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https://www.readbyqxmd.com/read/28935897/a-gateway-towards-non-collinear-spin-processing-using-three-atom-magnets-with-strong-substrate-coupling
#1
J Hermenau, J Ibañez-Azpiroz, Chr Hübner, A Sonntag, B Baxevanis, K T Ton, M Steinbrecher, A A Khajetoorians, M Dos Santos Dias, S Blügel, R Wiesendanger, S Lounis, J Wiebe
A cluster of a few magnetic atoms on the surface of a nonmagnetic substrate is one suitable realization of a bit for spin-based information technology. The prevalent approach to achieve magnetic stability is decoupling the cluster spin from substrate conduction electrons in order to suppress destabilizing spin-flips. However, this route entails less flexibility in tailoring the coupling between the bits needed for spin-processing. Here, we use a spin-resolved scanning tunneling microscope to write, read, and store spin information for hours in clusters of three atoms strongly coupled to a substrate featuring a cloud of non-collinearly polarized host atoms, a so-called non-collinear giant moment cluster...
September 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28926339/flipping-the-switch
#2
Xavier Pierrat, Alexandre Persat
A structural switch controls the architecture of Vibrio cholerae biofilms by mediating the interactions between two matrix components.
September 19, 2017: ELife
https://www.readbyqxmd.com/read/28926223/supramolecular-motors-on-graphite-surface-stabilized-by-charge-states-and-hydrogen-bonds
#3
Kai Sun, Ji-Yong Luo, Xin Zhang, Zhi-Jian Wu, Ying Wang, Hong-Kuan Yuan, Zu-Hong Xiong, Shao-Chun Li, Qi-Kun Xue, Jun-Zhong Wang
Molecular motors are nanoscale machines that convert external energies into controlled mechanical movements. In supramolecular motors, the rotator and stator are held together mechanically, and thus the rotation can be essentially barrier free when molecular conformation is negligible. However, nearly all the supramolecular motors appeared in solutions or host-guest complexes. Surface-mounted supramolecular motors have rarely been addressed, even though they are easily manipulated by external fields. Here we report a surface-mounted supramolecular motor assembled by charge states and hydrogen bonds...
September 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/28921660/rapid-whole-brain-gray-matter-imaging-using-single-slab-three-dimensional-dual-echo-fast-spin-echo-a-feasibility-study
#4
Hyunyeol Lee, Eung Yeop Kim, Chul-Ho Sohn, Jaeseok Park
PURPOSE: To achieve rapid, high resolution whole-brain gray matter (GM) imaging by developing a novel, single-slab three-dimensional dual-echo fast-spin-echo pulse sequence and GM-selective reconstruction. METHODS: Unlike conventional GM imaging that uses time-consuming double-inversion-recovery preparation, the proposed pulse sequence was designed to have two split portions along the echo train, in which the first half was dedicated to yield short inversion recovery (IR)-induced white matter suppression and variable-flip-angle-induced two-step GM signal evolution while the second half cerebrospinal fluid-only signals...
September 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28919831/flipped-classroom-model-for-learning-evidence-based-medicine
#5
Sydney Y Rucker, Zulfukar Ozdogan, Morhaf Al Achkar
Journal club (JC), as a pedagogical strategy, has long been used in graduate medical education (GME). As evidence-based medicine (EBM) becomes a mainstay in GME, traditional models of JC present a number of insufficiencies and call for novel models of instruction. A flipped classroom model appears to be an ideal strategy to meet the demands to connect evidence to practice while creating engaged, culturally competent, and technologically literate physicians. In this article, we describe a novel model of flipped classroom in JC...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/28918189/effects-of-temperature-and-peg-grafting-density-on-the-translocation-of-pegylated-nanoparticles-across-asymmetric-lipid-membrane
#6
Zuoheng Zhang, Xubo Lin, Ning Gu
Plasma membrane internalization of nanoparticles (NPs) is important for their biomedical applications such as drug-delivery carriers. On one hand, in order to improve their half-life in circulation, PEGylation has been widely used. However, it may hinder the NPs' membrane internalization ability. On the other hand, higher temperature could enhance the membrane permeability and may affect the NPs' ability to enter into or exit from cells. To make full use of their advantages, we systematically investigated the effects of temperature and PEG density on the translocation of PEGylated nanoparticles across the plasma asymmetric membrane of eukaryotic cells, using near-atom level coarse-grained molecular dynamics simulations...
