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JOURNAL ARTICLE
Tarini Prasad Sahoo, Chirag Desai, Shyam Agarwal, Amit Rauthan, Boman Dhabhar, Ghanshyam Biswas, Sandeep Batra, Rajat Saha, Arun Philip, Vijay Agarwal, Palanki Satya Dattatreya, P N Mohapatra, Chetan Deshmukh, Sagar Bhagat, Saiprasad Patil, Hanmant Barkate
In advanced Renal Cell Carcinoma (aRCC), systemic therapy is the mainstay of treatment, with no or little role for surgery in these patients. Tyrosine kinase inhibitors (TKIs) and immune-oncological (IOs) therapies, either alone or in combination, are recommended in these patients depending on patient and tumour factors. The sequencing of therapies is critical in RCC because the choice of subsequent line therapy is heavily dependent on the response and duration of the previous treatment. There are additional barriers to RCC treatment in India...
August 9, 2023: BMC Cancer
#22
JOURNAL ARTICLE
Vijay Sandeep Kumar Madrolu, Shiva Ram Male, Rishi Bhardwaj, Baskar Theagarayan
BACKGROUND AND AIMS: Induced prismatic effects due to poor fitting spectacle frames is a common problem, seen in most of the spectacle wearers and this improper fitting is often due to optical center demarcation on lenses and this error causes asthenopic symptoms and diplopia. However, these errors are most common in developing countries due to lack of awareness, hence a standardized regulation is required. The current study aimed to estimate the amount of prismatic effect that is induced due to the decentration of an optical center in ophthalmic lens...
August 2023: Health Science Reports
#23
JOURNAL ARTICLE
Pallavi Jain, Vijay K Vishvakarma, Prashant Singh, Rajesh Kumar, Dinesh Kumar, Sulekh Chandra, Sandeep Yadav, Namita Misra
Mn(II) and Cu(II) complexes having the formula [M(L)2]X2 of ligand i.e., 2-acetyl-5-methylfuranthiosemicarbazone were synthesized. Various analytical and spectroscopic techniques described the structure of synthesized complexes. Molar conductance confirmed the electrolytic nature of the complexes. The theoretical study of the complexes explained the structural property and reactivity. The chemical reactivity, interaction and stability of the ligand and metal complexes were studied with the help of global reactivity descriptors...
July 10, 2023: Chemistry & Biodiversity
#24
EDITORIAL
Omprakash Singh, Shahul Ameen, Chittaranjan Andrade, Vijaya Chandra Reddy Avula, Debasish Basu, Samrat Singh Bhandari, Manjeet Singh Bhatia, Arabinda Brahma, Shyamanta Das, Koushik Sinha Deb, Avinash Desousa, Prosenjit Ghosh, Nishant Goyal, Sandeep Grover, Nitin Gupta, Vijay Harbishettar, Sujita K Kar, Vinay Kumar, Indu Pankajakshan Vijayanthi, Bhavesh Lakdawala, Satyakam Mahapatra, Varun Mehta, Vikas Menon, K K Mishra, Naresh Nebhinani, Samir K Praharaj, Jyoti Prakash, Sai Krishna Puli, N N Raju, T S S Rao, Laxmikanth Rathi, Y C Janardhan Reddy, Rajesh Sagar, Siddharth Sarkar, Sujit Sarkhel, M Aleem Siddiqui, Vipul Singh, Nilima D Shah, Parth Singh, Srinivasan Durairaj, Alka A Subramanyam, Jagadisha Thirthalli, Adarsh Tripathi, Mrugesh Vaishnav, Ganesan Venkatasubramanian
No abstract text is available yet for this article.
