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https://www.readbyqxmd.com/read/28240000/endometriosis-and-ovarian-cancer-an-integrative-review-endometriosis-and-ovarian-cancer
#1
Aline Veras Morais Brilhante, Kathiane Lustosa Augusto, Manuela Cavalcante Portela, Luiz Carlos Gabriele Sucupira, Luiz Adriano Freitas Oliveira, Ana Juariana Magalhães Veríssimo Pouchaim, Lívia Rocha Mesquita Nóbrega, Thaís Fontes de Magalhães, Leonardo Robson Pinheiro Sobreira
Despite being initially considered a benign disease, it is widely thought nowadays that endometriosis and especially ovarian endometriomas are neoplastic conditions with the potential to become malignant. This review was conducted to summarize, in a concise and systematic manner, the available scientific data relating endometriosis to ovarian cancer, published in the past five years. After reading abstracts and applying our predefined inclusion and exclusion criteria, a final list of 11 scientific papers was obtained and subjected to review...
1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28239975/preparing-to-read-the-ubiquitin-code-top-down-analysis-of-unanchored-ubiquitin-tetramers
#2
Amanda E Lee, Lucia Geis-Asteggiante, Emma K Dixon, Meredith Miller, Yan Wang, David Fushman, Catherine Fenselau
The characterization of polyubiquitin chains has been an analytical challenge for several decades. It has been shown that anchored and unanchored polyubiquitin chains with different isopeptide linkages and lengths exhibit a wide range of profoundly different cellular functions. However, structure function studies have been hindered by the difficulty of characterizing these complex chain structures. This report presents a broadly applicable workflow to characterize ubiquitin tetramers without the need for genetic mutations or reiterative immunoprecipitations...
August 2016: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28239926/documenting-dna-in-the-dust
#3
M T P Gilbert
I bought a robotic vacuum cleaner this summer and set it to work. Although my initial expectations were not high, my robot (christened Buddy) finished its cleaning cycle, and then insistently demanded that I empty its dust collection box. As I took the box out, my jaw dropped. I live in a modern house, we don't have pets, and I like to think that I keep it reasonably dust free. But, there was much dust in that box. And when I ran it again 2 days later, the same thing happened. And indeed, every 2 days, Buddy dutifully goes to work, and sucks up a similarly impressive quantity...
February 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28239921/it-s-about-time-revisiting-temporal-processing-deficits-in-dyslexia
#4
Laurence Casini, Catherine Pech-Georgel, Johannes C Ziegler
Temporal processing in French children with dyslexia was evaluated in three tasks: a word identification task requiring implicit temporal processing, and two explicit temporal bisection tasks, one in the auditory and one in the visual modality. Normally developing children matched on chronological age and reading level served as a control group. Children with dyslexia exhibited robust deficits in temporal tasks whether they were explicit or implicit and whether they involved the auditory or the visual modality...
February 27, 2017: Developmental Science
https://www.readbyqxmd.com/read/28239889/the-dark-corner-of-the-heart-understanding-and-embracing-suffering-as-portrayed-by-adults
#5
Jessica Hemberg
BACKGROUND: Suffering profoundly touches the human being's inner existence. The different faces of suffering may yet be unknown, and therefore, it is important to further explore suffering in order to reach a new and deeper understanding of it and its alleviation. THE AIM AND RESEARCH QUESTIONS: The aim of this study was to expand the understanding of suffering. The research questions are what is suffering as described by the human beings themselves and what initiates a movement in suffering towards its alleviation? RESEARCH DESIGN, PARTICIPANTS AND RESEARCH CONTEXT: The study uses a hermeneutical approach and hermeneutical reading...
February 26, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28239666/making-the-most-of-rna-seq-pre-processing-sequencing-data-with-opossum-for-reliable-snp-variant-detection
#6
Laura Oikkonen, Stefano Lise
Identifying variants from RNA-seq (transcriptome sequencing) data is a cost-effective and versatile alternative to whole-genome sequencing. However, current variant callers do not generally behave well with RNA-seq data due to reads encompassing intronic regions. We have developed a software programme called Opossum to address this problem. Opossum pre-processes RNA-seq reads prior to variant calling, and although it has been designed to work specifically with Platypus, it can be used equally well with other variant callers such as GATK HaplotypeCaller...
