keyword
MENU ▼
Read by QxMD icon Read
search

Colorectal cancer blood tests

keyword
https://www.readbyqxmd.com/read/29352642/lgals4-ceacam6-tspan8-and-col1a2-blood-markers-for-colorectal-cancer-validation-in-a-cohort-of-subjects-with-positive-fecal-immunochemical-test-result
#1
Maria Teresa Rodia, Rossella Solmi, Francesco Pasini, Elena Nardi, Gabriella Mattei, Giampaolo Ugolini, Luigi Ricciardiello, Pierluigi Strippoli, Rossella Miglio, Mattia Lauriola
BACKGROUND: A noninvasive blood test for the early detection of colorectal cancer (CRC) is highly required. We evaluated a panel of 4 mRNAs as putative markers of CRC. MATERIALS AND METHODS: We tested LGALS4, CEACAM6, TSPAN8, and COL1A2, referred to as the CELTiC panel, using quantitative reverse transcription polymerase chain reaction, on subjects with positive fecal immunochemical test (FIT) results and undergoing colonoscopy. Using a nonparametric test and multinomial logistic model, FIT-positive subjects were compared with CRC patients and healthy individuals...
December 12, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29348907/microsatellite-stability-and-mismatch-repair-proficiency-in-nasopharyngeal-carcinoma-may-not-predict-programmed-death-1-blockade-resistance
#2
Xiyi Liao, Liang Zhao, Sangang Wu, Hua Zheng, Haojun Chen, Huan Zhang, ZiJing Wang, Qin Lin
The US FDA granted accelerated approval to pembrolizumab for microsatellite instability-high and mismatch repair deficient cancers. The response of programmed death-1 blockade in mismatch repair proficiency (pMMR) colorectal cancer is very poor, however, whether such treatment is effective in pMMR nasopharyngeal carcinoma (NPC) remains unknown. We report a case of a 51-year-old man with NPC. PET-CT scan revealed a space-occupying lesion in the left lung, and the pathologic result confirmed the occupying lesion originated from NPC...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29348549/preoperative-anemia-in-colorectal-cancer-relationships-with-tumor-characteristics-systemic-inflammation-and-survival
#3
Juha P Väyrynen, Anne Tuomisto, Sara A Väyrynen, Kai Klintrup, Toni Karhu, Jyrki Mäkelä, Karl-Heinz Herzig, Tuomo J Karttunen, Markus J Mäkinen
Anemia is common in colorectal cancer (CRC) but its relationships with tumor characteristics, systemic inflammation, and survival have not been well characterized. In this study, blood hemoglobin levels and erythrocyte mean corpuscular volume (MCV) levels were measured in two independent cohorts of 148 CRC patients and 208 CRC patients, and their correlation with patient and tumor characteristics, systemic inflammatory markers (modified Glasgow Prognostic Score: mGPS; serum levels of thirteen cytokines, C-reactive protein, albumin), and survival were analyzed...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29324557/factors-influencing-participation-in-fecal-occult-blood-testing-to-screen-for-colorectal-cancer-in-australia-a-scoping-review-protocol
#4
Simone Lee, Andrea Miller
The objective of this scoping review is to examine and map the evidence on the range of factors influencing a person's decision to screen or not screen for colorectal cancer using a fecal occult blood test (FOBT) in Australia, with the view to identifying gaps in the research and informing appropriate questions for future systematic reviews.The question of this review is: what evidence is available around the barriers and facilitators that influence an individual's decision to screen or not screen for colorectal cancer using a fecal occult blood test in Australia?...
January 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29304835/a-systematic-review-of-clinic-and-community-intervention-to-increase-fecal-testing-for-colorectal-cancer-in-rural-and-low-income-populations-in-the-united-states-how-what-and-when
#5
Melinda M Davis, Michele Freeman, Jackilen Shannon, Gloria D Coronado, Kurt C Stange, Jeanne-Marie Guise, Stephanie B Wheeler, David I Buckley
BACKGROUND: Interventions to improve fecal testing for colorectal cancer (CRC) exist, but are not yet routine practice. We conducted this systematic review to determine how implementation strategies and contextual factors influenced the uptake of interventions to increase Fecal Immunochemical Tests (FIT) and Fecal Occult Blood Testing (FOBT) for CRC in rural and low-income populations in the United States. METHODS: We searched Medline and the Cochrane Library from January 1998 through July 2016, and Scopus and clinicaltrials...
