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https://www.readbyqxmd.com/read/29786762/chronic-conditions-and-multimorbidity-in-a-primary-care-population-a-study-in-the-swiss-sentinel-surveillance-network-sentinella
#1
Markus Gnädinger, Lilli Herzig, Alessandro Ceschi, Dieter Conen, Alfred Staehelin, Marco Zoller, Milo A Puhan
OBJECTIVES: To provide estimates of the prevalence of chronic conditions in Swiss primary care. METHODS: In total, 175 general practitioners (GP) or pediatricians (PED) reporting to the Swiss Sentinel Surveillance Network collected morbidity data. RESULTS: In 26,853 patient contacts, mean (± SD) age was 55.8 ± 21.6 or 6.1 ± 5.7 years (in GPs vs. PEDs, respectively) and 47% were males. In GP patients, median Thurgau Morbidity Index was 2 (IQR 1-3)...
May 21, 2018: International Journal of Public Health
https://www.readbyqxmd.com/read/29785944/-overview-of-the-genetic-control-of-horse-coat-color-patterns
#2
Ruo Yang Zhao, Yi Ping Zhao, Bei Li, Gerelchimeg Bou, Xin Zhuang Zhang, Togtokh Mongke, Tugeqin Bao, Shurenchimeg Gereliin, Tsimbai Gereltuuin, Chao Li, Dong Yi Bai, Mang Lai Dugarjaviin
Mammalian coat color is one of the first phenotypic changes resulting from positive selection by humans, and it serves important roles in genetic and evolutionary processes. Among them, horses show a broad variety of coat color patterns, based on which it is difficult to distinguish the real phenotypes, resulting in confused records in horse breed registration. Thus, research in the genetic mechanisms on the development of coat color patterns is significant in horse reproduction and breeding. With the recent establishment of genomics and sequencing technologies, there are significant advances in research in the genetics of horse coat colors, which demonstrate that special coat colors could be associated with certain diseases...
May 20, 2018: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/29785766/schizophyllum-commune-an-unexploited-source-for-lignocellulose-degrading-enzymes
#3
REVIEW
Omar Eduardo Tovar-Herrera, Adriana Mayrel Martha-Paz, Yordanis Pérez-LLano, Elisabet Aranda, Juan Enrique Tacoronte-Morales, María Teresa Pedroso-Cabrera, Katiushka Arévalo-Niño, Jorge Luis Folch-Mallol, Ramón Alberto Batista-García
Lignocellulose represents the most abundant source of carbon in the Earth. Thus, fraction technology of the biomass turns up as an emerging technology for the development of biorefineries. Saccharification and fermentation processes require the formulation of enzymatic cocktails or the development of microorganisms (naturally or genetically modified) with the appropriate toolbox to produce a cost-effective fermentation technology. Therefore, the search for microorganisms capable of developing effective cellulose hydrolysis represents one of the main challenges in this era...
May 21, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/29785624/longitudinal-neuroimaging-hippocampal-markers-for-diagnosing-alzheimer-s-disease
#4
Carlos Platero, Lin Lin, M Carmen Tobar
Hippocampal atrophy measures from magnetic resonance imaging (MRI) are powerful tools for monitoring Alzheimer's disease (AD) progression. In this paper, we introduce a longitudinal image analysis framework based on robust registration and simultaneous hippocampal segmentation and longitudinal marker classification of brain MRI of an arbitrary number of time points. The framework comprises two innovative parts: a longitudinal segmentation and a longitudinal classification step. The results show that both steps of the longitudinal pipeline improved the reliability and the accuracy of the discrimination between clinical groups...
May 21, 2018: Neuroinformatics
https://www.readbyqxmd.com/read/29785466/effect-of-reassuring-information-about-musculoskeletal-and-mental-health-complaints-at-the-workplace-a-cluster-randomized-trial-of-the-atwork-intervention
#5
Tone Langjordet Johnsen, Hege Randi Eriksen, Valborg Baste, Aage Indahl, Magnus Odeen, Torill Helene Tveito
Purpose The purpose of this study was to investigate the possible difference between the Modified atWork intervention (MAW) and the Original atWork intervention (OAW) on sick leave and other health related outcomes. atWork is a group intervention using the workplace as an arena for distribution of evidence-based knowledge about musculoskeletal and mental health complaints. Methods A cluster randomized controlled trial with 93 kindergartens, comprising a total of 1011 employees, was conducted. Kindergartens were stratified by county and size and randomly allocated to MAW (45 clusters, 324 respondents) or OAW (48 clusters, 313 respondents)...
