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Colorectal cancer blood tests

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https://www.readbyqxmd.com/read/29166546/back-to-back-colon-capsule-endoscopy-and-optical-colonoscopy-in-colorectal-cancer-screening-individuals
#1
Morten Kobaek-Larsen, Rasmus Kroijer, Anne-Kirstine Dyrvig, Maria Magdalena Buijs, Robert J C Steele, Niels Qvist, Gunnar Baatrup
AIM: To determine the polyp detection rate and per-patient sensitivity for polyps >9 mm of colon capsule endoscopy (CCE) compared with colonoscopy as well as the diagnostic accuracy of CCE. METHOD: Individuals who had positive immunochemical faecal occult blood test during screening had investigator blinded colon capsule endoscopy and colonoscopy. Participants underwent repeat endoscopy if significant lesions detected by colon capsule endoscopy were considered to have been missed by colonoscopy...
November 22, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29147109/colorectal-cancer-blood-based-biomarkers
#2
REVIEW
Nina Hauptman, Damjan Glavač
Mortality and morbidity associated with colorectal cancer (CRC) are increasing globally, partly due to lack of early detection of the disease. The screening is usually performed with colonoscopy, which is invasive and unpleasant, discouraging participation in the screening. As a source of noninvasive and easily accessible biomarkers, liquid biopsies are emerging. Blood-based biomarkers have the potential as diagnostic and prognostic tool in CRC. Early stage detection of CRC with high sensitivity and specificity would likely lead to higher participation in the screening test...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29142905/p-cadherin-cdh3-is-overexpressed-in-colorectal-tumors-and-has-potential-as-a-serum-marker-for-colorectal-cancer-monitoring
#3
H M C Shantha Kumara, Geoffrey A Bellini, Otavia L Caballero, Sonali A C Herath, Tao Su, Aqeel Ahmed, Linda Njoh, Vesna Cekic, Richard L Whelan
Introduction: Placental-Cadherin (CDH3) is a cell adhesion molecule vital to cellular localization and tissue integrity. It is highly expressed in the placenta (PLC)and is overexpressed by many types of cancer. P-cadherin levels in colorectal cancer (CRC) remains poorly characterized. This study's purpose was to determine P-cadherin expression in CRC and normal tissues and to assess plasma CDH3 levels in order to determine the relationship, if any, between cancer stage, P-cadherin expression and plasma CDH3 levels...
September 2017: Oncoscience
https://www.readbyqxmd.com/read/29142410/methanolic-extract-of-costus-pictus-d-don-induces-cytotoxicity-in-liver-hepatocellular-carcinoma-cells-mediated-by-histone-deacetylase-inhibition
#4
P V Neethu, K Suthindhiran, M A Jayasri
Background: Leaves of Costus pictus D. Don, (insulin plant) are used as dietary supplement for the treatment of diabetes. Objective: The antidiabetic activity of this plant is well documented, but its activity on different cell types and mechanism remains unknown. Thus, the present study evaluates the cytotoxicity of C. pictus methanolic extract (CPME) against various cancer and normal cells. Materials and Methods: Dried leaves of C. pictus were extracted using methanol and were subjected to histone deacetylase (HDAC) inhibition and toxicity studies...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29136732/-prognosis-factors-for-the-perineal-incision-complications-after-abdominoperineal-resection-for-low-rectal-cancer
#5
S Luo, J W Liang, H T Zhou, W Pei, Z X Zhou, Q Liu, X S Wang
Objective: To evaluate the prognosis factors affecting perineal incision complications after abdominoperineal resection (APR) for the low rectal cancer. Methods: This was a retrospective analysis of 151 consecutive patients with low rectal cancer undergoing APR between January and December 2013 at Department of Colorectal Surgery, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College. The patients were comprised of 95 males and 56 females. The mean age of the patients was (57...
