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Neurologic lupus SLE

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https://www.readbyqxmd.com/read/27887767/vascular-endothelial-growth-factor-g1612a-rs10434-gene-polymorphism-and-neuropsychiatric-manifestations-in-systemic-lupus-erythematosus-patients
#1
Sherif Taha, Sherif Mohammed Gamal, Mohamed Nabil, Nahla Naeem, Dalia Labib, Ibrahim Siam, Tamer Atef Gheita
AIM: To investigate the relation between vascular endothelial growth factor (VEGF) gene polymorphism in systemic lupus erythematosus (SLE) patients and lupus related neuropsychiatric manifestations. PATIENTS AND METHODS: Sixty adult SLE patients recruited from the Rheumatology and Neurology departments of Cairo University hospitals were classified into two groups; Group A: 30 patients with neuropsychiatric manifestations (NPSLE) and Group B: 30 patients without...
October 28, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27862544/brain-morphology-and-cortical-thickness-variations-in-systemic-lupus-erythematosus-patients-differences-among-neurological-psychiatric-and-nonneuropsychiatric-manifestations
#2
Nicolle Zimmermann, Diogo Goulart Corrêa, Gustavo Tukamoto, Tania Netto, Denis Batista Pereira, Rochele Paz Fonseca, Emerson Leandro Gasparetto
PURPOSE: To determine whether systemic lupus erythematosus (SLE) affecting subcortical white matter volumes, deep gray matter volumes, and cortical thickness differ between groups of SLE patients with psychiatric (P-SLE), neurological (N-SLE), or nonneuropsychiatric (non-NPSLE) presentations. MATERIALS AND METHODS: Sixty-seven participants were divided into three groups (P-SLE [n = 19], N-SLE [n = 12], and non-NPSLE [n = 36]) and examined with a 1.5T MRI scanner...
November 8, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27848056/an-evaluation-of-health-related-quality-of-life-in-patients-with-systemic-lupus-erythematosus-using-promis-and-neuro-qol
#3
Jin-Shei Lai, Jennifer L Beaumont, Sally E Jensen, Karen Kaiser, David L Van Brunt, Amy H Kao, Shih-Yin Chen
Systemic lupus erythematosus (SLE) is a multi-organ chronic autoimmune disease that can negatively affect patients' health-related quality of life (HRQOL). This study evaluated HRQOL of SLE patients using questionnaires from the Patient-Reported Outcomes Measurement Information System (PROMIS) and Quality of Life in Neurological Disorders (Neuro-QoL). Individuals with SLE completed an online survey consisting of the PROMIS-29 health profile, PROMIS Psychosocial Illness Impact-Negative, and Neuro-QoL Applied Cognition...
November 15, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27799976/association-of-macrophage-activating-syndrome-with-castleman-s-syndrome-in-systemic-lupus-erythematosus
#4
Shamsa Shariatpanahi, Shahryar Pourfarzam, Mohammadhosein Gheini
Macrophage Activating Syndrome (MAS) is a life-threatening disease seen in autoimmune diseases including lupus erythematosus, rheumatoid arthritis, Still's disease, polyarteritis nodosa. It is characterized by fever, pancytopenia, liver failure, coagulopathy, and neurologic symptoms and high serum ferritin. A 27 yr. old female patient was admitted in shahid Mostafa Khomeini Hospital (Tehran-Iran) in May 2011 because of lower extremities edema and ascites and fever from 1.5 month ago. In physical examinations she had generalized lymphadenopathy, splenomegaly and pleural effusion...
2016: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/27746120/mr-diffusion-tractography-to-identify-and-characterize-microstructural-white-matter-tract-changes-in-systemic-lupus-erythematosus-patients
#5
RaviK Shastri, GaurangV Shah, Page Wang, Patricia Cagnoli, Tobias Schmidt-Wilcke, Joseph McCune, Richard Harris, PiaC Sundgren
PURPOSE: Systemic lupus erythematosus (SLE) is a predominantly female autoimmune disease that can affect the central nervous system. Neuropsychiatric symptoms are found in 25-70% of SLE patients. Using diffusion tensor imaging, various studies have reported changes in white matter integrity in SLE patients with neuropsychiatric symptoms (NPSLE patients). The purpose of this study was to investigate if changes can be detected in the individual white matter tracts in SLE patients regardless if neuropsychiatric symptoms are present or not...
