keyword
https://read.qxmd.com/read/38358978/chemo-profiling-of-purpureocillium-lilacinum-and-paecilomyces-variotii-isolates-using-gc-ms-analysis-and-evaluation-of-their-metabolites-against-m-incognita
#21
JOURNAL ARTICLE
Prashant Patidar, Lakshman Prasad, Sushma Sagar, Anil Sirohi, Mahender Singh Saharan, Mukesh Kumar Dhillon, Vaibhav Kumar Singh, Tusar Kanti Bag
Nematophagous fungi are the best alternatives to chemical nematicides for managing nematodes considering environmental health. In the current study, activity of metabolites from ten isolates of Purpureocillium lilacinum (Thom) Luangsa-ard (Hypocreales: Ophiocordycipitaceae) and two isolates of Paecilomyces variotii Bainier (Eurotiales: Trichocomaceae), were examined to inhibit the hatching of Meloidogyne incognita (Kofoid & White) Chitwood (Tylenchida: Heteroderidae) eggs. At 100%, 50%, and 25% concentrations, respectively, the culture filtrate of the isolate P...
2024: PloS One
https://read.qxmd.com/read/38354680/dynamic-changes-at-high-protein-dietary-pattern-of-major-fatty-acids-in-healthy-lactating-women-a-systematic-review-and-meta-analysis
#22
REVIEW
Weixin Liu, Tianyuan Zeng, Abdul Mueed, Baojun Zhang, Teng Wei, Zeyuan Deng, Qinghua Xi
BACKGROUND: Fatty acids (FAs) in human milk are important nutrients for infants. They play important roles in energy supply, nervous system development, and metabolic function maintenance. However, how the composition of major milk FAs change with lactation stages remains controversial. OBJECTIVES: To systematically review the concentration range of major FAs in human milk at various lactation stages. METHODS: A total of 12 papers involving 50 sets of data with 3507 participants were reviewed according to the PRISMA checklist and flow diagram...
January 23, 2024: Nutrition
https://read.qxmd.com/read/38353231/the-assessment-of-the-mechanism-of-action-of-lauric-acid-in-the-context-of-oral-cancer-through-integrative-approach-combining-network-pharmacology-and-molecular-docking-technology
#23
JOURNAL ARTICLE
Kirti Buva, Gauri M Kumbhar, Ajinkya Deshmukh, Vaibhav Sunil Ladke
OBJECTIVES: Lauric acid has been investigated for its effects on various human cancer cell types, although limited research has been dedicated to its impact on oral cancer. In light of this, the objective of our study was to comprehensively assess the anticancer properties of lauric acid specifically in the context of oral cancer. This evaluation was achieved through an in-silico approach, leveraging network analysis techniques. By employing this methodology, we aimed to gain valuable insights into the potential therapeutic benefits of lauric acid for treating oral cancer...
February 5, 2024: Journal of Complementary & Integrative Medicine
https://read.qxmd.com/read/38314578/-ph%C3%A5-nix-dactylifera-l-seed-oil-alleviates-bleomycin-induced-pulmonary-fibrosis-and-oxidative-stress-in-wistar-rats
#24
JOURNAL ARTICLE
Sana Bahri, Raed Abdennabi, Asma Chaker, Afef Nahdi, Amine Elgheryeni, Mona Mlika, Saloua Jameleddine
OBJECTIVE: Idiopathic pulmonary fibrosis (IPF) is the most serious form of interstitial lung disease. We aimed to investigate the effect of Phœnix dactylifera, L. seed oil (DSO) on a murine model of IPF induced by bleomycin (BLM). METHODS: Male Wistar rats were treated with a single intra-tracheal injection of BLM (4 mg/kg) and a daily intraperitoneal injection of DSO (75, 150 and 300 mg/kg) for 4 weeks. RESULTS: Our phytochemical results showed that DSO has an important antioxidant activity with a high content of polyphenols and flavonoids...
February 5, 2024: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/38259870/combined-transcriptome-and-metabolome-analysis-of-sugar-and-fatty-acid-of-aromatic-coconut-and-non-aromatic-coconut-in-china
#25
JOURNAL ARTICLE
Lixia Zhou, Xiwei Sun, Rajesh Yarra, Amjad Iqbal, Qiufei Wu, Jing Li, Yaodong Yang
Sugar and fatty acid content are among the important factors that contribute to the intensity of flavor in aromatic coconut. Gaining a comprehensive understanding of the sugar and fatty acid metabolites in the flesh of aromatic coconuts, along with identifying the key synthetic genes, is of significant importance for improving the development of desirable character traits in these coconuts. However, the related conjoint analysis of metabolic targets and molecular synthesis mechanisms has not been carried out in aromatic coconut until now...
