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https://www.readbyqxmd.com/read/29752124/fabrication-of-hyaluronidase-responsive-biocompatible-multilayers-on-bmp2-loaded-titanium-nanotube-for-the-bacterial-infection-prevention
#1
Linawati Sutrisno, Yan Hu, Xinkun Shen, Menghuan Li, Zhong Luo, Liangliang Dai, Sixiang Wang, Julia Li Zhong, Kaiyong Cai
Infection associated with orthopedic implants is the chief cause of implant failure. An important consideration to prevent the infection at implants is to inhibit the biofilm formation for the initial 6 h. Therefore, we fabricated hyaluronidase-sensitive multilayers of chitosan (Chi)/sodium hyaluronate-lauric acid (SL) onto the surface of bone morphogenetic protein 2 (BMP2) loaded titanium nanotube (TNT) via spin-assisted layer-by-layer technique. The results of both Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (1 H NMR) confirmed the successful synthesis of SL...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29739955/surface-modification-of-spions-in-phbv-microspheres-for-biomedical-applications
#2
Maizlinda I Idris, Jan Zaloga, Rainer Detsch, Judith A Roether, Harald Unterweger, Christoph Alexiou, Aldo R Boccaccini
Surface modification of superparamagnetic iron oxide nanoparticles (SPIONs) has been introduced with lauric acid and oleic acid via co-precipitation and thermal decomposition methods, respectively. This modification is required to increase the stability of SPIONs when incorporated in hydrophobic, biodegradable and biocompatible polymers such as poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). In this work, the solid-in-oil-in-water (S/O/W) emulsion-solvent extraction/evaporation method was utilized to fabricate magnetic polymer microspheres incorporating SPIONs in PHBV...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29738980/employing-metabolic-engineered-lipolytic-microbial-platform-for-1-alkene-one-step-conversion
#3
Juli Wang, Haiying Yu, Kun Zhu
1-Alkenes are traditionally used as basic chemicals with great importance. Biosynthetic 1-alkenes also have the potential to serve as biofuels. In this study, we engineered a Pseudomonas lipolytic microbial platform for 1-alkene production using hydrophobic substrate as sole carbon source. Fatty acid decarboxylase UndA and UndB were cloned and expressed, which successfully produced 1-alkenes. Optimal culturing temperature and the interruption of competitive pathway were proven to be beneficial to 1-alkene synthesis...
May 1, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29729699/effects-of-climate-on-fatty-acid-profile-in-camelina-sativa
#4
Zahra Raziei, Danial Kahrizi, Hosein Rostami-Ahmadvandi
Due to the importance of Camelina for low expectation (water and other inputs) and as an oil crop, Soheil cultivar was cultivated in Ardebil, Hamedan, Rasht, Ilam, Kermanshah, Karaj, Mashhad, Ahvaz and Bushehr Provinces. Fatty acids were measured with MG-Mass. Results showed that morphological traits were not very dependent on the climate, but the profile of the fatty acids was dependent. ANOVA of the effects of climate on the saturated fatty acid showed that there were significant differences between climates for all studied SFAs (P<0...
April 30, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29727961/pyrethroid-insecticide-lambda-cyhalothrin-induces-hepatic-cytochrome-p450-enzymes-oxidative-stress-and-apoptosis-in-rats
#5
María-Aránzazu Martínez, Irma Ares, José-Luis Rodríguez, Marta Martínez, David Roura-Martínez, Victor Castellano, Bernardo Lopez-Torres, María-Rosa Martínez-Larrañaga, Arturo Anadón
This study aimed to examine in rats the effects of the Type II pyrethroid lambda-cyhalothrin on hepatic microsomal cytochrome P450 (CYP) isoform activities, oxidative stress markers, gene expression of proinflammatory, oxidative stress and apoptosis mediators, and CYP isoform gene expression and metabolism phase I enzyme PCR array analysis. Lambda-cyhalothrin, at oral doses of 1, 2, 4 and 8mg/kg bw for 6days, increased, in a dose-dependent manner, hepatic activities of ethoxyresorufin O-deethylase (CYP1A1), methoxyresorufin O-demethylase (CYP1A2), pentoxyresorufin O-depentylase (CYP2B1/2), testosterone 7α- (CYP2A1), 16β- (CYP2B1), and 6β-hydroxylase (CYP3A1/2), and lauric acid 11- and 12-hydroxylase (CYP4A1/2)...
