keyword
MENU ▼
Read by QxMD icon Read
search

myokine

keyword
https://www.readbyqxmd.com/read/27911383/parallel-measurement-of-circadian-clock-gene-expression-and-hormone-secretion-in-human-primary-cell-cultures
#1
Volodymyr Petrenko, Camille Saini, Laurent Perrin, Charna Dibner
Circadian clocks are functional in all light-sensitive organisms, allowing for an adaptation to the external world by anticipating daily environmental changes. Considerable progress in our understanding of the tight connection between the circadian clock and most aspects of physiology has been made in the field over the last decade. However, unraveling the molecular basis that underlies the function of the circadian oscillator in humans stays of highest technical challenge. Here, we provide a detailed description of an experimental approach for long-term (2-5 days) bioluminescence recording and outflow medium collection in cultured human primary cells...
November 11, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27901337/the-effect-of-exercise-induced-weight-loss-on-myokines-and-adipokines-in-overweight-sedentary-females-steps-aerobics-vs-jogging-walking-exercises
#2
Halil Duzova, Esin Gullu, Guner Cicek, Burcu K Koksal, Basak Kayhan, Abdullah Gullu, Ibrahim Sahin
BACKGROUND: The objectives of this study were to verify effects of step-aerobic exercise (SAE) and jogging-walking exercise (JWE) program on myokines and adipokines levels in overweight sedentary females. METHODS: Volunteer subjects (n=25) were assigned to two exercise groups: steps aerobics and jogging-walking. The exercise program given to them was for five days a week and for twelve weeks period. Serum samples were collected from venous blood before and immediately after cardio-respiratory fitness test (CRF) by Bruce protocol and stored at -80 C until they were assayed before 12 weeks exercise program...
November 30, 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27895105/robot-assisted-mechanical-therapy-attenuates-stroke-induced-limb-skeletal-muscle-injury
#3
Chandan K Sen, Savita Khanna, Hallie Harris, Richard Stewart, Maria Balch, Mallory Heigel, Seth Teplitsky, Surya Gnyawali, Cameron Rink
The efficacy and optimization of poststroke physical therapy paradigms is challenged in part by a lack of objective tools available to researchers for systematic preclinical testing. This work represents a maiden effort to develop a robot-assisted mechanical therapy (RAMT) device to objectively address the significance of mechanical physiotherapy on poststroke outcomes. Wistar rats were subjected to right hemisphere middle-cerebral artery occlusion and reperfusion. After 24 h, rats were split into control (RAMT(-)) or RAMT(+) groups (30 min daily RAMT over the stroke-affected gastrocnemius) and were followed up to poststroke d 14...
November 28, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27875543/irisin-ameliorates-hypoxia-reoxygenation-induced-injury-through-modulation-of-histone-deacetylase-4
#4
Yu Tina Zhao, Hao Wang, Shouyan Zhang, Jianfeng Du, Shougang Zhuang, Ting C Zhao
Irisin is a recently identified myokine which brings increases in energy expenditure and contributes to the beneficial effects of exercise through the browning of white adipose tissues. However, its effects in the heart remains unknown. This study sought to determine the effects of irisin on hypoxia/reoxygenation injury and its relationship with HDAC4. Wild type and stable HDAC4-overexpression cells were generated from H9c2 cardiomyoblasts. HDAC4 overexpression cells and wild type H9c2 cells were exposed to 24 hours of hypoxia followed by one hour of reoxygenation in vitro in the presence or absence of irisin (5 ng/ml)...
2016: PloS One
https://www.readbyqxmd.com/read/27834140/hypoxic-exercise-training-promotes-apelin-apj-expression-in-skeletal-muscles-of-high-fat-diet-induced-obese-mice
#5
Weixiu Ji, Lijing Gong, Jianxiong Wang, Hui He, Ying Zhang
Apelin, an endogenous ligand of the G-protein-coupled receptor APJ, is a novel myokine and may play a key role in regulating energy metabolism. The purpose of the present study was to investigate the effects of hypoxic exposure, exercise, and hypoxic exercise training on the expression of apelin and APJ in skeletal muscle of obese mice. 60 two-month old C57BL/6J mice were randomly divided into two groups: 10 in normal diet group (N) and 50 in the high fat diet (HFD) groups. After two months of feeding, the HFD mice whose body weight 20% higher than the average weight of N group were selected as obese mice and were further allocated into four groups: Control (C), Exercise (E), Hypoxia (H), and Exercise plus Hypoxia (E+H), at 8-9 mice/group...
