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Y Xue, J Wang, Y Huang, X Gao, L Kong, T Zhang, M Tang
Silver nanoparticles are used in many commercial products in daily life. Exposure to nanosilver has hepatotoxic effects in animals. This study investigated the cytotoxicity associated with polyvinylpyrrolidone-coated nanosilver (23.44 ± 4.92 nm in diameter) exposure in the human hepatoma cell line (HepG2) and normal hepatic cell line (L02), and the molecular mechanisms induced by nanosilver in HepG2 cells. Nanosilver, in doses of 20-160 μg mL-1 for 24 and 48 h, reduced cell viability in a dose- and time-dependent manner and induced cell membrane leakage and mitochondria injury in both cell lines; these effects were more pronounced in HepG2 cells than in L02 cells...
January 1, 2018: Human & Experimental Toxicology
Barbara Różalska, Beata Sadowska, Aleksandra Budzyńska, Przemysław Bernat, Sylwia Różalska
Due to low efficacy of classic antimicrobial drugs, finding new active preparations attracts much attention. In this study an innovative, cost-effective and environmentally friendly method was applied to produce silver nanoparticles (AgNPs) using filamentous fungi Metarhizium robertsii biomass waste. It was shown that these NPs possess prominent antifungal effects against C. albicans, C. glabrata and C. parapsilosis reference strains. Further detailed studies were performed on C. albicans ATCC 90028. AgNPs kill curve (CFU method and esterase-mediated reduction of fluorescein diacetate); fractionally inhibitory concentration index (FICI) with fluconazole (FLC); effect on fungal cell membrane permeability (propidium iodide (PI) staining), membrane lipids profile (HPLC-MS), yeast morphotypes and intracellular reactive oxygen species level (H2DCFDA probe) were investigated...
2018: PloS One
Narjes Nemati Dil, Mohammad Sadeghi
The present work involves the synthesis of porous gelatin/AcA (PGE-AcA) hydrogel and novel porous gelatin-silver/AcA (NPGESNC-AcA) nanocomposite hydrogel, and their ability as effective biosorbents for the removal of Cu2+ ions from contaminated water. The formation of the samples was confirmed by UV-Vis, TEM, SEM, EDX, DLS, AFM, XRD, TGA/DTG and FTIR techniques. The adsorption studies results showed that maximum monolayer adsorption capacity of copper ions for PGE-AcA was achieved about 130.50 mg g-1 in pH 6...
February 11, 2018: Journal of Hazardous Materials
Svetlana V Fedorenko, Svetlana L Grechkina, Alsu R Mukhametshina, Anastasiya O Solovieva, Tatiana N Pozmogova, Svetlana M Miroshnichenko, Alexander Y Alekseev, Michael A Shestopalov, Kirill V Kholin, Irek R Nizameev, Asiya R Mustafina
The present work introduces composite luminescent nanoparticles (Ag0 -Tb3+ -SNs), where ultra-small nanosilver (4 ± 2 nm) is deposited onto amino-modified silica nanoparticles (35±6 nm) doped by green luminescent Tb(III) complexes. Ag0 -Tb3+ -SNs are able to image cancer (Hep-2) cells in confocal microscopy measurements due to efficient cell internalization, which is confirmed by TEM images of the Hep-2 cells exposed by Ag0 -Tb3+ -SNs. Comparative analysis of the cytotoxicity of normal fibroblasts (DK-4) and cancer cells (Hep-2) incubated with various concentrations of Ag0 -Tb3+ -SNs revealed the concentration range where the toxic effect on the cancer cells is significant, while it is insignificant towards the nonmalignant fibroblasts cells...
February 8, 2018: Journal of Inorganic Biochemistry
Maysa A Elsayed, Abdelmageed M Othman, Mohamed M Hassan, Ali M Elshafei
The fungal-mediated silver nanoparticles (AgNPs) biosynthesis optimization via the application of central composite design (CCD) response surface to develop an effective ecofriendly and inexpensive green process was the aim of the current study. Nanosilver biosynthesis using the Aspergillus niger NRC1731 cell-free filtrate (CFF) was studied through involving the most parameters affecting the AgNPs green synthesis and its interactions effects. The statistical optimization models showed that using 59.37% of CFF in reaction containing 1...
March 2018: 3 Biotech
Hanan B Ahmed, Hossam E Emam, Hamada M Mashaly, Mohamed Rehan
The current approach focuses on studying the leverage of nanosilver (AgNPs) incorporation on the dyeing process of viscose fibers by blue reactive dye. Nanosilver was straightway incorporated into viscose fibers using sodium citrate as nanogenerator. Owing to AgNPs incorporation, color of fibers was turned to greenish-blue and darker greenish color was observed with low Ag content (<1 g/kg). Regardless to the processes sequencing, color strength of fibers was magnified by increasing in Ag content. The constancy of fibers color was not affected by AgNPs inclusion, whatever the processes sequencing and Ag content...
