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Recurrent implantation failure

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https://www.readbyqxmd.com/read/29759673/characterization-of-ventricular-tachycardia-after-left-ventricular-assist-device-implantation-as-destination-therapy-a-single-center-ablation-experience
#1
Joshua D Moss, Erin E Flatley, Andrew D Beaser, John H Shin, Hemal M Nayak, Gaurav A Upadhyay, Martin C Burke, Valluvan Jeevanandam, Nir Uriel, Roderick Tung
OBJECTIVES: This study sought to report mechanisms of ventricular tachycardia (VT) and outcomes of VT ablation in patients with a left ventricular assist device (LVAD) as destination therapy. BACKGROUND: Continuous flow LVAD implantation plays a growing role in the management of end-stage heart failure, and VT is common. There are limited reports of VT ablation in patients with a destination LVAD. METHODS: Patients with a continuous-flow LVAD referred for VT ablation from 2010 to 2016 were analyzed retrospectively...
December 11, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29752778/reactive-oral-lesions-associated-with-dental-implants-a-systematic-review
#2
REVIEW
Fazele Atarbashi-Moghadam, Saede Atarbashi-Moghadam, Mahshid Namdari, Shokoufeh Shahrabi-Farahani
Reactive lesion formation around dental implants a complication that has been given much consideration. These lesions can lead to marginal bone loss, and consequently, implant failure. In the present systematic review, all reported reactive lesions associated with dental implants in the literature were assessed. An electronic search was performed using PubMed Central, Scopus, Google Scholar, and Science Direct. The search strategy was limited to human studies (case reports and case series), full-text English language articles, published until May 2017...
May 11, 2018: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/29750365/effect-of-coronary-revascularization-on-long-term-clinical-outcomes-in-patients-with-ischemic-cardiomyopathy-and-recurrent-ventricular-arrhythmia
#3
Ihab Elsokkari, Ratika Parkash, Chris J Gray, Martin J Gardner, Amir M AbdelWahab, Steve Doucette, Anthony S Tang, George A Wells, William G Stevenson, John L Sapp
BACKGROUND: Patients with ventricular tachycardia (VT) post myocardial infarction (MI) are a higher risk group with significant morbidity and mortality. We examined the impact of prior coronary revascularization on clinical outcomes in patients with ischemic cardiomyopathy (ICM) and VT. METHODS: The VANISH trial randomized 259 patients with prior MI and antiarrhythmic drug-refractory VT to receive escalated medical therapy or catheter ablation. Clinical outcomes were compared according to whether patients have undergone prior revascularization procedures...
May 11, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29739285/association-between-mir-605a-g-mir-608g-c-mir-631i-d-mir-938c-t-and-mir-1302-3c-t-polymorphisms-and-risk-of-recurrent-implantation-failure
#4
Hyun Ah Lee, Eun Hee Ahn, Hyo Geun Jang, Jung Oh Kim, Ji Hyang Kim, Yu Bin Lee, Woo Sik Lee, Nam Keun Kim
Recurrent implantation failure (RIF) is diagnosed when pregnancy failure occurs after 2 consecutive in vitro fertilization-embryo transfers (IVF-ET) to the endometrium using at least 4 high-quality embryos. MicroRNAs (miRNAs) are a class of small noncoding RNA and reported to play an important role in cell proliferation as well as implantation process. Recently, it has been reported that miRNA can regulate RIF occurrence. So, we were to examine the association between the specific miRNA polymorphisms and RIF in Korean women...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29737471/does-the-endometrial-receptivity-array-really-provide-personalized-embryo-transfer
#5
Rawad Bassil, Robert Casper, Nivin Samara, Tzu-Bou Hsieh, Eran Barzilay, Raoul Orvieto, Jigal Haas
PURPOSE: The aim of the present study was to determine the percentage of infertility patients who are diagnosed with a non-receptive endometrium according to the endometrial receptivity array (ERA) test and to examine whether adjusting the embryo transfer day according to the proposed shift in the window of implantation improves the pregnancy rate compared to non-ERA-tested patients. METHODS: A single-center retrospective cohort study, including 53 consecutive good prognosis patients (0-2 previous frozen embryo transfers) admitted to our IVF unit for a mock cycle prior to their frozen day-5 embryo (blastocyst) transfer cycle...
