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https://www.readbyqxmd.com/read/29054447/deletion-ofmst1-attenuates-neuronal-loss-andimproves-neurological-impairment-inarat-model-oftraumatic-brain-injury
#1
Di Li, Haibo Ni, Qin Rui, Rong Gao, Gang Chen
Neuronal cell death following traumatic brain injury (TBI) is a considerable contributor to neurological deficits. In our work, we explored the functions of Mammalian STE20-like kinase-1 (Mst1), a apoptosis-promoting kinase and aslo a pivotal bridgebuilder of apoptotic signaling, in the etiopathogenesis of an experimental rat model of TBI. We found that the phosphorylation level of Mst1 in injured area was significantly increased after TBI. Furthermore, we discovered that inhibition of Mst1 phosphorylation can effectively reduce neuronal cell death by inhibiting the activation of caspase 3 and suppressing the damage of DNA during TBI...
October 17, 2017: Brain Research
https://www.readbyqxmd.com/read/29054135/alterations-in-the-timing-of-huperzine-a-cerebral-pharmacodynamics-in-the-acute-traumatic-brain-injury-setting
#2
Ugur Damar, Roman Gersner, Joshua T Johstone, Kush Kapur, Stephen D Collins, Steven Schachter, Alexander Rotenberg
Traumatic brain injury (TBI) may affect the pharmacodynamics of centrally acting drugs. Paired-pulse transcranial magnetic stimulation (ppTMS) is a safe and noninvasive measure of cortical GABA-mediated cortical inhibition. Huperzine A (HupA) is a naturally-occurring acetylcholinesterase inhibitor with newly discovered potent GABA-mediated antiepileptic capacity, which is reliably detected by ppTMS. To test whether TBI alters cerebral HupA pharmacodynamics, we exposed rats to fluid percussion injury (FPI), and tested whether ppTMS metrics of cortical inhibition differ in magnitude and temporal pattern in injured rats...
October 20, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29053925/mesenchymal-stem-cell-secretome-improves-tendon-cell-viability-in-vitro-and-tendon-bone-healing-in-vivo-when-a-tissue-engineering-strategy-is-used-in-a-rat-model-of-chronic-massive-rotator-cuff-tear
#3
Nuno Sevivas, Fábio Gabriel Teixeira, Raquel Portugal, Bruno Direito-Santos, João Espregueira-Mendes, Filipe J Oliveira, Rui F Silva, Nuno Sousa, Wan Ting Sow, Nguyen Luong, Kee Woei Ng, António J Salgado
BACKGROUND: Massive rotator cuff tears (MRCTs) represent a major clinical concern, especially when degeneration and chronicity are involved, which highly compromise healing capacity. PURPOSE: To study the effect of the secretome of mesenchymal stem cells (MSCs) on tendon cells (TCs) followed by the combination of these activated TCs with an electrospun keratin-based scaffold to develop a tissue engineering strategy to improve tendon-bone interface (TBi) healing in a chronic MRCT rat model...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29052464/longitudinal-study-of-objective-and-subjective-cognitive-performance-and-psychological-distress-in-oef-oif-veterans-with-and-without-traumatic-brain-injury
#4
Kerry Donnelly, James P Donnelly, Gary C Warner, C James Kittleson, Paul R King
OBJECTIVE: To describe changes in post-deployment objective and subjective cognitive performance in combat Veterans over 18 months, relative to traumatic brain injury (TBI) status and psychological distress. METHOD: This prospective cohort study examined 500 Veterans from Upstate New York at four time points, six months apart. TBI status was determined by a structured clinical interview. Neuropsychological instruments focused on attention, memory, and executive functions...
