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Burn Injury

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https://www.readbyqxmd.com/read/29655989/in-vivo-migration-of-mesenchymal-stem-cells-to-burn-injury-sites-and-their-therapeutic-effects-in-a-living-mouse-model
#1
Eun Jung Oh, Ho Won Lee, Senthilkumar Kalimuthu, Tae Jung Kim, Hyun Mi Kim, Se Hwan Baek, Liya Zhu, Ji Min Oh, Seung Hyun Son, Ho Yun Chung, Byeong-Cheol Ahn
Mesenchymal stem cell (MSC)-based therapy has emerged as a promising therapeutic strategy for tissue regeneration and repair. In this study, we non-invasively monitored the tracking of MSCs toward burn injury sites using MSCs expressing firefly luciferase (Fluc) gene in living mice, and evaluated the effects of the MSCs at the injury site. Murine MSCs co-expressing Fluc and green fluorescent protein (GFP) were established using a retroviral system (referred to as MSC/Fluc). To evaluate the ability of MSC migration toward burn injury sites, cutaneous burn injury was induced in the dorsal skin of mice...
April 12, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29651952/special-traumatized-populations-burns-and-hypothermia
#2
Shruti Mehrotra, Amita Misir
It is important for physicians treating children to be aware of unique presentation that require expertise and knowledge. Two areas of importance when caring for traumatized children are Thermal Burn Injuries, and Hypothermia. Burns commonly result in morbidity in children; as such, the appropriate identification of the severity of the burn and appropriate management are integral to minimize the complications of burns during the acute phase. Attention to proper fluid management is paramount. Knowledge of types of solutions to use during Burn treatment is important...
April 11, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/29651394/the-healing-effect-of-sesame-oil-camphor-and-honey-on-second-degree-burn-wounds-in-rat
#3
Reza Vaghardoost, Seyed GholamReza Mousavi Majd, Hamid Tebyanian, Hamid Babavalian, Leila Malaei, Mitra Niazi, Ali Javdani
BACKGROUND: Many studies were carried out to improve sophisticated dressings to accelerate healing processes and reduce the microbial burden in burn wounds. This study evaluated the healing effect of herbal ointment containing extract of sesame oil, camphor and honey on second degree burn wounds in rats in comparison with daily dressing oil vaseline. METHODS: Forty rats were randomly assigned to two equal groups. A deep second degree burn was formed on the back of each rat with using a standard burning technique...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29651392/the-effect-of-rhythmic-breathing-on-pain-of-dressing-change-in-patients-with-burns-referred-to-ayatollah-mousavi-hospital
#4
Mehri Bozorg-Nejad, Hammed Azizkhani, Fatimah Mohaddes Ardebili, Sayed Kazem Mousavi, Farzad Manafi, Agha Fatemeh Hosseini
BACKGROUND: Burn is the worst tragedy among modern societies that individuals may experience. One of the most important problems of burns is pain; particularly at the time of treatment including burn dressings, debridement, surgical incisions and physiotherapy. The aim of this study was to determine the effect of rhythmic breathing on pain of dressing change in patients with burns. METHODS: This semi-experimental clinical trial study with a control group was conducted on 60 eligible burn patients who were selected using convenient sampling method and allocated randomly in two groups of test and control (each n=30)...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29651390/comparison-of-albizia-julibressin-and-silver-sulfadiazine-in-healing-of-second-and-third-degree-burns
#5
Hossein Asgarirad, Aroona Chabra, Mahnaz Rahimnejad, Ahmad Zaghi Hosseinzadeh, Ali Davoodi, Mohammad Azadbakht
BACKGROUND: Large numbers of population suffer from burn annually. The promising treatment of burn has not been identified yet. Albizia julibressin ( A. julibressin ) in Fabaceae family is popular for its antiseptic activity. This prospective study was designed to compare the wound healing effects of A. julibressin gel (AG) with silver sulfadiazine (SSD). METHODS: This single blind clinical trial was performed on 40 patients with second and third degree burns. 20 patients treated with SSD and 20 other patients received A...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29651389/the-healing-effect-of-n-hexan-dichloromethane-extract-root-onosma-bulbotrichum-in-second-degree-burns
#6
Aliasghar Hemmati, Forough Namjuyan, Sadegh Yousefi, Gholamreza Housmand, Hossein Khadem Haghighian, Anahita Rezaei
BACKGROUND: Wound healing is the process of repair following an injury to the skin and other soft tissues. In this study, the effect of n-hexane d-chloromethane extract (1: 1) of root Onosma bulbotrichum DC on the second degree burn in rabbit model was investigated. METHODS: Thirty-six adult rabbits of both sexes were randomly divided into six groups, control (without treatment), negative control (treatment with cold cream), positive control (treatment with silver sulfadiazine), and treatment groups with 5%, 1% and 2% O...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29643795/ocular-injury-due-to-potassium-permanganate-granules
#7
Chareenun Chirapapaisan, Pinnita Prabhasawat, Sabong Srivannaboon, Vatookarn Roongpoovapatr, Piyada Chitsuthipakorn
Purpose: We report a rare case of ocular injury due to potassium permanganate (KMnO4 ) granules in a child. Methods: This is a retrospective case report. Results: A 2-year-old boy was transferred to our emergency room with severe pain in his right eye, inflamed eyelids, and brownish stains on his fingers. Chemical injury was suspected. Copious eye irrigation was immediately performed. Diffuse brownish splotches were then observed at the inferior bulbar conjunctiva...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29626545/hypoxia-selective-allosteric-destabilization-of-activin-receptor-like-kinases-a-potential-therapeutic-avenue-for-prophylaxis-of-heterotopic-ossification
#8
Guorong Lu, Mary R Tandang-Silvas, Alyssa C Dawson, Trenton J Dawson, Jay C Groppe
Heterotopic ossification (HO), the pathological extraskeletal formation of bone, can arise from blast injuries, severe burns, orthopedic procedures and gain-of-function mutations in a component of the bone morphogenetic protein (BMP) signaling pathway, the ACVR1/ALK2 receptor serine-threonine (protein) kinase, causative of Fibrodysplasia Ossificans Progressiva (FOP). All three ALKs (-2, -3, -6) that play roles in bone morphogenesis contribute to trauma-induced HO, hence are well-validated pharmacological targets...
