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https://www.readbyqxmd.com/read/28532798/effects-of-intravaginal-lactic-acid-bacteria-on-bovine-endometrium-implications-in-uterine-health
#1
Sandra Genís, Àlex Bach, Anna Arís
Infection and inflammation of the endometrium after calving compromise uterine health, contributing to decreased reproductive efficiency in dairy cows. Twenty multiparous cows were distributed in two groups and treated intra-vaginally with a combination of lactic acid bacteria (LAB) composed by Lactobacillus rhamnosus, Pedioccocus acidilactici, and Lactobacillus reuteri, or with a sterile carrier (CON) twice per week during 3 wk. At the slaughterhouse, vaginal and endometrial swabs were taken for E. coli and Lactobacillus quantification...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28528509/invasive-lobular-carcinoma-with-extracellular-mucin-production-a-novel-pattern-of-lobular-carcinomas-of-the-breast-clinico-pathological-description-of-eight-cases
#2
Gábor Cserni, Giuseppe Floris, Nektarios Koufopoulos, Anikó Kovács, Afroditi Nonni, Peter Regitnig, Anders Stahls, Zsuzsanna Varga
Invasive lobular carcinoma of the breast is known to produce intracellular mucin and has been recognized in single-case reports to show extracellular mucin production, as well. This latter morphology is not only rare but must also be under- or misdiagnosed. The aim was to better characterize this entity. Cases of lobular cancers demonstrating extracellular mucin formation were identified in a multi-institutional effort and their clinical and morphologic features were assessed. Immunohistochemistry was used to characterize the E-cadherin-membrane complex, neuroendocrine differentiation, and to some extent, mucin formation...
May 20, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28522938/mucin-1-antibody-conjugated-mesoporous-silica-nanoparticles-for-selective-breast-cancer-detection-in-a-mucin-1-transgenic-murine-mouse-model
#3
Didier Dréau, Laura Jeffords Moore, Merlis P Alvarez-Berrios, Mubin Tarannum, Pinku Mukherjee, Juan L Vivero-Escoto
Mucin-1 (MUC1), a transmembrane glycoprotein is aberrantly expressed on ~90% of breast cancer and is an excellent target for nanoparticulate targeted imaging. In this study, the development of a dye-doped NIR emitting mesoporous silica nanoparticles platform conjugated to tumor-specific MUC1 antibody (ab-tMUC1-NIR-MSN) for in vivo optical detection of breast adenocarcinoma tissue is reported. The structural properties, the in vitro and in vivo performance of this nanoparticle-based probe were evaluated. In vitro studies showed that the MSN-based optical imaging nanoprobe is non-cytotoxic and targets efficiently mammary cancer cells overexpressing human tMUC1 protein...
December 2016: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/28505002/immunohistochemical-classification-of-ampullary-carcinomas-critical-reappraisal-fails-to-confirm-prognostic-relevance-for-recently-proposed-panels-and-highlights-muc5ac-as-a-strong-prognosticator
#4
Yue Xue, Michelle D Reid, Serdar Balci, Brian Quigley, Takashi Muraki, Bahar Memis, Jun Xia, Ezgi Hacihasanoglu, Gabriela Bedolla, Burcin Pehlivanoglu, Grace E Kim, Takuma Tajiri, Nobuyike Ohike, Ritu Aneja, Alyssa M Krasinskas, Volkan Adsay
Recently, immunohistochemistry-based classifications of ampullary carcinomas have been proposed (Ang and colleagues [PMID: 24832159]; Chang and colleagues [PMID: 23439753]). In this study, the prognostic value of Ang/Chang panel markers (CK20, MUC1, MUC2, CDX2) as well as other markers (CK7, MUC5AC, and MUC6) were tested on full-faced sections of 136 ampullary carcinoma resections with substantial (>5 mm) invasion. Immunohistochemistry was correlated with both histologic classification (intestinal [INT], pancreatobiliary [PB], or nontubular based on ≥3/5 observer agreement) and clinical outcome...
May 12, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28502165/grape-seed-proanthocyanidin-inhibits-mucin-synthesis-and-viral-replication-by-suppression-of-ap-1-and-nf-%C3%AE%C2%BAb-via-p38-mapks-jnk-signaling-pathways-in-respiratory-syncytial-virus-infected-a549-cells
#5
Jin-Woo Lee, Young Il Kim, Chang-Nim Im, Sung Wan Kim, Su Jin Kim, Seoyeon Min, Yong Hoon Joo, Sung-Vin Yim, Namhyun Chung
Airway epithelial cells are often infected by respiratory syncytial virus (RSV), one of the most common causes of asthma, bronchiolitis, chronic obstructive pulmonary disease (COPD), and pneumonia. During the infection process, excessive mucins aggravate airway inflammation. However, the mechanism underlying RSV-induced airway hyperresponsiveness and inflammation is poorly understood. Furthermore, no reliable vaccines or drugs for antiviral therapy are available. In this study, the effect of the natural compound grape seed proanthocyanidin (GSP) on RSV-infected human airway epithelial cells A549 was evaluated...
