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https://www.readbyqxmd.com/read/29127809/optimisation-of-the-antifungal-potency-of-the-amidated-peptide-h-orn-orn-trp-trp-nh2-against-food-contaminants
#1
Thibaut Thery, Yvonne O'Callaghan, Nora O'Brien, Elke K Arendt
The design of novel efficient antimicrobial peptides (AMPs) faces several issues, such as cost of synthesis, proteolytic stability or cytotoxicity. The identification of key determinants involved in the activity of AMPs, such as cationicity and amphipathicity, allowed the synthesis of short peptides with optimized properties. An ultrashort peptide made of the sequence H-Orn-Orn-Trp-Trp-NH2 (O3TR) showed antifungal activity against several contaminants from food products. This peptide inhibited the growth of the filamentous fungi Fusarium culmorum, Penicillium expansum and Aspergillus niger within a range of concentration of 12...
November 8, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29079969/coconut-products-improve-signs-of-diet-induced-metabolic-syndrome-in-rats
#2
Sunil K Panchal, Sharyn Carnahan, Lindsay Brown
Increasing prevalence of obesity and metabolic syndrome warrants identification of potential therapeutic options for intervention. This study tested commercially available Virgin Coconut Oil and Coconut Nourish, as coconuts are rich sources of lauric and myristic acids. Male Wistar rats were fed either corn starch diet (C); high-carbohydrate, high-fat diet (H); high-carbohydrate, high-virgin coconut oil diet (HV); or high-carbohydrate, high-coconut Nourish diet (HN) for 16 weeks. Metabolic, liver, and cardiovascular health parameters were measured during and at the end of the study...
October 27, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/29043450/immobilization-of-lipase-on-carboxylic-acid-modified-silica-nanoparticles-for-olive-oil-glycerolysis
#3
Abhishek Kumar Singh, Mausumi Mukhopadhyay
In this study, the silica nanoparticles surface was modified by carboxylic acid with different number of alkyl chain and two different lipases were immobilized on it to increase the glycerolysis activity of the immobilized lipases in organic solvent system. Silica nanoparticles of about 15 nm diameter were grafted with various carboxylic acid modifiers from valeric, caprylic, capric, lauric, stearic and oleic acids. Lipases from Candida antarctica and Candida rugosa were immobilized onto the carboxylic acid, modified silica nanoparticles and used in the mono and diglycerides production through glycerolysis with or without organic solvents...
October 17, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/29037667/hexafluoroisopropanol-induced-salt-free-catanionic-surfactant-coacervate-extraction-method-for-determination-of-fluoroquinolones-in-milk-samples
#4
Jia Xu, Xiao Li, Cao Li, Jia Chen, Yuxiu Xiao
Coacervation and phase separation were first reported in salt-free catanionic surfactant aqueous systems based on lauric acid (LA) and dodecyltrimethylammonium hydroxide (DTAOH), using hexafluoroisopropanol (HFIP) as a coacervate-inducing agent. The liquid-liquid two-phase separation occurs over a wide of LA/DTAOH molar ratios (78:22-0:100mol/mol) and total surfactant concentrations (5-200mmolL(-1)) upon adding a small amount of HFIP (<10%, v/v). HFIP-induced salt-free LA/DTAOH catanionic surfactant system has much wider two-phase region than HFIP-induced salt-containing sodium laurate/dodecyltrimethylammonium bromide system...
March 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29035747/studies-on-the-adsorption-and-desorption-of-mitoxantrone-to-lauric-acid-albumin-coated-iron-oxide-nanoparticles
#5
Jan Zaloga, Artem Feoktystov, Vasil M Garamus, Weronika Karawacka, Alexander Ioffe, Thomas Brückel, Rainer Tietze, Christoph Alexiou, Stefan Lyer
A rational use of superparamagnetic iron oxide nanoparticles (SPIONs) in drug delivery, diagnostics, and other biomedical applications requires deep understanding of the molecular drug adsorption/desorption mechanisms for proper design of new pharmaceutical formulations. The adsorption and desorption of the cytostatic Mitoxantrone (MTO) to lauric acid-albumin hybrid coated particles SPIONs (SEON(LA-HSA)) was studied by Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), surface titration, release experiments and small-angle neutron and X-ray scattering...
