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https://www.readbyqxmd.com/read/28945041/-dynamic-serum-metabolomics-study-of-liver-injury-in-rats-caused-by-polygonum-multifulorum
#1
Zhi-Jie Ma, Qi Li, Kui-Jun Zhao, Jia-Bo Wang, Xiao-He Xiao
Liquid chromatography-mass spectrometry method was used for determination of metabolic fingerprint spectrum in rat serum, and the method of multivariate statistical analysis was used to compare the metabolism spectrum difference and screen significantly related biomarkers. The dynamic change trend was investigated at the same time. The dynamic metabonomics changes of liver injury in rats caused by Polygonum multifulorum(PM) were investigated; significantly related biomarkers were found and their dynamic change trend was investigated to provide basis for internal mechanism and early clinical diagnosis...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945023/-research-and-application-of-hepatotoxicity-evaluation-technique-of-traditional-chinese-medicine
#2
REVIEW
Jie Song, Rong-Ling Zhong, Zhi Xia, Hao Wu, Qing-Xiang Zhong, Zhen-Hai Zhang, Ying-Jie Wei, Zi-Qi Shi, Liang Feng, Xiao-Bin Jia
The safety of traditional Chinese medicine (TCM) has received the widespread attention in recent years. Hepatotoxicity of TCM is one of the key problems of the safety of TCM. This article summarized research progress and application prospect in the mechanism of TCM hepatotoxicity, biomarkers, toxic omics database, prevention of hepatotoxicity of the liver cell lines, subcellular fraction, three-dimensional cultivation models, the model animals, aiming to provide theoretical basis for TCM toxicity evaluation and technical guidelines, thus promoting the development of TCM toxicity studies...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28944995/comparative-analysis-of-serum-proteome-in-congenital-scoliosis-patients-with-tbx6-haploinsufficiency-a-first-report-pointing-to-lipid-metabolism
#3
Qiankun Zhu, Nan Wu, Gang Liu, Yangzhong Zhou, Sen Liu, Jun Chen, Jiaqi Liu, Yuzhi Zuo, Zhenlei Liu, Weisheng Chen, Yixin Chen, Jia Chen, Mao Lin, Yanxue Zhao, Yang Yang, Shensgru Wang, Xu Yang, Yufen Ma, Jian Wang, Xiaoli Chen, Jianguo Zhang, Jianxiong Shen, Zhihong Wu, Guixing Qiu
Congenital scoliosis (CS) is a three-dimensional deformity of the spine affecting quality of life. We have demonstrated TBX6 haploinsufficiency is the most important contributor to CS. However, the pathophysiology at the protein level remains unclear. Therefore, this study was to explore the differential proteome in serum of CS patients with TBX6 haploinsufficiency. Sera from nine CS patients with TBX6 haploinsufficiency and nine age- and gender-matched healthy controls were collected and analysed by isobaric tagged relative and absolute quantification (iTRAQ) labelling coupled with mass spectrometry (MS)...
September 25, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28944987/the-international-society-for-bipolar-disorders-task-force-report-on-pediatric-bipolar-disorder-knowledge-to-date-and-directions-for-future-research
#4
REVIEW
Benjamin I Goldstein, Boris Birmaher, Gabrielle A Carlson, Melissa P DelBello, Robert L Findling, Mary Fristad, Robert A Kowatch, David J Miklowitz, Fabiano G Nery, Guillermo Perez-Algorta, Anna Van Meter, Cristian P Zeni, Christoph U Correll, Hyo-Won Kim, Janet Wozniak, Kiki D Chang, Manon Hillegers, Eric A Youngstrom
OBJECTIVES: Over the past two decades, there has been tremendous growth in research regarding bipolar disorder (BD) among children and adolescents (ie, pediatric BD [PBD]). The primary purpose of this article is to distill the extant literature, dispel myths or exaggerated assertions in the field, and disseminate clinically relevant findings. METHODS: An international group of experts completed a selective review of the literature, emphasizing areas of consensus, identifying limitations and gaps in the literature, and highlighting future directions to mitigate these gaps...
September 25, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28944956/ethical-challenges-in-biomarker-driven-drug-development
#5
Spencer Phillips Hey
The increasing importance of biomarkers-as drivers of research and drug development activity, surrogate outcomes in clinical trials, and the centerpiece of precision medicine-raises many new ethical challenges. In what follows, I briefly review some of the major ethical challenges and debates already identified in the literature, and then describe a new ethical challenge that arises from the abstract nature of biomarker hypotheses.
