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https://www.readbyqxmd.com/read/29780318/the-aerobic-and-cognitive-exercise-study-aces-for-community-dwelling-older-adults-with-or-at-risk-for-mild-cognitive-impairment-mci-neuropsychological-neurobiological-and-neuroimaging-outcomes-of-a-randomized-clinical-trial
#1
Cay Anderson-Hanley, Nicole M Barcelos, Earl A Zimmerman, Robert W Gillen, Mina Dunnam, Brian D Cohen, Vadim Yerokhin, Kenneth E Miller, David J Hayes, Paul J Arciero, Molly Maloney, Arthur F Kramer
Prior research has found that cognitive benefits of physical exercise and brain health in older adults may be enhanced when mental exercise is interactive simultaneously, as in exergaming. It is unclear whether the cognitive benefit can be maximized by increasing the degree of mental challenge during exercise. This randomized clinical trial (RCT), the Aerobic and Cognitive Exercise Study (ACES) sought to replicate and extend prior findings of added cognitive benefit from exergaming to those with or at risk for mild cognitive impairment (MCI)...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29773717/stk11-lkb1-mutations-and-pd-1-inhibitor-resistance-in-kras-mutant-lung-adenocarcinoma
#2
Ferdinandos Skoulidis, Michael E Goldberg, Danielle M Greenawalt, Matthew D Hellmann, Mark M Awad, Justin F Gainor, Alexa B Schrock, Ryan J Hartmaier, Sally E Trabucco, Laurie Gay, Siraj M Ali, Julia A Elvin, Gaurav Singal, Jeffrey S Ross, David Fabrizio, Peter M Szabo, Han Chang, Ariella Sasson, Sujaya Srinivasan, Stefan Kirov, Joseph Szustakowski, Patrik Vitazka, Robin Edwards, Jose A Bufill, Neelesh Sharma, Sai-Hong I Ou, Nir Peled, David R Spigel, Hira Rizvi, Elizabeth Jimenez Aguilar, Brett W Carter, Jeremy Erasmus, Darragh F Halpenny, Andrew J Plodkowski, Niamh M Long, Mizuki Nishino, Warren L Denning, Ana Galan-Cobo, Haifa Hamdi, Taghreed Hirz, Pan Tong, Jing Wang, Jaime Rodriguez-Canales, Pamela A Villalobos, Edwin R Parra, Neda Kalhor, Lynette M Sholl, Jennifer L Sauter, Achim A Jungbluth, Mari Mino-Kenudson, Roxana Azimi, Yasir Y Elamin, Jianjun Zhang, Giulia C Leonardi, Fei Jiang, Kwok-Kin Wong, J Jack Lee, Vassiliki A Papadimitrakopoulou, Ignacio I Wistuba, Vincent A Miller, Garrett M Frampton, Jedd D Wolchok, Alice T Shaw, Pasi A Jänne, Philip J Stephens, Charles M Rudin, William J Geese, Lee A Albacker, John V Heymach
KRAS is the most common oncogenic driver in lung adenocarcinoma (LUAC). We previously reported that STK11/LKB1 (KL) or TP53 (KP) co-mutations define distinct subgroups of KRAS-mutant LUAC. Here, we examine the efficacy of PD-1 inhibitors in these subgroups. Objective response rates to PD-1 blockade differed significantly among KL (7.4%), KP (35.7%), and K-only (28.6%) subgroups (P<0.001) in the SU2C cohort (174 patients) with KRAS-mutant LUAC and in patients treated with nivolumab in the CheckMate-057 phase 3 trial (0% vs 57...
May 17, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29773331/novel-use-of-viewray-mri-guidance-for-high-dose-rate-brachytherapy-in-the-treatment-of-cervical-cancer
#3
Huaising C Ko, Jessie Y Huang, Jessica R Miller, Rupak K Das, Charles R Wallace, Anna-Maria A De Costa, David M Francis, Margaret R Straub, Bethany M Anderson, Kristin A Bradley
PURPOSE: To characterize image quality and feasibility of using ViewRay MRI (VR)-guided brachytherapy planning for cervical cancer. METHODS AND MATERIALS: Cervical cancer patients receiving intracavitary brachytherapy with tandem and ovoids, planned using 0.35T VR MRI at our institution, were included in this series. The high-risk clinical target volume (HR-CTV), visible gross tumor volume, bladder, sigmoid, bowel, and rectum contours for each fraction of brachytherapy were evaluated for dosimetric parameters...
May 14, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29772478/bacillus-thuringiensis-cry5b-protein-as-a-new-pan-hookworm-cure
#4
Yan Hu, Thanh-Thanh Nguyen, Alice C Y Lee, Joseph F Urban, Melanie M Miller, Bin Zhan, David J Koch, Jason B Noon, Ambily Abraham, Ricardo Toshio Fujiwara, Dwight D Bowman, Gary R Ostroff, Raffi V Aroian
Hookworms are intestinal nematode parasites that infect nearly half a billion people and are globally one of the most important contributors to iron-deficiency anemia. These parasites have significant impacts in developing children, pregnant women and working adults. Of all the soil-transmitted helminths or nematodes (STNs), hookworms are by far the most important, with disease burdens conservatively estimated at four million DALYs (Disability-Adjusted Life Years) and with productivity losses of up to US$139 billion annually...
May 4, 2018: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29768650/gestation-at-birth-mode-of-birth-infant-feeding-and-childhood-hospitalization-with-infection
#5
Jason P Bentley, David P Burgner, Antonia W Shand, Jane C Bell, Jessica E Miller, Natasha Nassar
INTRODUCTION: Infections are a leading cause of mortality and morbidity in preschool children. We aimed to assess the impact of the co-occurrence of cesarean section, early birth and formula feeding on hospitalization with infection in early childhood. MATERIAL AND METHODS: Population-based retrospective record-linkage cohort study of 488 603 singleton livebirths ≥32 weeks gestational age in New South Wales, Australia, 2007-2012. Multivariable Cox-regression was used to estimate independent and combined adjusted associations of gestational age, mode of birth (vaginal or cesarean section by labor onset) and formula feeding with time to first and repeat hospitalization with infection for children <5 years of age...
May 16, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29767283/correction-to-multi-institutional-analysis-of-ct-and-mri-reports-evaluating-indeterminate-renal-masses-comparison-to-a-national-survey-investigating-desired-report-elements
#6
Eric M Hu, Andrew Zhang, Stuart G Silverman, Ivan Pedrosa, Zhen J Wang, Andrew D Smith, Hersh Chandarana, Ankur Doshi, Atul B Shinagare, Erick M Remer, Samuel D Kaffenberger, David C Miller, Matthew S Davenport
The original version of this article contained an error in author name. The co-author's name was published as Ivan M. Pedrosa, instead it should be Ivan Pedrosa. The original article has been corrected.
