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https://www.readbyqxmd.com/read/28643330/muc1-c-is-a-target-in-lenalidomide-resistant-multiple-myeloma
#1
Li Yin, Ashujit Tagde, Reddy Gali, Yu-Tzu Tai, Teru Hideshima, Kenneth Anderson, David Avigan, Donald Kufe
Lenalidomide (LEN) acts directly on multiple myeloma (MM) cells by inducing cereblon-mediated degradation of interferon regulatory factor 4, Ikaros (IKZF)1 and IKZF3, transcription factors that are essential for MM cell survival. The mucin 1 (MUC1) C-terminal transmembrane subunit (MUC1-C) oncoprotein is aberrantly expressed by MM cells and protects against reactive oxygen species (ROS)-mediated MM cell death. The present studies demonstrate that targeting MUC1-C with GO-203, a cell-penetrating peptide inhibitor of MUC1-C homodimerization, is more than additive with LEN in downregulating the WNT/β-catenin pathway, suppressing MYC, and inducing late apoptosis/necrosis...
June 23, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28628803/mucoepidermoid-carcinoma-associated-expression-of-muc5ac-muc5b-and-mucin-type-carbohydrate-antigen-sialyl-tn-in-the-parotid-gland
#2
Johannes H Matse, Wiresh K Bharos, Enno C I Veerman, Elisabeth Bloemena, Jan G M Bolscher
OBJECTIVES: The aberrant expression of mucins and mucin-type carbohydrates has been described in many types of cancer, including mucoepidermoid carcinoma (MEC), a malignant salivary gland tumor. In this study, we examined the aberrant expression patterns of mucins (MUC1, MUC4, MUC5AC and MUC5B), simple mucin-type carbohydrate antigens (Tn, sialyl-Tn and T) and mature carbohydrate antigens (Lewis(a) and sulfo-Lewis(a) antigens) in MEC originating from the parotid gland, which normally does not secrete mucins...
June 13, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28622163/novel-roles-for-mucin-1-in-the-kidney
#3
Mohammad M Al-Bataineh, Rebecca P Hughey
PURPOSE OF REVIEW: Recent studies in the kidney have revealed that the well characterized tumor antigen mucin 1 (MUC1/Muc1) also has numerous functions in the normal and injured kidney. RECENT FINDINGS: Mucin 1 is a transmembrane mucin with a robust glycan-dependent apical targeting signal and efficient recycling from endosomes. It was recently reported that the TRPV5 calcium channel is stabilized on the cell surface by galectin-dependent cross-linking to mucin 1, providing a novel mechanism for regulation of ion channels and normal electrolyte balance...
June 15, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28622066/vascular-associated-muc4-vwf-co-localization-in-human-conjunctival-malignant-melanoma-specimens-tumor-metastasis-by-migration
#4
Vinodh Kakkassery, Sibylle Winterhalter, Ann-Christin Nick, Stephanie C Joachim, Antonia M Joussen, Norbert Kociok
PURPOSE: To investigate whether vascular differentiation marker von Willebrand factor (vWf) and proliferation marker KI67 expression correlate with MUC4 localization around stromal tumor vascularization in human conjunctival malignant melanoma (CMM). MATERIALS AND METHODS: For the purposes of this study, we analyzed samples from human CMMs (n = 4), conjunctival compound nevi (n = 7), and samples from healthy conjunctiva (n = 7) for MUC1, 4, and 16 by immunohistochemistry...
