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Recurrent implantation failure

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https://www.readbyqxmd.com/read/28815854/expression-of-natural-cytotoxicity-receptors-and-cytokine-production-on-endometrial-natural-killer-cells-in-women-with-recurrent-pregnancy-loss-or-implantation-failure-and-the-expression-of-natural-cytotoxicity-receptors-on-peripheral-blood-natural-killer-cells
#1
Atsushi Fukui, Ayano Funamizu, Rie Fukuhara, Hiroaki Shibahara
AIM: Natural cytotoxicity receptors (NCR) are unique markers that regulate natural killer (NK) cell cytotoxicity and cytokine production. In this study, we investigated the expression of NCR (NKp46, NKp44, and NKp30) and cytokine production in NK cells derived from the uterine endometrium of women with recurrent pregnancy loss (RPL). We also investigated the expression of NCR in peripheral blood NK cells in pregnant women with and without a history of RPL. METHODS: The expression of NCR (NKp46, NKp44, and NKp30) in NK cells (CD56(dim) and CD56(bright) ) in the uterine endometrium was analyzed using 3-color flow cytometry...
August 17, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28807532/multicenter-evaluation-of-biochemical-relapse-free-survival-outcomes-for-intraoperatively-planned-prostate-brachytherapy-using-an-automated-delivery-system
#2
Kevin Martell, Siraj Husain, Daniel Taussky, Steve Angyalfi, Guila Delouya, Philippe Després, Luc Beaulieu, Andre-Guy Martin, Eric Vigneault
PURPOSE: To report biochemical recurrence in prostate cancer treated with intraoperatively planned low-dose-rate prostate brachytherapy using an automated delivery system (IO-LDRB). METHODS AND MATERIALS: Between 2003 and 2013, 2608 patients from 3 centers were treated with IO-LDRB as single-modality treatment for low or low-tier intermediate-risk prostate cancer. Databases from the 3 centers have been analyzed. These independent databases were collected prospectively...
June 6, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28807395/clinical-validation-of-pinopode-as-a-marker-of-endometrial-receptivity-a-randomized-controlled-trial
#3
Zhang Qiong, Hao Jie, Wang Yonggang, Xu Bin, Zhao Jing, Li Yanping
OBJECTIVE: To determine the clinical value of pinopodes in the human. DESIGN: Randomized controlled trial. SETTING: Academic fertility center. PATIENT(S): From December 2014 to December 2016, in a phase I trial, 363 patients were recruited in their first IVF cycles. In a phase II trial, 136 patients with at least two previous embryo implantation failures were recruited. INTERVENTION(S): In the phase I trial, in the midluteal phase, endometrial tissues were obtained for scanning electron microscopy, and their IVF treatment outcomes were followed up...
August 11, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28805198/severe-reversible-hypocalcemic-cardiomyopathy-diagnosed-36-years-after-subtotal-thyroidectomy-a-case-report
#4
Waldemar Elikowski, Małgorzata Małek-Elikowska, Patrycja Lachowska-Kotowska
Chronic hypocalcemia, irrespectively of its etiology, can lead to severe impairment of the left ventricular (LV) contractility manifesting as dilated cardiomyopathy, usually defined as hypocalcemic cardiomyopathy (hypocaCM). This rarely diagnosed type of heart failure (HF), can be completely reversible, when treated properly with calcium and vitamin D supplementation or, in some subjects, with human recombinant parathormone. A CASE REPORT: The authors present a case of a 60-year-old male admitted with advanced pulmonary congestion, recurrent pulmonary edema and pleural effusion...
July 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28777390/thrombosis-in-left-ventricular-assistance-device-with-centrifugal-technology-is-early-thrombolysis-a-better-solution
#5
Paolo Centofanti, Andrea Baronetto, Matteo Attisani, Davide Ricci, Erika Simonato, Michele W La Torre, Massimo Boffini, Mauro Rinaldi
BACKGROUND: Continuous flow left ventricular assistance devices (CF-LVADs) have revolutionized the treatment of advanced heart failure. Pump replacement for thrombosis is a high-risk procedure with a high perioperative mortality rate with possible recurrence. We aim to summarize our experience using a conservative approach with medical therapy. METHODS: We retrospectively reviewed records of patients who experienced pump thrombosis after LVAD implantation with HeartWare HVAD at our institution, from November 2010 to March 2016...
