keyword
https://read.qxmd.com/read/38543828/acalculous-cholecystitis-as-a-complication-of-primary-epstein-barr-virus-infection-a-case-based-scoping-review-of-the-literature
#1
REVIEW
Aristotelis Tsiakalos, Georgios Schinas, Aggelos Karatzaferis, Emmanouil Angelos Rigopoulos, Christos Pappas, Eleni Polyzou, Effrosyni Dimopoulou, George Dimopoulos, Karolina Akinosoglou
Primary Epstein-Barr virus (EBV) infection manifests with diverse clinical symptoms, occasionally resulting in severe complications. This scoping review investigates the rare occurrence of acute acalculous cholecystitis (AAC) in the context of primary EBV infection, with a focus on understanding its prevalence, clinical features, and underlying mechanisms. The study also explores EBV infection association with Gilbert syndrome, a condition that potentially exacerbates the clinical picture. Additionally, a case report of an 18-year-old female presenting with AAC and ascites secondary to EBV infection enhances the review...
March 18, 2024: Viruses
https://read.qxmd.com/read/38514990/unconjugated-hyperbilirubinemia-in-acetaminophen-related-acute-liver-failure
#2
JOURNAL ARTICLE
Marie Philippart, Jean-Baptiste Mesland, Vincent Haufroid, Christine Collienne, Philippe Hantson
BACKGROUND In the absence of liver transplantation, the natural history of acetaminophen-induced liver failure is characterized by a progressive increase of liver function tests, including bilirubin mainly as its conjugated form. The presence of high levels of unconjugated bilirubin is more unusual; its etiology is unclear and its prognostic factor has been poorly investigated. CASE REPORT A 52-year-old man with a history of chronic analgesics, alcohol, and illicit drug abuse developed acute liver failure in relationship with the ingestion of largely supra-therapeutic doses of acetaminophen over the days preceding admission...
March 22, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38514260/-ugt1a1-gene-mutation-spectrum-with-indirect-hyperbilirubinemia-in-children
#3
JOURNAL ARTICLE
Y Shen, H M Guo, Y C Zheng, B X Zheng, K L Yan, G P Kong, Q Lin, Y Jin, Z F Liu, M Li
Objective: To explore the relevancy between the uridine diphosphate-glucuronylgly-cosyltransferase 1A1 (UGT1A1) gene mutation and the phenotype of indirect hyperbilirubinemia in children. Methods: Sixteen cases with indirect hyperbilirubinemia who visited the Department of Gastroenterology, Children's Hospital of Nanjing Medical University from July 2013 to November 2019 were retrospectively analyzed and were divided into Gilbert syndrome (GS), Crigler-Najjar syndrome type II (CNS-II), and indirect hyperbilirubinemia groups unexplained by UGT1A1 gene mutations...
February 20, 2024: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://read.qxmd.com/read/38494319/an-abc-approach-to-cardiothoracic-complications-and-sequelae-of-covid-19-a-tertiary-centre-experience
#4
REVIEW
Saad Qutab, Sunshine Alonzo, A Agatha Crerar-Gilbert, Brendan Madden
The Coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused unprecedented challenges to healthcare professionals (HCPs) worldwide. HCPs faced an unknown disease causing many complications, including now well-established acute respiratory distress syndrome (ARDS) and pulmonary artery thromboembolic disease, and some not so well known, for instance, tracheobronchomalacia, tracheal tear or dehiscence, granulation tissue formation and pulmonary hypertension...
November 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
https://read.qxmd.com/read/38408932/comprehensive-knowledge-about-hiv-aids-and-associated-factors-among-reproductive-age-women-in-liberia
#5
JOURNAL ARTICLE
Beminate Lemma Seifu, Gilbert Eshun, Getayeneh Antehunegn Tesema, Frank Kyei-Arthur
INTRODUCTION: Acquired Immune Deficiency Syndrome (AIDS) continues to be a deadly pandemic and a serious threat to public health. Globally, reproductive age women are more likely to be infected with Human Immunodeficiency Virus (HIV). Comprehensive knowledge about HIV/AIDS is pivotal in the fight against AIDS. However, comprehensive HIV/AIDS knowledge is low in Sub-Saharan African (SSA) nations including Liberia, which contributes to the high incidence of HIV in these nations. This study assessed the level of comprehensive knowledge about HIV/AIDS and its associated factors among reproductive age women in Liberia...
