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https://www.readbyqxmd.com/read/28091911/biocompatibility-of-modified-osteoinductive-calcium-phosphate-coatings-of-metal-implants
#1
T S Zaporozhets, A V Puz', S L Sinebryukhov, S V Gnedenkov, T P Smolina, N N Besednova
The cellular and molecular aspects of immunological compatibility of modified osteoinductive calcium-phosphate coatings formed on technically pure titanium VT1-0 by the plasma electrolytic oxidation technology are studied. The technique of coating modified the process of human peripheral blood leukocyte activation in vitro. The most pronounced functional changes were observed in neutrophil population during whole blood contact with titanium sample without coating and with coating formed by plasma electrolytic oxidation on titanium alloy...
January 14, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28091865/improving-the-diagnostic-workup-of-hyponatremia-in-the-setting-of-kidney-disease-a-continuing-medical-education-cme-initiative
#2
Ladan Golestaneh, Joel Neugarten, William Southern, Faraj Kargoli, Amanda Raff
PURPOSE: Hyponatremia is a common electrolyte disorder and is associated with mortality. We examined the frequency of appropriate testing in response to an episode of inpatient hyponatremia in a large urban hospital to better inform our educational intervention. We then evaluated the impact of a live CME activity with a focus on CKD- and ESRD-associated hyponatremia physiology, on diagnostic practices of audience hospitalist attendings. METHODS: We performed a retrospective database analysis of all patients admitted to Montefiore Medical Center in 2014 to examine the performance of hospital staff in response to hyponatremia across all CKD stages...
January 13, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28091628/in-situ-x-ray-absorption-near-edge-structure-studies-and-charge-transfer-kinetics-of-na6-v10o28-electrodes
#3
Han-Yi Chen, Jochen Friedl, Chun-Jern Pan, Ali Haider, Rami Al-Oweini, Yan Ling Cheah, Ming-Hsien Lin, Ulrich Kortz, Bing-Joe Hwang, Madhavi Srinivasan, Ulrich Stimming
Polyoxometalates (POMs) have been reported as promising electrode materials for energy storage applications due to their ability to undergo fast redox reactions with multiple transferred electrons per polyanion. Here we employ a polyoxovanadate salt, Na6[V10O28], as an electrode material in a lithium-ion containing electrolyte and investigate the electron transfer properties of Na6[V10O28] on long and short timescales. Looking at equilibrated systems, in situ V K-edge X-ray absorption near edge structure (XANES) studies show that all 10 V(5+) ions in Na6[V10O28] can be reversibly reduced to V(4+) in a potential range of 4-1...
January 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28090765/aggregation-kinetics-of-diesel-soot-nanoparticles-in-wet-environments
#4
Chengyu Chen, Weilin Huang
Soot produced during incomplete combustion consists mainly of carbonaceous nanoparticles (NPs) with severe adverse environmental and health effects, and its environmental fate and transport are largely controlled by aggregation. In this study, we examined the aggregation behavior for diesel soot NPs under aqueous condition in an effort to elucidate the fundamental processes that govern soot particle-particle interactions in wet environments such as rain droplets or surface aquatic systems. The influence of electrolytes and aqueous pH on colloidal stability of these NPs was investigated by measuring their aggregation kinetics in different aqueous solution chemistries...
January 16, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28090568/pathophysiology-of-intestinal-na-h-exchange
#5
Michael A Gurney, Daniel Laubitz, Fayez K Ghishan, Pawel R Kiela
Several members of the SLC9A family of Na(+)/H(+) exchangers are expressed in the gut, with varying expression patterns and cellular localization. Not only do they participate in the regulation of basic epithelial cell functions, including control of transepithelial Na(+) absorption, intracellular pH (pH i ), cell volume, and nutrient absorption, but also in cellular proliferation, migration, and apoptosis. Additionally, they modulate the extracellular milieu in order to facilitate other nutrient absorption and to regulate the intestinal microbial microenvironment...