January 17, 2017: Wellcome Open Res
https://www.readbyqxmd.com/read/28239620/analysis-of-phagosomal-antigen-degradation-by-flow-organellocytometry
#7
Eik Hoffmann, Anne-Marie Pauwels, Andrés Alloatti, Fiorella Kotsias, Sebastian Amigorena
Professional phagocytes internalize self and non-self particles by phagocytosis to initiate innate immune responses. After internalization, the formed phagosome matures through fusion and fission events with endosomes and lysosomes to obtain a more acidic, oxidative and hydrolytic environment for the degradation of its cargo. Interestingly, phagosome maturation kinetics differ between cell types and cell activation states. This protocol allows to quantify phagosome maturation kinetics on a single organelle level in different types of phagocytes using flow cytometry...
November 20, 2016: Bio-protocol
https://www.readbyqxmd.com/read/28239549/red-legged-partridge-alectoris-rufa-de-novo-transcriptome-assembly-and-identification-of-gene-related-markers
#8
Natalia Sevane, Javier Cañon, Paulina G Eusebi, Ignacio Gil, Susana Dunner
The red-legged partridge (Alectoris rufa) has a great socio-economic importance as a game species and is reared by millions in farms in several European countries. The ability to respond to a wide spectrum of pathogens and environmental changes is key for farm-reared animals that, as such, face even higher pathogen exposure and specifically for those submitted to restocking programs. In this study, RNA-sequencing and de-novo assembly of genes expressed in different immune tissues were performed. The raw FASTQ files were submitted to the NCBI SRA database with accession number PRJNA289204...
March 2017: Genomics Data
https://www.readbyqxmd.com/read/28239507/in-the-moment-dissociation-emotional-numbing-and-sexual-risk-the-influence-of-sexual-trauma-history-trauma-symptoms-and-alcohol-intoxication
#9
Cynthia A Stappenbeck, William H George, Jennifer Staples, Hong Nguyen, Kelly Cue Davis, Debra Kaysen, Julia R Heiman, N Tatiana Masters, Jeanette Norris, Cinnamon L Danube, Amanda K Gilmore, Kelly F Kajumulo
OBJECTIVE: Prior research on the effects of sexual trauma has examined dissociation but not emotional numbing during sex and has relied exclusively on retrospective surveys. The present experiment examined associations among distal factors of childhood sexual abuse (CSA), adolescent/adult sexual assault (ASA), and trauma symptoms and the proximal factor of acute alcohol intoxication on in-the-moment dissociation, emotional numbing, and sexual risk intentions. METHOD: Young adult female drinkers (N = 436) at elevated sexual risk were randomized to receive alcohol (target peak breath alcohol concentration = ...