May 16, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29767272/the-esska-afas-international-consensus-statement-on-peroneal-tendon-pathologies
#7
REVIEW
Pim A van Dijk, David Miller, James Calder, Christopher W DiGiovanni, John G Kennedy, Gino M Kerkhoffs, Akos Kynsburtg, Daniel Havercamp, Stephane Guillo, Xavier M Oliva, Chris J Pearce, Helder Pereira, Pietro Spennacchio, Joanna M Stephen, C Niek van Dijk
INTRODUCTION: Peroneal tendon injuries are a significant cause of lateral ankle symptoms in the active population. Accurate diagnosis and prompt treatment is important for minimizing the risk of long-term sequelae associated with chronic peroneal tendinopathy. Although several studies have been published on diagnostic strategies and treatment outcomes, there is no consensus on the optimal management of peroneal tendon pathologies. PURPOSE: The purpose of this ESSKA-AFAS consensus statement was to conduct an international and multidisciplinary agreed guideline on management of patients with peroneal tendon pathologies...
May 16, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29761121/poly-gp-neurofilament-and-grey-matter-deficits-in-c9orf72-expansion-carriers
#8
Lieke H H Meeter, Tania F Gendron, Ana C Sias, Lize C Jiskoot, Silvia P Russo, Laura Donker Kaat, Janne M Papma, Jessica L Panman, Emma L van der Ende, Elise G Dopper, Sanne Franzen, Caroline Graff, Adam L Boxer, Howard J Rosen, Raquel Sanchez-Valle, Daniela Galimberti, Yolande A L Pijnenburg, Luisa Benussi, Roberta Ghidoni, Barbara Borroni, Robert Laforce, Marta Del Campo, Charlotte E Teunissen, Rick van Minkelen, Julio C Rojas, Giovanni Coppola, Dan H Geschwind, Rosa Rademakers, Anna M Karydas, Linn Öijerstedt, Elio Scarpini, Giuliano Binetti, Alessandro Padovani, David M Cash, Katrina M Dick, Martina Bocchetta, Bruce L Miller, Jonathan D Rohrer, Leonard Petrucelli, John C van Swieten, Suzee E Lee
Objective: To evaluate poly(GP), a dipeptide repeat protein, and neurofilament light chain (NfL) as biomarkers in presymptomatic C9orf72 repeat expansion carriers and patients with C9orf72- associated frontotemporal dementia. Additionally, to investigate the relationship of poly(GP) with indicators of neurodegeneration as measured by NfL and grey matter volume. Methods: We measured poly(GP) and NfL levels in cerebrospinal fluid (CSF) from 25 presymptomatic C9orf72 expansion carriers, 64 symptomatic expansion carriers with dementia, and 12 noncarriers...
May 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29758282/stevens-johnson-syndrome-toxic-epidermal-necrolysis-a-multicenter-retrospective-study-of-377-adult-patients-from-the-united-states
#9
Robert G Micheletti, Zelma Chiesa-Fuxench, Megan H Noe, Sasha Stephen, Maria Aleshin, Ashwin Agarwal, Jennifer Boggs, Adela R Cardones, Jennifer K Chen, Jonathan Cotliar, Mark Dp Davis, Arturo Dominguez, Lindy P Fox, Shayna Gordon, Ronald Hamrick, Baran Ho, Lauren C Hughey, Larry M Jones, Benjamin H Kaffenberger, Kimball Kindley, Daniela Kroshinsky, Bernice Y Kwong, Daniel D Miller, Arash Mostaghimi, Amy Musiek, Alex G Ortega-Loayza, Raj Patel, Alba Posligua, Monica Rani, Sandeep Saluja, Victoria R Sharon, Kanade Shinkai, Jessica St John, Nicole Strickland, Erika M Summers, Natalie Sun, Karolyn A Wanat, David A Wetter, Scott Worswick, Caroline Yang, David J Margolis, Joel M Gelfand, Misha Rosenbach
Stevens-Johnson syndrome / toxic epidermal necrolysis (SJS/TEN) is a rare, severe mucocutaneous reaction with few large cohorts reported. This multicenter retrospective study included patients with SJS/TEN seen by inpatient consultative dermatologists at 18 academic medical centers in the United States. 377 adult patients with SJS/TEN between 1/1/2000 and 6/1/2015 were entered, including 69.0% from 2010 onward. The most frequent cause of SJS/TEN was medication reaction (89.7%), most often trimethoprim / sulfamethoxazole (27...
