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https://www.readbyqxmd.com/read/28633591/approaches-in-topical-ocular-drug-delivery-and-developments-in-the-use-of-contact-lenses-as-drug-delivery-devices
#1
Prina Mehta, Rita Haj-Ahmad, Ali Al-Kinani, Muhammad Sohail Arshad, Ming-Wei Chang, Raid G Alany, Zeeshan Ahmad
Drug-delivery approaches have diversified over the last two decades with the emergence of nanotechnologies, smart polymeric systems and multimodal functionalities. The intended target for specific treatment of disease is the key defining developing parameter. One such area which has undergone significant advancements relates to ocular delivery. This has been expedited by the development of material advancement, mechanistic concepts and through the deployment of advanced process technologies. This review will focus on the developments within lens-based drug delivery while touching on conventional and current methods of topical ocular drug delivery...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28629902/relationship-between-vessel-diameter-and-depth-measurements-within-the-limbus-using-ultra-high-resolution-optical-coherence-tomography
#2
Emmanuel Alabi, Natalie Hutchings, Kostadinka Bizheva, Trefford Simpson
PURPOSE: To establish a relationship between the diameter and depth position of vessels in the superior and inferior corneo-scleral limbus using ultra-high resolution optical coherence tomography (UHR-OCT). METHODS: Volumetric OCT images of the superior and inferior limbus were acquired from 14 healthy subjects with a research-grade UHR-OCT system. Differences in vessel diameter and depth between superior and inferior limbus were analyzed using repeated measured ANOVA in SPSS and R...
June 16, 2017: Journal of Optometry
https://www.readbyqxmd.com/read/28627456/effect-of-the-surface-layer-on-drug-release-from-delefilcon-a-dailies-total1-%C3%A2-contact-lenses
#3
Phillip Dixon, Anuj Chauhan
Contact lenses are receiving significant attention for delivering ophthalmic drugs with higher bioavailability compared to eye drops. Here we explore drug transport from delefilcon-A Dailies Total1(®) lenses which are designed to have a thin, high-water content layer on the surface. Our goal is to determine the impact of this high water content layer on drug transport for both hydrophobic (dexamethasone and cyclosporine) and hydrophilic (timolol and levofloxacin) drugs. Drugs were loaded into the lens by soaking in aqueous drug solutions till equilibrium, followed by release in phosphate buffered saline...
June 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28625688/electrically-atomised-formulations-of-timolol-maleate-for-direct-and-on-demand-ocular-lens-coatings
#4
Prina Mehta, Ali Al-Kinani, Rita Haj-Ahmad, Muhammad Sohail Arshad, Ming-Wei Chang, G Raid Alany, Zeeshan Ahmad
Advances in nanotechnology have enabled solutions for challenging drug delivery targets. While the eye presents numerous emerging opportunities for delivery, analysis and sensing; issues persist for conventional applications. This includes liquid phase formulation localisation on the ocular surface once administered as formulated eye-drops; with the vast majority of dosage (>90%) escaping from the administered site due to tear production and various drainage mechanisms. The work presented here demonstrates a single needle electrohydrodynamic (EHD) engineering process to nano-coat (as an on demand and controllable fiber depositing method) the surface of multiple contact lenses rendering formulations to be stationary on the lens and at the bio-interface...
June 15, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28624312/non-lens-based-surgical-techniques-for-presbyopia-correction
#5
R Bilbao-Calabuig, F Llovet-Osuna
INTRODUCTION: Presbyopia is the most prevalent refractive error. With a progressive aging population, its surgical correction is an important challenge for the ophthalmology community, as well as the millions of patients who suffer from it, and who are increasingly demanding alternatives to its correction with glasses or contact lenses. MATERIAL AND METHODS: A review is presented with a synthesised discussion on the pathophysiological theories of presbyopia and an updated and analytical description of the non-lens involvement surgical techniques used to treat presbyopia...
