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Colorectal cancer blood tests

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https://www.readbyqxmd.com/read/28534334/-impact-of-neutrophil-to-lymphocyte-ratio-on-the-prognosis-of-patients-with-locally-advanced-colorectal-cancer
#1
Huihong Jiang, Hui Wang, Ajian Li, Erjiang Tang, Ying Chen, Aili Wang, Xiaxing Deng, Moubin Lin
OBJECTIVE: To investigate the impact of neutrophil-to-lymphocyte ratio(NLR) on the prognosis of patients with locally advanced colorectal cancer (LACRC). METHODS: Clinicopathological data of 684 patients with stage II(-III( CRC undergoing radical resection at Shanghai Ruijin Hospital from January 2008 to December 2010 were analyzed retrospectively. NLR was calculated from neutrophil and lymphocyte counts on routine blood tests prior to surgery. The optimal cutoff value of NLR for predicting 5-year overall survival (OS) was determined through receiver operating characteristic (ROC) curve analysis...
May 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28530514/public-understanding-of-the-purpose-of-cancer-screening-a-population-based-survey
#2
Amanda J Chorley, Yasemin Hirst, Charlotte Vrinten, Christian von Wagner, Jane Wardle, Jo Waller
Objectives In examining informed choice in cancer screening, we investigated public awareness that some screening programmes aim to prevent cancer, while others seek to detect cancer at an early stage. Methods A population-based survey of adults aged 50-70 in England (n = 1433), including data on demographic characteristics and screening experience. Participants were asked to select the main purpose of cervical, breast, and colorectal cancer screening (both faecal occult blood testing and flexible sigmoidoscopy)...
January 1, 2017: Journal of Medical Screening
https://www.readbyqxmd.com/read/28525616/a-community-laboratory-drop-off-option-for-bowel-screening-test-kits-increases-participation-rates-results-from-an-interrupted-time-series-analysis
#3
P Sandiford, A Buckley, T Robinson, G Tozer, D Holdsworth, J Badkar
Background: Countries with population-based colorectal cancer screening using faecal occult blood test kits performed in the home and posted to the laboratory struggle to achieve higher than 60% uptake. We measured the impact on participation of offering a community laboratory drop-off (CLD) alternative to postal return in New Zealand's Bowel Screening Pilot. Methods: From May to September, 2015, a flyer added to the bowel screening test kit offered CLD as an alternative to returning the kit by post...
May 19, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28521461/kras-and-braf-mutations-in-serum-exosomes-from-patients-with-colorectal-cancer-in-a-chinese-population
#4
Yi-Xin Hao, Yong-Mei Li, Ming Ye, Yan-Yan Guo, Qiu-Wen Li, Xiu-Mei Peng, Qi Wang, Shu-Fang Zhang, Hui-Xia Zhao, He Zhang, Guang-Hui Li, Jian-Hua Zhu, Wen-Hua Xiao
The efficacy of epidermal growth factor receptor- targeted therapy is significantly associated with Kirsten rat sarcoma viral oncogene homolog (KRAS) and B-raf serine/threonine kinase proto-oncogene (BRAF) mutation in patients with colorectal cancer (CRC), for which the standard gene testing is currently performed using tumor tissue DNA. The aim of the present study was to compare the presence of KRAS and BRAF mutations in the serum exosome and primary tumor tissue from patients with CRC. Genomic DNA were extracted from the tumor tissues of 35 patients with histologically-confirmed CRC and exosomal mRNA were obtained from peripheral blood, which were collected from the corresponding patients prior to surgery...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28515797/circulating-nucleosomes-as-new-blood-based-biomarkers-for-detection-of-colorectal-cancer
#5
Jean-François Rahier, Anne Druez, Laurence Faugeras, Jean-Paul Martinet, Myriam Géhénot, Eléonore Josseaux, Marielle Herzog, Jake Micallef, Fabienne George, Monique Delos, Thierry De Ronde, Abdenor Badaoui, Lionel D'Hondt
BACKGROUND: Colonoscopy is currently widely accepted as the gold standard for detection of colorectal cancer (CRC) providing detection of up to 95% of pre-cancerous lesions during the procedure. However, certain limitations exist in most countries including cost and access to the procedure. Moreover, colonoscopy is an invasive technique with risk inherent to the endoscopic procedure. For this reason, alternative screening tests, in particular, fecal occult blood-based tests, have been widely adopted for frontline screening...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28515105/free-circulating-methylated-dna-in-blood-for-diagnosis-staging-prognosis-and-monitoring-of-head-and-neck-squamous-cell-carcinoma-patients-an-observational-prospective-cohort-study
