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David c miller

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https://www.readbyqxmd.com/read/28935232/utilising-physiological-principles-of-motor-unit-recruitment-to-reduce-fatigability-of-electrically-evoked-contractions-a-narrative-review
#1
Trevor S Barss, Emily N Ainsley, Francisca C Claveria-Gonzalez, M John Luu, Dylan J Miller, Matheus J Wiest, David F Collins
Neuromuscular electrical stimulation (NMES) is used to produce contractions to restore movement and reduce secondary complications for individuals experiencing motor impairment. NMES is conventionally delivered through a single pair of electrodes over a muscle belly or nerve trunk using short pulse durations and frequencies between 20-40 Hz (conventional NMES). Unfortunately, the benefits and widespread use of conventional NMES are limited by contraction fatigability, which is due in large part to the non-physiological way that contractions are generated...
September 18, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28924191/metabolic-crosstalk-regulates-porphyromonas-gingivalis-colonization-and-virulence-during-oral-polymicrobial-infection
#2
Masae Kuboniwa, John R Houser, Erik L Hendrickson, Qian Wang, Samar A Alghamdi, Akito Sakanaka, Daniel P Miller, Justin A Hutcherson, Tiansong Wang, David A C Beck, Marvin Whiteley, Atsuo Amano, Huizhi Wang, Edward M Marcotte, Murray Hackett, Richard J Lamont
Many human infections are polymicrobial in origin, and interactions among community inhabitants shape colonization patterns and pathogenic potential (1) . Periodontitis, which is the sixth most prevalent infectious disease worldwide (2) , ensues from the action of dysbiotic polymicrobial communities (3) . The keystone pathogen Porphyromonas gingivalis and the accessory pathogen Streptococcus gordonii interact to form communities in vitro and exhibit increased fitness in vivo (3,4) . The mechanistic basis of this polymicrobial synergy, however, has not been fully elucidated...
September 18, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28918054/rapid-and-sensitive-detection-of-breast-cancer-cells-in-patient-blood-with-nuclease-activated-probe-technology
#3
Sven Kruspe, David D Dickey, Kevin T Urak, Giselle N Blanco, Matthew J Miller, Karen C Clark, Elliot Burghardt, Wade R Gutierrez, Sneha D Phadke, Sukriti Kamboj, Timothy Ginader, Brian J Smith, Sarah K Grimm, James Schappet, Howard Ozer, Alexandra Thomas, James O McNamara, Carlos H Chan, Paloma H Giangrande
A challenge for circulating tumor cell (CTC)-based diagnostics is the development of simple and inexpensive methods that reliably detect the diverse cells that make up CTCs. CTC-derived nucleases are one category of proteins that could be exploited to meet this challenge. Advantages of nucleases as CTC biomarkers include: (1) their elevated expression in many cancer cells, including cells implicated in metastasis that have undergone epithelial-to-mesenchymal transition; and (2) their enzymatic activity, which can be exploited for signal amplification in detection methods...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28893869/the-muc5b-promoter-polymorphism-is-associated-with-specific-interstitial-lung-abnormality-subtypes
#4
Rachel K Putman, Gunnar Gudmundsson, Tetsuro Araki, Mizuki Nishino, Sigurdur Sigurdsson, Elías F Gudmundsson, Gudny Eiríksdottír, Thor Aspelund, James C Ross, Raúl San José Estépar, Ezra R Miller, Yoshitake Yamada, Masahiro Yanagawa, Noriyuki Tomiyama, Lenore J Launer, Tamara B Harris, Souheil El-Chemaly, Benjamin A Raby, Michael H Cho, Ivan O Rosas, George R Washko, David A Schwartz, Edwin K Silverman, Vilmundur Gudnason, Hiroto Hatabu, Gary M Hunninghake
The MUC5B promoter polymorphism (rs35705950) has been associated with interstitial lung abnormalities (ILA) in white participants from the general population; whether these findings are replicated and influenced by the ILA subtype is not known. We evaluated the associations between the MUC5B genotype and ILA in cohorts with extensive imaging characterisation.We performed ILA phenotyping and MUC5B promoter genotyping in 5308 and 9292 participants from the AGES-Reykjavik and COPDGene cohorts, respectively.We found that ILA was present in 7% of participants from the AGES-Reykjavik, 8% of non-Hispanic white participants from COPDGene and 7% of African-American participants from COPDGene...
