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Burn Injury

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https://www.readbyqxmd.com/read/28727221/scar-formation-following-excisional-and-burn-injuries-in-a-red-duroc-pig-model
#1
Britani N Blackstone, Jayne Y Kim, Kevin L McFarland, Chandan K Sen, Dorothy M Supp, J Kevin Bailey, Heather M Powell
Scar research is challenging because rodents do not naturally form excessive scars, and burn depth, size, and location cannot be controlled in human longitudinal studies. The female, red Duroc pig model has been shown to form robust scars with biological and anatomical similarities to human hypertrophic scars. To more closely mimic the mode of injury, recreate the complex chemical milieu of the burn wound environment and enhance scar development, an animal model of excessive burn-induced scarring was developed and compared with the more commonly used model, which involves excisional wounds created via dermatome...
July 20, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28727215/neutrophil-extracellular-traps-coincide-with-a-pro-coagulant-status-of-microcirculatory-endothelium-in-burn-wounds
#2
H Ibrahim Korkmaz, Magda M W Ulrich, Sanne Vogels, Tim de Wit, Paul P M van Zuijlen, Paul A J Krijnen, Hans W M Niessen
Burn-induced tissue loss is partly related to secondary expansion of necrosis into vital dermis neighbouring the initial burn injury. An important factor herein is the severe loss of perfusion of the burn wound, probably caused by microvascular damage induced by the intense local inflammatory responses as well as burn-induced hypercoagulation. We hypothesize that the formation of Neutrophilic Extracellular Traps (NETs) play an important role in this. The purpose of this study was to investigate post-burn intravascular thrombosis, NETs formation and the coagulant state in the microvasculature of burns in both animal models and patients...
July 20, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28727180/why-was-a-local-anaesthetic-used-before-administering-intranasal-ketamine-for-paediatric-injuries
#3
Sabine Lemoine, Daniel Jost, Kilian Bertho, Jean Pierre Tourtier
We were very interested to read Scheier et al's brief report on the use of intranasal ketamine in their pediatric emergency department, specifically for pain and anxiety in children who had resisted venipuncture or intravenous placement (1). Intravenous access can be difficult for pre-hospital medical teams that are not specialised in paediatric care, namely when children complain of pain from, for example suspected fractures and burns. This article is protected by copyright. All rights reserved.
July 20, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28725843/identifying-and-understanding-the-health-information-experiences-and-preferences-of-individuals-with-tbi-sci-and-burn-injuries
#4
Nathan T Coffey, Ali A Weinstein, Cindy Cai, Jimmy Cassese, Rebecca Jones, Dahlia Shaewitz, Steven Garfinkel
INTRODUCTION: Traumatic brain injury, spinal cord injury, and burn injury can cause lifelong disability and changes in quality of life. In order to meet the challenges of postinjury life, various types of health information are needed. We sought to identify preferred sources of health information and services for persons with these injuries and discover how accessibility could be improved. METHODS: Thirty-three persons with injury participated in semistructured interviews...
September 2016: Journal of patient experience
https://www.readbyqxmd.com/read/28723881/correlation-between-pao2-fio2-and-peripheral-capillary-oxygenation-fio2-in-burned-children-with-smoke-inhalation-injury
#5
Janos Cambiaso-Daniel, Charles D Voigt, Eric Rivas, Gabriel Hundeshagen, Omar Nunez-Lopez, Lars-Peter Kamolz, Michaela Sljivich, Linda E Sousse, David N Herndon, Oscar E Suman, Michael P Kinsky, Ronald P Mlcak
OBJECTIVES: Determine whether the peripheral capillary oxygenation/FIO2 ratio correlates with the PaO2/FIO2 ratio in burned children with smoke inhalation injury, with the goal of understanding if the peripheral capillary oxygenation/FIO2 ratio can serve as a surrogate for the PaO2/FIO2 ratio for the diagnosis of acute respiratory distress syndrome. DESIGN: Retrospective chart review. SETTING: Shriners Hospitals for Children-Galveston. PATIENTS: All burned children with smoke inhalation injury who were admitted from 1996 to 2014 and had simultaneously obtained peripheral capillary oxygenation, FIO2 and PaO2 measurements...