May 11, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29756910/search-for-high-mass-resonances-decaying-to-%C3%AF-%C3%AE-in-pp-collisions-at-sqrt-s-13-tev-with-the-atlas-detector
#10
M Aaboud, G Aad, B Abbott, O Abdinov, B Abeloos, S H Abidi, O S AbouZeid, N L Abraham, H Abramowicz, H Abreu, Y Abulaiti, B S Acharya, S Adachi, L Adamczyk, J Adelman, M Adersberger, T Adye, A A Affolder, Y Afik, C Agheorghiesei, J A Aguilar-Saavedra, S P Ahlen, F Ahmadov, G Aielli, S Akatsuka, T P A Åkesson, E Akilli, A V Akimov, G L Alberghi, J Albert, P Albicocco, M J Alconada Verzini, S Alderweireldt, M Aleksa, I N Aleksandrov, C Alexa, G Alexander, T Alexopoulos, M Alhroob, B Ali, M Aliev, G Alimonti, J Alison, S P Alkire, C Allaire, B M M Allbrooke, B W Allen, P P Allport, A Aloisio, A Alonso, F Alonso, C Alpigiani, A A Alshehri, M I Alstaty, B Alvarez Gonzalez, D Álvarez Piqueras, M G Alviggi, B T Amadio, Y Amaral Coutinho, L Ambroz, C Amelung, D Amidei, S P Amor Dos Santos, S Amoroso, C S Amrouche, C Anastopoulos, L S Ancu, N Andari, T Andeen, C F Anders, J K Anders, K J Anderson, A Andreazza, V Andrei, S Angelidakis, I Angelozzi, A Angerami, A V Anisenkov, A Annovi, C Antel, M T Anthony, M Antonelli, D J Antrim, F Anulli, M Aoki, L Aperio Bella, G Arabidze, Y Arai, J P Araque, V Araujo Ferraz, R Araujo Pereira, A T H Arce, R E Ardell, F A Arduh, J-F Arguin, S Argyropoulos, A J Armbruster, L J Armitage, O Arnaez, H Arnold, M Arratia, O Arslan, A Artamonov, G Artoni, S Artz, S Asai, N Asbah, A Ashkenazi, E M Asimakopoulou, L Asquith, K Assamagan, R Astalos, R J Atkin, M Atkinson, N B Atlay, K Augsten, G Avolio, R Avramidou, B Axen, M K Ayoub, G Azuelos, A E Baas, M J Baca, H Bachacou, K Bachas, M Backes, P Bagnaia, M Bahmani, H Bahrasemani, J T Baines, M Bajic, O K Baker, P J Bakker, D Bakshi Gupta, E M Baldin, P Balek, F Balli, W K Balunas, E Banas, A Bandyopadhyay, Sw Banerjee, A A E Bannoura, L Barak, W M Barbe, E L Barberio, D Barberis, M Barbero, T Barillari, M-S Barisits, J T Barkeloo, T Barklow, N Barlow, R Barnea, S L Barnes, B M Barnett, R M Barnett, Z Barnovska-Blenessy, A Baroncelli, G Barone, A J Barr, L Barranco Navarro, F Barreiro, J Barreiro Guimarães da Costa, R Bartoldus, A E Barton, P Bartos, A Basalaev, A Bassalat, R L Bates, S J Batista, J R Batley, M Battaglia, M Bauce, F Bauer, K T Bauer, H S Bawa, J B Beacham, M D Beattie, T Beau, P H Beauchemin, P Bechtle, H P Beck, H C Beck, K Becker, M Becker, C Becot, A J Beddall, A Beddall, V A Bednyakov, M Bedognetti, C P Bee, T A Beermann, M Begalli, M Begel, A Behera, J K Behr, A S Bell, G Bella, L Bellagamba, A Bellerive, M Bellomo, K Belotskiy, N L Belyaev, O Benary, D Benchekroun, M Bender, N Benekos, Y Benhammou, E Benhar Noccioli, J Benitez, D P Benjamin, M Benoit, J R Bensinger, S Bentvelsen, L Beresford, M Beretta, D Berge, E Bergeaas Kuutmann, N Berger, L J Bergsten, J Beringer, S Berlendis, N R Bernard, G Bernardi, C Bernius, F U Bernlochner, T Berry, P Berta, C Bertella, G Bertoli, I A Bertram, C Bertsche, G J Besjes, O Bessidskaia Bylund, M Bessner, N Besson, A Bethani, S Bethke, A Betti, A J Bevan, J Beyer, R M Bianchi, O Biebel, D Biedermann, R Bielski, K Bierwagen, N V Biesuz, M Biglietti, T R V Billoud, M Bindi, A Bingul, C Bini, S Biondi, T Bisanz, C Bittrich, D M Bjergaard, J E Black, K M Black, R E Blair, T Blazek, I Bloch, C Blocker, A Blue, U Blumenschein, Dr Blunier, G J Bobbink, V S Bobrovnikov, S S Bocchetta, A Bocci, C Bock, D Boerner, D Bogavac, A G Bogdanchikov, C Bohm, V Boisvert, P Bokan, T Bold, A S Boldyrev, A E Bolz, M Bomben, M Bona, J S Bonilla, M Boonekamp, A Borisov, G Borissov, J Bortfeldt, D Bortoletto, V Bortolotto, D Boscherini, M Bosman, J D Bossio Sola, J Boudreau, E V Bouhova-Thacker, D Boumediene, C Bourdarios, S K Boutle, A Boveia, J Boyd, I R Boyko, A J Bozson, J Bracinik, N Brahimi, A Brandt, G Brandt, O Brandt, F Braren, U Bratzler, B Brau, J E Brau, W D Breaden Madden, K Brendlinger, A J Brennan, L Brenner, R Brenner, S Bressler, D L Briglin, T M Bristow, D Britton, D Britzger, I Brock, R Brock, G Brooijmans, T Brooks, W K Brooks, E Brost, J H Broughton, P A Bruckman de Renstrom, D Bruncko, A Bruni, G Bruni, L S Bruni, S Bruno, B H Brunt, M Bruschi, N Bruscino, P Bryant, L Bryngemark, T Buanes, Q Buat, P Buchholz, A G Buckley, I A Budagov, F Buehrer, M K Bugge, O Bulekov, D Bullock, T J Burch, S Burdin, C D Burgard, A M Burger, B Burghgrave, K Burka, S Burke, I Burmeister, J T P Burr, D Büscher, V Büscher, E Buschmann, P Bussey, J M Butler, C M Buttar, J M Butterworth, P Butti, W Buttinger, A Buzatu, A R Buzykaev, G Cabras, S Cabrera Urbán, D Caforio, H Cai, V M M Cairo, O Cakir, N Calace, P Calafiura, A Calandri, G Calderini, P Calfayan, G Callea, L P Caloba, S Calvente Lopez, D Calvet, S Calvet, T P Calvet, M Calvetti, R Camacho Toro, S Camarda, P Camarri, D Cameron, R Caminal Armadans, C Camincher, S Campana, M Campanelli, A Camplani, A Campoverde, V Canale, M Cano Bret, J Cantero, T