June 16, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28618938/laboratory-validation-of-formal-concept-analysis-of-the-methylation-status-of-microarray-detected-genes-in-primary-breast-cancer
#5
Samar K Kassim, Hanan H Shehata, Marwa M Abou-Alhussein, Maha M Sallam, Islam Ibrahim Amin
Breast cancer is the leading cause of cancer-related mortality. DNA methylations play important roles in cancer development and progression. Formal concept analysis was previously utilized for data mining hypermethylated and hypomethylated genes in breast cancer molecular subtypes in illumina methylation-based microarray database, to laboratory validate their outputs; HS3ST2 (heparan sulfate d-glucosaminyl 3-O-sulfonyl transferase-2) and MUC1 (mucin-1) were retrieved. Both play important roles in progression and invasion of breast cancer...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28616090/histochemical-and-immunohistochemical-study-of-mucinous-rectal-carcinoma
#6
C V Lungulescu, S Răileanu, G Afrem, B S Ungureanu, D N Florescu, I A Gheonea, S Șovăilă, Ș Crăițoiu
Colorectal cancer (CRC) is a major health problem worldwide. The objective of our study was to assess the histopathological (HP) and immunohistochemical (IHC) profile of mucins from signet ring (SR) and mucinous rectal carcinoma, while evaluating their value as a prognostic factor and muco-secretive ability. The HP study (76 cases) included 4 categories of patients: pure mucinous (PM), mixed mucinous components (MM) (50-80% of the tumor cells), mixed mucinous components (Mm) (< 50% of the tumor cells) and signet ring (SR)...
April 2017: Journal of Medicine and Life
https://www.readbyqxmd.com/read/28605238/mucin-1-protects-against-severe-streptococcus-pneumoniae-infection
#7
Poshmaal Dhar, Garrett Z Ng, Eileen M Dunne, Philip Sutton
Streptococcus pneumoniae is a bacterial pathogen that commonly resides in the human nasopharynx, typically without causing any disease. However, in some cases these bacteria migrate from the nasopharynx to other sites of the body such as the lungs and bloodstream causing pneumonia and sepsis, respectively. This study used a mouse model of infection to investigate the potential role of Mucin 1 (MUC1), a cell membrane-associated glycoprotein known for playing a key barrier role at mucosal surfaces, in regulating this process...
June 12, 2017: Virulence
https://www.readbyqxmd.com/read/28597750/muc1-induces-tamoxifen-resistance-in-estrogen-receptor-positive-breast-cancer
#8
Parnaz Merikhian, Reyhane Ghadirian, Leila Farahmand, Sepideh Mansouri, Keivan Majidzadeh-A
Tamoxifen, as an essential therapeutic tool in the treatment of estrogen receptor-positive breast cancer, has been available for the past three decades and is currently being utilized as a chemo-preventive agent for patients at high risk for breast carcinoma. However, the induction of chemo-resistance during therapy has indicated a significant challenge with regards to this agent. Areas covered: This review enumerates the role of MUC1-C proto-oncogene in tamoxifen resistance and describes a number of signaling pathways by which MUC1-C would mediate the development of resistance...
June 21, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28588132/enteroaggregative-escherichia-coli-adherence-fimbriae-drive-inflammatory-cell-recruitment-via-interactions-with-epithelial-muc1
#9
Erik J Boll, Jorge Ayala-Lujan, Rose L Szabady, Christopher Louissaint, Rachel Z Smith, Karen A Krogfelt, James P Nataro, Fernando Ruiz-Perez, Beth A McCormick
Enteroaggregative Escherichia coli (EAEC) causes diarrhea and intestinal inflammation worldwide. EAEC strains are characterized by the presence of aggregative adherence fimbriae (AAF), which play a key role in pathogenesis by mediating attachment to the intestinal mucosa and by triggering host inflammatory responses. Here, we identify the epithelial transmembrane mucin MUC1 as an intestinal host cell receptor for EAEC, demonstrating that AAF-mediated interactions between EAEC and MUC1 facilitate enhanced bacterial adhesion...
June 6, 2017: MBio
https://www.readbyqxmd.com/read/28586014/lewis-y-antigen-promotes-the-progression-of-epithelial-ovarian-cancer-by-stimulating-muc1-expression
#10
Rui Hou, Luo Jiang, Dawo Liu, Bei Lin, Zhenhua Hu, Jian Gao, Danye Zhang, Shulan Zhang, Masao Iwamori
MUC1 is a type I transmembrane glycoprotein and is overexpressed in various epithelial tumor tissues. Some researchers have demonstrated that the glycosylation status of MUC1 can affect MUC1-mediated tumor growth and cell differentiation. In our previous study, we proved that the abilities of cell proliferation, adhesion, invasion and metastasis, and drug resistance were enhanced in ovarian cancer cells stably expressing Lewis(y). Therefore, we hypothesized that Lewis(y) antigen may play a central role in regulating MUC1 expression, and MUC1-mediated cell growth and differentiation may be closely associated with Lewis(y) antigen...