November 11, 2016: Protein and Peptide Letters
https://www.readbyqxmd.com/read/27830278/molecular-communication-from-skeletal-muscle-to-bone-a-review-for-muscle-derived-myokines-regulating-bone-metabolism
#6
REVIEW
Baosheng Guo, Zong-Kang Zhang, Chao Liang, Jie Li, Jin Liu, Aiping Lu, Bao-Ting Zhang, Ge Zhang
Besides the mechanical loading-dependent paradigm, skeletal muscle also serves as an endocrine organ capable of secreting cytokines to modulate bone metabolism. In this review, we focused on reviewing the myokines involved in communication from skeletal muscle to bone, i.e. (1) myostatin and myostatin-binding proteins including follistatin and decorin, (2) interleukins including interleukin-6 (IL-6), interleukin-7 (IL-7) and interleukin-15 (IL-15), (3) insulin-like growth factor 1 (IGF-1) and its binding proteins, (4) other myokines including PGC-1α-irisin system and osteoglycin (OGN)...
November 9, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27828992/relationship-between-irisin-concentration-and-serum-cytokines-in-mother-and-newborn
#7
Maria Hernandez-Trejo, Gerardo Garcia-Rivas, Alejandro Torres-Quintanilla, Estibalitz Laresgoiti-Servitje
INTRODUCTION: Irisin is considered to be a myokine and adipokine that may also participate in reproductive functions, as it increases significantly throughout pregnancy. However, the regulation of circulating irisin and its relationship with other cytokines has not been assessed thus far in pregnant women and their offspring. OBJECTIVE: The aim of this study was to evaluate differences in irisin and cytokine concentrations between women at the end of pregnancy and their offspring, as well as the relationship between maternal and newborn irisin and maternal and newborn biomarkers...
2016: PloS One
https://www.readbyqxmd.com/read/27815563/association-of-serum-irisin-concentrations-with-presence-and-severity-of-coronary-artery-disease
#8
Wen Deng
BACKGROUND Irisin, an exercise-induced myokine, is closely correlated with obesity and body mass index. Obesity is one risk factor of coronary artery disease (CAD). Therefore, the present study aimed to determine if serum irisin concentrations are correlated with the presence and severity of CAD. MATERIAL AND METHODS Serum irisin concentrations were determined in 350 patients with CAD and in 214 healthy subjects. The severity of CAD was assessed by coronary atherosclerosis index (CAI). RESULTS Serum irisin concentrations were significantly lower in CAD patients compared with healthy controls...
November 5, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27808433/adaptation-of-exercise-induced-stress-in-well-trained-healthy-young-men
#9
Lonneke M JanssenDuijghuijsen, Jaap Keijer, Marco Mensink, Kaatje Lenaerts, Lars Ridder, Stefan Nierkens, Shirley W Kartaram, Martie C M Verschuren, Raymond H H Pieters, Richard Bas, Renger F Witkamp, Harry J Wichers, Klaske van Norren
Strenuous exercise induces different stress-related physiological changes, potentially including changes in intestinal barrier function. In the Protégé Study (ISRCTN14236739; www.isrctn.com) we determined the test-retest repeatability in responses to exercise in well-trained individuals. Eleven well-trained males (27 ± 4 years old) completed an exercise protocol that consisted of intensive cycling intervals, followed by an overnight fast and an additional 90 min cycling phase at 50% Wmax the next morning...
November 3, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27795900/evaluation-of-cord-blood-irisin-levels-in-term-newborns-with-small-gestational-age-and-appropriate-gestational-age
#10
Esengul Keleş, Filiz Fatime Turan
BACKGROUND: Most recently, a novel myokine, named irisin, was identified in human that expressed by skeletal muscle after exercise. Irisin increases energy expenditure by turning white adipose tissue into brown adipose tissue. Thus improves carbohydrate homeostasis in humans. Irisin is considered as a potential biomarker for obesity and metabolic syndrome. In recent years, numerous studies have been conducted about irisin with adults, although number of studies with newborns is limited...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27766246/effects-of-body-weight-reduction-on-serum-irisin-and-metabolic-parameters-in-obese-subjects
#11
Yaeko Fukushima, Satoshi Kurose, Hiromi Shinno, Ha Cao Thi Thu, Nana Takao, Hiromi Tsutsumi, Takaaki Hasegawa, Toshiaki Nakajima, Yutaka Kimura
BACKGROUND: Irisin is a myokine implicated in lipid and glucose metabolism. The objective of this study is to examine the effect of a body weight reduction on the serum irisin level and physical indicators in obese Japanese patients without diabetes. METHODS: The subjects were 22 patients (male/female, 5/17; age, 46.1±16.0 years; body mass index [BMI], 36.9±5.0 kg/m(2)) who completed a 6-month body weight reduction program at our clinic. The program included diet, exercise therapy and cognitive behavioral therapy...