Cao, Y Cao, M D M Capeans Garrido, I Caprini, M Caprini, M Capua, R M Carbone, R Cardarelli, F Cardillo, I Carli, T Carli, G Carlino, B T Carlson, L Carminati, R M D Carney, S Caron, E Carquin, S Carrá, G D Carrillo-Montoya, D Casadei, M P Casado, A F Casha, M Casolino, D W Casper, R Castelijn, V Castillo Gimenez, N F Castro, A Catinaccio, J R Catmore, A Cattai, J Caudron, V Cavaliere, E Cavallaro, D Cavalli, M Cavalli-Sforza, V Cavasinni, E Celebi, F Ceradini, L Cerda Alberich, A S Cerqueira, A Cerri, L Cerrito, F Cerutti, A Cervelli, S A Cetin, A Chafaq, D Chakraborty, S K Chan, W S Chan, Y L Chan, P Chang, J D Chapman, D G Charlton, C C Chau, C A Chavez Barajas, S Che, A Chegwidden, S Chekanov, S V Chekulaev, G A Chelkov, M A Chelstowska, C Chen, C Chen, H Chen, J Chen, J Chen, S Chen, S Chen, X Chen, Y Chen, Y-H Chen, H C Cheng, H J Cheng, A Cheplakov, E Cheremushkina, R Cherkaoui El Moursli, E Cheu, K Cheung, L Chevalier, V Chiarella, G Chiarelli, G Chiodini, A S Chisholm, A Chitan, I Chiu, Y H Chiu, M V Chizhov, K Choi, A R Chomont, S Chouridou, Y S Chow, V Christodoulou, M C Chu, J Chudoba, A J Chuinard, J J Chwastowski, L Chytka, D Cinca, V Cindro, I A Cioară, A Ciocio, F Cirotto, Z H Citron, M Citterio, A Clark, M R Clark, P J Clark, R N Clarke, C Clement, Y Coadou, M Cobal, A Coccaro, J Cochran, L Colasurdo, B Cole, A P Colijn, J Collot, P Conde Muiño, E Coniavitis, S H Connell, I A Connelly, S Constantinescu, F Conventi, A M Cooper-Sarkar, F Cormier, K J R Cormier, M Corradi, E E Corrigan, F Corriveau, A Cortes-Gonzalez, M J Costa, D Costanzo, G Cottin, G Cowan, B E Cox, J Crane, K Cranmer, S J Crawley, R A Creager, G Cree, S Crépé-Renaudin, F Crescioli, M Cristinziani, V Croft, G Crosetti, A Cueto, T Cuhadar Donszelmann, A R Cukierman, M Curatolo, J Cúth, S Czekierda, P Czodrowski, G D'amen, S D'Auria, L D'eramo, M D'Onofrio, M J Da Cunha Sargedas De Sousa, C Da Via, W Dabrowski, T Dado, S Dahbi, T Dai, O Dale, F Dallaire, C Dallapiccola, M Dam, J R Dandoy, M F Daneri, N P Dang, N S Dann, M Danninger, V Dao, G Darbo, S Darmora, O Dartsi, A Dattagupta, T Daubney, W Davey, C David, T Davidek, D R Davis, E Dawe, I Dawson, K De, R de Asmundis, A De Benedetti, S De Castro, S De Cecco, N De Groot, P de Jong, H De la Torre, F De Lorenzi, A De Maria, D De Pedis, A De Salvo, U De Sanctis, A De Santo, K De Vasconcelos Corga, J B De Vivie De Regie, C Debenedetti, D V Dedovich, N Dehghanian, M Del Gaudio, J Del Peso, D Delgove, F Deliot, C M Delitzsch, A Dell'Acqua, L Dell'Asta, M Della Pietra, D Della Volpe, M Delmastro, C Delporte, P A Delsart, D A DeMarco, S Demers, M Demichev, S P Denisov, D Denysiuk, D Derendarz, J E Derkaoui, F Derue, P Dervan, K Desch, C Deterre, K Dette, M R Devesa, P O Deviveiros, A Dewhurst, S Dhaliwal, F A Di Bello, A Di Ciaccio, L Di Ciaccio, W K Di Clemente, C Di Donato, A Di Girolamo, B Di Micco, R Di Nardo, K F Di Petrillo, A Di Simone, R Di Sipio, D Di Valentino, C Diaconu, M Diamond, F A Dias, T Dias do Vale, M A Diaz, J Dickinson, E B Diehl, J Dietrich, S Díez Cornell, A Dimitrievska, J Dingfelder, F Dittus, F Djama, T Djobava, J I Djuvsland, M A B do Vale, M Dobre, D Dodsworth, C Doglioni, J Dolejsi, Z Dolezal, M Donadelli, J Donini, J Dopke, A Doria, M T Dova, A T Doyle, E Drechsler, E Dreyer, T Dreyer, M Dris, Y Du, J Duarte-Campderros, F Dubinin, A Dubreuil, E Duchovni, G Duckeck, A Ducourthial, O A Ducu, D Duda, A Dudarev, A Chr Dudder, E M Duffield, L Duflot, M Dührssen, C Dulsen, M Dumancic, A E Dumitriu, A K Duncan, M Dunford, A Duperrin, H Duran Yildiz, M Düren, A Durglishvili, D Duschinger, B Dutta, D Duvnjak, M Dyndal, B S Dziedzic, C Eckardt, K M Ecker, R C Edgar, T Eifert, G Eigen, K Einsweiler, T Ekelof, M El Kacimi, R El Kosseifi, V Ellajosyula, M Ellert, F Ellinghaus, A A Elliot, N Ellis, J Elmsheuser, M Elsing, D Emeliyanov, Y Enari, J S Ennis, M B Epland, J Erdmann, A Ereditato, S Errede, M Escalier, C Escobar, B Esposito, O Estrada Pastor, A I Etienvre, E Etzion, H Evans, A Ezhilov, M Ezzi, F Fabbri, L Fabbri, V Fabiani, G Facini, R M Fakhrutdinov, S Falciano, P J Falke, S Falke, J Faltova, Y Fang, M Fanti, A Farbin, A Farilla, E M Farina, T Farooque, S Farrell, S M Farrington, P Farthouat, F Fassi, P Fassnacht, D Fassouliotis, M Faucci Giannelli, A Favareto, W J Fawcett, L Fayard, O L Fedin, W Fedorko, M Feickert, S Feigl, L Feligioni, C Feng, E J Feng, M Feng, M J Fenton, A B Fenyuk, L Feremenga, J Ferrando, A Ferrari, P Ferrari, R Ferrari, D E Ferreira de Lima, A Ferrer, D Ferrere, C Ferretti, F Fiedler, A Filipčič, F Filthaut, M Fincke-Keeler, K D Finelli, M C N Fiolhais, L Fiorini, C Fischer, J Fischer, W C Fisher, N Flaschel, I Fleck, P Fleischmann, R R M Fletcher, T Flick, B M Flierl, L M Flores, L R Flores Castillo, N Fomin, G T Forcolin, A Formica, F A Förster, A Forti, A G Foster, D Fournier, H Fox, S Fracchia, P Francavilla, M Franchini, S Franchino, D Francis, L Franconi, M Franklin, M Frate, M Fraternali, D Freeborn, S M