July 27, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28770293/case-series-of-patients-with-pathological-dyaphiseal-fractures-from-metastatic-bone-disease
#6
Dinu Vermesan, Radu Prejbeanu, Horia Haragus, Alis Dema, Manuel D Oprea, Diana Andrei, Dan V Poenaru, Marius Niculescu
INTRODUCTION: Fractures on pathologic bone have major impact on life quality. The appropriate treatment is not standardized, but the current literature delineates that surgery must provide adequate stabilization for the life expectancy. We aimed to review the epidemiology, treatment outcomes and survival in our department. MATERIAL AND METHODS: The electronic database from a major referral centre was searched for patients treated for tumours and fractures by the corresponding ICM-10 codes over five years...
August 2, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28758179/clinical-outcomes-of-posterior-c1-and-c2-screw-rod-fixation-for-atlantoaxial-instability
#7
Hasan Serdar Işik, Evren Sandal, Sedat Çağli
AIM: In this study, we aimed at sharing our experiences and contributing to the literature by making a retrospective analysis of the patients we operated with screw-rod system for atlantoaxial instability in our clinic. MATERIAL AND METHODS: Archive files of adult patients, who were operated for posterior C1-C2 stabilization with screw and rod in our clinic between January 2006 and January 2016, were analyzed. 28 patients, who had pre and post-operative images, follow-up forms and who were followed for at least one year, were analyzed...
June 14, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28743612/clinical-outcomes-after-interstitial-brachytherapy-for-early-stage-nasal-squamous-cell-carcinoma
#8
Warren Bacorro, Alexandre Escande, Stéphane Temam, Isabelle Dumas, Emilie Routier, Marie-Catherine Gensse, Pierre Blanchard, François Janot, Christine Mateus, Yungan Tao, Caroline Robert, Eric Deutsch, Christine Haie-Meder, Cyrus Chargari
PURPOSE: Radiotherapy of nasal carcinomas results in cure rates comparable to surgery, with anatomic preservation and good cosmesis. Brachytherapy (BT) overcomes difficulties with dosimetric coverage and affords a localized and highly conformal irradiation. We report our experience of BT for early-stage nasal squamous cell carcinomas (SCCs). METHODS AND MATERIALS: Clinical data, BT parameters, and outcome of consecutive patients treated by interstitial BT in our institute between December 1982 and April 2015 for a localized nasal SCC were examined...
July 22, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28721889/clinical-outcomes-of-large-brain-metastases-treated-with-neurosurgical-resection-and-intraoperative-cesium-131-brachytherapy-results-of-a-prospective-trial
#9
A Gabriella Wernicke, Cole B Hirschfeld, Andrew W Smith, Shoshana Taube, Menachem Z Yondorf, Bhupesh Parashar, Lucy Nedialkova, Fridon Kulidzhanov, Samuel Trichter, Albert Sabbas, Rohan Ramakrishna, Susan Pannullo, Theodore H Schwartz
PURPOSE: Studies on adjuvant stereotactic radiosurgery to the cavity of resected brain metastases have suggested that larger tumors (>2.0 cm) have greater rates of recurrence and radionecrosis (RN). The present study assessed the effect of permanent low-dose (131)Cs brachytherapy on local control and RN in patients treated for large brain metastases. METHODS AND MATERIALS: After institutional review board approval, 42 patients with 46 metastases ≥2.0 cm in preoperative diameter were accrued to a prospective trial from 2010 to 2015...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28707148/chemokine-c-c-motif-ligand-2-ccl2-and-oxidative-stress-markers-in-recurrent-pregnancy-loss-and-repeated-implantation-failure
#10
Müberra Namlı Kalem, Nilufer Akgun, Ziya Kalem, Batuhan Bakirarar, Tugrul Celik
PURPOSE: The main purpose of this study is to evaluate the inflammatory response and oxidative stress together in the cases of recurrent pregnancy loss (RPL) and repeated implantation failure (RIF). METHODS: This is a cross-sectional study conducted to compare infertile patients who have RIF and patients with RPL histories in terms of CCL2, TAS, TOS, and OSI. To this end, two study groups were formed by primary-infertile women with RIF history and women with nulliparous RPL history who consulted a university hospital between 2014 and 2016, and a control group was formed by multiparous women who had no pregnancy loss...
