keyword
https://read.qxmd.com/read/38498064/the-combination-treatment-of-hypothermia-and-intranasal-insulin-ameliorates-the-structural-and-functional-changes-in-a-rat-model-of-traumatic-brain-injury
#1
JOURNAL ARTICLE
Hadi Moatamed Jahromi, Ali Rafati, Saied Karbalay-Doust, Somaye Keshavarz, Maryam Naseh
The present study aimed to investigate the combination effects of hypothermia (HT) and intranasal insulin (INS) on structural changes of the hippocampus and cognitive impairments in the traumatic brain injury (TBI) rat model. The rats were divided randomly into the following five groups (n = 10): Sham, TBI, TBI with HT treatment for 3 h (TBI + HT), TBI with INS (ten microliters of insulin) treatment daily for 7 days (TBI + INS), and TBI with combining HT and INS (TBI + HT + INS)...
March 18, 2024: Brain Structure & Function
https://read.qxmd.com/read/38497992/video-laryngoscopy-vs-direct-laryngoscopy-for-endotracheal-intubation-in-the-operating-room-a-cluster-randomized-clinical-trial
#2
JOURNAL ARTICLE
Kurt Ruetzler, Sergio Bustamante, Marc T Schmidt, Federico Almonacid-Cardenas, Andra Duncan, Andrew Bauer, Alparslan Turan, Nikolaos J Skubas, Daniel I Sessler
IMPORTANCE: Endotracheal tubes are typically inserted in the operating room using direct laryngoscopy. Video laryngoscopy has been reported to improve airway visualization; however, whether improved visualization reduces intubation attempts in surgical patients is unclear. OBJECTIVE: To determine whether the number of intubation attempts per surgical procedure is lower when initial laryngoscopy is performed using video laryngoscopy or direct laryngoscopy. DESIGN, SETTING, AND PARTICIPANTS: Cluster randomized multiple crossover clinical trial conducted at a single US academic hospital...
March 18, 2024: JAMA
https://read.qxmd.com/read/38497924/comparison-of-the-efficacy-and-safety-of-sodium-valproate-versus-levetiracetam-in-the-treatment-of-severe-traumatic-brain-injury
#3
JOURNAL ARTICLE
Xiaolei Huang, Wenjia Lin, Jiayin Wang, Chubin Liu, Guan Wei, Jiawei Wang, Chaoyang Wang
Objective: To observe the efficacy and safety of sodium valproate (VPA) compared to levetiracetam (LEV) in the treatment of severe traumatic brain injury (sTBI). Methods: In this blind, prospective study, eighty-four sTBI patients who had craniotomy from August 2021 to August 2023 were randomly split into two groups through random number table method: LEV and VPA, each with 42 patients. Both received comprehensive treatment post-craniotomy. LEV group: LEV injection on surgery day, transitioning to LEV tablets from day two...
March 18, 2024: International Journal of Neuroscience
https://read.qxmd.com/read/38497766/shaking-up-our-approach-the-need-for-characterization-and-optimization-of-preclinical-models-of-infant-abusive-head-trauma
#4
JOURNAL ARTICLE
Sydney Harris, Holly Chinnery, Bridgette D Semple, Richelle Mychasiuk
Traumatic brain injuries are a large societal and individual burden. In the first year of life, the vast majority of these injuries are the result of inflicted abusive events by a trusted caregiver. Abusive head trauma (AHT) in infants, formerly known as shaken baby syndrome, is the leading cause of inflicted mortality and morbidity in this population. In this review we address clinical diagnosis, symptoms, prognosis, and neuropathology of AHT, emphasizing the burden of repetitive AHT. Next, we consider existing animal models of AHT, and evaluate key features of an ideal model, highlighting important developmental milestones in children most vulnerable to AHT...
March 18, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38497747/characteristics-and-neural-mechanisms-of-sleep-wake-disturbances-after-traumatic-brain-injury
#5
JOURNAL ARTICLE
Guizhong Yan, Yuan Wei, Dengfeng Wang, Dong Wang, Haijun Ren, Boru Hou
Sleep-wake disturbances (SWDs) is one of the most common complaints following traumatic brain injury (TBI). The high prevalence and socioeconomic burden of sleep-wake disturbances (SWDs) post-TBI have only been recognized in the past decade. Common SWDs induced by TBI include excessive daytime sleepiness (EDS), hypersomnia, insomnia, obstructive sleep apnea (OSA), and circadian rhythm sleep disorders. Sleep disturbances can significantly compromise quality of life, strain interpersonal relationships, diminish work productivity, exacerbate other clinical conditions, and impede the rehabilitation process of TBI patients...