October 2016: Psychology of Violence
https://www.readbyqxmd.com/read/28239471/gene-expression-markers-of-tumor-infiltrating-leukocytes
#10
Patrick Danaher, Sarah Warren, Lucas Dennis, Leonard D'Amico, Andrew White, Mary L Disis, Melissa A Geller, Kunle Odunsi, Joseph Beechem, Steven P Fling
BACKGROUND: Assays of the abundance of immune cell populations in the tumor microenvironment promise to inform immune oncology research and the choice of immunotherapy for individual patients. We propose to measure the intratumoral abundance of various immune cell populations with gene expression. In contrast to IHC and flow cytometry, gene expression assays yield high information content from a clinically practical workflow. Previous studies of gene expression in purified immune cells have reported hundreds of genes showing enrichment in a single cell type, but the utility of these genes in tumor samples is unknown...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28239446/mechanism-of-transcription-coupled-dna-modification-recognition
#11
REVIEW
Ji Hyun Shin, Liang Xu, Dong Wang
As a key enzyme for gene expression, RNA polymerase II (pol II) reads along the DNA template and catalyzes accurate mRNA synthesis during transcription. On the other hand, genomic DNA is under constant attack by endogenous and environmental stresses. These attack cause many DNA lesions. Pol II functions as a specific sensor that is able to recognize changes in DNA sequences and structures and induces different outcomes. A critical question in the field is how Pol II recognizes and senses these DNA modifications or lesions...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/28239355/modification-of-flight-and-locomotion-performances-respiratory-metabolism-and-transcriptome-expression-in-the-lady-beetle-harmonia-axyridis-through-sublethal-pesticide-exposure
#12
Da Xiao, Xiaoling Tan, Wenjuan Wang, Fan Zhang, Nicolas Desneux, Su Wang
Biological control is usually used in combination with chemical control for practical agricultural applications. Thus, the influence of insecticides on the natural predators used for biological control should be investigated for integrated pest management. The ladybird Harmonia axyridis is an effective predator on aphids and coccids. Beta-cypermethrin is a broad-spectrum insecticide used worldwide for controlling insect pests. H. axyridis is becoming increasingly threatened by this insecticide. Here, we investigated the effect of a sublethal dose of beta-cypermethrin on flight, locomotion, respiration, and detoxification system of H...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28239231/genome-wide-discovery-of-dna-polymorphisms-in-mei-prunus-mume-sieb-et-zucc-an-ornamental-woody-plant-with-contrasting-tree-architecture-and-their-functional-relevance-for-weeping-trait
#13
Jie Zhang, Kai Zhao, Dan Hou, Junhuo Cai, Qixiang Zhang, Tangren Cheng, Huitang Pan, Weiru Yang
Next-generation sequencing technologies provide opportunities to ascertain the genetic basis of phenotypic differences, even in the closely related cultivars via detection of large amount of DNA polymorphisms. In this study, we performed whole-genome re-sequencing of two mei cultivars with contrasting tree architecture. 75.87 million 100 bp pair-end reads were generated, with 92 % coverage of the genome. Re-sequencing data of two former upright mei cultivars were applied for detecting DNA polymorphisms, since we were more interested in variations conferring weeping trait...
2017: Plant Molecular Biology Reporter
https://www.readbyqxmd.com/read/28239208/exploring-the-dimensionality-of-morphological-knowledge-for-adolescent-readers
#14
Amanda P Goodwin, Yaacov Petscher, Joanne F Carlisle, Alison M Mitchell
This study examined the dimensionality of morphological knowledge. The performance of 371 seventh- and eighth-graders on seven morphological knowledge tasks was investigated using confirmatory factor analysis. Results suggested that morphological knowledge was best fit by a bifactor model with a general factor of morphological knowledge and seven specific factors, representing tasks that tap different facets of morphological knowledge. Next, structural equation modelling was used to explore links to literacy outcomes...
February 2017: Journal of Research in Reading
https://www.readbyqxmd.com/read/28239154/anti-trypanosomatid-drug-discovery-an-ongoing-challenge-and-a-continuing-need
#15
REVIEW
Mark C Field, David Horn, Alan H Fairlamb, Michael A J Ferguson, David W Gray, Kevin D Read, Manu De Rycker, Leah S Torrie, Paul G Wyatt, Susan Wyllie, Ian H Gilbert
The WHO recognizes human African trypanosomiasis, Chagas disease and the leishmaniases as neglected tropical diseases. These diseases are caused by parasitic trypanosomatids and range in severity from mild and self-curing to near invariably fatal. Public health advances have substantially decreased the effect of these diseases in recent decades but alone will not eliminate them. In this Review, we discuss why new drugs against trypanosomatids are required, approaches that are under investigation to develop new drugs and why the drug discovery pipeline remains essentially unfilled...
February 27, 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28238974/why-american-sign-language-gloss-must-matter
#16
Samuel J Supalla, Jody H Cripps, Andrew P Byrne
Responding to an article by Grushkin on how deaf children best learn to read, published, along with the present article, in an American Annals of the Deaf special issue, the authors review American Sign Language gloss. Topics include how ASL gloss enables deaf children to learn to read in their own language and simultaneously experience a transition to written English, and what gloss looks like and how it underlines deaf children's learning and mastery of English literacy through ASL. Rebuttal of Grushkin's argument includes data describing a deaf child's engagement in reading aloud (entirely in ASL) with a gloss text, which occurred without the breakdown implied by Grushkin...