October 20, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/29051745/traumatic-brain-injury-severity-neuropathophysiology-and-clinical-outcome-insights-from-multimodal-neuroimaging
#5
Andrei Irimia, Sheng-Yang Matthew Goh, Adam C Wade, Kavi Patel, Paul M Vespa, John D Van Horn
BACKGROUND: The relationship between the acute clinical presentation of patients with traumatic brain injury (TBI), long-term changes in brain structure prompted by injury and chronic functional outcome is insufficiently understood. In this preliminary study, we investigate how acute Glasgow coma score (GCS) and epileptic seizure occurrence after TBIs are statistically related to functional outcome (as quantified using the Glasgow Outcome Score) and to the extent of cortical thinning observed 6 months after the traumatic event...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29050524/transcranial-doppler-systolic-flow-index-and-icp-derived-cerebrovascular-reactivity-indices-in-tbi
#6
Frederick Adam Zeiler, Danilo Cardim, Joseph Donnelly, David Menon, Marek Czosnyka, Peter Smieleweski
To explore relationships between transcranial Doppler (TCD) indices of cerebrovascular reactivity and those derived from intracranial pressure (ICP). GOALS: A. Confirm previously described co-variance patterns of TCD/ICP indices, and B. Describe thresholds for Sx (correlation between systolic flow velocity (FVs) and cerebral perfusion pressure (CPP)) associated with outcome. Retrospective cohort of traumatic brain injury (TBI) patients: with TCD and ICP monitoring, we calculated various continuous indices of cerebrovascular reactivity: A...
October 19, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29049053/treatment-options-for-posttraumatic-epilepsy
#7
Lara L Zimmermann, Ryan M Martin, Fady Girgis
PURPOSE OF REVIEW: Posttraumatic seizures (PTS) and posttraumatic epilepsy (PTE) are common and debilitating consequences of traumatic brain injury (TBI). Early PTS result in secondary brain injury by raising intracranial pressure and worsening cerebral edema and metabolic crisis. PTE is a localization-related epilepsy strongly associated with TBI severity, but risk factors for PTE and epileptogenesis are incompletely understood and are active areas of research. Medical management of PTS in adults and children is reviewed...
October 18, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29049003/-tau-immunotherapy-hopes-and-hindrances
#8
Koorosh Shahpasand, Alireza Sepehri Shamloo, Seyed Massood Nabavi, Xiao Zhen Zhou, Kun Ping Lu
Alzheimer's disease (AD) is a progressive neurological disorder having two major pathological hallmarks: the extracellular senile plaques and intracellular neurofibrillary tangles composed of amyloid beta protein and hyperphosphorylated tau respectively. Removal of protein deposits from AD brains are the newer attempts for treating AD. The major developments in this direction have been the amyloid and tau based therapeutics. While senile plaque removal employing monoclonal antibodies (mAbs) restore brain function in mouse models of AD, tau has been recently introduced as the major neurodegenerative factor mediating neural cell death...
October 19, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29046426/phosphorylation-of-connexin-43-induced-by-traumatic-brain-injury-promotes-exosome-release
#9
Wei Chen, Yijun Guo, Wenjin Yang, Lei Chen, Dabin Ren, Chenxing Wu, Bin He, Ping Zheng, Wusong Tong
Traumatic brain injury (TBI) caused by the external force leads to the neuronal dysfunction and even death. TBI has been reported to significantly increase the phosphorylation of glial gap junction protein connexin 43 (Cx43), which in turn propagates damages into surrounding brain tissues. However, the neuroprotective and anti-apoptosis effects of glia-derived exosomes have also been implicated in recent studies. Therefore, we detected whether TBI-induced phosphorylation of Cx43 would promote exosome release in rat brain...
October 18, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29043546/compensatory-reserve-weighted-intracranial-pressure-and-its-association-with-outcome-after-traumatic-brain-injury
#10
L Calviello, J Donnelly, D Cardim, C Robba, F A Zeiler, P Smielewski, M Czosnyka
OBJECTIVE: We introduced 'compensatory-reserve-weighted intracranial pressure (ICP),' named 'weightedICP' for brevity, as a variable that may better describe changes leading to mortality after traumatic brain injury (TBI) over the standard mean ICP. METHODS: ICP was monitored prospectively in over 1023 sedated and ventilated patients. The RAP coefficient (R-correlation, A-amplitude, and P-pressure) was calculated as the running correlation coefficient between slow changes in the pulse amplitude of ICP and the mean ICP...
