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https://www.readbyqxmd.com/read/29777516/irisin-levels-increase-after-treatment-in-patients-with-newly-diagnosed-hashimoto-thyroiditis
#1
Z A Uc, S Gorar, S Mizrak, S Gullu
PURPOSE: Irisin is a newly identified myokine secreted by skeletal muscle and has significant effects on body metabolism. Thyroidal functional state has a profound influence on the metabolism of human body. Therefore, the aim of this study was to investigate the possible changes in serum irisin concentrations before and after treatment in hypothyroid subjects. METHODS: The study included 26 patients with overt hypothyroidism due to Hashimoto thyroiditis and 19 healthy subjects...
May 18, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29777277/impact-of-muscle-atrophy-on-bone-metabolism-and-bone-strength-implications-for-muscle-bone-crosstalk-with-aging-and-disuse
#2
REVIEW
T Bettis, B-J Kim, M W Hamrick
Bone fractures in older adults are often preceded by a loss of muscle mass and strength. Likewise, bone loss with prolonged bed rest, spinal cord injury, or with exposure to microgravity is also preceded by a rapid loss of muscle mass. Recent studies using animal models in the setting of hindlimb unloading or botulinum toxin (Botox) injection also reveal that muscle loss can induce bone loss. Moreover, muscle-derived factors such as irisin and leptin can inhibit bone loss with unloading, and knockout of catabolic factors in muscle such as the ubiquitin ligase Murf1 or the myokine myostatin can reduce osteoclastogenesis...
May 18, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29771602/irisin-promotes-proliferation-but-inhibits-differentiation-in-osteoclast-precursor-cells
#3
Yaxian Ma, Xiaoyong Qiao, Rujun Zeng, Ran Cheng, Jun Zhang, Yunyao Luo, Ying Nie, Ying Hu, Zhilan Yang, Jing Zhang, Lin Liu, Wenming Xu, Charles C Xu, Liangzhi Xu
The receptor activator of NF-κB ligand-induced osteoclast differentiation has a critical role in the process of bone metabolism. Overactivation of osteoclastogenesis may result in a series of diseases. Irisin, a novel myokine, which was first reported in 2012, has been proposed to mediate the beneficial metabolic effects of exercise. Studies have demonstrated that irisin targets osteoblasts by promoting osteoblast proliferation and differentiation; however, the underlying mechanism regarding the effect of irisin on osteoclasts remains elusive...
May 17, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29769428/myokine-irisin-induced-protection-against-oxidative-stress-in-vitro-involvement-of-heme-oxygenase-1-and-antioxidazing-enzymes-superoxide-dismutase-2-and-glutathione-peroxidase
#4
A I Mazur-Bialy, K Kozlowska, E Pochec, J Bilski, T Brzozowski
Irisin is a recently discovered myokine reported as protective protein released from exercising skeletal muscles. Although myokines were recently reported to possess the antioxidizing properties, the impact of irisin on the functions of macrophages with respect to its anti-inflammatory potential has not been fully elucidated. Here, we determined the ability of irisin to interact with reactive oxygen species (ROS) in RAW 264.7 murine macrophages. The macrophages were pre-incubated with irisin (0 - 50 nM), some of which had undergone additional co-incubation with bacterial lipopolysaccharide (LPS) (100 ng/ml)...
February 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29745314/obesity-and-its-association-with-irisin-level-among-individuals-with-fndc5-irisin-gene-variants-rs16835198-and-rs726344
#5
Azza Abdu Allah, Eman Abd El Gayed, Sahar Hammoudah, Lama Mohamed El-Attar, Walid Shehab-Eldin
BACKGROUND: Irisin; a novel myokine/adipokine; encoded by FNDC5 gene have been suggested to play an important role in energy metabolism and obesity. However, the genetic variations at this locus and their effects on different metabolic parameters is still poorly understood. AIM: This study aimed to investigate the role of FNDC5/irisin gene polymorphisms (RS16835198 and RS726344) in obese individuals and their genotype phenotype correlation with circulating serum irisin level and other biochemical parameters like glucose, lipid metabolism and liver enzymes...
