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JOURNAL ARTICLE
Tjeerd Pieter van Staa, Alexander Pate, Glen P Martin, Anita Sharma, Paul Dark, Tim Felton, Xiaomin Zhong, Sian Bladon, Neil Cunningham, Ellie L Gilham, Colin S Brown, Mariyam Mirfenderesky, Victoria Palin, Diane Ashiru-Oredope
PURPOSE: Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection. The purpose of the study was to measure the associations of specific exposures (deprivation, ethnicity, and clinical characteristics) with incident sepsis and case fatality. METHODS: Two research databases in England were used including anonymized patient-level records from primary care linked to hospital admission, death certificate, and small-area deprivation...
April 16, 2024: Infection
#2
JOURNAL ARTICLE
Austin T Bond, Yasmine S Soubra, Umaymah Aziz, Andrew M Read-Fuller, Likith V Reddy, Matthew J Kesterke, Dina Amin
BACKGROUND: Quick Sequential Organ Failure Assessment (qSOFA) is recommended to identify sepsis. Odontogenic infection (OI) can progress to sepsis, causing systematic inflammatory complications or organ failure. PURPOSE: The purpose of the study was to measure the association/s between OI location and risk for sepsis at admission. STUDY DESIGN, SETTING, AND SAMPLE: This retrospective cohort study included subjects treated for OI at Baylor University Medical Center in Dallas, TX, from January 9, 2019 to July 30, 2022...
March 28, 2024: Journal of Oral and Maxillofacial Surgery
#3
JOURNAL ARTICLE
Evelyn Yi Wen Chau, Afliza Abu Bakar, Aireen Binti Zamhot, Ida Zarina Zaini, Siti Norafida Binti Adanan, Dazlin Masdiana Binti Sabardin
BACKGROUND: The latest Surviving Sepsis Campaign 2021 recommends early antibiotics administration. However, Emergency Department (ED) overcrowding can delay sepsis management. This study aimed to determine the effect of ED overcrowding towards the management and outcome of sepsis patients presented to ED. METHODS: This was an observational study conducted among sepsis patients presented to ED of a tertiary university hospital from 18th January 2021 until 28th February 2021...
April 12, 2024: BMC Emergency Medicine
#4
JOURNAL ARTICLE
Surichhya Bajracharya, Preetha Prazad, Catherine Bennett, Nahren Asado
PURPOSE: Our quality improvement study aimed to determine whether application of a neonatal early-onset sepsis calculator (NSC) among well-appearing infants born at ≥35 weeks' gestation to mothers with chorioamnionitis decreases the number of lab evaluations (LEs) and antibiotic treatments (Abxs) without missing early-onset sepsis. METHODS: We compared 2 years (January 1, 2019-January 3, 2021) of data from a historical-control group before implementation of the NSC to 1 year (January 4, 2021-December 31, 2021) of data from a calculator group after implementation of the NSC to evaluate whether LE and Abx decreased following implementation of the NSC on January 4, 2021...
2024: Journal of Patient-centered Research and Reviews
#5
JOURNAL ARTICLE
Priya A Prasad, Armond M Esmaili, Sandra Oreper, Alexander J Beagle, Colin Hubbard, Katie E Raffel, Yumiko Abe-Jones, Margaret C Fang, Kathleen D Liu, Michael A Matthay, Kirsten N Kangelaris
OBJECTIVE: Recent clinical guidelines for sepsis management emphasize immediate antibiotic initiation for suspected septic shock. Though hypotension is a high-risk marker of sepsis severity, prior studies have not considered the precise timing of hypotension in relation to antibiotic initiation and how clinical characteristics and outcomes may differ. Our objective was to evaluate antibiotic initiation in relation to hypotension to characterize differences in sepsis presentation and outcomes in patients with suspected septic shock...