May 2023: Indian Journal of Psychiatry
#25
REVIEW
H K Chopra, G S Wander, C K Ponde, Navin C Nanda, Dinesh Khullar, K Venugopal, Saumitra Ray, Tiny Nair, D S Rana, Vijay Kher, J P S Sawhney, R R Kasliwa, A Jabir, Rabin Chakraborty, Praveen Chandra, Sandeep Bansal, Viveka Kumar, A K Pancholia, Aditya Kapoor, Sunil Prakash, Anil Saxena, Vishal Rastogi, Vinod Sharma, Y K Arora, Arup Dasbiswas, Mohan Bhargava, Aparna Jaswal, K Bhargava, Mona Bhatia, A K Omar, N N Khanna, Rajiv Passey, Dilip Bhalla, I B Vijayalakshmi, A K Bhalla, Asha Moorthy, H S Isser, S S Mishra, S N Routray, Vivek Tandon, Ajay Sinha, Manish Bansal, Praveen Jain, Ramesh Hotchandani, Dharmendra Jain, V K Katyal, Sanjiv Gulati, Rohit Tandon, Shalini Jaggi, Blessy Sehgal, Vitull Gupta, Rahul Mehrotra, N C Krishnamani, S N Pathak, M S Yadav, Rajeev Chawla, Jyotirmoy Pal, Nandini Chatterjee, Shambo S Samajdar, N R Shastry
;Heart failure (HF) is a huge global public health task due to morbidity, mortality, disturbed quality of life, and major economic burden. It is an area of active research and newer treatment strategies are evolving. Recently angiotensin receptor-neprilysin inhibitor (ARNI), a class of drugs (the first agent in this class, Sacubitril-Valsartan), reduces cardiovascular mortality and morbidity in chronic HF patients with reduced left ventricular ejection fraction (LVEF). Positive therapeutic effects have led to a decrease in cardiovascular mortality and HF hospitalizations (HFH), with a favorable safety profile, and have been documented in several clinical studies with an unquestionable survival benefit with ARNI, Sacubitril-Valsartan...
February 2023: Journal of the Association of Physicians of India
#26
JOURNAL ARTICLE
Anil Arora, Ashish Kumar, Anil C Anand, Ajay Kumar, Ajay Yadav, Ajit Bhagwat, Ajit S Mullasari, Ambarish Satwik, Anoop Saraya, Ashwani Mehta, Debabrata Roy, Duvvur Nageshwar Reddy, Govind Makharia, Jagarapudi M K Murthy, Jayanta Roy, Jitendra P S Sawhney, Kameshwar Prasad, Mahesh Goenka, Mathew Philip, Meenakshisundaram Umaiorubahan, Nakul Sinha, Padinhare P Mohanan, Padmavathy N Sylaja, Pinjala Ramakrishna, Prafulla Kerkar, Praveer Rai, Rakesh Kochhar, Rakesh Yadav, Sandeep Nijhawan, Saroj K Sinha, Shirish M Hastak, Sidharth Viswanathan, Uday C Ghoshal, Unnikrishnan Madathipat, Vijay Thakore, Vinay Dhir, Vivek A Saraswat, Zaheer Nabi
Antiplatelet and/or anticoagulant agents (collectively known as antithrombotic agents) are used to reduce the risk of thromboembolic events in patients with conditions such as atrial fibrillation, acute coronary syndrome, recurrent stroke prevention, deep vein thrombosis, hypercoagulable states and endoprostheses. Antithrombotic-associated gastrointestinal (GI) bleeding is an increasing burden due to the growing population of advanced age with multiple comorbidities and the expanding indications for the use of antiplatelet agents and anticoagulants...
June 5, 2023: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
#27
JOURNAL ARTICLE
Kaushik Satyaprakash, Wiqar Ahmed Khan, Sandeep Prabhakarrao Chaudhari, Shilpshri Vasant Shinde, Sunil Waman Kolte, Nilesh Ramchandra Pansare, Amrut Vijay Likhite
BACKGROUND: Porcine cysticercosis, caused by metacestodes of Taenia solium is an important neglected zoonosis. We evaluated the presence of anti-cysticercal antibodies and T. solium specific DNA in pig sera and blood samples respectively collected from Maharashtra, India. METHODS: A total of three antigens (Scolex Antigen (SA), Membrane Body Antigen (MBA) and Excretory-Secretory Antigen (ESA)) were prepared from metacestodes of T. solium and employed in an in-house developed indirect-IgG ELISA for serological screening of 1000 porcine sera samples at Department of Veterinary Public Health, Nagpur Veterinary College, Maharashtra, India...
