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Recurrent implantation failure

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https://www.readbyqxmd.com/read/28904504/role-of-serpine-gene-polymorphism-in-recurrent-implantation-failure-and-preeclampsia
#1
Nidhi Sharma, Jayashree K Srinivasan, Margeret Harriet Priya, Venkatachalam Sibiya
This is a rare case of serpine gene polymorphism causing thrombophilia and recurrent implantation failure following intrauterine insemination. SERPINE1 gene encodes plasminogen activator inhibitor type 1 and inhibits fibrinolysis, or clot dissolution. The 4G variant results in increased expression of SERPINE1 and consequently higher inhibition of fibrinolysis, thus leading to thrombophilia. The patient had unexplained primary infertility for 9 years. Ovulation induction was done with gonadotropin releasing hormone (GnRH) agonist long protocol...
April 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/28887273/use-of-the-dual-construct-for-the-management-of-complex-spinal-reconstructions
#2
Francis H Shen, Rabia Qureshi, Rose Tyger, Rebecca Lehman, Anuj Singla, Adam Shimer, Hamid Hassanzadeh
BACKGROUND CONTEXT: Surgical management of complex spinal reconstructions remains a clinical challenge, as pseudoarthrosis with subsequent rod breakage can occur. Increased rod density in the form of "satellite" or "outrigger" rods have been described; however rod-fracture above or below satellite rods persist and can result in dissociation of the construct, loss of correction, and recurrence of deformity. The use of four distinct and mechanically independent rods (Dual Construct) reduces this concern...
September 5, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28863411/sirtuin-1-levels-in-recurrent-implantation-failure
#3
Yaprak Engin-Ustun, A Seval Ozgu-Erdinc, Emel Kiyak Caglayan, Cavidan Gulerman, Esma Sarikaya, Ayla Aktulay, Canan Demirtas, Salim Erkaya, Nafiye Yilmaz
Sirtuin 1 has an important role in cellular processes, including apoptosis and cellular stress. The purpose of this study was to assess serum sirtuin 1 levels in women with recurrent implantation failure (RIF). In this cross-sectional study, we included 28 women with RIF, 29 healthy women who had conceived by in vitro fertilization (IVF), and 30 women with a 1-cycle failure of IVF as controls. Human serum nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin-1 (SIRT1/SIRT2L1) levels were detected using a commercial colorimetric kit...
September 1, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28860684/experience-of-the-posterior-lip-augmentation-device-in-a-regional-hip-arthroplasty-unit-as-a-treatment-for-recurrent-dislocation
#4
L Hoggett, C Cross, T Helm
INTRODUCTION: Dislocation after total hip arthroplasty (THA) remains a significant complication of the procedure and is the third leading cause for revision THA. One technique for treatment of this complication is the use of the posterior lip augmentation device (PLAD). We describe our experience using the PLAD including complication rates. METHODS: A retrospective review of 55 PLADs (54 patients) was carried out following identification from electronic theatre records...
December 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28858960/ahmed-valve-upstream-obstruction-caused-by-fibrous-ingrowth-surgical-approach
#5
Joana Medeiros Pinto, Nuno Pinto Ferreira, Luis Abegão Pinto
Glaucoma secondary to penetrating keratoplasty can be challenging and multiple surgeries may be needed to control the intraocular pressure (IOP), including the use of glaucoma drainage implants. However, late failure of these drainage implant surgery is common, mostly because of excessive scarring or bleb encapsulation which may require further surgical intervention. We present a case of a young patient referred for advanced glaucoma secondary to penetrating keratoplasty and chronic uveitis. He presented with elevated IOP under maximal therapy, already with 2 failed trabeculectomies and a nonfunctional Ahmed Valve...
August 30, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28844910/a-retrospective-study-of-thoracolumbar-fractures-treated-with-fixation-and-non-fusion-surgery-of-intra-vertebral-bone-graft-assisted-with-balloon-kyphoplasty
#6
Chengmin Zhang, Bin Ouyang, Pei Li, Liyuan Wang, Lei Luo, Chen Zhao, Liehua Liu, Bing Tu, Tianyong Hou, Paul Arnold, Qiang Zhou
BACKGROUND: Posterior fixation and fusion is the primary treatment for thoracolumbar fractures, although this treatment may sacrifice range of motion (ROM) to achieve stability, rather than treating the fracture itself. Two issues addressed when treating thoracolumbar fractures include 1) replacing the fractured vertebrae, especially the upper endplate of the injured vertebrae, and 2) providing strong fixation with biomechanical stability and flexibility. METHODS: This retrospective study included 61 consecutive patients with thoracic or lumbar fractures treated from October 2010 to May 2014...