March 18, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38497739/visual-impairment-in-preclinical-models-of-mild-traumatic-brain-injury
#6
JOURNAL ARTICLE
Gabriella Orbach, Eva Melendes, Kaitlyn Warren, Jianhua Qiu, William Meehan, Rebekah Mannix, Fernanda Guilhaume Correa
Impairment in visual function is common after traumatic brain injury (TBI) in the clinical setting, a phenomenon that translates to pre-clinical animal models as well. Our laboratory's previous work has reported histological changes following weight-drop induced TBI in a rodent model including retinal ganglion cell (RGC) loss, decreased electroretinogram (ERG) evoked potential, optic nerve diameter reduction, induced inflammation and gliosis, and loss of myelin accompanied by markedly impaired visual acuity...
March 18, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38497612/fatal-vertebral-artery-dissection-following-self-manipulation-of-the-cervical-spine
#7
JOURNAL ARTICLE
Jane E Persons, Stephanie Stauffer
Cervical spine manipulation is a known risk factor for vertebral artery dissection. In this report, we present a case of fatal vertebral artery dissection that occurred as the result of self-manipulation of the cervical spine. The decedent was a 40-year-old man with no significant past medical history. He was observed to "crack his neck" while at work. Soon after, he began experiencing neck pain, then developed strokelike symptoms and became unresponsive. He was transported to a local medical center, where imaging showed bilateral vertebral artery dissection...
March 18, 2024: American Journal of Forensic Medicine and Pathology
https://read.qxmd.com/read/38497571/valued-living-after-mild-traumatic-brain-injury-characteristics-and-relationship-with-outcomes
#8
JOURNAL ARTICLE
Josh W Faulkner, Diane Whiting, Alice Theadom, Deborah L Snell, Maree Roche, Suzanne Barker-Collo
Psychological factors are strong predictors of mild traumatic brain injury (mTBI) recovery, consequently, psychological interventions can form part of an individual's rehabilitation. This may include enhancing valued living (VL), an approach that is effective in severe and mixed acquired brain injury samples. This study aimed to characterize VL in mTBI and explore its relationship with mTBI and mental health outcomes. 56 participants with a mTBI completed self-report measures before engaging in a psychological intervention...
March 18, 2024: Neuropsychological Rehabilitation
https://read.qxmd.com/read/38497232/confounding-factors-impacting-the-glasgow-coma-score-a-literature-review
#9
REVIEW
Kaveh Barami
BACKGROUND: The Glasgow coma score (GCS) is a clinical tool used to measure level of consciousness in traumatic brain injury and other settings. Despite its widespread use, there are many inaccuracies in its reporting. One source of inaccuracy is confounding factors which affect consciousness as well as each sub-score of the GCS. The purpose of this article was to create a comprehensive list of confounding factors in order to improve the accuracy of the GCS and ultimately improve decision-making...
March 18, 2024: Neurological Research
https://read.qxmd.com/read/38497194/assessing-the-effectiveness-and-safety-of-transbronchial-lung-cryobiopsy-utilizing-a-flexible-bronchoscope-with-an-endobronchial-blocker-in-diffuse-parenchymal-lung-lesions
#10
JOURNAL ARTICLE
Deepak Sharma, Vinay V, Jitendra Kumar Saini, Prabhpreet Sethi, Lokender Kumar, Praveen Kumar Dubey
Transbronchial lung cryobiopsy (TBLC) with flexible bronchoscope represents an encouraging modality to obtain a larger size specimen without crush artifact, and a higher diagnostic yield in patients with diffuse parenchymal lung lesions/diseases as compared to conventional transbronchial lung biopsy, and fewer complications as opposed to surgical lung biopsy. Artificial airway is preferred as it provides better airway protection in cases of severe bleeding. Although various researchers have published data on different modalities, the data is not sufficient to standardize a single technique...
