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https://www.readbyqxmd.com/read/29331965/right-iliac-fossa-pain-treatment-rift-study-protocol-for-an-international-multicentre-prospective-observational-study
#1
Dmitri Nepogodiev
INTRODUCTION: Patients presenting with right iliac fossa (RIF) pain are a common challenge for acute general surgical services. Given the range of potential pathologies, RIF pain creates diagnostic uncertainty and there is subsequent variation in investigation and management. Appendicitis is a diagnosis which must be considered in all patients with RIF pain; however, over a fifth of patients undergoing appendicectomy, in the UK, have been proven to have a histologically normal appendix (negative appendicectomy)...
January 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29305543/genotyping-multi-drug-resistant-m-tuberculosis-from-primary-sputum-and-decontaminated-sediment-with-an-integrated-microfluidic-amplification-microarray
#2
Yvonne Linger, Christopher Knickerbocker, David Sipes, Julia Golova, Molly Franke, Roger Calderon, Leonid Lecca, Nitu Thakore, Rebecca Holmberg, Peter Qu, Alexander Kukhtin, Megan B Murray, Christopher G Cooney, Darrell P Chandler
There is a growing awareness that molecular diagnostics for detect-to-treat applications will soon need a highly multiplexed mutation detection and identification capability. In this study, we converted an open-amplicon MDR-TB microarray hybridization test into an entirely closed-amplicon consumable (an amplification microarray) and evaluated its performance on matched sputum and sediment extracts. Reproducible genotyping (LoD) was achieved with ∼25 MTB genomes (100 fg of MTB DNA) per reaction; the estimated shelf life of the test was least 18 months when stored at 4°C...
January 5, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29305538/false-positive-xpert-mtb-rif-results-in-re-tested-patients-with-previous-tuberculosis-frequency-profile-and-prospective-clinical-outcomes
#3
Grant Theron, Rouxjeane Venter, Liezel Smith, Aliasgar Esmail, Philippa Randall, Vishesh Sood, Suzette Oelfese, Greg Calligaro, Robin Warren, Keertan Dheda
Introduction: Globally, Xpert MTB/RIF (Xpert) is the most widely-used PCR test for tuberculosis (TB). Positive results in previously-treated patients, which are due to old DNA or active disease, are a diagnostic dilemma.Materials and methods: We prospectively re-tested sputum from 238 patients, irrespective of current symptoms, who were previously-diagnosed as Xpert-positive and treated successfully. Patients who re-tested as Xpert-positive, culture-negative were exhaustively investigated (repeated culture, chest radiography, bronchoscopy with bronchoalveolar lavage, long-term clinical follow-up)...
January 5, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29305460/delays-in-the-diagnosis-and-treatment-of-bone-and-joint-tuberculosis-in-the-united-kingdom
#4
C Broderick, S Hopkins, D J F Mack, W Aston, R Pollock, J A Skinner, S Warren
AIMS: Tuberculosis (TB) infection of bones and joints accounts for 6.7% of TB cases in England, and is associated with significant morbidity and disability. Public Health England reports that patients with TB experience delays in diagnosis and treatment. Our aims were to determine the demographics, presentation and investigation of patients with a TB infection of bones and joints, to help doctors assessing potential cases and to identify avoidable delays. PATIENTS AND METHODS: This was a retrospective observational study of all adults with positive TB cultures on specimens taken at a tertiary orthopaedic centre between June 2012 and May 2014...
January 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29300156/comparative-activity-of-tedizolid-and-glycopeptide-combination-therapies-for-the-treatment-of-staphylococcus-aureus-infections-an-in-vitro-and-in-vivo-evaluation-against-strains-with-reduced-susceptibility-to-glycopeptides
#5
J W Betts, H F Abdul Momin, L M Phee, D W Wareham
PURPOSE: Glycopeptides are widely used for the treatment of meticillin-resistant Staphylococcus aureus (MRSA) infections. Although difficult to detect, isolates with reduced (GISA), hetero (hGISA) or complete (GRSA) resistance to glycopeptides are increasingly reported. Optimal therapy for such strains is unknown. We compared the in vitro and in vivo activity of tedizolid (TED), a recently licensed oxazolidonone, with vancomycin (VAN) and teicoplanin (TEIC) combined with fusidic acid (FD) or rifampicin (RIF) against S...
