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Keywords Lupus SLE systemic leukocytocl...

Lupus SLE systemic leukocytoclastic vasculitis

https://read.qxmd.com/read/37853861/a-case-of-palisaded-neutrophilic-and-granulomatous-dermatitis-associated-with-an-initial-presentation-in-ankylosing-spondylitis
#1
Young Sun Suh, Eui Chang Jung, Yun Sun Moon, Seung-Geun Lee, Hyun-Ok Kim
Palisaded neutrophilic and granulomatous dermatitis (PNGD) is an inflammatory dermatosis associated with systemic immune-mediated diseases such as rheumatoid arthritis, systemic sclerosis, lupus erythematosus, and ulcerative colitis. Histologically, serial development of leukocytoclastic vasculitis is shown from an early stage, which can progress to palisading granuloma in the fully developed stage and to fibrosis in the final stage. A 32-year-old man presented with ankylosing spondylitis showing multiple erythematous papules on his fingers, elbows, knees, and left auricle...
May 2023: Annals of Dermatology
https://read.qxmd.com/read/37476529/tumor-like-presentation-of-cerebral-vasculitis-in-a-patient-with-systemic-lupus-erythematosus-a-biopsy-confirmed-case
#2
Na Ri Kim, Jong Wan Kang, Eon Jeong Nam
Central nervous system (CNS) manifestations of systemic lupus erythematosus (SLE) are diverse and often difficult to distinguish from SLE-unrelated events. CNS vasculitis is a rare manifestation, which is seen in less than 10% of post-mortem studies, and lesions with multifocal cerebral cortical microinfarcts associated with small-vessel vasculitis are the predominant feature. However, CNS vasculitis presenting as a tumor-like mass lesion in SLE has rarely been reported. Herein, we report a case of cerebral vasculitis mimicking a brain tumor in a 39-year-old female with SLE...
January 1, 2023: Journal of rheumatic diseases
https://read.qxmd.com/read/37401805/azathioprine-hypersensitivity-a-sweet-like-syndrome
#3
Lokesh Koumar Sivanandam, Benazir Begum, Ernesto Calderon Martinez, Sushmita Garikipati, Vivek Sanker, Abdelmonem Siddiq
INTRODUCTION: Azathioprine hypersensitivity can occasionally present as Sweet-like syndrome, a dose-independent side effect characterized by the unanticipated onset of macules, papules, and pustules. CASE PRESENTATION: A 35-year-old woman with systemic lupus erythematosus presented with complaints of generalized maculopapular rash, facial swelling, and bilateral lower extremity edema with a duration of 4 days and a 2-day history of constitutional symptoms within 2 weeks of the beginning of azathioprine therapy to treat existing lupus nephritis (class 2/3)...
July 4, 2023: International Journal of Rheumatic Diseases
https://read.qxmd.com/read/37218538/autoimmune-skin-disorders-and-sars-cov-2-vaccination-a-meta-analysis
#4
JOURNAL ARTICLE
Julia Hinterseher, Michael Hertl, Dario Didona
BACKGROUND AND OBJECTIVES: The coronavirus SARS-CoV-2, which is the cause of COVID-19 disease in infected patients, has led to an ongoing worldwide pandemic. Although SARS-CoV-2 vaccination had a dramatic positive effect on the course of COVID-19, there has been increasing evidence of adverse effects after SARS-CoV-2 vaccination. This meta-analysis highlights the association between SARS-CoV-2 vaccination and de novo induction or aggravation of inflammatory and autoimmune skin diseases...
May 23, 2023: Journal der Deutschen Dermatologischen Gesellschaft: JDDG
https://read.qxmd.com/read/37033559/chorea-as-a-manifestation-of-systemic-lupus-erythematosus
#5
Teresa Medeiros, Andreia Vilas-Boas, Vanessa Carvalho, Teresa Santos, Ana Pinho
Systemic lupus erythematosus (SLE) is an autoimmune disease with multisystemic manifestations, including central nervous system involvement. Chorea is a hyperkinetic movement disorder, characterized by involuntary, dance-like and poorly coordinated movements. Acute-onset chorea is a rare neuropsychiatric inaugural manifestation of SLE. This presentation is frequently associated with positive antiphospholipid antibodies, and it usually improves with immunosuppressive treatment. We report the case of a 20-year-old female, who presented with acute onset left hemichorea and fever...