July 18, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28723751/early-laparotomy-and-timely-reconstruction-for-patients-with-abdominal-electrical-injury-five-case-reports-and-literature-review
#6
Pi-Hong Zhang, Zan Liu, Li-Cheng Ren, Ji-Zhang Zeng, Geng-Wen Huang, Mu-Zhang Xiao, Jie Zhou, Peng-Fei Liang, Ming-Hua Zhang, Xiao-Yuan Huang
INTRODUCTION: High-tension electricity can cause devastating injuries that may result in abdominal wall loss, visceral damage, and sometimes major threat to life. The visceral organ may be exposed after debridement and require flap cover, but the tensile strength of abdominal wall may be lack even if flap transplanted. METHODS: From April 2007 through May 2015, 5 patients with severe abdominal electrical injury were treated at our hospital. Exploratory laparotomy was performed based on their clinical manifestations and debridement findings of abdominal wall at early stage, and decision regarding technique for reconstruction of abdominal wall was based on an assessment of the location and extent of the defect...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28720396/pituitary-adenylate-cyclase-activating-polypeptide-pacap-protects-against-mitoxantrone-induced-cardiac-injury-in-mice
#7
Venkat Subramaniam, Gin Chuang, Huijing Xia, Brendan Burn, Jessica Bradley, Jerome L Maderdrut, David H Coy, Kurt J Varner
Mitoxantrone (MXT) is an androstenedione that is used to treat cancers and progressive forms of multiple sclerosis; however, its use is limited by its cardiotoxicity. Pituitary adenylate cyclase activating polypeptide (PACAP) is a member of the secretin/growth hormone-releasing hormone/vasoactive intestinal peptide family and has many functions, including cytoprotection and immunosuppression. We tested the hypothesis that PACAP can protect against MXT-induced cardiotoxicity in mice. Female BALB/c mice were treated once weekly for 4 weeks with saline (n=14) or MXT (3mg/kg, i...
July 15, 2017: Peptides
https://www.readbyqxmd.com/read/28719379/critical-evaluation-of-metallization-in-electric-injury
#8
Sigitas Laima, Jana Bytautaite, Sigitas Chmieliauskas, Dmitrij Fomin, Algimantas Jasulaitis, Arturas Jukna, Sandra Mazeikiene, Jurgita Stasiuniene
The article presents 3 forensic medicine cases in the field of electric injury. In addition to traditional findings in electric injury (electric mark and histological findings), the forensic medicine experts in Lithuania also perform an atomic absorption spectrometry analysis. This method confirms the effects of electric current to the body through the electric conductor. Typical macroscopic finding in the skin is electric mark. Histologically, the damaged skin possesses characteristic features of thermal burns...
July 18, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28718941/child-understandings-of-the-causation-of-childhood-burn-injuries-child-activity-parental-domestic-demands-and-impoverished-settings
#9
N Titi, A van Niekerk, R Ahmed
BACKGROUND: Burns are a global public health problem. In South Africa, the rate of paediatric burn deaths is 5 times higher than other upper middle-income countries, with concentrations in impoverished settings. Globally, the majority of research focuses on expert and caregiver descriptions of burn occurrence, causation, and prevention, with limited consideration of children's perspectives. This study investigated children's understanding of the causation and prevention of childhood burns...
July 18, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28717655/the-neck-burn-scar-contracture-a-concept-of-effective-treatment
#10
REVIEW
Sadanori Akita, Kenji Hayashida, Satoshi Takaki, Yoshihisa Kawakami, Takuto Oyama, Hiroyuki Ohjimi
A neck scar contracture can severely and negatively affect the function of mastication, phonic, or breathing and result in neck pain and issues with esthetics. The best way is of course to avoid such contracture by means of non-surgical treatment such as use of a growth factor. The basic fibroblastic growth factor is clinically well proven in decreasing scar formation and improving healing. There are numerous reconstructive methods for neck contracture, especially when the lesions are relatively limited in part of the neck...