November 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29129665/intravasation-of-sw620-colon-cancer-cell-spheroids-through-the-blood-endothelial-barrier-is-inhibited-by-clinical-drugs-and-flavonoids-in-vitro
#6
Silvio Holzner, Stefan Brenner, Atanas Georgiev Atanasov, Daniel Senfter, Serena Stadler, Chi Huu Nguyen, Adryan Fristiohady, Daniela Milovanovic, Nicole Huttary, Sigurd Krieger, Zsuzsanna Bago-Horvath, Oliver de Wever, Ioannis Tentes, Ali Özmen, Walter Jäger, Helmut Dolznig, Verena Maria Dirsch, Robert Michael Mader, Liselotte Krenn, Georg Krupitza
Mechanisms how colorectal cancer (CRC) cells penetrate blood micro-vessel endothelia and metastasise is poorly understood. To study blood endothelial cell (BEC) barrier breaching by CRC emboli, an in vitro assay measuring BEC-free areas underneath SW620 cell spheroids, so called "circular chemorepellent induced defects" (CCIDs, appearing in consequence of endothelial retraction), was adapted and supported by Western blotting, EIA-, EROD- and luciferase reporter assays. Inhibition of ALOX12 or NF-κB in SW620 cells or BECs, respectively, caused attenuation of CCIDs...
November 10, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29116061/-exosomal-surface-protein-markers-in-diagnosis-of-colorectal-cancer
#7
E N Savvateeva, A A Tikhonov, V I Butvilovskaya, M V Tsybulskaya, A Yu Rubina
Colorectal cancer (CRC) is one of the most common primary malignancies. Early stages of the disease are asymptomatic in the majority of cases, leading to late detection and high mortality. Available noninvasive diagnostic techniques are limited in sensitivity and specificity, and designing new ones is still a pressing problem. Exosomes are membrane-derived microvesicles secreted into human biological fluids and provide a novel way to assess the course of an oncology disease. The review describes the repertoire of exosomal surface biomarkers found in the blood of CRC patients and the prospects of employing multiplexed tests for exosomal markers in early noninvasive diagnosis of cancer...
September 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/29109391/occult-spigelian-hernia-presenting-as-inability-to-complete-colon-cancer-screening-in-a-patient-with-a-history-of-rectal-cancer
#8
Daniel Persinger, Marc D Basson
BACKGROUND While it is well known that abdominal wall hernias can pose obstacles for colonoscopy, these may not be obvious in obese patients, particularly when the hernia is in an unusual place. CASE REPORT A 62-year-old man presented with inability to complete colon cancer screening by means of colonoscopy or barium enema. On exam, he was noted to have a Spigelian hernia present in his left lower quadrant abdominal wall. CT colonography identified incarcerated sigmoid colon within the hernia accounting for his inability to complete colonoscopy or barium enema...
November 7, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29109015/factors-associated-with-participation-in-colorectal-cancer-screening-in-australia-results-from-the-45-and-up-study-cohort
#9
Emily He, Jie-Bin Lew, Sam Egger, Emily Banks, Robyn L Ward, Valerie Beral, Karen Canfell
The Australian Government's National Bowel Cancer Screening Program (NBCSP) was introduced in 2006 to provide free home-based immunochemical faecal occult blood test (iFOBT) to eligible Australians turning 55 and 65years in that year. With the gradual inclusion of additional age cohorts, the rollout of the NBCSP is being implemented in the context of a degree of opportunistic screening being provided through primary care physicians. This study investigated factors associated with ever-uptake of the NBCSP and of any CRC screening using questionnaire data from Australians aged ≥45years enrolled in the 45 and Up Study...
November 3, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29101688/racial-disparities-and-factors-affecting-michigan-colorectal-cancer-screening
#10
Vincent Grzywacz, Nasir Hussain, Neli Ragina
INTRODUCTION: The objective of this study was to investigate the various factors that influence colorectal cancer screening in Michigan using 6091 participants in the Michigan Behavioral Risk Factor Surveillance System representing adults ≥ 50 years old. METHODS: Screening for colorectal cancer was assessed as fecal occult blood testing or colonoscopy/sigmoidoscopy. Full models simultaneously adjusted for alcohol use, angina/coronary heart disease, stroke, heart attack, gender, income, marital status, race, age, diabetes, disability, exercise, health care coverage, health care access, smoking, and mental health...