November 2016: Academic Radiology
https://www.readbyqxmd.com/read/27744358/diagnosing-and-attributing-neuropsychiatric-events-to-systemic-lupus-erythematosus-time-to-untie-the-gordian-knot
#6
Sen Hee Tay, Anselm Mak
Neurological and psychiatric syndromes, collectively referred to as NPSLE, occur frequently in SLE. The frequency of NPSLE varies from 21 to 95%; however, only 13-38% of neuropsychiatric (NP) events could be attributable to SLE in the NPSLE SLICC inception cohort. This variability in the frequency of NPSLE is attributable to the low specificity of the ACR case definitions for SLE-attributed NP syndromes, inclusion of minor NP events in the ACR nomenclature, difficulty in ascertainment of NP events and diverse experience of rheumatologists in the clinical assessment of NP events...
October 15, 2016: Rheumatology
https://www.readbyqxmd.com/read/27666898/peripheral-neuropathy-in-systemic-lupus-erythematosus-clinical-and-electrophysiological-properties-and-their-association-with-disease-activity-parameters
#7
Renu Saigal, Rajat Bhargav, Laxmikant Goyal, Abhishek Agrawal, Pradeep Mital, Dileep Wadhwani
AIM: To study clinical and electrophysiological properties of peripheral neuropathy (PN) in systemic lupus erythematosus (SLE) and their association with disease activity parameters. METHODS: A hospital-based observational study done among 50 SLE patients after informed consent. History and clinical examination including a detailed neurological examination was carried out. Blood and urine investigation were done and modified SLE disease activity index (SLEDAI)-2000 score was calculated...
December 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27666897/sle-neuropathy-anything-new
#8
Vikram A Londhey
SLE (systemic lupus erythematosus) is a multisystem autoimmune disorder of unknown aetiology which can present with myriad clinical presentation. The neurological manifestations of SLE consist of central nervous system (CNS) and peripheral nervous system manifestations (PNS). The CNS manifestations are aseptic meningitis, cerebrovascular accidents (stroke), demyelinating disorders, headache, involuntary movements like chorea, myelopathy, acute confusional states, cognitive dysfunction, mood disorder, seizures, psychosis and cranial nerve palsies...
December 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27608785/guillain-barr%C3%A3-syndrome-systemic-lupus-erythematosus-and-acute-intermittent-porphyria-a-deadly-trio
#9
Ankita D Patil, Niteen D Karnik, Milind Y Nadkar, Vishal A Gupta, Krithika Muralidhara, Suresh Passidhi
Peripheral nervous system involvement occurs in 3-18% patients of systemic lupus erythematosus (SLE) cases. American College of Rheumatology (ACR) includes 19 neuropsychiatric syndromes for diagnosis of SLE divided into neurological syndromes of central, peripheral and autonomic nervous systems along with the psychiatric syndromes. Sensorimotor quadriparesis in a suspected case of SLE could be due to a Guillain Barré (GBS)-like illness, mononeuritis multiplex presenting as plexopathies, an anterior spinal artery syndrome or it can present like an acute transverse myelitis or hypokalemic periodic paralysis related to Sjogren's syndrome with renal tubular acidosis...
November 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27608700/systemic-lupus-erythematosus-presenting-as-neuroretinitis
#10
Gouranga Santra, Indrani Das
Neuroretinitis is the inflammation of retina and optic nerve. It is associated with optic disc edema accompanied by peripapillary or macular hard exudates. A 17 yr old female presented with headache and nausea of five days duration. She had periorbital edema and mild splenomegaly. Neurological assessment was non-contributory. She was found to have pancytopenia, albuminuria and a high ESR. Thereafter she developed blurring of vision of both eyes. Opthalmological examination showed it to be due to bilateral neuroretinitis...
October 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27590999/prognostic-significance-of-platelet-count-in-sle-patients
#11
Sahar Mahfouz Abdel Galil, Azzahra Mohammed Edrees, Afnan Khaled Ajeeb, Ghadeer Sameer Aldoobi, Mohamed El-Boshy, Waleed Hussain
Hematological abnormalities, especially thrombocytopenia (TCP), are highly prevalent among patients with systemic lupus erythematosus (SLE) and at the same time it has been reported as a significant prognostic factor of SLE course. We further investigate the correlation between platelet count and the clinical manifestations and disease activity of SLE, in a cohort of Saudi Arabian female patients. A retrospective analysis was done for the medical records of 100 SLE female patients, selected from all patients diagnosed and treated for SLE at the Rheumatology outpatient clinics in Hera'a General Hospital, Holly Makkah, Saudi Arabia...