January 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28090366/bosutinib-therapy-in-patients-with-chronic-myeloid-leukemia-practical-considerations-for-management-of-side-effects
#6
REVIEW
Patricia S Ault, John Rose PharmD, Lisa A Nodzon PhD, Elizabeth S Kaled
The past decade has witnessed great advances in the treatment of chronic myeloid leukemia (CML), brought about in large part by the development of BCR-ABL tyrosine kinase inhibitors (TKIs). Bosutinib joins the armamentarium of approved TKIs for the treatment of chronic phase (CP), accelerated phase (AP), and blast phase (BP) Philadelphia chromosome (Ph)-positive CML resistant to or intolerant of prior therapy. Bosutinib has an adverse-event (AE) profile distinct from that of other TKIs. Diarrhea is the predominant toxicity associated with bosutinib treatment; other commonly reported nonhematologic AEs include rash and liver enzyme elevations...
March 2016: Journal of the Advanced Practitioner in Oncology
https://www.readbyqxmd.com/read/28090048/hyponatremia-in-an-elderly-patient-due-to-isolated-hypoaldosteronism-occurring-after-licorice-withdrawal
#7
Yuji Hataya, Akifumi Oba, Takafumi Yamashita, Yasato Komatsu
Hyponatremia is one of the most common electrolyte disorders encountered in the elderly. We present the case of an 81-year-old man who developed hyponatremia due to isolated hypoaldosteronism occurring after licorice withdrawal. He had severe hypokalemia with hypertension and was diagnosed with pseudoaldosteronism. He had been taking a very small dose of licorice as a mouth refresher since his early adulthood. Five months after licorice withdrawal, he developed hypovolemic hyponatremia, which was resolved with administration of fludrocortisone acetate...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28089738/evaluation-of-the-diuretic-activity-of-the-aqueous-and-80-methanol-extracts-of-the-root-of-euclea-divinorum-hiern-ebenaceae-in-sprague-dawley-rats
#8
Beharu Woldemedhin, Teshome Nedi, Workineh Shibeshi, Mekonnen Sisay Shiferaw
BACKGROUND: Diuretics are drugs that increase the formation of urine and are important for the treatment of various diseases including hypertension and edema. The root decoction of Euclea divinorum has been used as a diuretic agent in the traditional medicine. Therefore, this study was aimed to evaluate the diuretic activity of the crude extracts of the roots of Euclea divinorum in Sprague Dawley rats. METHODS: The aqueous extract (AE) and 80% methanol extract (80ME) of the plant were prepared using decoction and maceration, respectively...
January 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28088853/the-formation-of-ti-h-species-at-interface-is-lethal-to-the-efficiency-of-tio2-based-dye-sensitized-devices
#9
Yan Yan, Weidong Shi, Zhen Yuan, Shenggui He, Dongmei Li, Qingbo Meng, Hongwei Ji, Chuncheng Chen, Wanhong Ma, Jincai Zhao
TiO2-based dye-sensitization cycle is one of the basic strategies for the development of solar energy applications. Although the power conversion efficiency (PCE) of dye-sensitized devices has been improved through constant attempts, the intrinsically fatal factor that leads to the complete failure of the PCE of TiO2-mediated dye-sensitized devices has not yet been determined. Here, by using isotopically labeled MAS-1H NMR, ATR-FTIR spectroscopy (separate H/D and 48Ti/49Ti experiments) and ESR, we revealed that the accumulative formation of Ti-H species on the TiO2 surface is the intrinsic cause of the PCE failure of TiO2-based dye-sensitization devices...
January 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28088475/role-of-some-vasoactive-mediators-in-scorpion-envenomed-children-possible-relation-to-envenoming-outcome
#10
Sahar E M El-DeeK, Ayat A Sayed, Ahmed Y Nassar, Zeynab M Mohey-Eldeen, Hussein M Eldeeb, Abdel-Raheim M A Meki
Scorpion envenomation causes an autonomic storm resulting in changes in the vasoactive mediators' levels which lead to myocardial damage, cardiovascular disturbances, peripheral circulatory failure, pulmonary edema, multi-system-organ-failure and death. The study aimed to determine the circulating levels of adrenaline, noradrenaline, angiotensin converting enzyme (ACE), Angiotensin II (Ang II), kallikrein enzyme, nitric oxide (NO), aldosterone, and electrolytes Na(+), K(+) and Ca(+2) in scorpion envenomed children and to evaluate the potential relation between these vasoactive mediators, the severity of scorpion envenoming and the clinical outcome of envenomed children...