January 4, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29297956/hysteroscopy-after-repeated-implantation-failure-of-assisted-reproductive-technology-a-meta-analysis
#6
REVIEW
Hanyu Cao, Di You, Mingwei Yuan, Mingrong Xi
We conducted this meta-analysis to explore the prognostic value of outpatient (or office) hysteroscopy (OH) preceding in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles in women who had experienced repeated implantation failure (RIF), particularly in regard to the conflicting evidence reported by previous studies. Two reviewers independently searched Pubmed, MEDLINE, Web of Science, Cochrane Library and Embase to identify all publications of clinical trials of hysteroscopy with or without endometrial biopsy in RIF patients...
January 3, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29290186/evaluation-of-nitrate-reductase-assay-for-early-detection-of-multi-and-extensively-drug-resistance-tuberculosis-in-our-setup
#7
Aamer Ikram Ikram, Muhammad Luqman Satti, Farida Khurram Lalani, Gohar Zaman, Adeel Hussain Gardezi, Parvez Ahmed
OBJECTIVE: To evaluate the performance of nitrate reductase assay on smear positive pulmonary specimens for detection of multi and extensively drug resistant tuberculosis simultaneously. STUDY DESIGN: Cross-sectional analytical study. PLACE AND DURATION OF STUDY: Microbiology Department, Armed Forces Institute of Pathology, Rawalpindi from June to December 2016. METHODOLOGY: Smear positive pulmonary samples were processed both by nitrate reductase method on Lowenstein Jenson medium and also inoculated on gold standard Bactec MGIT 960 TB system...
January 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29285142/increased-levels-of-ccr7-lo-pd-1-hi-cxcr5-cd4-t-cells-and-associated-factors-bcl-6-cxcr5-il-21-and-il-6-contribute-to-repeated-implantation-failure
#8
Qiaoqiao Gong, Yuejie Zhu, Nannan Pang, Haiquan Ai, Xiaoyun Gong, Xiaolin La, Jianbing Ding
In vitro fertilization-embryo transfer (IVF-ET) can be used by infertile couples to assist with reproduction; however, failure of the embryo to implant into the endometrial lining results in failure of the IVF treatment. The present study investigated the expression of chemokine receptor 7 (CCR7)(lo) programmed death-1(PD-1)(hi) chemokine receptor type 5 (CXCR5)+ cluster of differentiation 4 (CD4)+ T cells and associated factors in patients with repeated implantation failure (RIF). A total of 30 females with RIF and 30 healthy females were enrolled in the current study...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29284421/improved-performance-of-xpert-mtb-rif-assay-on-sputum-sediment-samples-obtained-from-presumptive-pulmonary-tuberculosis-cases-at-kibong-oto-infectious-diseases-hospital-in%C3%A2-tanzania
#9
Peter M Mbelele, Said Aboud, Stellah G Mpagama, Mecky I Matee
BACKGROUND: The introduction of Xpert MTB/RIF assay (Xpert) has significantly improved diagnosis of Tuberculosis (TB) in resource limited human immunodeficiency virus (HIV) endemic settings. We aimed to modify the Xpert protocol to improve the detection of Mycobacterium tuberculosis (MTB). METHODS: This cross sectional study was conducted among presumptive pulmonary tuberculosis (PTB) patients at Kibong'oto Infectious Diseases Hospital between August and November 2015...
December 29, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29282012/comparison-of-line-probe-assay-to-bactec-mgit-960-system-for-susceptibility-testing-of-first-and-second-line-anti-tuberculosis-drugs-in-a-referral-laboratory-in-south-africa
#10
Nontuthuko E Maningi, Lesibana A Malinga, John F Antiabong, Ruth M Lekalakala, Nontombi M Mbelle
BACKGROUND: The incidence of multidrug-resistant tuberculosis (MDR-TB) is increasing and the emergence of extensively drug-resistant tuberculosis (XDR-TB) is a major challenge. Controlling resistance, reducing transmission and improving treatment outcomes in MDR/XDR-TB patients is reliant on susceptibility testing. Susceptibility testing using phenotypic methods is labour intensive and time-consuming. Alternative methods, such as molecular assays are easier to perform and have a rapid turn-around time...