April 2024: Journal of the American College of Emergency Physicians open
#6
JOURNAL ARTICLE
Juan Ouyang, Lihe Sun, Zunpan She, Rong Li, Fang Zeng, Zhicheng Yao, Shuizhu Wu
Wounds infected with bacteria, if left untreated, have the potential to escalate into life-threatening conditions, such as sepsis, which is characterized by widespread inflammation and organ damage. A comprehensive approach to treating bacterial-infected wounds, encompassing the control of bacterial infection, biofilm eradication, and inflammation regulation, holds significant importance. Herein, a microneedle (MN) patch ( FM@ST MN ) has been developed, with silk fibroin (SF) and tannic acid-based hydrogel serving as the matrix...
April 9, 2024: ACS Applied Materials & Interfaces
#7
Jia Ying Tan, Guo Nian Teo, Ethan Ng, Andrew Ban Guan Tay, John Rong Hao Tay
Background : There have been no reports of sepsis-induced agranulocytosis causing gingival necrosis in otherwise medically healthy patients to the authors' best knowledge. Even though there are several case reports of gingival necrosis secondary to medication-induced agranulocytosis, they have not systematically described the natural progression of agranulocytosis-related gingival necrosis. Methods : This paper presents a case report of a 29-year-old female Indian patient with generalised gingival necrosis and constitutive signs of intermittent fever, nausea, and vomiting...
February 24, 2024: Journal of Clinical Medicine
#8
REVIEW
Zoran Matkovic, Zoran Aleksic
BACKGROUND: Acute mesenteric ishemia(AMI) is a rare but very serious disease with high rate of mortality and morbidity. About 1-2% of all gastrointestinal disease is AMI. Mortality is about 60-80% and depends of time between starting of symptoms and establishing of diagnosis, type AMI, comorbidities. AMI is often in older population with coronary syndrom and atrial fibrilation. AMI may be occlusive(embolisatio arteriae mesentericae superior(AMS), or thrombosis of AMS, mesenterial vein thrombosis) and nonoclusive form(NOMI)...
2024: Materia Socio-medica
#9
JOURNAL ARTICLE
Divya Jain, Somanath Malage, Ashish Singh, Nalinikanta Ghosh, Rahul Rahul, Supriya Sharma, Ashok Kumar, Rajneesh K Singh, Anu Behari, Ashok Kumar, Rajan Saxena
Background Postcholecystectomy bile duct injury (BDI) is a management challenge with significant morbidity, mortality, and effects on long-term quality of life. Early referral to a specialized hepatobiliary center and appropriate early management are crucial to improving outcomes and overall quality of life. In this retrospective analysis, we examined patients who were managed at our center over the past 10 years and proposed a triage and management algorithm for BDI in acute settings. Methods Patients referred to our center with BDI from January 2011 to December 2020 were reviewed retrospectively...
March 2024: Curēus
#10
Rahul Ranjan, Ankita Rai, Pooja Pandey, Raunak Bir, Priti Agarwal
Listeria monocytogenes , a gram-positive bacillus and an intracellular pathogen, is an uncommon cause of illness in the general population. During pregnancy, a perinatal infection can lead to serious complications such as abortion, stillbirth, neonatal sepsis, and meningitis. We present two cases of neonatal meningitis caused by Christie, Atkins, Munch-Peterson (CAMP)-negative Listeria monocytogenes . In the first case, a seven-day-old female term neonate delivered vaginally, presented with high-grade fever and refusal to feed...
March 2024: Curēus
#11
JOURNAL ARTICLE
Gakuto Ujiie, Masahiko Murase, Hideyuki Asai, Mio Igawa, Ayumi Okuyama, Kohei Seo, Kiyotake Ichizuka, Hirokazu Ikeda
AIM: To compare the prophylactic efficacy of ampicillin and clindamycin against vertical transmission of group B Streptococcus from mothers to their infants by evaluating the rates of group B Streptococcus colonisation. METHODS: We retrospectively extracted data for mothers who delivered at Showa University Northern Yokohama Hospital between 1 October 2017 and 31 March 2021 and tested positive for antepartum group B Streptococcus, and their infants. The chi-square test was used to compare the rates of group B Streptococcus colonisation, sepsis, and meningitis...