Fressard-Batraneanu, B Freund, W S Freund, D Froidevaux, J A Frost, C Fukunaga, T Fusayasu, J Fuster, O Gabizon, A Gabrielli, A Gabrielli, G P Gach, S Gadatsch, S Gadomski, P Gadow, G Gagliardi, L G Gagnon, C Galea, B Galhardo, E J Gallas, B J Gallop, P Gallus, G Galster, R Gamboa Goni, K K Gan, S Ganguly, Y Gao, Y S Gao, F M Garay Walls, C García, J E García Navarro, J A García Pascual, M Garcia-Sciveres, R W Gardner, N Garelli, V Garonne, K Gasnikova, A Gaudiello, G Gaudio, I L Gavrilenko, A Gavrilyuk, C Gay, G Gaycken, E N Gazis, C N P Gee, J Geisen, M Geisen, M P Geisler, K Gellerstedt, C Gemme, M H Genest, C Geng, S Gentile, C Gentsos, S George, D Gerbaudo, G Geßner, S Ghasemi, M Ghneimat, B Giacobbe, S Giagu, N Giangiacomi, P Giannetti, S M Gibson, M Gignac, D Gillberg, G Gilles, D M Gingrich, M P Giordani, F M Giorgi, P F Giraud, P Giromini, G Giugliarelli, D Giugni, F Giuli, M Giulini, S Gkaitatzis, I Gkialas, E L Gkougkousis, P Gkountoumis, L K Gladilin, C Glasman, J Glatzer, P C F Glaysher, A Glazov, M Goblirsch-Kolb, J Godlewski, S Goldfarb, T Golling, D Golubkov, A Gomes, R Gonçalo, R Goncalves Gama, G Gonella, L Gonella, A Gongadze, F Gonnella, J L Gonski, S González de la Hoz, S Gonzalez-Sevilla, L Goossens, P A Gorbounov, H A Gordon, B Gorini, E Gorini, A Gorišek, A T Goshaw, C Gössling, M I Gostkin, C A Gottardo, C R Goudet, D Goujdami, A G Goussiou, N Govender, C Goy, E Gozani, I Grabowska-Bold, P O J Gradin, E C Graham, J Gramling, E Gramstad, S Grancagnolo, V Gratchev, P M Gravila, C Gray, H M Gray, Z D Greenwood, C Grefe, K Gregersen, I M Gregor, P Grenier, K Grevtsov, J Griffiths, A A Grillo, K Grimm, S Grinstein, Ph Gris, J-F Grivaz, S Groh, E Gross, J Grosse-Knetter, G C Grossi, Z J Grout, A Grummer, L Guan, W Guan, J Guenther, A Guerguichon, F Guescini, D Guest, O Gueta, R Gugel, B Gui, T Guillemin, S Guindon, U Gul, C Gumpert, J Guo, W Guo, Y Guo, R Gupta, S Gurbuz, G Gustavino, B J Gutelman, P Gutierrez, N G Gutierrez Ortiz, C Gutschow, C Guyot, M P Guzik, C Gwenlan, C B Gwilliam, A Haas, C Haber, H K Hadavand, N Haddad, A Hadef, S Hageböck, M Hagihara, H Hakobyan, M Haleem, J Haley, G Halladjian, G D Hallewell, K Hamacher, P Hamal, K Hamano, A 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Sulin, Dms Sultan, S Sultansoy, T Sumida, S Sun, X Sun, K Suruliz, C J E Suster, M R Sutton, S Suzuki, M Svatos, M Swiatlowski, S P Swift, A Sydorenko, I Sykora, T Sykora, D Ta, K Tackmann, J Taenzer, A Taffard, R Tafirout, E Tahirovic, N Taiblum, H Takai, R Takashima, E H Takasugi, K Takeda, T Takeshita, Y Takubo, M Talby, A A Talyshev, J Tanaka, M Tanaka, R Tanaka, R Tanioka, B B Tannenwald, S Tapia Araya, S Tapprogge, A T Tarek Abouelfadl Mohamed, S Tarem, G Tarna, G F Tartarelli, P Tas, M Tasevsky, T Tashiro, E Tassi, A Tavares Delgado, Y Tayalati, A C Taylor, A J Taylor, G N Taylor, P T E Taylor, W Taylor, P Teixeira-Dias, D Temple, H Ten Kate, P K Teng, J J Teoh, F Tepel, S Terada, K Terashi, J Terron, S Terzo, M Testa, R J Teuscher, S J Thais, T Theveneaux-Pelzer, F Thiele, J P Thomas, P D Thompson, A S Thompson, L A Thomsen, E Thomson, Y Tian, R E Ticse Torres, V O Tikhomirov, Yu A Tikhonov, S Timoshenko, P Tipton, S Tisserant, K Todome, S Todorova-Nova, S Todt, J Tojo, S Tokár, K Tokushuku, E Tolley, M Tomoto, L Tompkins, K Toms, B Tong, P Tornambe, E Torrence, H Torres, E Torró Pastor, C Tosciri, J Toth, F Touchard, D R Tovey, C J Treado, T Trefzger, F Tresoldi, A Tricoli, I M Trigger, S Trincaz-Duvoid, M F Tripiana, W Trischuk, B Trocmé, A Trofymov, C Troncon, M Trovatelli, F Trovato, L Truong, M Trzebinski, A Trzupek, F Tsai, K W Tsang, J C-L Tseng, P V Tsiareshka, N Tsirintanis, S Tsiskaridze, V Tsiskaridze, E G Tskhadadze, I I Tsukerman, V Tsulaia, S Tsuno, D Tsybychev, Y Tu, A Tudorache, V Tudorache, T T Tulbure, A N Tuna, S Turchikhin, D Turgeman, I Turk Cakir, R Turra, P M Tuts, G Ucchielli, I Ueda, M Ughetto, F Ukegawa, G Unal, A Undrus, G Unel, F C Ungaro, Y Unno, K Uno, J Urban, P Urquijo, P Urrejola, G Usai, J Usui, L Vacavant, V Vacek, B Vachon, K O H Vadla, A Vaidya, C Valderanis, E Valdes Santurio, M Valente, S Valentinetti, A Valero, L Valéry, R A Vallance, A Vallier, J A Valls Ferrer, T R Van Daalen, W Van Den Wollenberg, H van der Graaf, P van Gemmeren, J Van Nieuwkoop, I van Vulpen, M C van Woerden, M Vanadia, W Vandelli, A Vaniachine, P Vankov, R Vari, E W Varnes, C Varni, T Varol, D Varouchas, A Vartapetian, K E Varvell, J G Vasquez, G A Vasquez, F Vazeille, D Vazquez Furelos, T Vazquez Schroeder, J Veatch, V Vecchio, L M Veloce, F Veloso, S Veneziano, A Ventura, M Venturi, N Venturi, V Vercesi, M Verducci, C Vergis, W Verkerke, A T Vermeulen, J C Vermeulen, M C Vetterli, N Viaux Maira, O Viazlo, I Vichou, T Vickey, O E Vickey Boeriu, G H A Viehhauser, S Viel, L Vigani, M Villa, M Villaplana Perez, E Vilucchi, M G Vincter, V B Vinogradov, A Vishwakarma, C Vittori, I Vivarelli, S Vlachos, M Vogel, P Vokac, G Volpi, S E von Buddenbrock, E von Toerne, V