August 24, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28843763/metastatic-basal-cell-adenocarcinoma-of-submandibular-gland-to-the-spine-an-extremely-rare-condition-a-case-report
#7
Tinnakorn Pluemvitayaporn, Sombat Kunakornsawat, Chaiwat Piyaskulkaew, Pritsanai Pruttikul, Warongporn Pongpinyopap
Basal cell adenocarcinomas (BCACs) are rare malignant neoplasms of salivary glands, accounting for less than 1% of salivary gland tumors. Few cases of distant metastases have been reported. To our knowledge, metastases to the spine have not been previously reported in the literature. We presented an unusual case of a 50-year-old Thai male, who was diagnosed as basal cell adenocarcinoma of submandibular gland with pulmonary and cervical spine metastases with progressive myelopathy, treated with wide surgical resection of the soft tissue tumor and modified radical neck dissection, anterior cervical total corpectomy with fusion combined with posterior decompression and fusion of the cervical spine and surgical wound coverage by anterolateral thigh free tissue transfer, followed by adjuvant radiotherapy...
August 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28838516/cardiac-regeneration-in-the-human-left-ventricle-after-cormatrix-implantation
#8
Alice Ferng, Alana Connell, Martha Nunez, Kitsie Johnson, Beth Braunhut, Scott Lick, Ankit Desai, Toshinobu Kazui, Ray Runyan, Zain Khalpey
CorMatrix is an organic extracellular matrix (ECM) derived from porcine small intestine submucosa and is used for pericardial closure and cardiac tissue repair. During explantation of a HeartMate II (Thoratec Corp, Pleasanton, CA) left ventricular assist device (LVAD) because of infection, CorMatrix was used to repair the left ventricular apex and aorta. Three months later, a HeartWare HVAD (HeartWare International, Inc, Framingham, MA) was implanted for recurrent heart failure. Excised apical CorMatrix samples showed cardiac tissue remodeling with viable cardiomyoblasts similar to native myocardium...
September 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28815854/expression-of-natural-cytotoxicity-receptors-and-cytokine-production-on-endometrial-natural-killer-cells-in-women-with-recurrent-pregnancy-loss-or-implantation-failure-and-the-expression-of-natural-cytotoxicity-receptors-on-peripheral-blood-natural-killer-cells
#9
Atsushi Fukui, Ayano Funamizu, Rie Fukuhara, Hiroaki Shibahara
AIM: Natural cytotoxicity receptors (NCR) are unique markers that regulate natural killer (NK) cell cytotoxicity and cytokine production. In this study, we investigated the expression of NCR (NKp46, NKp44, and NKp30) and cytokine production in NK cells derived from the uterine endometrium of women with recurrent pregnancy loss (RPL). We also investigated the expression of NCR in peripheral blood NK cells in pregnant women with and without a history of RPL. METHODS: The expression of NCR (NKp46, NKp44, and NKp30) in NK cells (CD56(dim) and CD56(bright) ) in the uterine endometrium was analyzed using 3-color flow cytometry...
August 17, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28807532/multicenter-evaluation-of-biochemical-relapse-free-survival-outcomes-for-intraoperatively-planned-prostate-brachytherapy-using-an-automated-delivery-system
#10
Kevin Martell, Siraj Husain, Daniel Taussky, Steve Angyalfi, Guila Delouya, Philippe Després, Luc Beaulieu, Andre-Guy Martin, Eric Vigneault
PURPOSE: To report biochemical recurrence in prostate cancer treated with intraoperatively planned low-dose-rate prostate brachytherapy using an automated delivery system (IO-LDRB). METHODS AND MATERIALS: Between 2003 and 2013, 2608 patients from 3 centers were treated with IO-LDRB as single-modality treatment for low or low-tier intermediate-risk prostate cancer. Databases from the 3 centers have been analyzed. These independent databases were collected prospectively...
