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Red yeast rice

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https://www.readbyqxmd.com/read/28093797/adverse-reactions-to-dietary-supplements-containing-red-yeast-rice-assessment-of-cases-from-the-italian-surveillance-system
#1
G Mazzanti, P A Moro, E Raschi, R Da Cas, F Menniti-Ippolito
BACKGROUND AND AIM: Red yeast rice (RYR) is contained in dietary supplements used in patients with dyslipidemia. RYR supplements contain monacolin K, which is chemically identical to lovastatin, a licensed drug with a well-known risk profile. We aimed to describe the safety profile of RYR by analysing spontaneous reports of suspected adverse reactions (ARs). METHODS: Within the Italian Surveillance System of Natural Health Products, suspected ARs were collected and evaluated by a multidisciplinary group of experts to assess causality using the WHO-UMC system or the CIOMS/RUCAM score, for hepatic reactions...
January 17, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28058034/retrospective-analysis-of-the-effects-of-a-highly-standardized-mixture-of-berberis-aristata-silybum-marianum-and-monacolins-k-and-ka-in-patients-with-dyslipidemia
#2
Francesco Di Pierro, Pietro Putignano, Tarcisio Ferrara, Carmela Raiola, Giuliana Rapacioli, Nicola Villanova
BACKGROUND: Berberis aristata, because of its berberine content, and Monascus purpureus fermented rice, because of the presence of monacolins (naturally derived statins), are widely investigated food-grade ingredients used to formulate cholesterol-lowering supplements. Although they are extensively used, berberine is poorly absorbed and monacolins are poorly chemically characterized, not standardized, and possibly contaminated with toxic compounds. Silymarin is reported to enhance berberine absorption, while Monakopure™-K20 (MK-20) is a highly standardized red yeast rice containing monacolins K and KA in the ratio of 1:1 but not secondary monacolins, dehydromonacolins, or citrinin...
2017: Clinical Pharmacology: Advances and Applications
https://www.readbyqxmd.com/read/28054118/-red-yeast-rice-an-unsafe-food-supplement
#3
Christian Steffen
Red yeast rice is the fermentation product of the mould Monascus ruber and is traditionally used in East Asia to dye and conserve food. Its main pharmacologically active compound, monakolin K, was isolated from red yeast rice and is used as an inhibitor of cholesterol synthesis under the INN lovastatin. Lovastatin and several other statins are marketed as drugs whereas red yeast rice is offered as a food supplement. As statins can cause severe side effects, such as muscle damage and kidney failure, the dosing and information about interactions with drugs and food is essential for the use of these products...
January 4, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28026946/monascustin-an-unusual-%C3%AE-lactam-from-red-yeast-rice
#4
Wendi Wei, Sheng Lin, Minghua Chen, Tianxi Liu, Ali Wang, Jinjie Li, Qinglan Guo, Xiaoya Shang
Monascustin (1), an unusual γ-lactam, was isolated from an ethanol extract of the Monascus purpureus fermented rice. Its structure including the absolute configuration was determined by spectroscopic data analysis and confirmed by X-ray crystallography. A plausible biosynthetic pathway is discussed on the basis of amino acid derivatization. Compound 1 showed inhibitory activity against histone deacetylase 1.
December 27, 2016: Journal of Natural Products
https://www.readbyqxmd.com/read/27998714/a-nutraceutical-approach-armolipid-plus-to-reduce-total-and-ldl-cholesterol-in-individuals-with-mild-to-moderate-dyslipidemia-review-of-the-clinical-evidence
#5
Vivencio Barrios, Carlos Escobar, Arrigo Francesco Giuseppe Cicero, David Burke, Peter Fasching, Maciej Banach, Eric Bruckert
Compelling evidence supports the effectiveness of the reduction of total and LDL cholesterol (TC and LDL-C) in primarily preventing cardiovascular events, within the framework of life-long prevention programs mainly consisting in lifestyle changes. Pharmacological treatment should be introduced when lifestyle changes, including use of nutraceuticals, have failed. ESC/EAS guidelines list a number of nutraceutical compounds and functional foods which have been individually studied in randomized, controlled clinical trials (RCTs)...