March 2023: Curēus
https://read.qxmd.com/read/36644011/chronic-recurrent-wheals-if-not-chronic-spontaneous-urticaria-what-else
#6
REVIEW
Hanna Bonnekoh, Karoline Krause, Pavel Kolkhir
Chronic urticarial rash, mostly due to chronic spontaneous urticaria (CSU), is seen in up to 1 - 4% of the general population. Urticarial vasculitis (UV) and autoinflammatory syndromes, i.e., cryopyrin-associated periodic syndromes (CAPS) and Schnitzler syndrome (SchS), can mimic CSU-like rash but represent rare disorders with systemic symptoms including fever, headache, conjunctivitis, and arthralgia. Clinical and laboratory features can point to the presence of any of these diseases in patients initially presenting with chronic urticarial rash...
2023: Allergologie Select
https://read.qxmd.com/read/36502957/cutaneous-leukocytoclastic-vasculitis-as-the-presenting-sign-of-systemic-lupus-erythematosus
#7
JOURNAL ARTICLE
Bianca Biglione, Connie Zhong, Christopher Iriarte, Bethany Cucka, Mai P Hoang, Daniela Kroshinsky
No abstract text is available yet for this article.
December 8, 2022: American Journal of Medicine
https://read.qxmd.com/read/36197426/leukocytoclastic-vasculitis-in-a-patient-with-syphilis-and-hiv-coinfection
#8
Nicolás Ariza Ordoñez, Valeria Gómez Sepúlveda, Antonia Pino Marín, Lina Patricia Vargas Nieto, Julián Moreno León, Henry Augusto Millán Prada
Leukocytoclastic vasculitis (LCV) is a small vessel vasculitis characterized by an inflammatory infiltrate composed of neutrophils with fibrinoid necrosis and "leukocytoclasia", a term that refers to nuclei disintegration into fragments. LCV is related to multiple conditions including ANCA-associated vasculitis, cryoglobulinemia, IgA vasculitis, infectious and systemic diseases such as rheumatoid arthritis and systemic erythematous lupus (SLE) as well as infections and malignancy. We describe the clinical case of severe systemic vasculitis in a young male patient with secondary syphilis and HIV coinfection manifested by cutaneous and neurological involvement, as well as peripheral necrosis that requires bilateral lower limb amputation...
2022: Revista do Instituto de Medicina Tropical de São Paulo
https://read.qxmd.com/read/35989318/correct-approach-in-urticarial-vasculitis-made-early-diagnosis-of-lupus-nephritis-possible-a-case-report
#9
JOURNAL ARTICLE
Kyra Smets, Anne Van Baelen, Ben Sprangers, Petra De Haes
BACKGROUND: Urticarial vasculitis is a clinicopathologic entity defined by recurrent episodes of urticarial lesions that persist > 24 hours and demonstrate the histopathologic features of leukocytoclastic vasculitis. The most important prognostic feature is the presence of normo- or hypocomplementemia. In the latter, patients are much more likely to have systemic manifestations. Urticarial vasculitis is most often idiopathic, but it can arise in association with autoimmune connective diseases, cryoglobulinemia, infections, medications, and hematologic malignancies...
August 22, 2022: Journal of Medical Case Reports
https://read.qxmd.com/read/35907580/leukocytoclastic-vasculitis-in-association-with-linear-epidermal-basement-membrane-zone-immunoglobulin-deposition-linear-vasculitis
#10
JOURNAL ARTICLE
Cynthia M Magro, Joshua H Mo, Mary Jo Kerns
Cutaneous leukocytoclastic vasculitis (LCV) has a distinctive clinical and light microscopic presentation; however, the etiologic basis of LCV is varied. Most cases are attributable to immune complex deposition within a vessel wall and represent an Arthus type III immune complex reaction. The prototypic immunoreactant profile is characterized by granular deposits of components of complement activation in concert with immunoglobulin within the cutaneous vasculature. We encountered nine patients with vasculitic and/or vesiculobullous clinical presentations exhibiting an LCV in association with an immunoreactant profile characterized by homogeneous linear deposits of immunoglobulin along the dermal epidermal junction in a fashion resembling an autoimmune vesiculobullous disease...