June 6, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28807395/clinical-validation-of-pinopode-as-a-marker-of-endometrial-receptivity-a-randomized-controlled-trial
#11
Zhang Qiong, Hao Jie, Wang Yonggang, Xu Bin, Zhao Jing, Li Yanping
OBJECTIVE: To determine the clinical value of pinopodes in the human. DESIGN: Randomized controlled trial. SETTING: Academic fertility center. PATIENT(S): From December 2014 to December 2016, in a phase I trial, 363 patients were recruited in their first IVF cycles. In a phase II trial, 136 patients with at least two previous embryo implantation failures were recruited. INTERVENTION(S): In the phase I trial, in the midluteal phase, endometrial tissues were obtained for scanning electron microscopy, and their IVF treatment outcomes were followed up...
September 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28805198/severe-reversible-hypocalcemic-cardiomyopathy-diagnosed-36-years-after-subtotal-thyroidectomy-a-case-report
#12
Waldemar Elikowski, Małgorzata Małek-Elikowska, Patrycja Lachowska-Kotowska
Chronic hypocalcemia, irrespectively of its etiology, can lead to severe impairment of the left ventricular (LV) contractility manifesting as dilated cardiomyopathy, usually defined as hypocalcemic cardiomyopathy (hypocaCM). This rarely diagnosed type of heart failure (HF), can be completely reversible, when treated properly with calcium and vitamin D supplementation or, in some subjects, with human recombinant parathormone. A CASE REPORT: The authors present a case of a 60-year-old male admitted with advanced pulmonary congestion, recurrent pulmonary edema and pleural effusion...
July 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28777390/thrombosis-in-left-ventricular-assistance-device-with-centrifugal-technology-is-early-thrombolysis-a-better-solution
#13
Paolo Centofanti, Andrea Baronetto, Matteo Attisani, Davide Ricci, Erika Simonato, Michele W La Torre, Massimo Boffini, Mauro Rinaldi
BACKGROUND: Continuous flow left ventricular assistance devices (CF-LVADs) have revolutionized the treatment of advanced heart failure. Pump replacement for thrombosis is a high-risk procedure with a high perioperative mortality rate with possible recurrence. We aim to summarize our experience using a conservative approach with medical therapy. METHODS: We retrospectively reviewed records of patients who experienced pump thrombosis after LVAD implantation with HeartWare HVAD at our institution, from November 2010 to March 2016...
July 27, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28770293/case-series-of-patients-with-pathological-dyaphiseal-fractures-from-metastatic-bone-disease
#14
Dinu Vermesan, Radu Prejbeanu, Horia Haragus, Alis Dema, Manuel D Oprea, Diana Andrei, Dan V Poenaru, Marius Niculescu
INTRODUCTION: Fractures on pathologic bone have major impact on life quality. The appropriate treatment is not standardized, but the current literature delineates that surgery must provide adequate stabilization for the life expectancy. We aimed to review the epidemiology, treatment outcomes and survival in our department. MATERIAL AND METHODS: The electronic database from a major referral centre was searched for patients treated for tumours and fractures by the corresponding ICM-10 codes over five years...
August 2, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28758179/clinical-outcomes-of-posterior-c1-and-c2-screw-rod-fixation-for-atlantoaxial-instability
#15
Hasan Serdar Işik, Evren Sandal, Sedat Çağli
AIM: In this study, we aimed at sharing our experiences and contributing to the literature by making a retrospective analysis of the patients we operated with screw-rod system for atlantoaxial instability in our clinic. MATERIAL AND METHODS: Archive files of adult patients, who were operated for posterior C1-C2 stabilization with screw and rod in our clinic between January 2006 and January 2016, were analyzed. 28 patients, who had pre and post-operative images, follow-up forms and who were followed for at least one year, were analyzed...
