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https://www.readbyqxmd.com/read/27918833/effects-of-lead-phytochemicals-of-radix-scutellariae-on-acanthamoeba
#1
Pauline Cho, Guangsen Shi, Maurice Yap, Maureen V Boost
Purpose: Acanthamoeba keratitis (AK), which is associated with noncompliant use of contact lenses, remains difficult to treat due to delayed diagnosis and paucity of therapeutic agents. Although improvements in activity against Acanthamoeba infection have been achieved in disinfecting solutions for soft contact lenses, such modifications have not been extended to those for special rigid gas permeable (RGP) contact lenses, which are increasingly used for myopia control in children. Phytochemicals present in herbs used for traditional Chinese medicine may be effective as therapeutic or preventive agents...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27914235/hyaluronan-as-a-promising-excipient-for-ocular-drug-delivery
#2
REVIEW
Michaela Guter, Miriam Breunig
Hyaluronan (HA) is a naturally occurring polysaccharide and well known for its exceptional properties such as high biocompatibility and biodegradability, along with a low immunogenicity. Besides its use for various biomedical applications it recently came into focus as a favorable excipient for the formulation of various ocular therapeutics. This review article summarizes the ocular distribution of HA and its most heavily investigated binding protein "cluster of differentiation 44" (CD44) which is the rationale for the clinical use of HA, primarily as an additive in ocular applications ranging from eye drops to contact lenses...
November 30, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27911424/-effectiveness-of-soft-contact-lenses-in-severe-keratoconjunctivitis-sicca-treated-with-local-immunosuppressive-therapy
#3
T N Safonova, O V Gladkova, V I Boev, A A Fedorov
AIM: To study the effectiveness of soft contact lenses in severe keratoconjunctivitis sicca (KCS) treated with local immunosuppressive therapy. MATERIAL AND METHODS: We have examined 41 patients (60 eyes) with severe KCS, including 3 men (4 eyes) and 38 women (56 eyes) aged from 27 to 76 years. Group 1 consisted of 22 persons (30 eyes) who were prescribed cyclosporine А 0.05% instillations 2 times daily, artificial tears, and soft contact lenses. Group 2 consisted of 19 patients (30 eyes) who received instillations of cyclosporine А 0...
2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27908604/compatibility-of-phospholipid-liposomal-spray-with-silicone-hydrogel-contact-lens-wear
#4
Michael T M Wang, Kalaivarny Ganesalingam, Chee Seang Loh, Trisha Alberquerque, Suhaila Al-Kanani, Stuti L Misra, Jennifer P Craig
PURPOSE: To assess the effects of two weeks of regular phospholipid liposomal spray application on lipid layer grade, tear film stability, subjective comfort, visual acuity, and lipid deposition in silicone hydrogel contact lens wearers. METHODS: Thirty-one existing contact lens wearers were enrolled and fitted with two week planned replacement silicone hydrogel contact lenses (Acuvue(®) Oasys(®)) in a prospective, randomized, paired-eye, investigator-masked trial...
November 28, 2016: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/27900926/-corneal-cross-linking-as-a-treatment-for-progressive-keratoconus
#5
R P L Wisse, N Soeters, D A Godefrooij, N G de Koning-Tahzib
Keratoconus is a corneal disease with onset typically occurring during puberty or early adulthood. The cornea progressively thins and acquires a cone-like shape which negatively affects visual acuity. In the early stages, visual acuity can be corrected with glasses or contact lenses. In more advanced cases, a corneal transplant is ultimately indicated to restore visual acuity. Corneal cross-linking (CXL) is a treatment given at a relatively early stage that protects patients against deterioration of visual acuity and further corneal deformation in progressive cases of keratoconus...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27898516/clinical-evaluation-of-large-diameter-rigid-gas-permeable-versus-soft-toric-contact-lenses-for-the-correction-of-refractive-astigmatism-a-multicenter-study
#6
Langis Michaud, Edward S Bennett, Stephanie L Woo, Renee Reeder, Bruce W Morgan, Amy Dinardo, Jennifer S Harthan
PURPOSE: This study aims to address the clinical performance of a large diameter rigid gas permeable lens (LRGP) in a group of subjects with low-to-moderate (0.75-2.75 D) refractive astigmatism. An additional goal was to determine whether soft toric or LRGP contact lenses performed better objectively in the correction of astigmatism and to determine which modality is preferred by subjects. METHODS: This was a multisite prospective cross-over clinical study. Ten asymptomatic contact lens wearers per site (four university clinics) were recruited and randomly assigned to group A or group B...
