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https://www.readbyqxmd.com/read/27878778/elevated-serum-levels-of-ghrelin-and-tnf-%C3%AE-in-patients-with-cyanotic-and-acyanotic-congenital-heart-disease
#1
Sai Zhang, Gong-Liang Guo, Li-Li Yang, Li-Qun Sun
BACKGROUND: The levels of ghrelin and tumor necrosis factor alpha (TNF-α) are considered biological markers of congenital heart diseases (CHD). The present meta-analysis was conducted to investigate the clinical significance of serum levels of ghrelin and TNF-α in children with (CHD). METHODS: Chinese and English scientific literature databases were searched to retrieve published studies relevant to ghrelin, TNF-α and CHD. Manual search was additionally employed to identify other relevant studies from cross-references...
November 23, 2016: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/27831548/a-novel-more-efficient-staged-approach-for-critical-congenital-heart-disease-screening
#2
J Mouledoux, S Guerra, J Ballweg, Y Li, W Walsh
OBJECTIVE: Screening for critical congenital heart disease (CCHD) using pulse oximetry has been endorsed by the American Academy of Pediatrics and the American Heart Association. The recommended screening requires two saturation readings. We sought to determine the incidence of undetected CCHD in Tennessee for the 2 years following implementation of an algorithm that assigned an immediate pass to a single lower extremity saturation of 97% or higher. STUDY DESIGN: State Genetic Screening records and reports of missed cases from the Tennessee Initiative for Perinatal Quality Care were used to determine if CCHD cases were missed by the new screening algorithm...
November 10, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27799231/electrophysiology-study-for-complex-supraventricular-tachycardia-in-congenital-heart-disease-patients-with-single-ventricle-physiology
#3
Shuenn-Nan Chiu, Jou-Kou Wang, Chun-Wei Lu, Kun-Lang Wu, Wei-Chieh Tseng, Mei-Hwan Wu
BACKGROUND: Supraventricular tachycardia (SVT) is common in complex congenital heart disease (CCHD) patients with single-ventricle physiology and may cause hemodynamic deterioration. We reported the outcomes of catheter ablation for such complex SVT in these single-ventricle CCHD patients. METHODS AND RESULTS: Patients with single-ventricle physiology (defined as CCHD patients) who received electrophysiology studies and catheter ablation between 1995 and 2015 were studied...
October 31, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27739239/critical-congenital-heart-defects-and-abnormal-levels-of-routinely-collected-first-and-second-trimester-biomarkers
#4
Melissa Borelli, Rebecca J Baer, Christina D Chambers, Tyler C Smith, Laura L Jelliffe-Pawlowski
We examined the association between maternal characteristics, routinely collected first- and second-trimester biomarkers and the risk of having an infant with a critical congenital heart defect (CCHD). Included were women who participated in the California Prenatal Screening Program who had nuchal translucency (NT) measurement and first- and second-trimester serum screening. All pregnancies ended in a live birth of an infant without aneuploidy or a neural tube defect. Poisson regression analyses were used to estimate the relative risk and 95% confidence interval of a CCHD by maternal characteristics, first- and second-trimester serum biomarkers or NT measurements...
October 14, 2016: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/27699992/combined-analysis-of-cross-reacting-antibodies-anti-%C3%AE-1ar-and-anti-b13-in-advanced-stages-of-chagas-heart-disease
#5
Luz M Rodeles, Miguel H Vicco, Iván A Bontempi, Alvaro Siano, Georgina Tonarelli, Oscar A Bottasso, Pablo Arias, Iván S Marcipar
OBJECTIVE: Autoantibodies cross-reacting with the β1 adrenergic receptor (anti-β1AR and anti-p2β) and cardiac myosin antigens (anti-B13) have been related to the pathogenesis of chronic Chagas heart disease (CCHD). Studies exploring their levels in different stages are scarce. We aimed to evaluate the relationship of these autoantibodies with the clinical profile of chronic patients, especially regarding their classificatory accuracy in severe presentation with heart failure. METHODS AND RESULTS: We conducted a cross-sectional study of 155 T...
December 2016: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/27603538/newborn-critical-congenital-heart-disease-screening-using-pulse-oximetry-nursing-aspects
#6
Lisa A Hom, Gerard R Martin
Congenital heart disease (CCHD) is the most common birth defect. Screening for the most critical forms (CCHD) using pulse oximetry was added to the Recommended Uniform Screening Panel in the United States in 2011. Since then, CCHD screening has become nearly universal in the United States. Nurses are ideally situated to contribute to the development of best practices for implementation and provide education to families on CCHD screening. Much of the standardization, advocacy, and development of national recommendations occurred with key input from nurses...
September 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27603536/screening-for-critical-congenital-heart-defects-with-pulse-oximetry-medical-aspects
#7
Andrew K Ewer
The detection of newborn babies with potentially life-threatening, critical congenital heart defects (CCHDs) before they collapse or expire remains an important clinical challenge. The absence of physical signs and the difficulty assessing mild cyanosis means that the newborn baby check misses up to a third of babies. Fetal anomaly ultrasound scanning identifies an increasing proportion, but this screen is operator-dependent and therefore highly variable; although some units report very high detection rates, overall most babies with CCHD are still missed...
