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https://www.readbyqxmd.com/read/28634649/assessment-of-cabozantinib-treatment-on-qt-interval-in-a-phase-3-study-in-medullary-thyroid-cancer-evaluation-of-indirect-qt-effects-mediated-through-treatment-induced-changes-in-serum-electrolytes
#1
Dale R Miles, Steven A Lacy, David R Wada, Steve Milwee, Yifah Yaron, Linh T Nguyen
PURPOSE: This study evaluated factors impacting QTc interval in a phase 3 trial of cabozantinib in progressive, metastatic, medullary thyroid cancer (MTC). METHODS: Electrocardiogram (12-lead ECG) measurements were obtained at screening, and at pre-dose, and 2, 4, and 6 h post-dose on Days 1 and 29 in a phase 3 study in patients with MTC treated with cabozantinib (140 mg/day). Central tendency analyses were conducted on baseline-corrected QTc values. Linear and nonlinear mixed-effects models were used to evaluate potential factors affecting the QTc interval, including serum electrolytes, patient demographics, and cabozantinib concentration...
June 20, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28631789/electrolyte-effect-in-induced-charge-electroosmosis
#2
Huicheng Feng, Yi Huang, Teck Neng Wong, Fei Duan
This paper reports an interesting phenomenon that the velocity increases with increasing sodium chloride (NaCl) concentration in induced charge electroosmosis (ICEO) around a conducting cylinder measured by microparticle image velocimetry (μPIV). It is different from the widely reported velocity decay with increasing electrolyte concentration in AC electroosmosis (ACEO) [M. Z. Bazant et al., MicroTAS, 2007, 2875-2878] and induced charge electrophoresis (ICEP) of Janus particles [S. Gangwal et al., Phys. Rev...
June 20, 2017: Soft Matter
https://www.readbyqxmd.com/read/28631401/a-polyacrylamide-hydrogel-electrolyte-enabled-intrinsically-1000-stretchable-and-50-compressible-supercapacitor
#3
Yan Huang, Ming Zhong, Fukuan Shi, Xiaoying Liu, Zijie Tang, Yukun Wang, Yang Huang, Haoqing Hou, Xuming Xie, Chunyi Zhi
Stretchability and compressibility of supercapacitors constitute essential elements of modern electronics such as flexible and wearable devices. Widely-used polyvinyl alcohol-based electrolytes are neither very stretchable nor compressible, which fundamentally limit the realization of high stretchability and compressibility of supercapacitors. We present a new electrolyte that is intrinsically super-stretchable and compressible. Vinyl hybrid silica nanoparticle cross-linkers are introduced into polyacrylamide hydrogel backbones to promote dynamic crosslinking of the polymer networks...
June 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28631393/comparison-of-thiazide-like-diuretics-versus-thiazide-type-diuretics-a-meta-analysis
#4
REVIEW
Wenjing Liang, Hui Ma, Luxi Cao, Wenjiang Yan, Jingjing Yang
Thiazide diuretics are widely used for the management of hypertension. In recent years, it has been actively debated that there is interchangeability of thiazide-type diuretics hydrochlorothiazide and thiazide-like diuretics including indapamide and chlorthalidone for the treatment of hypertension. With the purpose of seeking out the best thiazide diuretic for clinicians, we summarized the existing evidence on the two types of drugs and conducted a meta-analysis on their efficacy in lowering blood pressure and effects on blood electrolyte, glucose and total cholesterol...
June 19, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28631132/adaptive-biochemical-and-physiological-responses-of-eriobotrya-japonica-to-fluoride-air-pollution
#5
Nada Elloumi, Mohamed Zouari, Imed Mezghani, Ferjani Ben Abdallah, Steve Woodward, Monem Kallel
The biochemical and physiological effects of fluoride were investigated in loquat trees (Eriobotrya japonica) grown in the vicinity of a phosphate fertilizer plant in Tunisia. Photosynthetic rate (Pn), stomatal conductance (Gs), transpiration rate (E), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities were assessed; along with photosynthetic pigments, lipid peroxidation, electrolytic leakage (EL) and total phenolic contents in foliage and roots of trees at different distances from the phosphate fertilizer plant...
