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https://www.readbyqxmd.com/read/28938657/a-network-meta-analysis-on-the-efficacy-of-targeted-agents-in-combination-with-chemotherapy-for-treatment-of-advanced-metastatic-triple-negative-breast-cancer
#1
Long Ge, Yan Tang, Qiu-Ning Zhang, Jin-Hui Tian, Xiao-Hu Wang, Dawid Pieper, Bei Pan, Lun Li, Juan Ling, Zhi-Tong Bing, Ke-Hu Yang
OBJECTIVE: Our network meta-analysis aimed to determine the assistant efficacy of targeted therapy in combined with chemotherapy for advanced/metastatic triple-negative breast cancer (TNBC). RESULTS: A total of 15 randomized controlled trials (RCTs), involving 2,410 patients, met our inclusion criteria. Eight targeted agents involving 11 treatment arms were included. The methodological quality of included RCTs was acceptable. The results of direct comparisons showed that progression-free survival (PFS) was significantly longer with bevacizumab+chemotherapy when compared to chemotherapy alone (hazard ratio [HR] = 0...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938498/-loudness-optimized-registration-of-compound-action-potential-in-cochlear-implant-recipients
#2
Klaus Berger, Thomas Hocke, Horst Hessel
Background Postoperative measurements of compound action potentials are not always possible due to the insufficient acceptance of the CI-recipients. This study investigated the impact of different parameters on the acceptance of the measurements. Methods Compound action potentials of 16 CI recipients were measured with different pulse-widths. Recipients performed a loudness rating at the potential thresholds with the different sequences. Results Compound action potentials obtained with higher pulse-widths were rated softer than those obtained with smaller pulse-widths...
September 22, 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28937489/a-novel-registration-based-semiautomatic-mandible-segmentation-pipeline-using-computed-tomography-images-to-study-mandibular-development
#3
Ying Ji Chuang, Benjamin M Doherty, Nagesh Adluru, Moo K Chung, Houri K Vorperian
OBJECTIVE: We present a registration-based semiautomatic mandible segmentation (SAMS) pipeline designed to process a large number of computed tomography studies to segment 3-dimensional mandibles. METHOD: The pipeline consists of a manual preprocessing step, an automatic segmentation step, and a final manual postprocessing step. The automatic portion uses a nonlinear diffeomorphic method to register each preprocessed input computed tomography test scan on 54 reference templates, ranging in age from birth to 19 years...
September 20, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28937240/baroreflex-sensitivity-in-premature-infants-relation-to-the-parameters-characterizing-intrauterine-and-postnatal-condition
#4
K Haskova, M Javorka, B Czippelova, M Zibolen, K Javorka
At present, there are insufficient information about baroreflex sensitivity (BRS) and factors that determine BRS in premature newborns. The objective of this study was to determine the relationship between BRS and the characteristics that reflecting the intrauterine development (gestational age and birth weight), as well as postnatal development (postconception age and the actual weight of the child at the time of measurement). We examined 57 premature infants, who were divided into groups according to gestational age and postconception age as well as birth weight, and weight at the time of measurement...
