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https://www.readbyqxmd.com/read/29792865/aspirin-restores-abt-737-mediated-apoptosis-in-human-renal-carcinoma-cells
#1
Yen-Chuan Ou, Jian-Ri Li, Jiaan-Der Wang, Wen-Ying Chen, Yu-Hsiang Kuan, Ching-Ping Yang, Su-Lan Liao, Hsi-Chi Lu, Chun-Jung Chen
Aspirin is a novel chemopreventive agent against malignancy. However, outcomes of aspirin monotherapy of renal cell carcinoma (RCC) are inconsistent across studies. ABT-737, an BH3 mimetic inhibitor, is also a promising antitumor drug. Cancer cells including those from RCC, that have high levels of Mcl-1, are refractory to ABT-737-induced apoptosis. We here investigated how aspirin treatment modulates the ABT-737-induced apoptosis. Using the in vitro model of human 786-O cells, we showed that aspirin had sensitized cells to ABT-737 induced apoptosis...
May 21, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29792707/nano-scale-conductive-filament-with-alternating-rectification-as-an-artificial-synapse-building-block
#2
Dan Berco, Yu Zhou, Sankara Rao Gollu, Pranav Sairam Kalaga, Abhisek Kole, Mohamed Hassan, Diing Shenp Ang
A popular approach for resistive memory (RRAM) based hardware implementation of neural networks utilizes one (or two) device that functions as an analog synapse in a crossbar structure of perpendicular pre- and post-synaptic neurons. An ideal fully automated, large scale artificial neural network, that matches a biologic counterpart (in terms of density and energy consumption), thus requires nano sized, extremely low power devices with a wide dynamic range and multi level functionality. Unfortunately the tradeoff between these traits proves to be a serious obstacle in the realization of brain inspired computing platforms yet to be overcome...
May 24, 2018: ACS Nano
https://www.readbyqxmd.com/read/29792041/increased-diagnostic-confidence-in-the-diagnosis-of-pituitary-micro-lesions-with-the-addition-of-three-dimensional-sampling-perfection-with-application-optimized-contrasts-using-different-flip-angle-evolutions-sequences
#3
Ying Tang, Yue Wu, Hua Zhang, Jing Wang, ZhenWei Yao
Background Conventional magnetic resonance imaging (MRI) is adversely affected by thick slices, small intersection gaps, and the partial volume effect, leading to the missed diagnosis or misdiagnosis of pituitary micro-lesions. Purpose To evaluate the diagnostic yield of three-dimensional sampling perfection with application-optimized contrasts using different flip-angle evolutions (3D-T2 SPACE) sequences compared with a standard MRI protocol for the diagnosis of pituitary micro-lesions. Material and Methods The MRI findings of 664 patients with clinically suspected pituitary lesions were retrospectively analyzed...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29789479/anandamide-revisited-how-cholesterol-and-ceramides-control-receptor-dependent-and-receptor-independent-signal-transmission-pathways-of-a-lipid-neurotransmitter
#4
REVIEW
Coralie Di Scala, Jacques Fantini, Nouara Yahi, Francisco J Barrantes, Henri Chahinian
Anandamide is a lipid neurotransmitter derived from arachidonic acid, a polyunsaturated fatty acid. The chemical differences between anandamide and arachidonic acid result in a slightly enhanced solubility in water and absence of an ionisable group for the neurotransmitter compared with the fatty acid. In this review, we first analyze the conformational flexibility of anandamide in aqueous and membrane phases. We next study the interaction of the neurotransmitter with membrane lipids and discuss the molecular basis of the unexpected selectivity of anandamide for cholesterol and ceramide from among other membrane lipids...
May 22, 2018: Biomolecules
https://www.readbyqxmd.com/read/29787500/evaluation-of-the-communication-between-arachnoid-cysts-and-neighboring-cerebrospinal-fluid-spaces-by-t2w-3d-space-with-variant-flip-angle-technique-at-3-t
#5
Oktay Algin
PURPOSE: Phase-contrast cine magnetic resonance imaging (PC-MRI) is a widely used technique for determination of possible communication of arachnoid cysts (ACs). Three-dimensional (3D) sampling perfection with application-optimized contrasts using different flip-angle evolutions (3D-SPACE) technique is a relatively new method for 3D isotropic scanning of the entire cranium within a short time. In this research, the usage of the 3D-SPACE technique in differentiation of communicating or noncommunicating type ACs was evaluated...
