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Kari Branham, Hiroko Matsui, Pooja Biswas, Aditya A Guru, Michael Hicks, John J Suk, He Li, David Jakubosky, Tao Long, Amalio Telenti, Naoki Narai, John R Heckenlively, Kelly A Frazar, Paul A Sieving, Radha Ayyagari
While more than 250 genes are known to cause inherited retinal degenerations (IRD), nearly 40-50% of families have the genetic basis for their disease unknown. In this study we sought to identify the underlying cause of inherited retinal degeneration (IRD) in a family by whole genome sequence (WGS) analysis. Clinical characterization including standard ophthalmic examination, fundus photography, visual field testing, electroretinography, and review of medical and family history was performed. WGS was performed on affected and unaffected family members using Illumina HiSeq X10...
October 7, 2016: Physiological Genomics
Edna Ruiz Magpantay-Monroe
The military and veteran populations in the U. S. state of Hawaii have a strong presence in the local communities. It was this substantial presence that provided the impetus to integrate military and veteran health into a Bachelor's of Science in Nursing (BSN) curriculum. This exploratory study investigated the relationship between the integration of military and veteran health into a psychiatric mental health BSN curriculum and nursing students' understanding of the many facets of military veterans' health...
October 6, 2016: Nurse Education Today
Camille Detree, Gustavo Núñez-Acuña, Steven Roberts, Cristian Gallardo-Escárate
Saxitoxin (STX), a principal phycotoxin contributing to paralytic shellfish poisoning, is largely produced by marine microalgae of the genus Alexandrium. This toxin affects a wide range of species, inducing massive deaths in fish and other marine species. However, marine bivalves can resist and accumulate paralytic shellfish poisons. Despite numerous studies on the impact of STX in marine bivalves, knowledge regarding STX recognition at molecular level by benthic species remains scarce. Therefore, the aim of this study was to identify novel genes that interact with STX in the Chilean mussel Mytilus chilensis...
2016: PloS One
Lisai Zhu, Haibing Lu, Yufeng Cao, Xiaochun Gai, Changming Guo, Yajing Liu, Jiaxu Liu, Xinping Wang
As one of the major pathogens, bovine viral diarrhea virus caused a significant economic loss to the livestock industry worldwide. Although BVDV infections have increasingly been reported in China in recent years, the molecular aspects of those BVDV strains were barely characterized. In this study, we reported the identification and characterization of a novel BVDV isolate designated as SD-15 from cattle, which is associated with an outbreak characterized by severe hemorrhagic and mucous diarrhea with high morbidity and mortality in Shandong, China...
2016: PloS One
Jun Li, Wei Zhen, Dengkai Long, Ling Ding, Anhui Gong, Chenghong Xiao, Weike Jiang, Xiaoqing Liu, Tao Zhou, Luqi Huang
Pseudostellaria heterophylla (Miq.) Pax is a mild tonic herb widely cultivated in the Southern part of China. The tuberous roots of P. heterophylla accumulate high levels of secondary metabolism products of medicinal value such as saponins, flavonoids, and isoquinoline alkaloids. Despite numerous studies on the pharmacological importance and purification of these compounds in P. heterophylla, their biosynthesis is not well understood. In the present study, we used Illumina HiSeq 4000 sequencing platform to sequence the RNA from flowers, leaves, stem, root cortex and xylem tissues of P...
2016: PloS One
Mary E W Dankbaar, Maartje Bakhuys Roozeboom, Esther A P B Oprins, Frans Rutten, Jeroen J G van Merrienboer, Jan L C M van Saase, Stephanie C E Schuit
INTRODUCTION: Training emergency care skills is critical for patient safety but cost intensive. Serious games have been proposed as an engaging self-directed learning tool for complex skills. The objective of this study was to compare the cognitive skills and motivation of medical residents who only used a course manual as preparation for classroom training on emergency care with residents who used an additional serious game. METHODS: This was a quasi-experimental study with residents preparing for a rotation in the emergency department...
October 19, 2016: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
Baukje Miedema, Andrea Bowes, Ryan Hamilton, Stacey Reading
PURPOSE: This study reports on the effect of a group-based nutrition and physical activity intervention program on nutrition knowledge and eating habits in a cohort of people with obesity. METHODS: A quasi-experimental design with pre- and post-test measures. The intervention consisted of physical activity led by certified exercise physiologists and a nutritional education component led by registered dietitians over a 6-month period followed by 6 months of self-management...
October 20, 2016: Canadian Journal of Dietetic Practice and Research
Bria Dexter, Sarah Frank, Louise Seguin
PURPOSE: To understand how and where parents of infants and young children (children ≤5 years old) prefer to receive nutrition information. METHODS: A 1-page survey was developed and pilot tested at 2 community agencies. The final survey was distributed at 18 community health centres (CHCs) in Calgary and surrounding rural areas. Any parent attending a well-child visit (child ≤5 years old) was able to participate. RESULTS: Five hundred and twenty-nine surveys were completed...
October 20, 2016: Canadian Journal of Dietetic Practice and Research
Rafael E Pedro, Débora A Guariglia, Sidney B Peres, Solange M Moraes
BACKGROUND: Human immunodeficiency virus-associated lipodystrophy syndrome (HALS) is a major problem among people living with HIV/aids. The exercise training has been used for its treatment; however, the knowledge about benefits and safety still is emerging. The aim was systematically review the literature for physiological, metabolic, immunologic, and morphologic adaptations to aerobic, resistance, and concurrent training in people living with HALS. METHODS: A search of the Medline, Embase, Cinahl, Lilacs, Scielo, Web of Science, the Cochrane Controlled Trials Register Library and PEDro was performed...