October 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27765498/myokines-and-adipokines-involvement-in-the-crosstalk-between-skeletal-muscle-and-adipose-tissue
#12
Fengna Li, Yinghui Li, Yehui Duan, Chien-An A Hu, Yulong Tang, Yulong Yin
Skeletal muscle and adipose tissue are the two largest organs in the body. Skeletal muscle is an effector organ, and adipose tissue is an organ that stores energy; in addition, they are endocrine organs that secrete cytokines, namely myokines and adipokines, respectively. Myokines consist of myostatin, interleukin (IL)-8, IL-15, irisin, fibroblast growth factor 21, and myonectin; adipokines include leptin, adiponectin, resistin, chemerin, and visfatin. Furthermore, certain cytokines, such as IL-6 and tumor necrosis factor-α, are released by both skeletal muscle and adipose tissue and exhibit a bioactive effect; thus, they are called adipo-myokines...
October 13, 2016: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/27738421/il-15-mediates-mitochondrial-activity-through-a-ppar%C3%AE-dependent-ppar%C3%AE-independent-mechanism-in-skeletal-muscle-cells
#13
Shantaé M Thornton, James E Krolopp, Marcia J Abbott
Molecular mediators of metabolic processes, to increase energy expenditure, have become a focus for therapies of obesity. The discovery of cytokines secreted from the skeletal muscle (SKM), termed "myokines," has garnered attention due to their positive effects on metabolic processes. Interleukin-15 (IL-15) is a myokine that has numerous positive metabolic effects and is linked to the PPAR family of mitochondrial regulators. Here, we aimed to determine the importance of PPARα and/or PPARδ as targets of IL-15 signaling...
2016: PPAR Research
https://www.readbyqxmd.com/read/27726179/association-of-serum-irisin-concentrations-with-the-presence-and-severity-of-obstructive-sleep-apnea-syndrome
#14
Yanli Li, Xueqin Li, Dejun Sun, Shaoxi Cai
OBJECTIVE: Obesity is involved in the pathogenesis of obstructive sleep apnea syndrome (OSAS). Irisin, a recently discovered myokine, protects the mice from obesity. This study aims to determine the association of serum irisin concentrations with the presence and severity of OSAS. METHODS: This cross-sectional investigation was performed in 165 male OSAS patients and 98 healthy male subjects. Serum irisin concentrations were assessed using an enzyme-linked immunosorbent assay kit...
October 11, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27725121/effects-of-exercise-on-irisin-bdnf-and-il-6-serum-levels-in-patients-with-progressive-multiple-sclerosis
#15
Sven Briken, Sina Cathérine Rosenkranz, Oliver Keminer, Stefan Patra, Gesche Ketels, Christoph Heesen, Rainer Hellweg, Ole Pless, Karl-Heinz Schulz, Stefan M Gold
BACKGROUND: Clinical studies have suggested beneficial effects of exercise on cognitive function in ageing adults and neurodegenerative diseases such as dementia. Recent work indicates the same for progressive multiple sclerosis (MS), an inflammatory and degenerative disease of the central nervous system (CNS). The biological pathways associated with these effects are however not well understood. OBJECTIVE: In this randomized controlled study, we explored serum levels of the myokine Irisin, the neurotrophin brain-derived neurotrophic factor (BDNF) and Interleukin-6 (IL-6) during acute endurance exercise and over the course of a 9-weeks endurance exercise training period in n=42 patients with progressive MS...
