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https://www.readbyqxmd.com/read/28431035/medical-symptom-validity-test-performance-following-moderate-severe-traumatic-brain-injury-expectations-based-on-orientation-log-classification
#1
Stephen N Macciocchi, Ronald T Seel, Angela Yi, Sarah Small
Objective: This study examined performance on the Medical Symptom Validity test (MSVT) during acute rehabilitation for moderate-severe traumatic brain injury (TBI) stratified by Orientation Log (O-Log) scores. Method: Participants were 77 prospectively enrolled persons who sustained moderate-severe TBI and were acutely hospitalized secondary to the cognitive, medical and physical sequelae of their TBI. Participants were administered neuropsychological metrics, the O-Log and the MSVT a mean of 44 days post injury...
May 1, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28430782/predictors-of-falls-and-mortality-among-elderly-adults-with-traumatic-brain-injury-a-nationwide-population-based-study
#2
Wayne W Fu, Terence S Fu, Rowan Jing, Steven R McFaull, Michael D Cusimano
BACKGROUND: Elderly adults are at particular risk of sustaining a traumatic brain injury (TBI), and tend to suffer worse outcomes compared to other age groups. Falls are the leading cause of TBI among the elderly. METHODS: We examined nationwide trends in TBI hospitalizations among elderly adults (ages 65 and older) between April 2006 and March 2011 using a population-based database that is mandatory for all hospitals in Canada. Trends in admission rates were analyzed using linear regression...
2017: PloS One
https://www.readbyqxmd.com/read/28429775/fucoxanthin-provides-neuroprotection-in-models-of-traumatic-brain-injury-via-the-nrf2-are-and-nrf2-autophagy-pathways
#3
Li Zhang, Handong Wang, Youwu Fan, Yongyue Gao, Xiang Li, Zhigang Hu, Ke Ding, Yujie Wang, Xiaoliang Wang
Fucoxanthin is abundant in seaweed and is considered as a powerful antioxidant. It has been proposed to possess anti-cancer, anti-obesity and anti-diabetes effects. However, its roles in brain injury models have not been fully understood. The objective of this study was to investigate the neuroprotection of fucoxanthin in models of traumatic brain injury (TBI) and the role of the nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant-response element (ARE) and Nrf2-autophagy pathways in the putative neuroprotection...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28429734/neuroprotective-pentapeptide-cn-105-is-associated-with-reduced-sterile-inflammation-and-improved-functional-outcomes-in-a-traumatic-brain-injury-murine-model
#4
Daniel T Laskowitz, Haichen Wang, Tony Chen, David T Lubkin, Viviana Cantillana, Tian Ming Tu, Dawn Kernagis, Guanen Zhou, Gary Macy, Bradley J Kolls, Hana N Dawson
At present, there are no proven pharmacological treatments demonstrated to improve long term functional outcomes following traumatic brain injury(TBI). In the setting of non-penetrating TBI, sterile brain inflammatory responses are associated with the development of cerebral edema, intracranial hypertension, and secondary neuronal injury. There is increasing evidence that endogenous apolipoprotein E(apoE) modifies the neuroinflammatory response through its role in downregulating glial activation, however, the intact apoE holoprotein does not cross the blood-brain barrier due to its size...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28429381/the-structural-connectome-of-children-with-traumatic-brain-injury
#5
Marsh Königs, L W Ernest van Heurn, Roel Bakx, R Jeroen Vermeulen, J Carel Goslings, Bwee Tien Poll-The, Marleen van der Wees, Coriene E Catsman-Berrevoets, Jaap Oosterlaan, Petra J W Pouwels
This study aimed to investigate the impact of mild to severe pediatric TBI on the structural connectome. Children aged 8-14 years with trauma control (TC) injury (n = 27) were compared to children with mild TBI and risk factors for complicated TBI (mild(RF+) , n = 20) or moderate/severe TBI (n = 16) at 2.8 years post-injury. Probabilistic tractography on diffusion tensor imaging data was used in combination with graph theory to study structural connectivity. Functional outcome was measured using neurocognitive tests and parent and teacher questionnaires for behavioral functioning...