September 25, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28944911/microrna%C3%A2-3666-inhibits-breast-cancer-cell-proliferation-by-targeting-sirtuin-7
#6
Di Li, Lifei Li
The abnormal expression of microRNAs (miRNAs) is associated with cancer initiation and progression. miRNAs functioning as oncogenes or tumor suppressors represent novel biomarkers for cancer diagnosis, prognosis, and serve as therapeutic tools. MiR‑3666 has been reported as a tumor suppressor in various types of cancer; however, its role in breast cancer remains unknown. In the current study, the aim was to investigate the potential role of miR‑3666 in breast cancer. It was identified that miR‑3666 was decreased in breast cancer cell lines and that the overexpression of miR‑3666 inhibited breast cancer cell proliferation...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944906/peptidome-analysis-of-amniotic-fluid-from-pregnancies-with-preeclampsia
#7
Yating Qian, Lei Zhang, Can Rui, Hongjuan Ding, Pengyuan Mao, Hongjie Ruan, Ruizhe Jia
Preeclampsia (PE), a life‑threatening, complicated pregnancy‑associated disease, has recently become a research focus in obstetrics. However, the peptidome of the amniotic fluid in PE patients has rarely been investigated. The present study used peptidomic profiling to perform a comparative analysis of human amniotic fluid between normal and PE pregnancies. Centrifugal ultrafiltration and liquid chromatography‑tandem mass spectrometry (LC‑MS/MS) was combined with isotopomeric dimethyl labels to gain a deeper understanding of the role of proteins and the peptidome in the onset of PE...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944900/circulating-mirna%C3%A2-21-is-a-promising-biomarker-for-heart-failure
#8
Jianghua Zhang, Qiang Xing, Xianhui Zhou, Jinxin Li, Yaodong Li, Lin Zhang, Qina Zhou, Baopeng Tang
microRNA 21 (miRNA‑21) promotes the development of cardiac fibrosis, hypertrophy and heart failure. However, whether it can be used as a biomarker for the diagnosis and prognosis of heart failure remains unclear. The current study assessed circulating miRNA‑21 as a viable indicator for diagnosis and prognosis of heart failure. The levels of miRNA‑21 and brain natriuretic peptide were measured in serum obtained from the peripheral vein (miRNA‑21‑PV) and coronary sinus (miRNA‑21‑CS) of 80 patients with heart failure and 40 control individuals via reverse transcription‑quantitative polymerase chain reaction and ELISA, respectively...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944870/effect-of-integrin%C3%A2-linked-kinase-gene-silencing-on-microrna-expression-in-ovarian-cancer
#9
Dandan Yuan, Yilei Zhao, Yang Wang, Jianhua Che, Wenhua Tan, Yuxia Jin, Fei Wang, Peiliang Li, Shuyan Fu, Qian Liu, Wenliang Zhu
Integrin‑linked kinase (ILK) is overexpressed in ovarian cancer (OC), and ILK gene silencing results in apoptosis in OC cells. In the present study, the mechanism by which ILK induces apoptosis was explored from the perspective of microRNA (miRNA) expression. Alterations in the global miRNA expression profile were detected using a miRNA microarray after OC cells were transduced with an ILK small hairpin RNA lentivirus. ILK silencing led to a significant upregulation of 14 miRNAs by at least 1.5‑fold. These findings were validated by reverse transcription‑quantitative polymerase chain reaction...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944858/decreased-expression-of-hsa%C3%A2-mir%C3%A2-372-predicts-poor-prognosis-in-patients-with-gallbladder-cancer-by-affecting-chloride-intracellular-channel-1
#10
Ning Zhou, Wei Cheng, Chuang Peng, Yi Liu, Bo Jiang
It has been reported that hsa‑microRNA (miRNA/miR)‑372 functions as a tumor suppressor or oncogene in various digestive system tumors, however, its roles in gallbladder cancer (GBC) are yet to be established. The present study aimed to determine the expression and clinical relevance of hsa‑miR‑372 in GBC. The expression of hsa‑miR‑372 in 80 pairs of human GBC tissues and adjacent normal gallbladder tissues was measured by reverse transcription‑quantitative polymerase chain reaction. Subsequently, the associations between hsa‑miR‑372 expression levels and the clinicopathological characteristics of patients with GBC were determined using χ2 test...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944852/use-of-immunoproteomics-to-identify-immunogenic-proteins-in-a-rat-model-of-acute-respiratory-distress-syndrome