October 17, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/29043082/effect-of-sex-and-age-on-traumatic-brain-injury-a-geographical-comparative-study
#11
Raaj Kishore Biswas, Enamul Kabir, Rachel King
BACKGROUND: Traumatic brain injury (TBI) is a much researched topic in medical health, which requires additional studies to understand various effects of demographic and geographic factors that can assist in developing the most effective treatments. Thousands of people of different ages are suffering from lifelong disabilities, either mild or severe, from TBI and the number is increasing. This study aims to increase our understanding of the effect of sex and age by applying five different statistical methods to evaluate the effect of these covariates on two independent TBI data sets representing patients from different geographical cohorts...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/29042562/cis-p-tau-is-induced-in-clinical-and-preclinical-brain-injury-and-contributes-to-post-injury-sequelae
#12
Onder Albayram, Asami Kondo, Rebekah Mannix, Colin Smith, Cheng-Yu Tsai, Chenyu Li, Megan K Herbert, Jianhua Qiu, Michael Monuteaux, Jane Driver, Sandra Yan, William Gormley, Ava M Puccio, David O Okonkwo, Brandon Lucke-Wold, Julian Bailes, William Meehan, Mark Zeidel, Kun Ping Lu, Xiao Zhen Zhou
Traumatic brain injury (TBI) is characterized by acute neurological dysfunction and associated with the development of chronic traumatic encephalopathy (CTE) and Alzheimer's disease. We previously showed that cis phosphorylated tau (cis P-tau), but not the trans form, contributes to tau pathology and functional impairment in an animal model of severe TBI. Here we found that in human samples obtained post TBI due to a variety of causes, cis P-tau is induced in cortical axons and cerebrospinal fluid and positively correlates with axonal injury and clinical outcome...
October 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29041954/combined-cognitive-and-vocational-interventions-after-mild-to-moderate-traumatic-brain-injury-study-protocol-for-a-randomized-controlled-trial
#13
Emilie I Howe, Knut-Petter S Langlo, Hans Christoffer Aargaard Terjesen, Cecilie Røe, Anne-Kristine Schanke, Helene L Søberg, Unni Sveen, Eline Aas, Heidi Enehaug, Daniele E Alves, Pål Klethagen, Kjersti Sagstad, Christine M Moen, Karin Torsteinsbrend, Anne-Margrethe Linnestad, Tonje Haug Nordenmark, Birte Sand Rismyhr, Grete Wangen, Juan Lu, Jennie Ponsford, Elizabeth W Twamley, Helene Ugelstad, Øystein Spjelkavik, Marianne Løvstad, Nada Andelic
BACKGROUND: A considerable proportion of patients with mild to moderate traumatic brain injury (TBI) experience long-lasting somatic, cognitive, and emotional symptoms that may hamper their capacity to return to work (RTW). Although several studies have described medical, psychological, and work-related factors that predict RTW after TBI, well-controlled intervention studies regarding RTW are scarce. Furthermore, there has traditionally been weak collaboration among health-related rehabilitation services, the labor and welfare sector, and workplaces...
October 17, 2017: Trials
https://www.readbyqxmd.com/read/29037020/factors-associated-with-pulmonary-toxicity-after-myeloablative-conditioning-using-fractionated-total-body-irradiation
#14
Hwa Kyung Byun, Hong In Yoon, Jaeho Cho, Hyun Ju Kim, Yoo Hong Min, Chuhl Joo Lyu, June-Won Cheong, Jin Seok Kim, Hyo Sun Kim, Soo-Jeong Kim, Andrew Jihoon Yang, Byung Min Lee, Won Hee Lee, Joongyo Lee, Ki Jung Ahn, Chang-Ok Suh
PURPOSE: Pulmonary toxicities, including infectious pneumonia (IP) and idiopathic pneumonia syndrome (IPS), are serious side effects of total body irradiation (TBI) used for myeloablative conditioning. This study aimed to evaluate clinical factors associated with IP and IPS following TBI. MATERIALS AND METHODS: Fifty-eight patients with hematologic malignancies who underwent TBI before allogeneic hematopoietic stem cell transplantation between 2005 and 2014 were reviewed...
September 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29036852/rehabilitation-modality-and-onset-differentially-influence-whisker-sensory-hypersensitivity-after-diffuse-traumatic-brain-injury-in-the-rat
#15
Theresa Currier Thomas, Ellen Magee Stockhausen, L Matthew Law, Aida Khodadad, Jonathan Lifshitz
BACKGROUND: As rehabilitation strategies advance as therapeutic interventions, the modality and onset of rehabilitation after traumatic brain injury (TBI) are critical to optimize treatment. Our laboratory has detected and characterized a late-onset, long-lasting sensory hypersensitivity to whisker stimulation in diffuse brain-injured rats; a deficit that is comparable to visual or auditory sensory hypersensitivity in humans with an acquired brain injury. OBJECTIVE: We hypothesize that the modality and onset of rehabilitation therapies will differentially influence sensory hypersensitivity in response to the Whisker Nuisance Task (WNT) as well as WNT-induced corticosterone (CORT) stress response in diffuse brain-injured rats and shams...
