Jieping Liu, Wanbo Li, Sujie Sun, Ling Huang, Mengqi Wan, Xue Li, Li Zhang, Dou Yang, Fasheng Liu, Xinjun Liao, Huiqiang Lu, Juhua Xiao, Shouhua Zhang, Zigang Cao
Four tyrosine kinase inhibitors, alectinib, apatinib, lenvatinib and anlotinib, have been shown to be effective in the treatment of clinical tumors, but their cardiac risks have also raised concerns. In this study, zebrafish embryos at 6 h post fertilization (hpf) were exposed to the four drugs at concentrations of 0.05-0.2 mg/L until 72 hpf, and then the development of these embryos was quantified, including heart rate, body length, yolk sac area, pericardial area, distance between venous sinus and balloon arteriosus (SV-BA), separation of cardiac myocytes and endocardium, gene expression, vascular development and oxidative stress...
January 11, 2024: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP