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lauric acid

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https://www.readbyqxmd.com/read/28718686/kinetic-study-on-the-inhibition-of-xanthine-oxidase-by-acylated-derivatives-of-flavonoids-synthesised-enzymatically
#1
Maria Elisa Melo Branco de Araújo, Yollanda Edwirges Moreira Franco, Thiago Grando Alberto, Marcia Cristina Fernandes Messias, Camila Wielewski Leme, Alexandra Christine Helena Frankland Sawaya, Patricia de Oliveira Carvalho
Studies have reported that flavonoids inhibit xanthine oxidase (XO) activity; however, poor solubility and stability in lipophilic media limit their bioavailability and applications. This study evaluated the kinetic parameters of XO inhibition and partition coefficients of flavonoid esters biosynthesised from hesperidin, naringin, and rutin via enzymatic acylation with hexanoic, octanoic, decanoic, lauric, and oleic acids catalysed by Candida antarctica lipase B (CALB). Quantitative determination by ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) showed higher conversion yields (%) for naringin and rutin esters using acyl donors with 8C and 10C...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28693220/remodeling-of-energy-metabolism-by-a-ketone-body-and-medium-chain-fatty-acid-suppressed-the-proliferation-of-ct26-mouse-colon-cancer-cells
#2
Yui Kadochi, Shiori Mori, Rina Fujiwara-Tani, Yi Luo, Yukiko Nishiguchi, Shingo Kishi, Kiyomu Fujii, Hitoshi Ohmori, Hiroki Kuniyasu
Normal and cancerous cells are suggested to have differential utilization of fatty acids and ketone bodies, which could be exploited in cancer therapy. The present study examined the effect of 3-hydroxybutyric acid (3-HBA), which is a ketone body generating acetyl-CoA, and lauric acid (LAA, C12:0), which is a medium-chain saturated fatty acid translocated to mitochondria in a carnitine-independent manner to produce acetyl-CoA, on the energy metabolism of mouse CT26 colon cancer cells. In CT26 cells expressing 3-HBA and LAA transporters, 3-HBA and LAA reduced cell proliferation, mitochondrial volume and lactate production, and increased oxidative stress, particularly in low-glucose conditions...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28691884/synergistic-antimicrobial-combinations-inhibit-and-inactivate-listeria-monocytogenes-in-neutral-and-acidic-broth-systems
#3
Sarah M Kozak, Kyle M Margison, Dennis J D'amico
The use of antimicrobial compounds can be an effective approach to control Listeria monocytogenes in ready-to-eat foods, but it can also be limited by cost, restrictions on concentrations in foods, and potential changes to organoleptic properties. Combinatorial approaches that produce additive or synergistic effects allow for reductions in individual antimicrobial concentrations while achieving the same level of control. The present study determined the MIC and MBC of an antimicrobial compound when used alone or in binary combinations against L...
July 10, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28660089/does-inhalation-of-virgin-coconut-oil-accelerate-reversal-of-airway-remodelling-in-an-allergic-model-of-asthma
#4
N A Kamalaldin, S A Sulaiman, M R Yusop, B Yahaya
Many studies have been done to evaluate the effect of various natural products in controlling asthma symptoms. Virgin coconut oil (VCO) is known to contain active compounds that have beneficial effects on human health and diseases. The objective of this study was to evaluate the effect of VCO inhalation on airway remodelling in a rabbit model of allergic asthma. The effects of VCO inhalation on infiltration of airway inflammatory cells, airway structures, goblet cell hyperplasia, and cell proliferation following ovalbumin induction were evaluated...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28639182/differential-interaction-of-myoglobin-with-select-fatty-acids-of-carbon-chain-lengths-c8-to-c16
#5
Thomas Jue, Lifan Shih, Youngran Chung
Previous studies have shown that palmitic acid (PAM) and oleic acid (OLE) can bind myoglobin (Mb). How fatty acids (FA) with different carbon chain lengths and sulfate substitution interact with Mb remains uncertain. Indeed, C8:0 and C10:0 fatty acids do not perturb the intensities of the (1)H-NMR MbCN signal intensity at FA:Mb ratios below 2:1. Starting with C12:0, C12:0-C16:0, FA induce a noticeable spectral change. C12:0 and C14:0 FA affect both the 5- and 8-heme methyl signals, whereas the C16:0 FA perturbs only the 8-heme methyl signal...