June 14, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28623041/-corneal-dystrophies
#6
REVIEW
J-L Bourges
Degenerative or hereditary corneal diseases are sometimes difficult to discriminate. Corneal dystrophies affect approximately 0.09 % of the population. They are identified by the IC3D classification based on their phenotype, genotype and evidence gathered for their diagnosis. Practically, the ophthalmologist manages functional symptoms, such as recurrent erosions, visual loss and amblyopia, photophobia, foreign body sensation, and sometimes pain and aesthetic concerns. Medical treatments consist of drops to promote healing, ointments, hyperosmotic agents and bandage contact lenses...
June 13, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28619486/extended-depth-of-focus-contact-lenses-vs-two-commercial-multifocals-part-2-visual-performance-after-1-week-of-lens-wear
#7
Ravi C Bakaraju, Daniel Tilia, Jennifer Sha, Jennie Diec, Jiyoon Chung, Danny Kho, Shona Delaney, Anna Munro, Varghese Thomas
PURPOSE: To compare the visual performance of prototype contact lenses designed via deliberate manipulation of higher-order spherical aberrations to extend-depth-of-focus with two commercial multifocals, after 1 week of lens wear. METHODS: In a prospective, participant-masked, cross-over, randomized, 1-week dispensing clinical-trial, 43 presbyopes [age: 42-63 years] each wore AIROPTIX Aqua multifocal (AOMF), ACUVUE OASYS for presbyopia (AOP) and extended-depth-of-focus prototypes (EDOF) appropriate to their add requirements...
June 12, 2017: Journal of Optometry
https://www.readbyqxmd.com/read/28617731/retention-rates-in-new-contact-lens-wearers
#8
Anna Sulley, Graeme Young, Chris Hunt, Sarah McCready, Marie-Therese Targett, Ruth Craven
PURPOSE: To determine the retention rate (RR) for neophyte patients fitted with contact lenses (CLs) and to identify factors associated with retention and dropout. METHOD: This multisite, sponsor-masked registry study evaluated the 1-year status of neophyte CL wearers fitted in a representative range of UK practices. A total of 26 UK investigational sites each recruited up to 89 neophyte patients. The participants were requested to complete surveys at 1 month (±1 week from date of fitting), 3 months (±2 weeks), and 12 months (±3 weeks) online or through phone...
June 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28617726/comparative-analysis-of-peripheral-corneal-geometry-in-health-and-keratoconus
#9
Enric Mas-Aixala, Joan Gispets, Núria Lupón, Genís Cardona
OBJECTIVES: To describe and compare corneal peripheral angles in normal and keratoconic eyes, to gain a better understanding of the topography of the periphery of the cornea in keratoconus and assist practitioners in the selection and fitting of large diameter contact lenses. METHODS: Eighty-eight eyes were included in the study, divided into three groups: healthy (A0, 28 eyes), keratoconus at stage I according to the Amsler-Krumeich classification (AI, 33 eyes) and keratoconus at stages II to IV (AII, 27 eyes)...
June 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28617725/depth-profile-assessment-of-the-early-phase-deposition-of-lysozyme-on-soft-contact-lens-materials-using-a-novel-in-vitro-eye-model
#10
Han Qiao, Chau-Minh Phan, Hendrik Walther, Lakshman N Subbaraman, Lyndon Jones
OBJECTIVE: To characterize the location of fluorescently labeled lysozyme on commercial contact lenses (CLs) using an in vitro eye model that simulates tear volume, tear flow, air exposure, and mechanical wear. METHODS: One commercially available conventional hydrogel CL material (etafilcon A) and three silicone hydrogel CL materials (balafilcon A, lotrafilcon B, and senofilcon A) were evaluated in this study. The CLs were mounted on the in vitro eye model and exposed to artificial tear fluid containing fluorescein isothiocyanate (FITC)-labeled lysozyme for 2 and 10 hrs...
