keyword
MENU ▼
Read by QxMD icon Read
search

myokine

keyword
https://www.readbyqxmd.com/read/28912874/dietary-vitamin-b6-modulates-the-gene-expression-of-myokines-nrf2-related-factors-myogenin-and-hsp60-in-the-skeletal-muscle-of-rats
#1
Sofya Suidasari, Shinji Uragami, Noriyuki Yanaka, Norihisa Kato
Previous studies have suggested that vitamin B6 is an ergogenic factor. However, the role of dietary vitamin B6 in skeletal muscle has not been widely researched. The aim of the present study was to investigate the effects of dietary vitamin B6 on the gene expression of 19 myokines, 14 nuclear factor erythroid 2-related factor 2 (Nrf2)-regulated factors, 8 myogenesis-related factors and 4 heat shock proteins (HSPs), which may serve important roles in skeletal muscles. Rats were fed a diet containing 1 (marginal vitamin B6 deficiency), 7 (recommended dietary level) or 35 mg/kg of pyridoxine (PN) HCl/ for 6 weeks...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28884429/effects-of-hypergravity-on-gene-levels-in-anti-gravity-muscle-and-bone-through-the-vestibular-system-in-mice
#2
Naoyuki Kawao, Hironobu Morita, Kazuaki Nishida, Koji Obata, Kohei Tatsumi, Hiroshi Kaji
We recently reported that hypergravity with 3 g for 4 weeks affects muscle and bone through the vestibular system in mice. The purpose of this study was to investigate the effects of hypergravity with 2 g, which had no influence on circulating glucocorticoid level, on the gene levels in muscle and bone, as well as the roles of the vestibular system in those changes using vestibular lesioned (VL) mice. Hypergravity for 2 and 8 weeks or VL exerted little effects on the mRNA levels of muscle differentiation factors and myokines in the soleus muscle...
September 7, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/28867187/irisin-stimulates-cell-proliferation-and-invasion-by-targeting-the-pi3k-akt-pathway-in-human-hepatocellular-carcinoma
#3
Guangjun Shi, Nan Tang, Jiantao Qiu, Deguo Zhang, Fei Huang, Yayu Cheng, Kun Ding, Weisheng Li, Ping Zhang, Xueying Tan
Irisin is a newly identified myokine that may be cancer-associated, and its impact on liver cancer is unclear. To understand the roles of irisin in liver cancer, we investigated its effect in HepG2 and SMCC7721 hepatocellular carcinoma cells, and the underlying mechanisms. We determined irisin levels in liver tissues and serum samples obtained from patients by using real-time polymerase chain reaction and enzyme-linked immunosorbent assay. Irisin levels in cancerous livers were significantly upregulated compared with those in control livers, but serum irisin levels remained unchanged...
August 31, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28863832/twenty-five-years-of-cytokine-on-a-forward-path-to-exciting-discoveries-of-pathological-mechanisms-and-therapeutics
#4
EDITORIAL
Dhan V Kalvakolanu
Cytokines, chemokines, adipokines, myokines, and other hematopoietic growth factors constitute the largest network of intercellular signaling proteins that shape organismal development, survival, tissue repair and host defenses. Cytokine has been established for reporting the original research studies in these burgeoning areas. A special issue dedicated to celebrate the quarter century of Cytokine as a journal is here. This review summarizes the contents of several articles published in this special issue.
October 2017: Cytokine
https://www.readbyqxmd.com/read/28861930/electrical-pulse-stimulation-an-in-vitro-exercise-model-for-the-induction-of-human-skeletal-muscle-cell-hypertrophy-a-proof-of-concept-study
#5
Janelle Tarum, Mattias Folkesson, Philip J Atherton, Fawzi Kadi
Electrical Pulse Stimulation (EPS) of muscle cells has previously been used as an in vitro exercise model. The present study aims to establish an EPS protocol promoting the hypertrophy of human muscle cells, which represents a major physiological endpoint to resistance exercise in humans. We hypothesized that adding a resting period after EPS would be critical for the occurrence of the morphological change. Myoblasts obtained from human muscle biopsies (n = 5) were differentiated into multinucleated myotubes and exposed to 8 h EPS consisting of 2 ms pulses at 12 V with a frequency of 1 Hz...
