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https://www.readbyqxmd.com/read/29667129/elevation-of-mmp-9-levels-promotes-epileptogenesis-after-traumatic-brain-injury
#1
Barbara Pijet, Marzena Stefaniuk, Agnieszka Kostrzewska-Ksiezyk, Photini-Effie Tsilibary, Athina Tzinia, Leszek Kaczmarek
Posttraumatic epilepsy (PTE) is a recurrent seizure disorder that often develops secondary to traumatic brain injury (TBI) that is caused by an external mechanical force. Recent evidence shows that the brain extracellular matrix plays a major role in the remodeling of neuronal connections after injury. One of the proteases that is presumably responsible for this process is matrix metalloproteinase-9 (MMP-9). The levels of MMP-9 are elevated in rodent brain tissue and human blood samples after TBI. However, no studies have described the influence of MMP-9 on the development of PTE...
April 17, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29666199/does-magnesium-sulfate-have-a-role-in-the-management-of-severe-traumatic-brain-injury-in-civilian-and-military-populations-a-systematic-review-and-meta-analysis
#2
REVIEW
Marc W H Lyons, W J Blackshaw
INTRODUCTION: Traumatic brain injury (TBI) is a significant cause of combat morbidity. Currently, the medical management of TBI is limited to supportive critical care. Magnesium sulfate has been studied as a potentially beneficial therapeutic agent. METHODS: A systematic review and meta-analysis was undertaken, examining the role of magnesium in the management of severe TBI in adults. The primary outcome of the study was all-cause mortality, with secondary outcomes of Glasgow Outcome Score (GOS) and GCS...
April 17, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29665763/neuroimaging-radiological-interpretation-system-niris-for-acute-traumatic-brain-injury-tbi
#3
Max Wintermark, Ying Li, Victoria Y Ding, Yingding Xu, Bin Jiang, Robyn L Ball, Michael Zeineh, Alisa Gean, Pina Sanelli
To develop an outcome-based NeuroImaging Radiological Interpretation System (NIRIS) for acute traumatic brain injury (TBI) patients that would standardize the interpretation of non-contrast head CTs and consolidate imaging findings into ordinal severity categories that would inform specific patient management actions and that could be used as a clinical decision support tool. We retrospectively identified all patients transported to our emergency department by ambulance or helicopter, for whom a trauma alert was triggered per established criteria and who underwent a non-contrast head CT due to suspicion of TBI, between November 2015 and April 2016...
April 18, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29665077/gliovascular-changes-precede-white-matter-damage-and-long-term-disorders-in-juvenile-mild-closed-head-injury
#4
Beatriz Rodriguez-Grande, Andre Obenaus, Aleksandra Ichkova, Justine Aussudre, Thomas Bessy, Elodie Barse, Bassem Hiba, Gwénaëlle Catheline, Grégory Barrière, Jerome Badaut
Traumatic brain injury (TBI) is a leading cause of hospital visits in pediatric patients and often leads to long-term disorders even in cases of mild severity. White matter (WM) alterations are commonly observed in patients months or years after the injury assessed by magnetic resonance imaging (MRI), but little is known about WM pathophysiology early after mild pediatric TBI. To evaluate the status of the gliovascular unit in this context, mild TBI was induced in postnatal-day 17 mice using a closed head injury model with two grades of severity (G1, G2)...
April 17, 2018: Glia
https://www.readbyqxmd.com/read/29664836/teg-lysis-shutdown-represents-coagulopathy-in-bleeding-trauma-patients-analysis-of-the-proppr-cohort
#5
Jessica C Cardenas, Charles E Wade, Bryan A Cotton, Mitchell J George, John B Holcomb, Martin A Schreiber, Nathan J White
BACKGROUND: Thrombelastography (TEG) fibrinolysis shutdown after trauma is associated with increased mortality due to hypercoagulability-associated organ failure. However, a lack of mechanistic data has precluded the development of novel interventions to treat shutdown. OBJECTIVES: To define the pathophysiology of TEG shutdown in severely injured, bleeding patients through secondary analysis of the PROPPR trial. METHODS: Fibrinolysis was characterized in PROPPR subjects using admission TEG lysis at 30 minutes (LY30) or plasmin-antiplasmin (PAP) levels...
April 16, 2018: Shock
https://www.readbyqxmd.com/read/29663991/-effect-of-hydrogen-rich-water-on-the-chondriosome-damage-and-cytokines-in-brain-tissue-of-rats-with-traumatic-brain-injury
#6
Jiangquan Fu, Qing Lan, Difen Wang, Ying Wang, Ying Liu
OBJECTIVE: To observe the effect of hydrogen-rich water on the chondriosome damage and cytokines change in brain tissue of rats with traumatic brain injury (TBI). METHODS: Fifty-four health male Sprague-Dawley (SD) rats were divided into three groups by random number table: sham group, trauma group (TBI group), and trauma+hydrogen-rich water group (TBI+HW group), the rats in each group were subdivided into 1, 3 and 7 days subgroups according to the time points after trauma, with 6 rats in each subgroup...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29663285/exosomes-in-acquired-neurological-disorders-new-insights-into-pathophysiology-and-treatment
#7
REVIEW
Nicole Osier, Vida Motamedi, Katie Edwards, Ava Puccio, Ramon Diaz-Arrastia, Kimbra Kenney, Jessica Gill
Exosomes are endogenous nanovesicles that play critical roles in intercellular signaling by conveying functional genetic information and proteins between cells. Exosomes readily cross the blood-brain barrier and have promise as therapeutic delivery vehicles that have the potential to specifically deliver molecules to the central nervous system (CNS). This unique feature also makes exosomes attractive as biomarkers in diagnostics, prognostics, and therapeutics in the context of multiple significant public health conditions, including acquired neurological disorders...