July 13, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28707147/the-hla-g-14-bp-polymorphism-and-recurrent-implantation-failure-a-meta-analysis
#11
REVIEW
Wei Fan, Zhongying Huang, Shangwei Li, Zhun Xiao
PURPOSE: The human leucocyte antigen-G (HLA-G) 14-bp insertion/deletion polymorphism was implicated in recurrent implantation failure (RIF), but individual published studies showed inconclusive results. Thus, a meta-analysis was performed to clarify the effect of HLA-G 14-bp polymorphism on RIF risk. METHODS: A comprehensive search for relevant articles was conducted. The odds ratios (ORs) and 95% confidence intervals (CIs) for HLA-G 14-bp polymorphism and RIF were calculated...
July 13, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28704242/long-term-clinical-outcome-after-implantation-of-the-self-expandable-stentys-stent-in-a-large-multicenter-cohort
#12
Luise Gaede, Christoph Liebetrau, Oliver Dörr, Johannes Blumenstein, Albrecht Elsässer, Christian W Hamm, Helge Möllmann, Christian Schlundt, Holger M Nef, Stephan Achenbach
OBJECTIVE: The objective of the study was to retrospectively evaluate the long-term clinical outcome after implantation of the self-expandable (SE) STENTYS stent in a large multicenter cohort. BACKGROUND: Incomplete stent apposition is known to cause higher rates of myocardial infarction (MI) and stent thrombosis. Because of its self-expanding features, the SE STENTYS stent adapts to the vessel wall and is therefore expected to minimize malapposition and therefore the rates of MI and stent thrombosis...
July 12, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28699111/hla-class-ib-in-pregnancy-and-pregnancy-related-disorders
#13
REVIEW
Gry Persson, Wenna Nascimento Melsted, Line Lynge Nilsson, Thomas Vauvert F Hviid
The HLA class Ib genes, HLA-E, HLA-F, and HLA-G, were discovered long after the classical HLA class Ia genes. The elucidation of their functions had a modest beginning. However, their basic functions and involvement in pathophysiology and a range of diseases are now emerging. Although results from a range of studies support the functional roles for the HLA class Ib molecules in adult life, especially HLA-G and HLA-F have most intensively been, and were also primarily, studied in relation to reproduction and pregnancy...
July 11, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28692907/mechanical-properties-of-the-abdominal-wall-and-biomaterials-utilized-for-hernia-repair
#14
REVIEW
Corey R Deeken, Spencer P Lake
Abdominal wall hernias are one of the most common and long-standing surgical applications for biomaterials engineering. Yet, despite over 50 years of standard use of hernia repair materials, revision surgery is still required in nearly one third of patients due to hernia recurrence. To date, hernia mesh designs have focused on maximizing tensile strength to prevent structural failure of the implant. However, most recurrences occur at the biomaterial-tissue interface. There is a fundamental gap in understanding the degree to which a mechanical mismatch between hernia repair materials and host tissue contributes to failure at this interface...
May 6, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28691531/survival-analysis-of-the-wallis-interspinous-spacer-used-as-an-augment-to-lumbar-decompression
#15
Jamie A Nicholson, Chloe E H Scott, Andrew D Duckworth, John G Burke, John N Alastair Gibson
OBJECT: The Wallis fixed interspinous spacer may augment traditional decompression in the treatment of lumbar spinal stenosis. The aim of this study was to determine factors influencing survival of the Wallis interspinous spacer and to identify specific modes and predictors of failure. METHODS: We performed a retrospective cohort study of 244 Wallis interspinous spacers implanted in 195 consecutive patients with a mean age of 56 years (range 21-87) to augment single or multi-level decompression...
