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https://www.readbyqxmd.com/read/29145044/image-processing-for-precise-three-dimensional-registration-and-stitching-of-thick-high-resolution-laser-scanning-microscopy-image-stacks
#1
Chloé Murtin, Carole Frindel, David Rousseau, Kei Ito
The possible depth of imaging of laser-scanning microscopy is limited not only by the working distances of objective lenses but also by image degradation caused by attenuation and diffraction of light passing through the specimen. To tackle this problem, one can either flip the sample to record images from both sides of the specimen or consecutively cut off shallow parts of the sample after taking serial images of certain thickness. Multiple image substacks acquired in these ways should be combined afterwards to generate a single stack...
November 8, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29143108/immune-checkpoint-inhibitor-colitis-the-flip-side-of-the-wonder-drugs
#2
Naziheh Assarzadegan, Elizabeth Montgomery, Robert A Anders
Immune checkpoint inhibitors block the co-inhibitory receptors on T cells to activate their cytotoxic immune function and are rapidly being explored for the treatment of various advanced-stage malignancies. These novel drugs have already significantly increased survival rates. The first available immune checkpoint inhibitors were cytotoxic T lymphocyte antigen 4 (CTLA-4) inhibitors (such as ipilimumab), followed by programmed cell death protein 1 (PD-1) and programmed cell death protein ligand 1 (PD-L1) inhibitors (such as pembrolizumab and nivolumab)...
November 15, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29141882/transparent-anemone-shrimp-ancylomenes-pedersoni-become-opaque-after-exercise-and-physiological-stress-in-correlation-with-increased-hemolymph-perfusion
#3
Laura E Bagge, Stephen T Kinsey, Justin Gladman, Sönke Johnsen
Whole-body transparency, an effective camouflage strategy in many aquatic species, can be disrupted by environmental and/or physiological stressors. We found that tail-flip escape responses temporarily disrupt the transparency of the anemone shrimp Ancylomenes pedersoni After as few as three tail flips, the previously transparent abdominal muscle became cloudy. Eliciting additional tail flips to the point of exhaustion (16±1 s.e.m.; n=23) resulted in complete opacity, though the original transparency returned after 20-60 min of inactivity...
November 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29137334/the-coffee-diterpene-kahweol-enhances-sensitivity-to-sorafenib-in-human-renal-carcinoma-caki-cells-through-down-regulation-of-mcl-1-and-c-flip-expression
#4
Kyoung-Jin Min, Hee Jung Um, Jee In Kim, Taeg Kyu Kwon
Sorafenib is approved for the treatment of hepatocellular carcinoma (HCC) and advanced renal cell carcinoma (RCC). However, low tumor response and side effects have been widely reported. Therefore, to improve the efficacy of sorafenib, we investigated whether combined treatment with sorafenib and kahweol, the coffee-specific diterpene, has a synergistic effect on apoptotic cell death. Combined treatment with sorafenib and kahweol markedly induced caspase-mediated apoptosis in renal carcinoma Caki cells. Combined treatment with sorafenib and kahweol induced down-regulation of Mcl-1 and c-FLIP expression...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29134576/comparing-speech-and-nonspeech-context-effects-across-timescales-in-coarticulatory-contexts
#5
Navin Viswanathan, Damian G Kelty-Stephen
Context effects are ubiquitous in speech perception and reflect the ability of human listeners to successfully perceive highly variable speech signals. In the study of how listeners compensate for coarticulatory variability, past studies have used similar effects speech and tone analogues of speech as strong support for speech-neutral, general auditory mechanisms for compensation for coarticulation. In this manuscript, we revisit compensation for coarticulation by replacing standard button-press responses with mouse-tracking responses and examining both standard geometric measures of uncertainty as well as newer information-theoretic measures that separate fast from slow mouse movements...
November 13, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/29126404/correction-to-flipping-for-success-evaluating-the-effectiveness-of-a-novel-teaching-approach-in-a-graduate-level-setting
#6
John Moraros, Adiba Ashrafi, Stan Yu, Ryan Banow, Barbara Schindelka
Following publication of the original article [1], author 2 pointed out that his name has since changed from Adiba Islam to Adiba Ashrafi.
November 10, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29126032/human-myeloma-igg4-reveals-relatively-rigid-asymmetric-y-like-structure-with-different-conformational-stability-of-ch2-domains
#7
Vladimir M Tischenko, Zav'yalov Vladimir P, Sergey N Ryazantsev
Human IgG4 (hIgG4) has weak pro-inflammatory activity. The structural basis for this is still unclear. Here a 3D model of myeloma hIgG4 was created at ∼3nm resolution using electron microscopy (EM) with negative staining and single-particle 3D reconstruction. The hIgG4 model reveals relatively rigid asymmetric Y-like structure. The model shows that one Fab subunit is closer to the upper portion of the Fc subunit (CH2 domain) than the other Fab. This is in agreement with X-ray crystallography and X-ray/neutron scattering, recently published by others...