January 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29283904/role-of-full-spectrum-endoscopy-in-colorectal-cancer-screening-randomized-trial
#6
Henar Núñez-Rodríguez, Pilar Diez-Redondo, Manuel Pérez-Miranda, Manuel Gonzalez Sagrado, Rosa Conde, Carlos De la Serna
GOALS: The aim of this study was to compare a new, full-spectrum endoscope (Fuse; EndoChoice, Alpharetta, GA) to standard forward-viewing colonoscopy in the detection of colorectal neoplasms. BACKGROUND: Colonoscopy, the gold standard for the detection of colorectal cancer, fails to detect 22% to 28% of polyps, increasing the risk of interval cancer. Endoscopic improvement of the adenoma detection rate decrease interval carcinomas. Full-spectrum endoscopy (FUSE) (330-degree field of view), in a tandem study, has been shown to reduce the adenoma miss rate...
December 27, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29225717/feasibility-of-quantifying-sdc2-methylation-in-stool-dna-for-early-detection-of-colorectal-cancer
#7
Tae Jeong Oh, Hyun Il Oh, Yang Yei Seo, Dongjun Jeong, Changjin Kim, Hyoun Woo Kang, Yoon Dae Han, Hyun Cheol Chung, Nam Kyu Kim, Sungwhan An
Background: Colorectal cancer (CRC) screening is the most efficient strategy to reduce disease-related mortality. Frequent aberrant DNA methylation is known to occur in selected genes and early during CRC development, which has emerged as a new epigenetic biomarker for early detection of CRC. Previously, we reported that we identified that CpG sites of SDC2 were aberrantly methylated in tumor tissues of most CRC patients through comprehensive methylation analysis and demonstrated a high potential of quantification of SDC2 methylation in blood for early detection of colorectal cancer...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/29214818/colorectal-cancer-screening-completion-among-individuals-with-and-without-mental-illnesses-a-comparison-of-2-screening-methods
#8
Bobbi Jo H Yarborough, Ginger C Hanson, Nancy A Perrin, Scott P Stumbo, Carla A Green
PURPOSE: Cancer mortality is worse among people with psychiatric disorders. The purpose of this study was to compare facilitators and rates of colorectal cancer (CRC) screening between people with and without mental illnesses. DESIGN: We conducted a secondary analysis using data from a general population cohort study (N = 92 445) that assessed effects of 2 types of CRC screening test kits-guaiac fecal occult blood testing (gFOBT) and fecal immunochemical testing (FIT)-on CRC screening completion...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29212101/invitation-letters-increase-participation-in-colorectal-cancer-screening-results-from-an-observational-study
#9
Tianzuo Zhan, Thomas Hielscher, Asmé Bilge, Thomas Giese, Christoph Schäfer, Jürgen F Riemann, Matthias P Ebert, Sebastian Belle
Background and Aim Participation rates in the German colorectal cancer screening program are low. Starting in 2013, a large health insurance plan in Bavaria, Germany, is sending an additional invitation letter to insured individuals when they turn 50 or 55 years and become eligible for participation in the program. The letter provides detailed information on colorectal cancer screening. We assessed the impact of the invitation letter on utilization rates. Methods Insurance claims data of a total of 48 343 individuals who had turned 50 or 55 years between 2012 to 2014 were reviewed for utilization rates of screening colonoscopy and fecal blood tests...
December 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29206871/clopidogrel-in-a-combined-therapy-with-anticancer-drugs-effect-on-tumor-growth-metastasis-and-treatment-toxicity-studies-in-animal-models
#10
Agnieszka Denslow, Marta Świtalska, Joanna Jarosz, Diana Papiernik, Kseniia Porshneva, Marcin Nowak, Joanna Wietrzyk
Clopidogrel, a thienopyridine derivative with antiplatelet activity, is widely prescribed for patients with cardiovascular diseases. In addition to antiplatelet activity, antiplatelet agents possess anticancer and antimetastatic properties. Contrary to this, results of some studies have suggested that the use of clopidogrel and other thienopyridines accelerates the progression of breast, colorectal, and prostate cancer. Therefore, in this study, we aimed to evaluate the efficacy of clopidogrel and various anticancer agents as a combined treatment using mouse models of breast, colorectal, and prostate cancer...