November 3, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/29096402/risk-adjusted-colorectal-cancer-screening-using-the-fit-and-routine-screening-data-development-of-a-risk-prediction-model
#11
Jennifer Anne Cooper, Nick Parsons, Chris Stinton, Christopher Mathews, Steve Smith, Stephen P Halloran, Sue Moss, Sian Taylor-Phillips
BACKGROUND: The faecal immunochemical test (FIT) is replacing the guaiac faecal occult blood test in colorectal cancer screening. Increased uptake and FIT positivity will challenge colonoscopy services. We developed a risk prediction model combining routine screening data with FIT concentration to improve the accuracy of screening referrals. METHODS: Multivariate analysis used complete cases of those with a positive FIT (⩾20 μg g(-1)) and diagnostic outcome (n=1810; 549 cancers and advanced adenomas)...
November 2, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29079854/identification-of-mst1-as-a-potential-early-detection-biomarker-for-colorectal-cancer-through-a-proteomic-approach
#12
Jiekai Yu, Xiaohui Zhai, Xiaofen Li, Chenhan Zhong, Cheng Guo, Fuquan Yang, Ying Yuan, Shu Zheng
Colorectal cancer (CRC) is a common malignant neoplasm worldwide. It is important to identify new biomarkers for the early detection of CRC. In this study, magnetic beads and the Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) platform were used to analyse CRC and healthy control (HC) serum samples. The CRC diagnosis pattern was established to have a specificity of 94.7% and sensitivity of 92.3% in a blind test. The candidate biomarker serine/threonine kinase 4 (STK4, also known as MST1) was identified by Tandem mass spectrometry (MS/MS) and verified with western blotting and enzyme-linked immunosorbent assay (ELISA)...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29079605/cost-effectiveness-of-the-faecal-immunochemical-test-at-a-range-of-positivity-thresholds-compared-with-the-guaiac-faecal-occult-blood-test-in-the-nhs-bowel-cancer-screening-programme-in-england
#13
Jacqueline Murphy, Stephen Halloran, Alastair Gray
OBJECTIVES: Through the National Health Service (NHS) Bowel Cancer Screening Programme (BCSP), men and women in England aged between 60 and 74 years are invited for colorectal cancer (CRC) screening every 2 years using the guaiac faecal occult blood test (gFOBT). The aim of this analysis was to estimate the cost-utility of the faecal immunochemical test for haemoglobin (FIT) compared with gFOBT for a cohort beginning screening aged 60 years at a range of FIT positivity thresholds. DESIGN: We constructed a cohort-based Markov state transition model of CRC disease progression and screening...
October 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/29074220/development-of-a-multiplexed-tumor-associated-autoantibody-based-blood-test-for-the-detection-of-colorectal-cancer
#14
Chung-Wei Fan, Yung-Bin Kuo, Geng-Pin Lin, Si-Min Chen, Shih-Hsien Chang, Bo-An Li, Err-Cheng Chan
BACKGROUND: Colorectal cancer (CRC) is one of the most common malignancies worldwide, and early diagnosis is vital to improving prognoses. We explored the diagnostic potential of a multiplex autoantibody panel as a biomarker for the detection of CRC by ELISA. METHODS: In total, 192 serum samples (92 CRC and 100 matched controls) were tested against a panel of 12 tumor-associated antigens (TAAs): RPH3AL, RPL36, SLP2, p53, survivin, ANAXA4, SEC61B, CCCAP, NYCO16, NMDAR, PLSCR1, and HDAC5...
October 23, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29071819/is-it-necessary-to-repeat-fecal-occult-blood-tests-with-borderline-results-for-colorectal-cancer-screening
#15
Eunyoung Lee, Yangsoon Lee
The fecal immunochemical test (FIT) is the initial non-invasive investigation of choice for population-based colorectal cancer (CRC) screening. We evaluated the positivity rate in repeated tests using the same fecal specimen that showed borderline results in the FIT. A total of 6,465 patients were tested with the FIT in a tertiary-care hospital from July to December 2016. FIT was done using OC-Sensor PLEDIA (Eiken Chemical Co., Tokyo, Japan). Among 6,465 patients, 364 (5.6%) patients showed a positive FIT result of over 20 μg Hb/g feces...