May 21, 2018: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29785150/-flipped-classroom-for-academic-and-career-advising-an-innovative-technique-for-medical-student-advising
#6
Richard Amini, Brady S Laughlin, Kathy W Smith, Violet P Siwik, William J Adamas-Rappaport, George T Fantry
Introduction: Career advising for medical students can be challenging for both the student and the adviser. Our objective was to design, implement, and evaluate a "flipped classroom" style advising session. Methods: We performed a single-center cross-sectional study at an academic medical center, where a novel flipped classroom style student advising model was implemented and evaluated. In this model, students were provided a document to review and fill out prior to their one-on-one advising session...
2018: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/29781463/hepatic-arterial-infusion-pump-complications-and-nursing-management-regarding-use-in-patients-with-colorectal-cancer
#7
Deborah Italiano
BACKGROUND: The hepatic arterial infusion (HAI) pump is a treatment-delivery method based on the principle of targeting the tumor site directly and can be used alone or in combination with systemic chemotherapy. OBJECTIVES: The intent of this article is to serve as a resource for oncology nurses to safely identify and manage HAI pump complications. These complications include seroma, flipped HAI pump, infection, changes in pressure and temperature, challenging access, dry pump, high residual volume, chemical hepatitis, risk of ulcer, and radiologic imaging considerations...
June 1, 2018: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29779382/specific-stereoisomeric-conformations-determine-the-drug-potency-of-cladosporin-scaffold-against-malarial-parasite
#8
Pronay Das, Palak Babbar, Nipun Malhotra, Manmohan Sharma, Gorakhnath R Jachak, Rajesh G Gonnade, Dhanasekaran Shanmugam, Karl Harlos, Manickam Yogavel, Amit Sharma, D Srinivasa Reddy
The dependence of drug potency on diastereomeric configurations is a key facet. Using a novel general divergent synthetic route for a three-chiral centre anti-malarial natural product cladosporin, we built its complete library of stereoisomers (cladologs) and assessed their inhibitory potential using parasite-, enzyme- and structure-based assays. We show that potency is manifest via tetrahyropyran ring conformations that are housed in the ribose binding pocket of parasite lysyl tRNA synthetase (KRS). Strikingly, drug potency between top and worst enantiomers varied 500-fold, and structures of KRS-cladolog complexes reveal that alterations at C3 and C10 are detrimental to drug potency where changes at C3 are sensed by rotameric flipping of Glutamate332...
May 21, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29777820/accuracy-and-precision-of-quantitative-dce-mri-parameters-how-should-one-estimate-contrast-concentration
#9
Nicole Wake, Hersh Chandarana, Henry Rusinek, Koji Fujimoto, Linda Moy, Daniel K Sodickson, Sungheon Gene Kim
INTRODUCTION: Pharmacokinetic parameters derived from dynamic contrast-enhanced MRI (DCE-MRI) data are sensitive to acquisition and post-processing techniques, which makes it difficult to compare results obtained using different methods. In particular, one of the most important factors affecting estimation of model parameters is how to convert MRI signal intensities to contrast agent concentration. The purpose of our study was to quantitatively compare a linear signal-to-concentration conversion (LC) as an approximation and a non-linear conversion (NLC) based on the MRI signal equation, in terms of the accuracy and precision of the pharmacokinetic parameters in T1 -weighted DCE-MRI...
May 16, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29775352/three-dimensional-color-code-thresholds-via-statistical-mechanical-mapping
#10
Aleksander Kubica, Michael E Beverland, Fernando Brandão, John Preskill, Krysta M Svore
Three-dimensional (3D) color codes have advantages for fault-tolerant quantum computing, such as protected quantum gates with relatively low overhead and robustness against imperfect measurement of error syndromes. Here we investigate the storage threshold error rates for bit-flip and phase-flip noise in the 3D color code (3DCC) on the body-centered cubic lattice, assuming perfect syndrome measurements. In particular, by exploiting a connection between error correction and statistical mechanics, we estimate the threshold for 1D stringlike and 2D sheetlike logical operators to be p_{3DCC}^{(1)}≃1...