2017: Burns and trauma
https://www.readbyqxmd.com/read/28716552/is-heterotopic-ossification-getting-nervous-the-role-of-the-peripheral-nervous-system-in-heterotopic-ossification
#11
Eleanor L Davis, Alan R Davis, Zbigniew Gugala, Elizabeth A Olmsted-Davis
Heterotopic ossification (HO), or de novo bone formation in soft tissue, is often observed following traumatic injury. Recent studies suggest that peripheral nerves may play a key functional role in this process. The results supporting a neurological basis for HO are examined in this article. Evidence supports the fact that BMPs released from bone matrix possess the capacity to induce HO. However, the process cannot be recapitulated using recombinant proteins without extremely high doses suggesting other components are required for this process...
July 14, 2017: Bone
https://www.readbyqxmd.com/read/28716352/fatal-and-non-fatal-injury-outcomes-results-from-a-purposively-sampled-census-of-seven-rural-subdistricts-in-bangladesh
#12
Olakunle Alonge, Priyanka Agrawal, Abu Talab, Qazi S Rahman, Akm Fazlur Rahman, Shams El Arifeen, Adnan A Hyder
BACKGROUND: 90% of the global burden of injuries is borne by low-income and middle-income countries (LMICs). However, details of the injury burden in LMICs are less clear because of the scarcity of data and population-based studies. The Saving of Lives from Drowning project, implemented in rural Bangladesh, did a census on 1·2 million people to fill this gap. This Article describes the epidemiology of fatal and non-fatal injuries from the study. METHODS: In this study, we used data from the baseline census conducted as part of the Saving of Lives from Drowning (SoLiD) project...
August 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28716301/discrete-%C3%AE-adrenergic-mechanisms-regulate-early-and-late-erythropoiesis-in-erythropoietin-resistant-anemia
#13
Shirin Hasan, Michael J Mosier, Andrea Szilagyi, Richard L Gamelli, Kuzhali Muthumalaiappan
BACKGROUND: Anemia of critical illness is resistant to exogenous erythropoietin. Packed red blood cells transfusions is the only treatment option, and despite related cost and morbidity, there is a need for alternate strategies. Erythrocyte development can be divided into erythropoietin-dependent and erythropoietin-independent stages. We have shown previously that erythropoietin-dependent development is intact in burn patients and the erythropoietin-independent early commitment stage, which is regulated by β1/β2-adrenergic mechanisms, is compromised...
July 14, 2017: Surgery
https://www.readbyqxmd.com/read/28715585/retinoic-acid-engineered-amniotic-membrane-used-as-graft-or-homogenate-positive-effects-on-corneal-alkali-burns
#14
Romain Joubert, Estelle Daniel, Nicolas Bonnin, Aurélie Comptour, Christelle Gross, Corinne Belville, Frédéric Chiambaretta, Loïc Blanchon, Vincent Sapin
Purpose: Alkali burns are the most common, severe chemical ocular injuries, their functional prognosis depending on corneal wound healing efficiency. The purpose of our study was to compare the benefits of amniotic membrane (AM) grafts and homogenates for wound healing in the presence or absence of previous all-trans retinoic acid (atRA) treatment. Methods: Fifty male CD1 mice with reproducible corneal chemical burn were divided into five groups, as follows: group 1 was treated with saline solution; groups 2 and 3 received untreated AM grafts or grafts treated with atRA, respectively; and groups 4 and 5 received untreated AM homogenates or homogenates treated with atRA, respectively...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28714163/occupational-therapists-role-in-facilitating-pain-management-in-children-with-burn-injuries
#15
Belinda Kipping, Kate Miller
No abstract text is available yet for this article.
