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Atypical pneumonia

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https://www.readbyqxmd.com/read/27909995/solithromycin-a-novel-fluoroketolide-for-the-treatment-of-community-acquired-bacterial-pneumonia
#1
REVIEW
George G Zhanel, Erika Hartel, Heather Adam, Sheryl Zelenitsky, Michael A Zhanel, Alyssa Golden, Frank Schweizer, Bala Gorityala, Philippe R S Lagacé-Wiens, Andrew J Walkty, Alfred S Gin, Daryl J Hoban, Joseph P Lynch, James A Karlowsky
Solithromycin is a novel fluoroketolide developed in both oral and intravenous formulations to address increasing macrolide resistance in pathogens causing community-acquired bacterial pneumonia (CABP). When compared with its macrolide and ketolide predecessors, solithromycin has several structural modifications which increase its ribosomal binding and reduce its propensity to known macrolide resistance mechanisms. Solithromycin, like telithromycin, affects 50S ribosomal subunit formation and function, as well as causing frame-shift errors during translation...
December 1, 2016: Drugs
https://www.readbyqxmd.com/read/27909896/detection-of-shigella-sonnei-in-a-respiratory-specimen-in-a-patient-with-subacute-atypical-pneumonia
#2
Hiwa Nahid, Désirée Staub, Herbert Hächler, Werner C Albrich
BACKGROUND: Pneumonia caused by shigellosis with or without typical dysentery in immunocompetent patients is an uncommon entity. CASE REPORT: We describe a case of pneumonia in an immunocompetent, previously healthy middle-aged man from Switzerland without relevant travel history which was presumably caused by Shigella sonnei. He was originally admitted for suspected lung cancer. The clinical picture was remarkable as the patient presented with cough and purulent sputum production, but otherwise no classical signs of pneumonia...
December 1, 2016: Infection
https://www.readbyqxmd.com/read/27909284/-organizing-pneumonia-with-high-radiotracer-concentration-on-fluorodeoxyglucose-positron-emission-tomography-mimicking-pleural-dissemination-of-lung-cancer-report-of-a-case
#3
Takahisa Matsuoka, Tetsu Yamada, Shinjiro Nagai, Katsunari Matsuoka, Mitsuhiro Ueda, Yoshihiro Miyamoto
A 68-year-old man was referred to our hospital because of an abnormal shadow in the chest roentgenogram. Chest computed tomography (CT) showed the nodule in the right upper lobe (S3), 17 mm in size. One month later, fluorodeoxyglucose-positron emission tomography (FDG-PET)/CT scanning revealed positive reaction in the right upper lobe lesion and new lesion close to another lobe. In addition, interloblar small nodules were detected, 5 mm and 7 mm in size. A transbronchial brush cytology by bronchoscopy was performed, and the microscopic findings demonstrated the presence of atypical cells, suspected adenocarcinoma...
December 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/27858147/evolution-and-function-of-the-mycoplasma-hyopneumoniae-peroxiredoxin-a-2-cys-like-enzyme-with-a-single-cys-residue
#4
Taylor Gonchoroski, Veridiana G Virginio, Claudia E Thompson, Jéssica A Paes, Cláudio X Machado, Henrique B Ferreira
The minimal genome of the mollicute Mycoplasma hyopneumoniae, the etiological agent of porcine enzootic pneumonia, encodes a limited repertoire of antioxidant enzymes that include a single and atypical peroxiredoxin (MhPrx), whose evolution and function were studied here. MhPrx has only one catalytic cysteine, in contrast with some of its possible ancestors (2-Cys peroxiredoxins), which have two. Although it is more similar to 2-Cys orthologs, MhPrx can still function with a single peroxidatic cysteine (CysP), using non-thiolic electron donors to reduce it...