September 2, 2016: Platelets
https://www.readbyqxmd.com/read/27538899/ganglionic-acetylcholine-receptor-autoantibodies-in-patients-with-autoimmune-diseases-including-primary-biliary-cirrhosis
#12
Yasuhiro Maeda, Shunya Nakane, Osamu Higuchi, Hideki Nakamura, Atsumasa Komori, Kiyoshi Migita, Akihiro Mukaino, Masataka Umeda, Kunihiro Ichinose, Mami Tamai, Shin-Ya Kawashiri, Waka Sakai, Hiroshi Yatsuhashi, Atsushi Kawakami, Hidenori Matsuo
OBJECTIVES: Autonomic dysfunction is closely associated with autoimmune diseases (AID) including primary biliary cirrhosis (PBC). The objective of this study was to determine the prevalence of anti-ganglionic (nicotinic) acetylcholine receptor (gAChR) antibodies in patients with AID. METHODS: We determined the presence of gAChR antibodies in serum samples from 146 patients (systemic lupus erythematosus [SLE] = 32; rheumatoid arthritis [RA] = 43; systemic sclerosis [SSc] = 38; PBC= 33) without information regarding autonomic symptoms, as well as 34 patients with other neurological diseases [OND], and 73 healthy controls [HC]...
September 30, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27432809/encephalopathy-with-upper-body-hypertonia-and-myoclonus-in-patient-with-systemic-lupus-erythematosus-and-anti-caspr2
#13
A Castro, J C Romeu, R Geraldes, J A Pereira da Silva
Systemic lupus erythematosus (SLE) may involve the nervous system but there are no specific biomarkers of neuroSLE. Limbic encephalitis has been rarely associated with SLE. We present a case of a 22-year-old black woman where typical SLE psychosis evolved to an encephalopathy with atypical features, normal MRI, electroencephalogram slowing and frontal and occipito-temporal hypometabolism on fluorodeoxyglucose positron emission tomography (FDG PET).Memory deficits, bizarre behaviour, psychosis, neuromyotonia and movement disorders have been described in autoimmune central nervous system disorders and associated with specific antibodies...
July 17, 2016: Lupus
https://www.readbyqxmd.com/read/27416844/wernicke-s-encephalopathy-mimicking-neuropsychiatric-symptoms-in-patients-with-systemic-lupus-erythematosus-a-report-of-three-cases-and-literature-review
#14
S Appenzeller, F Reis, L T Lavras Costallat, J Adams Pérez, C F Saldanha, O A Monticielo
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease that involves many organs and systems. Nervous system involvement in SLE encompasses neurological and psychiatric disorders, and remains a diagnostic and therapeutic challenge. Wernicke's encephalopathy (WE) is a neurological disorder that occurs as a consequence of thiamine deficiency, and its clinical presentation resembles the neuropsychiatric events attributed to SLE (NPSLE). Differentiation between these two entities is crucial because their treatment differs greatly and can change prognosis...
July 14, 2016: Lupus
https://www.readbyqxmd.com/read/27365370/incidence-of-systemic-lupus-erythematosus-in-a-population-based-cohort-using-revised-1997-american-college-of-rheumatology-and-the-2012-systemic-lupus-international-collaborating-clinics-classification-criteria
#15
P Ungprasert, V Sagar, C S Crowson, S Amin, A Makol, F C Ernste, T G Osborn, K G Moder, T B Niewold, H Maradit-Kremers, R Ramsey-Goldman, V R Chowdhary
In 2012, the Systemic Lupus International Collaborating Clinics (SLICC) group published a new set of classification criteria for systemic lupus erythematosus (SLE). Studies applying these criteria to real-life scenarios have found either equal or greater sensitivity and equal or lower specificity to the 1997 ACR classification criteria (ACR 97). Nonetheless, there are no studies that have used the SLICC 12 criteria to investigate the incidence of lupus. We used the resource of the Rochester Epidemiology Project to identify incident SLE patients in Olmsted County, Minnesota, from 1993 to 2005, who fulfilled the ACR 97 or SLICC 12 criteria...