February 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/27956024/joint-position-statement-on-nutraceuticals-for-the-treatment-of-hypercholesterolemia-of-the-italian-society-of-diabetology-sid-and-of-the-italian-society-for-the-study-of-arteriosclerosis-sisa
#6
REVIEW
M Pirro, C Vetrani, C Bianchi, M R Mannarino, F Bernini, A A Rivellese
AIM: Evidence showed that LDL-cholesterol lowering is associated with a significant cardiovascular risk reduction. The initial therapeutic approach to hypercholesterolemia includes dietary modifications but the compliance to recommendations is often inadequate. Some dietary components with potential cholesterol-lowering activity are present in small amounts in food. Therefore, in recent years the use of "nutraceuticals" (i.e., nutrients and/or bioactive compounds with potential beneficial effects on human health) has become widespread...
January 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/27902524/red-yeast-rice-the-efficacy-of-monascus-purpureus-yeast-for-treatment-of-hyperlipidemia-a-modifiable-risk-factor-of-cardiovascular-disease
#7
Stephanie Maxine Ross
No abstract text is available yet for this article.
January 2017: Holistic Nursing Practice
https://www.readbyqxmd.com/read/27882320/mediterrasian-diet-products-that-could-raise-hdl-cholesterol-a-systematic-review
#8
REVIEW
Mariangela Rondanelli, Attilio Giacosa, Paolo Morazzoni, Davide Guido, Mario Grassi, Gabriella Morandi, Chiara Bologna, Antonella Riva, Pietro Allegrini, Simone Perna
Background. High HDL-cholesterol (HDL-C) values are negatively correlated with cardiovascular diseases. This review analyses the effect of the supplementation with various Mediterranean diet products (artichoke, bergamot, and olive oil) and Asian diet products (red yeast rice) on the HDL-C value in dyslipidemic subjects. Methods. A systematic review has been done involving all the English written studies published from the 1st of January 1958 to the 31st of March 2016. Results. The results of this systematic review indicate that the dietary supplementation with red yeast rice, bergamot, artichoke, and virgin olive oil has promising effects on the increase of HDL-C serum levels...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27865358/low-daily-dose-of-3-mg-monacolin-k-from-ryr-reduces-the-concentration-of-ldl-c-in-a-randomized-placebo-controlled-intervention
#9
Tina Heinz, Jan Philipp Schuchardt, Katharina Möller, Peyman Hadji, Andreas Hahn
Hypercholesterolemia and elevated homocysteine concentrations are associated with cardiovascular risk. Previous studies have demonstrated a cholesterol-lowering effect of red yeast rice (RYR) supplements which contained 5 to 10 mg of monacolin K. We hypothesized that the intake of a low monacolin K dose may likewise reduce low-density lipoprotein-cholesterol (LDL-C) and other plasma lipids. In secondary analyses, we tested the homocysteine lowering effect of folic acid, which was also included in the study preparation...
October 2016: Nutrition Research
https://www.readbyqxmd.com/read/27673001/poster-244-an-unusual-cause-of-coma-from-consumption-of-red-yeast-rice-a-case-report
#10
Yogen Patel, Alex B Behar, Chirag D Shah, Ravi E Kasi
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27649148/molecular-and-biochemical-analysis-of-two-rice-flavonoid-3-hydroxylase-to-evaluate-their-roles-in-flavonoid-biosynthesis-in-rice-grain
#11
Sangkyu Park, Min Ji Choi, Jong Yeol Lee, Jae Kwang Kim, Sun-Hwa Ha, Sun-Hyung Lim
Anthocyanins and proanthocyanidins, the major flavonoids in black and red rice grains, respectively, are mainly derived from 3',4'-dihydroxylated leucocyanidin. 3'-Hydroxylation of flavonoids in rice is catalyzed by flavonoid 3'-hydroxylase (F3'H: EC 1.14.13.21). We isolated cDNA clones of the two rice F3'H genes (CYP75B3 and CYP75B4) from Korean varieties of white, black, and red rice. Sequence analysis revealed allelic variants of each gene containing one or two amino acid substitutions. Heterologous expression in yeast demonstrated that CYP75B3 preferred kaempferol to other substrates, and had a low preference for dihydrokaempferol...