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28888030/increased-sign-tracking-behavior-in-adolescent-rats
#5
Nicole E DeAngeli, Sarah B Miller, Heidi C Meyer, David J Bucci
An autoshaping procedure was used to test the notion that conditioned stimuli (CSs) gain greater incentive salience during adolescence than young adulthood under conditions of social isolation rearing and food restriction. Rats were single-housed and placed on food restriction during 10 daily training sessions in which a lever (CS(+) ) was presented then followed immediately by a food unconditioned stimulus (US). A second lever (CS(-) ) was presented on intermixed trials and was not reinforced. Despite the fact that food delivery was not contingent on the rats' behavior, all rats exhibited behaviors directed towards the lever (i...
September 9, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28885925/military-global-health-engagement-and-low-dose-ionizing-radiation
#6
Alexandra C Miller, John Gilstad, David J Brenner
No abstract text is available yet for this article.
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28882485/zinc-chloride-rapidly-stimulates-efflux-transporters-in-renal-proximal-tubules-of-killifish-fundulus-heteroclitus
#7
Alexander Zaremba, David S Miller, Gert Fricker
Multidrug resistance-related protein 2 (Mrp2) is an ATP-driven efflux pump at the luminal membrane in renal proximal tubules. It acts as detoxification mechanism by transporting xenobiotics and metabolic products into urine. The trace element zinc is essential for cellular growth, differentiation and survival. It modulates immune response and is used as dietary supplement. Here, we found that 0.1-10μM ZnCl2 rapidly stimulated transport of the Mrp2 probe substrate Texas Red (TR) in isolated killifish renal proximal tubules, which provide an established model system to measure efflux transporter activity by using fluorescent probe substrates, confocal microscopy and image analysis...
September 4, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28881905/perforated-esophageal-intervention-focus-perf-study-a-multi-center-examination-of-contemporary-treatment
#8
J T Ali, R D Rice, E A David, J D Spicer, J J Dubose, L Bonavina, S Siboni, T A O'Callaghan, X Luo-Owen, S Harrison, C G Ball, J Bini, G A Vercruysse, D Skarupa, C C Miller Iii, A L Estrera, K G Khalil
The treatment of esophageal perforation (EP) remains a significant clinical challenge. While a number of investigators have previously documented efficient approaches, these were mostly single-center experiences reported prior to the introduction of newer technologies: specifically endoluminal stents. This study was designed to document contemporary practice in the diagnosis and management of EP at multiple institutions around the world and includes early clinical outcomes. A five-year (2009-2013) multicenter retrospective review of management and outcomes for patients with thoracic or abdominal esophageal perforation was conducted...
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28877031/genetic-associations-with-gestational-duration-and-spontaneous-preterm-birth
#9
Ge Zhang, Bjarke Feenstra, Jonas Bacelis, Xueping Liu, Lisa M Muglia, Julius Juodakis, Daniel E Miller, Nadia Litterman, Pan-Pan Jiang, Laura Russell, David A Hinds, Youna Hu, Matthew T Weirauch, Xiaoting Chen, Arun R Chavan, Günter P Wagner, Mihaela Pavličev, Mauris C Nnamani, Jamie Maziarz, Minna K Karjalainen, Mika Rämet, Verena Sengpiel, Frank Geller, Heather A Boyd, Aarno Palotie, Allison Momany, Bruce Bedell, Kelli K Ryckman, Johanna M Huusko, Carmy R Forney, Leah C Kottyan, Mikko Hallman, Kari Teramo, Ellen A Nohr, George Davey Smith, Mads Melbye, Bo Jacobsson, Louis J Muglia
BACKGROUND: Despite evidence that genetic factors contribute to the duration of gestation and the risk of preterm birth, robust associations with genetic variants have not been identified. We used large data sets that included the gestational duration to determine possible genetic associations. METHODS: We performed a genomewide association study in a discovery set of samples obtained from 43,568 women of European ancestry using gestational duration as a continuous trait and term or preterm (<37 weeks) birth as a dichotomous outcome...
September 21, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28866451/sexual-and-reproductive-health-care-utilization-and-preferences-reported-by-young-women-with-cystic-fibrosis
#10
Traci M Kazmerski, Gregory S Sawicki, Elizabeth Miller, Kelley A Jones, Kaleab Z Abebe, Lisa K Tuchman, Sigrid Ladores, Ronald C Rubenstein, Scott D Sagel, Daniel J Weiner, Joseph M Pilewski, David M Orenstein, Sonya Borrero
BACKGROUND: This study aimed to describe and compare the sexual and reproductive health (SRH) care utilization among young women with cystic fibrosis (CF) with the general United States (U.S.) population. METHODS: Women with CF ages 15-24years from five geographically diverse U.S. CF centers participated in a survey investigating SRH. Results were summarized and compared to a nationally representative sample of young women aged 15-24 who participated in the U.S...
