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https://www.readbyqxmd.com/read/28625639/longitudinal-monitoring-of-ctdna-egfr-mutation-burden-from-urine-correlates-with-patient-response-to-egfr-tkis-a-case-series
#1
Nishan Tchekmedyian, Raja Mudad, Fernando F Blanco, Victoria M Raymond, Jordan Garst, Mark G Erlander, Eric Haura, David Berz
Targetable, somatic EGFR mutations are highly prevalent in patients with non-small cell lung cancer (NSCLC), making them eligible for tyrosine kinase inhibitor (TKI) therapy. Circulating tumor DNA (ctDNA), isolated from blood or urine, has been demonstrated to reliably identify somatic tumor associated EGFR mutations, specifically in patients with inconclusive biopsy. When conventional imaging modalities are inconclusive, quantitative assessment of systemic ctDNA burden has the potential to assess therapeutic response...
June 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28615714/platelet-distribution-width-correlates-with-prognosis-of-non-small-cell-lung-cancer
#2
Ming-Ming Cui, Na Li, Xing Liu, Zhi-Yuan Yun, Ye Niu, Yong Zhang, Boning Gao, Tiemin Liu, Rui-Tao Wang
Platelets play a multifaceted role in cancer progression and metastasis. Mean platelet volume (MPV) and platelet distribution width (PDW) are commonly used platelet parameters from routine blood test. The aim of the present study was to investigate the correlation between platelet indices and prognosis in patients with non-small cell lung cancer (NSCLC). A total of 270 patients who were diagnosed with NSCLC between January 2009 and December 2009 were retrospectively analyzed. Patients' characteristics and hematologic tests data at initial diagnosis were collected...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28615231/single-nucleotide-polymorphism-leading-to-false-allelic-fraction-by-droplet-digital-pcr
#3
Eric S Christenson, William B Dalton, David Chu, Ian Waters, Karen Cravero, Daniel J Zabransky, Amy DeZern, Ben Ho Park
BACKGROUND: Molecular-based diagnostics have great utility for cancer detection. We have used droplet digital PCR (ddPCR) as a platform for identifying mutations in circulating plasma tumor DNA (ptDNA). We present the unexpected finding of a spurious mutant allele fraction that was discovered to be artifactual because of the presence of a single-nucleotide polymorphism (SNP) in a patient sample. DESIGN AND METHODS: Probe and primer combinations for the K700 and V701 loci of the SF3B1 spliceosome gene were designed for ddPCR to identify the percentage of mutant and wild-type alleles...
June 14, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28609695/what-do-we-need-to-make-circulating-tumour-dna-ctdna-a-routine-diagnostic-test-in-lung-cancer
#4
REVIEW
Reyes Bernabé, Nicholas Hickson, Andrew Wallace, Fiona Helen Blackhall
The gold standard test for detection of epidermal growth factor receptor (EGFR) mutation is to genotype somatic DNA extracted from a tissue biopsy or cytology specimen. Yet, in at least 20% of patients this is not possible for various reasons including insufficient availability of neoplastic tissue, lack of fitness of the available tissue for a biopsy or that a biopsy is not technically feasible. Consequently, there has been intense investigation of circulating tumour DNA (ctDNA), released into the plasma fraction of blood from cancer cells during apoptosis/necrosis, as a minimally invasive 'liquid biopsy' and surrogate for cancer tissue...
June 10, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28607762/can-visual-assessment-of-blood-flow-patterns-by-dynamic-contrast-enhanced-computed-tomography-distinguish-between-malignant-and-benign-lung-tumors
#5
Stefan Walbom Harders, Hans Henrik Madsen, Hanne Marie Nellemann, Torben Riis Rasmussen, Jesper Thygesen, Henrik Hager, Niels Trolle Andersen, Finn Rasmussen
BACKGROUND: Dynamic contrast-enhanced computed tomography (DCE-CT) is a tool, which, in theory, can quantify the blood flow and blood volume of tissues. In structured qualitative analysis, parametric color maps yield a visual impression of the blood flow and blood volume within the tissue being studied, allowing for quick identification of the areas with the highest or lowest blood flow and blood volume. PURPOSE: To examine whether DCE-CT could be used to distinguish between malignant and benign lung tumors in patients with suspected lung cancer...
