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https://www.readbyqxmd.com/read/28346301/psychological-outcomes-following-burn-injuries
#1
Shelley Wiechman, Glenn Saxe, James A Fauerbach
No abstract text is available yet for this article.
March 24, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28341260/the-effect-of-preexisting-respiratory-co-morbidities-on-burn-outcomes
#2
Laquanda T Knowlin, Lindsay B Stanford, Bruce A Cairns, Anthony G Charles
INTRODUCTION: Burns cause physiologic changes in multiple organ systems in the body. Burn mortality is usually attributable to pulmonary complications, which can occur in up to 41% of patients admitted to the hospital after burn. Patients with preexisting comorbidities such as chronic lung diseases may be more susceptible. We therefore sought to examine the impact of preexisting respiratory disease on burn outcomes. METHODS: A retrospective analysis of patients admitted to a regional burn center from 2002-2012...
March 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28341255/damage-associated-molecular-patterns-damps-released-after-burn-are-associated-with-inflammation-and-monocyte-activation
#3
Meenakshi Rani, Susannah E Nicholson, Qiong Zhang, Martin G Schwacha
Burns are associated with activation of the innate immunity that can contribute to complications. Damage-associated molecular patterns (DAMPs) released after tissue injury play a critical role in the activation of the innate immunity, which appears to be mediated via toll-like receptors (TLRs). Previous findings have shown that TLRs and TLR-mediated responses are up-regulated after burn. Nonetheless, it is unclear what impact burn has on circulating levels of DAMPs. To study this, male C57BL/6 mice were subjected to a major burn or sham procedure...
March 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28341091/predictors-of-moderate-to-severe-fatigue-12-months-following-admission-to-hospital-for-burn-results-from-the-burns-registry-of-australia-and-new-zealand-branz-long-term-outcomes-project
#4
Belinda J Gabbe, Heather Cleland, Dina Watterson, Rebecca Schrale, Sally McRae, Susan Taggart, Anne Darton, Fiona Wood, Dale W Edgar
INTRODUCTION: Fatigue has been identified as an outcome of concern following burn but is rarely captured in outcomes studies. We aimed to: (i) describe the prevalence, and predictors, of moderate to severe fatigue in the first 12 months following burn, and (ii) establish the association between fatigue and health-related quality of life and work outcomes. METHODS: Adult burns patients, admitted >24h, were recruited from five BRANZ sites. Participants were followed-up at 1-, 6-, and 12-months after injury using the Brief Fatigue Inventory (BFI), 36-item Short Form Health Survey (SF-36) and the Sickness Impact Profile (SIP)-work scale...
December 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28340575/nox2-deficiency-alters-macrophage-phenotype-through-an-il-10-stat3-dependent-mechanism-implications-for-traumatic-brain-injury
#5
James P Barrett, Rebecca J Henry, Sonia Villapol, Bogdan A Stoica, Alok Kumar, Mark P Burns, Alan I Faden, David J Loane
BACKGROUND: NADPH oxidase (NOX2) is an enzyme system that generates reactive oxygen species (ROS) in microglia and macrophages. Excessive ROS production is linked with neuroinflammation and chronic neurodegeneration following traumatic brain injury (TBI). Redox signaling regulates macrophage/microglial phenotypic responses (pro-inflammatory versus anti-inflammatory), and NOX2 inhibition following moderate-to-severe TBI markedly reduces pro-inflammatory activation of macrophages/microglia resulting in concomitant increases in anti-inflammatory responses...
March 24, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28340258/hydrocodone-is-more-effective-than-morphine-or-oxycodone-in-suppressing-the-development-of-burn-induced-mechanical-allodynia
#6
Michael A Emery, M L Shawn Bates, Paul J Wellman, Shoshana Eitan
Background. : Pain is the most frequent complaint of burn-injured patients. Opioids are commonly used in the course of treatment. However, there is a lack of rodent studies that examine the differential effects of various opioids on burn pain. Objective. : This study compared the ability of morphine, oxycodone, and hydrocodone to suppress the development of burn-induced mechanical allodynia and reduce pain sensitivity. Methods. : Mice were examined for their baseline pain sensitivity thresholds using the von Frey Filaments test...
March 18, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28340168/young-children-s-acute-stress-after-a-burn-injury-disentangling-the-role-of-injury-severity-and-parental-acute-stress
#7
Ann-Christin Haag, Markus A Landolt
 Although injury severity and parental stress are strong predictors of posttraumatic adjustment in young children after burns, little is known about the interplay of these variables. This study aimed at clarifying mediation processes between injury severity and mother's, father's, and young child's acute stress.   Structural equation modeling was used to examine the relationships between injury severity and parental and child acute stress. Parents of 138 burn-injured children (ages 1-4 years) completed standardized questionnaires on average 19 days postinjury...