September 22, 2017: Physiological Research
https://www.readbyqxmd.com/read/28936832/-clinical-medication-characteristics-of-shuxuening-injection-in-treatment-of-cerebral-infarction-research-based-on-registration
#5
Jun-Jie Jiang, Yan-Ming Xie, Yin Zhang, Yi-Kai Zhang, Zuo-Ming Wang, Bing Han
To understand the medication characteristics of Xingxue@Shuxuening solutions in the real world, multi-center, large-sample-size registration design method is adopted in this study. Between October 2012 and October 2015, hospitalized patients in 27 medical institutions who used Shuxuening and diagnosed as cerebral infarction were observed, including their general information, diagnosis information and medication information. Totally 9 473 cases of cerebral infarction were included, with old people as the majority, and males were slightly more men than females; they were complicated with coronary heart disease, vertebrobasilar artery insufficiency, transient brain ischemia and other cerebrovascular diseases; the medication duration was mostly within 14 days; the dosage was mainly 8-20 mL; 0...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28936830/-registration-of-30-026-cases-of-shenqi-fuzheng-injection-combined-with-other-drugs-in-real-world
#6
Lian-Xin Wang, Yan-Ming Xie, Qing-Hua Ai, Qian Feng
Prospective, multi-center, large-sample and registered design was used to analyze the drug combination features of Shenqi Fuzheng injection in the real world clinical application, and comprehend the drug combination in the real world. A total of 30 026 patients with the use of Shenqi Fuzheng injection were registered, where the chemical drugs were used for 57 436 times (accounting for 82.76%), and the Chinese patent medicines were used for 11 962 times (accounting for 17.24%), mainly including anti-acid drugs and anti-ulcer drugs, nutritional agent, immune enhancement agent, etc...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28936675/reconnection-to-mechanical-ventilation-for-1%C3%A2-h-after-a-successful-spontaneous-breathing-trial-reduces-reintubation-in-critically-ill-patients-a-multicenter-randomized-controlled-trial
#7
M Mar Fernandez, Alejandro González-Castro, Monica Magret, M Teresa Bouza, Marcos Ibañez, Carolina García, Begoña Balerdi, Arantxa Mas, Vanesa Arauzo, José M Añón, Francisco Ruiz, José Ferreres, Roser Tomás, Marta Alabert, Ana Isabel Tizón, Susana Altaba, Noemi Llamas, Rafael Fernandez
BACKGROUND: Spontaneous breathing trials (SBT) can be exhausting, but the preventive role of rest has never been studied. This study aimed to evaluate whether reconnection to mechanical ventilation (MV) for 1 h after the effort of a successful SBT could reduce the need for reintubation in critically ill patients. METHODS: Randomized multicenter trial conducted in 17 Spanish medical-surgical intensive care units (Oct 2013-Jan 2015). Patients under MV for longer than 12 h who fulfilled criteria for planned extubation were randomly allocated after a successful SBT to direct extubation (control group) or reconnection to the ventilator for a 1-h rest before extubation (rest group)...
September 22, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28936489/landmark-based-alzheimer-s-disease-diagnosis-using-longitudinal-structural-mr-images
#8
Jun Zhang, Mingxia Liu, Le An, Yaozong Gao, Dinggang Shen
In this paper, we propose a landmark-based feature extraction method for AD diagnosis using longitudinal structural MR images, which requires no nonlinear registration or tissue segmentation in the application stage and is robust to the inconsistency among longitudinal scans. Specifically, (1) the discriminative landmarks are first automatically discovered from the whole brain, which can be efficiently localized using a fast landmark detection method for the testing images; (2) High-level statistical spatial features and contextual longitudinal features are then extracted based on those detected landmarks...
October 2016: Bayesian and Graphical Models for Biomedical Imaging: BAMBI 2014
https://www.readbyqxmd.com/read/28936399/rising-rate-of-liver-transplantation-in-the-baby-boomer-generation-with-non-alcoholic-steatohepatitis-in-the-united-states
#9
Osama Siddique, Mairin Joseph-Talreja, Eric R Yoo, Ryan B Perumpail, George Cholankeril, Stephen A Harrison, Zobair M Younossi, Robert J Wong, Aijaz Ahmed
Background and Aims: Nonalcoholic steatohepatitis (NASH) is the most rapidly growing indication for liver transplantation (LT) in the United States and is on a trajectory to become the leading indication for LT in the next decade. We aimed to study the trends in NASH-related LT among persons born between 1945 and 1965, the baby boomer (BB) generation. Methods: We performed a retrospective cohort analysis using population-based data from the United Network for Organ Sharing/Organ Procurement and Transplantation Network registry from 2004-2015 to evaluate the birth cohort-specific trends in liver transplant waitlist registrations and liver transplant surgeries in patients with NASH...
September 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/28935831/anti-inflammatory-approaches-to-ischaemic-stroke-prevention
#10
REVIEW
Peter J Kelly, Sean Murphy, Sarah Coveney, Francisco Purroy, Robin Lemmens, Georgios Tsivgoulis, Chris Price
Stroke is a major cause of neurological morbidity and mortality. Atherosclerosis is a major contributor to first and recurrent stroke. A growing evidence base indicates that inflammation is a key process in the pathogenesis of atherosclerosis, leading to thromboembolic events. In this review, we summarise the evidence linking inflammation to stroke risk and discuss clinical trials addressing the 'inflammation hypothesis' in coronary disease and stroke.Trial registration number CONVINCE trial ClinicalTrials...