2017: PloS One
https://www.readbyqxmd.com/read/29204933/feasibility-and-effectiveness-of-trifluridine-tipiracil-in-metastatic-colorectal-cancer-real-life-data-from-the-netherlands
#11
Johannes J M Kwakman, G Vink, J H Vestjens, L V Beerepoot, J W de Groot, R L Jansen, F L Opdam, H Boot, G J Creemers, J M van Rooijen, M Los, A J E Vulink, H Schut, E van Meerten, A Baars, P Hamberg, E Kapiteijn, D W Sommeijer, C J A Punt, M Koopman
BACKGROUND: The RECOURSE trial showed clinical efficacy for trifluridine/tipiracil for refractory metastatic colorectal cancer patients. We assessed the feasibility and effectiveness of trifluridine/tipiracil in daily clinical practice in The Netherlands. METHODS: Medical records of patients from 17 centers treated in the trifluridine/tipiracil compassionate use program were reviewed and checked for RECOURSE eligibility criteria. Baseline characteristics, safety, and survival times were compared, and prespecified baseline characteristics were tested in multivariate analyses for prognostic significance on overall survival (OS)...
December 4, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29204776/implications-of-hyperthermic-intraperitoneal-chemotherapy-perfusion-related-hyperglycemia
#12
Camille L Stewart, Ana Gleisner, Alison Halpern, Irada Ibrahim-Zada, Rodrigo Asturias Luna, Nathan Pearlman, Csaba Gajdos, Barish Edil, Martin McCarter
BACKGROUND: Hyperthermic intraperitoneal chemotherapy (HIPEC) administration can be associated with hyperglycemia during perfusion. Little is known about this effect, and no previous studies have examined patient characteristics associated with perfusion-related hyperglycemia. METHODS: We retrospectively identified consecutive patients at a single institution treated with HIPEC from 8/2003 to 10/2016 who had intraoperative blood glucose measured. Hypertonic 1.5% dextrose-containing peritoneal dialysate was used as carrier solution in all patients...
December 4, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29197686/the-impact-of-screening-on-cancer-incidence-and-mortality-in-missouri-usa-2004-2013
#13
Y Yoshida, C L Schmaltz, J Jackson-Thompson, E J Simoes
OBJECTIVES: Population-based evidence regarding impact of cancer screenings and cancer rates in Missouri is lacking. This study examined whether screenings of breast cancer, cervical cancer, and colorectal cancer impact early-stage cancer incidence and mortality in Missouri. STUDY DESIGN: This is an ecological study based on county-specific estimates of selected cancer screening prevalence and early-stage cancer incidence and cancer mortality. METHODS: County-specific prevalence of clinical breast examination, mammography, Pap test, sigmoidoscopy or colonoscopy, and fecal occult blood test (FOBT) were generated from Missouri County-Level Study (2003, 2007, and 2011)...
November 30, 2017: Public Health
https://www.readbyqxmd.com/read/29189767/blood-based-protein-signatures-for-early-detection-of-colorectal-cancer-a-systematic-review
#14
Megha Bhardwaj, Anton Gies, Simone Werner, Petra Schrotz-King, Hermann Brenner
OBJECTIVES: Blood-based proteins might be an attractive option for early detection of colorectal cancer (CRC), but individually they are unlikely to achieve the diagnostic performance required for population based screening. We aimed at summarizing current evidence of diagnostic performance of signatures based on multiple proteins for early detection of CRC. METHODS: A systematic literature review adhering to the PRISMA (preferred reporting items for systematic reviews and meta-analysis) guidelines was performed...