October 15, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27702700/sarcopenic-obesity-or-obese-sarcopenia-a-cross-talk-between-age-associated-adipose-tissue-and-skeletal-muscle-inflammation-as-a-main-mechanism-of-the-pathogenesis
#16
REVIEW
Alexander Kalinkovich, Gregory Livshits
Sarcopenia, an age-associated decline in skeletal muscle mass coupled with functional deterioration, may be exacerbated by obesity leading to higher disability, frailty, morbidity and mortality rates. In the combination of sarcopenia and obesity, the state called sarcopenic obesity (SOB), some key age- and obesity-mediated factors and pathways may aggravate sarcopenia. This review will analyze the mechanisms underlying the pathogenesis of SOB. In obese adipose tissue (AT), adipocytes undergo hypertrophy, hyperplasia and activation resulted in accumulation of pro-inflammatory macrophages and other immune cells as well as dysregulated production of various adipokines that together with senescent cells and the immune cell-released cytokines and chemokines create a local pro-inflammatory status...
October 1, 2016: Ageing Research Reviews
https://www.readbyqxmd.com/read/27693382/effects-of-physical-exercise-on-myokines-expression-and-brown-adipose-like-phenotype-modulation-in-rats-fed-a-high-fat-diet
#17
Sílvia Rocha-Rodrigues, Amaia Rodríguez, Alexandra M Gouveia, Inês O Gonçalves, Sara Becerril, Beatriz Ramírez, Jorge Beleza, Gema Frühbeck, António Ascensão, José Magalhães
AIMS: Exercise-stimulated myokine secretion into circulation may be related with browning in white adipose tissue (WAT), representing a positive metabolic effect on whole-body fat mass. However, limited information is yet available regarding the impact of exercise on myokine-related modulation of adipocyte phenotype in WAT from obese rats. MAIN METHODS: Sprague-Dawley rats (n=60) were divided into sedentary and voluntary physical activity (VPA) groups and fed with standard (35kcal% fat) or high-fat (HFD, 71kcal% fat)-isoenergetic diets...
November 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/27692156/hypothesis-irisin-is-a-metabolic-trigger-for-the-activation-of-the-neurohormonal-axis-governing-puberty-onset
#18
Fazal Wahab, Muhammad Shahab, Rüdiger Behr
A large body of data suggests that body weight influences puberty onset and adult reproduction. However, the underlying mechanism of how body weight influences puberty onset and fertility is not completely understood. The hypothalamic neuronal circuit regulating reproduction is restrained by inhibitory signals during childhood. At the time of puberty, these inhibitory signals are weakened and supplanted by stimulatory signals that, in turn, stimulate the release of gonadotropin-releasing hormone (GnRH) - a hypothalamic neuropeptide governing reproduction...
October 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27676149/acute-effect-of-cluster-and-traditional-set-configurations-on-myokines-associated-with-hypertrophy
#19
J M Oliver, S C Jenke, J D Mata, A Kreutzer, M T Jones
This study compared the acute cytokine response, and kinetic and kinematic profile following back squat exercise in resistance-trained men. In a randomized, cross-over design, 10 resistance-trained men (27±4 y, 1.80±0.07 m, 82.8±6.7 kg, 16.3±3.5% fat) performed the back squat exercise using traditional and cluster set configurations. Kinetic and kinematic data were sampled throughout each condition. Venous blood was sampled prior, immediately post, 30 min, 60 min, 24 h, and 48 h post-exercise for plasma interleukin-6 (IL-6) and interleukin-15 (IL-15)...
December 2016: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/27671318/irisin-inhibits-atherosclerosis-by-promoting-endothelial-proliferation-through-microrna126-5p
#20
Yuzhu Zhang, Haibo Song, Yuan Zhang, Fei Wu, Qian Mu, Miao Jiang, Fang Wang, Wen Zhang, Liang Li, Lei Shao, Shiwu Li, Lijun Yang, Mingxiang Zhang, Qi Wu, Dongqi Tang
BACKGROUND: Irisin is a newly discovered myokine that has been considered a promising candidate for the treatment of cardiovascular disease through improving endothelial function. However, little is known about the role of irisin in the progression of atherosclerosis. METHODS AND RESULTS: We used a carotid partial ligation model of apolipoprotein E-deficient mice fed on a high-cholesterol diet to test the anti-atherosclerosis effect of irisin. Irisin treatment significantly suppressed carotid neointima formation...
2016: Journal of the American Heart Association
keyword
keyword
24425
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"