Vorobel, K Vorobev, M Vos, J H Vossebeld, N Vranjes, M Vranjes Milosavljevic, V Vrba, M Vreeswijk, R Vuillermet, I Vukotic, P Wagner, W Wagner, J Wagner-Kuhr, H Wahlberg, S Wahrmund, K Wakamiya, J Walder, R Walker, W Walkowiak, V Wallangen, A M Wang, C Wang, F Wang, H Wang, H Wang, J Wang, J Wang, Q Wang, R-J Wang, R Wang, R Wang, S M Wang, T Wang, W Wang, W Wang, Y Wang, Z Wang, C Wanotayaroj, A Warburton, C P Ward, D R Wardrope, A Washbrook, P M Watkins, A T Watson, M F Watson, G Watts, S Watts, B M Waugh, A F Webb, S Webb, C Weber, M S Weber, S M Weber, S A Weber, J S Webster, A R Weidberg, B Weinert, J Weingarten, M Weirich, C Weiser, P S Wells, T Wenaus, T Wengler, S Wenig, N Wermes, M D Werner, P Werner, M Wessels, T D Weston, K Whalen, N L Whallon, A M Wharton, A S White, A White, M J White, R White, D Whiteson, B W Whitmore, F J Wickens, W Wiedenmann, M Wielers, C Wiglesworth, L A M Wiik-Fuchs, A Wildauer, F Wilk, H G Wilkens, H H Williams, S Williams, C Willis, S Willocq, J A Wilson, I Wingerter-Seez, E Winkels, F Winklmeier, O J Winston, B T Winter, M Wittgen, M Wobisch, A Wolf, T M H Wolf, R Wolff, M W Wolter, H Wolters, V W S Wong, N L Woods, S D Worm, B K Wosiek, K W Wozniak, K Wraight, M Wu, S L Wu, X Wu, Y Wu, T R Wyatt, B M Wynne, S Xella, Z Xi, L Xia, D Xu, H Xu, L Xu, T Xu, W Xu, B Yabsley, S Yacoob, K Yajima, D P Yallup, D Yamaguchi, Y Yamaguchi, A Yamamoto, T Yamanaka, F Yamane, M Yamatani, T Yamazaki, Y Yamazaki, Z Yan, H Yang, H Yang, S Yang, Y Yang, Y Yang, Z Yang, W-M Yao, Y C Yap, Y Yasu, E Yatsenko, K H Yau Wong, J Ye, S Ye, I Yeletskikh, E Yigitbasi, E Yildirim, K Yorita, K Yoshihara, C Young, C J S Young, J Yu, J Yu, X Yue, S P Y Yuen, I Yusuff, B Zabinski, G Zacharis, R Zaidan, A M Zaitsev, N Zakharchuk, J Zalieckas, S Zambito, D Zanzi, C Zeitnitz, G Zemaityte, J C Zeng, Q Zeng, O Zenin, T Ženiš, D Zerwas, M Zgubič, D Zhang, D Zhang, F Zhang, G Zhang, H Zhang, J Zhang, L Zhang, L Zhang, M Zhang, P Zhang, R Zhang, R Zhang, X Zhang, Y Zhang, Z Zhang, X Zhao, Y Zhao, Z Zhao, A Zhemchugov, B Zhou, C Zhou, L Zhou, M Zhou, M Zhou, N Zhou, Y Zhou, C G Zhu, H Zhu, H Zhu, J Zhu, Y Zhu, X Zhuang, K Zhukov, V Zhulanov, A Zibell, D Zieminska, N I Zimine, S Zimmermann, Z Zinonos, M Zinser, M Ziolkowski, L Živković, G Zobernig, A Zoccoli, K Zoch, T G Zorbas, R Zou, M Zur Nedden, L Zwalinski
A search for high-mass resonances decaying to τν using proton-proton collisions at sqrt[s]=13  TeV produced by the Large Hadron Collider is presented. Only τ-lepton decays with hadrons in the final state are considered. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 36.1  fb^{-1}. No statistically significant excess above the standard model expectation is observed; model-independent upper limits are set on the visible τν production cross section. Heavy W^{'} bosons with masses less than 3...
April 20, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29756455/characterization-of-the-transmitted-virus-in-an-ongoing-hiv-1-epidemic-driven-by-injecting-drug-use
#11
Elena Dukhovlinova, Alexey Masharsky, Aleksandra Vasileva, Alessandro Porrello, Shuntai Zhou, Olga Toussova, Sergei Verevochkin, Ekaterina Akulova, Dmitrij Frishman, David Montefiori, Celia Labranche, Irving Hoffman, William Miller, Myron S Cohen, Andrei Kozlov, Ronald Swanstrom
Understanding features of the HIV-1 transmission process have the potential to inform biological interventions for prevention. We have examined the transmitted virus in a cohort of people who inject drugs and who are at risk of HIV-1 infection through blood contamination when injecting in a group. This study focused on seven newly infected participants in St. Petersburg, Russia, who were in acute or early infection. We used end-point dilution PCR to amplify single viral genomes to assess the complexity of the transmitted virus...
May 14, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29753517/liberal-versus-restrictive-intravenous-fluid-therapy-for-early-septic-shock-rationale-for-a-randomized-trial
#12
Wesley H Self, Matthew W Semler, Rinaldo Bellomo, Samuel M Brown, Bennett P deBoisblanc, Matthew C Exline, Adit A Ginde, Colin K Grissom, David R Janz, Alan E Jones, Kathleen D Liu, Stephen P J Macdonald, Chadwick D Miller, Pauline K Park, Lora A Reineck, Todd W Rice, Jay S Steingrub, Daniel Talmor, Donald M Yealy, Ivor S Douglas, Nathan I Shapiro
Prompt intravenous fluid therapy is a fundamental treatment for patients with septic shock. However, the optimal approach for administering intravenous fluid in septic shock resuscitation is unknown. Two competing strategies are emerging: a liberal fluids approach, consisting of a larger volume of initial fluid (50 to 75 mL/kg [4 to 6 L in an 80-kg adult] during the first 6 hours) and later use of vasopressors, versus a restrictive fluids approach, consisting of a smaller volume of initial fluid (≤30 mL/kg [≤2 to 3 L]), with earlier reliance on vasopressor infusions to maintain blood pressure and perfusion...