May 8, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29740336/mediators-and-patterns-of-muscle-loss-in-chronic-systemic-inflammation
#6
REVIEW
Sandra Pérez-Baos, Iván Prieto-Potin, Jorge A Román-Blas, Olga Sánchez-Pernaute, Raquel Largo, Gabriel Herrero-Beaumont
Besides its primary function in locomotion, skeletal muscle (SKM), which represents up to half of human's weight, also plays a fundamental homeostatic role. Through the secretion of soluble peptides, or myokines, SKM interacts with major organs involved in metabolic processes. In turn, metabolic cues from these organs are received by muscle cells, which adapt their response accordingly. This is done through an intricate intracellular signaling network characterized by the cross-talking between anabolic and catabolic pathways...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29735541/multiplex-quantification-identifies-novel-exercise-regulated-myokines-cytokines-in-plasma-and-in-glycolytic-and-oxidative-skeletal-muscle
#7
Hannah Little, Stefanie Y Tan, Francesca Cali, Susana Rodriguez, Xia Lei, Andrew Wolfe, Christopher Hug, G William Wong
Exercise is known to confer major health benefits, but the underlying mechanisms are not well understood. The systemic effects of exercise on multi-organ systems are thought to be partly due to myokines/cytokines secreted by skeletal muscle. The extent to which exercise alters cytokine expression and secretion in different muscle fiber types has not been systematically examined.  Here, we assessed changes in 66 mouse cytokines in serum, and in glycolytic (plantaris) and oxidative (soleus) muscles, in response to sprint, endurance, or chronic wheel running...
May 7, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29731655/immune-regulating-effects-of-exercise-on-cigarette-smoke-induced-inflammation
#8
REVIEW
Ashkan Madani, Katharina Alack, Manuel Jonas Richter, Karsten Krüger
Long-term cigarette smoking (LTCS) represents an important risk factor for cardiac infarction and stroke and the central risk factor for the development of a bronchial carcinoma, smoking-associated interstitial lung fibrosis, and chronic obstructive pulmonary disease. The pathophysiologic development of these diseases is suggested to be promoted by chronic and progressive inflammation. Cigarette smoking induces repetitive inflammatory insults followed by a chronic and progressive activation of the immune system...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29720216/decreased-level-of-irisin-a-skeletal-muscle-cell-derived-myokine-is-associated-with-post-stroke-depression-in-the-ischemic-stroke-population
#9
Wen-Jun Tu, Han-Cheng Qiu, Qiang Liu, Xuemei Li, Ji-Zong Zhao, Xianwei Zeng
BACKGROUND: Depression is a frequent mood disorder in stroke patient. Our aim was to determine irisin levels in serum and investigate their associations with post-stroke depression (PSD) in a 6-month follow-up study in Chinese patients with first-ever acute ischemic stroke (AIS). METHODS: The subjects were first-ever AIS patients who were hospitalized at three stroke centers during the period from January 2015 to December 2016. Neurological and neuropsychological evaluations were conducted at the 6-month follow-up...
May 2, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29700574/serum-brain-derived-neurotrophic-factor-level-and-exercise-tolerance-complement-each-other-in-predicting-the-prognosis-of-patients-with-heart-failure
#10
Atsushi Shibata, Akihisa Hanatani, Yasukatsu Izumi, Ryoko Kitada, Shinichi Iwata, Minoru Yoshiyama
Brain-derived neurotropic factor (BDNF) is a myokine that plays a key role in regulating survival, growth, and maintenance of neurons. We investigated whether the serum BDNF level at discharge could predict the prognosis in patients with heart failure (HF). Furthermore, we aimed to examine the relationship between this myokine and exercise tolerance. We prospectively enrolled 94 patients who were hospitalized for worsening HF and had cardiac rehabilitation. At discharge, the serum BDNF level of all patients was measured using a commercial ELISA kit and they underwent a cardiopulmonary exercise test to measure peak oxygen uptake (peak VO2 )...
April 26, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29663541/eccentric-exercise-increases-circulating-fibroblast-activation-protein-but-not-bioactive-fibroblast-growth-factor-21-in-healthy-humans
#11
Biraj Parmar, Jo E Lewis, Ricardo J Samms, Francis J P Ebling, Christine C Cheng, Andrew C Adams, Joanne Mallinson, Scott Cooper, Tariq Taylor, Reza Ghasemi, Francis B Stephens, Kostas Tsintzas
NEW FINDINGS: What is the central question of this study? The role of FGF21 as an exercise-induced myokine remains controversial. The aim of this study was to determine whether eccentric exercise would augment the release of FGF21 and/or its regulatory enzyme Fibroblast Activation Protein (FAP) from skeletal muscle tissue into the systemic circulation of healthy human volunteers. What is the main finding and its importance? Eccentric exercise does not release total or bioactive FGF21 from human skeletal muscle...