February 26, 2024: BMC Public Health
https://read.qxmd.com/read/38392908/neurodevelopmental-outcomes-of-normocephalic-colombian-children-with-antenatal-zika-virus-exposure-at-school-entry
#6
JOURNAL ARTICLE
Sarah B Mulkey, Elizabeth Corn, Meagan E Williams, Colleen Peyton, Regan Andringa-Seed, Margarita Arroyave-Wessel, Gilbert Vezina, Dorothy I Bulas, Robert H Podolsky, Michael E Msall, Carlos Cure
The long-term neurodevelopmental effects of antenatal Zika virus (ZIKV) exposure in children without congenital Zika syndrome (CZS) remain unclear, as few children have been examined to the age of school entry level. A total of 51 Colombian children with antenatal ZIKV exposure without CZS and 70 unexposed controls were evaluated at 4-5 years of age using the Behavior Rating Inventory of Executive Function (BRIEF), the Pediatric Evaluation of Disability Inventory (PEDI-CAT), the Bracken School Readiness Assessment (BSRA), and the Movement Assessment Battery for Children (MABC)...
February 13, 2024: Pathogens
https://read.qxmd.com/read/38341029/intrinsic-risk-factors-for-alpha-gal-syndrome-in-a-case-control-study-2019-2020
#7
JOURNAL ARTICLE
Marissa L Taylor, Gilbert J Kersh, Johanna S Salzer, Emma S Jones, Alison M Binder, Paige A Armstrong, Shailesh K Choudhary, Grace K Commins, Claire L Amelio, Brad J Biggerstaff, Charles B Beard, Lyle R Petersen, Scott P Commins
BACKGROUND: Alpha-gal syndrome (AGS) is an allergy to galactose-α-1,3-galactose (alpha-gal), a carbohydrate found in most mammals. Evidence indicates that AGS develops following a tick bite, and in the United States, AGS is most associated with bites from Amblyomma americanum (lone star tick); however, not all persons bitten by ticks develop clinical AGS. OBJECTIVE: This study investigated intrinsic risk factors associated with the development of AGS. METHODS: We performed a case-control study among adults presenting for diagnosis or management of AGS at an allergy clinic in North Carolina during 2019-2020 and compared them to controls enrolled from two nearby internal medicine clinics...
February 8, 2024: Annals of Allergy, Asthma & Immunology
https://read.qxmd.com/read/38334089/prolonged-jaundice-in-a-premature-breastfed-infant-with-gilbert-s-syndrome
#8
JOURNAL ARTICLE
Frances Strobl, Melissa Ann Theurich
INTRODUCTION: Neonatal jaundice and prematurity pose significant barriers to breastfeeding in the first days of life. There is limited literature exploring the relationship between prolonged jaundice in breastfed infants and Gilbert's (Meulengraght) syndrome. This case study describes the diagnostic and therapeutic challenges associated with Gilbert's syndrome in a late preterm breastfed infant born in Germany. MAIN ISSUE: In this case report, an infant born to a primipara woman presented at 3 weeks postpartum to an International Board Certified Lactation Consultant...