June 2, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28581490/assessment-of-tumor-characteristics-based-on-glycoform-analysis-of-membrane-tethered-muc1
#11
Atsushi Matsuda, Michiyo Higashi, Tomomi Nakagawa, Seiya Yokoyama, Atsushi Kuno, Suguru Yonezawa, Hisashi Narimatsu
Clinical tissue specimens are useful for pathological diagnosis, which is, in some cases, supported by visualization of biomolecule localization. In general, diagnostic specificity in molecular pathology is increased by the acquisition of a probe to distinguish the modification of isomers. Although glycosylation is one of the candidate modifications in a protein, comparative glycan analysis of disease-associated proteins derived from a single tissue section is still challenging because of the lack of analytical sensitivity...
June 5, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28579308/a-dual-functional-peptide-auxiliary-conjugate-for-c-to-n-and-n-to-c-sequential-native-chemical-ligation-of-glycopeptides
#12
Claudia Bello, Christian F W Becker
Long, homogeneously glycosylated peptides and proteins can be assembled from multiple segments via sequential chemoselective reactions. The efficiency of the synthesis depends on the effectiveness and number of steps and on their compatibility with glycosylation methods. Here, we present how the combination of auxiliary-mediated native chemical ligation and thioester generation via hydrazinolysis from Wang-type resin enables multiple, sequential N-to-C and C-to-N ligations. The method can be applied to glycosylated peptides and peptide α-thioesters and has the potential to be further extended to sequential glycosylation, thus paving the way to the synthesis of complex homogeneous glycoproteins...
May 22, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28577958/lepidic-predominant-adenocarcinoma-and-invasive-mucinous-adenocarcinoma-of-the-lung-exhibit-specific-mucin-expression-in-relation-with-oncogenic-drivers
#13
Duruisseaux Michaël, Antoine Martine, Rabbe Nathalie, Rodenas Anita, Mc Leer-Florin Anne, Lacave Roger, Poulot Virginie, Duchêne Belinda, Van Seuningen Isabelle, Cadranel Jacques, Wislez Marie
OBJECTIVES: To evaluate MUC1, MUC2, MUC5B, MUC5AC, and MUC6 expression in invasive lepidic predominant adenocarcinoma (LPA) and invasive mucinous adenocarcinoma (IMA) of the lung, and the impact of oncogenic drivers. MATERIALS AND METHODS: MUC1, MUC2, MUC5B, MUC5AC, MUC6, TTF1 and Hnf4α immunohistochemistry was performed on surgical samples from 52 patients with IMA (n=25) or LPA (n=27). We searched for EGFR, KRAS, BRAF, and HER2 mutations and ALK, ROS1, and NRG1 rearrangements...
July 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28575854/genomic-alterations-in-mucins-across-cancers
#14
Ryan J King, Fang Yu, Pankaj K Singh
The significance of mucins in cancers has led to the development of novel biomarkers and therapeutic agents against cancers. Despite significant advances in the understanding of mucins, systemic investigations into the role of mucins in cancer biology focusing particularly on the histological subtypes and stages, along with other variables, are yet to be carried out to discover potential novel functions and cancer-specific roles. Here, we investigated 11 mucin expressing cancers for DNA mutations, mRNA expression, copy number, methylation, and the impacts these genomic features may have on patient survival by utilizing The Cancer Genome Atlas dataset...