September 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28916812/size-dependent-electrical-transport-properties-in-co-nanocluster-assembled-granular-films
#7
Q F Zhang, X Z Wang, L S Wang, H F Zheng, L Lin, J Xie, X Liu, Y L Qiu, Y Z Chen, D L Peng
A series of Co nanocluster-assembled films with cluster sizes ranging from 4.5 nm to 14.7 nm were prepared by the plasma-gas-condensation method. The size-dependent electrical transport properties were systematically investigated. Both of the longitudinal resistivity ([Formula: see text]) and saturated anomalous Hall resistivity ([Formula: see text]) continuously increased with the decrease of the cluster sizes (d). The [Formula: see text] firstly increased and then decreased with increasing the temperature for all samples, which could be well described by involving the thermally fluctuation-induced tunneling (FIT) process and scattering...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28915341/-31-p-magnetic-resonance-fingerprinting-for-rapid-quantification-of-creatine-kinase-reaction-rate-in-vivo
#8
Charlie Y Wang, Yuchi Liu, Shuying Huang, Mark A Griswold, Nicole Seiberlich, Xin Yu
The purpose of this work was to develop a (31) P spectroscopic magnetic resonance fingerprinting (MRF) method for fast quantification of the chemical exchange rate between phosphocreatine (PCr) and adenosine triphosphate (ATP) via creatine kinase (CK). A (31) P MRF sequence (CK-MRF) was developed to quantify the forward rate constant of ATP synthesis via CK ( kfCK), the T1 relaxation time of PCr ( T1PCr), and the PCr-to-ATP concentration ratio ( MRPCr). The CK-MRF sequence used a balanced steady-state free precession (bSSFP)-type excitation with ramped flip angles and a unique saturation scheme sensitive to the exchange between PCr and γATP...
September 15, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28913930/accuracy-repeatability-and-interplatform-reproducibility-of-t1-quantification-methods-used-for-dce-mri-results-from-a-multicenter-phantom-study
#9
Octavia Bane, Stefanie J Hectors, Mathilde Wagner, Lori L Arlinghaus, Madhava P Aryal, Yue Cao, Thomas L Chenevert, Fiona Fennessy, Wei Huang, Nola M Hylton, Jayashree Kalpathy-Cramer, Kathryn E Keenan, Dariya I Malyarenko, Robert V Mulkern, David C Newitt, Stephen E Russek, Karl F Stupic, Alina Tudorica, Lisa J Wilmes, Thomas E Yankeelov, Yi-Fei Yen, Michael A Boss, Bachir Taouli
PURPOSE: To determine the in vitro accuracy, test-retest repeatability, and interplatform reproducibility of T1 quantification protocols used for dynamic contrast-enhanced MRI at 1.5 and 3 T. METHODS: A T1 phantom with 14 samples was imaged at eight centers with a common inversion-recovery spin-echo (IR-SE) protocol and a variable flip angle (VFA) protocol using seven flip angles, as well as site-specific protocols (VFA with different flip angles, variable repetition time, proton density, and Look-Locker inversion recovery)...
September 14, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28913838/simultaneous-acquisition-of-perfusion-image-and-dynamic-mr-angiography-using-time-encoded-pseudo-continuous-asl
#10
Yuriko Suzuki, Michael Helle, Peter Koken, Marc Van Cauteren, Matthias J P van Osch
PURPOSE: Both dynamic magnetic resonance angiography (4D-MRA) and perfusion imaging can be acquired by using arterial spin labeling (ASL). While 4D-MRA highlights large vessel pathology, such as stenosis or collateral blood flow patterns, perfusion imaging provides information on the microvascular status. Therefore, a complete picture of the cerebral hemodynamic condition could be obtained by combining the two techniques. Here, we propose a novel technique for simultaneous acquisition of 4D-MRA and perfusion imaging using time-encoded pseudo-continuous arterial spin labeling...