November 24, 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27898448/laser-vision-correction-in-treating-myopia
#7
Germano Leal Ehlke, Ronald R Krueger
Myopia is a generally benign refractive error with an increasing prevalence worldwide. It can be corrected temporarily with glasses and contact lenses and permanently with laser vision correction. The 2 main procedures currently being performed for myopia correction are photorefractive keratectomy and laser-assisted in situ keratomileusis. Each technique has its advantages, but they appear to yield similar visual outcomes 1 year after surgery. Laser vision correction for myopia was considered a paradigm shift because healthy eyes could now undergo a surgical procedure to permanently and safely correct the error by altering the center of the cornea, which was previously off limits because of the potential for loss of transparency...
November 2016: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/27897119/glaucoma-hot-topics-in-pharmacology
#8
Shiama I Balendra, Parth Arvind Shah, Mishank Jain, Andrzej Grzybowski, Francesca M Cordeiro
BACKGROUND: Glaucoma comprises a group of neurodegenerative diseases resulting in retinal ganglion cell death within the optic nerve head. It is projected to affect almost 80 million people worldwide by 2020. The condition's asymptomatic nature translates to over half of glaucoma sufferers being unaware of their condition. By the time of diagnosis, irreversible blindness is likely to have occurred. Prime areas of glaucoma research therefore include identification and optimization of risk factors for the disease, accurate and early diagnostic tools and novel therapeutic methods...
November 29, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27895981/perceived-image-quality-with-simulated-segmented-bifocal-corrections
#9
Carlos Dorronsoro, Aiswaryah Radhakrishnan, Pablo de Gracia, Lucie Sawides, Susana Marcos
Bifocal contact or intraocular lenses use the principle of simultaneous vision to correct for presbyopia. A modified two-channel simultaneous vision simulator provided with an amplitude transmission spatial light modulator was used to optically simulate 14 segmented bifocal patterns (+ 3 diopters addition) with different far/near pupillary distributions of equal energy. Five subjects with paralyzed accommodation evaluated image quality and subjective preference through the segmented bifocal corrections. There are strong and systematic perceptual differences across the patterns, subjects and observation distances: 48% of the conditions evaluated were significantly preferred or rejected...
November 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27884616/mechanical-properties-of-contact-lenses-the-contribution-of-measurement-techniques-and-clinical-feedback-to-50-years-of-materials-development
#10
REVIEW
Tarnveer Singh Bhamra, Brian J Tighe
PURPOSE: This review summarises the way in which mechanical property measurements combined with clinical perception have influenced the last half century of materials evolution in contact lens development. METHODS: Literature concerning the use of in-vitro testing in assessment of the mechanical behaviour of contact lenses, and the mutual deformation of the lens material and ocular tissue was examined. Tensile measurements of historic and available hydrogel lenses have been collected, in addition to manufacturer-generated figures for the moduli of commercial silicone hydrogel lenses...
November 21, 2016: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/27880992/studies-using-concentric-ring-bifocal-and-peripheral-add-multifocal-contact-lenses-to-slow-myopia-progression-in-school-aged-children-a-meta-analysis
#11
Shi-Ming Li, Meng-Tian Kang, Shan-Shan Wu, Bo Meng, Yun-Yun Sun, Shi-Fei Wei, Luoru Liu, Xiaoxia Peng, Zhuo Chen, Fengju Zhang, Ningli Wang
PURPOSE: To evaluate the effect of soft contact lens with concentric ring bifocal and peripheral add multifocal designs on controlling myopia progression in school-aged children. METHODS: We systematically searched MEDLINE, EMBASE, Cochrane Library and reference lists of included trials. Methodological quality of included trials was assessed using Jadad Scale and Newcastle-Ottawa Quality Assessment Scale items. RESULTS: We identified five randomised controlled trials (RCTs) and three cohort studies with a total of 587 myopic children...