May 9, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29748285/an-anatomic-transcriptional-atlas-of-human-glioblastoma
#13
Ralph B Puchalski, Nameeta Shah, Jeremy Miller, Rachel Dalley, Steve R Nomura, Jae-Guen Yoon, Kimberly A Smith, Michael Lankerovich, Darren Bertagnolli, Kris Bickley, Andrew F Boe, Krissy Brouner, Stephanie Butler, Shiella Caldejon, Mike Chapin, Suvro Datta, Nick Dee, Tsega Desta, Tim Dolbeare, Nadezhda Dotson, Amanda Ebbert, David Feng, Xu Feng, Michael Fisher, Garrett Gee, Jeff Goldy, Lindsey Gourley, Benjamin W Gregor, Guangyu Gu, Nika Hejazinia, John Hohmann, Parvinder Hothi, Robert Howard, Kevin Joines, Ali Kriedberg, Leonard Kuan, Chris Lau, Felix Lee, Hwahyung Lee, Tracy Lemon, Fuhui Long, Naveed Mastan, Erika Mott, Chantal Murthy, Kiet Ngo, Eric Olson, Melissa Reding, Zack Riley, David Rosen, David Sandman, Nadiya Shapovalova, Clifford R Slaughterbeck, Andrew Sodt, Graham Stockdale, Aaron Szafer, Wayne Wakeman, Paul E Wohnoutka, Steven J White, Don Marsh, Robert C Rostomily, Lydia Ng, Chinh Dang, Allan Jones, Bart Keogh, Haley R Gittleman, Jill S Barnholtz-Sloan, Patrick J Cimino, Megha S Uppin, C Dirk Keene, Farrokh R Farrokhi, Justin D Lathia, Michael E Berens, Antonio Iavarone, Amy Bernard, Ed Lein, John W Phillips, Steven W Rostad, Charles Cobbs, Michael J Hawrylycz, Greg D Foltz
Glioblastoma is an aggressive brain tumor that carries a poor prognosis. The tumor's molecular and cellular landscapes are complex, and their relationships to histologic features routinely used for diagnosis are unclear. We present the Ivy Glioblastoma Atlas, an anatomically based transcriptional atlas of human glioblastoma that aligns individual histologic features with genomic alterations and gene expression patterns, thus assigning molecular information to the most important morphologic hallmarks of the tumor...
May 11, 2018: Science
https://www.readbyqxmd.com/read/29746190/criterion-a-of-the-ampd-in-hitop
#14
Thomas A Widiger, Bo Bach, Michael Chmielewski, Lee Anna Clark, Colin DeYoung, Christopher J Hopwood, Roman Kotov, Robert F Krueger, Joshua D Miller, Leslie C Morey, Stephanie N Mullins-Sweatt, Christopher J Patrick, Aaron L Pincus, Douglas B Samuel, Martin Sellbom, Susan C South, Jennifer L Tackett, David Watson, Mark H Waugh, Aidan G C Wright, Johannes Zimmermann, R Michael Bagby, David C Cicero, Christopher C Conway, Barbara De Clercq, Anna R Docherty, Nicholas R Eaton, Kelsie T Forbush, J D Haltigan, Masha Y Ivanova, Robert D Latzman, Donald R Lynam, Kristian E Markon, Ulrich Reininghaus, Katherine M Thomas
The categorical model of personality disorder classification in the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (5th ed. [DSM-5]; American Psychiatric Association, 2013 ) is highly and fundamentally problematic. Proposed for DSM-5 and provided within Section III (for Emerging Measures and Models) was the Alternative Model of Personality Disorder (AMPD) classification, consisting of Criterion A (self-interpersonal deficits) and Criterion B (maladaptive personality traits)...
May 10, 2018: Journal of Personality Assessment
https://www.readbyqxmd.com/read/29737954/-90-y-radioembolization-for-hepatic-malignancy-in-patients-with-previous-biliary-intervention-multicenter-analysis-of-hepatobiliary-infections
#15
Kavi K Devulapalli, Nicholas Fidelman, Michael C Soulen, Matthew Miller, Matthew S Johnson, Eric Addo, Ghassan El-Haddad, Charles Nutting, James Morrison, Khashayar Farsad, R Peter Lokken, Ron C Gaba, Jacob Fleming, Daniel B Brown, Sharon W Kwan, Steven C Rose, Kevin A Pennycooke, David M Liu, Sarah B White, Ripal Gandhi, Ann A Lazar, Robert K Kerlan
Purpose To determine the frequency of hepatobiliary infections after transarterial radioembolization (TARE) with yttrium 90 (90 Y) in patients with liver malignancy and a history of biliary intervention. Materials and Methods For this retrospective study, records of all consecutive patients with liver malignancy and history of biliary intervention treated with TARE at 14 centers between 2005 and 2015 were reviewed. Data regarding liver function, 90 Y dosimetry, antibiotic prophylaxis, and bowel preparation prophylaxis were collected...