October 20, 2016: Journal of Sports Medicine and Physical Fitness
Jonathan Green
At the outset of the French Revolution John Adams penned a series of Discourses of Davila, philosophical ruminations on the sixteenth-century French Wars of Religion. Recent historians have read these Discourses in terms of Adams's Machiavellianism-his conviction that men's passions lead to violence, if unrestrained. But this reading overlooks the extent to which Adams intended his Discourses as a particular investigation into the French nation's character, and into whether the revolutionaries could lay claim to a native, French tradition of mixed constitutional government...
2016: Journal of the History of Ideas
Matthew S Adams
The work of Herbert Spencer was a crucial influence on the development of Peter Kropotkin's historical sociology. However, scholars have underestimated this relationship; either overlooking it entirely, or minimizing Kropotkin's attachment to Spencer with the aim of maintaining the utility of his political thought in the present. This article contests these interpretations by analyzing Kropotkin's reading of Spencer's epistemological, biological, and political ideas. It argues that Kropotkin was engaged in a critical dialogue with Spencer, incorporating many Spencerian principles in his own system, but also using this reading to articulate a distinctive anarchist politics...
2016: Journal of the History of Ideas
Steven Taylor
At the age of 56, I am glad I never entered into discussion or read any information about altering or tampering with my NHS pension scheme (news, 21 September, page 10 ). I feel the NHS is acting like a loan shark, encouraging people to stop contributing so they have more money in their pocket today, but this will be paid back four-fold in years to come through lost pension income.
October 12, 2016: Nursing Standard
Marc Cornock
Notes made about you while you are in any health setting are not yours. If it is an NHS hospital, they belong to the health secretary; if it is a private hospital, they belong to the consultant or the hospital itself. If something belongs to someone else, you do not have a right to it. The Data Protection Act 1998 allows you to access your health records, but this usually means you receive a copy rather than obtaining and holding the originals.
October 12, 2016: Nursing Standard
(no author information available yet)
Research from Finland suggests a healthy diet is linked to better reading skills in the first 3 years of school.
October 12, 2016: Nursing Standard
(no author information available yet)
1. A sharp rise in safeguarding applications from hospitals has been blamed for more than 75,000 people being deprived of their liberty in England between April 2015 and March 2016. Read more:
October 12, 2016: Nursing Standard
James Charles
BACKGROUND: In clinical and research settings, ankle joint dorsiflexion needs to be reliably measured. Dorsiflexion is often measured by goniometry, but the intrarater and interrater reliability of this technique have been reported to be poor. Many devices to measure dorsiflexion have been developed for clinical and research use. An evaluation of 12 current tools showed that none met all of the desirable criteria. The purpose of this study was to design and develop a device that rates highly in all of the criteria and that can be proved to be highly reliable...
September 2, 2016: Journal of the American Podiatric Medical Association
Markus Ostarek, Gabriella Vigliocco
Previous research has shown that processing words with an up/down association (e.g., bird, foot) can influence the subsequent identification of visual targets in congruent location (at the top/bottom of the screen). However, as facilitation and interference were found under similar conditions, the nature of the underlying mechanisms remained unclear. We propose that word comprehension relies on the perceptual simulation of a prototypical event involving the entity denoted by a word in order to provide a general account of the different findings...
October 20, 2016: Journal of Experimental Psychology. Learning, Memory, and Cognition
(no author information available yet)
Reports an error in "Does Reading a Single Passage of Literary Fiction Really Improve Theory of Mind? An Attempt at Replication" by Maria Eugenia Panero, Deena Skolnick Weisberg, Jessica Black, Thalia R. Goldstein, Jennifer L. Barnes, Hiram Brownell and Ellen Winner (Journal of Personality and Social Psychology, Advanced Online Publication, Sep 19, 2016, np). In the article, due to an error in stimulus construction, four items (three authors, one foil) were omitted from the ART presented to all participants tested by Research Group 1...
November 2016: Journal of Personality and Social Psychology
Payam Safavi-Naeini, Dreema Zafar-Awan, Hongjian Zhu, Gerardo Zablah, Anand V Ganapathy, Abdi Rasekh, Mohammad Saeed, Joanna Esther Molina Razavi, Mehdi Razavi
INTRODUCTION: Current methods for measuring voltage during radiofrequency (RF) ablation (RFA) necessitate turning off the ablation catheter. If voltage could be accurately read without signal attenuation during RFA, turning off the catheter would be unnecessary, allowing continuous ablation. We evaluated the accuracy of the Thermocool SMARTTOUCH catheter for measuring voltage while RF traverses the catheter. METHODS AND RESULTS: We studied 26 patients undergoing RFA for arrhythmias...
October 20, 2016: Journal of Cardiovascular Electrophysiology
Tamara Brussee, Ruth Ma van Nispen, Ger Hmb van Rens
BACKGROUND: Visual acuity (VA) only slightly explains variability in reading performance, whereas other visual and non-visual parameters have been reported to influence reading performance; however, in ophthalmologic and optometric clinical practice and research, where standardised reading tests are used, many of these parameters are often neglected. The purpose of this study was to give insight into how various visual and non-visual parameters are associated with reading performance in normally sighted subjects...
October 20, 2016: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
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