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https://www.readbyqxmd.com/read/28820757/flipping-the-nursing-classroom-without-flipping-out-the-students
#1
Victoria Anne Greenwood, Caroline Mosca
Flipping the class has been touted as a method of increasing student participation and improving learning outcomes. In this study, nursing students were introduced to the flipped classroom. They were instructed to listen to narrated PowerPoint presentations before class and be ready to participate in case studies that would enhance their understanding of important concepts. When comparing student test scores before and after flipping the classroom, we found a statistically significant increase of 8.04 points after the change in instruction...
August 17, 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/28811581/the-key-energy-scales-of-gd-based-metallofullerene-determined-by-resonant-inelastic-x-ray-scattering-spectroscopy
#2
Yu-Cheng Shao, L Andrew Wray, Shih-Wen Huang, Yi-Sheng Liu, Wang Song, Shangfeng Yang, Yi-De Chuang, Jinghua Guo, Way-Faung Pong
Endohedral metallofullerenes, formed by encaging Gd inside fullerenes like C80, can exhibit enhanced proton relaxitivities compared with other Gd-chelates, making them the promising contrast agents for magnetic resonance imaging (MRI). However, the underlying key energy scales of Gd x Sc3-x N@C80 (x  =  1-3) remain unclear. Here, we carry out resonant inelastic x-ray scattering (RIXS) experiments on Gd x Sc3-x N@C80 at Gd N 4,5-edges to directly study the electronic structure and spin flip excitations of Gd 4f electrons...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811516/q-factor-enhancement-of-fano-resonance-in-all-dielectric-metasurfaces-by-modulating-meta-atom-interactions
#3
Guanghou Sun, Lierong Yuan, Yi Zhang, Xuejin Zhang, Yongyuan Zhu
We numerically investigated the effects of meta-atom interactions on the Fano resonance in all-dielectric metasurfaces by introducing alternately flipped asymmetric paired bars (APBs) and split asymmetric paired bars (SAPBs). With alternately flipped configurations, the Q-factor of the Fano resonance is significantly enhanced up to one order of magnitude, and the electric field is strengthened by more than twice. Abnormally, the Q-factor increases with gap size in the alternately flipped SAPBs. These are attributed to the destructive interaction among nearest-neighbor dipole resonators...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808321/the-proteasome-deubiquitinase-inhibitor-b-ap15-enhances-dr5-activation-induced-apoptosis-through-stabilizing-dr5
#4
You-Take Oh, Liang Deng, Jiusheng Deng, Shi-Yong Sun
b-AP15 and its derivatives block proteasome deubiquitinase (DUB) activity and have been developed and tested in the clinic as potential cancer therapeutic agents. b-AP15 induces apoptosis in cancer cells, but the underlying mechanisms are largely undefined. The current study focuses on studying the modulatory effects of b-AP15 on death receptor 5 (DR5) levels and DR5 activation-induced apoptosis as well as on understanding the underlying mechanisms. Treatment with b-AP15 potently increased DR5 levels including cell surface DR5 in different cancer cell lines with limited or no effects on the levels of other related proteins including DR4, c-FLIP, FADD, and caspase-8...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28806703/nox4-mediated-ros-production-induces-apoptotic-cell-death-via-down-regulation-of-c-flip-and-mcl-1-expression-in-combined-treatment-with-thioridazine-and-curcumin
#5
Seung Un Seo, Tae Hwan Kim, Dong Eun Kim, Kyoung-Jin Min, Taeg Kyu Kwon
Thioridazine is known to have anti-tumor effects by inhibiting PI3K/Akt signaling, which is an important signaling pathway in cell survival. However, thioridazine alone does not induce apoptosis in head and neck squamous cell carcinoma (AMC-HN4), human breast carcinoma (MDA-MB231), and human glioma (U87MG) cells. Therefore, we investigated whether combined treatment with thioridazine and curcumin induces apoptosis. Combined treatment with thioridazine and curcumin markedly induced apoptosis in cancer cells without inducing apoptosis in human normal mesangial cells and human normal umbilical vein cells (EA...
August 9, 2017: Redox Biology
https://www.readbyqxmd.com/read/28800131/atg2a-b-deficiency-switches-cytoprotective-autophagy-to-non-canonical-caspase-8-activation-and-apoptosis
#6
Zhenyuan Tang, Yoshinori Takahashi, Chong Chen, Ying Liu, Haiyan He, Nikolaos Tsotakos, Jacob M Serfass, Melat T Gebru, Han Chen, Megan M Young, Hong-Gang Wang
Autophagosomal membranes are emerging as platforms for various cell survival and death signaling networks beyond autophagy. While autophagy-dependent cell death has been reported in response to a variety of stimuli, the underlying molecular mechanisms remain far from clear. Here, we demonstrate that inhibition of autophagosome completion by Atg2A/B deletion accumulates immature autophagosomal membranes that promote non-canonical caspase-8 activation in response to nutrient starvation via an intracellular death-inducing signaling complex (iDISC)...