May 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28599429/disseminated-carcinomatosis-of-the-bone-marrow-with-disseminated-intravascular-coagulation-as-the-first-symptom-of-recurrent-rectal-cancer-successfully-treated-with-chemotherapy-a-case-report-and-review-of-the-literature
#6
Hiroshi Takeyama, Tsutomu Sakiyama, Tomoko Wakasa, Kotaro Kitani, Keisuke Inoue, Hiroaki Kato, Shinya Ueda, Masanori Tsujie, Yoshinori Fujiwara, Masao Yukawa, Yoshio Ohta, Masatoshi Inoue
Disseminated carcinomatosis of the bone marrow (DCBM) is a condition in which bone marrow (BM) metastases diffusely invade the BM, and is frequently accompanied by disseminated intravascular coagulation (DIC). While prostate, lung, breast and stomach malignancies, in addition to neuroblastoma, are the most prevalent non-hematological malignancies to metastasize frequently to the BM, colorectal cancer is a malignancy that rarely metastasizes to the BM. The present case describes a 65-year-old male patient treated by resection and one course adjuvant chemotherapy for stage IIIC rectal cancer who presented with nasal bleeding at 8 months post-surgery...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28583629/evaluation-of-postoperative-lung-volume-and-perfusion-changes-by-dual-energy-computed-tomography-in-patients-with-lung-cancer
#7
Jooae Choe, Sang Min Lee, Eun Jin Chae, Sang Min Lee, Yong-Hee Kim, Namkug Kim, Joon Beom Seo
PURPOSE: The aim of our study was to retrospectively evaluate postoperative physiologic changes in lung cancer patients using dual-energy CT (DECT), and develop modified methods reflecting postoperative change for predicting pulmonary function. METHODS AND MATERIALS: 88 patients (M:F=64:24; mean age, 63.5 years) with lung cancer who underwent DECT and pulmonary function tests before and after operation were included. Volume and iodine values for perfusion of each lobe were quantified...
May 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28576594/time-and-effort-required-for-tissue-acquisition-and-submission-in-lung-cancer-clinical-trials
#8
Sandra Garcia, Jessica M Saltarski, Jingsheng Yan, Xian-Jin Xie, David E Gerber
BACKGROUND: Increasingly, analysis of tumor tissue samples for predictive and pharmacodynamic biomarkers is incorporated into lung cancer clinical trials. We determined the time and effort required for tissue acquisition and submission. PATIENTS AND METHODS: We analyzed data from patients enrolled from 2009 to 2016 at UT Southwestern onto lung cancer trials with mandatory or optional submission of tumor tissue. We collected dates of treatment-related events and staff communications; nature of tissue requirement and biomarker analysis; and location of archival tissue...
May 8, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28566081/-a-rarely-isolated-bacterium-in-microbiology-laboratories-streptococcus-uberis
#9
Canan Eryıldız, Şebnem Bukavaz, Şaban Gürcan, Osman Hatipoğlu
Streptococcus uberis is a gram-positive bacterium that is mostly responsible for mastitis in cattle. The bacterium rarely has been associated with human infections. Conventional phenotyphic methods can be inadequate for the identification of S.uberis; and in microbiology laboratories S.uberis is confused with the other streptococci and enterococci isolates. Recently, molecular methods are recommended for the accurate identification of S.uberis isolates. The aim of this report is to present a lower respiratory tract infection case caused by S...
April 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28546320/a-cohort-mortality-study-of-lead-exposed-workers-in-the-usa-finland-and-the-uk
#10
Kyle Steenland, Vaughn Barry, Ahti Anttila, Markku Sallmén, Damien McElvenny, A C Todd, Kurt Straif
OBJECTIVES: To investigate further whether inorganic lead is a carcinogen among adults, or associated with increased blood pressure and kidney damage, via a large mortality study. METHODS: We conducted internal analyses via Cox regression of mortality in three cohorts of lead-exposed workers with blood lead (BL) data (USA, Finland, UK), including over 88 000 workers and over 14 000 deaths. Our exposure metric was maximum BL. We also conducted external analyses using country-specific background rates...