May 4, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29772677/lambertianic-acid-sensitizes-non-small-cell-lung-cancers-to-trail-induced-apoptosis-via-inhibition-of-xiap-nf-%C3%AE%C2%BAb-and-activation-of-caspases-and-death-receptor-4
#11
Deok Soo Ahn, Hyo Jung Lee, Jisung Hwang, Hyukgyu Han, Bonglee Kim, BumSang Shim, Sung-Hoon Kim
Lambertianic acid (LA) is a biologically active compound from the leaves of Pinus koraiensis. In the present study, apoptotic mechanisms of LA plus TNF-related apoptosis-inducing ligand (TRAIL) were elucidated in non-small cell lung cancer cells (NSCLCs). Cytotoxicity assay, flow cytometry, immunoprecipitation, and Western blotting were performed. Here, combined treatment of LA and TRAIL increased cytotoxicity, sub-G1 population, cleaved poly (ADP-ribose) polymerase (PARP), and caspase3/8/9 in A549 and H1299 cells compared to LA or TRAIL alone...
May 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29770422/biodegradable-toughened-nanohybrid-shape-memory-polymer-for-smart-biomedical-applications
#12
Arpan Biswas, Akhand Pratap Singh, Dipak Rana, Vinod K Aswal, Pralay Maiti
A polyurethane nanohybrid has been prepared through the in situ polymerization of an aliphatic diisocyanate, ester polyol and a chain extender in the presence of two-dimensional platelets. Polymerization within the platelet galleries helps to intercalate, generate diverse nanostructure and improve the nano to macro scale self-assembly, which leads to a significant enhancement in the toughness and thermal stability of the nanohybrid in comparison to pure polyurethane. The extensive interactions, the reason for property enhancement, between nanoplatelets and polymer chains are revealed through spectroscopic measurements and thermal studies...
May 17, 2018: Nanoscale
https://www.readbyqxmd.com/read/29769051/knee-dgemric-at-7-t-comparison-against-1-5-t-and-evaluation-of-t-1-mapping-methods
#13
Pernilla Peterson, Carl Johan Tiderius, Emma Olsson, Björn Lundin, Lars E Olsson, Jonas Svensson
BACKGROUND: dGEMRIC (delayed Gadolinium Enhanced Magnetic Resonance Image of Cartilage) is a well-established technique for cartilage quality assessment in osteoarthritis at clinical field strengths. The method is robust, but requires injection of contrast agent and a cumbersome examination procedure. New non-contrast-agent-based techniques for cartilage quality assessment are currently being developed at 7 T. However, dGEMRIC remains an important reference technique during this development...
May 16, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29766176/modelling-absorption-and-emission-of-a-meso-aniline-bodipy-based-dye-with-molecular-mechanics
#14
Flip de Jong, Milica Feldt, Jonas Feldt, Jeremy N Harvey
Absorption and emission spectra of 8-(4-dimethylaminophenyl)-1,3,5,7-tetramethyl-BODIPY have been calculated using Coupled Cluster (CC) approaches, Time-Dependent Density Functional Theory (TD-DFT) and a QM-informed MM approach. In the case of TD-DFT calculations solvent effects were included using the linear-response (LR), corrected linear response (cLR) and state specific (SS) Polarizable Continuum Model (PCM). We show that range-separated functionals give results in reasonable agreement with coupled cluster methods but both tend to overestimate excitation energies...
May 16, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29765713/different-packing-motifs-of-isomeric-e-n-halo-phenyl-methyl-idene-n-methyl-2-thio-phen-2-yl-acetohydrazides-controlled-by-c-h%C3%A2-o-inter-actions
#15
Laura N F Cardoso, Thais C M Noguiera, James L Wardell, Marcus V N de Souza, William T A Harrison
The crystal structures of three isomeric ( E )- N '-(chloro-phenyl-methyl-idene)- N -methyl-2-(thio-phen-2-yl)acetohydrazides (C14 H13 ClN2 OS) are described, with the Cl atom in ortho (I), meta (III) and para (IV) positions in the benzene ring. The ortho -bromo derivative (II) (C14 H13 BrN2 OS), which is isostructural with its chloro congener (I), is also reported. Mol-ecules (I)-(III) have similar conformations, which approximate to l-shapes, as indicated by their N-C-C-Ct (t = thio-phene) torsion angles of -90...