November 23, 2016: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/27879499/impact-of-spherical-aberration-terms-on-multifocal-contact-lens-performance
#12
Cathleen Fedtke, Jennifer Sha, Varghese Thomas, Klaus Ehrmann, Ravi C Bakaraju
PURPOSE: To investigate the impact of the primary (PSA) and secondary (SSA) spherical aberration terms on visual performance (VP) in presbyopes, as measured using multifocal (MFCL) soft contact lenses on eye. METHODS: Seventeen presbyopes (age: 55.1 ± 6.9 years) wore seven commercial lenses (four center-near (MFCL N), one center-distance (MFCL D), one bifocal, and one single vision control). Unaided and with each lens on eye, the PSA and SSA terms were obtained with an aberrometer, the BHVI-EyeMapper (low illumination, natural and 4 mm pupil diameter)...
November 22, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27876528/the-impact-of-lens-care-solutions-on-corneal-epithelial-changes-during-daily-silicone-hydrogel-contact-lens-wear-as-measured-by-in-vivo-confocal-microscopy
#13
Xiaolin Zhang, Christine Marchetti, Jessica Lee, Yan Sun, Sara Debanne, Ying Jiang, Jami Kern, Mark Harrod, Beth Ann Benetz, Eric Pearlman, Loretta Szczotka-Flynn
PURPOSE: To assess corneal epithelial microstructure via confocal microscopy and determine if cellular changes are associated with lens care solutions during daily wear of silicone hydrogel contact lenses. METHODS: Corneal in vivo confocal microscopy with the Nidek ConfoScan4 was performed at baseline and after 5 months of lotrafilcon A daily contact lens wear. Enrolled participants were randomized to use either a polyhexamethylene biguanide (PHMB) preserved multipurpose care solution (MPS) or a peroxide based solution system...
November 19, 2016: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/27874294/dacryoadenitis-and-extraocular-muscle-inflammation-associated-with-contact-lens-related-acanthamoeba-keratitis-a-case-report-and-review-of-the-literature
#14
Tomris Sengor, Erdal Yuzbasioglu, Sevda Aydın Kurna, Murat Irkec, Ahmet Altun, Kubra Kökcen, Nazli Gul Yalcin
The present report discusses a new case of dacryoadenitis with extraocular muscle inflammation associated with Acanthamoeba keratitis (AK) in a contact lens wearer. A 41-year-old male, who has worn silicone hydrogel contact lenses on an extended basis for about 10 years, attended with the complaints of vision disturbance, hyperemia, and pain in his right eye. His history revealed that 1.5 month ago, he had been diagnosed with allergic conjunctivitis and had used steroid eye drops. Biomicroscopic examination revealed eyelid edema, chemosis, and ring infiltration, radial keratoneuritis and an epithelial defect in the cornea...
November 22, 2016: Orbit
https://www.readbyqxmd.com/read/27864795/prevalence-of-ocular-surface-disease-symptoms-and-risk-factors-in-group-of-university-students-in-monterrey-mexico
#15
Manuel Garza-León, Miguel Valencia-Garza, Bernardo Martínez-Leal, Pablo Villarreal-Peña, Hernán Gerardo Marcos-Abdala, Ana Lucía Cortéz-Guajardo, Arturo Jasso-Banda
BACKGROUND: The objective of this study was to determine the prevalence of symptoms of ocular surface disease and its relationship with associated risk factors in students from the University of Monterrey using Ocular Surface Disease (OSDI) questionnaire. METHODS: A cross-sectional survey was conducted between October and December 2014 to assess the prevalence and risk factors for ocular surface disease in a group of students from Universidad de Monterrey in Monterrey, Mexico...
