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https://www.readbyqxmd.com/read/28088327/cftr-impairment-upregulates-c-src-activity-through-il-1%C3%AE-autocrine-signaling
#1
María Macarena Massip-Copiz, Mariángeles Clauzure, Ángel Gabriel Valdivieso, Tomás Antonio Santa-Coloma
Cystic Fibrosis (CF) is a disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Previously, we found several genes showing a differential expression in CFDE cells (epithelial cells derived from a CF patient). One corresponded to c-Src; its expression and activity was found increased in CFDE cells, acting as a signaling molecule between the CFTR activity and MUC1 overexpression. Here we report that bronchial IB3-1 cells (CF cells) also showed increased c-Src activity compared to 'CFTR-corrected' S9 cells...
January 11, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28068458/synthetic-muc1-glycopeptide-bearing-%C3%AE-galnac-thr-as-tn-antigen-isomer-induces-antibodies-production-against-tumor-cells
#2
Vanessa Leiria Campo, Thalita Riul, Leandro Bortot, Maristela Martins-Teixeira, Marcelo Marchiori, Emanuela Iaccarino, Menotti Ruvo, Marcelo Dias-Baruffi, Ivone Carvalho
This study presents the synthesis of the novel protected O-glycosyl amino acids βGalNAc-SerOBn (1) and βGalNAc-ThrOBn (2) as mimetics of the natural Tn antigen (αGalNAc-Ser/Thr), along with the solid-phase assembly of the glycopeptides NHAcSer-Ala-Pro-Asp-Thr[αGalNAc]-Arg-Pro-Ala-Pro-Gly-BSA (3-BSA) and NHAcSer-Ala-Pro-Asp-Thr[βGalNAc]-Arg-Pro-Ala-Pro-Gly-BSA (4-BSA), bearing αGalNAc-Thr or βGalNAc-Thr, as mimetics of MUC1 tumor mucin glycoproteins. According to ELISA tests, mice immunizations with βGalNAc-glycopeptide 4-BSA induced higher sera titers (1:320000) if compared to immunizations with αGalNAc-glycopeptide 3-BSA (1:40000)...
January 9, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28053523/anti-muc1-nano-aptamers-for-triple-negative-breast-cancer-imaging-by-single-photon-emission-computed-tomography-in-inducted-animals-initial-considerations
#3
Fagner Santos do Carmo, Eduardo Ricci-Junior, Cristal Cerqueira-Coutinho, Marta de Souza Albernaz, Emerson Soares Bernardes, Sotiris Missailidis, Ralph Santos-Oliveira
The early and specific detection of tumors remains a barrier in oncology, especially in cases such as the triple-negative breast cancer (TNBC). To address this gap, aptamers have found an important application in the recognition of tumor biomarkers such as mucin 1 (MUC1). However, there are still some difficulties in the use of aptamer, as their rapid biological clearance makes their use as drugs limited. In this study, the anti-MUC1 aptamer was used as a drug delivery system (DDS) for a radioactive polymeric nanoparticle (NP) in the imaging of TNBCs...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28039441/muc1-c-drives-dna-methylation-in-cancer
#4
Hasan Rajabi, Ashujit Tagde, Donald Kufe
No abstract text is available yet for this article.
December 28, 2016: Aging
https://www.readbyqxmd.com/read/28038473/gene-expression-changes-in-tumor-free-tongue-tissue-adjacent-to-tongue-squamous-cell-carcinoma
#5
Linda Boldrup, Xiaolian Gu, Philip J Coates, Lena Norberg-Spaak, Robin Fahraeus, Göran Laurell, Torben Wilms, Karin Nylander
Due to the high frequency of loco-regional recurrences, which could be explained by changes in the field surrounding the tumor, patients with squamous cell carcinoma of head and neck show poor survival. Here we identified a total of 554 genes as dysregulated in clinically tumor free tongue tissue in patients with tongue tumors when compared to healthy control tongue tissue. Among the top dysregulated genes when comparing control and tumor free tissue were those involved in apoptosis (CIDEC, MUC1, ZBTB16, PRNP, ECT2), immune response (IFI27) and differentiation (KRT36)...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/28035320/clinical-significance-of-early-changes-in%C3%A2-circulating-tumor-cells-from-patients-receiving-first-line-cisplatin-based-chemotherapy-for-metastatic-urothelial-carcinoma
#6
Emanuela Fina, Andrea Necchi, Patrizia Giannatempo, Maurizio Colecchia, Daniele Raggi, Maria Grazia Daidone, Vera Cappelletti
Background: The therapeutic paradigm of metastatic urothelial carcinoma (UC) is rapidly shifting and new biomarkers are needed to enhance patient selection. Objective: Early identification of dynamic predictors of outcome may be a key to optimize the sequence of effective therapies in metastatic UC patients. Methods: Blood samples from patients receiving first-line MVAC chemotherapy were collected at baseline (T0) and after 2 cycles (T2). Samples were processed by immunomagnetic beads (AdnaTest ProstateCancerSelect kit) and the expression of EPCAM, MUC1 and ERBB2 was studied using multiplex-PCR...