May 21, 2018: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/29785141/validity-of-a-method-for-the-self-screening-of-cardiovascular-risk
#6
María Barroso, Silvia Pérez-Fernández, M Mar Vila, M Dolors Zomeño, Ruth Martí-Lluch, Ferran Cordon, Rafel Ramos, Roberto Elosua, Irene R Degano, Montse Fitó, Carmen Cabezas, Gemma Salvador, Conxa Castell, María Grau
Background: The validity of a cardiovascular risk self-screening method was assessed. The results obtained for self-measurement of blood pressure, a point-of-care system's assessment of lipid profile and glycated hemoglobin, and a self-administered questionnaire (sex, age, diabetes, tobacco consumption) were compared with the standard screening (gold standard) conducted by a health professional. Methods: Crossover clinical trial on a population-based sample from Girona (north-eastern Spain), aged 35-74, with no cardiovascular disease at recruitment...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29784348/flow-manifold-for-chemical-h-point-standard-addition-method-implemented-to-electrochemical-analysis-based-on-the-capacitance-measurements
#7
Marcin Wieczorek, Maria Madej, Karolina Starzec, Paweł Knihnicki, Anna Telk, Jolanta Kochana, Paweł Kościelniak
The paper presents a novel analytical method for electrochemical potassium determination using gold electrodes with self-assembled thiol monolayers (SATMs) deposited on its surface. The whole analytical procedure was carried out in a dedicated flow manifold using capacitance detection mode. The terminal functional groups on the surface of the dielectric monolayer interacts selectively with the analyte, changing the thickness of the layer depending on the amount of the analyte and the applied voltage, resulting in a change in the registered dielectric capacitance...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784042/neoadjuvant-oxaliplatin-and-capecitabine-combined-with-bevacizumab-plus-radiotherapy-for-locally-advanced-rectal-cancer-results-of-a-single-institute-phase-ii-study
#8
Xin Yu, Qiao-Xuan Wang, Wei-Wei Xiao, Hui Chang, Zhi-Fan Zeng, Zhen-Hai Lu, Xiao-Jun Wu, Gong Chen, Zhi-Zhong Pan, De-Sen Wan, Pei-Rong Ding, Yuan-Hong Gao
BACKGROUND: Neoadjuvant chemoradiotherapy followed by surgery is recommended as the standard of care for locally advanced rectal cancer, reducing local recurrence but not distant metastasis. Intensified systemic therapy is warranted to reduce the risk of distant metastasis. The present study aimed to evaluate the safety and efficacy of neoadjuvant oxaliplatin and capecitabine (XELOX) combined with bevacizumab plus radiotherapy for locally advanced rectal cancer. METHODS: Patients with stages II to III rectal cancer received one cycle of induction chemotherapy and concurrent chemoradiotherapy with XELOX plus bevacizumab...
May 21, 2018: Cancer communications
https://www.readbyqxmd.com/read/29784009/crowd-figure-pictograms-improve-women-s-knowledge-about-mammography-screening-results-from-a-randomised-controlled-trial
#9
Maren Reder, Lau Caspar Thygesen
OBJECTIVE: To evaluate the effect of crowd-figure-pictograms on women's numeric knowledge about mammography screening in a three-armed parallel randomised controlled trial. RESULTS: 552 women were randomised to receive (1) non-numeric information (n = 192), (2) non-numeric and numeric information (n = 186), or (3) non-numeric and numeric information complemented by crowd-figure-pictograms (n = 174). Baseline numeric knowledge was low (control 0.61, numeric 0.66, and pictogram 0...