August 31, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28856140/new-insights-about-the-putative-role-of-myokines-in-the-context-of-cardiac-rehabilitation-and-secondary-cardiovascular-prevention
#6
REVIEW
Domenico Di Raimondo, Giuseppe Miceli, Gaia Musiari, Antonino Tuttolomondo, Antonio Pinto
Exercise training prevents the onset and the development of many chronic diseases, acting as an effective tool both for primary and for secondary prevention. Various mechanisms that may be the effectors of these beneficial effects have been proposed during the past decades: some of these are well recognized, others less. Muscular myokines, released during and after muscular contraction, have been proposed as key mediators of the systemic effects of the exercise. Nevertheless the availability of an impressive amount of evidence regarding the systemic effects of muscle-derived factors, few studies have examined key issues: (I) if skeletal muscle cells themselves are the main source of cytokine during exercise; (II) if the release of myokines into the systemic circulation reach an adequate concentration to provide significant effects in tissues far from skeletal muscle; (III) what may be the role carried out by muscular cytokine regarding the well-known benefits induced by regular exercise, first of all the anti-inflammatory effect of exercise...
August 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28856139/measuring-myokines-with-cardiovascular-functions-pre-analytical-variables-affecting-the-analytical-output
#7
REVIEW
Giovanni Lombardi, Veronica Sansoni, Giuseppe Banfi
In the last few years, a growing number of molecules have been associated to an endocrine function of the skeletal muscle. Circulating myokine levels, in turn, have been associated with several pathophysiological conditions including the cardiovascular ones. However, data from different studies are often not completely comparable or even discordant. This would be due, at least in part, to the whole set of situations related to the preparation of the patient prior to blood sampling, blood sampling procedure, processing and/or store...
August 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28856138/role-of-myokines-in-cardiovascular-diseases-and-pre-analytical-variables-affecting-their-measurements
#8
Fabian Sanchis-Gomar
No abstract text is available yet for this article.
August 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28842819/musculoskeletal-health-in-the-context-of-spinal-cord-injury
#9
REVIEW
Jillian M Clark, David M Findlay
PURPOSE OF REVIEW: This review assembles recent understanding of the profound loss of muscle and bone in spinal cord injury (SCI). It is important to try to understand these changes, and the context in which they occur, because of their impact on the wellbeing of SC-injured individuals, and the urgent need for viable preventative therapies. RECENT FINDINGS: Recent research provides new understanding of the effects of age and systemic factors on the response of bone to loading, of relevance to attempts to provide load therapy for bone in SCI...
August 25, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28835761/the-effect-of-n-3-polyunsaturated-fatty-acids-supplementation-on-serum-irisin-in-patients-with-type-2-diabetes-a-randomized-double-blind-placebo-controlled-trial
#10
Samaneh Ansari, Mahmoud Djalali, Niyaz Mohammadzadeh Honarvar, Maryam Mazaherioun, Mahnaz Zarei, Fahimeh Agh, Zahra Gholampour, Mohammad Hassan Javanbakht
BACKGROUND: Diabetes refers to a group of metabolic diseases with blood glucose of higher than normal ranges. Furthermore, n-3 polyunsaturated fatty acids are necessary for the regulation of the activity of human function. The effect of n-3 PUFA on diabetes has been investigated in animal studies, yet, the exact amount has not been set, to date. Irisin, as a new myokine, is released from skeletal muscle and Irisin levels decrease as a result of physical inactivity, overweightness, and obesity...