October 27, 2016: Bladder Cancer
https://www.readbyqxmd.com/read/28029038/dual-electrochemiluminescence-signal-system-for-in-situ-and-simultaneous-evaluation-of-multiple-cell-surface-receptors
#7
Bin Zhou, Youyi Qiu, Qingqing Wen, Mingyao Zhu, Peihui Yang
A mutiplex cytosensor based on a dual electrochemiluminescence (ECL) signal system was fabricated for in situ and simultaneous detection of the expression levels of multiple cell-surface receptors, mannose and epidermal growth factor receptor (EGFR), using luminol-capped gold nanoparticles (Au@luminol) and CdS quantum dots (CdS QDs) as potential-resolved ECL nanoprobes. Two spatially resolved areas on indium tin oxide (ITO) electrodes were modified with polyaniline (PANI) by electropolymerization, on which gold nanoparticles (AuNPs) were attached to strengthen conductivity and stability of the sensing interface...
January 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28025250/glycosylation-of-muc1-influences-the-binding-of-a-therapeutic-antibody-by-altering-the-conformational-equilibrium-of-the-antigen
#8
Mohammadreza Movahedin, Teresa M Brooks, Nitin T Supekar, Naveen Gokanapudi, Geert-Jan Boons, Cory L Brooks
In cancer cells, the glycoprotein Mucin 1 (MUC1) undergoes abnormal, truncated glycosylation. The truncated glycosylation exposes cryptic peptide epitopes that can be recognized by antibodies. Since these immunogenic regions are cancer specific, they represent ideal targets for therapeutic antibodies. We investigated the role of tumor-specific glycosylation on antigen recognition by the therapeutic antibody AR20.5. We explored the affinity of AR20.5 to a synthetic cancer-specific MUC1 glycopeptide and peptide...
December 26, 2016: Glycobiology
https://www.readbyqxmd.com/read/28012777/sequential-administration-of-a-mva-based-muc1-cancer-vaccine-and-the-tlr9-ligand-litenimod-li28-improves-local-immune-defense-against-tumors
#9
Emmanuelle Schaedler, Christelle Remy-Ziller, Julie Hortelano, Nadine Kehrer, Marie-Christine Claudepierre, Tanja Gatard, Christopher Jakobs, Xavier Préville, Antoine F Carpentier, Karola Rittner
TG4010 is an immunotherapeutic vaccine based on Modified Vaccinia virus Ankara (MVA) encoding the human tumor-associated antigen MUC1 and human IL-2. In combination with first-line standard of care chemotherapy in advanced metastatic non-small-cell lung cancer (NSCLC), repeated subcutaneous injection of TG4010 improved progression-free survival in phase 2b clinical trials. In preclinical tumor models, MVATG9931, the research version of TG4010, conferred antigen-specific responses against the weak antigen human MUC1...
December 21, 2016: Vaccine
https://www.readbyqxmd.com/read/28012230/targeting-muc1-and-jnk-by-rna-interference-and-inhibitor-inhibit-the-development-of-hepatocellular-carcinoma
#10
Juan Wang, Wei-Hua Ni, Ke-Bang Hu, Xiao-Yu Zhai, Fei Xie, Jing Jie, Nan-Nan Zhang, Li-Na Jiang, Hong-Yan Yuan, Gui-Xiang Tai
Mucin 1 (MUC1), as an oncogene, is overexpressed in hepatocellular carcinoma (HCC) cells and promotes the progression and tumorigenesis of HCC through JNK/TGF-β signaling pathway. In the present study, RNA interference (RNAi) and JNK inhibitor SP600125, which target MUC1 and/or JNK, were used to treat HCC cells in vitro, and the results showed that both silencing the expression of MUC1 and blocking the activity of JNK inhibited the proliferation of HCC cells. In addition, MUC1-stable-knockdown and SP600125 significantly inhibited the growth of tumors in the subcutaneous transplant tumor models that established in BALB/c nude mice rather than MUC1 or JNK siRNAs transiently transfection...