June 30, 2016: Lupus
https://www.readbyqxmd.com/read/27267643/myelopathy-in-systemic-lupus-erythematosus-clinical-laboratory-radiological-and-progression-findings-in-a-cohort-of-1-193-patients
#16
Beatriz Lavras Costallat, Daniel Miranda Ferreira, Lilian Tereza Lavras Costallat, Simone Appenzeller
OBJECTIVE: To describe clinical, laboratory, radiological and progression characteristics of myelopathy in systemic lupus erythematosus (SLE). PATIENTS AND METHODS: A retrospective analysis was performed on a cohort of 1193 patients with SLE (ACR criteria) in order to identify patients with myelopathy (neuropsychiatric ACR). Disease activity was assessed by the SLE activity index (SLEDAI) on the date of the event and functional capacity was assessed by the Expanded Disability Status Scale (EDSS) at the last visit...
May 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27225212/hughes-syndrome-and-epilepsy-when-to-test-for-antiphospholipid-antibodies
#17
M H A Noureldine, G Harifi, A Berjawi, A A Haydar, M Nader, R Elnawar, A Sweid, J Al Saleh, M A Khamashta, I Uthman
Epilepsy and seizures are reported among the neurological manifestations of antiphospholipid syndrome (APS) at a prevalence rate of approximately 8%, which is nearly 10 times the prevalence of epilepsy in the general population. The association of seizures with antiphospholipid antibodies (aPL) is even more significant in the presence of systemic lupus erythematosus (SLE). In this review, we discuss the epidemiological, pathophysiological, laboratory, clinical, and radiological aspects of this association, and derive suggestions on when to consider testing for aPL in epileptic patients and how to manage seizures secondary to APS based on literature data...
May 25, 2016: Lupus
https://www.readbyqxmd.com/read/27216418/a-study-of-the-influence-of-ethnicity-on-serology-and-clinical-features-in-lupus
#18
S A Morais, D A Isenberg
OBJECTIVE: The objective of this study was to review the links between ethnicity, serology and clinical expression in systemic lupus erythematosus (SLE) in a single cohort that was followed over a 36-year period. PATIENTS AND METHODS: Patients with SLE treated at the University College London Hospitals (UCLHs) between January 1978 and December 2013 formed the cohort. We assessed the demographic, clinical and serological data. Standard methods were used for laboratory testing...
May 22, 2016: Lupus
https://www.readbyqxmd.com/read/27163251/abnormal-increase-of-neuronal-precursor-cells-and-exacerbated-neuroinflammation-in-the-corpus-callosum-in-murine-model-of-systemic-lupus-erythematosus
#19
Joseph Wai-Hin Leung, Benson Wui-Man Lau, Vera Sau-Fong Chan, Chak-Sing Lau, Kwok-Fai So
PURPOSE: Systemic Lupus Erythematosus (SLE) is an autoimmune disease which is characterised by elevated levels of autoantibodies and cytokines in the body. Via alteration of the regulation of inflammation, damage to different organ systems, including the central nervous system (CNS), was found in SLE patients. Patients diagnosed with SLE were reported to suffer from different kinds of psychiatric signs and symptoms. As neurogenesis has been suggested to be a potential key player of psychiatric symptoms and emotional behavior disturbances, this study aims to investigate whether neurogenesis is altered in an animal model of SLE...
May 2, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/27149490/plasmapheresis-is-associated-with-better-renal-outcomes-in-lupus-nephritis-patients-with-thrombotic-microangiopathy-a-case-series-study
#20
Qiu-Yu Li, Feng Yu, Fu-De Zhou, Ming-Hui Zhao
The aim of this study was to evaluate the efficacy of plasmapheresis in patients with lupus nephritis-combined thrombotic microangiopathy (TMA) in a Chinese cohort.Clinical and therapeutic data of patients with lupus nephritis-combined TMA were collected retrospectively. A comparison between those with and without plasmapheresis was performed.Seventy patients with renal biopsy-proven TMA in lupus nephritis were treated with conventional combined corticosteroid and immunosuppressive agents as induction therapy, 9 of the 70 patients received additional plasmapheresis...
May 2016: Medicine (Baltimore)
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