May 21, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29783148/comparative-study-of-six-sequential-spectrophotometric-methods-for-quantification-and-separation-of-ribavirin-sofosbuvir-and-daclatasvir-an-application-on-laboratory-prepared-mixture-pharmaceutical-preparations-spiked-human-urine-spiked-human-plasma-and-dissolution
#10
Wafaa S Hassan, Manal S Elmasry, Heba M Elsayed, Dalia W Zidan
In accordance with International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) guidelines, six novel, simple and precise sequential spectrophotometric methods were developed and validated for the simultaneous analysis of Ribavirin (RIB), Sofosbuvir (SOF), and Daclatasvir (DAC) in their mixture without prior separation steps. These drugs are described as co-administered for treatment of Hepatitis C virus (HCV). HCV is the cause of hepatitis C and some cancers such as liver cancer (hepatocellular carcinoma) and lymphomas in humans...
May 18, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29782073/a-focus-group-study-exploring-student-nurse-s-experiences-of-an-educational-intervention-focuse-don-working-with-people-with-a-diagnosis-of-personality-disorder
#11
G Stacey, V Baldwin, B Thompson, A Aubeeluck
INTRODUCTION: Negative attitudes exist in practice towards those with a diagnosis of personality disorder. Preregistration training offers the opportunity to address this by developing understanding of the diagnosis, confidence in working with people with the diagnosis and empowering new nurses to challenge prevailing attitudes. Attempts to integrate and evaluate specific educational interventions of this nature into pre-registration nurse education have not been explored elsewhere. AIM: To explore preregistration nurses' experience of a programme of training focused on personality disorder and their perception of its influence on attitudes, understanding of clients and their experience of practice...
May 21, 2018: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/29781949/optn-vascularized-composite-allograft-vca-waiting-list-current-status-and-trends-in-the-united-states
#12
Jennifer L Wainright, Christopher L Wholley, Wida S Cherikh, Jennifer M Musick, David K Klassen
BACKGROUND: Vascularized Composite Allograft (VCA) transplantation is a developing area in the field of transplantation. METHODS: This study used Organ Procurement and Transplantation Network (OPTN) VCA waiting list and transplant data from July 3, 2014 through February 28, 2018 to characterize the OPTN VCA waiting list in terms of composition, removal patterns, waiting time, resulting transplants, and trends over time. RESULTS: Between implementation of the OPTN VCA waiting list on July 3, 2014 and February 28, 2018, 54 candidates - 53...
April 30, 2018: Transplantation
https://www.readbyqxmd.com/read/29781880/willingness-to-donate-organs-among-people-living-with-hiv
#13
Anh Q Nguyen, Saad K Anjum, Samantha E Halpern, Komal Kumar, Sarah E Van Pilsum Rasmussen, Brianna Doby, Ashton A Shaffer, Allan B Massie, Aaron A R Tobian, Dorry L Segev, Jeremy Sugarman, Christine M Durand
BACKGROUND: With passage of the HIV Organ Policy Equity (HOPE) Act, people living with HIV (PLWH) can donate organs to PLWH awaiting transplant. Understanding knowledge and attitudes regarding organ donation among PLWH in the US is critical to implementing the HOPE Act. METHODS: PLWH were surveyed regarding their knowledge, attitudes, and beliefs about organ donation and transplantation at an urban academic HIV clinic in Baltimore, MD between 08/2016-10/2016. Responses were compared using Fisher's exact and chi-squared tests...
May 16, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29781227/body-mass-index-standard-deviation-score-and-obesity-in-children-with-type-1-diabetes-in-the-nordic-countries-hba-1c-and-other-predictors-of-increasing-bmisds
#14
N H Birkebaek, J Kahlert, R Bjarnason, A K Drivvoll, A Johansen, E Konradsdottir, A Pundziute-Lyckå, U Samuelsson, T Skrivarhaug, J Svensson
BACKGROUND: Intensified insulin therapy may increase body weight and cause obesity. This study compared body mass index standard deviation score (BMISDS) and obesity rate in children with type 1 diabetes (T1D) in Denmark, Iceland, Norway and Sweden, and uncovered predictors for increasing BMISDS. METHODS: Data registered in the Nordic national childhood diabetes databases during the period 2008-2012 on children below 15 years with T1D for more than three months were compiled, including information on gender, age, diabetes duration, HbA1c , insulin dose, severe hypoglycemia (SH), treatment modality, height and weight...