April 15, 2018: Carbohydrate Polymers
Adriano Magesky, Émilien Pelletier
Silver nanoparticles (AgNPs) incorporation in commercial products is increasing due to their remarkable physical and chemical properties and their low cost on the market. Silver has been known for a long time to be highly toxic to bacterial communities, aquatic organisms, and particularly to marine biota. Strong chloro-complexes dominate Ag speciation in seawater and facilitate its persistence in dissolved form. It has a great impact on marine organisms because low concentration of silver can lead to strong bioaccumulation, partly because the neutral silver chloro complex (AgCl 0 ) is highly bioavailable...
2018: Advances in Experimental Medicine and Biology
Merisa B Faiz, Rose Amal, Christopher P Marquis, Elizabeth J Harry, Georgios A Sotiriou, Scott A Rice, Cindy Gunawan
Nanosilver (Ag NPs) is currently one of the most commercialized antimicrobial nanoparticles with as yet, still unresolved cytotoxicity origins. To date, research efforts have mostly described the antimicrobial contribution from the leaching of soluble silver, while the undissolved solid Ag particulates are often considered as being microbiologically inert, serving only as source of the cytotoxic Ag ions. Here, we show the rapid stimulation of lethal cellular oxidative stress in bacteria by the presence of the undissolved Ag particulates...
February 15, 2018: Nanotoxicology
Zhonghua Huang, Mengkun Li, Na Li, Xinyuan Tang, Zhiyu Ouyang
Membrane technology is now being widely used in the field of water treatment for its unique advantages. Layer-by-layer (LbL) self-assembly technique is a convenient and versatile method of modified nanofiltration (NF) membranes fabrication, which can be used to control the thickness and the surface properties of membranes by chemical deposition of polyelectrolytes. Herein, a new kind of composite NF membrane with enhanced antibacterial properties was successfully fabricated through LbL self-assembly method, having polyether sulfone (PES) ultrafiltration (UF) membrane as support layer, N-[(2-hydroxy-3-trimethylammonium)propyl] chloride chitosan (HTCC) and polyacrylic acid (PAA) as active layer, and epichlorohydrin (ECH) as crosslinking reagent...
July 1, 2018: Journal of Nanoscience and Nanotechnology
Shahid Ullah Khan, Tawfik A Saleh, Abdul Wahab, Muhammad Hafeez Ullah Khan, Dilfaraz Khan, Wasim Ullah Khan, Abdur Rahim, Sajid Kamal, Farman Ullah Khan, Shah Fahad
Silver nanotechnology has received tremendous attention in recent years, owing to its wide range of applications in various fields and its intrinsic therapeutic properties. In this review, an attempt is made to critically evaluate the chemical, physical, and biological synthesis of silver nanoparticles (AgNPs) as well as their efficacy in the field of theranostics including microbiology and parasitology. Moreover, an outlook is also provided regarding the performance of AgNPs against different biological systems such as bacteria, fungi, viruses, and parasites (leishmanial and malarial parasites) in curing certain fatal human diseases, with a special focus on cancer...
2018: International Journal of Nanomedicine
Sabine Juling, Linda Böhmert, Dajana Lichtenstein, Axel Oberemm, Otto Creutzenberg, Andreas F Thünemann, Albert Braeuning, Alfonso Lampen
The presence of nano-scaled particles in food and food-related products has drawn attention to the oral uptake of nanoparticles and their interactions with biological systems. In the present study, we used a toxicoproteomics approach to allow for the untargeted experimental identification and comparative analysis of cellular responses in rat liver after repeated-dose treatment with silver nanoparticles, ions, and the coating matrix used for particle stabilization. The proteomic analysis revealed treatment-related effects caused by exposure to silver in particulate and ionic form...
February 3, 2018: Food and Chemical Toxicology
Maryam Shirdel, Hossein Tajik, Mehran Moradi
Purpose: The aim of this study was to investigate antimicrobial and biofilm removal potential of Zataria multiflora essential oil (ZEO) and silver nanoparticle (SNP) alone and in combination on Staphylococcus aureus and Salmonella Typhimurium and evaluate the mechanism of action. Methods: The minimum inhibitory concentration (MIC), and optimal inhibitory combination (OIC) of ZEO and SNP were determined according to fractional inhibitory concentration (FIC) method. Biofilm removal potential and leakage pattern of 260-nm absorbing material from the bacterial cell during exposure to the compounds were also investigated...
December 2017: Advanced Pharmaceutical Bulletin
Ngitheni Winnie-Kate Nyoka, Sthandiwe Nomthandazo Kanyile, Emile Bredenhand, Godfried Jacob Prinsloo, Patricks Voua Otomo
The present study investigated the use of biochar for the alleviation of the toxic effects of a nanosilver colloidal dispersion and a chloronicotinyl insecticide. The survival and reproduction of the potworm Enchytraeus albidus were assessed after exposure to imidacloprid and silver nanoparticles (AgNPs). E. albidus was exposed to 0, 25, 50, 100, 200, and 400 mg imidacloprid/kg and 0, 5, 25, 125, and 625 mg Ag/kg for 21 days in 10% biochar amended and non-biochar amended OECD artificial soil. In both exposure substrates, the effects of imidacloprid on survival were significant in the two highest treatments (p < 0...