May 25, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28544400/elevated-pretreatment-neutrophil-white-blood-cell-ratio-and-monocyte-lymphocyte-ratio-predict-poor-survival-in-patients-with-curatively-resected-non-small-cell-lung-cancer-results-from-a-large-cohort
#11
Cheng Yuan, Ning Li, Xiaoyong Mao, Zui Liu, Wei Ou, Si-Yu Wang
BACKGROUND: The prognostic values of preoperative neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), and platelet/lymphocyte ratio (PLR) in non-small cell lung cancer (NSCLC) have been previously described. This study assessed the prognostic values of other pretreatment complete blood cell parameters in Chinese patients with curatively resected NSCLC. METHODS: A total of 1466 consecutive NSCLC patients who received curative surgery from January 1, 2005 to December 31, 2009 with complete data from pretreatment blood tests were enrolled in this retrospective study...
May 22, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28542283/shared-susceptibility-loci-at-2q33-region-for-lung-and-esophageal-cancers-in-high-incidence-areas-of-esophageal-cancer-in-northern-china
#12
Xue Ke Zhao, Yi Min Mao, Hui Meng, Xin Song, Shou Jia Hu, Shuang Lv, Rang Cheng, Tang Juan Zhang, Xue Na Han, Jing Li Ren, Yi Jun Qi, Li Dong Wang
BACKGROUND: Cancers from lung and esophagus are the leading causes of cancer-related deaths in China and share many similarities in terms of histological type, risk factors and genetic variants. Recent genome-wide association studies (GWAS) in Chinese esophageal cancer patients have demonstrated six high-risk candidate single nucleotide polymorphisms (SNPs). Thus, the present study aimed to determine the risk of these SNPs predisposing to lung cancer in Chinese population. METHODS: A total of 1170 lung cancer patients and 1530 normal subjects were enrolled in this study from high-incidence areas for esophageal cancer in Henan, northern China...
2017: PloS One
https://www.readbyqxmd.com/read/28533476/neutrophil-lymphocyte-ratio-is-a-prognostic-marker-in-patients-with-locally-advanced-stage-iiia-and-iiib-non-small-cell-lung-cancer-treated-with-combined-modality-therapy
#13
Katherine A Scilla, Søren M Bentzen, Vincent K Lam, Pranshu Mohindra, Elizabeth M Nichols, Melissa A Vyfhuis, Neha Bhooshan, Steven J Feigenberg, Martin J Edelman, Josephine L Feliciano
BACKGROUND: Neutrophil-lymphocyte ratio (NLR) is a measure of systemic inflammation that appears prognostic in localized and advanced non-small cell lung cancer (NSCLC). Increased systemic inflammation portends a poorer prognosis in cancer patients. We hypothesized that low NLR at diagnosis is associated with improved overall survival (OS) in locally advanced NSCLC (LANSCLC) patients. PATIENTS AND METHODS: Records from 276 patients with stage IIIA and IIIB NSCLC treated with definitive chemoradiation with or without surgery between 2000 and 2010 with adequate data were retrospectively reviewed...
June 2017: Oncologist
https://www.readbyqxmd.com/read/28530534/biological-evaluation-of-99mtc-hynic-edda-tricine-ser-3-d4-peptide-for-tumor-targeting
#14
Ziba Kazemi, Mona Haddad Zahmatkesh, Seyed Mohammad Abedi, Seyed Jalal Hosseinimehr
BACKGROUND: D4 small peptide (Leu-Ala-Arg-Leu-Leu-Thr) was selected as an appropriate agent for specific targeting of epidermal growth factor receptor (EGFR). OBJECTIVE: The aim of study was to investigate the 99mTc-labeled D4 peptide for non small cell lung tumor targeting. METHOD: HYNIC-(Ser)3-D4 peptide was labeled with 99mTc using mixture of tricine and ethylenediamine diacetic acid (EDDA) as co-ligands. The in vitro cellular uptake of radiolabebled peptide was evaluated by blocking test on human non small lung cancer (A-549) cell line and its biodistribution was evaluated in A-549 xenografted nude mice...