September 21, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28935463/image-guidance-for-transcatheter-aortic-valve-implantation-tavi-and-cerebral-embolic-protection
#11
I Vernikouskaya, W Rottbauer, B Gonska, C Rodewald, J Seeger, V Rasche, J Wöhrle
The study was aimed at evaluation of the feasibility and potential benefit of image fusion (IF) of pre-procedural CT angiography (CTA) and x-ray (XR) fluoroscopy for image-guided navigation in transfemoral transcatheter aortic valve implantation (TAVI) with the strong focus on guiding the double-filter cerebral embolic protection device and valve prosthesis placement. METHODS: In 31 patients undergoing TAVI, image registration of CTA-derived 3D anatomical models of the relevant cardiac anatomy and vasculature, and live XR was performed applying a commercially available navigation tool...
September 19, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28935457/-development-and-implementation-of-an-outpatient-clinic-at-an-initial-reception-centre-for-asylum-seekers-in-the-german-federal-state-of-baden-wuerttemberg
#12
C Nikendei, D Huhn, G Adler, P Becker von Rose, T M Eckstein, B Fuchs, S C Gewalt, B Greiner, T Günther, W Herzog, T Junghanss, T Krczal, D Lorenzen, T Lutz, M A Manigault, N Reinhart, M Rodenberg, I Schelletter, J Szecsenyi, R Steen, C Straßner, M Thomsen, K Wahedi, K Bozorgmehr
In 2015, more than 890,000 asylum seekers were registered in Germany. The provision of medical and psychosocial care for asylum seekers is facing numerous obstacles. Access to health care is mostly insufficient, particularly in initial reception centres. The present article describes the development and implementation of an interdisciplinary outpatient clinic for asylum seekers at the main registration authority in the state of Baden-Wuerttemberg operated by physicians of the University Hospital of Heidelberg and the local Medical Association in Heidelberg...
September 19, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28935453/intraoperative-real-time-tissue-elastography-during-laparoscopic-hepatectomy
#13
Yuta Kobayashi, Kiyohiko Omichi, Yoshikuni Kawaguchi, Junichi Arita, Nobuhisa Akamatsu, Junichi Kaneko, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo
BACKGROUND: Real-time tissue elastography during open hepatectomy facilitates the differential diagnosis of liver tumors by providing information on elasticity. This study investigated the utility of intraoperative real-time tissue elastography (IORTE) during laparoscopic hepatectomy (LH). METHODS: Between 2012 and 2014, IORTE was performed during LH for 21 hepatocellular carcinomas (HCCs), 16 adenocarcinomas and 5 other tumors in 32 patients. The elasticity images were classified into six categories according to the modified criteria on the elasticity type of liver tumors, in which type 1 tumors show more strain than the surrounding liver and type 6 tumors no strain...
September 18, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28935421/stimtrack-an-open-source-software-for-manual-transcranial-magnetic-stimulation-coil-positioning
#14
Emilia Ambrosini, Simona Ferrante, Mark van de Ruit, Stefano Biguzzi, Vera Colombo, Marco Monticone, Giorgio Ferriero, Alessandra Pedrocchi, Giancarlo Ferrigno, Michael J Grey
BACKGROUND: During Transcranial Magnetic Stimulation (TMS) experiments researchers often use a neuronavigation system to precisely and accurately maintain coil position and orientation. NEW METHOD: This study aimed to develop and validate an open-source software for TMS coil navigation. StimTrack uses an optical tracker and an intuitive user interface to facilitate the maintenance of position and orientation of any type of coil within and between sessions. Additionally, online access to navigation data is provided, hereby adding e...