April 16, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29663102/docosahexaenoic-acid-dha-provides-neuroprotection-in-traumatic-brain-injury-models-via-activating-nrf2-are-signaling
#8
Wei Zhu, Yuexia Ding, Wei Kong, Tuo Li, Hongguang Chen
In this study, we explored the neuroprotective effects of docosahexaenoic acid (DHA) in traumatic brain injury (TBI) models. In this study, we first confirmed that DHA was neuroprotective against TBI via the NSS test and Morris water maze experiment. Western blot was conducted to identify the expression of Bax, caspase-3, and Bcl-2. And the cell apoptosis of the TBI models was validated by TUNEL staining. Relationships between nuclear factor erythroid 2-related factor 2-antioxidant response element (Nrf2-ARE) pathway-related genes and DHA were explored by RT-PCR and Western blot...
April 16, 2018: Inflammation
https://www.readbyqxmd.com/read/29662944/combined-blockade-of-interleukin-1%C3%AE-and-1%C3%AE-signaling-protects-mice-from-cognitive-dysfunction-after-traumatic-brain-injury
#9
Elizabeth A Newell, Brittany P Todd, Jolonda Mahoney, Andrew A Pieper, Polly J Ferguson, Alexander G Bassuk
Diffuse activation of interleukin-1 inflammatory cytokine signaling after traumatic brain injury (TBI) elicits progressive neurodegeneration and neuropsychiatric dysfunction, and thus represents a potential opportunity for therapeutic intervention. Although interleukin (IL)-1α and IL-1β both activate the common type 1 IL-1 receptor (IL-1RI), they manifest distinct injury-specific roles in some models of neurodegeneration. Despite its potential relevance to treating patients with TBI, however, the individual contributions of IL-1α and IL-1β to TBI-pathology have not been previously investigated...
March 2018: ENeuro
https://www.readbyqxmd.com/read/29662775/relationship-between-heterotopic-ossification-and-traumatic-brain-injury-why-severe-traumatic-brain-injury-increases-the-risk-of-heterotopic-ossification
#10
REVIEW
Huan Huang, Wen-Xiang Cheng, Yi-Ping Hu, Jian-Hai Chen, Zheng-Tan Zheng, Peng Zhang
Heterotopic ossification (HO) is a pathological phenomenon in which ectopic lamellar bone forms in soft tissues. HO involves many predisposing factors, including congenital and postnatal factors. Postnatal HO is usually induced by fracture, burn, neurological damage (brain injury and spinal cord injury) and joint replacement. Recent studies have found that patients who suffered from bone fracture combined with severe traumatic brain injury (S-TBI) are at a significantly increased risk for HO occurrence. Thus, considerable research focused on the influence of S-TBI on fracture healing and bone formation, as well as on the changes in various osteogenic factors with S-TBI occurrence...
January 2018: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29662272/effect-of-bulk-modulus-on-deformation-of-the-brain-under-rotational-accelerations
#11
S Ganpule, N P Daphalapurkar, M Pirtini Cetingul, K T Ramesh
Traumatic brain injury such as that developed as a consequence of blast is a complex injury with a broad range of symptoms and disabilities. Computational models of brain biomechanics hold promise for illuminating the mechanics of traumatic brain injury (TBI) and for developing preventive devices. However, reliable material parameters are needed for models to be predictive. Unfortunately, the properties of human brain tissue are difficult to measure, and the bulk modulus of brain tissue in particular is not well-characterized...
January 2018: Shock Waves
https://www.readbyqxmd.com/read/29662266/thyroid-nodules-and-long-term-follow-up-among-childhood-cancer-survivors-who-underwent-hematopoietic-stem-cell-transplantation
#12
Shunsuke Shimazaki, Itsuro Kazukawa, Maine Ishida, Masanori Minagawa
Thyroid nodules have been observed in childhood cancer survivors (CCS) treated with chemotherapy and radiotherapy. We report four patients with thyroid nodules identified during the long-term follow-up of children who underwent hematopoietic stem cell transplantation (HSCT). The thyroid nodules were diagnosed as adenomatous goiter in all four patients. The interval between the primary cancer diagnosis and the occurrence of the thyroid nodules was more than 10 yr. Furthermore, all four patients underwent HSCT in conditioning with total body irradiation (TBI) before the age of 10 yr...