#6
Andreas Schröck, Annette Leisse, Luka de Vos, Heidrun Gevensleben, Freya Dröge, Alina Franzen, Malin Wachendörfer, Friederike Schröck, Joerg Ellinger, Marcus Teschke, Timo Wilhelm-Buchstab, Jennifer Landsberg, Stefan Holdenrieder, Gunther Hartmann, John K Field, Friedrich Bootz, Glen Kristiansen, Dimo Dietrich
BACKGROUND: Circulating cell-free DNA methylation testing in blood has recently received regulatory approval for screening of colorectal cancer. Its application in other clinical settings, including staging, prognosis, prediction, and recurrence monitoring is highly promising, and of particular interest in head and neck squamous cell carcinomas (HNSCC) that represent a heterogeneous group of cancers with unsatisfactory treatment guidelines. METHODS: Short stature homeobox 2 (SHOX2) and septin 9 (SEPT9) DNA methylation in plasma from 649 prospectively enrolled patients (training study: 284 HNSCC/122 control patients; testing study: 141 HNSCC/102 control patients) was quantified before treatment and longitudinally during surveillance...
May 17, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28511430/study-on-the-relation-between-colorectal-cancer-and-gall-bladder-disease
#7
Siddharth Gosavi, R Rama Mishra, Vsm Praveen Kumar
INTRODUCTION: Colorectal cancer is cancer of the large intestine, the lower part of digestive system which includes the sigmoid colon and rectum. AIM: To study the relation of incidence of colorectal cancer with previous gall bladder disease or post-cholecystectomy status, a relation between gall bladder disease and smoking in particular and the most common region of colon involved in colorectal cancer in gall bladder disease and non-gall bladder disease patients...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28509310/circulating-tumor-cells-in-different-stages-of-colorectal-cancer
#8
Petra Eliasova, Michael Pinkas, Katarina Kolostova, Robert Gurlich, Vladimir Bobek
INTRODUCTION: Liquid biopsies are noninvasive tests using blood or body fluids to detect circulating tumor cells (CTCs) or the products of tumor cells, such as fragments of nucleic acids or proteins that are shed into biological fluids from primary tumor or its metastates. The analysis of published clinical studies provides coherent evidence that the presence of CTCs detected in peripheral blood is a strong prognostic factor in patients with colorectal carcinoma (CRC). The aim of the study was to implement size-based separation protocol of CTCs in CRC patients...
2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28507204/detection-of-an-alk-fusion-in-colorectal-carcinoma-by-hybrid-capture-based-assay-of-circulating-tumor-dna
#9
Andrea Z Lai, Alexa B Schrock, Rachel L Erlich, Jeffrey S Ross, Vincent A Miller, Evgeny Yakirevich, Siraj M Ali, Fadi Braiteh
ALK rearrangements have been observed in 0.05%-2.5% of patients with colorectal cancers (CRCs) and are predicted to be oncogenic drivers largely mutually exclusive of KRAS, NRAS, or BRAF alterations. Here we present the case of a patient with metastatic CRC who was treatment naïve at the time of molecular testing. Initial ALK immunohistochemistry (IHC) staining was negative, but parallel genomic profiling of both circulating tumor DNA (ctDNA) and tissue using similar hybrid capture-based assays each identified an identical STRN-ALK fusion...
May 15, 2017: Oncologist
https://www.readbyqxmd.com/read/28505217/effect-of-combined-patient-decision-aid-and-patient-navigation-vs-usual-care-for-colorectal-cancer-screening-in-a-vulnerable-patient-population-a-randomized-clinical-trial
#10
Daniel S Reuland, Alison T Brenner, Richard Hoffman, Andrew McWilliams, Robert L Rhyne, Christina Getrich, Hazel Tapp, Mark A Weaver, Danelle Callan, Laura Cubillos, Brisa Urquieta de Hernandez, Michael P Pignone
Importance: Colorectal cancer (CRC) screening is underused, especially among vulnerable populations. Decision aids and patient navigation are potentially complementary interventions for improving CRC screening rates, but their combined effect on screening completion is unknown. Objective: To determine the combined effect of a CRC screening decision aid and patient navigation compared with usual care on CRC screening completion. Design, Setting, and Participants: In this randomized clinical trial, data were collected from January 2014 to March 2016 at 2 community health center practices, 1 in North Carolina and 1 in New Mexico, serving vulnerable populations...