July 30, 2024: Food Chem (Oxf)
https://read.qxmd.com/read/38242387/the-influence-of-short-range-molecular-order-in-gelatinized-starch-on-the-formation-of-starch-lauric-acid-complexes
#26
JOURNAL ARTICLE
Chen Chao, Shiqing Huang, Jinglin Yu, Les Copeland, Yuedong Yang, Shujun Wang
A model system of gelatinized wheat starch (GWS) and lauric acid (LA) was used to examine the effect of residual short-range molecular order in GWS on the formation of starch-lipid complexes. The extent of residual short-range molecular order, as determined by Raman spectroscopy, decreased with increasing water content or heating duration of gelatinization. The enthalpy changes, crystallinity, short-range molecular order and the in vitro enzymic digestion of GWS-LA complexes increased initially to a maximum and then declined as the short-range molecular order in GWS decreased, showing that there was an optimal amount of residual short-range molecular order in GWS for maximizing GWS-LA complexes formation...
January 18, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38237293/synthesis-of-lipophilic-antioxidant-tyrosol-laurate-using-imidazolium-ionic-liquid-bmim-hso-4-as-a-catalyst
#27
JOURNAL ARTICLE
Yimei Wang, Yaoyao Zhang, Xing Qiao, Shangde Sun
Tyrosol is a natural phenolic compound with potent antioxidant properties in the field of food manufacturing. However, the low lipophilicity of tyrosol limited its application. Therefore, the construction of tyrosol laurate (Tyr-L) could effectively overcome the limitations of tyrosol. In this work, four ionic liquids (ILs) were applied for TYr-L preparation. Among them, the 1-butyl-3-methylimidazolium hydrogen sulfate ([Bmim]HSO4 ) showed the best catalytic performance. The maximum TYr-L yield was achieved (94...
January 13, 2024: Food Chemistry
https://read.qxmd.com/read/38211998/-chemical-constituents-of-helleborus-thibetanus
#28
JOURNAL ARTICLE
Yu-Ze Li, Dong-Dong Zhang, Wen-Li Huang, Yi Jiang, Hua-Wei Zhang, Chong Deng, Wei Wang, Jian-Li Liu, Xiao-Mei Song
The chemical constituents of Helleborus thibetanus were isolated and purified by silica gel column chromatography, Sephadex LH-20 gel column chromatography, and semi-preparative RP-HPLC, and the structures of all compounds were identified by modern spectrographic technology(MS, NMR). The MTT method was used to measure the cytotoxicity of compounds 1-8. Twelve compounds were isolated from the roots and rhizomes of H. thibetanus and were identified as(25R)-22β,25-expoxy-26-[(O-β-D-glucopyranosyl)oxy]-1β,3β-dihydroxyfurosta-5-en(1), β-sitosterol myristate(2), β-sitosterol lactate(3), β-sitosterol 3-O-β-D-glucopyrannoside(4), 4,6,8-trihydroxy-3,4-dihydronaphthalen-1(2H)-one(5), 1,3,5-trimethoxybenzene(6), 7,8-dimethylbenzo pteridine-2,4(1H,3H)-dione(7), 1H-indole-3-carboxylic acid(8), p-hydroxy cinnamic acid(9), lauric acid(10), n-butyl α-L-arabinofuranoside(11) and methyl-α-D-fructofuranoside(12), respectively...
December 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/38211596/-in-silico-design-and-development-of-novel-hydroxyurea-lipid-drug-conjugates-for-breast-cancer-therapy-targeting-pi3k-akt-mtor-pathway
#29
JOURNAL ARTICLE
Saranya Dharmaraj, Akey Krishna Swaroop, Mariappan Esakkimuthukumar, Preeya Negi, Selvaraj Jubie
Hydroxyurea (HU) has shown promise in breast cancer treatment, but its hydrophilic nature limits its efficacy. Therefore, conjugating HU with lipids could increase its liphophilicity and improve its cellular uptake, leading to increased efficacy and reduced toxicity. The PI3K/Akt/mTOR pathway is an attractive therapeutic target in cancer not only because it is the second most frequently altered pathway after p53, but also because it serves as a convergence point for many stimuli. The aim of this study is to design and develop novel hydroxyurea lipid drug conjugates for breast cancer therapy targeting the PI3K/Akt/mTOR pathway using in-silico and in-vitro approaches...
January 2024: Drug Research
https://read.qxmd.com/read/38202820/membrane-disruptive-effects-of-fatty-acid-and-monoglyceride-mitigants-on-e-coli-bacteria-derived-tethered-lipid-bilayers
#30
JOURNAL ARTICLE
Sue Woon Tan, Bo Kyeong Yoon, Joshua A Jackman
We report electrochemical impedance spectroscopy measurements to characterize the membrane-disruptive properties of medium-chain fatty acid and monoglyceride mitigants interacting with tethered bilayer lipid membrane (tBLM) platforms composed of E. coli bacterial lipid extracts. The tested mitigants included capric acid (CA) and monocaprin (MC) with 10-carbon long hydrocarbon chains, and lauric acid (LA) and glycerol monolaurate (GML) with 12-carbon long hydrocarbon chains. All four mitigants disrupted E. coli tBLM platforms above their respective critical micelle concentration (CMC) values; however, there were marked differences in the extent of membrane disruption...