May 19, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28523317/mri-as-indicator-of-pulmonary-tuberculosis-activity-from-morphological-to-molecular-level-assessment-a-case-report
#15
Maria Teodora Antuaneta Buzan, Hanelore Herta, Mihaela Maria Coman, Daniela Homorodean, Silviu Andrei Sfrângeu, Carmen Monica Pop
We present the case of an adult patient with active post-primary pulmonary tuberculosis (TB) and discuss specific morphological and textural aspects found at high-field magnetic resonance imaging (MRI) of the lung. The 42-year-old man, heavy smoker, undertook a routine employment medical examination and was admitted to a referral pulmonology and TB center due to the abnormal findings seen on his chest radiography. The patient presented nonspecific symptoms, bilateral bronchial breath at pulmonary auscultation, inflammatory syndrome on the laboratory blood tests and positive sputum smears for acid-fast bacilli, which together with the typical aspect on the chest radiography lead to a diagnosis of post-primary pulmonary TB and administration of specific medication...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28515940/nivolumab-induced-autoimmune-diabetes-mellitus-presenting-as-diabetic-ketoacidosis-in-a-patient-with-metastatic-lung-cancer
#16
James Luke Godwin, Shuchie Jaggi, Imali Sirisena, Pankaj Sharda, Ajay D Rao, Ranee Mehra, Colleen Veloski
BACKGROUND: Advances in cancer immunotherapy have generated encouraging results in multiple malignancies refractory to standard chemotherapies. As the use of immune checkpoint inhibitors (ICI) proliferates, the incidence of autoimmune side effects associated with these agents, termed immune related adverse events (irAE), is expected to increase. The frequency of significant irAE in ICI treated patients is about 10-20% and early recognition is critical to prevent serious morbidity and even mortality...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28500316/establishment-of-a-strong-link-between-smoking-and-cancer-pathogenesis-through-dna-methylation-analysis
#17
Yunlong Ma, Ming D Li
Smoking is a well-documented risk factor in various cancers, especially lung cancer. In the current study, we tested the hypothesis that abnormal DNAm loci associated with smoking are enriched in genes and pathways that convey a risk of cancer by determining whether smoking-related methylated genes led to enrichment in cancer-related pathways. We analyzed two sets of smoking-related methylated genes from 28 studies originating from blood and buccal samples. By analyzing 320 methylated genes from 26 studies on blood samples (N = 17,675), we found 57 enriched pathways associated with different types of cancer (FDR < 0...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28499267/a-novel-germline-tp53-mutation-p-pro190arg-detected-in-a-patient-with-lung-and-bilateral-breast-cancers
#18
Małgorzata Krześniak, Dorota Butkiewicz, Jadwiga Rachtan, Iwona Matuszczyk, Ewa Grzybowska, Marek Rusin
PURPOSE: Li-Fraumeni syndrome (LFS) is a rare genetic disease with strong predispositions to multiple early-onset neoplasms, mostly sarcomas, breast cancers, brain tumors and adrenocortical carcinomas (LFS core cancers). In most LFS families the germline mutations of TP53 tumor suppressor gene were found. Lung cancer does not belong to the core cancers of LFS, however its higher incidence is observed in families with TP53 mutations. Our aim was to search for TP53 mutations in female lung cancer patients whose clinico-demographic characteristics suggested a probable genetic predisposition to the disease...
May 9, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28480046/steroid-induced-tumour-lysis-syndrome-in-small-cell-lung-cancer
#19
Fasihul Khan, Shazeen Ayub, Qurrat Mehmood, Syed Fayyaz Hussain
A 64-year-old male presented to hospital with breathlessness and weight loss. Ultrasound-guided biopsy of supraclavicular lymph node confirmed a diagnosis of small-cell lung cancer. The patient was started on Dexamethasone 8 mg twice daily for symptom control while awaiting urgent oncology assessment. Three days later he was admitted with acute kidney injury and worsening breathlessness. Biochemical changes confirmed tumour lysis syndrome (TLS) that had occurred following steroid therapy. He was given allopurinol followed by rasburicase...
May 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28463958/prospective-study-of-dna-methylation-at-chromosome-8q24-in-peripheral-blood-and-prostate-cancer-risk
#20
Kathryn Hughes Barry, Lee E Moore, Joshua N Sampson, Stella Koutros, Liying Yan, Ann Meyer, Mahitha Reddy, Andrew J Oler, Michael B Cook, Joseph F Fraumeni, Meredith Yeager, Laufey T Amundadottir, Sonja I Berndt
BACKGROUND: Chromosome 8q24 has emerged as an important genetic susceptibility region for several cancers, including prostate cancer; however, little is known about the contribution of DNA methylation in this region to risk. METHODS: We prospectively evaluated DNA methylation at 8q24 in relation to prostate cancer using pre-diagnostic blood samples from 694 prostate cancer cases (including 172 aggressive cases) and 703 controls in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial...
May 23, 2017: British Journal of Cancer
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