May 15, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28502729/improving-mutation-screening-in-patients-with-colorectal-cancer-predisposition-using-next-generation-sequencing
#11
Jean-Marc Rey, Vincent Ducros, Pascal Pujol, Qing Wang, Marie-Pierre Buisine, Hanaa Aissaoui, Thierry Maudelonde, Sylviane Olschwang
Identification of genetic alterations is important for family risk assessment in colorectal cancers. Next-generation sequencing (NGS) technologies provide useful tools for single-nucleotide and copy number variation (CNV) identification in many genes and samples simultaneously. Herein, we present the validation of current Multiplicom MASTR designs of mismatch repair combined to familial adenomatous polyposis genes in a single PCR reamplification test for eight DNA samples simultaneously on a MiSeq apparatus...
May 11, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28501944/sociodemographic-predictors-of-participation-in-colorectal-cancer-screening
#12
Ulrik Deding, Anna Sharon Henig, Ann Salling, Christian Torp-Pedersen, Henrik Bøggild
PURPOSE: Colorectal cancer screening by inviting citizens to complete a test for blood in faeces was initiated in Denmark in 2014. We have examined sociodemographic predictors that influence participation to identify factors that could be targeted to increase compliance. METHODS: National registers were used to link data on invitations for colorectal cancer screening in Denmark from 2014 to 2015. Region of residence, age, gender, immigration status, income, educational level and marital status were identified...
May 13, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28494531/stages-of-adoption-for-fobt-and-colonoscopy-tests-for-colorectal-cancer-screening-in-korea
#13
Nhung Bui Cam, Hana Cho, Yoon Young Lee, Mina Suh, Boyoung Park, Jae Kwan Jun, Yeol Kim, Kui Son Choi
Purpose: While colorectal cancer (CRC) is common in Asian countries, screening for CRC is not. Moreover, CRC screening behaviors in Asian populations remain largely unknown. The present study aimed to investigate the stages of adopting CRC screening in Korea according to screening modality. Materials and Methods: Data were obtained from the 2014 Korean National Cancer Screening Survey, a cross-sectional survey that utilized nationally representative random sampling to investigate cancer screening rates...
May 10, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28493543/contribution-of-patient-physician-and-environmental-factors-to-demographic-and-health-variation-in-colonoscopy-follow-up-for-abnormal-colorectal-cancer-screening-test-results
#14
Melissa R Partin, Amy A Gravely, James F Burgess, David A Haggstrom, Sarah E Lillie, David B Nelson, Sean M Nugent, Aasma Shaukat, Shahnaz Sultan, Louise C Walter, Diana J Burgess
BACKGROUND: Patient, physician, and environmental factors were identified, and the authors examined the contribution of these factors to demographic and health variation in colonoscopy follow-up after a positive fecal occult blood test/fecal immunochemical test (FOBT/FIT) screening. METHODS: In total, 76,243 FOBT/FIT-positive patients were identified from 120 Veterans Health Administration (VHA) facilities between August 16, 2009 and March 20, 2011 and were followed for 6 months...
May 11, 2017: Cancer
https://www.readbyqxmd.com/read/28490420/testing-the-effectiveness-of-a-primary-care-intervention-to-improve-uptake-of-colorectal-cancer-screening-a-randomized-controlled-trial-protocol
#15
Natalie Dodd, Mariko Leanne Carey, Elise Mansfield, Christopher Oldmeadow
BACKGROUND: Screening for colorectal cancer (CRC) significantly reduces mortality associated with this disease. In Australia, the National Bowel Cancer Screening Program provides regular fecal occult blood tests (FOBT) for those aged 50 to 74 years, however, participation rates in the program have plateaued at 36%. Given low uptake in the National Bowel Cancer Screening Program, it is necessary to explore alternate methods to increase CRC screening rates. Primary care is a promising adjunct setting to test methods to increase CRC screening participation...