May 8, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29733826/pulmonary-valve-replacement-a-single-institution-comparison-of-surgical-and-transcatheter-valves
#6
Vikas Sharma, Eric R Griffiths, Aaron W Eckhauser, Robert G Gray, Mary H Martin, Chong Zhang, Angela P Presson, Phillip T Burch
BACKGROUND: Transcatheter pulmonary valve replacement (TPVR) is increasingly utilized to address residual or recurrent right ventricular outflow tract pathology in congenital heart disease patients. We aimed to evaluate clinical outcomes and resource utilization comparing TPVR to surgical pulmonary valve replacement (SPVR) for this patient population. METHODS: From January 2010 until December 2015, 224 patients underwent pulmonary valve replacement (SPVR n=100 and TPVR n=124)...
May 4, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29726041/reoperation-for-composite-valve-graft-failure-operative-results-and-midterm-survival
#7
Luis C Maroto, Manuel Carnero, Javier Cobiella, Mónica García, Isidre Vilacosta, Fernando Reguillo, Enrique Villagrán, Carmen Olmos
BACKGROUND AND AIM OF THE STUDY: The replacement of a failed composite valve graft is technically more demanding and is associated with increased morbidity and mortality. We present our technique and outcomes for reoperations for composite graft failures. METHODS: Between September 2011 and June 2017, 14 patients underwent a redo composite graft replacement. Twelve patients (85.7%) were male, and mean age was 58.4 years ± 12 standard deviation (SD). One patient had two previous root replacements...
May 3, 2018: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29710196/long-term-outcomes-of-pediatric-onset-hypertrophic-cardiomyopathy-and-age-specific-risk-factors-for-lethal-arrhythmic-events
#8
Niccolò Maurizi, Silvia Passantino, Gaia Spaziani, Francesca Girolami, Anna Arretini, Mattia Targetti, Iva Pollini, Alessia Tomberli, Silvia Pradella, Giovanni Battista Calabri, Veronica Vinattieri, Bruno Bertaccini, Ornella Leone, Luciano De Simone, Claudio Rapezzi, Niccolò Marchionni, Franco Cecchi, Silvia Favilli, Iacopo Olivotto
Importance: Predictors of lethal arrhythmic events (LAEs) after a pediatric diagnosis of hypertrophic cardiomyopathy (HCM) are unresolved. Existing algorithms for risk stratification are limited to patients older than 16 years because of a lack of data on younger individuals. Objective: To describe the long-term outcome of pediatric-onset HCM and identify age-specific arrhythmic risk factors. Design, Setting, and Participants: This study assessed patients with pediatric-onset hypertrophic cardiomyopathy diagnosed from 1974 to 2016 in 2 national referral centers for cardiomyopathies in Florence, Italy...
April 18, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29699616/propranolol-versus-metoprolol-for-treatment-of-electrical-storm-in-patients-with-implantable-cardioverter-defibrillator
#9
Sofia Chatzidou, Christos Kontogiannis, Diamantis I Tsilimigras, Georgios Georgiopoulos, Marinos Kosmopoulos, Elektra Papadopoulou, Georgios Vasilopoulos, Stylianos Rokas
BACKGROUND: Electrical storm (ES), characterized by unrelenting recurrences of ventricular arrhythmias, is observed in approximately 30% of patients with implantable cardioverter-defibrillators (ICDs) and is associated with high mortality rates. OBJECTIVES: Sympathetic blockade with β-blockers, usually in combination with intravenous (IV) amiodarone, have proved highly effective in the suppression of ES. In this study, we compared the efficacy of a nonselective β-blocker (propranolol) versus a β1 -selective blocker (metoprolol) in the management of ES...
May 1, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29696170/international-electrical-storm-registry-electra-background-rationale-study-design-and-expected-results
#10
Federico Guerra, Michele Accogli, Paolo Bonelli, Corrado Carbucicchio, Valentina Catto, Laura Cipolletta, Gaetano Maria De Ferrari, Gabriele Dell'Era, Veronica Dusi, Oscar Fabregat-Andrés, Marco Flori, Eraldo Occhetta, Pietro Palmisano, Francesca Patani, Alessandro Proclemer, Alessandro Capucci
Electrical storm (ES) is defined as three or more episodes of ventricular fibrillation (VF) or ventricular tachycardia (VT) within 24 h and is associated with an increased cardiac and all-cause mortality. ES is a full arrhythmic emergency, its prevalence steadily increasing along with the number of implantable cardioverter-defibrillator implanted every year in developed countries. Nowadays, little evidence exists regarding clinical predictors of ES and their potential association on mortality and heart failure (HF), nor optimal pharmacological and non-pharmacological treatment has ever been codified...