June 19, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28630457/how-impaired-efficacy-happened-between-gancao-and-yuanhua-compounds-targets-and-pathways
#6
Jin-Gao Yu, Jianming Guo, Kevin Yue Zhu, Weiwei Tao, Yanyan Chen, Pei Liu, Yongqing Hua, Yuping Tang, Jin-Ao Duan
As recorded in Traditional Chinese Medicine (TCM) theory, Gancao (Glycyrrhizae Radix et Rhizoma) could weaken the pharmacological effect or increase the toxicity of Yuanhua (Genkwa Flos). However, the theory has been suspected due to lack of evidence. Here, we investigate whether Gancao could weaken Yuanhua's diuretic effect, if so, which chemicals and which targets may be involved. Results showed that Yuanhua exerted diuretic effect through down-regulating renal AQP 2, without electrolyte disturbances such as K(+) loss which has been observed as side-effect of most diuretics...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28630451/electronic-band-alignment-at-complex-oxide-interfaces-measured-by-scanning-photocurrent-microscopy
#7
J H Yoon, H J Jung, J T Hong, Ji-Yong Park, Soonil Lee, S W Lee, Y H Ahn
The band alignment at an Al2O3/SrTiO3 heterointerface forming a two-dimensional electron gas (2DEG) was investigated using scanning photocurrent microscopy (SPCM) in an electrolyte-gated environment. We used a focused UV laser source for above-the-bandgap illumination on the SrTiO3 layer, creating electron-hole pairs that contributed to the photocurrent through migration towards the metal electrodes. The polarity of the SPCM signals of a bare SrTiO3 device shows typical p-type behavior at zero gate bias, in which the photogenerated electrons are collected by the electrodes...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28630253/cold-induced-thermogenesis-and-inflammation-associated-cold-seeking-behavior-are-represented-by-different-dorsomedial-hypothalamic-sites-a-three-dimensional-functional-topography-study-in-conscious-rats
#8
Samuel P Wanner, M Camila Almeida, Yury P Shimansky, Daniela L Oliveira, Justin R Eales, Cândido C Coimbra, Andrej A Romanovsky
In the past, we showed that large electrolytic lesions of the dorsomedial hypothalamus (DMH) promoted hypothermia in cold-exposed restrained rats, but attenuated hypothermia in rats challenged with a high dose of bacterial lipopolysaccharide (LPS) in a thermogradient apparatus. The goal of this study was to identify the thermoeffector mechanisms and DMH representation of the two phenomena and, hence, understand how the same lesion could produce two opposite effects on body temperature. We found that the permissive effect of large electrolytic DMH lesions on cold-induced hypothermia was due to suppressed thermogenesis...
June 19, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28630246/ominous-triad-triggered-by-high-dose-glucocorticosteroid-therapy
#9
Sarah Bär, Fritz Daudel, Thomas Zueger
Glucocorticosteroids (CS) play a key role in the treatment of numerous diseases. Nonetheless, they can be accompanied by several adverse effects. We present the case of a 51-year-old woman who was treated with high-dose CS for a relapse of her multiple sclerosis. After 5 days of treatment, the patient developed severe diabetic ketoacidosis, hypertriglyceridemia and acute pancreatitis-a potentially life-threatening triad which has previously been described, in our case, however, for the first time as a complication of CS therapy...