April 4, 2018: Bone
https://www.readbyqxmd.com/read/29624027/percussive-ventilation-rescue-after-hfov-failure-in-severe-ards-due-to-burn-injury
#9
Marco Piastra, Tony C Morena, Flavia Toni, Andrea DE Bellis, Giorgio Conti
No abstract text is available yet for this article.
April 5, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29622333/emergency-care-of-pediatric-burns
#10
REVIEW
Ashley M Strobel, Ryan Fey
Although the overall incidence of and mortality rate associated with burn injury have decreased in recent decades, burns remain a significant source of morbidity and mortality in children. Children with major burns require emergent resuscitation. Resuscitation is similar to that for adults, including pain control, airway management, and administration of intravenous fluid. However, in pediatrics, fluid resuscitation is needed for burns greater than or equal to 15% of total body surface area (TBSA) compared with burns greater than or equal to 20% TBSA for adults...
May 2018: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/29621119/clinical-importance-of-a-cytokine-network-in-major-burns
#11
Hiroshi Matsuura, Hisatake Matsumoto, Akinori Osuka, Hiroshi Ogura, Kentaro Shimizu, Sujin Kang, Toshio Tanaka, Masashi Ueyama, Takeshi Shimazu
Major burns elicit an acute inflammatory response including various inflammatory cytokines. Cytokines play mutual interacting roles in inflammatory diseases. There is little evidence of the clinical significance of the cytokine network in patients with major burns. This study aimed to investigate the clinical significance of the cytokine network in patients with major burn. This prospective observational study comprising 38 patients with major burns (total body surface area (%TBSA) ≥ 20%) and 12 healthy controls was conducted from April 2014 to December 2016...
April 4, 2018: Shock
https://www.readbyqxmd.com/read/29619789/inadvertent-thermal-injury-following-knee-arthroscopic-surgery-in-a-pediatric-patient
#12
Daegyu Kwon, Byung-Gun Kim, Chunwoo Yang, Jonghun Won, Yoonjung Kim
Inadvertent thermal injury can occur in pediatric patients under general anesthesia during knee arthroscopic surgery. Here, we report the case of a 10-year-old boy who underwent knee arthroscopic surgery under general anesthesia. After the surgery, he complained of pain in the left lower part of his chin and was diagnosed as having a thermal burn. At three-month follow-up, he recovered without any abnormalities except mild hypertrophy of the wound area. Although rare, arthroscopic surgery has the potential to cause thermal injury from the light source...
April 2018: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29618839/metformin-adapts-its-cellular-effects-to-bioenergetic-status-in-a-model-of-metabolic-dysfunction
#13
Christopher Auger, Thibacg Sivayoganathan, Abdikarim Abdullahi, Alexandra Parousis, Bo Wen Pang, Marc G Jeschke
Thermal injury induces a complex immunometabolic response, characterized by hyperglycemia, extensive inflammation and persistent hypermetabolism. It has been suggested that attenuation of the hypermetabolic response is beneficial for patient wellbeing. To that effect, metformin represents an attractive therapeutic agent, as its effects on glycemia, inflammation and bioenergetics can improve outcomes in burn patients. Therefore, we studied metformin and its effects on mitochondrial bioenergetics in a murine model of thermal injury...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29618709/-factors-related-to-frequent-emergency-hospital-refusal-of-ambulance-transport-calls
#14
Mika Kumagai, Naomi Kitano, Erika Komatsu, Hiroyuki Doba, Masami Ueno
Purpose Among the factors that adversely affect the time needed for ambulance transport, one factor for which intervention is possible is the time it takes to choose a medical receiving facility. This research clarified the characteristics of the time, location, and severity of medical emergencies in which the choice of hospital was difficult.Methods The research covered a 1-year period from January 1 through December 31, 2014, investigating all incidents of ambulance transport for patients in Wakayama Prefecture, except for those involving pediatric patients, amounting to a total of 41,574 incidents...