September 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29692668/immune-modulation-of-i-v-immunoglobulin-in-women-with-reproductive-failure
#11
REVIEW
Ae R Han, Sung K Lee
Background: The mechanism of maternal immune tolerance of the semi-allogenic fetus has been explored extensively. The immune reaction to defend from invasion by pathogenic microorganisms should be maintained during pregnancy. An imbalance between the immune tolerance to the fetus and immune activation to the pathogenic organisms is associated with poor pregnancy outcomes. This emphasizes that the immune mechanism of successful reproduction is not just immune suppression, but adequate immune modulation...
April 2018: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29668899/how-uterine-microbiota-might-be-responsible-for-a-receptive-fertile-endometrium
#12
Marilen Benner, Gerben Ferwerda, Irma Joosten, Renate G van der Molen
BACKGROUND: Fertility depends on a receptive state of the endometrium, influenced by hormonal and anatomical adaptations, as well as the immune system. Local and systemic immunity is greatly influenced by microbiota. Recent discoveries of 16S rRNA in the endometrium and the ability to detect low-biomass microbiota fueled the notion that the uterus may be indeed a non-sterile compartment. To date, the concept of the 'sterile womb' focuses on in utero effects of microbiota on offspring and neonatal immunity...
April 16, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29667291/prevalence-of-hhv-6-in-endometrium-from-women-with-recurrent-implantation-failure
#13
Carolyn B Coulam, Mahmood Bilal, Maria D Salazar Garcia, Dimantha Katukurundage, Haidy Elazzamy, Emilio F Fernandez, Joanne Kwak-Kim, Kenneth Beaman, Svetlana V Dambaeva
PROBLEM: To study the prevalence of HHV-6 in endometrial biopsies among women experiencing recurrent implantation failure (RIF) after IVF/ET compared with controls. METHOD OF STUDY: Thirty women experiencing RIF after IVF/ET and 10 fertile women participated in the study. All women had endometrial biopsies taken in the luteal phase of their menstrual cycle for an endometrial immune profile (EIP) and HHV-6 mRNA as well as lymphocyte and granulocyte populations. The prevalence of HHV-6 in endometrial biopsies was determined, and biopsies for positive and negative expression of HHV-6 were compared with the results of their EIP and lymphocyte and granulocyte populations...
April 17, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29655662/evaluation-of-low-intensity-anti-coagulation-with-a-fully-magnetically-levitated-centrifugal-flow-circulatory-pump-the-magentum-1-study
#14
Ivan Netuka, Peter Ivák, Zuzana Tučanová, Stanislav Gregor, Ondrej Szárszoi, Poornima Sood, Daniel Crandall, Jessica Rimsans, Jean Marie Connors, Mandeep R Mehra
BACKGROUND: The HeartMate 3 left ventricular assist system is engineered to avoid pump thrombosis, yet bleeding complications persist. We investigated the safety of low-intensity anti-coagulation in patients with the HeartMate 3. METHODS: The Minimal AnticoaGulation EvaluatioNTo aUgment heMocompatibility (MAGENTUM 1) pilot study is a prospective, single-arm study of low-intensity warfarin anti-coagulation in patients implanted with the HeartMate 3 pump. After standard warfarin anti-coagulation (international normalized ratio [INR] 2...
March 27, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29648896/does-the-dysregulation-of-matrix-metalloproteinases-contribute-to-recurrent-implantation-failure
#15
Mustapha Benkhalifa, Yosra Zayani, Véronique Bach, Henri Copin, Moncef Feki, Moncef Benkhalifa, Monia Allal-Elasmi
The progress in in vitro fertilization (IVF) techniques for infertility management has led to the investigation of embryo implantation site proteins such as Matrix metalloproteinases (MMPs), which may have a key role in embryo-endometrium crosstalk and in the molecular mechanisms of the embryo implantation. Areas covered: Numerous studies have generated much information concerning the relation between the different proteins at the site of implantation such as cytokines, growth factors, adhesion molecules and MMPs...