November 17, 2016: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/27852233/two-unusual-cases-of-successful-treatment-of-hypermucoviscous-klebsiella-pneumoniae-invasive-syndrome
#5
Hiroki Namikawa, Koichi Yamada, Hiroki Fujimoto, Ken-Ichi Oinuma, Yoshihiro Tochino, Yasuhiko Takemoto, Yukihiro Kaneko, Taichi Shuto, Hiroshi Kakeya
BACKGROUND: A few Japanese cases of hypermucoviscous Klebsiella pneumoniae (K. pneumoniae) invasive syndrome have recently been reported. Although extrahepatic complications from bacteremic dissemination have been observed, infected aneurysms are rare. Furthermore, the primary source of infection is generally a liver abscess, and is rarely the prostate. Therefore, we report two atypical cases of hypermucoviscous K. pneumoniae invasive syndrome. CASE PRESENTATION: The first case was an 81-year-old Japanese man with no significant medical history, who was referred to our hospital for vision loss in his right eye...
November 16, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27830112/mycoplasma-pneumonia-with-persistent-lymphadenopathy-and-severe-cold-agglutinin-haemolysis
#6
Mit Shah, Sajid Khan, Kenneth Chan
Mycoplasma pneumonia is an atypical pneumonia commonly affecting young patients with generally mild clinical course. We present a case of a 66-year-old female presenting with weight loss, night sweats and low-grade pyrexia. She acquired symptomatic haemolytic anaemia requiring blood transfusion, markedly raised erythrocyte sedimentation rate (ESR) to 114 mm/hr and extensive peri-hilar lymphadenopathy on computed tomography (CT) scan. After excluding malignancy and granulomatous diseases, she made good recovery although a 4 week follow-up CT scan showed persistent but resolving lymphadenopathy...
2016: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27821087/comparing-culture-and-molecular-methods-for-the-identification-of-microorganisms-involved-in-necrotizing-soft-tissue-infections
#7
Vibeke Børsholt Rudkjøbing, Trine Rolighed Thomsen, Yijuan Xu, Rachael Melton-Kreft, Azad Ahmed, Steffen Eickhardt, Thomas Bjarnsholt, Steen Seier Poulsen, Per Halkjær Nielsen, Joshua P Earl, Garth D Ehrlich, Claus Moser
BACKGROUND: Necrotizing soft tissue infections (NSTIs) are a group of infections affecting all soft tissues. NSTI involves necrosis of the afflicted tissue and is potentially life threatening due to major and rapid destruction of tissue, which often leads to septic shock and organ failure. The gold standard for identification of pathogens is culture; however molecular methods for identification of microorganisms may provide a more rapid result and may be able to identify additional microorganisms that are not detected by culture...
November 8, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27818546/tomography-patterns-of-lung-disease-in-systemic-sclerosis
#8
REVIEW
Andréa de Lima Bastos, Ricardo de Amorim Corrêa, Gilda Aparecida Ferreira
Currently, lung impairment is the leading factor responsible for the morbidity and mortality associated with systemic sclerosis. Therefore, the recognition of the various tomography patterns becomes decisive in the clinical management of these patients. In high-resolution computed tomography studies, the most common pattern is that of nonspecific interstitial pneumonia. However, there are other forms of lung involvement that must also be recognized. The aim of this study was to review the literature on the main changes resulting from pulmonary involvement in systemic sclerosis and the corresponding radiological findings, considering the current classification of interstitial diseases...
September 2016: Radiologia Brasileira
https://www.readbyqxmd.com/read/27806553/a-survey-of-acute-q-fever-among-patients-with-brucellosis-like-and-atypical-pneumonia-symptoms-who-are-referred-to-qaemshahr-razi-hospital-in-northern-iran-2014-2015
#9
Roya Ghasemian, Ehsan Mostafavi, Saber Esmaeili, Narges Najafi, Sara Arabsheybani
INTRODUCTION: Coxiella burnetii is the etiologic agent of the zoonotic disease of Q fever which causes lots of morbidities and mortalities every year. The main route of human infection is inhalation of contaminated aerosols; however, consumption of contaminated dairy products is the second cause. Mazandaran province is one of the main livestock centers of the country and consumption of raw dairy in the region is quite common. There isn't any data about Q fever incidence in this region...
August 26, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27803757/aspiration-related-organizing-pneumonia-complicating-laparoscopic-adjustable-gastric-banding-a-lung-cancer-mimicker
#10
Ahmed A Aljohaney, Amr M Ajlan, Fahad A Alghamdi
There are several described pulmonary complications due to laparoscopic adjustable gastric banding. We report a rare case of a 32-year-old male who presented with pulmonary symptoms and a solitary lung mass 12 years after laparoscopic adjustable gastric banding. A bronchoscopic lung biopsy showed organizing pneumonia that was induced by aspiration pneumonia. The atypical radiological appearance of the aspiration pneumonia may pose a diagnostic challenge, and clinicians' awareness regarding such an entity is needed to avoid unnecessary intervention...