January 11, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28088017/co-delivery-of-ibuprofen-and-gentamicin-from-nanoporous-anodic-titanium-dioxide-layers
#11
Anna Pawlik, Magdalena Jarosz, Karolina Syrek, Grzegorz D Sulka
Although single-drug therapy may prove insufficient in treating bacterial infections or inflammation after orthopaedic surgeries, complex therapy (using both an antibiotic and an anti-inflammatory drug) is thought to address the problem. Among drug delivery systems (DDSs) with prolonged drug release profiles, nanoporous anodic titanium dioxide (ATO) layers on Ti foil are very promising. In the discussed research, ATO samples were synthesized via a three-step anodization process in an ethylene glycol-based electrolyte with fluoride ions...
January 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28087893/brompheniramine-as-a-novel-probe-for-indirect-uv-detection-and-its-application-for-the-capillary-electrophoresis-of-adamantane-drugs
#12
Pornpan Prapatpong, Brompoj Prutthiwanasan, Nantana Nuchtavorn, Sawanya Buranaphalin, Leena Suntornsuk
Brompheniramine, an antihistamine drug, was employed as a novel UV probe for capillary electrophoresis with indirect UV detection of adamantane drugs (memantine, amantadine, and rimantadine). The probe possesses high molar absorptivity of 24 × 10(3) L/mol cm at 6 mM, which enables the measurement of these non-chromophore analytes without derivatization. The simple background electrolyte (10 mM sodium dihydrogen phosphate (pH 5.0) containing 5 mM brompheniramine and 6 mM β-cyclodextrin) provided the separation of the analytes in a short time (7...
January 14, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28087222/revisiting-the-refeeding-syndrome-results-of-a-systematic-review
#13
Natalie Friedli, Zeno Stanga, Lubos Sobotka, Alison Culkin, Jens Kondrup, Alessandro Laviano, Beat Mueller, Philipp Schuetz
OBJECTIVE: Although described >70 y ago, the refeeding syndrome (RFS) remains understudied with lack of standardized definition and treatment recommendations. The aim of this systematic review was to gather evidence regarding standardized definition, incidence rate and time course of occurrence, association with adverse clinical outcomes, risk factors, and therapeutic strategies to prevent or treat this condition. METHODS: We searched MEDLINE and EMBASE for interventional and observational clinical trials focusing on RFS, excluding case reports and reviews...
June 8, 2016: Nutrition
https://www.readbyqxmd.com/read/28085732/effectiveness-of-probiotics-in-reducing-the-incidence-of-clostridium-difficile-associated-diarrhea-in-elderly-patients-a-systematic-review
#14
Marina Vernaya, Jennifer McAdam, Michelle DeCoux Hampton
BACKGROUND: Clostridium difficile bacteria are a leading cause of infectious diarrhea. This is an anaerobic, gram-positive and spore-forming rod responsible for significant morbidity and mortality, especially among elderly hospitalized patients. Standard management of C. difficile-associated diarrhea (CDAD) consists of discontinuing a causative antibiotic, correcting fluid-electrolytes imbalance and initiating an antibiotic treatment for CDAD. Alternative approaches for prevention of CDAD include probiotics...
January 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28085545/methadone-inpatient-and-discharge-prescribing-patterns-for-pain-at-an-academic-health-system
#15
Rabia S Atayee, Gene H Hur, Parisa Karimian, Kathy A Hollenbach, Kyle P Edmonds
BACKGROUND: Methadone is effective for the treatment of chronic pain, but its unique pharmacology requires additional considerations with dosing and monitoring. OBJECTIVE: The study objective was to evaluate methadone prescribing for pain and subsequent monitoring. METHODS: This retrospective chart review at a single center reviewed patients who received methadone over a two-year period. RESULTS: Of the 100 patients, most were noncancer cases (60%) with unspecified pain (50%)...