2022: Clinics in Dermatology
https://read.qxmd.com/read/34720919/a-case-of-systemic-lupus-erythematosus-with-cutaneous-leukocytoclastic-vasculitis-mimicking-bullous-sle
#11
Fumi Miyagawa, Kohei Ogawa, Takashi Hashimoto, Hideo Asada
Rarely, patients with systemic lupus erythematosus (SLE) develop bullous eruptions, a disease called bullous SLE in a narrow sense that has autoantibodies against type VII collagen. We describe an unusual case in which a patient with SLE developed extensive bullae on her lower extremities. Histologically, the bullous lesions were suggestive of leukocytoclastic vasculitis with deposition of C3 within blood vessel walls. Immunoblot analyses and enzyme-linked immunosorbent assays were negative for anti-type VII collagen antibodies...
September 2021: Case Reports in Dermatology
https://read.qxmd.com/read/34201078/histologic-patterns-and-clues-to-autoinflammatory-diseases-in-children-what-a-cutaneous-biopsy-can-tell-us
#12
REVIEW
Athanassios Kolivras, Isabelle Meiers, Ursula Sass, Curtis T Thompson
Autoinflammation is defined by aberrant, antigen-independent activation of the innate immune signaling pathways. This leads to increased, pro-inflammatory cytokine expression and subsequent inflammation. In contrast, autoimmune and allergic diseases are antigen-directed immune responses from activation of the adaptive immune system. The innate and adaptive immune signaling pathways are closely interconnected. The group of 'complex multigenic diseases' are a result of mutual dysregulation of both the autoinflammatory and autoimmune physiologic components...
June 8, 2021: Dermatopathology (Basel, Switzerland)
https://read.qxmd.com/read/34176492/a-young-girl-with-chronic-isolated-cervical-lymphadenopathy-found-to-have-lupus-lymphadenopathy-progressing-to-develop-lupus-nephritis-a-case-report
#13
JOURNAL ARTICLE
K P Jayawickreme, S Subasinghe, S Weerasinghe, L Perera, P Dissanayaka
BACKGROUND: Systemic lupus erythematosus is a rare autoimmune disorder, with the prevalence in Asia ranging from 30 to 50/100,000. The diagnosis of systemic lupus erythematosus is made according to the 2019 European League Against Rheumatism/American College of Rheumatology classification criteria, and it does not contain lymphadenopathy as diagnostic criteria. However, lupus lymphadenopathy has an estimated prevalence of 5-7% at the onset of disease, and 12-15% at any stage of the disease...
June 28, 2021: Journal of Medical Case Reports
https://read.qxmd.com/read/33911815/palisaded-neutrophilic-and-granulomatous-dermatitis-in-a-patient-with-beh%C3%A3-et-s-disease-a-case-report
#14
Young-Bin Shin, Jeong-Won Jo, Tae-Jin Yoon
Palisaded neutrophilic and granulomatous dermatitis (PNGD) is an uncommon skin eruption and characterized histopathologically by the presence of granulomatous inflammation with or without leukocytoclastic vasculitis. PNGD is known to be associated with various immune-mediated connective tissue diseases such as rheumatoid arthritis and lupus erythematosus. However, to our knowledge, a case of PNGD in a patient with Behçet's disease is extremely rare and only one case has been reported in foreign literature to date...
February 2021: Annals of Dermatology
https://read.qxmd.com/read/33747647/schnitzler-syndrome-a-recherche-entity
#15
Rajesh Kumar, Anupama Behera, Ratul Seal, Subhabrata Patra
Schnitzler syndrome (SS) is a rare disease of unknown etiology. Literature suggests that only around 300 well-diagnosed cases have only been reported worldwide and rarely from India. This syndrome has a slight male predominance with a mean age of onset of around 50 years. It is considered an autoinflammatory disease with presentation mimicking adult-onset Still's disease and systemic lupus erythematosus, and its presentation most commonly includes recurrent fever, urticarial rash, arthralgia, and bone pains...