June 18, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28629075/fabrication-of-chitosan-au-tio2-nanotube-based-dry-electrodes-for-electroencephalography-recording
#10
Yanjuan Song, Penghai Li, Mingji Li, Hongji Li, Cuiping Li, Dazhi Sun, Baohe Yang
In this paper, we describe a method for fabricating dry electrodes for use in recording electroencephalograms (EEGs), which are based on the use of chitosan (Ch), gold (Au) particles, and titanium dioxide (TiO2) nanotube arrays deposited on titanium (Ti) thin sheets. The samples were characterized by scanning electron microscopy, X-ray diffraction, electrochemical impedance spectroscopy, and EEG signal collection. The TiO2 nanotube arrays were grown on the Ti thin sheet by an electrochemical anodic oxidation method...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628995/in-simulated-body-fluid-performance-of-polymorphic-apatite-coatings-synthesized-by-pulsed-electrodeposition
#11
Shoujie Liu, Hejun Li, Leilei Zhang, Xuemin Yin, Yao Guo
Surface modification is to modify biological responses through changing surface properties without reducing the mechanical properties of the implant. Specifically bioactive coatings, such as hydroxyapatite, carbonate apatite and dicalcium phosphate dehydrate, have been deposited on carbon/carbon (C/C) composites to change the bio-inert surface state. This work focused on the effects of voltages and electrolyte concentrations of pulsed electrodeposition on apatite layer. The apatite coatings thus synthesized were then structurally, morphologically and chemically characterized using X-ray diffraction, scanning electron microscopy, Transmission electron microscopy and Fourier-transform infrared spectroscopy...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628846/substance-p-and-the-neurokinin-1-receptor-expression-in-dog-ileum-with-and-without-inflammation
#12
Giulia Polidoro, Fiorella Giancola, Federico Fracassi, Marco Pietra, Giuliano Bettini, Martina Asti, Roberto Chiocchetti
In the gastrointestinal tract, the tachykinin Substance P (SP) is involved in motility, fluid and electrolyte secretion, and blood flow and regulation of immunoinflammatory response. SP exerts its biological activity on target cells by interacting mainly with the neurokinin-1 receptor (NK1R). The present study aims to quantify the percentage of SP-immunoreactive (SP-IR) enteric neurons and the density of SP-IR nerve fibers in the ileum of control dogs (CTRL-dogs; n=7) vs dogs with spontaneous ileal inflammation (INF-dogs; n=8)...
June 12, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28628326/improved-sodium-ion-storage-performance-of-ultrasmall-iron-selenide-nanoparticles
#13
Feipeng Zhao, Sida Shen, Liang Cheng, Lu Ma, Junhua Zhou, Hualin Ye, Na Han, Tianpin Wu, Yanguang Li, Jun Lu
Sodium-ion batteries are potential low-cost alternatives to current lithium-ion technology, yet their performance still fall short of expectation due to the lack of suitable electrode materials with large capacity, long-term cycling stability and high-rate performance. In this work, we demonstrated that ultrasmall (~5 nm) iron selenide (FeSe2) nanoparticles exhibited a remarkable performance for sodium-ion storage. They were prepared from a high-temperature solution method with a narrow size distribution and high yield, and could be readily redispersed in non-polar organic solvents...
June 19, 2017: Nano Letters
https://www.readbyqxmd.com/read/28628316/soft-sphere-continuum-solvation-in-electronic-structure-calculations
#14
Giuseppe Fisicaro, Luigi Genovese, Oliviero Andreussi, Sagarmoy Mandal, Nisanth N Nair, Nicola Marzari, Stefan Goedecker
We present an implicit solvation approach where the interface between the quantum-mechanical solute and the surrounding environment is described by a fully continuous permittivity built up with atomic-centered ``soft'' spheres. This approach combines many of the advantages of the self-consistent continuum solvation model in handling solutes and surfaces in contact with complex dielectric environments or electrolytes in electronic-structure calculations. In addition it is able to describe accurately both neutral and charged systems...
June 19, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28628293/one-step-device-fabrication-of-phosphorene-and-graphene-interdigital-micro-supercapacitors-with-high-energy-density
#15
Han Xiao, Zhong-Shuai Wu, Long Chen, Feng Zhou, Shuanghao Zheng, Wencai Ren, Hui-Ming Cheng, Xinhe Bao
Rational engineering and simplified fabrication of high-energy micro-supercapacitors (MSCs) using graphene and other 2D nanosheets are of great value for flexible and integrated electronics. In this work, we develop one-step mask-assisted simplified fabrication of high-energy MSCs based on the interdigital hybrid electrode (PG) patterns of stacking high quality phosphorene nanosheets and electrochemically exfoliated graphene in ionic liquid electrolyte (denoted as PG-MSCs). The hybrid PG films with interdigital patterns were directly manufactured by layer-by-layer deposition of phosphorene and graphene nanosheets with the assistance of a customized interdigital mask, and directly transferred onto a flexible substrate...