December 28, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29275298/association-of-antituberculosis-treatment-and-lower-risk-of-hyperlipidemia-in-taiwanese-patients-a-population-based-case-control-study
#11
Ying-Ray Lee, N I Tien, Cheng-Li Lin, Hsin-Yi Shen, DA-Tian Bau, Yun-Ping Lim
The association between anti-tuberculosis (TB) treatments and the risk of developing hyperlipidemia remains unclear. Data were obtained from the Longitudinal Health Insurance Database 2000 (LHID2000). The case group included patients newly diagnosed with hyperlipidemia (n=16,054) between 2006 and 2011 selected from the LHID2000. A four-fold number of hyperlipidemia-free cases (n=64,216) were matched with case patients by age, sex, and index year to create the control group. Univariable and multivariable unconditional logistic regression analyses were conducted to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for the association between hyperlipidemia and anti-TB medication use...
January 2018: In Vivo
https://www.readbyqxmd.com/read/29259480/efficacy-of-the-endometrial-receptivity-array-for-repeated-implantation-failure-in-japan-a-retrospective-two-centers-study
#12
Tomoko Hashimoto, Masae Koizumi, Masakazu Doshida, Mayumi Toya, Eri Sagara, Nao Oka, Yukiko Nakajo, Nobuya Aono, Hideki Igarashi, Koichi Kyono
Aim: This study aimed to assess the efficacy of the endometrial receptivity array (ERA) as a diagnostic tool and the impact of personalized embryo transfer (pET) for the treatment of patients with recurrent implantation failure (RIF) in Japan. Methods: Fifty patients with a history of RIF with frozen-thawed blastocyst transfers were recruited from July, 2015 to April, 2016. Endometrial sampling for the ERA and histological dating and a pET according to the ERA were performed...
July 2017: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29247181/culture-and-next-generation-sequencing-based-drug-susceptibility-testing-unveil-high-levels-of-drug-resistant-tb-in-djibouti-results-from-the-first-national-survey
#13
Elisa Tagliani, Mohamed Osman Hassan, Yacine Waberi, Maria Rosaria De Filippo, Dennis Falzon, Anna Dean, Matteo Zignol, Philip Supply, Mohamed Ali Abdoulkader, Hawa Hassangue, Daniela Maria Cirillo
Djibouti is a small country in the Horn of Africa with a high TB incidence (378/100,000 in 2015). Multidrug-resistant TB (MDR-TB) and resistance to second-line agents have been previously identified in the country but the extent of the problem has yet to be quantified. A national survey was conducted to estimate the proportion of MDR-TB among a representative sample of TB patients. Sputum was tested using XpertMTB/RIF and samples positive for MTB and resistant to rifampicin underwent first line phenotypic susceptibility testing...
December 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29246776/evaluation-of-loopamp%C3%A2-mtbc-detection-kit-for-diagnosis-of-pulmonary-tuberculosis-at-a-peripheral-laboratory-in-a-high-burden-setting
#14
Van Anh Thi Nguyen, Hung Van Nguyen, Thuong Van Dinh, Ha Hoang Du, Chinh Nhu Do, Guy B Marks, Nhung Viet Nguyen
The Loopamp™MTBC detection kit (TB-LAMP) was designed to replace the sputum smear microscopy for the diagnosis of pulmonary tuberculosis. We evaluated its performance at a peripheral laboratory in Vietnam. The sensitivity of TB-LAMP was 45.5% (28.1%-63.6%), which was equal to 3-sputum smear microscopy but lower than that of Xpert MTB/RIF (87.8% [71.8%-96.6%]). In patients with culture-confirmed TB, sensitivity was 80% (51.9%-95.7%) in smear-positive and 16.7% (3.5%-41.4%) in smear-negative cases. The specificity of TB-LAMP was 95...