February 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28085376/modes-of-electrokinetic-instability-for-imperfect-electric-membranes
#16
G S Ganchenko, E N Kalaydin, J Schiffbauer, E A Demekhin
The direct transition to overlimiting current bypassing the stage of limiting currents is considered for imperfect membranes. Instability of the quiescent steady-state one-dimensional solution, which is the result of a balance of diffusion and electromigration, is investigated on the basis of the full Nernst-Planck-Poisson-Stokes system and a simplified quasielectroneutral system. A three-layer geometry, electrolyte-porous membrane-electrolyte, is considered. The usual assumption of a constant electrochemical potential along the membrane surface is removed from consideration...
December 2016: Physical Review. E
https://www.readbyqxmd.com/read/28085302/anisotropic-macroturbulence-and-diffusion-associated-with-a-westward-zonal-jet-from-laboratory-to-planetary-atmospheres-and-oceans
#17
Boris Galperin, Jesse Hoemann, Stefania Espa, Gabriella Di Nitto, Guglielmo Lacorata
Turbulence with inverse energy cascade and its transport properties are investigated experimentally in a flow associated with a westward propagating jet. Turbulence and the jet were produced by an electromagnetic force in a rotating tank filled with an electrolytic saline solution. The parabolic free surface emulated the topographic β effect which evoked the zonation. The spectral and transport flow characteristics were highly anisotropic. Turbulence is diagnosed by exploring the analogy between vertical and horizontal turbulent overturns in, respectively, stably stratified and quasigeostrophic flows which gives rise to a method of potential vorticity (PV) monotonizing...
December 2016: Physical Review. E
https://www.readbyqxmd.com/read/28084733/application-of-ionic-liquids-to-energy-storage-and-conversion-materials-and-devices
#18
Masayoshi Watanabe, Morgan L Thomas, Shiguo Zhang, Kazuhide Ueno, Tomohiro Yasuda, Kaoru Dokko
Ionic liquids (ILs) are liquids consisting entirely of ions and can be further defined as molten salts having melting points lower than 100 °C. One of the most important research areas for IL utilization is undoubtedly their energy application, especially for energy storage and conversion materials and devices, because there is a continuously increasing demand for clean and sustainable energy. In this article, various application of ILs are reviewed by focusing on their use as electrolyte materials for Li/Na ion batteries, Li-sulfur batteries, Li-oxygen batteries, and nonhumidified fuel cells and as carbon precursors for electrode catalysts of fuel cells and electrode materials for batteries and supercapacitors...
January 13, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28084724/is-the-solid-electrolyte-interphase-an-extra-charge-reservoir-in-li-ion-batteries
#19
S J Rezvani, Roberto Gunnella, Agnieszka Witkowska, Franziska Mueller, Marta Pasqualini, Francesco Nobili, Stefano Passerini, Andrea Di Cicco
Advanced metal oxide electrodes in Li-ion batteries usually show reversible capacities exceeding the theoretically expected ones. Despite many studies and tentative interpretations, the origin of this extra capacity is not assessed yet. Lithium storage can be increased through different chemical processes developing in the electrodes during charging cycles. The solid electrolyte interface (SEI), formed already during the first lithium uptake, is usually considered to be a passivation layer preventing the oxidation of the electrodes while not participating in the lithium storage process...
January 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28084512/design-of-experiments-for-amino-acid-extraction-from-tobacco-leaves-and-their-subsequent-determination-by-capillary-zone-electrophoresis
#20
Ondřej Hodek, Tomáš Křížek, Pavel Coufal, Helena Ryšlavá
In this study, we optimized a method for the determination of free amino acids in Nicotiana tabacum leaves. Capillary electrophoresis with contactless conductivity detector was used for the separation of 20 proteinogenic amino acids in acidic background electrolyte. Subsequently, the conditions of extraction with HCl were optimized for the highest extraction yield of the amino acids because sample treatment of plant materials brings some specific challenges. Central composite face-centered design with fractional factorial design was used in order to evaluate the significance of selected factors (HCl volume, HCl concentration, sonication, shaking) on the extraction process...
January 13, 2017: Analytical and Bioanalytical Chemistry
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