November 7, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29121561/flip-an-assisting-software-in-structure-based-drug-design-using-fingerprint-of-protein-ligand-interaction-profiles
#8
Ali Hajiebrahimi, Younes Ghasemi, Amirhossein Sakhteman
With the growing number of labor-intensive data in the pharmaceutical industries and public domain for protein-ligand complexes, a significant challenge is still remaining in managing and leveraging this vast information. Here, a standalone application is presented for analysis, organization, and illustration of structural data and molecular interactions for exploiting 3D-structures into simple 1D fingerprints. The utility of the approach was shown in unraveling a feasible solution for post-processing of docking results in parallel with providing fruitful analysis for users in order to investigate molecular interactions...
November 1, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29121512/composite-pulse-and-partially-dipolar-dephased-multicp-for-improved-quantitative-solid-state-13-c-nmr
#9
Pu Duan, Klaus Schmidt-Rohr
Improved multiple cross polarization (multiCP) pulse sequences for quickly acquiring quantitative (13)C NMR spectra of organic solids are presented. Loss of (13)C magnetization due to imperfect read-out and storage pulses in multiCP has been identified as a significant mechanism limiting polarization enhancement for (13)C sites with weak couplings to (1)H. This problem can be greatly reduced by composite 90° pulses with non-orthogonal phases that flip the magnetization onto the spin-lock field and back to the longitudinal direction for the (1)H repolarization period; the observed loss is <3% for over ±10 kHz resonance offset and up to 20% flip-angle error...
November 6, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29120528/student-performance-in-a-flipped-classroom-dental-anatomy-course
#10
S Chutinan, C A Riedy, S E Park
PURPOSE: The purpose of this study was to assess dental student learning in a dental anatomy module between traditional lecture and flipped classroom cohorts. METHODS: Two cohorts of predoctoral dental students (N = 70 within each cohort) participated in a dental anatomy module within an Introduction to the Dental Patient (IDP) course ([traditional/lecture cohort: academic year (AY) 2012, 2013] and [flipped classroom cohort: AY 2014, 2015]). For the dental anatomy module, both cohorts were evaluated on pre-clinical tooth waxing exercises immediately after each of five lectures and tooth identification after all lectures were given...
November 9, 2017: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/29119783/dense-aligned-copper-nanowire-composites-as-high-performance-thermal-interface-materials
#11
Michael Thomas Barako, Scott G Isaacson, Feifei Lian, Eric Pop, Reinhold H Dauskardt, Kenneth E Goodson, Jesse Tice
Thermal interface materials (TIMs) are essential for managing heat in modern electronics, and nanocomposite TIMs can offer critical improvements. Here we demonstrate thermally conductive, mechanically-compliant TIMs based on dense, vertically-aligned copper nanowires (CuNWs) embedded into polymer matrices. We evaluate the thermal and mechanical characteristics of 20-25% dense CuNW arrays with and without polydimethylsiloxane (PDMS) infiltration. The thermal resistance achieved is below 5 mm2 K W-1, over an order of magnitude lower than commercial heat sink compounds...
November 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29118756/th17-cell-and-epithelial-cell-crosstalk-during-inflammatory-bowel-disease-and-carcinogenesis
#12
REVIEW
Jan Kempski, Leonie Brockmann, Nicola Gagliani, Samuel Huber
The intestine is colonized by hundreds of different species of commensal bacteria, viruses, and fungi. Therefore, the intestinal immune system is constantly being challenged by foreign antigens. The immune system, the commensal microbiota, and the intestinal epithelial surface have to maintain a tight balance to guarantee defense against potential pathogens and to prevent chronic inflammatory conditions at the same time. Failure of these mechanisms can lead to a vicious cycle in which a perpetual tissue damage/repair process results in a pathological reorganization of the normal mucosal surface...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29116940/spin-flip-transitions-in-self-assembled-quantum-dots
#13
V N Stavrou
Detailed realistic calculations of the spin-flip time (T 1) for an electron in a self-assembled quantum dot (SAQD) due to emission of an acoustic phonon, using only bulk properties with no fitting parameters, are presented. Ellipsoidal lens shaped [Formula: see text] [Formula: see text]As quantum dots, with electronic states calculated using 8-band strain dependent [Formula: see text] theory, are considered. The phonons are treated as bulk acoustic phonons coupled to the electron by both deformation potential and piezoelectric interactions...
November 8, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29113565/using-learning-analytics-to-evaluate-a-video-based-lecture-series
#14
K H Vincent Lau, Pue Farooque, Gary Leydon, Michael L Schwartz, R Mark Sadler, Jeremy J Moeller
BACKGROUND: The video-based lecture (VBL), an important component of the flipped classroom (FC) and massive open online course (MOOC) approaches to medical education, has primarily been evaluated through direct learner feedback. Evaluation may be enhanced through learner analytics (LA) - analysis of quantitative audience usage data generated by video-sharing platforms. METHODS AND RESULTS: We applied LA to an experimental series of ten VBLs on electroencephalography (EEG) interpretation, uploaded to YouTube in the model of a publicly accessible MOOC...