September 18, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28934941/folic-acid-usage-and-associated-factors-in-the-prevention-of-neural-tube-defects-among-pregnant-women-in-ethiopia-cross-sectional-study
#15
Meselech Ambaw Dessie, Ejigu Gebeye Zeleke, Shimelash Bitew Workie, Ayanaw Worku Berihun
BACKGROUND: Neural tube defects are among the most common birth defects, contributing to miscarriage, infant mortality, severe congenital abnormalities and serious disabilities. It is burdensome to patients, caregivers, healthcare systems and society. It could be reduced if women consume a folic acid supplement before and during the early weeks of pregnancy. This study assesses folic acid usage and associated factors for the prevention of neural tube defects among pregnant women in Ethiopia...
September 21, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28934779/what-are-the-predictors-of-altered-central-pain-modulation-in-chronic-musculoskeletal-pain-populations-a-systematic-review
#16
Jacqui Clark, Jo Nijs, Gillian Yeowell, Peter Charles Goodwin
BACKGROUND: Altered central pain modulation is the predominant pain mechanism in a proportion of chronic musculoskeletal pain disorders and is associated with poor outcomes. Although existing studies predict poor outcomes such as persistent pain and disability, to date there is little consensus on what factors specifically predict altered central pain modulation. OBJECTIVES: To review the existing literature on the predictive factors specifically for altered central pain modulation in musculoskeletal pain populations...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934516/large-scale-analysis-evaluating-regional-variability-in-the-request-of-laboratory-tests-in-primary-care-and-its-potential-economic-impact
#17
Maria Salinas, Maite López-Garrigós, Emilio Flores, Carlos Leiva-Salinas
Objective: To compare the ratios of requests of aspartate aminotransferase (AST) to alanine aminotransferase (ALT) and urea to creatinine (Crea); to investigate the variability among regions and to calculate the potential savings if a target is reached. Methods: Laboratories were invited to fill out a registration form on the number of AST, ALT, Urea and Crea requested in 2014, and to provide the reagent price of urea and AST. AST:ALT and Urea:Crea were calculated and compared; also compared were potential savings if each laboratory would have reached the target...
August 1, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/28934166/is-branched-chain-amino-acids-supplementation-an-efficient-nutritional-strategy-to-alleviate-skeletal-muscle-damage-a-systematic-review
#18
REVIEW
Alexandre Fouré, David Bendahan
Amino acids and more precisely, branched-chain amino acids (BCAAs), are usually consumed as nutritional supplements by many athletes and people involved in regular and moderate physical activities regardless of their practice level. BCAAs have been initially shown to increase muscle mass and have also been implicated in the limitation of structural and metabolic alterations associated with exercise damage. This systematic review provides a comprehensive analysis of the literature regarding the beneficial effects of BCAAs supplementation within the context of exercise-induced muscle damage or muscle injury...
September 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28934157/complete-systematic-error-model-of-ssr-for-sensor-registration-in-atc-surveillance-networks
#19
Ángel J Jarama, Jaime López-Araquistain, Gonzalo de Miguel, Juan A Besada
In this paper, a complete and rigorous mathematical model for secondary surveillance radar systematic errors (biases) is developed. The model takes into account the physical effects systematically affecting the measurement processes. The azimuth biases are calculated from the physical error of the antenna calibration and the errors of the angle determination dispositive. Distance bias is calculated from the delay of the signal produced by the refractivity index of the atmosphere, and from clock errors, while the altitude bias is calculated taking into account the atmosphere conditions (pressure and temperature)...
September 21, 2017: Sensors
https://www.readbyqxmd.com/read/28933724/an-automatic-multi-target-independent-analysis-framework-for-non-planar-infrared-visible-registration
#20
Xinglong Sun, Tingfa Xu, Jizhou Zhang, Zishu Zhao, Yuankun Li
In this paper, we propose a novel automatic multi-target registration framework for non-planar infrared-visible videos. Previous approaches usually analyzed multiple targets together and then estimated a global homography for the whole scene, however, these cannot achieve precise multi-target registration when the scenes are non-planar. Our framework is devoted to solving the problem using feature matching and multi-target tracking. The key idea is to analyze and register each target independently. We present a fast and robust feature matching strategy, where only the features on the corresponding foreground pairs are matched...
July 26, 2017: Sensors
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