February 14, 2021: Curēus
https://read.qxmd.com/read/33505756/a-case-of-systemic-lupus-erythematosus-and-antineutrophil-cytoplasmic-antibodies-associated-vasculitis-overlap-syndrome
#16
Hiroyuki Hounoki, Koichiro Shinoda, Atsushi Matsui, Maiko Okumura, Satoshi Yamaguchi, Kota Kakeshita, Hidenori Yamazaki, Tsutomu Koike, Teruhiko Makino, Kazuyuki Tobe
An overlap of systemic lupus erythematosus (SLE) and antineutrophil cytoplasmic antibodies- (ANCA-) associated vasculitis (AAV) is extremely rare: approximately 40 cases have been reported to date. A literature review indicates that they are more common in women in their forties, and simultaneous onset has been reported in 69% of cases. In addition, both lupus nephritis and ANCA-associated glomerulonephritis were observed on renal biopsy. This report presents the case of a 35-year-old woman with an 8-month history of polyarthralgia who was admitted to our hospital...
2021: Case Reports in Rheumatology
https://read.qxmd.com/read/33192108/successful-treatment-of-urticarial-vasculitis-in-a-patient-with-systemic-lupus-erythematosus-with-rituximab
#17
Samar Alharbi, Jorge Sanchez-Guerrero
Urticarial vasculitis is an eruption of erythematous wheals that clinically resemble urticaria but histologically show changes of leukocytoklastic vasculitis. In association with connective tissue disease it is most commonly seen complicating Systemic lupus erythematous (SLE) and, less often, Sjogren's syndrome. Here, we report a 25-year-old woman who developed SLE in 1998. In May 2013 she presented with urticarial vasculitis; her skin biopsy was consistent with leukocytoclastic vasculitis. She also developed bilateral uveitis...
2020: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://read.qxmd.com/read/32762386/leukocytoclastic-vasculitis-as-the-presenting-symptom-of-crohn-s-disease-in-an-adolescent
#18
JOURNAL ARTICLE
Vanessa Ford, Cassandra Mooney, Meera Shah, Elan Jenkins
Leukocytoclastic vasculitis (LCV) is a rare vascular inflammatory condition that affects post-capillary venules. Its incidence in the pediatric population is unknown. However, its incidence has been shown to increase with age. The causes of LCV can be varied, ranging from drugs to infections to systemic disease. LCV as a presenting symptom of inflammatory bowel disease (IBD) is rare, especially in the pediatric population. A 15-year-old female with a family history of systemic lupus erythematosus was transferred to our hospital with a month-long history of rash, joint swelling and tenderness, periorbital edema, weight loss, and diarrhea...
January 2020: Journal of Investigative Medicine High Impact Case Reports
https://read.qxmd.com/read/32493024/secondary-vasculitis-omitted-manifestation-of-many-diseases
#19
JOURNAL ARTICLE
Radim Bečvář
Secondary vasculitides usually accompany various common and rare conditions, Their clinical picture is very diverse, they can be loclaized or genaralized. Most frequently, we find parainfectious, drug-related and paraneoplastic vasculitides, less commonly in connective tissue diseases, after radiotherapy or transplantation. Vasculitides may be associated to infection of any origin. Drug-related vasculitides are mainly confined to the skin with picture of leukocytoclastic angiitis but visceral organs may be involved too...
2020: Ceskoslovenská Patologie
https://read.qxmd.com/read/32180892/management-of-urticarial-vasculitis-a-worldwide-physician-perspective
#20
JOURNAL ARTICLE
Pavel Kolkhir, Hanna Bonnekoh, Emek Kocatürk, Michihiro Hide, Martin Metz, Mario Sánchez-Borges, Karoline Krause, Marcus Maurer
BACKGROUND: Urticarial vasculitis (UV) is a rare type of leukocytoclastic vasculitis characterized by long lasting urticarial skin lesions and poor response to treatment. As of yet, no clinical guidelines, diagnostic criteria, or treatment algorithms exist, and the approaches to the diagnostic workup and treatment of UV patients may differ globally. We conducted an online survey to examine how UV patients are diagnosed and treated by international specialists and to reveal the greatest challenges in managing UV patients worldwide...
March 2020: World Allergy Organization Journal
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