December 23, 2016: Cancer Science
https://www.readbyqxmd.com/read/28009531/effect-of-retinol-palmitate-on-corneal-and-conjunctival-mucin-gene-expression-in-a-rat-dry-eye-model-after-injury
#11
Nobuhito Tabuchi, Hiroshi Toshida, Daisuke Koike, Akito Odaka, Chikako Suto, Toshihiko Ohta, Akira Murakami
PURPOSE: We examined the wound-healing effect of retinol palmitate (VApal) on mucin gene and protein expressions in a rat dry eye model based on lacrimal gland (LG) resection after injury. METHODS: The rat dry eye model was prepared by surgical resection of the main LG in male Long-Evans rats. After alkaline injury of the central part of the lower palpebral conjunctiva bilaterally, VApal eye drops at 1,500 IU/mL in one eye and a vehicle in the fellow eye were both administered 6 times a day for 7 days...
January 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28004880/electrohydrodynamic-induced-sers-immunoassay-for-extensive-multiplexed-biomarker-sensing
#12
Khondakar Kamil Reza, Jing Wang, Ramanathan Vaidyanathan, Shuvashis Dey, Yuling Wang, Matt Trau
Cancer diagnosis and patient monitoring require sensitive and simultaneous measurement of multiple cancer biomarkers considering that single biomarker analysis present inadequate information on the underlying biological transformations. Thus, development of sensitive and selective assays for multiple biomarker detection might improve clinical diagnosis and expedite the treatment process. Herein, a microfluidic platform for the rapid, sensitive, and parallel detection of multiple cancer-specific protein biomarkers from complex biological samples is presented...
December 22, 2016: Small
https://www.readbyqxmd.com/read/27999702/serous-cystadenocarcinoma-arising-in-presumed-vitelline-duct-remnant-a-case-report-and-implications-in-the-management-of-cancer-of-unknown-primary
#13
Li Lei, Jeremy K Deisch
Background. Malignant neoplasms arising in Meckel's diverticulum, a vitelline duct remnant, are rare yet well-documented. Case Presentation. A 53-year-old previously healthy female presented with an enlarging midline abdominal wall mass. A computed tomography scan revealed a mass involving the linea alba, bilateral rectus abdominis, and subcutaneous fat. Extensive clinical workup failed to demonstrate other lesions, except local and paratracheal/hilar lymphadenopathy. Histopathologic examination of the resected tumor demonstrated a spectrum of serous neoplasia including serous cystadenoma, papillary serous carcinoma with numerous Psammoma bodies, and a poorly differentiated component...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27996167/intracellular-chloride-concentration-changes-modulate-il-1%C3%AE-expression-and-secretion-in-human-bronchial-epithelial-cultured-cells
#14
Mariángeles Clauzure, Ángel G Valdivieso, María M Massip-Copiz, Consuelo Mori, Andrea V Dugour, Juan M Figueroa, Tomás A Santa Coloma
Cystic fibrosis (CF) is caused by mutations in the CFTR gene, which encodes a cAMP-regulated chloride channel. Several cellular functions are altered in CF cells. However, it is not clear how the CFTR failure induces those alterations. We have found previously several genes differentially expressed in CF cells, including c-Src, MUC1, MTND4 and CISD1 (CFTR-dependent genes). Recently, we also reported the existence of several chloride-dependent genes, among them GLRX5 and RPS27. Here, varying the intracellular chloride concentration [Cl(-) ]i of IB3-1 CF bronchial epithelial cells, we show that IL-1β mRNA expression and secretion are also under Cl(-) modulation...
December 20, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27990353/effect-of-dihydrotestosterone-on-the-expression-of-mucin-1-and-the-activity-of-wnt-signaling-in-mouse-corneal-epithelial-cells
#15
Li Qin, Cheng Pei, Qian-Yan Kang, Zhao Liu, Li Li
AIM: To explore the effects of the androgen dihydrotestosterone on the expression of mucin 1 (MUC1) and the activity of Wnt signaling in mouse corneal epithelial cells. METHODS: Primary mouse corneal epithelial cells were isolated from the corneas of BALB/c mice. Quantitative real-time polymerase chain reaction, immunofluorescence and Western blot analysis were used to quantify the differential expression of selected genes. The androgen receptor was silenced by transfecting cells with androgen receptor shRNAs...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27989877/chinese-herbal-medicine-fuzheng-kang-ai-decoction-sensitized-the-effect-of-gefitinib-on-inhibition-of-human-lung-cancer-cells-through-inactivating-pi3-k-akt-mediated-suppressing-muc1-expression
#16
Longmei Li, SuMei Wang, Fang Zheng, WanYin Wu, Swei Sunny Hann
ETHNOPHARMACOLOGICAL RELEVANCE: Chinese herbal medicine (CHM) Fuzheng Kang-Ai (FZKA for short) decoction has been used as adjuvant treatment strategies in lung cancer patients for decades. However, the molecular mechanism underlying the therapeutic potential especially in sensitizing the effect of EGFR-TKI gefitinib has not been well elucidated. MATERIALS AND METHODS: Cell viability was detected by MTT assay. Cell cycle distribution was detected by flow cytometry...