2018: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29660969/self-regulation-strategies-used-by-students-with-brain-injury-while-transitioning-to-college
#13
Katy H O'Brien, Sarah K Schellinger, Mary R T Kennedy
PURPOSE: Students with TBI enter college with strategies that they have used prior to being injured yet often without knowing which ones will be effective in helping them to be successful. The purpose here is to describe how semi-structured interviews were used to identify self-regulated learning strategies, to demonstrate the utility and reliability of coding self-regulated learning strategies, and to provide examples of student-centered goals derived from survey and interview responses...
April 7, 2018: NeuroRehabilitation
https://www.readbyqxmd.com/read/29660968/rehabilitation-and-school-services-following-traumatic-brain-injury-in-young-children
#14
Juliet Haarbauer-Krupa, Jennifer P Lundine, Roberta DePompei, Tricia Z King
BACKGROUND: Preschool children have the highest incidence of emergency department visits for traumatic brain injury (TBI) with the majority discharged home without a single point of entry into follow-up services. This paper describes families' experience with service access following TBI. OBJECTIVES: To describe parent reported service utilization following preschool TBI and examine predictors of service access. METHODS: Participants (N = 80) were drawn from the first visit of a longitudinal study examining elementary school outcomes following TBI...
April 7, 2018: NeuroRehabilitation
https://www.readbyqxmd.com/read/29660966/community-based-interventions-for-adolescents-following-traumatic-brain-injury-a-systematic-review
#15
Betony Clasby, Nathan Hughes, Cathy Catroppa, Elle Morrison
BACKGROUND: Chronic impairment following childhood traumatic brain injury has the potential to increase risk of negative outcomes. This highlights potential value of community-based rehabilitation programs. OBJECTIVES: To identify research studies examining existing intervention programmes available in community-based rehabilitation to adolescents following TBI to assist with the transition back into the community. METHODS: A systematic review of community-based interventions was conducted across different national contexts...
April 7, 2018: NeuroRehabilitation
https://www.readbyqxmd.com/read/29660965/a-clinically-focused-systematic-review-of-social-communication-in-pediatric-tbi
#16
Angela Hein Ciccia, Leah Beekman, Emily Ditmars
BACKGROUND: Social communication is a persistent area of need after pediatric traumatic brain injury; however, it continues to be misunderstood, under-recognized, and under-treated. Clinicians must have a working understanding of current evidence and practice recommendations to support practice. OBJECTIVES: 1) To analyze recent evidence in social communication published in the last ten years, which is specific to pediatric TBI and 2) To translate these findings for clinicians...
April 7, 2018: NeuroRehabilitation
https://www.readbyqxmd.com/read/29660964/hospital-to-school-transition-following-traumatic-brain-injury-a-qualitative-longitudinal-study
#17
Bonnie Todis, Melissa McCart, Ann Glang
BACKGROUND: The transition from hospital to school is regarded by researchers as a key factor in the educational success of students with traumatic brain injury (TBI). OBJECTIVES: The objective of this study is to look closely at what transition services consist of, how they are delivered, and how they are received by educators. METHODS: Parents and educators of 21 students with TBI participated in a qualitative study of the delivery of transition services and implementation of hospital recommendations...
April 7, 2018: NeuroRehabilitation
https://www.readbyqxmd.com/read/29660963/readiness-to-recognize-a-qualitative-case-study-of-educational-identification-of-tbi
#18
David Greene, Pat L Sample, Nicole Johns, Maureen Palmer
BACKGROUND: The educational identification (ED-ID) of students with traumatic brain injury (TBI) has been legislated in numerous states, and TBI has become its own special education category. Questions abound as to whether these changes will lead to more readily identifying these students to provide appropriate special education supports. OBJECTIVE: Elucidate one state's response to legislative changes around ED-ID of TBI. METHODS: This is a phenomenological case study of nine school districts in one state...
April 7, 2018: NeuroRehabilitation
https://www.readbyqxmd.com/read/29660961/an-international-perspective-on-educators-perceptions-of-children-with-traumatic-brain-injury
#19
Laurie Gutmann Kahn, Mark A Linden, Audrey McKinlay, Doug Gomez, Ann Glang
BACKGROUND: Educators lack understanding of traumatic brain injury (TBI), which can lead to a lack of appropriate assessment and intervention methods for these students. OBJECTIVE(S): This qualitative study explored what experienced teachers perceive, believe, and know about pediatric TBI. METHODS: Following development of a standardized interview protocol, 46 teachers from Australia, New Zealand, Northern Ireland, and the United States took part in semi-structured interviews...
April 7, 2018: NeuroRehabilitation
https://www.readbyqxmd.com/read/29660958/immersive-virtual-reality-in-traumatic-brain-injury-rehabilitation-a-literature-review
#20
Jared Aida, Brian Chau, Justin Dunn
BACKGROUND: Traumatic brain injury (TBI) is a common cause of morbidity and mortality in the United States with its sequelae often affecting individuals long after the initial injury. Innovations in virtual reality (VR) technology may offer potential therapy options in the recovery from such injuries. However, there is currently no consensus regarding the efficacy of VR in the setting of TBI rehabilitation. OBJECTIVE: The aim of this review is to evaluate and summarize the current literature regarding immersive VR in the rehabilitation of those with TBI...
April 7, 2018: NeuroRehabilitation
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