August 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29727512/comprehending-the-influence-of-critical-cultivation-parameters-on-the-oleaginous-behavior-of-potent-rotten-fruit-yeast-isolates
#6
Batul Diwan, Pratima Gupta
AIMS: Oleaginous yeasts were isolated from five different rotten fruits and their oleaginous behaviour was characterized with varying carbon source and concentration (C/N) to pave the path for their future applicabilities. METHODS & RESULTS: Sixteen yeasts were isolated, those accumulating around 20% of their cell dry weights as lipids were screened out and identified as Candida tropicalis and Pichia kudriavzevii. Amongst glucose, maltose, and sucrose, glucose was found favorable carbon source in terms of biomass yield and lipid content...
May 4, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29713567/palmitic-acid-induces-neurotoxicity-and-gliatoxicity-in-sh-sy5y-human-neuroblastoma-and-t98g-human-glioblastoma-cells
#7
Yee-Wen Ng, Yee-How Say
Background: Obesity-related central nervous system (CNS) pathologies like neuroinflammation and reactive gliosis are associated with high-fat diet (HFD) related elevation of saturated fatty acids like palmitic acid (PA) in neurons and astrocytes of the brain. Methods: Human neuroblastoma cells SH-SY5Y (as a neuronal model) and human glioblastoma cells T98G (as an astrocytic model), were treated with 100-500 µM PA, oleic acid (OA) or lauric acid (LA) for 24 h or 48 h, and their cell viability was assessed by 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay...
2018: PeerJ
https://www.readbyqxmd.com/read/29680605/effects-of-ultrasonic-treatment-on-amylose-lipid-complex-formation-and-properties-of-sweet-potato-starch-based-films
#8
Pengfei Liu, Rui Wang, Xuemin Kang, Bo Cui, Bin Yu
To investigate the effect of ultrasonic treatment on the properties of sweet potato starch and sweet potato starch-based films, the complexing index, thermograms and diffractograms of the sweet potato starch-lauric acid composite were tested, and light transmission, microstructure, and mechanical and moisture barrier properties of the films were measured. The results indicated that the low power density ultrasound was beneficial to the formation of an inclusion complex. In thermograms, the gelatinization enthalpies of the ultrasonically treated starches were lower than those of the untreated sample...
June 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29677105/the-chemical-composition-and-metabolic-effects-of-attalea-phalerata-nut-oil-in-hyperlipidemic-rats-induced-by-a-high-fructose-diet
#9
Débora da Silva Baldivia, Eliana Janet Sanjinez-Argandonã, Kátia Ávila Antunes, Izabel Cristina Freitas Moraes, Edson Lucas Dos Santos, Kely de Picoli Souza
The fatty acids found in nuts are important regulators of the metabolism. These acids are frequently associated with a reduction of serum cholesterol and body fat and a lower risk of developing cardiovascular disease. In this context, the aim of this study was to identify and quantify the nut oil fatty acids from Attalea phalerata and investigate their metabolic effects in rats with hyperlipidemia induced by a diet rich in fructose. Oleic and lauric acids were the major compounds found in the A. phalerata nut oil (APNO)...
April 20, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29667445/the-mechanism-of-lauric-acid-modified-protein-nanocapsules-escape-from-intercellular-trafficking-vesicles-and-its-implication-for-drug-delivery
#10
Lijuan Jiang, Xin Liang, Gan Liu, Yun Zhou, Xinyu Ye, Xiuli Chen, Qianwei Miao, Li Gao, Xudong Zhang, Lin Mei
Protein nanocapsules have exhibited promising potential applications in the field of protein drug delivery. A major issue with various promising nano-sized biotherapeutics including protein nanocapsules is that owing to their particle size they are subject to cellular uptake via endocytosis, and become entrapped and then degraded within endolysosomes, which can significantly impair their therapeutic efficacy. In addition, many nano-sized biotherapeutics could be also sequestered by autophagosomes and degraded through the autolysosomal pathway...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29644551/lipase-catalyzed-epoxidation-of-fatty-acid-methyl-esters-derived-from-unsaturated-vegetable-oils-in-absence-of-carboxylic-acid
#11
Alejandro Sustaita-Rodríguez, Víctor H Ramos-Sánchez, Alejandro A Camacho-Dávila, Gerardo Zaragoza-Galán, José C Espinoza-Hicks, David Chávez-Flores
Nowadays the industrial chemistry reactions rely on green technologies. Enzymes as lipases are increasing its use in diverse chemical processes. Epoxidized fatty acid methyl esters obtained from transesterification of vegetable oils have recently found applications as polymer plasticizer, agrochemical, cosmetics, pharmaceuticals and food additives. In this research article, grapeseed, avocado and olive oils naturally containing high percents of mono and poly unsaturations were used as starting materials for the production of unsaturated fatty acid methyl esters...