April 16, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29657036/serum-irisin-levels-are-associated-with-adverse-cardiovascular-outcomes-in-patients-with-acute-myocardial-infarction
#12
I-Chang Hsieh, Ming-Yun Ho, Ming-Shien Wen, Chun-Chi Chen, Ming-Jer Hsieh, Chia-Pin Lin, Jih-Kai Yeh, Ming-Lung Tsai, Chia-Hung Yang, Victor Chien-Chia Wu, Kuo-Chun Hung, Chun-Chieh Wang, Chao-Yung Wang
Irisin, a recently identified myokine, regulates mitochondrial function and energy expenditure. The concentration of irisin is significantly altered after ST-elevation myocardial infarction (STEMI). We hypothesized that serum irisin concentration is associated with adverse cardiovascular outcomes after myocardial infarction. Serum irisin concentrations were measured using enzyme-linked immunosorbent assay (ELISA) in 399 patients 28d after the onset of STEMI in a prospective single-center cohort study. We assessed the association between irisin concentrations and adverse cardiovascular events during a 3-year follow-up...
June 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29655944/regular-aerobic-exercise-correlates-with-reduced-anxiety-and-incresed-levels-of-irisin-in-brain-and-white-adipose-tissue
#13
Nazan Uysal, Oguz Yuksel, Servet Kizildag, Zeynep Yuce, Hikmet Gumus, Aslı Karakilic, Guven Guvendi, Basar Koc, Sevim Kandis, Mehmet Ates
We have recently shown that regular voluntary aerobic exercised rats have low levels of anxiety. Irisin is an exercise-induced myokine that is produced by many tissues; and the role it plays in anxiolytic behavior is unknown. In this study we aimed to investigate the correlation between anxiety like behavior and irisin levels following regular voluntary aerobic exercise in male mice. We've have shown that anxiety levels decreased in exercised mice, while irisin levels increased in the brain, brown adipose tissue, white adipose tissue, kidney, and pancreas tissues...
April 12, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29624921/a-genetic-variant-in-il-15r%C3%AE-correlates-with-physical-activity-among-european-american-adults
#14
Michael Bruneau, Sean Walsh, Eric Selinsky, Garrett Ash, Theodore J Angelopoulos, Priscilla Clarkson, Paul Gordon, Niall Moyna, Paul Visich, Robert Zoeller, Paul Thompson, Heather Gordish-Dressman, Eric Hoffman, Joseph Devaney, Linda S Pescatello
BACKGROUND: Interleukin-15 (IL-15) is a myokine associated with muscle strength, possibly by attenuating protein breakdown. A variant in the alpha-receptor (IL-15Rα 1775 A>C, rs2228059) partially modulates the muscle strength and size response to resistance training. We examined if this polymorphism associated with habitual physical activity among European-American adults. METHODS: Men (n = 240, 23.7 ± 0.3 year, body mass index [BMI] 25.3 ± 0.3 kg/m2 ) and women (n = 292, 23...
April 6, 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29608940/an-update-on-the-role-of-irisin-in-the-regulation-of-endocrine-and-metabolic-functions
#15
REVIEW
Mohamed Omer Mahgoub, Crystal D'Souza, Reem S M H Al Darmaki, May M Y H Baniyas, Ernest Adeghate
Irisin is a novel myokine and adipokine that has gained much attention recently due to its mechanisms of action. Irisin is secreted following proteolytic cleavage of its precursor fibronectin type III domain containing 5 (FNDC5). Following its release, irisin exerts its major action by increasing the expression of mitochondrial uncoupling protein 1 (UCP 1), which facilitates the conversion of white adipose tissue (WAT) into beige adipose tissue. Irisin is distributed in various body tissues and several actions have been attributed to its presence in those tissues...
March 30, 2018: Peptides
https://www.readbyqxmd.com/read/29587291/retinoic-acid-increases-fatty-acid-oxidation-and-irisin-expression-in-skeletal-muscle-cells-and-impacts-irisin-in-vivo
#16
Jaume Amengual, Francisco J García-Carrizo, Andrea Arreguín, Hana Mušinović, Nuria Granados, Andreu Palou, M Luisa Bonet, Joan Ribot
BACKGROUND/AIMS: All-trans retinoic acid (ATRA) has protective effects against obesity and metabolic syndrome. We here aimed to gain further insight into the interaction of ATRA with skeletal muscle metabolism and secretory activity as important players in metabolic health. METHODS: Cultured murine C2C12 myocytes were used to study direct effects of ATRA on cellular fatty acid oxidation (FAO) rate (using radioactively-labelled palmitate), glucose uptake (using radioactively-labelled 2-deoxy-D-glucose), triacylglycerol levels (by an enzymatic method), and the expression of genes related to FAO and glucose utilization (by RT-real time PCR)...