December 2016: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/27861262/tear-film-osmolarity-in-response-to-long-term-orthokeratology-treatment
#16
Amelia Nieto-Bona, María Nombela-Palomo, Gema Felipe-Márquez, Miguel A Teus
PURPOSE: To compare tear film osmolarity (TFO) measurements in non-contact lens (CL) wearers and wearers of hydrogel or overnight orthokeratology (OK) CLs, and to assess possible effects of long-term OK on TFO. METHODS: Overall, 108 subjects with moderate myopia participated in 2 experiments, and TFO was measured using the TearLab osmolarity system. In experiment 1, TFO measurements were made in 77 right eyes of 23 non-CL wearers, 26 hydrogel wearers, and 28 OK wearers...
November 16, 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27847690/release-of-moxifloxacin-from-contact-lenses-using-an-in-vitro-eye-model-impact-of-artificial-tear-fluid-composition-and-mechanical-rubbing
#17
Chau-Minh Phan, Magdalena Bajgrowicz-Cieslak, Lakshman N Subbaraman, Lyndon Jones
PURPOSE: The aim of this study was to evaluate and compare the release of moxifloxacin from a variety of daily disposable (DD) contact lenses (CLs) under various conditions using a novel in vitro eye model. METHODS: Four commercially available DD conventional hydrogel (CH) CLs (nelfilcon A, omafilcon A, etafilcon A, and ocufilcon B) and three silicone hydrogel (SH) CLs (somofilcon A, narafilcon A, and delefilcon A) were evaluated. These lenses were incubated in moxifloxacin for 24 hours...
November 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27830209/tear-deformation-time-and-optical-quality-in-eyes-wearing-silicone-hydrogel-contact-lenses
#18
Amir Asharlous, Ebrahim Jafarzadehpur, Ali Mirzajani, Mehdi Khabazkhoob, Samira Heydarian, Ali Taghipour
PURPOSE: To evaluate tear film stability and optical aberrations in eyes wearing plano Lotrafilcon B contact lenses (CL). METHODS: Tear Deformation Time (TDT) and aberrometric parameters were assessed in 86 normal emmetropic eyes before and 6 h after wearing CL. RESULT: A statistically significant decrease in TDT and increase in root mean square (RMS) values of higher order aberrations (HOA) were revealed 6 h after CL insertion (both P < 0...
December 2016: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/27830203/corneal-aberration-changes-after-rigid-gas-permeable-contact-lens-wear-in-keratokonic-patients
#19
Fereshteh Shokrollahzadeh, Hassan Hashemi, Ebrahim Jafarzadehpur, Ali Mirzajani, Mehdi Khabazkhoob, Abbasali Yekta, Soheila Asgari
PURPOSE: To determine the short-term effect of rigid gas permeable (RGP) contact lenses on corneal aberrations in keratoconic patients. METHOD: Sixteen keratoconic eyes with no history of RGP lens wear were included. They all had corneal aberrometry using Pentacam, and different aberration indices of the anterior and posterior surfaces of the cornea were measured before and 3 months after fitting RGP lenses. The effect of baseline parameters on these changes was tested in univariate and multiple models...
December 2016: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/27822628/-toric-add-on-intraocular-lenses-for-correction-of-high-astigmatism-after-pseudophakic-keratoplasty
#20
A Hassenstein, F Niemeck, K Giannakakis, M Klemm
Perforating keratoplasty shows good morphological results with a clear cornea; however, a limiting factor is often the resulting astigmatism, which cannot be corrected with either glasses or contact lenses (CL) in up to 20% of the patients. We retrospectively investigated 15 patients after pseudophakic perforating keratoplasty, who received implantation of toric add-on intraocular lenses (IOL) to correct astigmatism. The mean preoperative astigmatism of 6.5 diopter (dpt) could be reduced to a mean postoperative value of 1...
November 7, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
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