June 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28617724/intracorneal-inlays-for-the-correction-of-presbyopia
#11
Perry S Binder
The current nonsurgical approaches for the correction of presbyopia are spectacles or contact lenses or the use of pharmaceuticals to create an artificial pupil and/or to stimulate residual accommodation. Refractive surgical procedures use a monovision approach and/or a multifocal corneal laser ablation with or without the induction of negative spherical aberration to improve near vision. More recently, new surgical approaches include intracorneal inlays. Inlay approaches include increasing corneal curvature alone, implanting a multifocal inlay, or by implanting a small aperture device that functions as a pinhole to restore unaided near and intermediate visual acuity...
June 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28606456/extended-depth-of-focus-contact-lenses-vs-two-commercial-multifocals-part-1-optical-performance-evaluation-via-computed-through-focus-retinal-image-quality-metrics
#12
Ravi C Bakaraju, Klaus Ehrmann, Arthur Ho
PURPOSE: To compare the computed optical performance of prototype lenses designed using deliberate manipulation of higher-order spherical aberrations to extend depth-of-focus (EDOF) with two commercial multifocals. METHODS: Emmetropic, presbyopic, schematic eyes were coupled with prototype EDOF and commercial multifocal lenses (Acuvue Oasys for presbyopia, AOP, Johnson & Johnson & Air Optix Aqua multifocal, AOMF, Alcon). For each test configuration, the through-focus retinal image quality (TFRIQ) values were computed over 21 vergences, ranging from -0...
June 9, 2017: Journal of Optometry
https://www.readbyqxmd.com/read/28602948/emerging-strategies-for-antimicrobial-drug-delivery-to-the-ocular-surface-implications-for-infectious-keratitis
#13
REVIEW
Ajay Sharma, Jonathan Taniguchi
Infectious keratitis is a medical emergency that can cause severe visual morbidity if not treated promptly. Depending upon the causative microorganism, effective management of infectious keratitis requires frequent application of antibacterial, antifungal, or antiviral eye drops, which may have low bioavailability, undesirable side effects, and poor patient compliance. Ocular formulations of antimicrobials that can increase corneal permeation and provide extended presence on ocular surface are being developed...
June 7, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28589448/-laser-in-situ-keratomileusis-with-microkeratome-or-femtosecond-laser
#14
REVIEW
T Kohnen, G Steinwender
OBJECTIVE AND PRINCIPLES: In LASIK, after cutting a lamellating stromal corneal incision (flap) with a microkeratome or a femtosecond laser, the underlying tissue is treated with an excimer laser for refractive correction. The objective is to achieve independency from spectacles and contact lenses due to correction of ametropia. INDICATIONS: Surgery is indicated when the patient wishes to achieve independency from spectacles and contact lenses. For LASIK, the German Commission for Refractive Surgery defined a range of applicability for myopic correction up to -8 diopters (D), astigmatic correction up to 5 D and hyperopic correction up to +3 D...
June 6, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28586914/visual-performance-and-optical-quality-of-standardized-asymmetric-soft-contact-lenses-in-patients-with-keratoconus
#15
Asaki Suzaki, Naoyuki Maeda, Mutsumi Fuchihata, Shizuka Koh, Kohji Nishida, Takashi Fujikado
Purpose: To evaluate the visual performance and optical quality of a standardized asymmetric soft contact lens (SCL) used for correction of higher-order aberrations (HOAs) in eyes with keratoconus. Methods: We included 30 eyes (26 patients) with keratoconus (average K: 45.7 ± 2.3 diopters [D]). The patients were subjected to corneal tomography, aberrometry, measurements of manifest refraction and visual acuity (VA), and visual analog scale (VAS) assessments. The study lenses were made using a molding method and consisted of six standardized types, in which an asymmetric power distribution of approximately 2 to 12 D (2-D step) was used to correct HOAs...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28583694/corneal-dystrophies
#16
J-L Bourges
Degenerative or hereditary corneal diseases are sometimes difficult to discriminate. Corneal dystrophies affect approximately 0.09% of the population. They are identified by the IC3D classification based on their phenotype, genotype and evidence gathered for their diagnosis. In practice, the ophthalmologist manages functional symptoms such as recurrent erosions, visual loss and amblyopia, photophobia, foreign body sensation, and sometimes pain and aesthetic concerns. Medical treatments consist of drops to promote healing, ointments, hyperosmotic agents and bandage contact lenses...