October 28, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27989825/specific-targeting-delivery-to-muc1-overexpressing-tumors-by-albumin-chitosan-nanoparticles-conjugated-to-dna-aptamer
#17
Mehdi Esfandyari-Manesh, Ali Mohammadi, Fatemeh Atyabi, Seyedeh Maryam Nabavi, Seyedeh Masoumeh Ebrahimi, Elnaz Shahmoradi, Behrang Shiri Varnamkhasti, Mohammad Hossein Ghahremani, Rassoul Dinarvand
Chitosan-coated human serum albumin nanoparticles were functionalized by MUC1 aptamer to obtain a selective drug carrier toward cancers overexpressing MUC1. The negative charges of albumin nanoparticles were shifted to positive charges by surface modification with chitosan, and MUC1 was conjugated through an acrylate spacer. The cytotoxicity of targeted nanoparticles was significantly more than non-aptamer nanoparticles, and also the chitosan-coated nanoparticles had more cytotoxic effects than the negatively charged albumin nanoparticles...
October 28, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27984235/intraductal-tubulopapillary-neoplasm-of-the-pancreas-a-clinicopathologic-and-immunohistochemical-analysis-of-33-cases
#18
Olca Basturk, Volkan Adsay, Gokce Askan, Deepti Dhall, Giuseppe Zamboni, Michio Shimizu, Karina Cymes, Fatima Carneiro, Serdar Balci, Carlie Sigel, Michelle D Reid, Irene Esposito, Helena Baldaia, Peter Allen, Günter Klöppel, David S Klimstra
Intraductal tubulopapillary neoplasm (ITPN) is a relatively recently described member of the pancreatic intraductal neoplasm family. Thus, the literature on its histologic and immunohistochemical features, clinical behavior, and its similarities and differences from other pancreatic neoplasms is limited. Thirty-three cases of ITPN, the largest series to date, were identified. Immunohistochemical labeling for cytokeratins, glycoproteins, pancreatic enzymes, markers for intestinal and neuroendocrine differentiation, and antibodies associated with genetic alterations previously described in pancreatic neoplasms was performed...
December 14, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27983797/high-performance-ratiometric-electrochemical-method-based-on-the-combination-of-signal-probe-and-inner-reference-probe-in-one-hairpin-structured-dna
#19
Chunyan Deng, Xiaomei Pi, Pin Qian, Xiaoqing Chen, Wuming Wu, Juan Xiang
In this work, the dual signal-tagged hairpin structured DNA (dhDNA)-based ratiometric probe was developed by the combination of ferrocene-labeled signal probe (Fc-sP) and methylene blue-modified inner reference probe (MB-rP) in one hairpin-structured DNA. On the basis of this, a high-performance ratiometric electrochemical method was proposed for biomarker detection. In contrast to the conventional ratiometric electrochemical probe, this dhDNA ratiometric probe integrated sP and rP into one structure, which ensured the completely same modification condition and the interdependence of sP and rP on one sensing interface...
December 16, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27977898/expansion-of-divergent-sea-domains-in-cell-surface-proteins-and-nucleoporin-54
#20
Jimin Pei, Nick V Grishin
SEA (sea urchin sperm protein, enterokinase, agrin) domains, many of which possess autoproteolysis activity, have been found in a number of cell surface and secreted proteins. Despite high sequence divergence, SEA domains were also proposed to be present in dystroglycan based on a conserved autoproteolysis motif and receptor-type protein phosphatase IA-2 based on structural similarity. The presence of a SEA domain adjacent to the transmembrane segment appears to be a recurring scheme in quite a number of type I transmembrane proteins on the cell surface, such as MUC1, dystroglycan, IA-2, and Notch receptors...
December 15, 2016: Protein Science: a Publication of the Protein Society
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