March 18, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/28340085/prevalence-of-neuropathic-pain-in-patients-with-traumatic-brachial-plexus-injury-a-multicenter-prospective-hospital-based-study
#8
Palma Ciaramitaro, Luca Padua, Grazia Devigili, Eugenia Rota, Stefano Tamburin, Roberto Eleopra, Giorgio Cruccu, Andrea Truini
Objective. : Prevalence and clinical characteristics of neuropathic pain due to traumatic brachial plexus injury. Design. : Observational epidemiological study. Setting. : Hospital-based multicenter study. Subjects. : One hundred seven prospectively enrolled patients with brachial plexus injury. Methods. : All the patients underwent clinical examination and neurophysiological testing for a definitive diagnosis of the brachial plexus lesion...
March 3, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28338594/the-association-of-non-accidental-trauma-with-historical-factors-exam-findings-and-diagnostic-testing-during-the-initial-trauma-evaluation
#9
Mauricio A Escobar, Marc Auerbach, Katherine Flynn-O'Brien, Gunjan Tiyyagura, Matthew A Borgman, Susan J Duffy, Kelly Falcone, Rita Burke, John M Cox, Sabine Maguire
Early identification of non-accidental trauma (NAT) is a critical component of pediatric trauma care. Literature searches were conducted related to the association of NAT with seven key areas: history, exam findings (burns, oral trauma, bruising) and imaging (fractures, abdominal and brain injuries). When available, odds ratios (OR) with 95% confidence intervals (CI) for associations with NAT are presented. Systematic reviews have been published in six of the seven key areas and are described. The operational definition of NAT was widely variable across studies, prohibiting meta-analysis...
March 23, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28338519/incidence-of-sinusitis-in-burn-victims-and-association-with-inhalational-injury
#10
Nicole M Melchior, Eric M Melchior, Linwood R Haith
The purpose of this study is to determine the incidence of sinusitis in mechanically ventilated burn victims and to examine if the presence of inhalational injury increases the likelihood of developing sinusitis. The authors hypothesize that the incidence of sinusitis will be increased in burn victims who have concomitant inhalational injury. A retrospective chart analysis was performed on all patients who were admitted to the Nathan Speare Regional Burn Treatment Center over a 24-month time frame. Patients who were mechanically ventilated for greater than 24 hours were then selected, resulting in a total of 137 patients for analysis...
March 22, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28338518/scar-management-following-burn-injury
#11
Edward E Tredget, Jeffrey W Shupp, Jeffrey C Schneider
No abstract text is available yet for this article.
March 21, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28338404/effect-of-histone-deacetylase-inhibitor-butyroyloxymethyl-diethyl-phosphate-an-7-on-corneal-neovascularization-in-a-mouse-model
#12
Michal Schaap-Fogler, Irit Bahar, Ada Rephaeli, Mor Dahbash, Abraham Nudelman, Eitan Livny, Tilda Barliya, Yael Nisgav, Tami Livnat
PURPOSE: To examine whether butyroyloxymethyl-diethyl phosphate (AN-7), a histone deacetylase inhibitor, inhibits chemically induced corneal neovascularization (NV) in mice. METHODS: Corneal NV was induced in the right eye of male C57BL mice by application of a mixture of 75% silver nitrate and 25% potassium nitrate to the corneal center. Immediately thereafter, the mice were randomized into 2 groups, receiving an intraperitoneal injection of AN-7 or saline, which served as control...
March 24, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28337463/skin-tissue-engineering-application-of-adipose-derived-stem-cells
#13
REVIEW
Agnes S Klar, Jakub Zimoch, Thomas Biedermann
Perception of the adipose tissue has changed dramatically over the last few decades. Identification of adipose-derived stem cells (ASCs) ultimately transformed paradigm of this tissue from a passive energy depot into a promising stem cell source with properties of self-renewal and multipotential differentiation. As compared to bone marrow-derived stem cells (BMSCs), ASCs are more easily accessible and their isolation yields higher amount of stem cells. Therefore, the ASCs are of high interest for stem cell-based therapies and skin tissue engineering...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28333758/cutaneous-burn-injury-modulates-urinary-antimicrobial-peptide-responses-and-the-urinary-microbiome
#14
Jennifer K Plichta, Casey J Holmes, Vanessa Nienhouse, Michelle Puszynski, Xiang Gao, Qunfeng Dong, Huaiying Lin, James Sinacore, Michael Zilliox, Evelyn Toh, David E Nelson, Richard L Gamelli, Katherine A Radek
OBJECTIVES: Characterization of urinary bacterial microbiome and antimicrobial peptides after burn injury to identify potential mechanisms leading to urinary tract infections and associated morbidities in burn patients. DESIGN: Retrospective cohort study using human urine from control and burn subjects. SETTING: University research laboratory. PATIENTS: Burn patients. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Urine samples from catheterized burn patients were collected hourly for up to 40 hours...