June 2, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28582374/management-of-corneal-scarring-secondary-to-herpes-zoster-keratitis
#17
Omar M Hassan, Asim V Farooq, Ketki Soin, Ali R Djalilian, Joshua H Hou
PURPOSE: To review the management of visually significant corneal scarring secondary to herpes zoster keratitis (HZK). METHODS: Literature review. RESULTS: Management options for visually significant corneal scarring secondary to HZK include scleral contact lenses, photorefractive or phototherapeutic keratectomy, lamellar keratoplasty, penetrating keratoplasty, and keratoprosthesis. Many authors recommend tarsorrhaphy in at-risk patients at the time of corneal transplantation...
June 2, 2017: Cornea
https://www.readbyqxmd.com/read/28577503/ph-triggered-controlled-drug-delivery-from-contact-lenses-addressing-the-challenges-of-drug-leaching-during-sterilization-and-storage
#18
Furqan A Maulvi, Harsh H Choksi, Ankita R Desai, Akanksha S Patel, Ketan M Ranch, Bhavin A Vyas, Dinesh O Shah
In the present work a novel cyclosporine-loaded Eudragit S100 (pH-sensitive) nanoparticles-laden contact lenses were designed to provide sustained release of cyclosporine at therapeutic rates, without leaching of drug during sterilization and storage period (shelf life). The nanoparticles were prepared by Quasi-emulsion solvent diffusion technique using different weight ratios of cyclosporine to Eudragit S100. The contact lenses with direct drug entrapment were also fabricated (DL-50) for comparison. The percentage swelling and optical transparency of nanoparticles-laden contact lenses were improved in comparison to DL-50 lenses...
May 27, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28575999/sterilization-of-silicone-based-hydrogels-for-biomedical-application-using-ozone-gas-comparison-with-conventional-techniques
#19
Raquel Galante, Daniela Ghisleni, Patrizia Paradiso, Vitor D Alves, Terezinha J A Pinto, Rogério Colaço, Ana Paula Serro
Sterilization of hydrogels is challenging due to their often reported sensitivity to conventional methods involving heat or radiation. Although aseptic manufacturing is a possibility, terminal sterilization is safer in biological terms, leading to a higher overall efficiency, and thus should be used whenever it is possible. The main goal of this work was to study the applicability of an innovative ozone gas terminal sterilization method for silicone-based hydrogels and compare its efficacy and effects with those of traditional sterilization methods: steam heat and gamma irradiation...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28560848/advanced-silicon-chemistry-in-australia-forming-strong-links-with-asia
#20
Stephen Clarke, Kim-Anh Thi Nguyen, Elda Markovic, Neil Trout, Milena Ginic-Markovic, Janis Matisons, Michael Owen, Daniel Graiver, Agus Hadi Santosa Wargadipura, Sudirman Habibie, Dwi Gustiono, Bok Ryul Yoo, Joe Mifsud
This paper details Australian commercial and academic silicon research. Areas of interest include silicon metal, polysiloxane polymers, copolymers, cyclics, emulsions, microemulsions, silanes, silane coupling agents, sol-gel chemistry and water-treatments, porous silicon, polysiloxane degradation, silicon hydrogel contact lenses, silanolate synthesis, siloxane interfacial polymerisation, hydrosilylation, polysiloxane electrolytes for lithium ion batteries, silanes for PBX materials, octafunctionalized polyhedral oligomeric silsesquioxanes (POSS), POSS hybrids, sol-gel hydrogenation catalysts, silane modification of silica, sol-gel energy storage, silicate grout stabilisation, GeoPolymer concretes, aerogel insulating foams, "Phaco-Ersatz" Accommodating Gel-Intraocular Lens technologies...
June 1, 2017: Chemistry, An Asian Journal
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