March 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29765043/programmable-sequential-mutagenesis-by-inducible-cpf1-crrna-array-inversion
#16
Ryan D Chow, Hyunu Ray Kim, Sidi Chen
Mutations and genetic alterations are often sequentially acquired in various biological and pathological processes, such as development, evolution, and cancer. Certain phenotypes only manifest with precise temporal sequences of genetic events. While multiple approaches have been developed to model the effects of mutations in tumorigenesis, few recapitulate the stepwise nature of cancer evolution. Here we describe a flexible sequential mutagenesis system, Cpf1-Flip, with inducible inversion of a single crRNA array (FlipArray), and demonstrate its application in stepwise mutagenesis in murine and human cells...
May 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29764690/inter-ray-variation-in-metatarsal-strength-properties-in-humans-and-african-apes-implications-for-inferring-bipedal-biomechanics-in-the-olduvai-hominid-8-foot
#17
Biren A Patel, Tea Jashashvili, Stephanie H Bui, Kristian J Carlson, Nicole L Griffin, Ian J Wallace, Caley M Orr, Randall L Susman
When measured as a ratio of mean midshaft diameter to bone length, the OH 8 fossil hominin foot exhibits a metatarsal (Mt) robusticity pattern of 1 > 5 > 3 > 4 > 2, which differs from the widely perceived "common" modern human pattern (1 > 5 > 4 > 3 > 2); African apes generally exhibit a third pattern (1 > 2 > 3 > 4 > 5). Largely because of the relative ranking of Mt2 and Mt5, OH 8 metatarsals structurally resemble the pattern exhibited by bipedal humans more than the pattern of quadrupedal and climbing African apes...
May 12, 2018: Journal of Human Evolution
https://www.readbyqxmd.com/read/29764135/fast-forward-langevin-dynamics-with-momentum-flips
#18
Mahdi Hijazi, David M Wilkins, Michele Ceriotti
Stochastic thermostats based on the Langevin equation, in which a system is coupled to an external heat bath, are popular methods for temperature control in molecular dynamics simulations due to their ergodicity and their ease of implementation. Traditionally, these thermostats suffer from sluggish behavior in the limit of high friction, unlike thermostats of the Nosé-Hoover family whose performance degrades more gently in the strong coupling regime. We propose a simple and easy-to-implement modification to the integration scheme of the Langevin algorithm that addresses the fundamental source of the overdamped behavior of high-friction Langevin dynamics: if the action of the thermostat causes the momentum of a particle to change direction, it is flipped back...
May 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29763672/using-3d-spatial-correlations-to-improve-the-noise-robustness-of-multi-component-analysis-of-3d-multi-echo-quantitative-t2-relaxometry-data
#19
Dushyant Kumar, Hari Hariharan, Tobias D Faizy, Patrick Borchert, Susanne Siemonsen, Jens Fiehler, Ravinder Reddy, Jan Sedlacik
PURPOSE: We present a computationally feasible and iterative multi-voxel spatially regularized algorithm for myelin water fraction (MWF) reconstruction. This method utilizes 3D spatial correlations present in anatomical/pathological tissues and underlying B1+ -inhomogeneity or flip angle inhomogeneity to enhance the noise robustness of the reconstruction while intrinsically accounting for stimulated echo contributions using T2-distribution data alone. METHODS: Simulated data and in vivo data acquired using 3D non-selective multi-echo spin echo (3DNS-MESE) were used to compare the reconstruction quality of the proposed approach against those of the popular algorithm (the method by Prasloski et al...
May 12, 2018: NeuroImage
https://www.readbyqxmd.com/read/29763318/on-the-peculiar-molecular-shape-and-size-dependence-of-the-dynamics-of-fluids-confined-in-a-small-pore-metal-organic-framework
#20
Ioannis Skarmoutsos, Mohamed Eddaoudi, Guillaume Maurin
Force field based-Molecular dynamics simulations were deployed to systematically explore the dynamics of confined molecules of different shapes and sizes, i.e. linear (CO2 and N2) and spherical (CH4) fluids, in a model small pore system, i.e. the Metal-Organic Framework SIFSIX-2-Cu-i. These computations unveil an unprecedented molecular symmetry dependence of the translational and rotational dynamics of fluids confined in channel-like nanoporous materials. In particular this peculiar behaviour is reflected by the extremely slow decay of the Legendre reorientational correlation functions of even-parity order for the linear fluids which is associated to jump-like orientation flips, while the spherical fluid shows a very fast decay taking place in a sub-picosecond time scale...
May 15, 2018: Journal of Physical Chemistry Letters
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