August 30, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28864444/hypoplastic-left-heart-syndrome-with-intact-or-restrictive-atrial-septum-a-report-from-the-international-fetal-cardiac-intervention-registry
#11
David W Jantzen, Anita J Moon-Grady, Shaine A Morris, Aimee K Armstrong, Christoph Berg, Joanna H Dangel, Carlen G Fifer, Michele Frommelt, Ulrich Gembruch, Ulrike Herberg, Edgar T Jaeggi, Eftichia V Kontopoulos, Audrey C Marshall, Owen Miller, Renate Oberhoffer, Dick Oepkes, Carlos A Pedra, Simone R Pedra, Fabio Peralta, Ruben A Quintero, Greg Ryan, Sarah K Gelehrter
Infants with hypoplastic left heart syndrome and an intact or highly restrictive atrial septum (HLHS-IAS) represent a high risk subset. Fetal cardiac intervention (FCI) for fetuses with HLHS-IAS has been reported in single-institution series as a therapy that may improve outcomes. This study utilizes the International Fetal Cardiac Intervention Registry (IFCIR) to examine fetal and maternal characteristics and pregnancy and neonatal outcome data for FCI in this population.
September 1, 2017: Circulation
https://www.readbyqxmd.com/read/28844913/analysis-of-predictors-and-probability-of-aneurysm-occlusion-in-the-ica-after-treatment-with-pipeline-embolization-device
#12
Leonardo B C Brasiliense, Pedro Aguilar-Salinas, David A Miller, Rabih G Tawk, Eric A Sauvageau, Ricardo A Hanel
BACKGROUND: Although the PED has proven to be an excellent option for ICA aneurysms, the rate of occlusion remains difficult to predict and factors associated with aneurysm occlusion are not well elucidated. This study aimed to investigate predictors and the rate of occlusion for aneurysms along the ICA. METHODS: 117 saccular ICA aneurysms treated with the PED were studied. Occlusion rates were divided among 4 groups. Group A [lesions > 10 mm in the proximal ICA (petrous to the superior hypophyseal segments)]...
August 24, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28842414/the-atypical-map-kinase-swip-13-erk8-regulates-dopamine-transporters-through-a-rho-dependent-mechanism
#13
Daniel P Bermingham, J Andrew Hardaway, Osama Refai, Christian R Marks, Sam L Snider, Sarah M Sturgeon, William C Spencer, Roger J Colbran, David M Miller, Randy D Blakely
The neurotransmitter dopamine (DA) regulates multiple behaviors across phylogeny, with disrupted DA signaling in humans associated with addiction, attention-deficit/hyperactivity disorder (ADHD), schizophrenia, and Parkinson's disease. The DA transporter (DAT) imposes spatial and temporal limits on DA action, and provides for presynaptic DA recycling to replenish neurotransmitter pools. Molecular mechanisms that regulate DAT expression, trafficking and function, particularly in vivo, remain poorly understood, though recent studies have implicated Rho-linked pathways in psychostimulant action...
August 21, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28839941/factors-associated-with-high-cardiovascular-risk-in-a-primarily-african-american-urban-hiv-infected-population
#14
Shashwatee Bagchi, Shana Ab Burrowes, Lori E Fantry, Mian B Hossain, Gemechis H Tollera, Shyamasundaran Kottilil, C David Pauza, Michael Miller, Mona Baumgarten, Robert R Redfield
OBJECTIVE: To determine factors associated with increased risk of developing cardiovascular disease in a high-risk patient population. DESIGN: Cross-sectional analysis of a retrospective cohort study. METHODS: One-hundred patients at an inner city HIV clinic in 2008 were reviewed. The atherosclerotic vascular disease risk score was calculated using the Pooled Cohort Equation. Chi-square test was performed to identify associations of potential risk factors with elevated atherosclerotic vascular disease risk...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28833972/range-position-and-climate-sensitivity-the-structure-of-among-population-demographic-responses-to-climatic-variation
#15
Staci M Amburgey, David A W Miller, Evan H Campbell Grant, Tracy A G Rittenhouse, Michael F Benard, Jonathan L Richardson, Mark C Urban, Ward Hughson, Adrianne B Brand, Christopher J Davis, Carmen R Hardin, Peter W C Paton, Christopher J Raithel, Rick A Relyea, A Floyd Scott, David K Skelly, Dennis E Skidds, Charles K Smith, Earl E Werner
Species' distributions will respond to climate change based on the relationship between local demographic processes and climate and how this relationship varies based on range position. A rarely tested demographic prediction is that populations at the extremes of a species' climate envelope (e.g., populations in areas with the highest mean annual temperature) will be most sensitive to local shifts in climate (i.e., warming). We tested this prediction using a dynamic species distribution model linking demographic rates to variation in temperature and precipitation for wood frogs (Lithobates sylvaticus) in North America...