November 7, 2017: Medical Teacher
https://www.readbyqxmd.com/read/29112369/on-the-better-understanding-of-the-surprisingly-high-performance-of-metal-organic-framework-based-mixed-matrix-membranes-using-the-example-of-uio-66-and-matrimid
#15
Sebastian Friebe, Alexander Mundstock, Kai Volgmann, Jürgen Caro
Metal-Organic Frameworks feature a certain framework flexibility, mainly due to a linker mobility inside the lattice. The latter is responsible for effects like breathing or gate-opening, thus making predictions of the sorption and diffusion behavior quite difficult. Permeation measurements on supported UiO-66 membranes at low temperatures and on polymer-coated UiO-66 membrane layers as well as 2H-NMR line shape studies and nitrogen sorption measurements of UiO-66 with deuterated linkers in Matrimid as Mixed-Matrix Membrane (MMM) indicate that the 2-site 180° flips (-flips) of the aromatic ring are hindered by the presence of (i) the surrounding polymer Matrimid and (ii) residual solvent molecules, thus giving profound insights in the molecular understanding of gas transport through Metal-Organic Framework based MMMs...
November 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29107869/surfactant-protein-d-regulates-caspase-8-mediated-cascade-of-the-intrinsic-pathway-of-apoptosis-while-promoting-bleb-formation
#16
Pascal Djiadeu, Nicole Farmakovski, Dhia Azzouz, Lakshmi P Kotra, Neil Sweezey, Nades Palaniyar
Surfactant-associated protein D (SP-D) is a soluble innate immune collectin present on many mucosal surfaces. We recently showed that SP-D suppresses the extrinsic pathway of apoptosis by downregulating caspase-8 activation. However, the effects of SP-D on the intrinsic pathway of apoptosis are not clearly understood. In the intrinsic pathway, cytochrome c is released by mitochondria into the cytoplasm. Oxidation of cytochrome c by cytochrome c oxidase activates the apoptosome and caspase-9 cascade. Both caspase-8- and caspase-9-mediated branches are activated in the intrinsic pathway of apoptosis; however, little is known about the relevance of the caspase-8 pathway in this context...
November 3, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29103482/quantitative-evaluation-of-knee-cartilage-and-meniscus-destruction-in-patients-with-rheumatoid-arthritis-using-t1%C3%AF-and-t2-mapping
#17
Xiang Hong Meng, Zhi Wang, Li Guo, Xiu Chan Liu, Yu Wei Zhang, Ze Wei Zhang, Xin Long Ma
OBJECTIVE: To calculate T1ρ and T2 values of articular cartilage and menisci in knee joints of patients with RA, and compare the values between RA patients and healthy volunteers, to gain insight into the pathogenesis of cartilage and meniscus degradation in patients with RA. MATERIALS AND METHODS: Nine patients with RA and knee joints symptoms were enrolled in the study, twenty healthy volunteers without knee joint diseases were included as controls. Sagittal fat-saturated T1ρ and T2 mapping images were obtained on a 3T MR scanner (GE750, GE Healthcare, Waukesha, WI), using a dedicated 8-channel knee coil...
November 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29100988/fast-b1-mapping-using-three-consecutive-rf-pulses-and-balanced-gradients-for-improved-bssfp-imaging
#18
Min-Oh Kim, Taehwa Hong, Dong-Hyun Kim
PURPOSE: To develop a B1(+) mapping during the transient phase of balanced steady state free precession (bSSFP) imaging which can be used for subsequent B1(+) inhomogeneity compensation. METHODS: Two images with different flip angles (FA) are acquired using single-shot spiral technique during the transient phase of bSSFP with three consecutive RF pulses and balanced gradients. Under the assumptions that the transmit (B1(+)) field varies slowly in spatial domain and T1 and T2 relaxation effects are negligible during 2·TR, B1(+) was estimated using the two magnitude images and bSSFP data was sequentially acquired...
October 31, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29100231/erratum-development-of-a-flipped-medical-school-dermatology-module-erratum
#19
None Available
No abstract text is available yet for this article.
November 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/29098750/the-relationship-between-esophageal-acid-exposure-and-the-esophageal-response-to-volumetric-distention
#20
D A Carlson, P Kathpalia, J Craft, M Tye, Z Lin, P J Kahrilas, J E Pandolfino
BACKGROUND: Increased esophagogastric junction (EGJ) distensibility is thought to contribute to gastroesophageal reflux disease (GERD). Using the functional lumen imaging probe (FLIP), we aimed to assess the esophageal response to distension among patients undergoing esophageal pH monitoring. METHODS: 25 patients (ages 22-73; 13 females) who underwent ambulatory wireless esophageal pH testing while off proton-pump inhibitors were evaluated with FLIP during sedated upper endoscopy...
November 2, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
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