September 13, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27508588/-op-8e-07-middle-term-dietary-supplementation-with-red-yeast-rice-plus-coenzyme-q10-improves-lipid-pattern-endothelial-reactivity-and-arterial-stiffness-in-moderately-hypercholesterolemics
#12
A F G Cicero, M Morbini, M Rosticci, S D'addato, E Grandi, C Borghi
OBJECTIVE: Red yeast rice is a well-known lipid-lowering nutraceutical. The aim of this double-blind, randomized, placebo-controlled, clinical trial was to investigate if the known benefits on lipid pattern of a 6-month treatment with 10 mg monacolins could be also associated to changes in endothelial function and arterial stiffness. DESIGN AND METHOD: This double blind, placebo-controlled, randomized clinical trial was carried out on 40 moderately hypercholesterolemic subjects, non smokers, pharmacologically untreated, in primary prevention for cardiovascular diseases (Clinicaltrial...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27467559/the-effect-of-dietary-replacement-of-ordinary-rice-with-red-yeast-rice-on-nutrient-utilization-enteric-methane-emission-and-rumen-archaeal-diversity-in-goats
#13
L Z Wang, M L Zhou, J W Wang, D Wu, T Yan
Twenty castrated Boer crossbred goats were used in the present study with two treatments to examine the effect of dietary replacement of ordinary rice with red yeast rice on nutrient utilization, enteric methane emission and ruminal archaea structure and composition. Two treatment diets contained (DM basis) 70.0% of forage, 21.8% of concentrates and 8.2% of either ordinary rice (control) or red yeast rice (RYR). Nutrient utilization was measured and enteric methane emissions were determined in respiration chambers...
2016: PloS One
https://www.readbyqxmd.com/read/27438400/-red-yeast-rice-as-a-cholesterol-lowering-substance-caution-is-warranted
#14
J R B J Brouwers, J E Roeters van Lennep, A H E M Maas
- In various non-medical publications, red yeast rice (red fermented rice, RYR) is recommended as a cholesterol-lowering substance. This supplement contains a naturally occurring statin, namely monacolin K.- Patients who wish to use RYR should be advised to only take products from reputable pharmaceutical companies. Pharmacists can provide advice on this.- Users of RYR should be alerted to the potential drug interactions and serious risks associated with its use during pregnancy.- RYR appears to be better tolerated than statins...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27339779/effects-of-a-combined-nutraceutical-on-lipid-pattern-glucose-metabolism-and-inflammatory-parameters-in-moderately-hypercholesterolemic-subjects-a-double-blind-cross-over-randomized-clinical-trial
#15
Arrigo Francesco Giuseppe Cicero, Alessandro Colletti, Federica Fogacci, Marilisa Bove, Martina Rosticci, Claudio Borghi
BACKGROUND: There is an increasing interest for combined nutraceuticals that can act on several points of lipid and glucose metabolism with preventive purposes. However, the simple assemblage of nutraceuticals with potentially additive mechanism of action need to be clinically tested. METHODS: To assess the effects of a combination of nutraceuticals based on artichoke, red yeast rice, banaba, and coenzyme Q10, we performed a double bind, cross-over designed trial versus placebo in 30 adults with LDL cholesterol suboptimal in primary prevention of cardiovascular disease...