2023: Iranian Journal of Parasitology
#28
JOURNAL ARTICLE
Smeeta Gajendra, Shilpa Anupurba, Ritu Gupta, Saumyaranjan Mallick, Devasis Panda, Deepshi Thakral, Sanjeev Kumar Gupta, Sameer Bakhshi, Rachna Seth, Sandeep Rai, Vijay K Prajapati, Saroj Singh
INTRODUCTION: Acute myeloid leukemia (AML) with RAM immunophenotype is a distinct subtype of AML, as described by the Children's Oncology Group (COG), with characteristic morphological and immunophenotypic properties. It is characterized by strong CD56 expression with dim to negative CD45, HLA-DR, and CD38 expression. It is an aggressive leukemia with a poor response to induction chemotherapy and/or frequent relapses. METHODS: Seven cases with the characteristic RAM immunophenotype were identified in this retrospective analysis of newly diagnosed pediatric AML cases from January 2019 to December 2021...
August 2023: International Journal of Laboratory Hematology
#29
JOURNAL ARTICLE
Marc R Yago, Khamir Mehta, Maitreyee Bose, Sharvari Bhagwat, Vivek S Chopra, Sandeep Dutta, Vijay V Upreti
BACKGROUND: Carfilzomib is an irreversible second-generation proteasome inhibitor that has a short elimination half-life but much longer pharmacodynamic (PD) effect based on its irreversible mechanism of action, making it amenable to longer dosing intervals. A mechanistic pharmacokinetic/pharmacodynamic (PK/PD) model was built using a bottom-up approach, based on the mechanism of action of carfilzomib and the biology of the proteasome, to provide further evidence of the comparability of once-weekly and twice-weekly dosing...
April 18, 2023: Clinical Pharmacokinetics
#30
REVIEW
Mrinalini Roy, Shreya Chakraborty, Sandeep Kumar Srivastava, Sanket Kaushik, Anupam Jyoti, Vijay Kumar Srivastava
Entamoeba histolytica (Eh), a microaerophilic parasite, causes deadly enteric infections that result in Amoebiasis. Every year, the count of invasive infections reaches 50 million approximately and 40,000 to 1,00,000 deaths occurring due to amoebiasis are reported globally. Profound inflammation is the hallmark of severe amoebiasis which is facilitated by immune first defenders, neutrophils. Due to size incompatibility, neutrophils are unable to phagocytose Eh and thus, came up with the miraculous antiparasitic mechanism of neutrophil extracellular traps (NETs)...
April 1, 2023: International Immunopharmacology
#31
JOURNAL ARTICLE
Jacob DeBerry, Parth Rali, Michael McDaniel, Christopher Kabrhel, Rachel Rosovsky, Roman Melamed, Oren Friedman, Jean M Elwing, Vijay Balasubramanian, Sandeep Sahay, Eduardo Bossone, Mary Jo S Farmer, Andrew J P Klein, Megan E Hamm, Charles B Ross, Belinda N Rivera-Lebron
BACKGROUND: Interhospital transfer (IHT) of patients with acute life-threatening pulmonary embolism (PE) is necessary to facilitate specialized care and access to advanced therapies. Our goal was to understand what barriers and facilitators may exist during this transfer process from the perspective of both receiving and referring physicians. METHODS: This qualitative descriptive study explored physician experience taking care of patients with life threatening PE...
2023: Frontiers in Medicine
#32
JOURNAL ARTICLE
Pragya, Krishna Kant Sharma, Sandeep Kumar, Manisha, Davender Singh, Vijay Kumar, Bijender Singh
Microbial phytases are potentially excellent candidates for eliminating anti-nutrient i.e. phytic acid, due to hydrolysis of phospho-monoester linkages present in the phytic acid. An average 2.29-fold increase in phytase production was obtained after statistical optimization in solid-state fermentation. Aspergillus oryzae SBS50 phytase was immobilized on a Ca-alginate matrix with an effectiveness of 53%. Immobilized-phytase retained > 50% activity after recycling for five cycles and also displayed more stability in the presence of organic solvents, metal ions, and detergents as compared to free enzyme...