September 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27583398/pulse-oximetry-screening-for-critical-congenital-heart-disease-in-planned-out-of-hospital-births-and-the-incidence-of-critical-congenital-heart-disease-in-the-plain-community
#8
K K Miller, K S Vig, E M Goetz, G Spicer, A J Yang, J S Hokanson
OBJECTIVE: This study evaluated pulse oximetry screening (POS) for critical congenital heart disease (CCHD) in planned out of hospital births with special attention to births in Plain communities (Amish, Mennonite and similar). STUDY DESIGN: Wisconsin out of hospital births in 2013 and 2014 were evaluated. Care providers were supplied with and trained in the use of pulse oximeters for CCHD screening. State records were reviewed to identify deaths and hospital admissions due to CCHD in this population...
December 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27530240/newborn-pulse-oximetry-screening-in-practice
#9
Abdul Qader Tahir Ismail, Matt Cawsey, Andrew K Ewer
The concept of using pulse oximetry (PO) as a screening test to identify newborn babies with critical congenital heart defects (CCHD) before life-threatening collapse occurs has been debated for some time now. Several recent large studies have consistently shown that PO screening adds value to existing screening techniques with over 90% of CCHDs detected. It can also help identify newborn babies with low oxygen saturations due to infection, respiratory disease and non-critical CCHD. Many countries have now introduced PO screening as routine practice, and as screening gains more widespread acceptance in the UK, we have focused more on the practical aspects of screening in this article...
August 16, 2016: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/27499412/feasibility-of-pulse-oximetry-pre-discharge-screening-implementation-for-detecting-critical-congenital-heart-lesions-in-newborns-in-a-secondary-level-maternity-hospital-in-the-western-cape-south-africa-the-popsicle-study
#10
A M Van Niekerk, R M Cullis, L L Linley, L Zühlke
BACKGROUND: Early detection of critical congenital heart disease (CCHD) through newborn pulse oximetry (POx) screening is an effective strategy for reducing paediatric morbidity and mortality rates and has been adopted by much of the developed world. OBJECTIVES: To document the feasibility of implementing pre-discharge POx screening in well babies born at Mowbray Maternity Hospital, a busy government hospital in Cape Town, South Africa. Parent and staff acceptance was assessed...
August 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27491102/implementing-universal-pulse-oximetry-screening-in-west-virginia-findings-from-year-one
#11
Collin John, John Phillips, Candice Hamilton, Allison Lastliger
BACKGROUND: In March 2012 the West Virginia legislature passed a law that mandates birth hospitals to perform pulse oximetry screening for all well-babies in the newborn nursery to improve the detection of critical congenital heart disease (CCHD). CCHD screening data collection began on September 1, 2012 at all 28 birthing hospitals. The purpose of this study was to review the first year of pulse oximetry screening outcomes and identify barriers to implementation and solutions to improve tracking and policy...
July 2016: West Virginia Medical Journal
https://www.readbyqxmd.com/read/27390667/critical-congenital-heart-disease-screening
#12
REVIEW
Mohammed A Chamsi-Pasha, Hassan Chamsi-Pasha
Critical congenital heart disease (CCHD) is a heart lesion for which neonates require early surgical intervention to survive. Without intervention, the rates of mortality and survival with significant disability are extremely high. Early diagnosis can potentially improve health outcomes in newborns with CCHD. Until recent years, no routine screening protocol existed. In the last few years, pulse oximetry screening for CCHD in newborns has been added to the list of recommended uniform screening panels and advocated by several health-care authorities...
July 2016: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/27377063/quantification-by-real-time-pcr-of-trypanosoma-cruzi-dna-in-samples-of-triatoma-infestans-used-in-xenodiagnosis-of-chronic-chagas-disease-patients
#13
Miguel Saavedra, Inés Zulantay, Werner Apt, Juan Castillo, Eduardo Araya, Gabriela Martínez, Jorge Rodríguez
BACKGROUND: Trypanosoma cruzi multiplies and differentiates in the digestive tract of triatomine insects. Xenodiagnosis (XD) is a parasitological tool in which the insect vectors acts as a biological culture medium to amplify and detect T. cruzi infection in mammals. The sensitivity of XD has been overcome by the application of PCR in fecal samples (FS) of XD (PCR-XD). In this study, T. cruzi amplified in Triatoma infestans fed by XD on individuals with chronic Chagas disease (CChD) is quantified by real-time PCR (qPCR-XD)...
2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27279759/universal-pulse-oximetry-screening-for-early-detection-of-critical-congenital-heart-disease
#14
REVIEW
Praveen Kumar
Critical congenital heart disease (CCHD) is a major cause of infant death and morbidity worldwide. An early diagnosis and timely intervention can significantly reduce the likelihood of an adverse outcome. However, studies from the United States and other developed countries have shown that as many as 30%-50% of infants with CCHD are discharged after birth without being identified. This diagnostic gap is likely to be even higher in low-resource countries. Several large randomized trials have shown that the use of universal pulse-oximetry screening (POS) at the time of discharge from birth hospital can help in early diagnosis of these infants...