January 1, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38201760/regeneration-membranes-loaded-with-non-antibiotic-anti-2-microbials-a-review
#31
REVIEW
Ana Adamuz-Jiménez, Francisco-Javier Manzano-Moreno, Cristina Vallecillo
Both guided bone and guided tissue regeneration are techniques that require the use of barrier membranes. Contamination and infection of the surgical area is one of the most feared complications. Some current lines of research focus on functionalizing these membranes with different antimicrobial agents. The objective of this study was to carry out a review of the use and antibacterial properties of regeneration membranes doped with antimicrobials such as zinc, silver, chlorhexidine, and lauric acid. The protocol was based on PRISMA recommendations, addressing the PICO question: "Do membranes doped with non-antibiotic antimicrobials have antibacterial activity that can reduce or improve infection compared to membranes not impregnated with said antimicrobial?" Methodological quality was evaluated using the RoBDEMAT tool...
December 28, 2023: Polymers
https://read.qxmd.com/read/38201133/synbiotic-glyconutrient-additive-reveals-a-conducive-effect-on-growth-performance-fatty-acid-profile-sensory-characteristics-and-texture-profile-analysis-in-finishing-pig
#32
JOURNAL ARTICLE
Vetriselvi Sampath, Jae Hong Park, In Ho Kim
This study aims to investigate the effect of synbiotic-glyconutrients (SB-GLN) additive on growth performance, fatty acid profile, sensory characteristics, and texture profile analysis in finishing pig. Landrace × Yorkshire ♀ × (Duroc ♂) ( n = 60) pigs with average body weight of 54.88 ± 1 kg were allocated into one of three dietary treatment groups in a complete randomized block design with four replicates of five pigs (two barrows and three gilts) per pen. The test treatments (TRT) were CON-corn-soybean meal basal diet; TRT 1-CON+ 0...
December 28, 2023: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38200899/egg-quality-yolk-fatty-acid-profiles-from-laying-hens-housed-in-conventional-cage-and-cage-free-production-systems-in-the-andean-tropics
#33
JOURNAL ARTICLE
Roy Rodríguez-Hernández, Iang Schroniltgen Rondón-Barragán, Edgar O Oviedo-Rondón
Egg consumers worldwide have increased their concerns about laying hens' welfare and its impact on final egg product quality. This study compared the egg quality parameters under the conventional cage (CC) and cage-free (CF) egg production systems in the tropics. The study was conducted on a commercial farm in Colombia using Hy-Line Brown pullets, reared under the same conditions for the first 15 wks. At 16 wks, the hens were distributed into two housing systems, CC and CF, on the same farm. The hens were fed the same diet for each phase in both systems and feed intake varied slightly...
January 4, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38193700/reduced-graphene-oxide-cellulose-sodium-aerogel-supported-eutectic-phase-change-material-gel-demonstrating-superior-energy-conversion-and-storage-capacity-toward-high-performance-personal-thermal-management
#34
JOURNAL ARTICLE
Hua Su, Pengcheng Lin, Donghai Li, Ying Chen
By virtue of their capacity to absorb and release energy during the phase change process, phase change materials (PCMs) are ideal for personal thermal management (PTM). The combination of reduced graphene oxide/cellulose sodium aerogel (rGCA) and lauric acid/myristic acid binary eutectic phase change gel (LMG) creates a composite phase change material that possesses outstanding photothermal conversion capabilities, electro-thermal conversion capabilities, energy storage capabilities, and shape-stable performance...
January 9, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38193370/exploring-the-potential-of-sago-caterpillars-as-cooking-oils-extraction-purifying-and-characterization
#35
JOURNAL ARTICLE
Feti Fatimah, Sanusi Gugule, Dewa Gede Katja, Audy Denny Wuntu, Stevie Karouw, Jane Sulinda Tambas, Maureen Kumaunang, Chaleb Paul Maanari, Anderson Arnold Aloanis
<b>Background and Objective:</b> The dual demand for palm oil, both as a cooking oil and as a raw material for biodiesel, gives rise to concerns regarding potential shortages. Hence, it is crucial to explore alternative sources of cooking oil, with one such alternative being the oil extracted from sago caterpillars. This study aims to extract and determine the characteristics of sago caterpillar oil and its potential as cooking oil. <b>Materials and Methods:</b> Sago caterpillar oil extraction was done using pressing, Soxhlet extraction and Folch's lipid extraction...