June 14, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28743612/clinical-outcomes-after-interstitial-brachytherapy-for-early-stage-nasal-squamous-cell-carcinoma
#16
Warren Bacorro, Alexandre Escande, Stéphane Temam, Isabelle Dumas, Emilie Routier, Marie-Catherine Gensse, Pierre Blanchard, François Janot, Christine Mateus, Yungan Tao, Caroline Robert, Eric Deutsch, Christine Haie-Meder, Cyrus Chargari
PURPOSE: Radiotherapy of nasal carcinomas results in cure rates comparable to surgery, with anatomic preservation and good cosmesis. Brachytherapy (BT) overcomes difficulties with dosimetric coverage and affords a localized and highly conformal irradiation. We report our experience of BT for early-stage nasal squamous cell carcinomas (SCCs). METHODS AND MATERIALS: Clinical data, BT parameters, and outcome of consecutive patients treated by interstitial BT in our institute between December 1982 and April 2015 for a localized nasal SCC were examined...
July 22, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28721889/clinical-outcomes-of-large-brain-metastases-treated-with-neurosurgical-resection-and-intraoperative-cesium-131-brachytherapy-results-of-a-prospective-trial
#17
A Gabriella Wernicke, Cole B Hirschfeld, Andrew W Smith, Shoshana Taube, Menachem Z Yondorf, Bhupesh Parashar, Lucy Nedialkova, Fridon Kulidzhanov, Samuel Trichter, Albert Sabbas, Rohan Ramakrishna, Susan Pannullo, Theodore H Schwartz
PURPOSE: Studies on adjuvant stereotactic radiosurgery to the cavity of resected brain metastases have suggested that larger tumors (>2.0 cm) have greater rates of recurrence and radionecrosis (RN). The present study assessed the effect of permanent low-dose (131)Cs brachytherapy on local control and RN in patients treated for large brain metastases. METHODS AND MATERIALS: After institutional review board approval, 42 patients with 46 metastases ≥2.0 cm in preoperative diameter were accrued to a prospective trial from 2010 to 2015...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28707148/chemokine-c-c-motif-ligand-2-ccl2-and-oxidative-stress-markers-in-recurrent-pregnancy-loss-and-repeated-implantation-failure
#18
Müberra Namlı Kalem, Nilufer Akgun, Ziya Kalem, Batuhan Bakirarar, Tugrul Celik
PURPOSE: The main purpose of this study is to evaluate the inflammatory response and oxidative stress together in the cases of recurrent pregnancy loss (RPL) and repeated implantation failure (RIF). METHODS: This is a cross-sectional study conducted to compare infertile patients who have RIF and patients with RPL histories in terms of CCL2, TAS, TOS, and OSI. To this end, two study groups were formed by primary-infertile women with RIF history and women with nulliparous RPL history who consulted a university hospital between 2014 and 2016, and a control group was formed by multiparous women who had no pregnancy loss...
July 13, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28707147/the-hla-g-14-bp-polymorphism-and-recurrent-implantation-failure-a-meta-analysis
#19
REVIEW
Wei Fan, Zhongying Huang, Shangwei Li, Zhun Xiao
PURPOSE: The human leucocyte antigen-G (HLA-G) 14-bp insertion/deletion polymorphism was implicated in recurrent implantation failure (RIF), but individual published studies showed inconclusive results. Thus, a meta-analysis was performed to clarify the effect of HLA-G 14-bp polymorphism on RIF risk. METHODS: A comprehensive search for relevant articles was conducted. The odds ratios (ORs) and 95% confidence intervals (CIs) for HLA-G 14-bp polymorphism and RIF were calculated...
July 13, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28704242/long-term-clinical-outcome-after-implantation-of-the-self-expandable-stentys-stent-in-a-large-multicenter-cohort
#20
Luise Gaede, Christoph Liebetrau, Oliver Dörr, Johannes Blumenstein, Albrecht Elsässer, Christian W Hamm, Helge Möllmann, Christian Schlundt, Holger M Nef, Stephan Achenbach
OBJECTIVE: The objective of the study was to retrospectively evaluate the long-term clinical outcome after implantation of the self-expandable (SE) STENTYS stent in a large multicenter cohort. BACKGROUND: Incomplete stent apposition is known to cause higher rates of myocardial infarction (MI) and stent thrombosis. Because of its self-expanding features, the SE STENTYS stent adapts to the vessel wall and is therefore expected to minimize malapposition and therefore the rates of MI and stent thrombosis...
July 12, 2017: Coronary Artery Disease
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