2016: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/27244826/lessons-learned-from-newborn-screening-for-critical-congenital-heart-defects
#15
Matthew E Oster, Susan W Aucott, Jill Glidewell, Jesse Hackell, Lazaros Kochilas, Gerard R Martin, Julia Phillippi, Nelangi M Pinto, Annamarie Saarinen, Marci Sontag, Alex R Kemper
Newborn screening for critical congenital heart defects (CCHD) was added to the US Recommended Uniform Screening Panel in 2011. Within 4 years, 46 states and the District of Columbia had adopted it into their newborn screening program, leading to CCHD screening being nearly universal in the United States. This rapid adoption occurred while there were still questions about the effectiveness of the recommended screening protocol and barriers to follow-up for infants with a positive screen. In response, the Centers for Disease Control and Prevention partnered with the American Academy of Pediatrics to convene an expert panel between January and September 2015 representing a broad array of primary care, neonatology, pediatric cardiology, nursing, midwifery, public health, and advocacy communities...
May 2016: Pediatrics
https://www.readbyqxmd.com/read/27223644/carlos-chagas-discoveries-as-a-drop-back-to-scientific-construction-of-chronic-chagas-heart-disease
#16
Reinaldo B Bestetti, Carolina Baraldi A Restini, Lucélio B Couto
The scientific construction of chronic Chagas heart disease (CCHD) started in 1910 when Carlos Chagas highlighted the presence of cardiac arrhythmia during physical examination of patients with chronic Chagas disease, and described a case of heart failure associated with myocardial inflammation and nests of parasites at autopsy. He described sudden cardiac death associated with arrhythmias in 1911, and its association with complete AV block detected by Jacquet's polygraph as Chagas reported in 1912. Chagas showed the presence of myocardial fibrosis underlying the clinical picture of CCHD in 1916, he presented a full characterization of the clinical aspects of CCHD in 1922...
July 2016: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/27160097/pediatric-resident-attitudes-and-knowledge-of-critical-congenital-heart-disease-screening
#17
Ashish Garg, Anshul Arora, Ivan L Hand
This study aimed to understand the knowledge, attitudes and confidence level related to critical congenital heart disease (CCHD) screening among pediatric residents. Pediatric residents were assessed via an anonymous survey related to CCHD guidelines and procedures as set out by the New York State Department of Health. The survey was emailed to pediatric residents at a large academic institution. A teaching intervention was performed after the initial survey, which was followed by an identical after-intervention survey...
August 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27073996/development-of-a-newborn-screening-program-for-critical-congenital-heart-disease-cchd-in-taipei
#18
Pei-Chen Tsao, Yu-Shih Shiau, Szu-Hui Chiang, Hui-Chen Ho, Yu-Ling Liu, Yuan-Fang Chung, Li-Ju Lin, Ming-Ren Chen, Jia-Kan Chang, Wen-Jue Soong, Hsiu-Lian Lin, Betau Hwang, Kwang-Jen Hsiao
BACKGROUND: Early detection of critical congenital heart disease (CCHD) can significantly reduce morbidity and mortality among newborns. We investigate the feasibility of implementing a community-based newborn CCHD screening program in Taipei. METHODS: Twelve birthing facilities in Taipei participated in a trial screening program between October 1, 2013, and March 31, 2014. Newborns underwent pulse oximetry at 24-36 h old, with probes attached to the right hand and one lower limb...
2016: PloS One
https://www.readbyqxmd.com/read/27052073/serum-albumin-perturbations-in-cyanotics-after-cardiac-surgery-patterns-and-predictions
#19
Poonam Malhotra Kapoor, Jitin Narula, Ujjwal Kumar Chowdhury, Usha Kiran, Sameer Taneja
INTRODUCTION: Hypoalbuminemia is a well-recognized predictor of general surgical risk and frequently occurs in patients with cyanotic congenital heart disease (CCHD). Moreover, cardiopulmonary bypass (CPB)-induced an inflammatory response, and the overall surgical stress can effect albumin concentration greatly. The objective of his study was to track CPB-induced changes in albumin concentration in patients with CCHD and to determine the effect of hypoalbuminemia on postoperative outcomes...
April 2016: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/27008492/the-potential-influence-of-atherogenic-dyslipidemia-on-the-severity-of-chronic-chagas-heart-disease
#20
Luz Peverengo, Luz Rodeles, Miguel Hernan Vicco, Iván Marcipar
INTRODUCTION: chronic Chagas heart disease (CCHD) is the most common manifestation of American Trypanosomiasis, causing about 50,000 deaths annually. Several factors bear correlation with the severity of CCHD. However, to our knowledge, the assessment on the contribution of major cardiovascular risk factors (CRF), such as hypertension and atherogenic dyslipidemia (AD) to CCHD severity is scarce, despite their well-established role in coronary artery disease, heart failure and stroke. OBJECTIVE: to explore the potential relationship of blood pressure and AD with the clinical profile of patients with CCHD...
January 2016: Revista da Associação Médica Brasileira
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