January 2017: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28828264/exercise-training-with-dietary-restriction-enhances-circulating-irisin-level-associated-with-increasing-endothelial-progenitor-cell-number-in-obese-adults-an-intervention-study
#11
Junhao Huang, Shen Wang, Fengpeng Xu, Dan Wang, Honggang Yin, Qinhao Lai, Jingwen Liao, Xiaohui Hou, Min Hu
OBJECTIVE: Circulating endothelial progenitor cells (EPCs) correlate negatively with obesity. Previous studies have shown that exercise significantly restores circulating EPC levels in obese people; however, the underlying mechanisms have not been elucidated. Recently, irisin has been reported to have a critical role in the regulation of EPCs. This exercise-induced myokine has been demonstrated to play a therapeutic role in obesity. In this study, we hypothesized that the increase in circulating irisin may form a link with increasing EPC levels in obese people after exercise...
2017: PeerJ
https://www.readbyqxmd.com/read/28821817/high-mrna-expression-level-of-il-6r-was-associated-with-better-prognosis-for-patients-with-ovarian-cancer-a-pooled-meta-analysis
#12
Qu Chen, Bin Xu, Lei Lan, Da Yang, Min Yang, Jingting Jiang, Binfeng Lu, Yueping Shen
Interleukin-6 acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. IL-6/IL-6R signaling pathway, in particular, has been proposed to be a pivotal cytokine promoting ovarian cancer progression. This study aimed to elucidate potential clinical and biological function of IL-6R mRNA expression in ovarian cancer. We used the keywords "ovarian cancer" and searched through GEO database and finally a total of 7 studies together with TCGA database were incorporated in this analysis. We used Cutoff Finder to determine a cutoff point and stratified patients into two groups and found that high-expression of IL-6R mRNA in tumor tissues was a positive prognostic factor for overall survival...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28777879/sarcopenia-in-hiding-the-risk-and-consequence-of-underestimating-muscle-dysfunction-in-nash
#13
Rahima A Bhanji, Praveena Narayanan, Alina M Allen, Harmeet Malhi, Kymberly D Watt
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. Up to one third of individuals with NAFLD will develop non-alcoholic steatohepatitis (NASH), which is associated with progression to cirrhosis and is rapidly becoming the leading indication for liver transplantation. Sarcopenia is defined as a progressive and generalized loss of skeletal muscle mass, strength and function. It is seen in up to 60% of patients with end-stage liver disease and portends a poor prognosis...
August 4, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28771499/irisin-regulates-cardiac-physiology-in-zebrafish
#14
Lakshminarasimhan Sundarrajan, Chanel Yeung, Logan Hahn, Lynn P Weber, Suraj Unniappan
Irisin is a myokine encoded in its precursor fibronectin type III domain containing 5 (FNDC5). It is abundantly expressed in cardiac and skeletal muscle, and is secreted upon the activation of peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1 alpha). We aimed to study the role of irisin on cardiac function and muscle protein regulation in zebrafish. Western blot analyses detected the presence of irisin protein (23 kDa) in zebrafish heart and skeletal muscle, and irisin immunoreactivity was detected in both tissues...
2017: PloS One
https://www.readbyqxmd.com/read/28759938/irisin-and-testosterone-in-men-with-metabolic-syndrome
#15
Zdravko Kamenov, Yavor Assyov, Petya Angelova, Antoaneta Gateva, Adelina Tsakova
The beneficial effects of testosterone on the metabolism and body composition of men are well established but the exact mechanisms of these effects are not clearly understood. A potential explanation might lie in the hormones, secreted from skeletal muscles, named "myokines". One such myokine, irisin, has been shown to also have potential beneficial metabolic effects. The aim of this pilot study was to evaluate the association of serum testosterone with circulating serum irisin levels in men with metabolic syndrome...
July 31, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28759185/serum-fgf21-in-girls-with-anorexia-nervosa-comparison-to-normal-weight-and-obese-female-adolescents
#16
Agata Mikolajczak, Joanna M Oswiecimska, Elzbieta Swietochowska, Wojciech Roczniak, Katarzyna T Ziora
BACKGROUND: Fibroblast growth factor 21 (FGF21) is a hepatokine, myokine and adipokine of a potent influence to energy homeostasis. Data according its serum concentrations in AN are contradictory. OBJECTIVES: Analysis of serum FGF21 in girls with acute anorexia nervosa and comparison the results with normal weight and obese female adolescents considering their nutritional status, carbohydrate and lipid metabolism. METHODS: Serum FGF21 concentrations were evaluated using commercially available ELISA kit in 32 Polish girls with restrictive AN (AN), 29 girls with obesity (O) and 21 healthy controls (C)...