June 21, 2017: Lipids
https://www.readbyqxmd.com/read/28635367/in-vivo-and-in-vitro-depolymerizations-of-intracellular-medium-chain-length-poly-3-hydroxyalkanoates-produced-by-pseudomonas-putida-bet001
#6
Siti Nor Syairah Anis, Mohamad Suffian Mohamad Annuar, Khanom Simarani
In vivo and in vitro depolymerizations of intracellular medium-chain-length poly-3-hydroxyalkanoates (mcl-PHA) in Pseudomonas putida Bet001 grown on lauric acid was studied. Both processes were studied under optimum conditions for mcl-PHA depolymerization viz. 0.2 M Tris-HCl buffer, pH 9, ionic strength (I) = 0.2 M at 30 °C. For in vitro depolymerization studies, cell-free system was obtained from lysing bacterial cells suspension by ultrasonication at optimum conditions (frequency 37 kHz, 30% of power output, <25 (°)C for 120 minutes)...
June 21, 2017: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/28627009/iron-catalyzed-radical-decarboxylative-oxyalkylation-of-terminal-alkynes-with-alkyl-peroxides
#7
Xiaotao Zhu, Changqing Ye, Yajun Li, Hongli Bao
We report an iron-catalyzed oxyalkylation of alkynes with alkyl peroxides as the alkylating reagents. Alkyl peroxides are readily available from aliphatic acids and serve simultaneously as the alkylating reagents and internal oxidants. Primary, secondary, and tertiary alkyl groups of aliphatic acids were readily incorporated into C-C triple bonds and diverse α-alkylated ketones were synthesized. Mechanism studies revealed that this reaction involves highly reactive alkyl free radicals. A unique equilibrium between lauric acid and water catalyzed by the iron(III) catalyst was observed...
June 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28617858/effect-of-three-edible-oils-on-the-intestinal-absorption-of-caffeic-acid-an-in-vivo-and-in-vitro-study
#8
W Chaturi Prasadani, Chaturi M Senanayake, Nimanthi Jayathilaka, Sagarika Ekanayake, Kapila N Seneviratne
Polyphenolic antioxidants are mainly absorbed through passive paracellular permeation regulated by tight junctions. Some fatty acids are known to modulate tight junctions. Fatty acids resulting from the digestion of edible oils may improve the absorption of polyphenolic antioxidants. Therefore, we explored the effect of three edible oils on the intestinal absorption of caffeic acid. Rats were fed with soybean oil and caffeic acid dissolved in distilled water. Caffeic acid contents in the plasma collected up to 1 hr were quantified...
2017: PloS One
https://www.readbyqxmd.com/read/28615134/synthesis-and-biological-evaluation-of-5-fatty-acylamido-1-3-4-thiadiazole-2-thioglycosides
#9
Srikanth Vudhgiri, Dhevendar Koude, Dileep Kumar Veeragoni, Sunil Misra, R B N Prasad, Ram Chandra Reddy Jala
In the present study, the synthesis of 1, 3, 4-thiadiazole-based thioglycosides were accomplished in good yields with employing a convergent synthetic route. The starting material 5-amino-1, 3, 4-thiadiazole-2-thiol and followed by a series of 5-fatty-acylamido-1, 3, 4-thiadiazole-2-thiols (4a-4j) were synthesized with different fatty acid chlorides. The glycosylation of compounds 4a-4j were achieved with trichloroacetimidate methodology. Antimicrobial and cytotoxicity activities of title compounds were evaluated...
August 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28593370/identification-of-optimum-fatty-acid-extraction-methods-for-two-different-microalgae-phaeodactylum-tricornutum-and-haematococcus-pluvialis-for-food-and-biodiesel-applications
#10
Paz Otero, Sushanta Kumar Saha, Joanne Mc Gushin, Siobhan Moane, John Barron, Patrick Murray
Microalgae have the potential to synthesize and accumulate lipids which contain high value fatty acids intended for nutrition and biodiesel applications. Nevertheless, lipid extraction methods for microalgae cells are not well established and there is not a standard analytical methodology to extract fatty acids from lipid-producing microalgae. In this paper, current lipid extraction procedures employing organic solvents (chloroform/methanol, 2:1 and 1:2, v/v), sodium hypochlorite solution (NaClO), acid-catalysed hot-water extraction and the saponification process [2...
