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Colorectal cancer blood tests

Yangming Gong, Peng Peng, Pingping Bao, Weijian Zhong, Yan Shi, Kai Gu, Ying Zheng, Chunxiao Wu, Sanjun Cai, Ye Xu, Jun Sheng, Fan Wu
BACKGROUND: The incidence and mortality rate of colorectal cancer (CRC) have increased dramatically over the past 3 decades in China due to changes in lifestyle factors. Early detection and treatment guidelines for asymptomatic cases have shown to improve CRC control in developed countries. In response to these challenges, the Shanghai Municipal Government launched a community-based CRC screening program in 2012. MATERIALS AND METHODS: Free initial screening, inclusive of immunochemical fecal occult blood and risk assessment (questionnaire), was provided by community health centers in Shanghai...
March 14, 2018: Oncologist
Roslyn Dillon, Lisa J Croner, John Bucci, Stefanie N Kairs, Jia You, Sharon Beasley, Mark Blimline, Rochele B Carino, Vicky C Chan, Danissa Cuevas, Jeff Diggs, Megan Jennings, Jacob Levy, Ginger Mina, Alvin Yee, Bruce Wilcox
Early detection of colorectal cancer (CRC) is key to reducing associated mortality. Despite the importance of early detection, approximately 40% of individuals in the United States between the ages of 50-75 have never been screened for CRC. The low compliance with colonoscopy and fecal-based screening may be addressed with a non-invasive alternative such as a blood-based test. We describe here the analytical validation of a multiplexed blood-based assay that measures the plasma concentrations of 15 proteins to assess advanced adenoma (AA) and CRC risk in symptomatic patients...
February 23, 2018: Journal of Pharmaceutical and Biomedical Analysis
Janette L Vardy, Haryana Mary Dhillon, Gregory R Pond, Corrinne Renton, Stephen J Clarke, Ian F Tannock
Background: Inflammation promotes the development of malignancy, while a variety of systemic markers of inflammation predict for worse cancer outcomes including recurrence and survival. Here, we evaluate the prognostic impact of cytokine concentrations, full blood count (FBC) differential ratios, cognitive function and fatigue on survival in patients with localised colorectal cancer (CRC). Patients and methods: Data are from a prospective longitudinal study comparing cognitive function and fatigue in patients with CRC who did (n=173) and did not (n=116) receive adjuvant/neoadjuvant chemotherapy...
2018: ESMO Open
Natalie Dodd, Elise Mansfield, Mariko Carey, Christopher Oldmeadow
OBJECTIVE: To examine among people attending outpatient clinics aged 50-74 at average risk of colorectal cancer (CRC): 1) The proportion who report: a) faecal occult blood test (FOBT) within the past two years; and b) colonoscopy within the past five years, including the reasons for undergoing colonoscopy; 2) characteristics associated with under-screening; 3) For those who are under-screened, the proportion who are: a) willing to receive help and the acceptability of different methods of receiving help, and; b) unwilling to receive help and reasons for this...
March 12, 2018: Australian and New Zealand Journal of Public Health
Cynthia M Mojica, Deborah Parra-Medina, Sally Vernon
INTRODUCTION: Colorectal cancer, the second leading cause of cancer death in the United States, is also among the most preventable cancers. However, Latino men are less likely than non-Latino men to engage in preventive screening. Compared with 60% of non-Latino white men and women, only 42% of Latino men are up to date with colorectal cancer screening guidelines, which may result in diagnosis at advanced disease stages and increased deaths. We evaluated the literature on colorectal cancer screening interventions among Latino men to characterize intervention components effective in increasing colorectal cancer screening...
March 8, 2018: Preventing Chronic Disease
Miguel Areia, Manon Cw Spaander, Ernst J Kuipers, Mário Dinis-Ribeiro
Background: Endoscopic screening for gastric cancer is debatable in countries with an intermediate risk. Objective: The objective of this article is to determine the cost-utility of screening strategies for gastric cancer in a European country. Methods: We conducted a cost-utility analysis using a Markov model comparing three screening strategies versus no screening: stand-alone upper endoscopy, endoscopy combined with a colorectal cancer screening colonoscopy after a positive faecal occult blood test or pepsinogens serologic screening...
March 2018: United European Gastroenterology Journal
Jérôme Viguier, Jean-François Morère, Lysel Brignoli-Guibaudet, Christine Lhomel, Sébastien Couraud, François Eisinger
BACKGROUND: The aim of EDIFICE surveys is to improve insight into the behavior of the French population with regard to cancer prevention and participation in screening programs. Via the colorectal cancer screening program, all average-risk individuals in the 50-74-year age group are invited every 2 years to do a guaiac-based or, since April 2015, an immunochemical fecal occult blood test. METHODS: The fifth edition of the nationwide observational survey was conducted by phone interviews using the quota method...