December 26, 2022: Letters in Applied Microbiology
#33
JOURNAL ARTICLE
Aman Kumar, Kashmiri Lal, Vijay Kumar, Mohd Murtaza, Sundeep Jaglan, Avijit Kumar Paul, Sandeep Yadav, Kamlesh Kumari
In present era, heterocyclic compounds containing two or three nitrogen atoms play a vital role in drug discovery. In this context, a new class of isatin-semicarbazone tethered 1,2,3-triazole hybrids was synthesized via Cu(I)-mediated azide alkyne cycloaddition reaction. Structural characteristics of the newly derived compounds were identified by various spectral techniques like FTIR, 1 H NMR, 13 C NMR, HRMS and single crystal X-ray crystallography. Synthesized derivatives were also screened for in vitro antimicrobial and antibiofilm activity against different microbial species...
January 21, 2023: Bioorganic Chemistry
#34
JOURNAL ARTICLE
Malidi Ahamadi, Johannes Kast, Po-Wei Chen, Xiaojun Huang, Sandeep Dutta, Vijay V Upreti
Talimogene Laherparepvec (T-VEC) is a first in class oncolytic virotherapy approved for the treatment of unresectable melanoma recurrent after initial surgery. Biodistribution data from phase 2 study was used to develop a viral kinetics mechanistic model describing the interaction between cytokines like granulocyte-macrophage colony-stimulating factor (GM-CSF), immune system and T-VEC treatment. Our analysis found 1) viral infection rate has great influence on T-VEC treatment efficacy, 2) an increase of T-VEC dose of 102 pfu/mL 21 days and beyond after the initial dose of T-VEC resulted in a ~12% increase in response; and 3) at the systemic level the ratio of resting innate immune cells to the death rate of innate immune impact T-VEC treatment efficacy...
December 23, 2022: CPT: Pharmacometrics & Systems Pharmacology
#35
JOURNAL ARTICLE
Deepshi Thakral, Vivek Kumar Singh, Ritu Gupta, Nitu Jha, Aafreen Khan, Gurvinder Kaur, Sandeep Rai, Vijay Kumar, Manisha Supriya, Sameer Bakhshi, Rachna Seth
To gain insights into the idiosyncrasies of CD34 + enriched leukemic stem cells, we investigated the nature and extent of transcriptional heterogeneity by single-cell sequencing in pediatric AML. Whole transcriptome analysis of 28,029 AML single cells was performed using the nanowell cartridge-based barcoding technology. Integrated transcriptional analysis identified unique leukemic stem cell clusters of each patient and intra-patient heterogeneity was revealed by multiple LSC-enriched clusters differing in their cell cycle processes and BCL2 expression...
December 17, 2022: Annals of Hematology
#36
JOURNAL ARTICLE
Christine Y Zhou, Sandeep Sahay, Oksana Shlobin, Francisco J Soto, Stephen C Mathai, Lana Melendres-Groves, Christopher J Mullin, Deborah J Levine, Dana Kay, Kristin Highland, Eduardo Bossone, Abby Poms, Humna Memon, Vijay Balasubramanian, Mary Jo S Farmer, Franck Rahaghi, Jean M Elwing
The coronavirus of 2019 (COVID-19) disrupted delivery of healthcare. Patients with pulmonary hypertension (PH), especially pulmonary arterial hypertension (PAH), require significant resources for both diagnosis and management and are at high risk for decompensation due to disruption in their care. A survey consisting of 47 questions related to the care of patients with PH was designed by the American College of Chest Physicians 2020-2021 Pulmonary Vascular Disease (PVD) NetWork Steering Committee and sent to all members of the PVD NetWork, as well as the multiple other professional networks for PH...