June 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/28628239/recent-progress-on-advanced-materials-for-solid-oxide-fuel-cells-operating-below-500-%C3%A2-c
#16
REVIEW
Yuan Zhang, Ruth Knibbe, Jaka Sunarso, Yijun Zhong, Wei Zhou, Zongping Shao, Zhonghua Zhu
Solid-oxide fuel cells (SOFCs) are electricity generators that can convert the chemical energy in various fuels directly to the electric power with high efficiency. Recent advances in materials and related key components for SOFCs operating at ≈500 °C are summarized here, with a focus on the materials, structures, and techniques development for low-temperature SOFCs, including the analysis of most of the critical parameters affecting the electrochemical performance of the electrolyte, anode, and cathode...
June 19, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28628121/universal-quinone-electrodes-for-long-cycle-life-aqueous-rechargeable-batteries
#17
Yanliang Liang, Yan Jing, Saman Gheytani, Kuan-Yi Lee, Ping Liu, Antonio Facchetti, Yan Yao
Aqueous rechargeable batteries provide the safety, robustness, affordability, and environmental friendliness necessary for grid storage and electric vehicle operations, but their adoption is plagued by poor cycle life due to the structural and chemical instability of the anode materials. Here we report quinones as stable anode materials by exploiting their structurally stable ion-coordination charge storage mechanism and chemical inertness towards aqueous electrolytes. Upon rational selection/design of quinone structures, we demonstrate three systems that coupled with industrially established cathodes and electrolytes exhibit long cycle life (up to 3,000 cycles/3,500 h), fast kinetics (≥20C), high anode specific capacity (up to 200-395 mAh g(-1)), and several examples of state-of-the-art specific energy/energy density (up to 76-92 Wh kg(-1)/ 161-208 Wh l(-1)) for several operational pH values (-1 to 15), charge carrier species (H(+), Li(+), Na(+), K(+), Mg(2+)), temperature (-35 to 25 °C), and atmosphere (with/without O2), making them a universal anode approach for any aqueous battery technology...
June 19, 2017: Nature Materials
https://www.readbyqxmd.com/read/28627770/electrochemically-powered-energy-conserving-carbon-nanotube-artificial-muscles
#18
Jae Ah Lee, Na Li, Carter S Haines, Keon Jung Kim, Xavier Lepró, Raquel Ovalle-Robles, Seon Jeong Kim, Ray H Baughman
While artificial muscle yarns and fibers are potentially important for many applications, the combination of large strokes, high gravimetric work capacities, short cycle times, and high efficiencies are not realized for these fibers. This paper demonstrates here electrochemically powered carbon nanotube yarn muscles that provide tensile contraction as high as 16.5%, which is 12.7 times higher than previously obtained. These electrochemical muscles can deliver a contractile energy conversion efficiency of 5...
June 19, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28627732/the-acute-effect-of-loperamide-on-ileostomy-output-a-randomized-double-blinded-placebo-controlled-cross-over-study
#19
Katrine Kristensen, Niels Qvist
High stoma output is a common problem in patients with ileostomy and can lead to dehydration and electrolyte disturbances. The first drug of choice to reduce stoma output is often loperamide. The aim was to assess the acute effect of loperamide on (a) ileostomy output in g/day, (b) gastrointestinal transit time and (c) patient-reported effects. A total of 12 patients completed this double-blinded, randomized, placebo-controlled, cross-over study, consisting of a 3-day treatment period with loperamide 12 mg/day or placebo followed by the reverse after a washout period of 5-7 days...
June 19, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28627573/surface-specific-vibrational-spectroscopy-of-the-water-silica-interface-screening-and-interference
#20
Jan Schaefer, Grazia Gonella, Mischa Bonn, Ellen H G Backus
Surface-specific vibrational sum-frequency generation spectroscopy (V-SFG) is frequently used to obtain information about the molecular structure at charged interfaces. Here, we provide experimental evidence that not only screening of surface charges but also interference limits the extent to which V-SFG probes interfacial water at sub-mM salt concentrations. As a consequence, V-SFG yields information about the ∼single monolayer interfacial region not only at very high ionic strength, where the surface charge is effectively screened, but also for pure water due to the particularly large screening length at this low ionic strength...
June 19, 2017: Physical Chemistry Chemical Physics: PCCP
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