May 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28495579/a-new-chemotherapy-agent-free-theranostic-system-composed-of-graphene-oxide-nano-complex-and-aptamers-for-treatment-of-cancer-cells
#6
Amirhossein Bahreyni, Rezvan Yazdian-Robati, Shirin Hashemitabar, Mohammad Ramezani, Pouria Ramezani, Khalil Abnous, Seyed Mohammad Taghdisi
The common cancer treatment strategies like chemotherapy and radiotherapy are nonspecific and can trigger severe side effects by damaging normal cells. So, targeted cancer therapies, such as apoptosis induction, have attracted great attention in recent years. In this project, two nano-complexes, MUC1 aptamer-NAS-24 aptamer-Graphene oxide (GO) and MUC1 aptamer-Cytochrome C aptamer-GO, were designed to induce cell programmed death in MDA-MB-231 and MCF-7 cells (breast cancer cell lines) and to verify the level of apoptosis in both cell lines...
May 8, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28489708/muc1-muc5ac-and-muc6-polymorphisms-helicobacter-pylori-infection-and-gastric-cancer-a-systematic-review-and-meta-analysis
#7
Luca Giraldi, Maria B Michelazzo, Dario Arzani, Roberto Persiani, Roberta Pastorino, Stefania Boccia
The risk of Helicobacter pylori (HP) infection, as well as gastric cancer (GC), in association with genetic polymorphisms of gene encoding for mucins, has been investigated with contradictory results. We carried out this systematic review and meta-analysis to summarize the relationship between MUC1, MUC5AC, and MUC6 polymorphisms and HP infection, as well as GC risk. We searched MEDLINE, ISI Web of Science, Scopus bibliographic databases and the HuGE Navigator database. Odds ratios (ORs) and 95% confidence interval (CI) were calculated to assess the association between the genetic polymorphisms, and HP/GC risk...
May 1, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28482827/mucin-1-a-signal-transduction-membrane-bound-mucin-is-present-in-human-disc-tissue-and-is-downregulated-in-vitro-by-exposure-to-il-1%C3%A3-or-tnf-%C3%AE
#8
Helen E Gruber, Jane A Ingram, Gretchen L Hoelscher, Emilio Marrero, Edward N Hanley
BACKGROUND: Back pain and disc degeneration have a growing socioeconomic healthcare impact. Mucin 1 (MUC1) is a transmembrane glycoprotein whose extracellular and intracellular domains participate in cellular signaling. Little is currently known about the presence or role of MUC1 in human disc degeneration. METHODS: In this IRB-approved research study, 29 human disc specimens were analyzed for MUC1 immunohistochemical localization and gene expression, and annulus fibrosus (annulus) cells were also isolated and cultured in 3D...
May 8, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28472347/muc1-knockout-potentiates-murine-lung-carcinogenesis-involving-an-epiregulin-mediated-egfr-activation-feedback-loop
#9
Xiuling Xu, Wenshu Chen, Shuguang Leng, Mabel T Padilla, Bryanna Saxton, Julie Hutt, Mathewos Tessema, Kosuke Kato, Kwang Chul Kim, Steven A Belinsky, Yong Lin
Although MUC1 is believed to be an oncoprotein, this study uncovers cell-type specific functions of MUC1 in the tumor microenvironment. Our results add complexity to the roles of MUC1 in cancer and help to develop intervention approaches against lung cancer.
May 4, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28470556/critical-roles-of-mucin-1-in-sensitivity-of-lung-cancer-cells-to-tumor-necrosis-factor-alpha-and-dexamethasone
#10
Menglin Xu, Xiangdong Wang
Lung cancer is the leading cause of death from cancer. Mucins are glycoproteins with high molecular weight, responsible for cell growth, differentiation, and signaling, and were proposed to be correlated with gene heterogeneity of lung cancer. Here, we report aberrant expression of mucin genes and tumor necrosis factor receptors in lung adenocarcinoma tissues compared with normal tissues in GEO datasets. Mucin-1 (MUC1) gene was selected and considered as the target gene; furthermore, the expression pattern of adenocarcinomic cells (A549, H1650, or H1299 cells) was validated under the stimulation with tumor necrosis factor-alpha (TNFα) or dexamethasone (DEX), separately...