2018: [Nihon Kōshū Eisei Zasshi] Japanese Journal of Public Health
https://www.readbyqxmd.com/read/29618365/apolipoprotein-e4-impairs-spontaneous-blood-brain-barrier-repair-following-traumatic-brain-injury
#15
Bevan S Main, Sonia Villapol, Stephanie S Sloley, David J Barton, Maia Parsadanian, Chinyere Agbaegbu, Kathryn Stefos, Mondona S McCann, Patricia M Washington, Olga C Rodriguez, Mark P Burns
BACKGROUND: Traumatic Brain Injury (TBI) is a major cause of disability and mortality, to which there is currently no comprehensive treatment. Blood Brain Barrier (BBB) dysfunction is well documented in human TBI patients, yet the molecular mechanisms that underlie this neurovascular unit (NVU) pathology remains unclear. The apolipoprotein-E (apoE) protein has been implicated in controlling BBB integrity in an isoform dependent manner, via suppression of Cyclophilin A (CypA)-Matrix metallopeptidase-9 (MMP-9) signaling cascades, however the contribution of this pathway in TBI-induced BBB permeability is not fully investigated...
April 4, 2018: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/29617695/topical-treatment-of-skin-injury-inflicted-in-mice-by-x-ray-irradiation
#16
Evangelia Meimeti, Antonios Kafanas, Panagoula Pavlou, Antonia Evangelatou, Panagiota Tsouparelou, Stelios Kanellopoulos, Panagiotis Kipouros, Nikolaos Koliarakis, Georgios Leonis, Efstathia Ioannou, Vassilios Roussis, Michail Rallis
BACKGROUND/AIMS: There is no treatment, without side effects, efficiently preventing or curing skin burns, caused by radiotherapy. A new experimental topical treatment protocol was assessed in mice receiving orthovoltage X-rays at an equivalent dose to that applied to human breast cancer patients in conventional radiotherapy. METHODS: SKH-HR2 female hairless mice were irradiated on their dorsum with a total dose of 4,300 cGy during a 1-month period (20 fractions)...
April 4, 2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29615112/where-to-from-here-a-quality-improvement-project-investigating-burns-treatment-and-rehabilitation-practices-in-india
#17
J Jagnoor, C Lukaszyk, A Christou, T Potokar, S Chamania, R Ivers
OBJECTIVE: To describe the capacity of the Indian healthcare system in providing appropriate and effective burns treatment and rehabilitation services. RESULTS: Health professionals involved in burns treatment or rehabilitation at seven hospitals from four states in India were invited to participate in consultative meetings. Existing treatment and rehabilitation strategies, barriers and enablers to patient flow across the continuum of care and details on inpatient and outpatient rehabilitation were discussed during the meetings...
April 3, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29609856/a-polymicrobial-fungal-outbreak-in-a-regional-burn-center-after-hurricane-sandy
#18
Geeta Sood, Dhananjay Vaidya, Lisa Dam, Lisa M Grubb, Jonathan Zenilman, Kelly Krout, Zeina Khouri-Stevens, Richard Bennett, Renee Blanding, Stefan Riedel, Stephen Milner, Leigh Ann Price, Trish M Perl
OBJECTIVE: To describe a polymicrobial fungal outbreak after Hurricane Sandy. DESIGN: An observational concurrent outbreak investigation and retrospective descriptive review. SETTING: A regional burn intensive care unit that serves the greater Baltimore area, admitting 350-450 burn patients annually. PATIENTS: Patients with burn injuries and significant dermatologic diseases such as toxic epidermal necrolysis who were admitted to the burn intensive care unit...
March 30, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29609283/-wet-cement-skin-burns
#19
Z H Long, W G Xie
Under certain condition, wet cement can cause skin chemical burns, which belongs to alkaline burns. As the symptoms are insidious in onset, the patients may be initially unaware of the injury until several hours later. It often causes full-thickness burns especially in knees, the lower limbs, and ankles. The prevalence of wet cement burns may be hugely underestimated. This article reviews the definition, occurrence, progress of injury and pathogenesis, clinical characteristics and diagnosis, and treatment and prevention of wet cement skin burns, in order to promote its prevention...
March 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29609280/-advances-in-the-research-of-relationship-between-brown-or-beige-fat-and-hypermetabolism-after-severe-burn
#20
M Zhang, Y Liu, X Zhang
Hypermetabolism is one of the remarkable characteristics of burn injury. Prolonged hypermetabolism causes insufficient energy supply, which leads to delayed wound healing, immune system dysfunction, increased infection rate, and multi-organ failure. In recent years, it is concerned that the activation of brown or beige adipose tissue may be related to hypermetabolism in severe burn patients. Brown or beige adipose tissue could be regulated by stress hormones and some cytokines which increase and persist in high level for several months after severe burn...
March 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
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