April 21, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28429354/the-role-of-the-hippocampus-and-the-function-of-calcitonin-gene-related-peptide-in-the-mechanism-of-traumatic-brain-injury-accelerating-fracture-healing
#6
Y Song, G-X Han, L Chen, Y-Z Zhai, J Dong, W Chen, T-S Li, H-Y Zhu
OBJECTIVE: This research attempts to identify the part the hippocampus plays in accelerated fracture-healing after traumatic brain injury as well as to test functions of calcitonin gene-related peptide (CGRP) during this process. MATERIALS AND METHODS: Experiments were carried out on Male Sprague-Dawley rats that were split into four groups at random: TBI-fracture group, fracture-only group, TBI-only group, and control group. In the first week, blood specimen would be drawn from rats among the groups except those of the control group at three-time points (24, 72 and 168 hours) post-damage...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429236/the-course-of-headache-in-patients-with-moderate-to-severe-headache-due-to-mild-traumatic-brain-injury-a-retrospective-cross-sectional-study
#7
Chang-Ki Hong, Jin-Yang Joo, Yu Shik Shim, Sook Young Sim, Min A Kwon, Yong Bae Kim, Joonho Chung
BACKGROUND: Little is known about the long-term course of headache in patients with moderate-to-severe headache due to traumatic brain injury (TBI). We evaluated the course of headache in patients with moderate-to-severe headache due to mild TBI. METHODS: Since September 2009, patients with TBI prospectively rated their headache using a numeric rating scale (NRS). From the database containing 935 patients with TBI between September 2009 and December 2013, 259 patients were included according to following criteria: (1) newly onset moderate-to-severe headache (NRS ≥ 4) due to head trauma; (2) age ≥ 15 years; (3) Glasgow Coma Scale ≥ 13; (4) transient loss of consciousness ≤ 30 min; and (5) radiographic evaluation, such as computed tomography or magnetic resonance image...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28426378/ostracism-and-physiological-arousal-following-traumatic-brain-injury
#8
Michelle Kelly, Skye McDonald, Jacqueline Rushby
PRIMARY OBJECTIVE: This study aimed to examine the psychological and physiological effects of ostracism in adults with traumatic brain injury (TBI). RESEARCH DESIGN: A within-subject, counterbalanced design was used. The two conditions, inclusion and ostracism, were examined across two groups (between subjects). METHODS AND PROCEDURES: A group of 21 adults with TBI and 17 matched controls participated in the Cyberball paradigm. This task is a computerised task that exposes participants to a game of catch and throw...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28426348/traumatic-brain-injury-and-lifetime-suicidality-applying-the-interpersonal-psychological-theory-perspective
#9
Claire N Bryson, Robert J Cramer, Adam T Schmidt
The present paper investigates the traumatic brain injury (TBI)-suicide link, assessing whether: (a) TBI accounts for variance in suicide risk, and (b) The Interpersonal-Psychological Theory of Suicide can be applied to TBI status. Matched case-control procedures applied to archival college student health data identified TBI and non-TBI subsamples (84 total). Individuals with a TBI possessed higher suicide risk than those without. Even accounting for the relative influence of strong suicide risk factors (i...