May 21, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29780414/antibiotic-prophylaxis-with-trimethoprim-sulfamethoxazole-versus-no-treatment-after-mid-to-distal-hypospadias-repair-a-prospective-randomized-study
#15
Elizabeth B Roth, John V Kryger, Charles T Durkee, Melissa A Lingongo, Ruth M Swedler, Travis W Groth
Purpose: To evaluate the impact of prophylactic antibiotics after distal hypospadias repair on postoperative bacteriuria, symptomatic urinary tract infection, and postoperative complications in a prospective, randomized trial. Materials and Methods: Consecutive patients aged 6 months to 2 years were enrolled at our institution between June 2013 and May 2017. Consenting patients were randomized to antibiotic prophylaxis with trimethoprim-sulfamethoxazole versus no antibiotic...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29779983/outcomes-of-a-randomized-trial-evaluating-two-approaches-for-promoting-pharmacy-based-referrals-to-the-tobacco-quitline
#16
Karen Suchanek Hudmon, Robin L Corelli, Carl de Moor, Alan J Zillich, Christine Fenlon, Lyndsay Miles, Alexander V Prokhorov, Susan M Zbikowski
OBJECTIVES: To evaluate the long-term impact of 2 promising intervention approaches to engage pharmacy personnel (pharmacists, technicians) in referring patients who want to quit smoking to the tobacco quitline. DESIGN: Randomized trial. SETTING: Community pharmacies in Connecticut (n = 32) and Washington (n = 32). INTERVENTION: Two intervention approaches were evaluated: academic detailing (AD), which involved on-site training for pharmacy staff about the quitline, versus mailed quitline materials (MM)...
May 17, 2018: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/29779971/bifurcation-and-ostial-optical-coherence-tomography-mapping-boom-case-description-of-a-novel-bifurcation-stent-technique
#17
Evan Shlofmitz, Fernando Sosa, Alec Goldberg, Akiko Maehara, Ziad A Ali, Gary S Mintz, Jeffery W Moses, Gregg W Stone, Richard A Shlofmitz, Allen Jeremias
Stent placement guided by angiography alone is often inexact, but of increased importance with bifurcation percutaneous coronary intervention (PCI). We describe a novel technique using optical coherence tomography (OCT)-guided angiographic co-registration termed "Bifurcation and Ostial OCT Mapping" (BOOM). The technique is based on the precise identification and mapping of the side-branch ostium using co-registration to minimize protrusion of stent struts into the main branch while ensuring full coverage of the ostium in the side-branch...
May 6, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29779859/-rapidly-growing-squamous-cell-carcinoma-after-ingenol-mebutate-treatment
#18
M Ehret, C Velter, M Tebacher, C Bruant-Rodier, B Cribier
INTRODUCTION: Ingenol mebutate is an actinic keratosis treatment, which has a dual action mechanism. It allows a rapid cellular death and a severe inflammation. OBSERVATION: We report the case of a 75 years old patient with a rapidly growing tumor 5 weeks after application of ingenol mebutate on typical actinic keratosis. Histological analysis after surgical excision showed an invasive squamous cell carcinoma (SCC); with aggressiveness signs: perineural infiltration and vascular permeation...
May 17, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29779723/checking-the-potential-shift-to-perceived-usefulness-the-analysis-of-users-response-to-the-updated-electronic-health-record-core-features
#19
Petar Rajković, Dejan Aleksić, Dragan Janković, Aleksandar Milenković, Ivan Petković
OBJECTIVE: The primary objective of this paper is to identify the main factors which have an impact on the users' attitude towards the functionalities representing the perceived ease of use and to those representing the perceived usefulness. Another objective is to examine whether there occurred a shift towards the perceived usefulness of users' behavior over a period of time. To support these objectives, two different cases are examined - the case in which users are simultaneously offered basic and updated functionalities, and the one in which users are offered a completely new set of features...
July 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29779623/educating-emergency-department-staff-on-the-identification-and-treatment-of-human-trafficking-victims
#20
Steven Donahue, Michael Schwien, Danielle LaVallee
INTRODUCTION: Hospitalization is one of the few circumstances in which the lives of trafficking victims intersect with the general population. Based on survivor testimonies, the majority of human trafficking victims may receive medical treatment in a hospital's emergency department while in captivity. With evidenced-based training, ED personnel have a better opportunity to screen persons who are being trafficked and intervene on their behalf. METHODS: This project examined the efficacy of an innovative, evidence-based online training module (HTEmergency...
May 17, 2018: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
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