October 2016: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/27803507/role-of-atypical-bacteria-in-hospitalized-patients-with-nursing-home-acquired-pneumonia
#11
Laura Meyer-Junco
Background: Nursing home-acquired pneumonia (NHAP) has been identified as one of the leading causes of mortality and hospitalization for long-term care residents. However, current and previous pneumonia guidelines differ on the appropriate management of NHAP in hospitalized patients, specifically in regard to the role of atypical bacteria such as Chlamydiae pneumonia, Mycoplasma pneumoniae, and Legionella. Objectives: The purpose of this review is to evaluate clinical trials conducted in hospitalized patients with NHAP to determine the prevalence of atypical bacteria and thus the role for empiric antibiotic coverage of these pathogens in NHAP...
October 2016: Hospital Pharmacy
https://www.readbyqxmd.com/read/27801489/diagnostic-value-of-the-bronchoalveolar-lavage-in-interstitial-lung-disease
#12
Mona Mlika, Mouna Ben Kilani, Anissa Berraies, Emna Braham, Agnes Hamzaoui, Faouzi Mezni
Background The bronchoalveolar lavage (BAL) cellular analysis is an invasive method of exploration of the lung. Its diagnostic value in interstitial lung disease (ILD) is integrated to a multi-disciplianry approach implicating clinicians, radiologists and pathologists. Aim We targeted to evaluate the diagnostic value of the BAL. Methods We reported a retrospective study about patients hospitalized for an ILD since the 1st January 2011 to the 31th December 2013. Thirty three patients were admitted in the Department of Pulmonology and the BAL analyses were studied in the Department of Pathology of the same hospital...
May 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/27799827/case-report-of-atypical-still-s-disease-a-diagnosis-of-exclusion
#13
Sandeep Yerra, Letlhogonolo Tlhabano, Tejaswini Vasamsetty
INTRODUCTION: We present an unusual presentation of a 39-year-old man with myalgias and shortness of breath. CHIEF COMPLAINTS: The patient presented to the emergency department with complaints of myalgias, shortness of breath and palpitations. During this hospitalization, he had multiple episodes of tachycardia and desaturation. The patient had elevated troponins and creatinine kinase. Differential diagnosis included pericarditis, pneumonia and malignancy. INVESTIGATIONS: The patient had elevated ferritin and erythrocyte sedimentation rate...
2016: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/27797349/clinical-case-of-the-month-a-64-year-old-woman-presenting-with-fever-confusion-ophthalmoplegia-and-pneumonia
#14
Daniel H Johnson, Michael Modica, Rachel Coleman, Charles V Sanders, Fred A Lopez
Legionella pneumophila is a major cause of atypical community-acquired pneumonia, which is commonly severe enough to require hospitalization. Though primarily a respiratory infection, Legionellosis involves the central nervous system (CNS) in up to 50% of patients, and diagnosis can be obscured by the absence of obvious respiratory symptomatology. A reversible diffuse encephalopathy is the most common neurologic complication, but focal CNS involvement can sometimes be the initial presentation. We report a case of a woman infected with Legionella pneumophila presenting with vague symptomatology and focal neurologic findings...
September 2016: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/27788254/microorganisms-causing-community-acquired-acute-bronchitis-the-role-of-bacterial-infection
#15
Ji Young Park, Sunghoon Park, Sun Hwa Lee, Myung Goo Lee, Yong Bum Park, Kil Chan Oh, Jae-Myung Lee, Do Il Kim, Ki-Hyun Seo, Kyeong-Cheol Shin, Kwang Ha Yoo, Yongchun Ko, Seung Hun Jang, Ki-Suck Jung, Yong Il Hwang
BACKGROUND: Although acute bronchitis is quite common, there is relatively limited information regarding the microorganisms that are involved in this illness. METHODS: We performed a prospective study of acute bronchitis at 31 hospitals and clinics in Korea from July 2011 to June 2012. Sputum specimens were collected for polymerase chain reaction (PCR) and culture of microorganisms. RESULTS: Of the 811 enrolled patients, 291 had acceptable sputum specimens that were included for analysis of the etiologic distribution...