April 11, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29623233/hydrolysis-activity-of-virgin-coconut-oil-using-lipase-from-different-sources
#12
T A V Nguyen, Truong D Le, Hoa N Phan, Lam B Tran
Two types of lipase, Candida rugosa lipase (CRL) and porcine pancreas lipase (PPL), were used to hydrolyze virgin coconut oil (VCO). The hydrolysis process was carried out under four parameters, VCO to buffer ratio, lipase concentration, pH, and temperature, which have a significant effect on hydrolysis of lipase. CRL obtained the best hydrolysis condition at 1 : 5 of VCO to buffer ratio, 1.5% of CRL concentration, pH 7, and temperature of 40°C. Meanwhile, PPL gave different results at 1 : 4 of VCO to buffer ratio, 2% of lipase concentration, pH 7...
2018: Scientifica
https://www.readbyqxmd.com/read/29608856/formulation-and-stabilization-of-concentrated-edible-oil-in-water-emulsions-based-on-electrostatic-complexes-of-a-food-grade-cationic-surfactant-ethyl-lauroyl-arginate-and-cellulose-nanocrystals
#13
Long Bai, Wenchao Xiang, Siqi Huan, Orlando J Rojas
We report on high internal phase ratio, oil-in-water Pickering emulsions that are stable against coalescence during storage. For this, viscous, edible oil (sunflower) was emulsified in the presence of naturally-derived cellulose nanocrystals (CNC) and a food-grade, bio-based cationic surfactant obtained from lauric acid and L-arginine (ethyl lauroyl arginate, LAE). The interactions between CNC and LAE were elucidated by isothermal titration calorimetry (ITC) and supplementary techniques. LAE adsorption on CNC surfaces and its effect on nanoparticle electrostatic stabilization, aggregation state, and emulsifying ability were studied and related to the properties of resultant oil-in-water emulsions...
April 2, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29601143/synthetic-%C3%AE-mangostin-dilaurate-strongly-suppresses-wide-spectrum-organ-metastasis-in-a-mouse-model-of-mammary-cancer
#14
Masa-Aki Shibata, Hitomi Hamaoka, Junji Morimoto, Tadashi Kanayama, Kentaro Maemura, Yuko Ito, Munekazu Iinuma, Yoichi Kondo
We previously reported that, in a mouse model of mammary cancer, α-mangostin alone exhibits anti-metastatic properties. To enhance this anti-metastatic effect, we examined the efficacy of synthetic α-mangostin dilaurate (MGD), prepared by adding lauric acid to α-mangostin, in the same experimental system wherein mice bearing mammary tumors are exposed to dietary MGD at 0, 2000, and 4000 ppm. Lauric acid has a high propensity for lymphatic absorbtion, which is the most common pathway of initial dissemination of many solid malignancies...
March 30, 2018: Cancer Science
https://www.readbyqxmd.com/read/29599640/the-effects-of-4-hydroxybenzoic-acid-identified-from-bamboo-dendrocalamus-asper-shoots-on-kv1-4-channel
#15
Jingli Zhang, Fatin H Mohamad, Jia Hui Wong, Habsah Mohamad, Abdul Hadi Ismail, Abdul Aziz Mohamed Yusoff, Hasnah Osman, Kok Tong Wong, Zamzuri Idris, Jafri Malin Abdullah
Background: Bamboo shoot has been used as a treatment for epilepsy in traditional Chinese medicine for generations to treat neuronal disorders such as convulsive, dizziness and headaches. 4-hydroxybenzoic acid (4-hba) is a non-flavonoid phenol found abundantly in Dendrocalamus asper shoots (bamboo), fruits (strawberries and apples) and flowers. Kv1.4 is a rapidly inactivating Shaker -related member of the voltage-gated potassium channels with two inactivation mechanisms; the fast N-type and slow C-type...