November 21, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29243795/the-effect-on-clinical-results-of-adding-recombinant-lh-in-late-phase-of-ovarian-stimulation-of-patients-with-repeated-implantation-failure-a-pilot-study
#15
A Rahman, D Francomano, F Sagnella, F Lisi, C Manna
OBJECTIVE: To evaluate the efficacy of recombinant LH (r-LH) addition in the late phase of ovarian stimulation in patients with repeated implantation failure (RIF). PATIENTS AND METHODS: 66 infertile couples undergoing ICSI treatment due to male factor were allocated to group A (33) and to group B (33). Group A (29 subjects) received recombinant FSH (r-FSH) supplemented by r-LH in the late follicular phase starting the same day of GnRH-antagonist (GnRH-ant) administration, and group B (32 subjects) received r-FSH alone...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29240766/estimated-clinical-impact-of-the-xpert-mtb-rif-ultra-cartridge-for-diagnosis-of-pulmonary-tuberculosis-a-modeling-study
#16
Emily A Kendall, Samuel G Schumacher, Claudia M Denkinger, David W Dowdy
BACKGROUND: The Xpert MTB/RIF (Xpert) assay offers rapid and accurate diagnosis of tuberculosis (TB) but still suffers from imperfect sensitivity. The newer Xpert MTB/RIF Ultra cartridge has shown improved sensitivity in recent field trials, but at the expense of reduced specificity. The clinical implications of switching from the existing Xpert cartridge to the Xpert Ultra cartridge in different populations remain uncertain. METHODS AND FINDINGS: We developed a Markov microsimulation model of hypothetical cohorts of 100,000 individuals undergoing diagnostic sputum evaluation with Xpert for suspected pulmonary TB, in each of 3 emblematic settings: an HIV clinic in South Africa, a public TB center in India, and an adult primary care setting in China...
December 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29232907/a-game-theory-based-incentive-framework-for-an-intelligent-traffic-system-as-part-of-a-smart-city-initiative
#17
Haibo Mei, Stefan Poslad, Shuang Du
Intelligent Transportation Systems (ITSs) can be applied to inform and incentivize travellers to help them make cognizant choices concerning their trip routes and transport modality use for their daily travel whilst achieving more sustainable societal and transport authority goals. However, in practice, it is challenging for an ITS to enable incentive generation that is context-driven and personalized, whilst supporting multi-dimensional travel goals. This is because an ITS has to address the situation where different travellers have different travel preferences and constraints for route and modality, in the face of dynamically-varying traffic conditions...
December 11, 2017: Sensors
https://www.readbyqxmd.com/read/29232592/the-impact-of-oral-arsenic-and-all-trans-retinoic-acid-on-coagulopathy-in-acute-promyelocytic-leukemia
#18
Hong-Hu Zhu, Zhi-Ping Guo, Jin-Song Jia, Qian Jiang, Hao Jiang, Xiao-Jun Huang
The aim of our study was to evaluate the impact of oral arsenic (the realgar-indigo naturalis formula, RIF) and all-trans retinoic acid (ATRA) on coagulopathy in acute promyelocytic leukemia (APL) compared with intravenous arsenic trioxide (ATO) and ATRA during induction. Mitoxantrone was added to all the patients at a dose of 1.4mg/m2 per day for 5-7 days. D-dimer levels, prothrombin time (PT), fibrinogen (Fbg) levels and the platelet count were comparably analyzed among 83 newly diagnosed APL patients treated with RIF (n=45) or with ATO (n=38)...
November 15, 2017: Leukemia Research
https://www.readbyqxmd.com/read/29230533/regulation-of-type-i-collagen-expression-by-microrna-29-following-ionizing-radiation
#19
Hiroyuki Yano, Ryoji Hamanaka, Miki Nakamura-Ota, Juan Juan Zhang, Noritaka Matsuo, Hidekatsu Yoshioka
Radiation-induced fibrosis (RIF) is thought to involve the excessive accumulation of collagen and other extracellular matrix components; previously, we reported that ionizing radiation increased the type I collagen expression and that transforming growth factor (TGF)-β was involved in this increase through activating its downstream mediator, Smad3. A recent study found that microRNAs (miRNAs)-small, noncoding sequences approximately 20 nucleotides long-negatively regulate the gene expression posttranscriptionally, and it has been suggested that miRNAs play essential roles in cellular processes, including fibrosis...
December 11, 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/29226216/prevalence-and-associated-factors-of-tuberculosis-in-prisons-settings-of-east-gojjam-zone-northwest-ethiopia
#20
Mucheye Gizachew Beza, Emirie Hunegnaw, Moges Tiruneh
Background: Tuberculosis, mainly in prisoners, is a major public health problem in Ethiopia where there is no medical screening during prison admission. This creates scarcity of TB data in such settings. Objective: To determine prevalence and associated factors of TB in prisons in East Gojjam Zone, Northwest Ethiopia. Methods: A cross-sectional study was conducted from February to May 2016 among 265 prisoners in three prison sites. Sputum was processed using GeneXpert MTB/RIF...
2017: International Journal of Bacteriology
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