May 8, 2018: Radiology
https://www.readbyqxmd.com/read/29724592/potential-genetic-modifiers-of-disease-risk-and-age-at-onset-in-patients-with-frontotemporal-lobar-degeneration-and-grn-mutations-a-genome-wide-association-study
#16
Cyril Pottier, Xiaolai Zhou, Ralph B Perkerson, Matt Baker, Gregory D Jenkins, Daniel J Serie, Roberta Ghidoni, Luisa Benussi, Giuliano Binetti, Adolfo López de Munain, Miren Zulaica, Fermin Moreno, Isabelle Le Ber, Florence Pasquier, Didier Hannequin, Raquel Sánchez-Valle, Anna Antonell, Albert Lladó, Tammee M Parsons, NiCole A Finch, Elizabeth C Finger, Carol F Lippa, Edward D Huey, Manuela Neumann, Peter Heutink, Matthis Synofzik, Carlo Wilke, Robert A Rissman, Jaroslaw Slawek, Emilia Sitek, Peter Johannsen, Jørgen E Nielsen, Yingxue Ren, Marka van Blitterswijk, Mariely DeJesus-Hernandez, Elizabeth Christopher, Melissa E Murray, Kevin F Bieniek, Bret M Evers, Camilla Ferrari, Sara Rollinson, Anna Richardson, Elio Scarpini, Giorgio G Fumagalli, Alessandro Padovani, John Hardy, Parastoo Momeni, Raffaele Ferrari, Francesca Frangipane, Raffaele Maletta, Maria Anfossi, Maura Gallo, Leonard Petrucelli, EunRan Suh, Oscar L Lopez, Tsz H Wong, Jeroen G J van Rooij, Harro Seelaar, Simon Mead, Richard J Caselli, Eric M Reiman, Marwan Noel Sabbagh, Mads Kjolby, Anders Nykjaer, Anna M Karydas, Adam L Boxer, Lea T Grinberg, Jordan Grafman, Salvatore Spina, Adrian Oblak, M-Marsel Mesulam, Sandra Weintraub, Changiz Geula, John R Hodges, Olivier Piguet, William S Brooks, David J Irwin, John Q Trojanowski, Edward B Lee, Keith A Josephs, Joseph E Parisi, Nilüfer Ertekin-Taner, David S Knopman, Benedetta Nacmias, Irene Piaceri, Silvia Bagnoli, Sandro Sorbi, Marla Gearing, Jonathan Glass, Thomas G Beach, Sandra E Black, Mario Masellis, Ekaterina Rogaeva, Jean-Paul Vonsattel, Lawrence S Honig, Julia Kofler, Amalia C Bruni, Julie Snowden, David Mann, Stuart Pickering-Brown, Janine Diehl-Schmid, Juliane Winkelmann, Daniela Galimberti, Caroline Graff, Linn Öijerstedt, Claire Troakes, Safa Al-Sarraj, Carlos Cruchaga, Nigel J Cairns, Jonathan D Rohrer, Glenda M Halliday, John B Kwok, John C van Swieten, Charles L White, Bernardino Ghetti, Jill R Murell, Ian R A Mackenzie, Ging-Yuek R Hsiung, Barbara Borroni, Giacomina Rossi, Fabrizio Tagliavini, Zbigniew K Wszolek, Ronald C Petersen, Eileen H Bigio, Murray Grossman, Vivianna M Van Deerlin, William W Seeley, Bruce L Miller, Neill R Graff-Radford, Bradley F Boeve, Dennis W Dickson, Joanna M Biernacka, Rosa Rademakers
BACKGROUND: Loss-of-function mutations in GRN cause frontotemporal lobar degeneration (FTLD). Patients with GRN mutations present with a uniform subtype of TAR DNA-binding protein 43 (TDP-43) pathology at autopsy (FTLD-TDP type A); however, age at onset and clinical presentation are variable, even within families. We aimed to identify potential genetic modifiers of disease onset and disease risk in GRN mutation carriers. METHODS: The study was done in three stages: a discovery stage, a replication stage, and a meta-analysis of the discovery and replication data...
April 30, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29721622/monitoring-concentration-and-isotopic-composition-of-methane-in-groundwater-in-the-utica-shale-hydraulic-fracturing-region-of-ohio
#17
E Claire Botner, Amy Townsend-Small, David B Nash, Xiaomei Xu, Arndt Schimmelmann, Joshua H Miller
Degradation of groundwater quality is a primary public concern in rural hydraulic fracturing areas. Previous studies have shown that natural gas methane (CH4 ) is present in groundwater near shale gas wells in the Marcellus Shale of Pennsylvania, but did not have pre-drilling baseline measurements. Here, we present the results of a free public water testing program in the Utica Shale of Ohio, where we measured CH4 concentration, CH4 stable isotopic composition, and pH and conductivity along temporal and spatial gradients of hydraulic fracturing activity...
May 3, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29719225/a-potent-and-specific-cd38-inhibitor-ameliorates-age-related-metabolic-dysfunction-by-reversing-tissue-nad-decline
#18
Mariana G Tarragó, Claudia C S Chini, Karina S Kanamori, Gina M Warner, Ariel Caride, Guilherme C de Oliveira, Micaela Rud, Adrienne Samani, Kyaw Z Hein, Runqing Huang, Diana Jurk, Dong Seong Cho, James J Boslett, Jordan D Miller, Jay L Zweier, João F Passos, Jason D Doles, David J Becherer, Eduardo N Chini
Aging is characterized by the development of metabolic dysfunction and frailty. Recent studies show that a reduction in nicotinamide adenine dinucleotide (NAD+ ) is a key factor for the development of age-associated metabolic decline. We recently demonstrated that the NADase CD38 has a central role in age-related NAD+ decline. Here we show that a highly potent and specific thiazoloquin(az)olin(on)e CD38 inhibitor, 78c, reverses age-related NAD+ decline and improves several physiological and metabolic parameters of aging, including glucose tolerance, muscle function, exercise capacity, and cardiac function in mouse models of natural and accelerated aging...
May 1, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29698444/formalin-fixation-increases-deamination-mutation-signature-but-should-not-lead-to-false-positive-mutations-in-clinical-practice
#19
Leah M Prentice, Ruth R Miller, Jeff Knaggs, Alborz Mazloomian, Rosalia Aguirre Hernandez, Patrick Franchini, Kourosh Parsa, Basile Tessier-Cloutier, Anna Lapuk, David Huntsman, David F Schaeffer, Brandon S Sheffield
Genomic analysis of cancer tissues is an essential aspect of personalized oncology treatment. Though it has been suggested that formalin fixation of patient tissues may be suboptimal for molecular studies, this tissue processing approach remains the industry standard. Therefore clinical molecular laboratories must be able to work with formalin fixed, paraffin embedded (FFPE) material. This study examines the effects of pre-analytic variables introduced by routine pathology processing on specimens used for clinical reports produced by next-generation sequencing technology...
2018: PloS One
https://www.readbyqxmd.com/read/29695324/detection-of-mycobacterium-bovis-infection-in-african-buffaloes-syncerus-caffer-using-quantiferon-%C3%A2-tb-gold-qft-tubes-and-the-qiagen-cattletype-%C3%A2-ifn-gamma-elisa
#20
Netanya Bernitz, Charlene Clarke, Eduard O Roos, Wynand J Goosen, David Cooper, Paul D van Helden, Sven D C Parsons, Michele A Miller
African buffaloes (Syncerus caffer) are wildlife maintenance hosts of Mycobacterium bovis, the cause of bovine tuberculosis. Consequently, M. bovis infected buffaloes pose a transmission risk for cattle and other wildlife species. Previously, a modification to the Qiagen QuantiFERON® -TB Gold (QFT) system, using QFT tubes and an in-house bovine interferon-gamma (IFN-γ) ELISA, was evaluated for the detection of M. bovis infection in buffaloes. Subsequently, Qiagen has developed a commercially available cattletype® IFN-gamma ELISA for the detection of antigen-specific IFN-γ release in ruminants...
February 2018: Veterinary Immunology and Immunopathology
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