April 5, 2024: Acta Paediatrica
#12
JOURNAL ARTICLE
Jie Li, Ning Han, Yangyang Li, Feifei Zhao, Wenguang Xiong, Zhenling Zeng
BACKGROUND: The rapid spread of bacteria with plasmid-mediated resistance to antibiotics poses a serious threat to public health. The search for potential compounds that can increase the antibacterial activity of existing antibiotics is a promising strategy for addressing this issue. METHODS: Synergistic activity of the FDA-approved agent oxethazine combined with colistin was investigated in vitro using checkerboard assays and time-kill curves. The synergistic mechanisms of their combination of oxethazine and colistin was explored by fluorescent dye, scanning electron microscopy (SEM) and LC-MS/MS...
2024: Frontiers in Pharmacology
#13
JOURNAL ARTICLE
Sherry L Kausch, Douglas E Lake, Juliann M Di Fiore, Debra E Weese-Mayer, Nelson Claure, Namasivayam Ambalavanan, Zachary A Vesoulis, Karen D Fairchild, Phyllis A Dennery, Anna Maria Hibbs, Richard J Martin, Indic Premananda, Colm P Travers, Eduardo Bancalari, Aaron Hamvas, James S Kemp, John L Carroll, J Randall Moorman, Brynne A Sullivan
OBJECTIVE: To examine the association of cardiorespiratory events, including apnea, periodic breathing, intermittent hypoxemia (IH), and bradycardia, with late-onset sepsis for extremely preterm infants (<29 weeks' gestational age [GA]) on versus off invasive mechanical ventilation. STUDY DESIGN: This is a retrospective analysis of data from infants enrolled in Pre-Vent (ClinicalTrials.gov identifier NCT03174301), an observational study in five level IV neonatal intensive care units...
April 1, 2024: Journal of Pediatrics
#14
JOURNAL ARTICLE
Eugene Yeung, Nadia Sant, Ewa Sucha, Reza Belaghi, Nicole Le Saux
BACKGROUND: Knowledge of time to positivity (TTP) for blood cultures is useful to assess timing of discontinuation of empiric antimicrobials for suspected bacteremia with no focus. METHODS: An audit of positive blood cultures from the Children's Hospital of Eastern Ontario (CHEO) from November 1, 2019, to October 31, 2020, was performed to determine TTP, defined as the start of incubation to a positive signal from automated incubators. RESULTS: Three hundred seventy-six positive blood cultures were identified from 248 patients (average age: 6...
March 2024: Journal of the Association of Medical Microbiology and Infectious Disease Canada, Journal officiel de l’Association pour la microbiologie médicale et l’infectiologie Canada
#15
Beatriz Câmara, Catarina Andrade, Andreia Forno, Marta Lopes, Carla Pilar
Neck stiffness is a common clinical sign in children presenting to the emergency department that may indicate a wide variety of diagnoses. Acute suppurative thyroiditis (AST) is an infection of the thyroid gland caused by a bacterium, virus, or, less commonly, fungus. It presents as an acute or subacute development of an anterior cervical mass, with associated inflammatory signs. The pressure upon neck muscles may be reflected as a limitation of cervical mobility. AST is often preceded by an upper respiratory tract infection, and pyriform sinus fistula is the most common predisposing factor...