February 9, 2024: Journal of Human Lactation
https://read.qxmd.com/read/38327389/cold-agglutinin-disease-and-covid-19-a-scoping-review-of-treatments-and-outcomes
#9
JOURNAL ARTICLE
Jackson S Musuuza, Silpa Kumar, Dheeraj Kumar Posa, Aakash Hans, Sankett Nayyar, Leslie Christensen, Gilbert-Roy Kamoga
BACKGROUND: Reports suggest that patients with both acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and cold agglutinin disease (CAD) may experience poorer survival when treated with rituximab. We conducted a scoping review to evaluate severe outcomes, including intensive care unit (ICU) admission and mortality, in coronavirus disease 2019 (COVID-19) patients with CAD on various treatments, including rituximab. METHODS: This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR)...
January 2024: Journal of Clinical Medicine Research
https://read.qxmd.com/read/38266109/sars-cov-2-viral-clearance-and-evolution-varies-by-type-and-severity-of-immunodeficiency
#10
JOURNAL ARTICLE
Yijia Li, Manish C Choudhary, James Regan, Julie Boucau, Anusha Nathan, Tessa Speidel, May Yee Liew, Gregory E Edelstein, Yumeko Kawano, Rockib Uddin, Rinki Deo, Caitlin Marino, Matthew A Getz, Zahra Reynolds, Mamadou Barry, Rebecca F Gilbert, Dessie Tien, Shruti Sagar, Tammy D Vyas, James P Flynn, Sarah P Hammond, Lewis A Novack, Bina Choi, Manuela Cernadas, Zachary S Wallace, Jeffrey A Sparks, Jatin M Vyas, Michael S Seaman, Gaurav D Gaiha, Mark J Siedner, Amy K Barczak, Jacob E Lemieux, Jonathan Z Li
Despite vaccination and antiviral therapies, immunocompromised individuals are at risk for prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but the immune defects that predispose an individual to persistent coronavirus disease 2019 (COVID-19) remain incompletely understood. In this study, we performed detailed viro-immunologic analyses of a prospective cohort of participants with COVID-19. The median times to nasal viral RNA and culture clearance in individuals with severe immunosuppression due to hematologic malignancy or transplant (S-HT) were 72 and 40 days, respectively, both of which were significantly longer than clearance rates in individuals with severe immunosuppression due to autoimmunity or B cell deficiency (S-A), individuals with nonsevere immunodeficiency, and nonimmunocompromised groups ( P < 0...
January 24, 2024: Science Translational Medicine
https://read.qxmd.com/read/38236708/pre-hospital-rule-out-of-non-st-segment-elevation-acute-coronary-syndrome-by-a-single-troponin-final-one-year-outcomes-of-the-artica-randomised-trial
#11
JOURNAL ARTICLE
Goaris W A Aarts, Cyril Camaro, Eddy M M Adang, Laura Rodwell, Roger van Hout, Gijs Brok, Anouk Hoare, Frank de Pooter, Walter de Wit, Gilbert E Cramer, Roland R J van Kimmenade, Eva Ouwendijk, Martijn H Rutten, Erwin Zegers, Robert-Jan M van Geuns, Marc E R Gomes, Peter Damman, Niels van Royen
BACKGROUND AND AIMS: The healthcare burden of acute chest pain is enormous. In the randomised ARTICA trial we showed that pre-hospital identification of low-risk patients and rule-out of non-ST-segment elevation acute coronary syndrome (NSTE-ACS) with point-of-care (POC) troponin measurement reduces 30-day healthcare costs with low major adverse cardiac events (MACE) incidence. Here we present the final one-year results of the ARTICA trial. METHODS: Low-risk patients with suspected NSTE-ACS were randomised to pre-hospital rule-out with POC troponin measurement or emergency department (ED) transfer...
January 17, 2024: European Heart Journal. Quality of Care & Clinical Outcomes
https://read.qxmd.com/read/38196626/leveraging-informative-missing-data-to-learn-about-acute-respiratory-distress-syndrome-and-mortality-in-long-term-hospitalized-covid-19-patients-throughout-the-years-of-the-pandemic
#12
Emily Getzen, Amelia Lm Tan, Gabriel Brat, Gilbert S Omenn, Zachary Strasser, Qi Long, John H Holmes, Danielle Mowery
Electronic health records (EHRs) contain a wealth of information that can be used to further precision health. One particular data element in EHRs that is not only under-utilized but oftentimes unaccounted for is missing data. However, missingness can provide valuable information about comorbidities and best practices for monitoring patients, which could save lives and reduce burden on the healthcare system. We characterize patterns of missing data in laboratory measurements collected at the University of Pennsylvania Hospital System from long-term COVID-19 patients and focus on the changes in these patterns between 2020 and 2021...