September 14, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28912680/fyn-signaling-is-compartmentalized-to-dopamine-d1-receptor-expressing-neurons-in-the-dorsal-medial-striatum
#11
Khanhky Phamluong, Emmanuel Darcq, Su Wu, Samuel A Sakhai, Dorit Ron
The tyrosine kinase Fyn plays an important role in synaptic plasticity, learning, and memory. Here we report that Fyn is activated in response to 15 min D1 receptor (D1R) but not D2 receptor (D2R) stimulation specifically in the dorsomedial striatum (DMS) of mice but not in the other substriatal regions, the dorsolateral striatum (DLS), and the nucleus accumbens (NAc). Once activated Fyn phosphorylates its substrate GluN2B, and we show that GluN2B is phosphorylated only in the DMS but not in the other striatal regions...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28912348/a-time-to-divide-and-a-time-to-expand-histone-deacetylases-flip-a-gibberellin-oxidase-mediated-switch-in-root-meristem-cells
#12
Jennifer Mach
No abstract text is available yet for this article.
September 14, 2017: Plant Cell
https://www.readbyqxmd.com/read/28910107/perturbation-of-the-f19-l34-contact-in-amyloid-ss-1-40-fibrils-induces-only-local-structural-changes-but-abolishes-cytotoxicity
#13
Felix Hoffmann, Juliane Adler, Bappaditya Chandra, Kaustubh R Mote, Gül Bekcioglu-Neff, Daniel Sebastiani, Daniel Huster
We explored structural details of fibrils formed by a mutated amyloid β (Aβ(1-40) peptide carrying a Phe19 to Lys19 mutation, which was shown to completely abolish the toxicity of the molecule. Computer models suggest that the positively charged Lys19 side-chain is expelled from the hydrophobic fibril interior upon fibrillation. This can be accommodated by either a 180° flip of the entire lower β-strand (model M1) or local perturbations of the secondary structure in the direct vicinity of the mutated site (model M2)...
September 14, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28905516/simple-method-for-rf-pulse-measurement-using-gradient-reversal
#14
Vanessa L Landes, Krishna S Nayak
PURPOSE: To develop and evaluate a simple method for measuring the envelope of small-tip radiofrequency (RF) excitation waveforms in MRI, without extra hardware or synchronization. THEORY AND METHODS: Gradient reversal approach to evaluate RF (GRATER) involves RF excitation with a constant gradient and reversal of that gradient during signal reception to acquire the time-reversed version of an RF envelope. An outer-volume suppression prepulse is used optionally to preselect a uniform volume...
September 14, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28905416/sar-and-scan-time-optimized-3d-whole-brain-double-inversion-recovery-imaging-at-7t
#15
Eberhard D Pracht, Thorsten Feiweier, Philipp Ehses, Daniel Brenner, Alard Roebroeck, Bernd Weber, Tony Stöcker
PURPOSE: The aim of this project was to implement an ultra-high field (UHF) optimized double inversion recovery (DIR) sequence for gray matter (GM) imaging, enabling whole brain coverage in short acquisition times ( ≈5 min, image resolution 1 mm(3) ). METHODS: A 3D variable flip angle DIR turbo spin echo (TSE) sequence was optimized for UHF application. We implemented an improved, fast, and specific absorption rate (SAR) efficient TSE imaging module, utilizing improved reordering...
September 14, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28904817/ihc-based-subcellular-quantification-provides-new-insights-into-prognostic-relevance-of-flip-and-procaspase-8-in-non-small-cell-lung-cancer
#16
Ryan A Hutchinson, Helen G Coleman, Kathy Gately, Vincent Young, Siobhan Nicholson, Robert Cummins, Elaine Kay, Sean O Hynes, Philip D Dunne, Seedevi Senevirathne, Peter W Hamilton, Darragh G McArt, Daniel B Longley
In this study, we developed an image analysis algorithm for quantification of two potential apoptotic biomarkers in non-small-cell lung cancer (NSCLC): FLIP and procaspase-8. Immunohistochemical expression of FLIP and procaspase-8 in 184 NSCLC tumors were assessed. Individual patient cores were segmented and classified as tumor and stroma using the Definiens Tissue Studio. Subsequently, chromogenic expression of each biomarker was measured separately in the nucleus and cytoplasm and reported as a quantitative histological score...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28903672/cognitive-and-interpersonal-features-of-intellectual-humility
#17
Mark R Leary, Kate J Diebels, Erin K Davisson, Katrina P Jongman-Sereno, Jennifer C Isherwood, Kaitlin T Raimi, Samantha A Deffler, Rick H Hoyle
Four studies examined intellectual humility-the degree to which people recognize that their beliefs might be wrong. Using a new Intellectual Humility (IH) Scale, Study 1 showed that intellectual humility was associated with variables related to openness, curiosity, tolerance of ambiguity, and low dogmatism. Study 2 revealed that participants high in intellectual humility were less certain that their beliefs about religion were correct and judged people less on the basis of their religious opinions. In Study 3, participants high in intellectual humility were less inclined to think that politicians who changed their attitudes were "flip-flopping," and Study 4 showed that people high in intellectual humility were more attuned to the strength of persuasive arguments than those who were low...