April 20, 2017: Death Studies
https://www.readbyqxmd.com/read/28425334/remifentanil-for-sedation-of-children-with-traumatic-brain-injury
#10
James L Hungerford, Nicole O'Brien, Melissa Moore-Clingenpeel, Eric A Sribnick, Cheryl Sargel, Mark Hall, Jeffrey R Leonard, Joseph D Tobias
OBJECTIVE: To determine whether remifentanil would provide adequate sedation while allowing frequent and reproducible neurologic assessments in children admitted to the pediatric intensive care unit (PICU) with traumatic brain injury (TBI) during mechanical ventilation. DESIGN: Retrospective review. SETTING: Tertiary care PICU. PATIENTS: Thirty-eight patients over a 30-month period. MEASUREMENTS AND MAIN RESULTS: Median age was 9 years (interquartile range [IQR] 2...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28424745/distinguishing-the-unique-neuropathological-profile-of-blast-polytrauma
#11
W Brad Hubbard, Shaylen Greenberg, Carly Norris, Joseph Eck, Erin Lavik, Pamela VandeVord
Traumatic brain injury sustained after blast exposure (blast-induced TBI) has recently been documented as a growing issue for military personnel. Incidence of injury to organs such as the lungs has decreased, though current epidemiology still causes a great public health burden. In addition, unprotected civilians sustain primary blast lung injury (PBLI) at alarming rates. Often, mild-to-moderate cases of PBLI are survivable with medical intervention, which creates a growing population of survivors of blast-induced polytrauma (BPT) with symptoms from blast-induced mild TBI (mTBI)...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28424597/working-memory-after-traumatic-brain-injury-the-neural-basis-of-improved-performance-with-methylphenidate
#12
Anne E Manktelow, David K Menon, Barbara J Sahakian, Emmanuel A Stamatakis
Traumatic brain injury (TBI) often results in cognitive impairments for patients. The aim of this proof of concept study was to establish the nature of abnormalities, in terms of activity and connectivity, in the working memory network of TBI patients and how these relate to compromised behavioral outcomes. Further, this study examined the neural correlates of working memory improvement following the administration of methylphenidate. We report behavioral, functional and structural MRI data from a group of 15 Healthy Controls (HC) and a group of 15 TBI patients, acquired during the execution of the N-back task...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28423999/toe-brachial-index-measured-by-automated-device-compared-to-duplex-ultrasonography-for-detecting-peripheral-arterial-disease-in-older-people
#13
Jennifer Sonter, Peta Tehan, Vivienne Chuter
Introduction To investigate the diagnostic accuracy of an automated toe blood pressure device for detecting peripheral arterial disease in older people. Methods Ninety participants underwent toe and brachial blood pressure measurements and colour duplex ultrasonography of the right lower limb. Peripheral arterial disease was diagnosed if > 50% arterial obstruction was identified in any lower limb vessel using colour duplex ultrasonography. A receiver operating characteristic curve was analysed and the sensitivity and specificity of commonly used toe brachial index and toe blood pressure values were determined...
January 1, 2017: Vascular
https://www.readbyqxmd.com/read/28422992/the-evolution-of-cost-efficiency-in-neural-networks-during-recovery-from-traumatic-brain-injury
#14
Arnab Roy, Rachel A Bernier, Jianli Wang, Monica Benson, Jerry J French, David C Good, Frank G Hillary
A somewhat perplexing finding in the systems neuroscience has been the observation that physical injury to neural systems may result in enhanced functional connectivity (i.e., hyperconnectivity) relative to the typical network response. The consequences of local or global enhancement of functional connectivity remain uncertain and this is particularly true for the overall metabolic cost of the network. We examine the hyperconnectivity hypothesis in a sample of 14 individuals with TBI with data collected at approximately 3, 6, and 12 months following moderate and severe TBI...
2017: PloS One
https://www.readbyqxmd.com/read/28422901/the-deployment-trauma-phenotype-and-employment-status-in-veterans-of-the-wars-in-iraq-and-afghanistan
#15
Melissa M Amick, Mark Meterko, Catherine B Fortier, Jennifer R Fonda, William P Milberg, Regina E McGlinchey
OBJECTIVES: To determine the prevalence of comorbid mild traumatic brain injury (mTBI), posttraumatic stress disorder (PTSD), and depression, termed the deployment trauma phenotype (DTP), and its constituent diagnoses' impact on unemployment status in a national cohort of veterans. SETTING: Retrospective analysis of the comprehensive TBI evaluation, a Veterans Affairs-wide protocol for assessing TBI, employment status, and psychiatric impressions. PARTICIPANTS: The final data set consisted of 48 821 veterans...