August 19, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28832865/drivers-of-payment-variation-in-90-day-coronary-artery-bypass-grafting-episodes
#16
Vinay Guduguntla, John D Syrjamaki, Chad Ellimoottil, David C Miller, Richard L Prager, Edward C Norton, Patricia Theurer, Donald S Likosky, James M Dupree
Importance: Coronary artery bypass grafting (CABG) is scheduled to become a mandatory Medicare bundled payment program in January 2018. A contemporary understanding of 90-day CABG episode payments and their drivers is necessary to inform health policy, hospital strategy, and clinical quality improvement activities. Furthermore, insight into current CABG payments and their variation is important for understanding the potential effects of bundled payment models in cardiac care. Objective: To examine CABG payment variation and its drivers...
August 23, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28830766/functional-magnetic-resonance-imaging-of-auditory-cortical-fields-in-awake-marmosets
#17
Camille R Toarmino, Cecil C C Yen, Daniel Papoti, Nicholas A Bock, David A Leopold, Cory T Miller, Afonso C Silva
The primate auditory cortex is organized into a network of anatomically and functionally distinct processing fields. Because of its tonotopic properties, the auditory core has been the main target of neurophysiological studies ranging from sensory encoding to perceptual decision-making. By comparison, the auditory belt has been less extensively studied, in part due to the fact that neurons in the belt areas prefer more complex stimuli and integrate over a wider frequency range than neurons in the core, which prefer pure tones of a single frequency...
August 19, 2017: NeuroImage
https://www.readbyqxmd.com/read/28829599/nonpyrogenic-molecular-adjuvants-based-on-norabu-muramyldipeptide-and-norabu-glucosaminyl-muramyldipeptide-synthesis-molecular-mechanisms-of-action-biological-activities-in-vitro-and-in-vivo
#18
Roman Effenberg, Pavlína Turánek Knötigová, Daniel Zyka, Hana Čelechovská, Josef Mašek, Eliška Bartheldyová, Frantisek Hubatka, Štěpán Koudelka, Róbert Lukáč, Anna Kovalová, David Saman, Michal Křupka, Lucia Barkocziová, Petr Kosztyu, Marek Šebela, Ladislav Drož, Michal Hučko, Mária Kanásová, Andrew David Miller, Milan Raška, Miroslav Ledvina, Jaroslav Turanek
Apyrogenic fatty acyl analogues of muramyldipeptide (MDP) (abbreviated N-L18norAbuGMDP, N-B30norAbuGMDP, norAbuMDP-Lys(L18), norAbuMDP-Lys(B30), norAbuGMDP-Lys(L18), norAbuGMDP-Lys(B30), (B30)norAbuMDP, (L18)norAbuMDP) were designed and synthesized comprising the normuramyl-L-α-aminobutanoyl (norAbu) structural moiety. All new analogues show depressed pyrogenicity both as free compounds and in liposomal formulations when tested in vivo in rabbits (s.c. and i.v. application). The potency of analogues in selective activation of NOD2 and NLRP3 (inflammasome) receptors in vitro, but not NOD1, is demonstrated using transgenic cell-based detection systems...
August 22, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28819930/association-between-patient-satisfaction-and-short-term-outcomes-after-major-cancer-surgery
#19
Deborah R Kaye, Caroline R Richardson, Zaojun Ye, Lindsey A Herrel, Chad Ellimoottil, David C Miller
OBJECTIVE: The aim of this study was to investigate whether patient satisfaction, as measured by the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey, is associated with short-term outcomes after major cancer surgery. MATERIALS AND METHODS: We first used national Medicare claims to identify patients who underwent a major extirpative cancer surgery from 2011 to 2013. Next, we used Hospital Compare data to assign the HCAHPS score to the hospital where the patient underwent surgery...
August 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28818814/exposure-to-polybrominated-diphenyl-ethers-and-perfluoroalkyl-substances-in-a-remote-population-of-alaska-natives
#20
Samuel Byrne, Samarys Seguinot-Medina, Pamela Miller, Vi Waghiyi, Frank A von Hippel, C Loren Buck, David O Carpenter
BACKGROUND: Many Alaska Native communities rely on a traditional marine diet that contains persistent organic pollutants (POPs). The indoor environment is also a source of POPs. Polybrominated diphenyl ethers (PBDEs) and perfluoroalkyl substances (PFASs) are present both in the traditional diet and the home indoor environment. OBJECTIVES: We assessed exposure to PBDEs and PFASs among residents of two remote Alaska Native villages on St. Lawrence Island. Ninespine stickleback (Pungitious pungitious) and Alaska blackfish (Dallia pectoralis) were used to detect accumulation of these compounds in the local environment...
August 14, 2017: Environmental Pollution
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