March 15, 2024: Monaldi Archives for Chest Disease
https://read.qxmd.com/read/38497188/effects-of-transcranial-direct-current-stimulation-on-motor-and-cognitive-dysfunction-in-an-experimental-traumatic-brain-injury-model
#11
JOURNAL ARTICLE
Guven Akcay, Filiz Demirdogen, Tuba Gul, Ali Yilmaz, Dilcan Kotan, Esra Karakoc, Huseyin Emre Ozturk, Cagla Celik, Haydar Celik, Yavuz Erdem
AIM: To investigate the therapeutic and neuroprotective effects of transcranial direct current stimulation (tDCS) application on the traumatic brain injury (TBI)-induced glutamate and calcium excitotoxicity and loss of motor and cognitive functions. MATERIAL AND METHODS: Forty rats were equally divided in the sham, TBI, tDCS + TBI + tDCS, and TBI + tDCS groups. Mild TBI was induced by dropping a 450-g iron weight from a height of 1 m onto the skull of the rats. The tDCS + TBI + tDCS group was prophylactically administered 1 mA stimulation for 30 min for 7 days starting 5 days before inducing TBI...
2024: Turkish Neurosurgery
https://read.qxmd.com/read/38497179/the-effects-of-regulating-increased-blood-glucose-levels-on-plasma-endothelin-1-levels-after-severe-head-trauma-in-rats
#12
JOURNAL ARTICLE
Mehmet Meral, Rahmi Kemal Koc, Ahmet Selcuklu
AIM: To examine the effects of regulating increased blood glucose levels on plasma ET-1 levels after severe head trauma in rats. MATERIAL AND METHODS: Traumatic diffuse brain injury-induced rats were followed for 7 days and were randomly divided into two groups of 36 rats. Pre- and posttraumatic blood glucose and ET-1 levels were measured in group 1 (control). Posttraumatic blood glucose levels were maintained at normal levels using insulin and both blood glucose and ET-1 levels were measured at 2, 6, 12, 24, and 48 h and 7 days posttrauma in group 2...
2024: Turkish Neurosurgery
https://read.qxmd.com/read/38497117/executive-functioning-behavior-and-white-matter-microstructure-in-the-chronic-phase-after-pediatric-mild-traumatic-brain-injury-results-from-the-adolescent-brain-cognitive-development-study
#13
JOURNAL ARTICLE
Anja K Betz, Suheyla Cetin-Karayumak, Elena M Bonke, Johanna Seitz-Holland, Fan Zhang, Steve Pieper, Lauren J O'Donnell, Yorghos Tripodis, Yogesh Rathi, Martha E Shenton, Inga K Koerte
BACKGROUND: Mild traumatic brain injury (mTBI) is common in children. Long-term cognitive and behavioral outcomes as well as underlying structural brain alterations following pediatric mTBI have yet to be determined. In addition, the effect of age-at-injury on long-term outcomes is largely unknown. METHODS: Children with a history of mTBI ( n = 406; M age = 10 years, SD age = 0.63 years) who participated in the Adolescent Brain Cognitive Development (ABCD) study were matched (1:2 ratio) with typically developing children (TDC; n = 812) and orthopedic injury (OI) controls ( n = 812)...
March 18, 2024: Psychological Medicine
https://read.qxmd.com/read/38497037/a-scoping-review-on-muscle-cramps-and-spasms-in-upper-motor-neuron-disorder-two-sides-of-the-same-coin
#14
REVIEW
Eva Rudjord Therkildsen, Pernille Kaster, Jens Bo Nielsen
BACKGROUND: Muscle cramps are typically regarded as benign muscle overactivity in healthy individuals, whereas spasms are linked to spasticity resulting from central motor lesions. However, their striking similarities made us hypothesize that cramping is an under-recognized and potentially misidentified aspect of spasticity. METHODS: A systematic search on spasms and cramps in patients with Upper Motor Neuron Disorder (spinal cord injury, cerebral palsy, traumatic brain injury, and stroke) was carried out in Embase/Medline, aiming to describe the definitions, characteristics, and measures of spasms and cramps that are used in the scientific literature...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38496779/prevalence-of-dual-sensory-impairment-in-veterans-a-rapid-systematic-review
#15
REVIEW
Zara Raza, Syeda F Hussain, Renata S M Gomes
Dual sensory impairment (DSI) is prevalent in the older population, but due to exposure to military-related risk factors, it is a particular problem for veterans, older and younger. This rapid review aimed to critically review and summarise the prevalence of DSI in military veteran populations, as well as any associative factors and outcomes that were assessed. This was done in accordance with the Preferred Reporting Items for Systematic Reviews (PRISMA) statement. Several databases (Scopus, Web of Science, AMED, CINAHL Plus, Ultimate, and MEDLINE via EBSCOHost) were searched and five studies were selected for final review...