February 4, 2018: Environmental Science and Pollution Research International
Dennis G Thomas, Jordan N Smith, Brian D Thrall, Donald R Baer, Hadley Jolley, Prabhakaran Munusamy, Vamsi Kodali, Philip Demokritou, Joel Cohen, Justin G Teeguarden
BACKGROUND: The development of particokinetic models describing the delivery of insoluble or poorly soluble nanoparticles to cells in liquid cell culture systems has improved the basis for dose-response analysis, hazard ranking from high-throughput systems, and now allows for translation of exposures across in vitro and in vivo test systems. Complimentary particokinetic models that address processes controlling delivery of both particles and released ions to cells, and the influence of particle size changes from dissolution on particle delivery for cell-culture systems would help advance our understanding of the role of particles and ion dosimetry on cellular toxicology...
January 25, 2018: Particle and Fibre Toxicology
Ana Paula de Melo Monteiro, Raphael Dias Holtz, Leandro Carneiro Fonseca, Carlos Henrique Zanini Martins, Marcelo de Sousa, Luis Augusto Visani de Luna, Djalma Lucas de Sousa Maia, Oswaldo Luiz Alves
Silver vanadates have been widely investigated because of their many interesting properties and their potential use in several applications. In addition to this, a large number of groups have investigated silver vanadates in the form of nanostructures. Here, we address first the synthesis and properties of nanosilver vanadate. Different techniques, such as precipitation, thermal decomposition, hydrothermal treatment, and sol-gel, are among the methods that have been employed for the controlled synthesis of silver vanadate...
January 11, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
Natalia B Abramenko, Tatiana B Demidova, Еvgeny V Abkhalimov, Boris G Ershov, Eugene Yu Krysanov, Leonid M Kustov
As the worldwide application of silver nanomaterials in commercial products increases every year, and concern about the environmental risks of such nanoparticles also grows. A clear understanding of how different characteristics of nanoparticles contribute in their toxic behavior to organisms are imperative for predicting and control nanotoxicity. Within our research, we investigated the toxic effect of two types of silver nanoparticles (spherical and flat Ag nanoparticles) on zebrafish (Danio rerio) embryos...
April 5, 2018: Journal of Hazardous Materials
Neveen A Salem, Mohammed A Wahba, Wael H Eisa, Marwa El-Shamarka, Wagdy Khalil
Silver and silver oxides are gaining interest in medical applications for their prominent antibacterial and antimicrobial potentials. Recent studies suggest that nanosilver oxide has remarkable anti-inflammatory effects and enhances wound healing. Nevertheless, its effect on gastric ulcer has not yet been illustrated. Thus the current study aimed to explore the prospect protective effect of nanosilver oxide against indomethacin-induced gastric ulcer. A new approach has been followed to synthesize nanosilver oxide...
December 4, 2017: Inflammopharmacology
Amr T M Saeb, Khalid A Al-Rubeaan, Mohamed Abouelhoda, Manojkumar Selvaraju, Hamsa T Tayeb
Background: P. mirabilis is a common uropathogenic bacterium that can cause major complications in patients with long-standing indwelling catheters or patients with urinary tract anomalies. In addition, P. mirabilis is a common cause of chronic osteomyelitis in Diabetic foot ulcer (DFU) patients. We isolated P. mirabilis SCDR1 from a Diabetic ulcer patient. We examined P. mirabilis SCDR1 levels of resistance against Nanosilver colloids, the commercial Nanosilver and silver containing bandages and commonly used antibiotics...
2017: Antimicrobial Resistance and Infection Control
Qiliang Jiang, Shashuang Yu, Xingwang Li, Chuangen Ma, Aixiang Li
A simple approach for the synthesis of Lidocaine-Ibuprofen ionic liquid stabilized silver nanoparticles (IL-AgNPs) was reported in this work. The shape, size and surface morphology of the Lidocaine-Ibuprofen ionic liquid stabilized AgNPs were characterized by using spectroscopic and microscopic techniques such as Ultraviolet-visible spectroscopy (UV-Visible), X-ray diffraction (XRD) analysis, Selected area electron diffraction (SAED), Transmission electron microscopy (TEM). TEM analysis showed the formation of 20-30nm size of IL-AgNPs with very clear lattice fringes...
January 2018: Journal of Photochemistry and Photobiology. B, Biology
M S Makarov, N V Borovkova, M V Storozheva
We studied structural and functional properties of human platelets in the presence of nanosilver particles. Incubation with 0.05-5 μM silver nanoparticles suppressed platelet adhesion in a dose-dependent manner without affecting internal platelet structure; during adhesion, some granules were not exocytized. Spontaneous platelet activation was observed at nanoparticle concentrations 15-100 μM. Addition of 1-5 μM nanosilver to cells undergoing adhesion blocked massive platelet degranulation, but did not prevent the formation of lamellopodia...
December 2017: Bulletin of Experimental Biology and Medicine
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