July 2, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28744117/alteration-of-the-irisin-brain-derived-neurotrophic-factor-axis-contributes-to-disturbance-of-mood-in-copd-patients
#17
Csaba Papp, Krisztian Pak, Tamas Erdei, Bela Juhasz, Ildiko Seres, Anita Szentpéteri, Laszlo Kardos, Maria Szilasi, Rudolf Gesztelyi, Judit Zsuga
COPD is accompanied by limited physical activity, worse quality of life, and increased prevalence of depression. A possible link between COPD and depression may be irisin, a myokine, expression of which in the skeletal muscle and brain positively correlates with physical activity. Irisin enhances the synthesis of brain-derived neurotrophic factor (BDNF), a neurotrophin involved in reward-related processes. Thus, we hypothesized that mood disturbances accompanying COPD are reflected by the changes in the irisin-BDNF axis...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28733331/n-glycosylation-is-required-for-fdnc5-stabilization-and-irisin-secretion
#18
Yong Wei Nie, Dong Jun Liu
Irisin, a myokine derived from extracellular domain of FNDC5, has been shown to mediate thermogenesis of white adipose tissue. Biochemical data has shown that N-glycosylation of FNDC5 was unlikely to affect ligand or receptor activation of irisin. The N-glycosylation of FNDC5 remains poorly understood. Here, we analyze N-glycosylation sites of FNDC5 and find that two potential N-glycosylation sites (Asn36 and Asn81) could indeed be occupied by N-glycan. We further show that the lack of N-glycosylation decreases the secretion of irisin, which is relevant to the instability of FNDC5 and the deficiency of cleavage of signal peptide...
July 21, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28732566/association-of-circulating-irisin-levels-with-metabolic-and-metabolite-profiles-of-korean-adolescents
#19
Han Byul Jang, Hyo-Jin Kim, Jae Heon Kang, Sang Ick Park, Kyung Hee Park, Hye-Ja Lee
CONTEXT: Irisin, a novel exercise-induced myokine, has been suggested to regulate energy metabolism. OBJECTIVE: We studied the relationship between circulating irisin and metabolic and metabolite profiles of Korean adolescents, and investigated the effects of physical activity, obesity, and metabolic syndrome (MetS) on irisin levels. MATERIALS AND METHODS: Data were obtained from the Korean Children-Adolescents Study. Our cross-sectional study included 618 adolescents (370 normal-weight and 248 obese adolescents; 316 boys and 302 girls) aged 12-15years...
August 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28732565/circulating-irisin-levels-are-lower-in-patients-with-either-stable-coronary-artery-disease-cad-or-myocardial-infarction-mi-versus-healthy-controls-whereas-follistatin-and-activin-a-levels-are-higher-and-can-discriminate-mi-from-cad-with-similar-to-ck-mb-accuracy
#20
Athanasios D Anastasilakis, Dimitrios Koulaxis, Nikoleta Kefala, Stergios A Polyzos, Jagriti Upadhyay, Eirini Pagkalidou, Fotios Economou, Chrysostomos D Anastasilakis, Christos S Mantzoros
BACKGROUND: Several myokines are produced by cardiac muscle. We investigated changes in myokine levels at the time of acute myocardial infarction (MI) and following reperfusion in relation to controls. METHODS: Patients with MI (MI Group, n=31) treated with percutaneous coronary intervention (PCI) were compared to patients with stable coronary artery disease (CAD) subjected to scheduled PCI (CAD Group, n=40) and controls with symptoms mimicking CAD without stenosis in angiography (Control Group, n=43)...
August 2017: Metabolism: Clinical and Experimental
keyword
keyword
24425
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"