December 19, 2023: medRxiv
https://read.qxmd.com/read/38183238/propofol-infusion-syndrome-following-endoscopic-tracheoplasty-and-jet-ventilation-case-report
#13
JOURNAL ARTICLE
Bonnie Chen, Andrew Tran, Mohammed Alnijoumi, Mark R Gilbert
OBJECTIVE: We present a case of propofol infusion syndrome (PRIS) following jet ventilation. METHOD: Case report and review of literature. RESULTS: A 70-year-old man required CO2 laser endoscopic tracheoplasty for tracheal and subglottic stenosis due to A-frame deformity. Postoperatively, the patient was reintubated for respiratory distress and propofol was resumed. Over the next two days the patient developed acute kidney injury, leukocytosis, acute primary respiratory acidosis with high anion gap metabolic acidosis, multiple end organ damage, elevated cardiac markers, and worsening lactic acidosis...
April 2024: Annals of Otology, Rhinology, and Laryngology
https://read.qxmd.com/read/38179880/gilbert-s-syndrome-leads-to-elevated-bilirubin-after-initiation-of-elexacaftor-tezacaftor-ivacaftor-in-people-with-cystic-fibrosis
#14
JOURNAL ARTICLE
Nidhi Patel, Maria Ansar, Anh Pham, Kelly Thomsen, Cameron J McKinzie, Deepika Polineni, Charles R Esther, Rebekah F Brown
Nine people with cystic fibrosis (pwCF) were found to have isolated elevations in serum total bilirubin after starting elexacaftor/tezacaftor/ivacaftor (ETI) that were associated with Gilbert's Syndrome. In longitudinal examination, total bilirubin levels increased substantially after initiation of ETI without elevations in liver transaminases in those with this syndrome. Because elevated bilirubin levels in Gilbert's Syndrome are benign, ETI was able to be continued in these individuals. Genetic testing for this relatively common syndrome should be strongly considered for pwCF experiencing isolated hyperbilirubinemia after starting ETI, since appropriate diagnosis may help pwCF avoid unnecessary interruption in this therapy with significant health benefits in CF...
January 5, 2024: Pediatric Pulmonology
https://read.qxmd.com/read/38143515/development-of-a-pharmacokinetic-model-that-accounts-for-the-plasma-concentrations-of-conjugated-and-unconjugated-bilirubin-observed-in-a-variety-of-disease-states
#15
JOURNAL ARTICLE
David G Levitt, Michael D Levitt
INTRODUCTION: For a large variety of liver pathologies, the plasma unconjugated (UB) and conjugated (CB) bilirubin concentrations appear to be coupled. For example, in alcoholic cirrhosis, UB and CB are roughly the same over a large range of total bilirubin, requiring an initial massive increase (about 40-fold) in plasma CB to reach the level of UB and then similar increases in UB and CB as the disease progresses. This coupling has been either unrecognized or ignored and this paper is the first attempt to try to explain it quantitatively in terms of known hepatic cell metabolic and membrane transport properties...
2023: Clinical and Experimental Gastroenterology
https://read.qxmd.com/read/38117865/autoimmune-retinopathy-in-a-patient-with-stiff-person-syndrome-a-case-report
#16
JOURNAL ARTICLE
Ronak M Shah, Maya H Maloney, Aubrey L Gilbert, Amar P Patel, Robin A Vora
PURPOSE: To describe a patient who developed retinal degeneration associated with autoimmune retinopathy (AIR) and who was also found to have anti-glutamic acid decarboxylase (GAD65) autoantibodies and the diagnosis of stiff-person syndrome (SPS). METHODS: Ophthalmologic workup consisted of clinical examination, multi-modality retinal imaging, and electrophysiologic testing. Further neurologic assessment including relevant serum and cerebrospinal fluid studies was also conducted...