May 3, 2017: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/28464016/muc1-facilitates-metabolomic-reprogramming-in-triple-negative-breast-cancer
#11
Gennifer Goode, Venugopal Gunda, Nina V Chaika, Vinee Purohit, Fang Yu, Pankaj K Singh
BACKGROUND: Mucin1 (MUC1), a glycoprotein associated with chemoresistance and an aggressive cancer phenotype, is aberrantly overexpressed in triple-negative breast cancer (TNBC). Recent studies suggest that MUC1 plays a role in modulating cancer cell metabolism and thereby supports tumor growth. Herein, we examined the role of MUC1 in metabolic reprogramming in TNBC. METHODS: MUC1 was stably overexpressed in MDA-MB-231 TNBC cells and stably knocked down in MDA-MB-468 cells...
2017: PloS One
https://www.readbyqxmd.com/read/28455135/sn38-conjugated-hyaluronic-acid-gold-nanoparticles-as-a-novel-system-against-metastatic-colon-cancer-cells
#12
Hosniyeh Hosseinzadeh, Fatemeh Atyabi, Behrang Shiri Varnamkhasti, Reza Hosseinzadeh, Seyed Nasser Ostad, Mohammad Hossein Ghahremani, Rassoul Dinarvand
Combination of chemotherapy and photothermal therapy has been proposed for better treatment of metastatic colon cancer. In this study SN38, a highly potent cytotoxic agent, was conjugated to negatively charged hyaluronic acid (HA), which was deposited on the surface of the positively charged gold nanoparticles via electrostatic interaction. The drug conjugation and its interaction with gold nanoparticles were verified by (1)H NMR and UV-vis spectroscopies, respectively. The prepared SN38-HA gold NPs are negatively charged spherical nanoparticles with an average size of 75±10nm...
April 25, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28454381/optimized-construction-of-muc1-vntrn-dna-vaccine-and-its-anti-pancreatic-cancer-efficacy
#13
Yuan-Feng Gong, Quan-Bo Zhou, Ya-Di Liao, Cong Mai, Tie-Jun Chen, Yun-Qiang Tang, Ru-Fu Chen
Considering mucin 1-variable number tandem repeat (MUC1-VNTRn) as a novel target for pancreatic cancer immunotherapy, the present study aimed to screen and identify the pVAX1-MUC1-VNTRn DNA vaccine with the strongest immunogenicity. Following construction of a pVAX1-MUC1-VNTRn plasmid, immature dendritic cells (DCs) were subjected to transfection, and mature DCs were then co-cultured with autologous T-cells. The numbers of cytotoxic T lymphocytes (CTLs) secreting interferon (IFN)-γ were determined using an enzyme-linked immunospot assay, and CytoTox(®) was also used to examine the MUC1-VNTRn-specific Lethal effect of CTLs on Capan2 cells...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28453172/phenotypic-classification-of-gastric-signet-ring-cell-carcinoma-and-its-relationship-with-k-ras-mutation
#14
Z F Xiong, J Shi, Z H Fu, H P Wan, L X Tu
We aimed to analyze gastric signet ring cell (SRC) carcinoma subtypes by investigating gastric and intestinal phenotypic marker expression, and explore the relationship between phenotype and K-ras mutation. Immunohistochemistry was performed on 163 SRC carcinoma patient specimens to detect gastric (MUC1, MUC5AC, and MUC6) and intestinal (MUC2 and CDX2) phenotypic markers, and tumors were classified into gastric (G), intestinal (I), and gastrointestinal (GI) phenotypes. DNA was extracted from the formalin-fixed, paraffin-embedded tumor samples, and K-ras mutations in codons 12, 13, and 61 were identified using polymerase chain reaction-based direct DNA sequencing...
April 28, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28451462/pulmonary-adenocarcinoma-with-mucin-production-modulates-phenotype-according-to-common-genetic-traits-a-reappraisal-of-mucinous-adenocarcinoma-and-colloid-adenocarcinoma
#15
Angelica Sonzogni, Fabrizio Bianchi, Alessandra Fabbri, Mara Cossa, Giulio Rossi, Alberto Cavazza, Elena Tamborini, Federica Perrone, Adele Busico, Iolanda Capone, Benedetta Picciani, Barbara Valeri, Ugo Pastorino, Giuseppe Pelosi
Whether invasive mucinous adenocarcinoma (IMA) and colloid adenocarcinoma (ICA) of the lung represent separate tumour entities, or simply lie within a spectrum of phenotypic variability, is worth investigating. Fifteen ICA, 12 IMA, 9 ALK-rearranged adenocarcinomas (ALKA), 8 non-mucinous KRAS-mutated adenocarcinomas (KRASA) and 9 mucinous breast adenocarcinomas (MBA) were assessed by immunohistochemistry for alveolar (TTF1, cytoplasmic MUC1), intestinal (CDX-2, MUC2), gastric (membrane MUC1, MUC6), bronchial (MUC5AC), mesenchymal (vimentin), neuroendocrine (chromogranin A, synaptophysin), sex steroid hormone-related (oestrogen and progesterone receptors), pan-mucinous (HNF4A) and pan-epithelial (keratin 7) lineage biomarkers and by targeted next generation sequencing (TNGS) for 50 recurrently altered cancer genes...