July 2017: Australian Occupational Therapy Journal
https://www.readbyqxmd.com/read/28713711/the-role-of-human-adult-peripheral-and-umbilical-cord-blood-platelet-rich-plasma-on-proliferation-and-migration-of-human-skin-fibroblasts
#16
Seyedeh-Sara Hashemi, Mahdokht Mahmoodi, Ali Reza Rafati, Farzad Manafi, Davood Mehrabani
BACKGROUND: Wound healing is a complex and dynamic process following damage in tissue structures. Due to extensive skin damage caused by burn injuries, this study determined the role of human adult peripheral and umbilical cord blood platelet-rich plasma on proliferation and migration in human skin fibroblasts. METHODS: Platelet-rich plasma (5, 10, 15, 20 and 50% PRP) from human umbilical cord blood and adult peripheral blood were provided and added to fibroblasts cultured from a human skin sample...
May 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28713707/epidemiology-of-acid-burns-in-a-major-referral-hospital-in-tehran-iran
#17
Reza Vaghardoost, Jafar Kazemzadeh, Mostafa Dahmardehei, Soheila Rabiepoor, Ramyar Farzan, Ali Asghar Kheiri, Rahman Khosravy, Farzad Manafi
BACKGROUND: Most of the acid- burns are due to assault or accidental. The epidemiology of burns is diverse across the world and within a country. We evaluated the epidemiology and outcome of acid-burns in tertiary health care center in Tehran, Iran. METHODS: This study was retrospective descriptive among patients referred for acid-burn injury that was done in a referral Burn Care Center in Tehran, Iran, during a ten-year period since 2005 to 2014. Patient's data collected by a specially designed check list...
May 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28712732/burn-center-care-reduces-acute-health-care-utilization-after-discharge-a-population-based-analysis-of-1-895-survivors-of%C3%A2-major-burn-injury
#18
Stephanie A Mason, Avery B Nathens, James P Byrne, Robert A Fowler, Paul J Karanicolas, Rahim Moineddin, Marc G Jeschke
BACKGROUND: Improvements in survival after burns have resulted in more patients being discharged home after severe injury. However, the postdischarge health care needs of burn survivors are not well understood. We aimed to determine the rate and causes of unplanned presentation to acute care facilities in the 5 years after major burn injury. METHODS: Data derived from several population-based administrative databases were used to conduct a retrospective cohort study...
July 13, 2017: Surgery
https://www.readbyqxmd.com/read/28711594/hepatic-mitochondrial-bioenergetics-in-aged-c57bl-6-mice-exhibit-delayed-recovery-from-severe-burn-injury
#19
Christopher Auger, Thibacg Sivayoganathan, Abdikarim Abdullahi, Alexandra Parousis, Marc G Jeschke
Severe burn injuries initiate a cascade of downstream events, culminating in multiple organ dysfunction, sepsis, and even death. The elderly are in particular vulnerable to such outcomes, due primarily to a scarcity of knowledge on trauma progression at the biomolecular level in this population. Mitochondria, the cellular powerhouses, have been increasingly scrutinized recently for their contribution to trauma outcomes. We hypothesized that elderly have a worse outcome compared to adult patients due to failed recovery of hepatic mitochondria...
July 12, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28711375/the-prevalence-of-orodental-trauma-during-epileptic-seizures-in-terms-of-dental-treatment-survey-study
#20
Dominika Gawlak, Joanna Łuniewska, Wiktoria Stojak, Anahit Hovhannisyan, Anna Stróżyńska, Katarzyna Mańka-Malara, Marcin Adamiec, Andrzej Rysz
INTRODUCTION: Epilepsy is one of the most common neurological disorders. Seizures that occur during attacks may lead to head injuries. It is crucial to establish proper prophylactic management against trauma occurrence, as nowadays prevention is not sufficient. AIM: Assessment of the frequency of head and intraoral trauma during epileptic seizures and to evaluate factors that may predispose to injuries. MATERIAL AND METHODS: The questionnaire was carried out among 106 patients with epilepsy...
June 29, 2017: Neurologia i Neurochirurgia Polska
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