March 22, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28330646/is-it-time-for-a-change-in-the-approach-to-chemical-burns-the-role-of-diphoterine-%C3%A2-in-the-management-of-cutaneous-and-ocular-chemical-injuries
#15
REVIEW
C J Lewis, A Al-Mousawi, A Jha, K P Allison
A multitude of household and occupational compounds have the potential to induce chemical burns to the eye and skin. Without prompt intervention, irreversible visual loss and disfigurement may prevail. Diphoterine(®) and Hexafluorine(®) are amphoteric and hypertonic chelating solutions used in the management of general chemical and hydrofluoric acid burns, respectively. They rapidly neutralise both acid and alkali agents without heat release and limit diffusion, making them superior to water irrigation alone...
February 27, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28330489/profiling-intraoral-neuropathic-disturbances-following-lingual-nerve-injury-and-in-burning-mouth-syndrome
#16
Amely Hartmann, Robin Seeberger, Malte Bittner, Roman Rolke, Claudia Welte-Jzyk, Monika Daubländer
BACKGROUND: The aim of the study was to analyse intraoral neurophysiological changes in patients with unilateral lingual nerve lesions as well as patients with Burning Mouth Syndrome (BMS) by applying a standardized Quantitative Sensory Testing (QST) protocol. METHODS: The study included patients suffering from a peripheral lesion of the lingual nerve (n = 4), from BMS (n = 5) and healthy controls (n = 8). Neurophysiological tests were performed in the innervation areas of the tongue bilaterally...
March 23, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28329734/elevated-mif-2-levels-predict-mortality-in-critically-ill-patients
#17
Julia Pohl, Ulrike B Hendgen-Cotta, Pia Stock, Peter Luedike, Tienush Rassaf
PURPOSE: D-dopachrome tautomerase (MIF-2 or DDT) is a member of the macrophage migration inhibitory factor (MIF) superfamily and a close structural homolog to MIF. Circulating MIF-2 has been described to be elevated in patients suffering from sepsis, severe burn injury and after surgery. We sought to evaluate the prognostic value of MIF-2 in critically ill patients. METHODS: A total of 72 patients were studied upon admission to the medical intensive care unit (ICU)...
March 16, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28328660/addressing-the-barriers-to-bioimpedance-spectroscopy-use-in-major-burns-alternate-electrode-placement
#18
Pippa Kenworthy, Tiffany L Grisbrook, Michael Phillips, William Gibson, Fiona M Wood, Dale W Edgar
Bioimpedance spectroscopy (BIS) is a method used to assess body composition and fluid distribution. As a technology for measurement of fluid shifts during acute burn resuscitation, there are potential barriers to its use due to the location of wounds. This study aimed to determine whether alternate electrode positions were a suitable alternative compared to standardized (manufacturer) positions in moderate to large size burns for the measurement of BIS resistance and fluid changes. BIS measurements were collected in standard and alternate electrode placements and in an open wound and Acticoat™ dressing condition...
March 15, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28328658/a-systematic-review-on-the-epidemiology-of-pediatric-burn-in-iran
#19
Sayed Saeed Hashemi, Asaad Sharhani, Bahare Lotfi, Toraj Ahmadi-Juibari, Zahra Shaahmadi, Abbas Aghaei
Burn is the most common pediatric injuries all over the world. The aim of this study was to study the epidemiology of burn in under 15-year-old Iranian children by applying a systematic review. The related articles published before 2016 have been gathered from international databases by using the keywords in term of pediatric burns such as ScienceDirect, PubMed, Iranmedex, Google Scholar, Embase, Magiran, and SID. The checklists of STROBE have been applied to evaluate the quality of the reviewed data. A total of 35 relevant studies were extracted and evaluated...
March 15, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28326683/restoring-full-thickness-defects-with-spray-skin-in-conjunction-with-dermal-regenerate-template-and-split-thickness-skin-grafting-a-pilot-study
#20
Daniel Hammer, Juan L Rendon, Jennifer Sabino, Kerry Latham, Mark E Fleming, Ian L Valerio
Complex, full-thickness soft tissue defects secondary to large burns, trauma and war-related injuries continue to challenge reconstructive surgeons. To achieve positive surgical outcomes in these patient populations, novel approaches are needed to restore the functional, protective and aesthetic properties of skin. Herein, we provide the first report describing the staged use of a dermal regenerate template (DRT) with a spray-on epidermal regenerative modality (spray skin) in addition to autologous split-thickness skin grafting (STSG) in non-burn trauma and compare these results with those of patients treated with DRT and STSG alone...
March 22, 2017: Journal of Tissue Engineering and Regenerative Medicine
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