November 26, 2022: Respiratory Medicine
#37
REVIEW
Madhuree Kumari, Kamal A Qureshi, Mariusz Jaremko, James White, Sandeep Kumar Singh, Vijay Kumar Sharma, Kshitij Kumar Singh, Gustavo Santoyo, Gerardo Puopolo, Ajay Kumar
As endophytes are widely distributed in the plant's internal compartments and despite having enormous potential as a biocontrol agent against postharvest diseases of fruits, the fruit-endophyte-pathogen interactions have not been studied detail. Therefore, this review aims to briefly discuss the colonization patterns of endophytes and pathogens in the host tissue, the diversity and distribution patterns of endophytes in the carposphere of fruits, and host-endophyte-pathogen interactions and the molecular mechanism of the endophytic microbiome in postharvest disease management in fruits...
2022: Frontiers in Plant Science
#38
REVIEW
Jaison Joseph, Abin Varghese, V R Vijay, Manju Dhandapani, Sandeep Grover, Suresh K Sharma, Meenu Singh, Sucheta Mann, Biji P Varkey
BACKGROUND: Problematic internet use (PIU) among school going adolescents constitutes a major area of concern. However, no comprehensive reports are available to determine the magnitude of the problem. This study aimed to estimate the pooled prevalence of PIU among school going adolescents in India. METHODS: We conducted a systematic review and meta analysis of 15 studies conducted in various parts of India. RESULTS: The prevalence of moderate and severe PIU among Indian school going adolescents was 21...
2022: Indian Journal of Community Medicine
#39
JOURNAL ARTICLE
Sandeep Rai, Nupur Das, Ritu Gupta, Lalit Kumar, Atul Sharma, Saroj Singh, Vijay K Prajapati
INTRODUCTION: CD229 has been found to be a useful plasma cell (PC) gating marker in multiple myeloma (MM). This study analyses the expression profile of CD229 on various bone marrow compartments namely, PC, non-PC and hematogones (HGs) using Multiparameter flow cytometry (MFC). Furthermore, it evaluates the ability of CD229 to delineate normal PC (NPC) from aberrant PC (APC) in measurable residual disease assessment (MRD) in MM. METHODS: Bone marrow aspirates from patients diagnosed with MM (per standard IMWG criteria) were collected in EDTA and processed for MFC using a single tube 14-color antibody panel as per standard operating procedure...
April 2023: International Journal of Laboratory Hematology
#40
JOURNAL ARTICLE
S K Katiyar, S N Gaur, R N Solanki, Nikhil Sarangdhar, J C Suri, Raj Kumar, G C Khilnani, Dhruva Chaudhary, Rupak Singla, Parvaiz A Koul, Ashok A Mahashur, A G Ghoshal, D Behera, D J Christopher, Deepak Talwar, Dhiman Ganguly, H Paramesh, K B Gupta, Mohan Kumar T, P D Motiani, P S Shankar, Rajesh Chawla, Randeep Guleria, S K Jindal, S K Luhadia, V K Arora, V K Vijayan, Abhishek Faye, Aditya Jindal, Amit K Murar, Anand Jaiswal, Arunachalam M, A K Janmeja, Brijesh Prajapat, C Ravindran, Debajyoti Bhattacharyya, George D'Souza, Inderpaul Singh Sehgal, J K Samaria, Jogesh Sarma, Lalit Singh, M K Sen, Mahendra K Bainara, Mansi Gupta, Nilkanth T Awad, Narayan Mishra, Naveed N Shah, Neetu Jain, Prasanta R Mohapatra, Parul Mrigpuri, Pawan Tiwari, R Narasimhan, R Vijai Kumar, Rajendra Prasad, Rajesh Swarnakar, Rakesh K Chawla, Rohit Kumar, S Chakrabarti, Sandeep Katiyar, Saurabh Mittal, Sonam Spalgais, Subhadeep Saha, Surya Kant, V K Singh, Vijay Hadda, Vikas Kumar, Virendra Singh, Vishal Chopra, Visweswaran B
Inhalational therapy, today, happens to be the mainstay of treatment in obstructive airway diseases (OADs), such as asthma, chronic obstructive pulmonary disease (COPD), and is also in the present, used in a variety of other pulmonary and even non-pulmonary disorders. Hand-held inhalation devices may often be difficult to use, particularly for children, elderly, debilitated or distressed patients. Nebulization therapy emerges as a good option in these cases besides being useful in the home care, emergency room and critical care settings...
2022: Indian Journal of Tuberculosis
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