October 9, 2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29036680/factors-associated-with-opioid-initiation-in-oef-oif-ond-veterans-with-traumatic-brain-injury
#16
Teresa J Hudson, Jacob T Painter, Laura E Gressler, Liya Lu, J Silas Williams, Brenda M Booth, Bradley C Martin, Mark D Sullivan, Mark J Edlund
Objective: These analyses examined opioid initiation and chronic use among Iraq (OIF) and Afghanistan (OEF/OND) veterans with a new diagnosis of traumatic brain injury (TBI) in the Veterans Health Administration (VHA). Methods: Data were obtained from national VHA data repositories. Analyses included OEF/OIF/OND veterans with a new TBI diagnosis in 2010-2012 who used the VHA at least twice, had not received a VHA opioid prescription in the 365 days before diagnosis, and had at least 365 days of data available after TBI diagnosis...
September 26, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29035978/use-of-blood-biomarkers-in-the-assessment-of-sports-related-concussion-a-systematic-review-in-the-context-of-their-biological-significance
#17
Brendan OʼConnell, Áine M Kelly, David Mockler, Matej Orešič, Karl Denvir, Garreth Farrell, Damir Janigro, Fiona Wilson
OBJECTIVES: To critically review current knowledge on the positive and negative predictive value of blood biomarkers for concussion; to illustrate the clinical and biological contexts that help evaluate the use of these markers in sport-related traumatic brain injuries (TBIs). METHODS: This systematic review was performed in accordance with PRISMA guidelines. We reviewed the measurement, clinical utility, endpoint, and biological significance of blood biomarkers in concussion...
October 12, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29035459/level-of-platelet-distribution-width-and-outcome-prediction-in-patients-with-traumatic-brain-injury
#18
Biao Zhang, Jianjun Gu, Yizhen Qiu, Jin Zhao, Yi Song, Huojun Jiang, Aliang Ding, Xiaoqi Chen, Rongming Yu, Guofang Liu, Aihao Hu
BACKGROUND: This study examines the clinical utility of the level of increased platelet distribution width (PDW) as a predictor of outcome in patients with traumatic brain injury. METHODS: In this retrospective study, 120 patients with traumatic brain injury (TBI) were recruited. Age, gender, PDW, and Glasgow Coma Scale (GCS) scores were measured. These patients were divided into two groups based on their 30-day outcomes. Receiver operating curves (ROCs) were generated to identify predictors of 30-day mortality...
October 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29035067/executive-functioning-in-relation-to-coping-in-mild-versus-moderate-severe-traumatic-brain-injury
#19
Sandra E Rakers, Myrthe E Scheenen, Herma J Westerhof-Evers, Myrthe E de Koning, Harm J van der Horn, Joukje van der Naalt, Jacoba M Spikman
OBJECTIVE: To examine associations between executive functioning (EF) and coping styles, separately for mild and moderate-severe traumatic brain injury (TBI) in the chronic phase postinjury. METHOD: Patients with mild (n = 47) and moderate-severe TBI (n = 59) were included, in addition to healthy controls (HCs; n = 51). Assessment consisted of EF tests (Trail Making Test, Zoo Map Test, Controlled Oral Word Association Test) and questionnaires examining EF (Dysexecutive Questionnaire) and coping styles (Utrecht Coping List)...
October 16, 2017: Neuropsychology
https://www.readbyqxmd.com/read/29033888/concussion-as-a-multi-scale-complex-system-an-interdisciplinary-synthesis-of-current-knowledge
#20
REVIEW
Erin S Kenzie, Elle L Parks, Erin D Bigler, Miranda M Lim, James C Chesnutt, Wayne Wakeland
Traumatic brain injury (TBI) has been called "the most complicated disease of the most complex organ of the body" and is an increasingly high-profile public health issue. Many patients report long-term impairments following even "mild" injuries, but reliable criteria for diagnosis and prognosis are lacking. Every clinical trial for TBI treatment to date has failed to demonstrate reliable and safe improvement in outcomes, and the existing body of literature is insufficient to support the creation of a new classification system...
2017: Frontiers in Neurology
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