Roel Vermeulen, Barbara Bodinier, Sonia Dagnino, Rin Wada, Xuting Wang, Debra Silverman, Demetrius Albanes, Neal Freedman, Mohammad Rahman, Douglas Bell, Marc Chadeau-Hyam, Nathaniel Rothman
Bladder cancer, a common neoplasm, is primarily caused by tobacco smoking. Epigenetic alterations including DNA methylation have the potential to be used as prospective markers of increased risk, particularly in at-risk populations such as smokers. We aimed to investigate the potential of smoking-related white blood cell (WBC) methylation markers to contribute to an increase in bladder cancer risk prediction over classical questionnaire-based smoking metrics (i.e., duration, intensity, packyears) in a nested case-control study within the prospective prostate, lung, colorectal, and ovarian (PLCO) Cancer Screening Trial and the alpha-tocopherol, beta-carotene cancer (ATBC) Prevention Study (789 cases; 849 controls)...
March 30, 2024: European Journal of Epidemiology