September 28, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29031401/screening-of-some-lesser-known-tree-borne-oilseed-plants-from-north-east-india-for-their-oil-content-and-major-fatty-acid-components
#6
Bithika Chaliha, Lipika Lahkar, Anjali Doley, Rumi Kotoky, Siddhartha P Saikia, Subhan C Nath
Forest of North-East India is rich in a variety of tree borne oilseeds and there were no serious efforts to exploit the less known oilseeds of the forest origin. Considering the vast plant wealth and with an objective to explore these untapped potentialities of oilseed resources of NE India, a research program was undertaken. The present communication is based on the investigation of seeds of 14 lesser known plant species for fats and oils. The screened plant species exhibited oil yield ranging from 4.71% to 48...
November 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29018344/xanthates-as-useful-probes-for-testing-the-active-sites-of-cytochromes-p450-4a11-and-2e1
#7
Tsveta Stoyanova, Iglika Lessigiarska, Momir Mikov, Ilza Pajeva, Stanislav Yanev
Xanthates (alkyl or aryl derivatives of dithiocarbonic acid) have been shown to be selective mechanism-based inactivators of cytochromes P450 2B1/2B6 and 2E1 due to covalent binding of a reactive intermediate to apoprotein after double hydrogen abstraction at α-carbon atom, suggesting interaction of the xanthate dithiocarbonic head with the enzyme heme. The structures of xanthates with a long alkyl chain are similar to the fatty acids. Saturated fatty acids (FA) such as lauric acid (LA), are metabolized by different cytochrome P450 isoforms to ω- and (ω-1)-hydroxy products, in humans done by CYP4A11 and CYP2E1, respectively...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29018033/expression-and-functional-characterization-of-breast-cancer-associated-cytochrome-p450-4z1-in-saccharomyces-cerevisiae
#8
Matthew G McDonald, Sutapa Ray, Clara J Amorosi, Katherine A Sitko, John P Kowalski, Lorela Paco, Abhinav Nath, Byron M Gallis, Rheem A Totah, Maitreya J Dunham, Douglas M Fowler, Allan E Rettie
CYP4Z1 is an 'orphan' P450 enzyme that has provoked interest because of its hypothesized role in breast cancer through formation of the signaling molecule 20-HETE. We expressed human CYP4Z1 in Saccharomyces cerevisiae and evaluated its catalytic capabilities towards arachidonic and lauric acids (AA and LA). Specific and sensitive mass spectrometry assays enabled discrimination of the regioselectivity of hydroxylation of these two fatty acids. CYP4Z1 generated 7-, 8-, 9-, 10- and 11-hydroxy LA, while the 12-hydroxy metabolite was not detected...
October 10, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28977478/hollow-fiber-supported-ionic-liquids-liquid-phase-micro-extraction-followed-by-high-performance-liquid-chromatography-for-the-determination-of-polycyclic-aromatic-hydrocarbons-in-milk-samples
#9
Meng Wang, Chunsheng Cheng, Chunbo Liu, Yaling Yang
A rapid, simple, reliable and efficient hollow fiber supported ionic liquids liquid-phase micro-extraction method (IL-HF-LPME) followed by high-performance liquid chromatography was successfully applied to the determination of four kinds of polycyclic aromatic hydrocarbons (PAHs) in milk samples. In the IL-HF-LPME method, a mixture of [OMIM]PF6 and lauric acid, in a ratio of 3:1, was immobilized in the pores of a polypropylene hollow fiber used as extraction solvent. A series of essential parameters influencing the extraction efficiency were investigated and optimized...
August 22, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28972495/characterization-of-sulphide-silt-pe-loids-in-some-lakes-within-adjara-region-and-determination-of-the-biologically-active-compounds-content
#10
T Masiukovichi, M Jokhadze, T Murtazashvili, A Bakuridze
Medicinal muds, so called Peloids in the last decade attract attention in many countries as effective means for the treatment- preventive, and perfumery-cosmetic purposes. It has been established that the possibilities of this formation of nature are not limited to the many-year experience of the mankind. In terms of further improvement of the human social sphere, nowadays peloids are referred to as XXI century material. The aim of the research was to study the physical-chemical characteristics, such as: humidity, pH, ash content, bulk (volumetric) density and organoleptic properties of sulphide silt peloids of some Adjara region lakes, as well as to determine the content of mineral and organic compounds (humic and organic acids)...