2017: American Annals of the Deaf
https://www.readbyqxmd.com/read/28238939/unitary-circular-code-motifs-in-genomes-of-eukaryotes
#17
Karim El Soufi, Christian J Michel
A set X of 20 trinucleotides was identified in genes of bacteria, eukaryotes, plasmids and viruses, which has in average the highest occurrence in reading frame compared to its two shifted frames (Michel, 2015; Arquès and Michel, 1996). This set X has an interesting mathematical property as X is a circular code (Arquès and Michel, 1996). Thus, the motifs from this circular code X, called X motifs, have the property to always retrieve, synchronize and maintain the reading frame in genes. The origin of this circular code X in genes is an open problem since its discovery in 1996...
February 23, 2017: Bio Systems
https://www.readbyqxmd.com/read/28238875/the-genomic-and-biological-characterization-of-citrullus-lanatus-cryptic-virus-infecting-watermelon-in-china
#18
Min Xin, Mengji Cao, Wenwen Liu, Yingdang Ren, Chuantao Lu, Xifeng Wang
A dsRNA virus was detected in the watermelon (Citrullus lanatus) samples collected from Kaifeng, Henan province, China through the use of next generation sequencing of small RNAs. The complete genome of this virus is comprised of dsRNA-1 (1603 nt) and dsRNA-2 (1466 nt), both of which are single open reading frames and potentially encode a 54.2kDa RNA-dependent RNA polymerase (RdRp) and a 45.9kDa coat protein (CP), respectively. The RdRp and CP share the highest amino acid identities 85.3% and 75.4% with citrullus lanatus cryptic virus (CiLCV), respectively...
February 23, 2017: Virus Research
https://www.readbyqxmd.com/read/28238762/the-intersubunit-bridge-b1b-of-the-bacterial-ribosome-facilitates-initiation-of-protein-synthesis-and-maintenance-of-translational-fidelity
#19
Silva Lilleorg, Kaspar Reier, Jaanus Remme, Aivar Liiv
In bacteria, ribosomal subunits are connected via 12 intersubunit bridges involving RNA-RNA, RNA-protein and protein-protein interactions. The only protein-protein bridge in the ribosome is B1b, which is mainly formed by the bacterial protein L31 (bL31) and connects the head domain of 30S subunit and the central protuberance of the 50S subunit. It is known to be the most dynamic intersubunit bridge. Here, we have evaluated the role of bL31 and thereby the bridge B1b in the working cycle of the ribosome. First, bL31 deficient ribosomes are severely compromised in their ability to ensure translational fidelity in particular reading frame maintenance in vivo...
February 23, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28238686/expression-and-evolutionary-analyses-of-three-acetylcholinesterase-genes-mi-ace-1-mi-ace-2-mi-ace-3-in-the-root-knot-nematode-meloidogyne-incognita
#20
Ruqiang Cui, Lei Zhang, Yuyan Chen, Wenkun Huang, Chengming Fan, Qingsong Wu, Deliang Peng, Washington da Silva, Xiaotang Sun
The full cDNA of Mi-ace-3 encoding an acetylcholinesterase (AChE) in Meloidogyne incognita was cloned and characterized. Mi-ace-3 had an open reading frame of 1875 bp encoding 624 amino acid residues. Key residues essential to AChE structure and function were conserved. The deduced Mi-ACE-3 protein sequence had 72% amino acid similarity with that of Ditylenchus destructor Dd-AChE-3. Phylogenetic analyses using 41 AChEs from 24 species showed that Mi-ACE-3 formed a cluster with 4 other nematode AChEs. Our results revealed that the Mi-ace-3 cloned in this study, which is orthologous to Caenorhabditis elegans AChE, belongs to the nematode ACE-3/4 subgroup...
February 23, 2017: Experimental Parasitology
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