June 7, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28551247/identification-and-quantitative-analysis-of-%C3%AE-cryptoxanthin-and-%C3%AE-citraurin-esters-in-satsuma-mandarin-fruit-during-the-ripening-process
#11
Gang Ma, Lancui Zhang, Kohei Iida, Yuki Madono, Witchulada Yungyuen, Masaki Yahata, Kazuki Yamawaki, Masaya Kato
In this study, to investigate the xanthophyll accumulation in citrus fruits, the major fatty acid esters of β-cryptoxanthin and β-citraurin were identified, and changes in their contents were investigated in two Satsuma mandarin varieties, 'Miyagawa-wase' and 'Yamashitabeni-wase', during the ripening process. The results showed that β-cryptoxanthin and β-citraurin were mainly esterified with lauric acid, myristic acid, and palmitic acid in citrus fruits. During the ripening process, β-cryptoxanthin laurate, myristate, and palmitate were accumulated gradually in the flavedos and juice sacs of the two varieties...
November 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28550989/biosynthesis-of-medium-chain-length-alkanes-for-bio-aviation-fuel-by-metabolic-engineered-escherichia-coli
#12
Meng Wang, Kaili Nie, Hao Cao, Haijun Xu, Yunming Fang, Tianwei Tan, Jan Baeyens, Luo Liu
The aim of this work was to study the synthesis of medium-chain length alkanes (MCLA), as bio-aviation product. To control the chain length of alkanes and increase the production of MCLA, Escherichia coli cells were engineered by incorporating (i) a chain length specific thioesterase from Umbellularia californica (UC), (ii) a plant origin acyl carrier protein (ACP) gene and (iii) the whole fatty acid synthesis system (FASs) from Jatropha curcas (JC). The genetic combination was designed to control the product spectrum towards optimum MCLA...
September 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28526391/withdrawal-from-high-carbohydrate-high-saturated-fat-diet-changes-saturated-fat-distribution-and-improves-hepatic-low-density-lipoprotein-receptor-expression-to-ameliorate-metabolic-syndrome-in-rats
#13
Ankita Hazarika, Himadri Kalita, Mohan Chandra Kalita, Rajlakshmi Devi
OBJECTIVE: The "lipid hypothesis" determined that saturated fatty acid (SFA) raises low-density lipoprotein cholesterol, thereby increasing the risk for metabolic syndrome (MetS). The aim of this study was to investigate the effect of subchronic withdrawal from a high-carbohydrate, high-saturated fat (HCHF) diet during MetS with reference to changes in deleterious SFA (C12:0, lauric acid; C14:0, myristic acid; C16:0, palmitic acid; C18:0, stearic acid) distribution in liver, white adipose tissue (WAT), and feces...
June 2017: Nutrition
https://www.readbyqxmd.com/read/28480436/studies-on-chemical-composition-and-antimicrobial-activities-of-bioactive-molecules-from-date-palm-phoenixdactylifera-l-pollens-and-seeds
#14
Najla Bentrad, Rabéa Gaceb-Terrak, Yamina Benmalek, Fatma Rahmania
BACKGROUND: Natural resources have been the crucial origin of chemical elements. They have been used in many traditions as alternative medicines. The chemical profiling of some plant extracts and essential oils related to different plants were followed to unveil their most active components. In this paper, Phoenix dactilyfera L was selected as a host plant to investigate the composition of different organs with different cultivars. MATERIALS AND METHOD: The antibacterial and antifungal activities of the extracts have been tested using different techniques, including optical density and GC/MS analyses of the natural extracts...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28465608/depot-specific-differences-in-fatty-acid-composition-and-distinct-associations-with-lipogenic-gene-expression-in-abdominal-adipose-tissue-of-obese-women
#15
P Petrus, D Edholm, F Rosqvist, I Dahlman, M Sundbom, P Arner, M Rydén, U Risérus
Cardiometabolic diseases are primarily linked to enlarged visceral adipose tissue (VAT). However, some data suggest heterogeneity within the subcutaneous adipose tissue (SAT) depot with potential metabolic differences between the superficial SAT (sSAT) and deep SAT (dSAT) compartments. We aimed to investigate the heterogeneity of these three depots with regard to fatty acid (FA) composition and gene expression. Adipose tissue biopsies were collected from 75 obese women undergoing laparoscopic gastric bypass surgery...