March 5, 2018: Current Oncology Reports
Yoshinori Munemoto, Mitsuro Kanda, Koji Oba, Ho Min Kim, Hiroyoshi Takemoto, Tadamichi Denda, Naoki Nagata, Nao Takano, Mutsumi Fukunaga, Masato Kataoka, Yukihiko Tokunaga, Junichi Sakamoto, Hideyuki Mishima
PURPOSE: Fluorouracil monotherapy, instead of the FOLFOX or FOLFIRI regimen, is administered to patients intolerant to oxaliplatin or irinotecan because of their adverse effects. A prospective clinical trial was designed to evaluate the efficacy and safety of fluorouracil monotherapy combined with panitumumab administered to patients with KRAS wild-type (WT) metastatic colorectal cancer (mCRC) intolerant to oxaliplatin and irinotecan. Screening for potential serum biomarkers to predict early therapeutic responses was conducted...
March 5, 2018: Cancer Chemotherapy and Pharmacology
Amit G Singal, Douglas A Corley, Aruna Kamineni, Michael Garcia, Yingye Zheng, Paul V Doria-Rose, Virginia P Quinn, Christopher D Jensen, Jessica Chubak, Jasmin Tiro, Chyke A Doubeni, Nirupa R Ghai, Celette Sugg Skinner, Karen Wernli, Ethan A Halm
OBJECTIVES: Effectiveness of fecal occult blood test (FOBT) for colorectal cancer (CRC) screening depends on annual testing, but little is known about patterns of repeat stool-based screening within different settings. Our study's objective was to characterize screening patterns and identify factors associated with repeat screening among patients who completed an index guaiac FOBT (gFOBT) or fecal immunochemical test (FIT). METHODS: We performed a multi-center retrospective cohort study among people who completed a FOBT between January 2010 and December 2011 to characterize repeat screening patterns over the subsequent 3 years...
February 27, 2018: American Journal of Gastroenterology
Mathieu Pioche, Christell Ganne, Rodica Gincul, Antoine De Leusse, Julien Marsot, Julien Balique, Alain Fond, Michel Bretagnolle, Luc Henry, Yann Billaud, Romain Malezieux, Marie-Georges Lapalus, Christine Chambon-Augoyard, Emilie Del Tedesco, Olivia Scalone, Jean-Charles Montoy, Benoit Russias, Antoine Detry, Frédéric Veniat, Jin Qiu, Pierre-Jean Valette, Annabel Taillandier, Jean-Christophe Saurin, Josiane Tomczyk-Ferrero, Clémentine Gandilhon, Léa Vecchiato, Patricia Soler-Michel, Thierry Ponchon
OBJECTIVE:  Some patients (10 % - 32 %) with a positive guaiac fecal occult blood test (gFOBT) do not undergo the recommended colonoscopy. The aim of this study was to compare video capsule endoscopy (VCE) and computed tomography colonography (CTC) in terms of participation rate and detection outcomes when offered to patients with a positive gFOBT who did not undergo the recommended colonoscopy. METHODS:  An invitation letter offering CTC or VCE was sent to selected patients after randomization...
February 27, 2018: Endoscopy
Shigeru Fujisaki, Motoi Takashina, Yukari Woo, Ryouichi Tomita, Kenichi Sakurai, Tadatoshi Takayama
We present here a case of transduodenal ampullectomy for an ampullary neoplasm coexisting with gastric and colon cancer. The patient was a 72-year-old man who was referred to our hospital with a positive fecal blood test. Colonoscopy revealed advanced cancer in the descending colon. As part of the preoperative examination, for the colonic cancer, upper gastrointestinal endoscopy was performed. Endoscopy showed a 2 cm elevated lesion(0'-II a type)with subserosalinfil tration on the small curvature side of the upper part of the stomach, and a 2 cm elevated lesion on the papilla of Vater...
February 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
H M C Shantha Kumara, Elli Sutton, Geoffrey A Bellini, Xiaohong Yan, Vesna Cekic Rn, Nipa Dilip Gandhi, Richard L Whelan
Minimally invasive colorectal resection (MICR) for colorectal cancer (CRC) is associated with elevated levels of seven proangiogenic proteins that persist for 2-4 weeks after surgery. The proangiogenic plasma may promote tumor growth postoperatively in patients with residual cancer. To the best of our knowledge, the impact of surgery on interleukin 8 (IL-8) levels is unknown. The aim of the present study was to evaluate plasma IL-8 levels after MICR for CRC. Patients with CRC enrolled in an institutional review board-approved plasma/data bank who underwent MICR were eligible...
March 2018: Molecular and Clinical Oncology
A J Quyn, C G Fraser, J Rodger, A Digan, A S Anderson, R J C Steele
BACKGROUND: Uptake of population-based screening for colorectal cancer in Scotland is around 55 per cent. Abdominal aortic aneurysm (AAA) screening has recently been introduced for men aged 65 years and the reported uptake is 78 per cent. The aim was to determine the impact of a brief intervention on bowel screening in men who attended AAA screening, but previously failed to complete bowel screening. METHODS: Men invited for AAA screening between September 2015 and March 2016 within NHS Tayside were included...
