnetic resonance imaging (fMRI) is an indirect measure of brain activity, i.e. it is a convolution of the latent (unmeasured) neural signal and the hemodynamic response function (HRF). As such, the HRF has been shown to vary across brain regions and individuals. The shape of the HRF is controlled by both neural and non-neural factors. The shape of the HRF can be characterized by three parameters (response height, time-to-peak and full-width at half-max). The data presented here provides the three HRF parameters at every voxel, obtained from U...
October 2017: Data in Brief
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