June 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28898696/a-dual-role-of-caspase-8-in-triggering-and-sensing-proliferation-associated-dna-damage-a-key-determinant-of-liver-cancer-development
#18
Yannick Boege, Mohsen Malehmir, Marc E Healy, Kira Bettermann, Anna Lorentzen, Mihael Vucur, Akshay K Ahuja, Friederike Böhm, Joachim C Mertens, Yutaka Shimizu, Lukas Frick, Caroline Remouchamps, Karun Mutreja, Thilo Kähne, Devakumar Sundaravinayagam, Monika J Wolf, Hubert Rehrauer, Christiane Koppe, Tobias Speicher, Susagna Padrissa-Altés, Renaud Maire, Jörn M Schattenberg, Ju-Seong Jeong, Lei Liu, Stefan Zwirner, Regina Boger, Norbert Hüser, Roger J Davis, Beat Müllhaupt, Holger Moch, Henning Schulze-Bergkamen, Pierre-Alain Clavien, Sabine Werner, Lubor Borsig, Sanjiv A Luther, Philipp J Jost, Ricardo Weinlich, Kristian Unger, Axel Behrens, Laura Hillert, Christopher Dillon, Michela Di Virgilio, David Wallach, Emmanuel Dejardin, Lars Zender, Michael Naumann, Henning Walczak, Douglas R Green, Massimo Lopes, Inna Lavrik, Tom Luedde, Mathias Heikenwalder, Achim Weber
Concomitant hepatocyte apoptosis and regeneration is a hallmark of chronic liver diseases (CLDs) predisposing to hepatocellular carcinoma (HCC). Here, we mechanistically link caspase-8-dependent apoptosis to HCC development via proliferation- and replication-associated DNA damage. Proliferation-associated replication stress, DNA damage, and genetic instability are detectable in CLDs before any neoplastic changes occur. Accumulated levels of hepatocyte apoptosis determine and predict subsequent hepatocarcinogenesis...
September 11, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28895045/influence-of-gd-eob-dtpa-on-proton-density-fat-fraction-using-the-six-echo-dixon-method-in-3-tesla-magnetic-resonance-imaging
#19
Tatsuya Hayashi, Kei Fukuzawa, Hiroshi Kondo, Hiroshi Onodera, Shuji Toyotaka, Rie Tojo, Shimpei Yano, Masakatsu Tano, Tosiaki Miyati, Jun'ichi Kotoku, Takahide Okamoto, Keiko Toyoda, Hiroshi Oba
The purpose of this study was to evaluate whether disodium gadoxetate (Gd-EOB-DTPA) affects proton density fat fractions (PDFFs) during use of the multiecho Dixon (meDixon) method in phantom and simulation magnetic resonance imaging (MRI) studies at 3 T. Fat-water phantoms comprising vegetable fat-water emulsions with varying fat volume percentages (0, 5, 10, 15, 20, 30, 40, and 50) and Gd-EOB-DTPA concentrations (0 and 0.4 mM) were prepared. Phantoms without Gd-EOB-DTPA were defined as precontrast, and those with Gd-EOB-DTPA were defined as postcontrast...
September 11, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/28894177/a-viral-protein-antibiotic-inhibits-lipid-ii-flippase-activity
#20
Karthik R Chamakura, Lok-To Sham, Rebecca M Davis, Lorna Min, Hongbaek Cho, Natividad Ruiz, Thomas G Bernhardt, Ry Young
For bacteriophage infections, the cell walls of bacteria, consisting of a single highly polymeric molecule of peptidoglycan (PG), pose a major problem for the release of progeny virions. Phage lysis proteins that overcome this barrier can point the way to new antibacterial strategies (1) , especially small lytic single-stranded DNA (the microviruses) and RNA phages (the leviviruses) that effect host lysis using a single non-enzymatic protein (2) . Previously, the A2 protein of levivirus Qβ and the E protein of the microvirus ϕX174 were shown to be 'protein antibiotics' that inhibit the MurA and MraY steps of the PG synthesis pathway (2-4) ...
September 11, 2017: Nature Microbiology
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