2024: Front Rehabil Sci
https://read.qxmd.com/read/38496110/comparison-of-opioid-based-versus-opioid-sparing-anesthesia-in-patients-undergoing-glioma-surgery
#16
JOURNAL ARTICLE
Anupama A S, Ashutosh Kaushal, Vaishali Waindeskar, Saurabh Saigal, Anuj Jain, Harish Kumar, Pranita Mandal, Sandeep Kumar, Sweta Kumari, Anjan K Sahoo
Background In the neurosurgical population, opioids may cause respiratory depression, leading to hypercapnia, increased cerebral blood flow (CBF), and ultimately increased intracranial pressure (ICP), which can mask early signs of intracranial complications and delayed emergence. This study was designed to compare perioperative hemodynamic stability, analgesia, and recovery parameters in opioid-based (fentanyl) general anesthesia versus opioid-sparing (dexmedetomidine) general anesthesia in patients undergoing glioma surgeries...
February 2024: Curēus
https://read.qxmd.com/read/38496079/dysphagia-secondary-to-myotonic-dystrophy-unveiled-in-a-case-of-destructive-spondylitis-with-synovitis-acne-pustulosis-hyperostosis-osteitis-sapho-syndrome-presenting-as-torticollis
#17
Yoshinori Ishikawa, Takashi Kobayashi, Ryo Shoji, Naohisa Miyakoshi
To report an instructive case involving destructive spondylitis and synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome, presenting with torticollis and postoperative dysphagia without hoarseness, attributed to hidden myotonic dystrophy (DM). A 51-year-old male patient with a cervical deformity, who was previously managed conservatively for a metastatic tumor, underwent reconstruction surgery and subsequently experienced postoperative dysphagia. The presence of destructive spondylitis with torticollis, warranting prompt assessment to prevent paralysis, adds complexity to the delayed identification of DM...
February 2024: Curēus
https://read.qxmd.com/read/38495962/cerebral-infarction-due-to-post-traumatic-cerebral-vasospasm-in-a-12-year-old-female
#18
Daisuke Tanikawa, Yushiro Take, Nobuaki Naito, Akio Teranishi, Hiroki Kurita
Cerebral infarction due to post-traumatic cerebral vasospasm is rare. Although some modalities are recommended to detect post-traumatic cerebral vasospasm, its diagnosis remains controversial and challenging. Therefore, in this report, we will use a case report to highlight challenges and to delineate the characteristics of post-traumatic cerebral vasospasm in pediatric patients, including the diagnostic and treatment options. A 12-year-old female was admitted to our hospital following a motor vehicle collision...
March 2024: Curēus
https://read.qxmd.com/read/38495522/propofol-sedation-does-not-improve-measures-of-colonoscopy-quality-but-increase-cost-findings-from-a-large-population-based-cohort-study
#19
JOURNAL ARTICLE
Sheikh Rahman, Lauren E Cipriano, Cassandra McDonald, Sarah Cocco, Ziad Hindi, Debarati Chakraborty, Karissa French, Omar Siddiqi, Mayur Brahmania, Aze Wilson, Brian Yan, Leonardo Guizzetti, Vipul Jairath, Michael Sey
BACKGROUND: Propofol is often used for sedation during colonoscopy. We assessed the impact of propofol sedation on colonoscopy related quality metrics and cost in a population-based cohort study. METHODS: All colonoscopies performed at 21 hospitals in the province of Ontario, Canada, during an 18-month period, from April 1, 2017 to October 31, 2018, using either propofol or conscious sedation were evaluated. The primary outcome was adenoma detection rate (ADR) and secondary outcomes were sessile serrated polyp detection rate (ssPDR), polyp detection rate (PDR), cecal intubation rate (CIR), and perforation rate...
April 2024: EClinicalMedicine
https://read.qxmd.com/read/38495421/editorial-current-trends-on-emotional-processing-contributions-of-acquired-brain-injury-neurodegenerative-diseases-and-ageing
#20
EDITORIAL
Beatriz García-Rodríguez, Álvaro Ruiz-García, Carolina Peña-Martínez
No abstract text is available yet for this article.
2024: Frontiers in Psychology
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