May 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28574628/a-boronic-acid-assay-for-the-detection-of-mucin-1-glycoprotein-from-cancer-cells
#15
Xiaoyu Zhang, Shiqiang Zhang, Seung Baek, Michael D Best
Cell surface glycoproteins are commonly aberrant in disease and act as biomarkers that facilitate diagnostics. MUC1 is a prominent example exhibiting truncated glyscosylation in cancer. We present a boronic acid microplate assay for sensitive and high-throughput detection of such glycoproteins. Here, the immobilization of biotinboronic acid 1 onto streptavidin plates generates a multivalent surface for glycoprotein recruitment and detection. We first validated the binding properties of 1 in solution through titrations with alizarin dye...
June 2, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28571146/immunohistochemical-study-of-muc1-muc2-and-muc5ac-expression-in-primary-breast-carcinoma
#16
Daxesh Shivabhai Patel, Siddhi Gaurish Sinai Khandeparkar, Avinash R Joshi, Maithili Mandar Kulkarni, Bhagyashree Dhande, Pranoti Lengare, Lokesh Ashok Phegade, Ketan Narkhede
INTRODUCTION: Breast Cancer (BC) is the second most common cancer among women in India and accounts for 7% of global burden of BC and one-fifth of all Cancers (CA) among women in India. AIM: This study was conducted for studying the expression of MUC1, MUC2 and MUC5AC in breast carcinoma. MATERIALS AND METHODS: Fifty cases of primary breast carcinoma diagnosed between years 2013 to 2015 were included in the study. Manual tissue array technique was applied for cases subjected to Immunohistochemistry (IHC)...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28570622/correction-muc1-facilitates-metabolomic-reprogramming-in-triple-negative-breast-cancer
#17
Gennifer Goode, Venugopal Gunda, Nina V Chaika, Vinee Purohit, Fang Yu, Pankaj K Singh
[This corrects the article DOI: 10.1371/journal.pone.0176820.].
2017: PloS One
https://www.readbyqxmd.com/read/28570009/mucinous-cystic-neoplasms-of-the-liver-and-pancreas-relationship-between-kras-driver-mutations-and-disease-progression
#18
Kohei Fujikura, Masayuki Akita, Shiho Abe-Suzuki, Tomoo Itoh, Yoh Zen
AIMS: To compare the oncogenic mutation status among mucinous cystic neoplasms (MCNs) of different histological grades and between liver and pancreatic MCNs. METHODS AND RESULTS: KRAS, GNAS, RNF43 and PIK3CA were sequenced in 25 surgical cases of hepatopancreatic MCNs. Molecular features were correlated with clinicopathological and immunohistochemical findings. KRAS mutations were identified in 5 cases (20%), while GNAS, RNF43 and PIK3CA were the wild-type in all cases...
June 1, 2017: Histopathology
https://www.readbyqxmd.com/read/28561882/muc1-rs4072037-polymorphism-is-associated-with-decreased-risk-of-gastric-cancer-a-meta-analysis
#19
Yu Ye, Chong Yang, Lei Xu, Dilong Fang
BACKGROUND: Several studies have recently investigated the association between mucin 1 (MUC1) rs4072037 polymorphism and gastric cancer (GC) risk, but with conflicting results. The aim of this meta-analysis was to evaluate the association between MUC1 rs4072037 polymorphism and GC risk. METHODS: A comprehensive database search of PubMed, Elsevier, Embase and China National Knowledge Infrastructure (CNKI) databases was performed to identify relevant studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of any association...
May 26, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28557363/localized-chemical-remodeling-for-live-cell-imaging-of-protein-specific-glycoform
#20
Jingjing Hui, Lei Bao, Siqiao Li, Yi Zhang, Yimei Feng, Lin Ding, Huangxian Ju
Live cell imaging of protein-specific glycoforms is important for the elucidation of glycosylation mechanisms and identification of disease states. The currently used metabolic oligosaccharide engineering (MOE) technology permits routinely global chemical remodeling (GCM) for carbohydrate site of interest, but can exert unnecessary whole-cell scale perturbation and generate unpredictable metabolic efficiency issue. A localized chemical remodeling (LCM) strategy for efficient and reliable access to protein-specific glycoform information is reported...
May 29, 2017: Angewandte Chemie
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