2016: PloS One
https://www.readbyqxmd.com/read/27779835/legionellosis-in-poland-in-2014
#16
Hanna Stypułkowska-Misiurewicz, Michał Czerwiński
OBJECTIVE: The aim of the study was to assess the epidemiological situation of legionellosis in Poland in 2014. MATERIAL AND METHODS: We reviewed data published in the annual bulletin: “Infectious diseases and poisonings in Poland in 2014” and its prior versions along with the legionellosis case reports sent to the Department of Epidemiology of NIPH - NIH. RESULTS: In Poland, both two forms of legionellosis - Legionnaires’ disease (a severe form of disease accompanied by pneumonia) and Pontiac fever (mild, influenza-like form of infection) - are routinely reported to the surveillance...
2016: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/27773623/-increasing-incidence-of-community-acquired-pneumonia-caused-by-atypical-microorganisms
#17
M A Tazón-Varela, H Alonso-Valle, P Muñoz-Cacho, J Gallo-Terán, X Piris-García, L A Pérez-Mier
INTRODUCTION: Knowing the most common microorganisms in our environment can help us to make proper empirical treatment decisions. The aim is to identify those microorganisms causing community-acquired pneumonia. PATIENTS AND METHODS: An observational, descriptive and prospective study was conducted, including patients over 14 years with a clinical and radiographic diagnosis of community-acquired pneumonia during a 383 consecutive day period. A record was made of sociodemographic variables, personal history, prognostic severity scales, progress, and pathogenic agents...
October 20, 2016: Semergen
https://www.readbyqxmd.com/read/27766169/microbial-etiology-of-community-acquired-pneumonia-among-infants-and-children-admitted-to-the-pediatric-hospital-ain-shams-university
#18
Magda Yehia El Seify, Eman Mahmoud Fouda, Hanan Mohamed Ibrahim, Maha Muhammad Fathy, Asmaa Al Husseiny Ahmed, Walaa Shawky Khater, Noha Nagi Mohammed Salah El Deen, Heba Galal Mohamed Abouzeid, Nancy Riyad Ahmed Hegazy, Heba Salah Sayed Elbanna
BACKGROUND: While recognizing the etiology of community-acquired pneumonia is necessary for formulating local antimicrobial guidelines, limited data is published about this etiology in Egyptian pediatric patients. OBJECTIVES: To determine the frequency of bacterial and viral pathogens causing community-acquired pneumonia (CAP) among immunocompetent Egyptian infants and preschool children. METHODS: Ninety infants and preschool-age children admitted to our hospital with CAP were prospectively included in the study...
September 29, 2016: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/27753516/solithromycin-for-the-treatment-of-community-acquired-bacterial-pneumonia
#19
Diego Viasus, Oscar Ramos, Leidy Ramos, Antonella F Simonetti, Jordi Carratalà
Community-acquired pneumonia is a major public health problem worldwide. In recent years, there has been an increase in the frequency of resistance to the antimicrobials such as β-lactams or macrolides which have habitually been used against the causative pathogens. Solithromycin, a next-generation macrolide, is the first fluoroketolide with activity against most of the frequently isolated bacteria in community-acquired pneumonia, including typical and atypical bacteria as well as macrolide-resistant Streptococcus pneumoniae...
October 31, 2016: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/27747691/hypersensitivity-eosinophilic-myocarditis-in-a-patient-receiving-multiple-drug-therapy-challenges-in-diagnosis-and-defining-the-aetiology
#20
Dario Gulin, Jozica Sikic, Jasna Cerkez Habek, Sandra Jerkovic Gulin, Edvard Galic
Eosinophilic myocarditis (EM) is a rare and potentially fatal disease if left untreated. Because the disease can have a delayed presentation and can appear even after 2 years, its underlying causes often remain unknown. We report the case of a 63-year-old man with an atypical clinical presentation of hypersensitive EM and significant coronary artery disease, which was confirmed through coronary angiography. The patient was treated with hydrochlorothiazide (12.5 mg once daily for 2 years) and budesonide/formoterol (160/4...
December 2016: Drug Safety—Case Reports
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