#11
Zongshu Ji, Haiyan Liu, Linsen Fang, Youxin Yu, Zheng Zhou
Acute respiratory distress syndrome (ARDS) is a common and life‑threatening clinical syndrome, and seeking biomarkers of ARDS has been an area of continuing research. The present study hypothesized that alterations to certain immunogenic substances occur in injured lungs and are able to specifically bind with corresponding proteins in the blood, and that these proteins may be readily detected. To investigate this hypothesis, a rat model of ARDS was established by cecal ligation and puncture surgery, and an immunoproteomics approach, using serum as the primary antibody in a western blot analysis, was used with the aim of identifying immunogenic proteins in the injured lungs...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944850/differentially-expressed-long-non%C3%A2-coding-rnas-and-mrnas-in-patients-with-iga-nephropathy
#12
Nan Zuo, Yun Li, Nan Liu, Lining Wang
Long non‑coding RNAs (lncRNAs) have been reported to serve a crucial role in renal diseases; however, their role in immunoglobulin A nephropathy (IgAN) remains unclear. In the present study, peripheral blood mononuclear cells (PBMCs) were collected from both patients with IgAN and healthy controls. A microarray analysis was then performed to identify differentially expressed lncRNAs and mRNAs in PBMCs, which were confirmed by quantitative polymerase chain reaction. In addition, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and lncRNA‑mRNA co‑expression network analyses were conducted...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944820/identification-of-14%C3%A2-3%C3%A2-3%C3%AE-as-a-potential-biomarker-in-gastric-cancer-by-proteomics%C3%A2-based-analysis
#13
Xin-Xin Liu, Hua Ye, Peng Wang, Yi Zhang, Jian-Ying Zhang
The identification of tumor biomarkers to support early diagnosis and tumor progression monitoring may potentially reduce the mortality of gastric cancer (GC). The present study aimed to detect novel tumor‑associated antigens from the AGS GC cell line, and to identify their associated autoantibodies in sera from patients with GC by proteomics‑based approaches. Proteins from AGS cell lysates were isolated using two‑dimensional polyacrylamide gel electrophoresis, and western blotting was subsequently performed, to determine autoantibody responses in sera derived from patients with GC and healthy individuals...
September 18, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944719/prognostic-value-of-sst2-and-nt-probnp-at-admission-in-heart-failure-with-preserved-mid-ranged-and-reduced-ejection-fraction
#14
Anan Huang, Xin Qi, Wenguang Hou, Yanfang Qi, Na Zhao, Keqaing Liu
OBJECTIVE: The aim of this study was to compare sST2 at admission with N-terminal pro B-type natriuretic peptide (NT-proBNP) in prognostic accuracy among different types of heart failure (HF) and clarifying the enhanced prognostic value in patients with HF by the combination of the two biomarkers. METHODS AND RESULTS: A total of 164 consecutive patients admitted to our institution for HF were divided into three groups of HF with reduced ejection fraction (HFrEF), HF with mid-range ejection fraction (HFmrEF) and HF with preserved ejection fraction (HFpEF)...
September 25, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28944674/analysis-of-o-glycopeptides-by-acetone-enrichment-and-capillary-electrophoresis-mass-spectrometry
#15
Montserrat Mancera-Arteu, Estela Giménez, Fernando Benavente, Jose Barbosa, Victoria Sanz-Nebot
Acetone precipitation was evaluated as a rapid, simple, low-cost and efficient method for the selective purification of O-glycopeptides from enzymatic digests of glycoproteins. Ovalbumin (OVA), human and bovin alpha-1-acid glycoprotein (hAGP and bAGP), human apolipoprotein C-III (APO-C3) and recombinant human erythropoietin (rhEPO) were used to obtain enzymatic digests with a broad and varied set of peptides, N-glycopeptides and O-glycopeptides. After digestion and before capillary electrophoresis mass spectrometry (CE-MS) analysis, the amount of ice-cold acetone added to the digests was optimized to maximize recoveries of O-glycopeptides...