February 2018: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/29584655/performance-of-different-immobilized-lipases-in-the-syntheses-of-short-and-long-chain-carboxylic-acid-esters-by-esterification-reactions-in-organic-media
#16
Lionete Nunes de Lima, Adriano Aguiar Mendes, Roberto Fernandez-Lafuente, Paulo Waldir Tardioli, Raquel de Lima Camargo Giordano
Short-chain alkyl esters and sugar esters are widely used in the food, pharmaceutical and cosmetic industries due to their flavor and emulsifying characteristics, respectively. Both compounds can be synthesized via biocatalysis using lipases. This work aims to compare the performance of commercial lipases covalently attached to dry acrylic beads functionalized with oxirane groups (lipases from Candida antarctica type B-IMMCALB-T2-350, Pseudomonas fluorescens -IMMAPF-T2-150, and Thermomyces lanuginosus -IMMTLL-T2-150) and a home-made biocatalyst (lipase from Pseudomonas fluorescens adsorbed onto silica coated with octyl groups, named PFL-octyl-silica) in the syntheses of short- and long-chain carboxylic acid esters...
March 27, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29526877/preparation-of-copper-ii-containing-phosphomolybdic-acid-salt-as-catalyst-for-the-synthesis-of-biodiesel-by-esterification
#17
Jie Cai, Qiu-Yun Zhang, Fang-Fang Wei, Jin-Shu Huang, Yun-Mei Feng, Hai-Tao Ma, Yutao- Zhang
Copper (II) containing phosphomolybdic acid (PMA) catalysts were synthesized by ion exchange method and characterization using various physico-chemical techniques such as X-ray diffraction (XRD), fourier transform infrared spectroscopy (FT-IR), thermogravimetric (TG) and scanning electron microscopy (SEM). The characterization results showed that the Keggin ions were retained in the catalysts and possessed well thermal stability. The catalytic esterification of lauric acid with methanol could be easily achieved about 78...
April 1, 2018: Journal of Oleo Science
https://www.readbyqxmd.com/read/29526089/fatty-acid-profile-and-the-sn-2-position-distribution-in-triacylglycerols-of-breast-milk-during-different-lactation-stages
#18
Ce Qi, Jin Sun, Yuan Xia, Renqiang Yu, Wei Wei, Jingying Xiang, Qingzhe Jin, Hang Xiao, Xingguo Wang
Fatty acid (FA) is the major energy resource in breast milk, which is important for infant development. FAs profiles with sn-2 positional preference were an important part of triacylglycerols due to their better availability. This profile is still not replicated in artificial formulas. This study quantified the FAs profile of total and sn-2 position in human breast milk samples from 103 healthy volunteers during colostrum, transitional, and mature stages. Multicomponent analysis showed significant differences in FAs profiles of different lactation periods, due to that with relative percentage less than 1%...
March 28, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29524001/intake-of-dietary-saturated-fatty-acids-and-risk-of-type-2-diabetes-in-the-european-prospective-investigation-into-cancer-and-nutrition-netherlands-cohort-associations-by-types-sources-of-fatty-acids-and-substitution-by-macronutrients
#19
Shengxin Liu, Yvonne T van der Schouw, Sabita S Soedamah-Muthu, Annemieke M W Spijkerman, Ivonne Sluijs
PURPOSE: The association between dietary saturated fatty acids (SFA) intake and type 2 diabetes (T2D) remains unclear. This study aimed at investigating the association between SFA intake and T2D risk based on (1) individual SFA (differing in carbon chain length), (2) food sources of SFA and (3) the substituting macronutrients. METHODS: 37,421 participants from the European Prospective Investigation into Cancer and Nutrition-Netherlands (EPIC-NL) cohort were included in this study...
March 9, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29518466/peg-pga-enveloped-octaarginine-peptide-nanocomplexes-an-oral-peptide-delivery-strategy
#20
Zhigao Niu, Eleni Samaridou, Emilie Jaumain, Julie Coëne, Gabriela Ullio, Neha Shrestha, Josep Garcia, Matilde Durán-Lobato, Sulay Tovar, Manuel J Santander-Ortega, M Victoria Lozano, M Mar Arroyo-Jimenez, Rocío Ramos-Membrive, Iván Peñuelas, Aloïse Mabondzo, Véronique Préat, Meritxell Teixidó, Ernest Giralt, María José Alonso
The objective of this work was the development of a new drug nanocarrier intended to overcome the barriers associated to the oral modality of administration and to assess its value for the systemic or local delivery of peptides. The nanocarrier was rationally designed taking into account the nature of the intestinal barriers and was loaded with insulin, which was selected as a model peptide. The nanocarrier consisted of a complex between insulin and a hydrophobically-modified cell penetrating peptide (CPP), enveloped by a protecting polymer...
April 28, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
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