December 19, 2023: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38110026/association-of-plasma-creatinine-phosphokinase-elevation-and-a-history-of-idiopathic-cardiomyopathy-in-recipients-of-heart-transplant
#17
JOURNAL ARTICLE
Pierre Ambrosi, Alberto Riberi, Shahram Attarian, Karine Nguyen, Régis Guieu, Gilbert Habib
Plasma creatinine phosphokinase (CPK) elevation is frequent after heart transplantation. In the present study, we tested the hypothesis that this CPK elevation is related to idiopathic cardiomyopathy as primary cardiac disease. We included 203 patients who survived >1 year after heart transplantation. Plasma CPK was measured every 4 months during a 15.1 ± 7.7-year follow-up. In univariate analysis, CPK elevation was significantly associated with age at transplantation, length of follow-up, treatment with everolimus, and idiopathic cardiomyopathy as primary cardiac disease...
December 16, 2023: American Journal of Cardiology
https://read.qxmd.com/read/38090676/delayed-presentation-of-popliteal-artery-injury-after-salter-harris-iii-proximal-tibia-fracture
#18
Alexandra H Seidenstein, Timothy W Torrez, Jacob A Garcia, Shadi K Awad, Henry Debell, Shawn R Gilbert, Kevin A Williams
INTRODUCTION: Proximal tibia physeal fractures in children are not very common but can be dangerous because they can harm popliteal fossa structures, especially the popliteal artery. Popliteal artery injuries (PAI) are most commonly the result of trauma to the lower extremity, including blunt force, hyperextension injuries, complex fractures, and knee dislocations that can compromise popliteal neurovascular structures. Case Presentation. A 14-year-old boy presents to the emergency department after being transferred from an outside hospital 24 hours after a left lower extremity hyperextension injury...
2023: Case Reports in Orthopedics
https://read.qxmd.com/read/38065603/an-abc-approach-to-cardiothoracic-complications-and-sequelae-of-covid-19-a-tertiary-centre-experience
#19
REVIEW
Saad Qutab, Sunshine Alonzo, A Agatha Crerar-Gilbert, Brendan Madden
The Coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused unprecedented challenges to healthcare professionals (HCPs) worldwide. HCPs faced an unknown disease causing many complications, including now well-established acute respiratory distress syndrome (ARDS) and pulmonary artery thromboembolic disease, and some not so well known, for instance, tracheobronchomalacia, tracheal tear or dehiscence, granulation tissue formation and pulmonary hypertension...
November 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
https://read.qxmd.com/read/38051574/assessment-of-a-digital-symptom-checker-tool-s-accuracy-in-suggesting-reproductive-health-conditions-clinical-vignettes-study
#20
JOURNAL ARTICLE
Kimberly Peven, Aidan P Wickham, Octavia Wilks, Yusuf C Kaplan, Andrei Marhol, Saddif Ahmed, Ryan Bamford, Adam C Cunningham, Carley Prentice, András Meczner, Matthew Fenech, Stephen Gilbert, Anna Klepchukova, Sonia Ponzo, Liudmila Zhaunova
BACKGROUND: Reproductive health conditions such as endometriosis, uterine fibroids, and polycystic ovary syndrome (PCOS) affect a large proportion of women and people who menstruate worldwide. Prevalence estimates for these conditions range from 5% to 40% of women of reproductive age. Long diagnostic delays, up to 12 years, are common and contribute to health complications and increased health care costs. Symptom checker apps provide users with information and tools to better understand their symptoms and thus have the potential to reduce the time to diagnosis for reproductive health conditions...
December 5, 2023: JMIR MHealth and UHealth
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