June 23, 2016: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/27328902/analysis-of-citrinin-in-cereals-red-yeast-rice-dietary-supplement-and-animal-feed-by-immunoaffinity-column-cleanup-and-lc-with-fluorescence-detection
#16
Elaine Marley, Phyllis Brown, Dave Leeman, Carol Donnelly
The analysis of citrinin in various cereals (wheat, oats, maize, rice, and rye and multigrain breakfast cereal), red yeast rice (dietary supplement and traditional medicine), distillers dried grain with solubles, and barley (animal feed) was carried out using a citrinin immunoaffinity column (IAC) for sample cleanup before LC analysis with fluorescence detection (LC-fluorescence). To establish method performance characteristics, wheat was spiked with citrinin at levels of 10-200 μg/kg, whereas red yeast rice was spiked at levels of 100-3000 μg/kg...
July 2016: Journal of AOAC International
https://www.readbyqxmd.com/read/27234467/homeopathy-for-depression-music-for-postoperative-recovery-red-yeast-rice-for-high-cholesterol-acupuncture-for-seasonal-allergic-rhinitis-and-ginger-for-osteoarthritis
#17
Richard Glickman-Simon, Craig Schneider
No abstract text is available yet for this article.
July 2016: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/27229865/neurospora-crassa-tox-1-gene-encodes-a-ph-and-temperature-tolerant-mini-cellulase
#18
Yue Xiao, Qiongsi Zhang, Yiquan Luo, Ying Zhang, Xi Luo, Yuchuan Wang, Weiguo Cao, Vito De Pinto, Qiuyun Liu, Gang Li
Cellulases that endure extreme conditions are essential in various industrial sectors. This study reports a mini-cellulase gene tox-1 from Neurospora crassa. The gene tox-1 was cloned in Escherichia coli after chimerization with the YebF gene and substitutions of certain isoleucine and valine with leucine residues. The yeast transformants could grow on rice straw-agar medium. The 44-amino acid peptide and its two mutant variants displayed potent cellulase activities in Congo Red assay and enzymatic assays. Conservative replacements with leucine have substantially increased the stabilities and half-lives of the peptides at alkaline pH and low and high temperatures and also the tolerance to organic solvents and surfactants, on the basis of activities toward cellose...
June 15, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27190793/effect-of-red-yeast-rice-and-coconut-rice-bran-or-sunflower-oil-combination-in-rats-on-hypercholesterolemic-diet
#19
Sumitra Govindarajan, Kishore Vellingiri
INTRODUCTION: Dietary supplements provide a novel population based health approach for treating hyperlipidemias. Red yeast rice is known to have lipid lowering effects. Combination of red yeast rice with various oils is taken by different population around the world. AIM: In this present work, we aimed to compare the effects of red yeast rice with different oil (coconut, rice bran and sunflower oil) supplementations on lipid levels and oxidative stress in rats fed on hypercholesterolemic diet...
April 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27175514/additional-therapy-for-cholesterol-lowering-in-ezetimibe-treated-statin-intolerant-patients-in-clinical-practice-results-from-an-internal-audit-of-a-university-lipid-clinic
#20
Arrigo F G Cicero, Martino Morbini, Marilisa Bove, Sergio D'Addato, Federica Fogacci, Martina Rosticci, Claudio Borghi
OBJECTIVE: The aim of our study was to evaluate the tolerability and efficacy of alternative approaches to improve cholesterolemia control in patients with statin-related myalgia treated with ezetimibe. RESEARCH DESIGN AND METHODS: We retrospectively evaluated 3534 Clinical Report Forms (CRFs) filled in the period June 2012-June 2015 for first visits to the lipid clinic of the University of Bologna. For this study, we selected 252 CRFs based on the following criteria: statin-related myalgia, previous failed treatment with at least two low-dosed statins, well-tolerated treatment with ezetimibe...
May 13, 2016: Current Medical Research and Opinion
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