February 2024: Curēus
#16
JOURNAL ARTICLE
Maria Nieto-Rosado, Kirsty Sands, Edward A R Portal, Kathryn M Thomson, Maria J Carvalho, Jordan Mathias, Rebecca Milton, Calie Dyer, Chinenye Akpulu, Ian Boostrom, Patrick Hogan, Habiba Saif, Ana D Sanches Ferreira, Thomas Hender, Barbra Portal, Robert Andrews, W John Watkins, Rabaab Zahra, Haider Shirazi, Adil Muhammad, Syed Najeeb Ullah, Muhammad Hilal Jan, Shermeen Akif, Kenneth C Iregbu, Fatima Modibbo, Stella Uwaezuoke, Lamidi Audu, Chinago P Edwin, Ashiru H Yusuf, Adeola Adeleye, Aisha S Mukkadas, Jean Baptiste Mazarati, Aniceth Rucogoza, Lucie Gaju, Shaheen Mehtar, Andrew N H Bulabula, Andrew Whitelaw, Lauren Roberts, Grace Chan, Delayehu Bekele, Semaria Solomon, Mahlet Abayneh, Gesit Metaferia, Timothy R Walsh
Hospital surfaces can harbour bacterial pathogens, which may disseminate and cause nosocomial infections, contributing towards mortality in low- and middle-income countries (LMICs). During the BARNARDS study, hospital surfaces from neonatal wards were sampled to assess the degree of environmental surface and patient care equipment colonisation by Gram-negative bacteria (GNB) carrying antibiotic resistance genes (ARGs). Here, we perform PCR screening for extended-spectrum β-lactamases (blaCTX-M-15 ) and carbapenemases (blaNDM , blaOXA-48 -like and blaKPC ), MALDI-TOF MS identification of GNB carrying ARGs, and further analysis by whole genome sequencing of bacterial isolates...
March 29, 2024: Nature Communications
#17
JOURNAL ARTICLE
Ali Alipouriani, Tracy Hull, Jeremy Lipman, Stefan D Holubar, Emre Gorgun, David Liska, Michael Valente, Scott R Steele
BACKGROUND: Ileal pouch-anal anastomosis (IPAA) is considered the preferred restorative surgical procedure for patients with ulcerative colitis and familial adenomatous polyposis requiring proctocolectomy. Unfortunately, postoperative leaks remain a complication with potentially significant ramifications. This study aimed to provide a comprehensive description of the evaluation, management, and outcomes of leaks after primary IPAA procedures. METHODS: Between 1995 and 2022, a total of 4058 primary IPAA procedures were performed at Cleveland Clinic...
March 16, 2024: Journal of Gastrointestinal Surgery
#18
JOURNAL ARTICLE
Michaël Levy, Renaud Blondé, Jérôme Naudin, Stéphane Dauger
PEDIATRIC NECROTIZING SOFT-TISSUE INFECTIONS. Necrotizing soft-tissue infections (NSTI) include necrotizing forms of fasciitis, myositis, and cellulitis. In children, these are extremely rare conditions with an estimated annual incidence of less than 0.1/100,000 patients aged 0-18 years in France. Nevertheless, the evolution can be very serious (6% mortality, higher than the mortality observed in paediatric intensive care units [PICU]), whereas the initial local symptoms are poor and can be falsely reassuring...
March 2024: La Revue du Praticien
#19
JOURNAL ARTICLE
W P Lin, X Mu, S H Chen, C J He, H H Li, C W Sun, H N Bian, W Lai, Z F Huang
Objective: To analyze the clinical characteristics of patients with Vibrio vulnificus infection, share diagnosis and treatment experience, and establish a rapid diagnosis procedure for this disease. Methods: This study was a retrospective case series study. From January 2009 to November 2022, 11 patients with Vibrio vulnificus infection who met the inclusion criteria were admitted to the Department of Burns and Wound Repair of Guangdong Provincial People's Hospital Affiliated to Southern Medical University...
March 20, 2024: Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi
#20
JOURNAL ARTICLE
Muhammad Haris Khan, Muhammad Adnan Wattoo, Habib Ur Rehman Butt, Muhammad Zaid, Umair Tahir, Mehwish Kaneez, Usaid Munir Joyia, Syed Faheem Bukhari
Background Acute leukemia, characterized by the uncontrolled proliferation of immature white blood cell precursors, poses significant challenges during induction chemotherapy, including the elevated risk of febrile neutropenia and its associated complications. Our study aims to explain the clinical and etiological parameters of these patients in a resource-limited setting. Methods This retrospective study focused on a total of 102 adult patients with acute leukemia who developed febrile neutropenia during the induction chemotherapy phase...
February 2024: Curēus
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