September 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28955755/cell-free-production-and-characterisation-of-human-uncoupling-protein-1-3
#11
Etienne Rebuffet, Anna Frick, Michael Järvå, Susanna Törnroth-Horsefield
The uncoupling proteins (UCPs) leak protons across the inner mitochondrial membrane, thus uncoupling the proton gradient from ATP synthesis. The main known physiological role for this is heat generation by UCP1 in brown adipose tissue. However, UCPs are also believed to be important for protection against reactive oxygen species, fine-tuning of metabolism and have been suggested to be involved in disease states such as obesity, diabetes and cancer. Structural studies of UCPs have long been hampered by difficulties in sample preparation with neither expression in yeast nor refolding from inclusion bodies in E...
July 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28946644/glycyrrhetinic-acid-liposomes-containing-mannose-diester-lauric-diacid-cholesterol-conjugate-synthesized-by-lipase-catalytic-acylation-for-liver-specific-delivery
#12
Jing Chen, Yuchao Chen, Yi Cheng, Youheng Gao
Mannose-diester lauric diacid-cholesterol (Man-DLD-Chol), as a liposomal target ligand, was synthesized by lipase catalyzed in a non-aqueous medium. Its chemical structure was confirmed by mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy. Glycyrrhetinic acid (GA) liposomes containing Man-DLD-Chol (Man-DLD-Chol-GA-Lp) were prepared by the film-dispersion method. We evaluated the characterizations of liposomes, drug-release in vitro, the hemolytic test, cellular uptake, pharmacokinetics, and the tissue distributions...
September 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28936872/characterization-of-lipophilized-monomeric-and-oligomeric-grape-seed-flavan-3-ol-derivatives
#13
Mingshun Chen, Shujuan Yu
Grape seed proanthocyanidins, composed of flavan-3-ols of different degrees of polymerization, are natural food antioxidants. Flavan-3-ols in grape seed are usually polyhydroxy derivatives which exhibit hydrophilic character. Monomeric and oligomeric flavan-3-ols were modified structurally to improve their lipophilicity, expand their application in lipophilic media, and enhance their cellular absorption in the body. The esterification of the water-soluble flavan-3-ols was prepared by Lipozyme TL IM with lauric acid, and their enhanced lipophilicity was confirmed by a 1-octanol/water partition coefficient...
October 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28925980/changes-in-fatty-acid-composition-of-human-milk-in-response-to-cold-like-symptoms-in-the-lactating-mother-and-infant
#14
Andrew S Gardner, Ibrahim A Rahman, Ching T Lai, Anna Hepworth, Naomi Trengove, Peter E Hartmann, Donna T Geddes
Infants rely on their innate immune systems to protect them from infection. Human milk (HM) contains fatty acids (FAs) and monoacylglycerols that are known to exhibit antiviral and antibacterial properties in vitro. The specific fat content of HM may potentially affect the efficacy of this antimicrobial activity. This preliminary study investigates whether the proportions of FA in HM change in response to infections, leading to cold-like symptoms in the mother or infant. Milk samples were obtained from mothers (n = 26) when they and their infants were healthy, and when mother, infant, or both suffered cold-like symptoms...