May 3, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28462183/antibacterial-efficacy-of-tender-coconut-water-cocos-nucifera-l-on-streptococcus-mutans-an-in-vitro-study
#16
J N Rukmini, Sunkari Manasa, Chenna Rohini, Lavanya Putchla Sireesha, Sachan Ritu, G K Umashankar
OBJECTIVE: The antibacterial property of coconut, the presence of lauric acid, and the ability to extract antimicrobial peptides Cn-AMP (1, 2, and 3) from tender coconut water has drawn attention on its effectiveness in normal consumption. An in-vitro experimental study was conducted to evaluate the antimicrobial efficacy of tender coconut water in its natural state on Streptococcus mutans. MATERIALS AND METHODS: Fresh tender coconut water and pasteurized tender coconut water were taken as test samples, dimethyl formamide was used as the negative control, and 0...
March 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28459517/effect-of-fanbaicao-herba-potentillae-discoloris-oil-on-the-expression-of-p21-and-cdk4-in-hepg2-cells
#17
Lei Liu, Guang Chen, Baixin Wang, Liping Chen, Shuqiu Wang, Zhixin Liu, Xiaoru Ma, Fangfang Wang, Yanfeng Liang, Jiamei Wu, Zhiwei Yang
OBJECTIVE: To research the anti-cancer mechanism of the Traditional Chinese Medicine Fanbaicao (Herba Potentillae Discoloris) oil in the human hepatoma cell line HepG2. METHODS: Gas chromatography was used to analyze the components of Fanbaicao (Herba Potentillae Discoloris). We tested the inhibitory effect of Fanbaicao (Herba Potentillae Discoloris) oil on the human hepatoma cell line HepG2 in vitro using 3-(4, 5-Dimet hylt hiazol-2-yl)-2,5-dip henyltetrazolium bromide assays...
August 2016: Journal of Traditional Chinese Medicine, Chung i Tsa Chih Ying Wen Pan
https://www.readbyqxmd.com/read/28458541/selection-of-potential-iron-oxide-nanoparticles-for-breast-cancer-treatment-based-on-in-vitro-cytotoxicity-and-cellular-uptake
#18
Johanna M Poller, Jan Zaloga, Eveline Schreiber, Harald Unterweger, Christina Janko, Patricia Radon, Dietmar Eberbeck, Lutz Trahms, Christoph Alexiou, Ralf P Friedrich
Superparamagnetic iron oxide nanoparticles (SPIONs) are promising tools for the treatment of different diseases. Their magnetic properties enable therapies involving magnetic drug targeting (MDT), hyperthermia or imaging. Depending on the intended treatment, specific characteristics of SPIONs are required. While particles used for imaging should circulate for extended periods of time in the vascular system, SPIONs intended for MDT or hyperthermia should be accumulated in the target area to come into close proximity of, or to be incorporated into, specific tumor cells...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28453979/effects-of-replacement-of-beef-fat-with-interesterified-palm-kernel-oil-on-the-quality-characteristics-of-turkish-dry-fermented-sausage
#19
Birol Kılıç, Cem Okan Özer
The objective of this study was to investigate the effects of replacing beef fat with enzymatic interesterified palm kernel oil (IPKO) on the quality characteristics and storage stability of sucuk (Turkish dry-fermented sausage). The partial (25, 50, 75%) and complete (100%) replacement of added beef fat with IPKO were carried out during sucuk processing. According to the study results, replacement of beef fat with IPKO resulted in significant increase in the concentrations of caprylic, capric, lauric and mryistic acid and decrease in the concentrations of stearic, oleic and linoleic acid in sucuk (P<0...
April 21, 2017: Meat Science
https://www.readbyqxmd.com/read/28452961/relationship-of-the-reported-intakes-of-fat-and-fatty-acids-to-body-weight-in-us-adults
#20
Susan K Raatz, Zach Conrad, LuAnn K Johnson, Matthew J Picklo, Lisa Jahns
Dietary fat composition may modulate energy expenditure and body weight. Little is known about the relationship between fatty acid intake and body weight at a population level. The purposes of this study were to compare intakes of energy, macronutrients, and individual fatty acids across BMI categories (1) for the US adult population and, (2) by sociodemographic groups. Reported dietary intake data from the National Health and Nutrition Examination Survey (NHANES) and What We Eat in America (WWEIA) surveys in the years 2005-2012 were analyzed...
April 28, 2017: Nutrients
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