March 21, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29582132/association-of-plasma-irisin-with-bone-mineral-density-in-a-large-chinese-population-using-an-extreme-sampling-design
#17
Long-Fei Wu, Dong-Cheng Zhu, Chang-Hua Tang, Bing Ge, Ju Shi, Bing-Hua Wang, Yi-Hua Lu, Pei He, Wen-Yu Wang, Si-Qi Lu, Jiao Zhong, Xu Zhou, Kan Zhu, Wen Ji, Hong-Qin Gao, Hong-Bo Gu, Xing-Bo Mo, Xin Lu, Lei Zhang, Yong-Hong Zhang, Fei-Yan Deng, Shu-Feng Lei
Irisin, a myokine produced by skeletal muscle in response to physical exercise, promotes trans-differentiation of white adipose tissue into brown adipose tissue. Recent evidences suggested that irisin also plays an important role in the control of bone metabolism. This study aimed to ascertain the relationship between plasma irisin and bone mineral density (BMD) in Chinese population by adoption of an extreme sampling method. Based on a large and screened Chinese elderly population (N = 6308), two subgroups with extremely high and low hip BMD were selected for discovery (N = 80, high vs...
March 26, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29574076/detection-and-quantitation-of-irisin-in-human-cerebrospinal-fluid-by-tandem-mass-spectrometry
#18
Qingwei Ruan, Limin Zhang, Jian Ruan, Xixue Zhang, Jie Chen, Cheng Ma, Zhuowei Yu
The myokine irisin can cross the blood brain barrier and act as a neurokine to protect brain function during endurance exercise. However, the mechanism of transport from the blood to cerebrospinal fluid is unknown. Irisin has been detected in rodent and human brain and human cerebrospinal fluid by using commercial antibodies and enzyme linked immunosorbent assay kits. However, as human FNDC5 has an atypical translation start codon, some studies have questioned the specificity of commercial antibodies. Recently, human irisin was identified and quantitated in plasma by using mass spectrometry...
March 21, 2018: Peptides
https://www.readbyqxmd.com/read/29558694/identification-of-ccl5-rantes-as-a-novel-contraction-reducible-myokine-in-mouse-skeletal-muscle
#19
Yuri Ishiuchi, Hitoshi Sato, Narumi Komatsu, Hideo Kawaguchi, Takashi Matsuwaki, Keitaro Yamanouchi, Masugi Nishihara, Taku Nedachi
Skeletal muscle is an endocrine organ that secretes several proteins, which are collectively termed myokines. Although many studies suggest that exercise regulates myokine secretion, the underlying mechanisms remain unclear and all the exercise-dependent myokines have not yet been identified. Therefore, in this study, we attempted to identify novel exercise-dependent myokines by using our recently developed in vitro contractile model. Differentiated C2C12 myotubes were cultured with or without electrical pulse stimulation (EPS) for 24 h to induce cell contraction, and the myokines secreted in conditioned medium were analyzed using a cytokine array...
March 17, 2018: Cytokine
https://www.readbyqxmd.com/read/29558209/electrically-evoked-local-muscle-contractions-cause-an-increase-in-hippocampal-bdnf
#20
Takahiro Maekawa, Riki Ogasawara, Arata Tsutaki, Kihyuk Lee, Satoshi Nakada, Koichi Nakazato, Naokata Ishii
High-intensity exercise has recently been shown to cause an increase in brain-derived neurotropic factor (BDNF) in the hippocampus. Some studies have suggested that myokines secreted from contracting skeletal muscle, such as irisin (one of the truncated form of fibronectin type III domain-containing protein 5 (FNDC5)), play important roles in this process. Thus, we hypothesized that locally evoked muscle contractions may cause an increase of BDNF in the hippocampus through some afferent mechanisms. Under anesthesia, Sprague-Dawley rats were fixed on a custom-made dynamometer and their triceps surae muscles were made to maximally contract via delivery of electric stimulations of the sciatic nerve (100 Hz with 1-ms pulse and 3-s duration)...
March 20, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
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