September 19, 2017: Nutrients
https://www.readbyqxmd.com/read/28924490/the-lauric-acid-activated-signaling-prompts-apoptosis-in-cancer-cells
#15
Rosamaria Lappano, Anna Sebastiani, Francesca Cirillo, Damiano Cosimo Rigiracciolo, Giulia Raffaella Galli, Rosita Curcio, Roberta Malaguarnera, Antonino Belfiore, Anna Rita Cappello, Marcello Maggiolini
The saturated medium-chain fatty-acid lauric acid (LA) has been associated to certain health-promoting benefits of coconut oil intake, including the improvement of the quality of life in breast cancer patients during chemotherapy. As it concerns the potential to hamper tumor growth, LA was shown to elicit inhibitory effects only in colon cancer cells. Here, we provide novel insights regarding the molecular mechanisms through which LA triggers antiproliferative and pro-apoptotic effects in both breast and endometrial cancer cells...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28915943/derivatization-enhanced-separation-and-sensitivity-of-long-chain-free-fatty-acids-application-to-asthma-using-targeted-and-non-targeted-liquid-chromatography-mass-spectrometry-approach
#16
Xiqing Bian, Baoqing Sun, Peiyan Zheng, Na Li, Jian-Lin Wu
Long chain-free fatty acids (LCFFAs) play pivotal roles in various physiological functions, like inflammation, insulin resistance, hypertension, immune cell behavior and other biological activities. However, the detection is obstructed by the low contents, structural diversity, high structural similarity, and matrix interference. Herein, a fast cholamine-derivatization, within 1 min at room temperature, coupled with liquid chromatography-mass spectrometry (LC-MS) approach was developed to determine LCFFAs in complex samples...
October 9, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28912830/in-vitro-oxidative-decarboxylation-of-free-fatty-acids-to-terminal-alkenes-by-two-new-p450-peroxygenases
#17
Huifang Xu, Linlin Ning, Wenxia Yang, Bo Fang, Cong Wang, Yun Wang, Jian Xu, Severine Collin, Frederic Laeuffer, Laurent Fourage, Shengying Li
BACKGROUND: P450 fatty acid decarboxylases represented by the unusual CYP152 peroxygenase family member OleTJE have been receiving great attention recently since these P450 enzymes are able to catalyze the simple and direct production of 1-alkenes for potential applications in biofuels and biomaterials. To gain more mechanistic insights, broader substrate spectra, and improved decarboxylative activities, it is demanded to discover and investigate more P450 fatty acid decarboxylases. RESULTS: Here, we describe for the first time the expression, purification, and in vitro biochemical characterization of two new CYP152 peroxygenases, CYP-Aa162 and CYP-Sm46Δ29, that are capable of decarboxylating straight-chain saturated fatty acids...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28899400/impact-of-combined-sodium-chloride-and-saturated-long-chain-fatty-acid-challenge-on-the-differentiation-of-t-helper-cells-in-neuroinflammation
#18
Anna Hammer, Anne Schliep, Stefanie Jörg, Aiden Haghikia, Ralf Gold, Markus Kleinewietfeld, Dominik N Müller, Ralf A Linker
BACKGROUND: There has been a marked increase in the incidence of autoimmune diseases like multiple sclerosis (MS) in the last decades which is most likely driven by a change in environmental factors. Here, growing evidence suggests that ingredients of a Western diet like high intake of sodium chloride (NaCl) or saturated fatty acids may impact systemic immune responses, thus increasing disease susceptibility. Recently, we have shown that high dietary salt or long-chain fatty acid (LCFA) intake indeed aggravates T helper (Th) cell responses and neuroinflammation...
September 12, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28895716/synthesis-free-phase-selective-gelator-for-oil-spill-remediation
#19
Yaowen Cui, Mei-Chun Li, Qinglin Wu, John A Pojman, Daniel G Kuroda
A new deep eutectic solvent (DES) was developed as a phase-selective gelator for oil-spill remediation. The newly designed nonionic DES is based on a combination of an amide (N-methylacetamide) and a long chain carboxylic acid (lauric acid) and does not require any synthetic procedure besides mixing. Our studies show that the DES works as gelator by forming a gel between lauric acid and the hydrocarbon, whereas the amide serves to form the DES and dissolves in water during the gelation process. In addition, the DES material has gelation properties comparable to those considered as state-of-the-art...
October 4, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28886572/myristic-acid-in-amniotic-fluid-produces-appetitive-responses-in-human-newborns
#20
Ana G Gutiérrez-García, Carlos M Contreras, Cynthia Díaz-Marte
BACKGROUND: A mixture of eight fatty acids (lauric acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, elaidic acid, and linoleic acid) that are contained in human amniotic fluid, colostrum, and milk produces appetitive responses in newborns, suggesting the existence of a transition of sensorial cues that guide newborns to the maternal breast. OBJECTIVE: To explore the ability of each of these eight fatty acids individually to produce appetitive responses in newborns...
September 5, 2017: Early Human Development
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