November 30, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29184444/development-and-validation-of-a-panel-of-five-proteins-as-blood-biomarkers-for-early-detection-of-colorectal-cancer
#15
Hongda Chen, Jing Qian, Simone Werner, Katarina Cuk, Phillip Knebel, Hermann Brenner
Objective: Reliable noninvasive biomarkers for early detection of colorectal cancer (CRC) are highly desirable for efficient population-based screening with high adherence rates. We aimed to discover and validate blood-based protein markers for the early detection of CRC. Patients and methods: A two-stage design with a discovery and a validation set was used. In the discovery phase, plasma levels of 92 protein markers and serum levels of TP53 autoantibody were measured in 226 clinically recruited CRC patients and 118 controls who were free of colorectal neoplasms at screening colonoscopy...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/29183246/uptake-trends-in-the-scottish-bowel-screening-programme-and-the-influences-of-age-sex-and-deprivation
#16
Aaron J Quyn, Callum G Fraser, Greig Stanners, Francis A Carey, Claire Carden, Aasma Shaukat, Robert Jc Steele
Objective Age, sex, and deprivation are known factors influencing colorectal (bowel) cancer screening uptake. We investigated the influence of these factors on uptake over time. Methods Data from the Scottish Bowel Screening Programme (SBoSP) were collected between 2007 and 2014. End-points for analysis were uptake, faecal occult blood test positivity, and disease detection, adjusted for age, sex, deprivation, and year of screening. Results From 5,308,336 individual screening episodes documented, uptake gradually increased with increasing age up to 65-69 and was lower in men than women (52...
January 1, 2017: Journal of Medical Screening
https://www.readbyqxmd.com/read/29181829/long-term-endurance-training-increases-serum-cathepsin-s-levels-in-healthy-female-subjects
#17
M Sponder, C Minichsdorfer, I-A Campean, M Emich, M Fritzer-Szekeres, B Litschauer, J Strametz-Juranek
BACKGROUND: Circulating cathepsin S (CS) has been associated with a lower risk for breast cancer in a large Swedish cohort. Long-term physical activity has been shown to have beneficial effects on the development of various cancer subtypes, in particular breast and colorectal cancers. The aim of this study was to investigate the effect of long-term endurance sport on CS levels in females. MATERIAL AND METHODS: Thirty-six of 40 subjects completed the study. Subjects were told to increase their activity pensum for 8 months reaching 150 min/week moderate or 75 min/week intense exercise...
November 27, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29178362/the-relationship-between-18f-fdg-petct-derived-markers-of-tumour-metabolism-and-systemic-inflammation-in-patients-with-recurrent-disease-following-surgery-for-colorectal-cancer
#18
Stephen T McSorley, Bo Y Khor, Kwong Tsang, David Colville, Sai Han, Paul G Horgan, Donald C McMillan
AIM: 18 F FDG-PETCT derived markers of tumour metabolism have been reported to have prognostic significance in a variety of tumours. Host inflammation is also recognised to have prognostic significance. The aim of the present study was to investigate the relationship between these markers and host systemic inflammation in patients undergoing elective surgery for colorectal cancer. METHODS: Patients with histologically confirmed colorectal cancer, who underwent elective surgery between 2008 and 2015, who also underwent 18 F FDG-PETCT, at a single centre were included (n =103)...
November 25, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29178095/-efficacy-analysis-of-proximally-extended-resection-for-locally-advanced-rectal-cancer-after-neoadjuvant-chemoradiotherapy
#19
Qiyuan Qin, Yingyi Kuang, Tenghui Ma, Yali Wu, Huaiming Wang, Yanna Pi, Hui Wang, Lei Wang
OBJECTIVE: To evaluate the short-term outcomes and perioperative safety of proximally extended resection for locally advanced rectal cancer after neoadjuvant chemoradiotherapy. METHODS: From colorectal cancer database in The Sixth Affiliated Hospital of Sun Yat-sen University, a cohort of patients who underwent neoadjuvant chemoradiotherapy(1.8-2.0 Gy per day, 25-28 fractions, concurrent fluorouracil-based chemotherapy) followed by curative sphincter-preserving surgery for locally advanced rectal cancer between May 2016 and June 2017 were retrospectively identified...
November 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29178094/-status-quo-of-colorectal-cancer-screening-in-guangzhou-community
#20
Yujie Zhao, Zhizhong Pan
The incidence of colorectal cancer (CRC) in China is gradually increasing as a result of the economic development and dietary change. Since it usually takes a long time for precancerous lesions (e.g. adenoma) to develop into cancer, proper cancer screening is useful to discover and to remove these early lesions, while the patients can achieve long-term survival. Hence, developing a well-organized cancer screening system is necessary for the early detection and intervention of potential CRC. Sun Yat-sen University Cancer Center (SYSUCC) has been developing a community-based cancer screening program, using questionnaires and fecal occult blood test to identify the residents with high risks of CRC...
November 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
keyword
keyword
24481
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"