February 21, 2018: British Journal of Surgery
Karen N Barnett, David Weller, Steve Smith, Robert Jc Steele, Peter Vedsted, Sheina Orbell, Sue M Moss, Jane W Melia, Julietta Patnick, Christine Campbell
BACKGROUND: Colorectal cancer (CRC) screening programmes using a guaiac faecal occult blood test (gFOBt) reduce CRC mortality. Interval cancers are diagnosed between screening rounds: reassurance from a negative gFOBt has the potential to influence the pathway to diagnosis of an interval colorectal cancer. METHODS: Twenty-six semi-structured face-to-face interviews were carried out in Scotland and England, with individuals diagnosed with an interval colorectal cancer following a negative gFOBt result...
February 19, 2018: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
Alexandra Leonard, Lezah P McCarthy, Danielle M Pastor
Schwannomas, peripheral nerve sheath tumours arising from Schwann cells, are often associated with inherited disorders such as neurofibromatosis. Gastrointestinal schwannomas, while rare, have been reported in those without personal or family history of neurofibromatosis. Diagnoses of these lesions, however, typically follow evaluations prompted by symptomatic presentations associated with abdominal pain, rectal bleeding, change in bowel habits or positive results on faecal occult blood tests performed for colorectal cancer screening...
February 17, 2018: BMJ Case Reports
Simon J McCluney, Alexandros Giakoustidis, Angela Segler, Juliane Bissel, Roberto Valente, Robert R Hutchins, Ajit T Abraham, Satyajit Bhattacharya, Hemant M Kocher
BACKGROUND AND OBJECTIVES: Approximately 30-50% of patients with colorectal cancer develop liver metastasis for which liver resection is the only hope for potential cure. However, hepatic resection is associated with considerable morbidity. The aim was to detect early complications by utilising the neutrophil: lymphocyte ratio (NLR). METHODS: We performed a retrospective cohort study of patients undergoing hepatic resection at a single institution between 2008 and 2016...
February 15, 2018: Journal of Surgical Oncology
Jie-Bin Lew, D James, B St John, Finlay A Macrae, Jon D Emery, Hooi C Ee, Mark A Jenkins, Emily He, Paul Grogan, Michael Caruana, Diana Sarfati, Marjolein Je Greuter, Veerle Mh Coupé, Karen Canfell
The Australian National Bowel Cancer Screening Program (NBCSP) will fully roll-out 2-yearly screening using immunochemical Faecal Occult Blood Test (iFOBT) in people aged 50-74 years by 2020. In this study, we aimed to estimate the comparative health benefits, harms, and cost-effectiveness of screening with iFOBT, versus other potential alternative or adjunctive technologies. A comprehensive validated microsimulation model, Policy1-Bowel, was used to simulate a total of 13 screening approaches involving use of iFOBT, colonoscopy, sigmoidoscopy, computed tomographic colonography (CTC), faecal DNA (fDNA) and plasma DNA (pDNA), in people aged 50-74 years...
February 14, 2018: International Journal of Cancer. Journal International du Cancer
Ceres Fernandez-Rozadilla, Christiana Kartsonaki, Connor Woolley, Michael McClellan, Deb Whittington, Gareth Horgan, Simon Leedham, Skirmantas Kriaucionis, James East, Ian Tomlinson
BACKGROUND: Colorectal cancer (CRC) screening might be improved by using a measure of prior risk to modulate screening intensity or the faecal immunochemical test threshold. Intermediate molecular biomarkers could aid risk prediction by capturing both known and unknown risk factors. METHODS: We sampled normal bowel mucosa from the proximal colon, distal colon and rectum of 317 individuals undergoing colonoscopy. We defined cases as having a personal history of colorectal polyp(s)/cancer, and controls as having no history of colorectal neoplasia...
February 13, 2018: British Journal of Cancer
Luis Bujanda, Cristina Sarasqueta, Pablo Vega, María Salve, Enrique Quintero, Victoria Alvarez-Sánchez, Fernando Fernández-Bañares, Jaume Boadas, Rafel Campo, Ana Garayoa, Angel Ferrandez, Leyanira Torrealba, Daniel Rodríguez-Alcaide, Mauro D'Amato, Vicent Hernández, Joaquin Cubiella
Background: Aspirin (ASA) is a drug that can cause gastrointestinal lesions and symptoms. Colorectal cancer (CRC) is the most prevalent type of cancer in Western countries. We assessed the effect of aspirin on the diagnostic accuracy of the faecal immunochemical test (FIT) for CRC and/or advanced neoplasia (AN) in patients undergoing colonoscopy for gastrointestinal symptoms. Methods: We conducted a prospective multicentre observational study of diagnostic tests that included patients with gastrointestinal symptoms undergoing colonoscopy between March 2012 and 2014 (the COLONPREDICT study)...
February 2018: United European Gastroenterology Journal
Tobias Niedermaier, Korbinian Weigl, Michael Hoffmeister, Hermann Brenner
Background: Colorectal cancer (CRC) is a common but largely preventable cancer. Although fecal immunochemical tests (FITs) detect the majority of CRCs, they miss some of the cancers and most advanced adenomas (AAs). The potential of blood tests in complementing FITs for the detection of CRC or AA has not yet been systematically investigated. Methods: We conducted a systematic review of performance of FIT combined with an additional blood test for CRC and AA detection versus FIT alone...
February 2018: United European Gastroenterology Journal
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