April 18, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28422900/the-association-between-posttraumatic-stress-disorder-and-perceptions-of-deployment-related-injury-in-veterans-with-and-without-mild-traumatic-brain-injury
#16
Nazanin H Bahraini, Lindsey L Monteith, Holly R Gerber, Jeri E Forster, Trisha A Hostetter, Lisa A Brenner
OBJECTIVES: To examine whether the association between posttraumatic stress disorder (PTSD) and injury perceptions (ie, consequences, emotional representations, and coherence) differs for Veterans with mild traumatic brain injury (mTBI) compared with Veterans with non-TBI (ie, orthopedic). PARTICIPANTS: Eighty Veterans injured during post-9/11 deployments. DESIGN: Observational, 2×2 factorial design. MAIN MEASURES: Injury histories ascertained using the Ohio State University TBI-Identification Method and Deployment Injury Questionnaire; Injury Perception Questionnaire-Revised (injury perceptions); Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (PTSD diagnosis); and PTSD Symptom Checklist-Civilian Version (PTSD symptoms)...
April 18, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28422899/variation-in-adult-traumatic-brain-injury-outcomes-in-the-united-states
#17
Nathaniel H Greene, Mary A Kernic, Monica S Vavilala, Frederick P Rivara
OBJECTIVE: To ascertain the degree of variation, by state of acute care hospitalization, in outcomes associated with traumatic brain injury (TBI) in an adult population. SETTING: All acute care hospitals in 21 states in the United States in the year 2010. PARTICIPANTS: Adult (> 18 years) patients (N = 95 546) admitted to a hospital with a moderate or severe TBI. DESIGN: Retrospective cohort study using data from State Inpatient Databases from Agency for Healthcare Research and Quality's Healthcare Cost and Utilization Project...
April 18, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28422898/internet-and-social-media-use-after-traumatic-brain-injury-a-traumatic-brain-injury-model-systems-study
#18
Christina Baker-Sparr, Tessa Hart, Thomas Bergquist, Jennifer Bogner, Laura Dreer, Shannon Juengst, David Mellick, Therese M OʼNeil-Pirozzi, Angelle M Sander, Gale G Whiteneck
OBJECTIVES: To characterize Internet and social media use among adults with moderate to severe traumatic brain injury (TBI) and to compare demographic and socioeconomic factors associated with Internet use between those with and without TBI. SETTING: Ten Traumatic Brain Injury Model Systems centers. PARTICIPANTS: Persons with moderate to severe TBI (N = 337) enrolled in the TBI Model Systems National Database and eligible for follow-up from April 1, 2014, to March 31, 2015...
April 18, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28422897/outcomes-associated-with-blast-versus-nonblast-related-traumatic-brain-injury-in-us-military-service-members-and-veterans-a-systematic-review
#19
Nancy Greer, Nina Sayer, Eva Koeller, Tina Velasquez, Timothy J Wilt
OBJECTIVES: To systematically review the literature on comparative clinical and functional outcomes following blast-related versus nonblast-related traumatic brain injury (TBI) among US service members and Veterans. DESIGN: MEDLINE search (January 2001 to June 2016) supplemented with hand search of reference lists and input from peer reviewers. RESULTS: Thirty-one studies (in 33 articles) reported on health outcomes; only 2 were rated low risk of bias...
April 18, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28422643/occupational-therapy-interventions-for-adults-with-traumatic-brain-injury
#20
Steven Wheeler, Amanda Acord-Vira, Marian Arbesman, Deborah Lieberman
This Evidence Connection describes a case report of an adult with traumatic brain injury (TBI), applying the evidence for intervention from the systematic reviews on TBI that were conducted in conjunction with the American Occupational Therapy Association's (AOTA's) Evidence-Based Practice Project. The occupational therapy assessment and treatment processes for hospital, home, and community settings are described. Evidence Connection articles provide a clinical application of systematic reviews developed in conjunction with AOTA's Evidence-Based Practice Project...
May 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
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