April 12, 2018: Expert Review of Proteomics
https://www.readbyqxmd.com/read/29629921/assessment-of-cardiac-thrombosis-in-patients-with-left-ventricular-assist-device-using-multidetector-cardiac-computed-tomography
#16
Chukwuemeka A Obi, Nicholas Chan, Monica G Rizkalla, John N Makaryus
: A 79-year-old man with nonischemic cardiomyopathy who underwent left ventricular assist device HeartMate II and automated implantable cardioverter defibrillator placement presented with recurrent refractory sustained ventricular tachycardia, elevated lactate dehydrogenase, and low haptoglobin. Echocardiography demonstrated no thrombosis; cardiac computed tomography showed patent inflow and outflow cannulas while detecting an irregularly shaped mass adherent to the left coronary cusp of the aortic valve, suggesting a thrombus...
April 7, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29619396/anthropometric-and-radiologic-measurements-of-coracoid-dimensions-and-clinical-implications-in-an-indian-population
#17
Deepak Joshi, Lalit Mohan Gupta, Milind Tanwar, Ajay Lal, Deepak Chaudhary
Background: Recurrent shoulder dislocation and anterior instability are most commonly attributed to pathology of the capsulolabral complex with the presence of bony loss at the humeral and glenoid surfaces. Unassessed bone loss has been a cause of failure of primary soft tissue procedures or recurrence of symptoms, despite adequate address of soft tissue pathology. Purpose: To study the anthropometric and radiologic dimensions of the coracoid in relation to glenoid bone loss, its adequacy in filling glenoid defects in an Indian population, and whether the choice of surgical technique (congruent arc vs classical) and graft positioning alters the surgical results...
March 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29617817/decreased-pecam1-mediated-tgf-%C3%AE-1-expression-in-the-mid-secretory-endometrium-in-women-with-recurrent-implantation-failure
#18
Feng Guo, Chenchen Si, Mingjuan Zhou, Jingwen Wang, Dan Zhang, Peter C K Leung, Bufang Xu, Aijun Zhang
STUDY QUESTION: Is recurrent implantation failure (RIF) associated with decreased expression of platelet and endothelial cell adhesion molecule 1 (PECAM1) and transforming growth factor β1 (TGF-β1) in the endometrium during the implantation window? SUMMARY ANSWER: The present study demonstrates that the expression of PECAM1 and TGF-β1 is significantly decreased in the mid-secretory endometrium in women with RIF, which may account for embryo implantation failure...
March 30, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29603821/lymphocytes-immunotherapy-for-preserving-pregnancy-mechanisms-and-challenges
#19
REVIEW
Hamed Hajipour, Hamid Reza Nejabati, Zeinab Latifi, Kobra Hamdi, Zahra Bahrami-Asl, Amir Fattahi, Mohammad Nouri
Due to the expression of paternal antigens by the embryo, pregnancy is considered as a semi-allograft and so immunological dysregulation is considered as one of the important causes in repeated implantation failure (RIF) and recurrent pregnancy loss (RPL). It has been revealed that lymphocytes immunotherapy (LIT) could be an appropriate approach to prevent pregnancy loss in such patients. Various mechanisms have been suggested for effectiveness of LIT such as enhancing expression of anti-paternal cytotoxic antibodies (APCA), progesterone-induced blocking factor (PIBF), anti-idiotypic antibodies (Ab2), and mixed lymphocyte reaction blocking antibodies (MLR-Bf), as well as reduction in the T helper 1/T helper 2 ratio and deviation in the pattern of cytokines production...
March 31, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29601924/anterior-urethroplasty-using-a-new-tissue-engineered-oral-mucosa-graft-surgical-techniques-and-outcomes
#20
Guido Barbagli, Ilgar Akbarov, Axel Heidenreich, Vahudin Zugor, Roberto Olianas, Maurizio Aragona, Giuseppe Romano, Ulf Balsmeyer, Dirk Fahlenkamp, Udo Rebmann, Diana Standhaft, Massimo Lazzeri
PURPOSE: We investigated if the tissue-engineered material may be adopted using the standard techniques for anterior urethroplasty. MATERIALS AND METHOD: Retrospective, multicenter study including patients with recurrent strictures and excluding patients with failed hypospadias, lichen sclerosus, traumatic and posterior strictures. An oral mucosa biopsy of 0.5 cm2 was taken from patient's cheek and sent to the laboratory for manufacturing the graft. After 3 weeks, the tissue engineered oral mucosal graft (MukoCell®) was sent to the hospital for urethroplasty...
March 27, 2018: Journal of Urology
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