April 2017: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/28451120/total-chemical-synthesis-of-proteins-without-hplc-purification
#16
S F Loibl, Z Harpaz, R Zitterbart, O Seitz
The total chemical synthesis of proteins is a tedious and time-consuming endeavour. The typical steps involve solid phase synthesis of peptide thioesters and cysteinyl peptides, native chemical ligation (NCL) in solution, desulfurization or removal of ligation auxiliaries in the case of extended NCL as well as many intermediary and final HPLC purification steps. With an aim to facilitate and improve the throughput of protein synthesis we developed the first method for the rapid chemical total on-resin synthesis of proteins that proceeds without a single HPLC-purification step...
November 1, 2016: Chemical Science
https://www.readbyqxmd.com/read/28450780/new-generation-of-electrochemical-immunoassay-based-on-polymeric-nanoparticles-for-early-detection-of-breast-cancer
#17
Fouzi Mouffouk, Sihem Aouabdi, Entesar Al-Hetlani, Hacene Serrai, Tareq Alrefae, Liaohai Leo Chen
Screening and early diagnosis are the key factors for the reduction of mortality rate and treatment cost of cancer. Therefore, sensitive and selective methods that can reveal the low abundance of cancer biomarkers in a biological sample are always desired. Here, we report the development of a novel electrochemical biosensor for early detection of breast cancer by using bioconjugated self-assembled pH-responsive polymeric micelles. The micelles were loaded with ferrocene molecules as "tracers" to specifically target cell surface-associated epithelial mucin (MUC1), a biomarker for breast and other solid carcinoma...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28447743/binding-of-circulating-anti-muc1-antibody-and-serum-muc1-antigen-in-stage-iv-breast-cancer
#18
Yan Tang, Xiuxia Cui, Han Xiao, Shengkun Qi, Xiaoping Hu, Qiong Yu, Guang Shi, Xue Zhang, Jiaying Gu, Yongli Yu, Liying Wang, Yarong Li
The present study aimed to investigate the binding of circulating mucin 1 (MUC1) antibody with serum MUC1 antigen in stage IV breast cancer. Serum samples of 61 patients with stage IV breast cancer and 64 patients with early-stage breast cancer were collected. The anti‑MUC1 antibody (IgG) and MUC1 antigen (cancer antigen 15‑3; Ca15‑3) were detected using an indirect enzyme-linked immunosorbent assay (I‑ELISA) and ELISA, respectively. The MUC1 IgG affinity was detected using a urea degradation combining ELISA...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28443527/an-investigation-into-the-effects-of-maternal-supplementation-with-excess-iodine-on-the-mechanisms-and-impacts-of-reduced-igg-absorption-in-the-lamb-postpartum
#19
F M McGovern, T Sweeney, M T Ryan, S Lott, F P Campion, T M Boland
An experiment was conducted to determine: (1) the effect of excess maternal I supplementation on the thyroid hormone status of the ewe and her progeny; (2) potential mechanisms underpinning the failure of passive transfer associated with excess I and (3) the growing lambs' response to natural gastrointestinal infection. Twin-bearing ewes received one of two treatments (n 32/treatment group): basal diet (C) or C plus 26·6 mg of iodine/ewe per d (I), supplied as calcium iodate. Ewes were individually fed from day 119 of gestation to parturition...
April 26, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28440596/immunogenicity-of-a-fully-synthetic-muc1-glycopeptide-antitumor-vaccine-enhanced-by-poly-i-c-as-a-tlr3-activating-adjuvant
#20
Markus Glaffig, Natascha Stergiou, Edgar Schmitt, Horst Kunz
Fully synthetic MUC1 glycopeptide antitumor vaccines have a precisely specified structure and induce a targeted immune response without suppression of the immune response when using an immunogenic carrier protein. However, tumor-associated aberrantly glycosylated MUC1 glycopeptides are endogenous structures, "self-antigens", that exhibit only low immunogenicity. To overcome this obstacle, a fully synthetic MUC1 glycopeptide antitumor vaccine was combined with poly(inosinic acid:cytidylic acid), poly(I:C), as a structurally defined Toll-like receptor 3 (TLR3)-activating adjuvant...
April 25, 2017: ChemMedChem
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