July 8, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28690381/polymorphism-of-the-pai-1gene-4g-5g-may-be-linked-with-polycystic-ovary-syndrome-and-associated-pregnancy-disorders-in-south-indian-women
#16
Maniraja Jesintha Mary, Lakshmanan Saravanan, Munuswamy Deecaraman, Melantharu Vijayalakshmi, Vetrivel Umashankar, Jaigopal Sailaja
Polycystic Ovary syndrome (PCOS) is the most common endocrine disorder affecting 5 - 10% of all women of reproductive age group. The present research was carried out to study the impact of Plasminogen Activator Inhibitor (PAI-1) 4G/5G polymorphism (rs1799889) in PCOS, and the risk of developing PCOS in South Indian Population. The study was carried out in 60 subjects of South Indian population (30 PCOS and 30 Non PCOS) recruited from ARC Research and Fertility Centre, Chennai, India. Genotype and Allelic frequencies were compared by Fisher exact test, Hardy Weinberg equilibrium...
2017: Bioinformation
https://www.readbyqxmd.com/read/28690039/retained-antibiotic-spacers-after-total-hip-and-knee-arthroplasty-resections-high-complication-rates
#17
Stephen M Petis, Kevin I Perry, Mark W Pagnano, Daniel J Berry, Arlen D Hanssen, Matthew P Abdel
BACKGROUND: Prolonged retention of an antibiotic spacer is occasionally chosen during treatment of periprosthetic joint infections after total hip arthroplasty (THA) and total knee arthroplasty (TKA). The purpose of our study was to evaluate the outcome of extended spacer retention. METHODS: We reviewed 1106 cases of periprosthetic joint infection after THA (n = 308) and TKA (n = 798) and identified 17 (5.5%) retained hip and 34 (4.3%) retained knee spacers. Most patients (35 of 51, 69%) underwent spacer retention because they were medically unfit for further surgery...
June 8, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28689824/extra-articular-shoulder-resections-outcomes-of-54-patients
#18
Andrea Angelini, Andreas F Mavrogenis, Giulia Trovarelli, Elisa Pala, Pablo Arbelaez, Josè Casanova, Antonio Berizzi, Pietro Ruggieri
BACKGROUND: The survival of patients with tumors around the shoulder treated with extra-articular resection, the rates of reconstructions-related complications, and the function of the shoulder cannot be estimated because of limited available data from mainly small published related series and case reports. METHODS: We studied 54 patients with tumors around the shoulder treated with extra-articular shoulder resections and proximal humeral megaprosthetic reconstructions from 1985 to 2012...
July 6, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28689771/immunosuppression-with-tacrolimus-improved-implantation-and-rescued-expression-of-uterine-progesterone-receptor-and-its-co-regulators-fkbp52-and-piasy-at-nidation-in-the-obese-and-diabetic-mice-comparative-studies-with-metformin
#19
Ahmad J H Albaghdadi, Frederick W K Kan
Diabesity is often associated with subfertility and recurrent miscarriages. Evidence links systemic and local uterine cytotoxicity to the pathogenesis of implantation failure (IF) in diabetes. Immunosuppression with tacrolimus improved pregnancy outcomes in obese and diabetic mice and repeated IF in women with elevated Th1/Th2 blood cell ratios. However the mode of action of tacrolimus in protecting against IF and the molecular mechanisms associated with recurrent miscarriages in the obese and diabetic subjects are yet to be elucidated...
July 6, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28672755/pregnancy-outcomes-among-patients-with-recurrent-pregnancy-loss-and-chromosomal-aberration-ca-without-pgd
#20
Maor Kabessa, Avi Harlev, Michael Friger, Ruslan Sergienko, Baila Litwak, Arie Koifman, Naama Steiner, Asher Bashiri
BACKGROUND: Recurrent pregnancy loss (RPL) is defined by two or more failed clinical pregnancies. Three to four percent of the couples with RPL have chromosomal aberrations (CA) in at least one partner. The parent's structural chromosomal abnormalities may cause an unbalanced karyotype in the conceptus which could lead to implantation failure, early or late pregnancy loss, or delivery of a child with severe physical and/or mental disabilities. OBJECTIVE: To compare live birth rates of couples with CA to couples with normal karyotypes and to investigate medical and obstetric characteristics and pregnancy outcomes of couples with CA and RPL who attend an RPL clinic at a tertiary hospital...
June 26, 2017: Journal of Perinatal Medicine
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