January 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29061138/the-evidence-base-for-circulating-tumour-dna-blood-based-biomarkers-for-the-early-detection-of-cancer-a-systematic-mapping-review
#16
Ian A Cree, Lesley Uttley, Helen Buckley Woods, Hugh Kikuchi, Anne Reiman, Susan Harnan, Becky L Whiteman, Sian Taylor Philips, Michael Messenger, Angela Cox, Dawn Teare, Orla Sheils, Jacqui Shaw
BACKGROUND: The presence of circulating cell-free DNA from tumours in blood (ctDNA) is of major importance to those interested in early cancer detection, as well as to those wishing to monitor tumour progression or diagnose the presence of activating mutations to guide treatment. In 2014, the UK Early Cancer Detection Consortium undertook a systematic mapping review of the literature to identify blood-based biomarkers with potential for the development of a non-invasive blood test for cancer screening, and which identified this as a major area of interest...
October 23, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29050178/-detection-and-clinical-significance-of-circulating-tumor-cells-in-patients-with-colorectal-carcinoma
#17
D Wang, Y C Yang, H W Yao, L Jin, J Wang, Z G Bai, Z T Zhang
Objective: To detect circulating tumor cells (CTC) in patients with colorectal carcinoma and to evaluate the relationship among CTC, clinic-pathological characteristics and prognosis of colorectal carcinoma. Methods: Peripheral blood samples were obtained from 109 patients with colorectal carcinoma in Department of General Surgery, Beijing Friendship Hospital, Capital Medical University from April 2014 to October 2016. There were 60 male and 49 female patients, aging from 33 to 86 years with a mean age of (65±10) years...
October 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29049756/interventions-to-improve-follow-up-of-positive-results-on-fecal-blood-tests-a-systematic-review
#18
REVIEW
Kevin Selby, Christine Baumgartner, Theodore R Levin, Chyke A Doubeni, Ann G Zauber, Joanne Schottinger, Christopher D Jensen, Jeffrey K Lee, Douglas A Corley
Background: Fecal immunochemical testing is the most commonly used method for colorectal cancer screening worldwide. However, its effectiveness is frequently undermined by failure to obtain follow-up colonoscopy after positive test results. Purpose: To evaluate interventions to improve rates of follow-up colonoscopy for adults after a positive result on a fecal test (guaiac or immunochemical). Data Sources: English-language studies from the Cochrane Central Register of Controlled Trials, PubMed, and Embase from database inception through June 2017...
October 17, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29047146/incidence-and-risk-factors-of-colorectal-cancer-based-on-56-324-health-checkups-7-years-retrospective-cohort-study
#19
Toshiko Fujii, Masayuki Ohisa, Toru Sako, Takayuki Harakawa, Kazuaki Sakanume, Shintaro Nagashima, Aya Sugiyama, Yuuichiro Matsuura, Junko Tanaka
BACKGROUND AND AIM: Although mortality rates of colorectal cancer (CRC) have been increasing in Japan, its screening rates remain stagnant at 19.2% among Japanese population aged >40 years in 2014. To evaluate the importance of CRC screening by fecal occult blood test (FOBT), we estimated the incidence of FOBT-positivity and CRC by sex-age stratification and clarified the risk factors for CRC. METHODS: Between 2007 and 2014, 56,324 residents (21,517 men and 34,807 women) were enrolled in this study...
October 19, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29040021/flexible-sigmoidoscopy-and-ct-colonography-screening-patients-experience-with-and-factors-for-undergoing-screening-insight-from-the-proteus-colon-trial
#20
Carlo Senore, Loredana Correale, Daniele Regge, Cesare Hassan, Gabriella Iussich, Marco Silvani, Arrigo Arrigoni, Lia Morra, Nereo Segnan
Purpose To compare the acceptability of computed tomographic (CT) colonography and flexible sigmoidoscopy (FS) screening and the factors predicting CT colonographic screening participation, targeting participants in a randomized screening trial. Materials and Methods Eligible individuals aged 58 years (n = 1984) living in Turin, Italy, were randomly assigned to be invited to screening for colorectal cancer with FS or CT colonography. After individuals who had died or moved away (n = 28) were excluded, 264 of 976 (27...
October 17, 2017: Radiology
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