October 2023: Pakistan Journal of Biological Sciences: PJBS
https://read.qxmd.com/read/38191811/liver-acsm3-deficiency-mediates-metabolic-syndrome-via-a-lauric-acid-hnf4%C3%AE-p38-mapk-axis
#36
JOURNAL ARTICLE
Xiao Xiao, Ruofei Li, Bing Cui, Cheng Lv, Yu Zhang, Jun Zheng, Rutai Hui, Yibo Wang
Metabolic syndrome combines major risk factors for cardiovascular disease, making deeper insight into its pathogenesis important. We here explore the mechanistic basis of metabolic syndrome by recruiting an essential patient cohort and performing extensive gene expression profiling. The mitochondrial fatty acid metabolism enzyme acyl-CoA synthetase medium-chain family member 3 (ACSM3) was identified to be significantly lower expressed in the peripheral blood of metabolic syndrome patients. In line, hepatic ACSM3 expression was decreased in mice with metabolic syndrome...
January 8, 2024: EMBO Journal
https://read.qxmd.com/read/38188981/study-on-anionic-nonionic-mixed-surfactant-for-enhanced-oil-recovery-in-a-hypersaline-reservoir
#37
JOURNAL ARTICLE
Luxuan Ma, Ping Xu, Lei Wang, Kai Xia, Hui Du, Ruitong Gao, Zhaojun Chen
Hypersaline reservoirs are characterized by high salinity and high calcium and magnesium concentration. In order to enhance oil recovery of the hypersaline reservoirs, a specialized ternary mixed surfactant system composed of nonionic alkanolamide surfactants and anionic surfactant was developed in this study. Through careful analysis and optimization, lauric acid diethanolamide (LDEA), octanoic acid diethanolamide (ODEA), and sodium dodecyl sulfonate (SDS) were identified as promising candidates for the surfactant compounding system, and formed a ternary surfactant system composed of LDEA, ODEA, and SDS with the mass ratio of 4...
January 2, 2024: RSC Advances
https://read.qxmd.com/read/38171727/binding-interaction-between-lauric-acid-and-cluster-of-differentiation-36-underpinned-by-a-fluorescence-intensifying-assay
#38
JOURNAL ARTICLE
Satoshi Tsuzuki, Tatsuya Sugawara, Yuki Manabe, Masayuki Yamasaki, Tsutomu Sasaki
Cluster of differentiation 36 (CD36) is a scavenger receptor expressed in various vertebrate cells that contains diverse ligands, including long-chain fatty acids. This receptor has recently been suggested as a captor of specific volatile odorants (e.g., aliphatic acetates) in the mammalian nasal epithelium. This study used a fluorescence-intensifying assay to produce the first evidence that lauric acid, an odorous fatty acid, directly binds to CD36. This expansion of the repertoire of volatile ligands supports potential applications for nasal CD36...
2024: Journal of Oleo Science
https://read.qxmd.com/read/38166588/lauric-acid-attenuates-hepato-metabolic-complications-and-molecular-alterations-in-high-fat-diet-induced-nonalcoholic-fatty-liver-disease-in-rats
#39
JOURNAL ARTICLE
Ahmed A Sedik, Rania Elgohary, Eman Khalifa, Wagdy K B Khalil, Heba I Shafey, Mohamed B Shalaby, Mona S O Gouida, Yasmin M Tag
Nonalcoholic fatty liver disease (NAFLD) has emerged as a major chronic liver illness characterized by increase of lipid content in the liver. This study investigated the role of lauric acid to treat NAFLD in male adult Sprague Dawley rats. In this study, to induce NAFLD in the rats, a high-fat diet (HFD) was administered for eight consecutive weeks. Lauric acid groups received lauric acid (250 and 500 mg/kg; orally), concurrently with HFD for eight consecutive weeks. Lauric acid could ameliorate the serum levels of TG, TC, ALT, AST, blood glucose, and insulin...
January 2, 2024: Toxicology Mechanisms and Methods
https://read.qxmd.com/read/38165986/gas-chromatography-mass-spectrometry-analysis-of-fatty-acids-in-healthy-and-aspergillus-niger-mh078571-1-infected-arabica-coffee-beans
#40
JOURNAL ARTICLE
Amira H Alabdalall
The organic composition of Arabica coffee beans, particularly fatty acids, significantly influences their overall quality. After measuring its composition of fatty acids, it contained a high percentage of saturated fatty acids (SFA), including caprylic, lauric, myristic, palmitic, margaric, fat, and orchid. Moreover, the sample contained unsaturated fatty acids (USFA), namely palmitoleic acid (C16:1), oleic acid (C18:1), linoleic acid (C18:2), and alpha-linoleic acid (C18:3). Coffee beans are susceptible to infection by fungi during storage, the development of which has adverse effects on the beans...
2024: PloS One
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