September 25, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28944671/prioritizing-popular-proteins-in-liver-cancer-remodelling-one-carbon-metabolism
#16
María Isabel Mora, Manuela Molina, Leticia Odriozola, Felix Elortza, Jose M Mato, Barbara Sitek, Pumin Zhang, Fuchu He, Maria Uxue Latasa, Matías Avila, Fernando Corrales
Primary liver cancer (HCC) is recognized as the fifth most common neoplasm and the second leading cause of cancer deaths worldwide. Most risk factors are known and the molecular pathogenesis has been widely studied in the last decade; however, the underlying molecular mechanisms remain to be unveiled, as they will facilitate definition of novel biomarkers and clinical targets for more effective patient management. In this study, we utilize the B/D-HPP popular protein strategy. We report a list of popular proteins that have been highly co-cited with the expression "liver cancer"...
September 25, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28944598/dentition-status-and-frailty-in-community-dwelling-older-adults-a-5-year-prospective-cohort-study
#17
Masanori Iwasaki, Akihiro Yoshihara, Misuzu Sato, Kumiko Minagawa, Mieko Shimada, Mamoru Nishimuta, Toshihiro Ansai, Yutaka Yoshitake, Hideo Miyazaki
AIM: To examine the longitudinal association between dentition status and incidence of frailty in older adults. METHODS: The present prospective cohort study included community-dwelling Japanese adults aged 75 years at baseline (n = 322). Dental examinations, biochemical blood examinations, physical performance and anthropometric measurements, and structured questionnaires were carried out at baseline. The presence of ≥20 teeth with nine or more occluding pairs of teeth was defined as functional dentition...
September 24, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28944502/immune-reconstitution-inflammatory-syndrome-in-non-hiv-immunosuppressed-patients
#18
REVIEW
Hirohiko Sueki, Yoshiko Mizukawa, Yumi Aoyama
Immune reconstitution inflammatory syndrome (IRIS) represents a clinical phenomenon of immune-mediated inflammation against various antigens, including pathogenic microorganisms, drugs and unknown autoantigens, during recovery from immunosuppressed conditions. IRIS has become well recognized in HIV-infected populations. However, IRIS has seldom been recognized in HIV-negative immunocompromised patients. In the last 15 years, the immunopathogenesis of drug-induced hypersensitivity syndrome (DIHS) has been largely determined...
September 25, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28944471/a-composite-of-exhaled-ltb4-lxa4-feno-and-fev1-as-an-asthma-classification-ratio-characterizes-childhood-asthma
#19
Li-Chen Chen, Hsu-Min Tseng, Ming-Ling Kuo, Chih-Yung Chiu, Sui-Ling Liao, Kuan-Wen Su, Ming-Han Tsai, Man-Chin Hua, Shen-Hao Lai, Tsung-Chieh Yao, Kuo-Wei Yeh, Ai-Hsuan Wu, Jing-Long Huang, Shau-Ku Huang
BACKGROUND: Aberrant generation of eicosanoids is associated with asthma, but the evidence remains incomplete and its potential utility as biomarkers is unclear. Major eicosanoids in exhaled breath condensates (EBCs) were assessed as candidate markers for childhood asthma. METHODS: Ten exhaled eicosanoid species was evaluated using ELISA in the discovery phase, followed by prediction model-building and validation phases. RESULTS: Exhaled LTB4 , LTE4 , PGE2 and LXA4 showed significant difference between asthmatics (N=60) and controls (N=20)...
September 25, 2017: Allergy
https://www.readbyqxmd.com/read/28944400/role-of-micrornas-in-doxorubicin-induced-cardiotoxicity-an-overview-of-preclinical-models-and-cancer-patients
#20
REVIEW
Clarissa Ruggeri, Sonia Gioffré, Felice Achilli, Gualtiero I Colombo, Yuri D'Alessandra
Cardiotoxicity is a well-known side effect of doxorubicin (DOX), but the mechanisms leading to this phenomenon are still not completely clear. Prediction of drug-induced dysfunction onset is difficult and is still largely based on detection of cardiac troponin (cTn), a circulating marker of heart damage. In the last years, several investigations focused on the possible involvement of microRNAs (miRNAs) in DOX-induced toxicity in vitro, with contrasting results. Recently, several groups employed animal models to mimic patient's condition, investigate the biological pathways perturbed by DOX, and identify diagnostic markers of cardiotoxicity...
September 25, 2017: Heart Failure Reviews
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