May 10, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28483499/interval-colorectal-cancer-incidence-among-subjects-undergoing-multiple-rounds-of-fecal-immunochemical-testing
#16
Manon van der Vlugt, Esmée J Grobbee, Patrick M M Bossuyt, Amanda Bos, Evelien Bongers, Wolfert Spijker, Ernst J Kuipers, Iris Lansdorp-Vogelaar, Manon C W Spaander, Evelien Dekker
BACKGROUND & AIMS: Among subjects screened for colorectal cancer (CRC) by the guaiac fecal occult blood test, interval cancers develop in 48%-55% of the subjects. Data are limited on how many persons screened by fecal immunochemical tests (FIT), over multiple rounds, develop interval cancers. In the Netherlands, a pilot FIT-based biennial CRC screening program was conducted between 2006 and 2014. We collected and analyzed data from the program on CRCs detected during screening (SD-CRC) and CRCs not detected within the screening program (non-SD-CRC; such as FIT interval cancers, colonoscopy interval cancers and cancer in non-participants)...
May 5, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28480180/streamline-flow-of-the-portal-vein-affects-the-lobar-distribution-of-colorectal-liver-metastases-and-has-a-clinical-impact-on-survival
#17
Jinsoo Rhu, Jin Seok Heo, Seong Ho Choi, Dong Wook Choi, Jong Man Kim, Jae-Won Joh, Choon Hyuck David Kwon
PURPOSE: It is believed that blood from the superior mesenteric vein and splenic vein mixes incompletely in the portal vein and maintains a streamline flow influencing its anatomic distribution. Although several experimental studies have demonstrated the existence of streamlining, clinical studies have shown conflicting results. We investigated whether streamlining of portal vein affects the lobar distribution of colorectal liver metastases and estimated its impact on survival. METHODS: Data of patients who underwent hepatectomy for colorectal liver metastases were retrospectively collected...
May 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28475117/a-label-free-quantitative-fecal-hemoglobin-detection-platform-for-colorectal-cancer-screening
#18
Gita V Soraya, Thanh C Nguyen, Chathurika D Abeyrathne, Duc H Huynh, Jianxiong Chan, Phuong D Nguyen, Babak Nasr, Gursharan Chana, Patrick Kwan, Efstratios Skafidas
The early detection of colorectal cancer is vital for disease management and patient survival. Fecal hemoglobin detection is a widely-adopted method for screening and early diagnosis. Fecal Immunochemical Test (FIT) is favored over the older generation chemical based Fecal Occult Blood Test (FOBT) as it does not require dietary or drug restrictions, and is specific to human blood from the lower digestive tract. To date, no quantitative FIT platforms are available for use in the point-of-care setting. Here, we report proof of principle data of a novel low cost quantitative fecal immunochemical-based biosensor platform that may be further developed into a point-of-care test in low-resource settings...
May 5, 2017: Biosensors
https://www.readbyqxmd.com/read/28469908/measuring-and-improving-cervical-breast-and-colorectal-cancer-screening-rates-in-a-multi-site-urban-practice-in-toronto-canada
#19
Joshua Feldman, Sam Davie, Tara Kiran
Our Family Health Team is located in Toronto, Canada and provides care to over 35 000 patients. Like many practices in Canada, we took an opportunistic approach to cervical, breast, and colorectal cancer screening. We wanted to shift to a proactive, population-based approach but were unable to systematically identify patients overdue for screening or calculate baseline screening rates. Our initiative had two goals: (1) to develop a method for systematically identifying patients eligible for screening and whether they were overdue and (2) to increase screening rates for cervical, breast, and colorectal cancer...
2017: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/28467146/high-test-positivity-and-low-positive-predictive-value-for-colorectal-cancer-of-continued-faecal-occult-blood-test-screening-after-negative-colonoscopy
#20
Jeremy P Brown, Kate Wooldrage, Suzanne Wright, Claire Nickerson, Amanda J Cross, Wendy S Atkin
Objectives The English Bowel Cancer Screening Programme offers biennial guaiac faecal occult blood test (gFOBT) screening to 60-74-year-olds. Participants with positive results are referred for follow-up, but many do not have significant findings. If they remain age eligible, these individuals are reinvited for gFOBT screening. We evaluated the performance of repeat screening in this group. Methods We analysed data on programme participants reinvited to gFOBT screening after either previous negative gFOBT ( n = 327,542), or positive gFOBT followed by a diagnostic investigation negative for colorectal cancer (CRC) or adenomas requiring surveillance ( n = 42,280)...
January 1, 2017: Journal of Medical Screening
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