August 11, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28799669/choosing-the-appropriate-shangring-size-for-paediatric-circumcision-using-the-no-flip-technique
#7
Li Fang, Weichao Zhu, Zhongfei Xie, Kerong Wu, Guoyao Wang, Zejun Yan, Zhong Zheng, Qi Ma, Yue Cheng
AIM: To determine the correct ShangRing size for paediatric circumcision using the no-flip technique. METHODS: A cohort of 104 boys (from 6 to 14 years) underwent ShangRing circumcision at Ningbo First Hospital, China. The patients were randomly divided into three groups according to the different methods used for choosing the ring size. For Group A, the ring size was chosen using the ShangRing measuring tape; for Group B, ring size was chosen based on the diameter of penis measured using a self-designed scale plate; and for Group C, ring size was chosen based on the diameter of the glans measured using the self-designed scale plate...
August 11, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28799210/whole-brain-arteriography-and-venography-using-improved-velocity-selective-saturation-pulse-trains
#8
Wenbo Li, Feng Xu, Michael Schär, Jing Liu, Taehoon Shin, Yansong Zhao, Peter C M van Zijl, Bruce A Wasserman, Ye Qiao, Qin Qin
PURPOSE: To develop velocity-selective (VS) MR angiography (MRA) protocols for arteriography and venography with whole-brain coverage. METHODS: Tissue suppression using velocity-selective saturation (VSS) pulse trains is sensitive to radiofrequency field (B1 +) inhomogeneity. To reduce its sensitivity, we replaced the low-flip-angle hard pulses in the VSS pulse train with optimal composite (OCP) pulses. Additionally, new pulse sequences for arteriography and venography were developed by placing spatially selective inversion pulses with a delay to null signals from either venous or arterial blood...
August 10, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28797739/mb-swift-functional-mri-during-deep-brain-stimulation-in-rats
#9
Lauri J Lehto, Djaudat Idiyatullin, Jinjin Zhang, Lynn Utecht, Gregor Adriany, Michael Garwood, Olli Gröhn, Shalom Michaeli, Silvia Mangia
Recently introduced 3D radial MRI pulse sequence entitled Multi-Band SWeep Imaging with Fourier Transformation (MB-SWIFT) having inherently zero acquisition delay was used to obtain functional MRI (fMRI) contrast in rat's brain at 9.4 Tesla during deep brain stimulation (DBS). The results demonstrate that MB-SWIFT allows images free of susceptibility artefacts, and provides an excellent fMRI activation contrast in the brain. Flip angle dependence of the MB-SWIFT fMRI signal and elimination of the fMRI contrast while using saturation bands, indicate a blood flow origin of the observed fMRI contrast...
August 7, 2017: NeuroImage
https://www.readbyqxmd.com/read/28796308/technical-note-the-effect-of-2d-excitation-profile-on-t1-measurement-accuracy-using-the-variable-flip-angle-method-with-an-average-flip-angle-assumption
#10
Bryant T Svedin, Dennis L Parker
PURPOSE: To study the accuracy and precision of T1 estimates using the Variable Flip Angle (VFA) method in 2D and 3D acquisitions. METHODS: Excitation profiles were simulated using numerical implementation of the Bloch equations for Hamming-windowed sinc excitation pulses with different time-bandwidth products (TBP) of 2, 6, and 10 and for T1 values of 295 ms and 1045 ms. Experimental data was collected in 5° increments from 5° to 90° for the same T1 and TBP values...
August 10, 2017: Medical Physics
https://www.readbyqxmd.com/read/28795159/spin-flip-statistics-and-spin-wave-interference-patterns-in-ising-ferromagnetic-films-a-monte-carlo-study
#11
Muktish Acharyya
The spin wave interference is studied in two dimensional Ising ferromagnet driven by two coherent spherical magnetic field waves by Monte Carlo simulation. The spin waves are found to propagate and interfere according to the classic rule of interference pattern generated by two point sources. The interference pattern of spin wave is observed in one boundary of the lattice. The interference pattern is detected and studied by spin flip statistics at high and low temperatures. The destructive interference is manifested as the large number of spin flips and vice versa...
July 2017: Heliyon
https://www.readbyqxmd.com/read/28793989/early-enteral-tube-feeding-in-optimizing-treatment-of-hyperemesis-gravidarum-the-maternal-and-offspring-outcomes-after-treatment-of-hyperemesis-by-refeeding-mother-randomized-controlled-trial
#12
Iris J Grooten, Marjette H Koot, Joris Am van der Post, Joke Mj Bais, Carrie Ris-Stalpers, Christiana Naaktgeboren, Henk A Bremer, David P van der Ham, Wieteke M Heidema, Anjoke Huisjes, Gunilla Kleiverda, Simone Kuppens, Judith Oeh van Laar, Josje Langenveld, Flip van der Made, Mariëlle G van Pampus, Dimitri Papatsonis, Marie-José Pelinck, Paula J Pernet, Leonie van Rheenen, Robbert J Rijnders, Hubertina Cj Scheepers, Tatjana E Vogelvang, Ben W Mol, Tessa J Roseboom, Rebecca C Painter
Background: Hyperemesis gravidarum (HG) leads to dehydration, poor nutritional intake, and weight loss. HG has been associated with adverse pregnancy outcomes such as low birth weight. Information about the potential effectiveness of treatments for HG is limited.Objective: We hypothesized that in women with HG, early enteral tube feeding in addition to standard care improves birth weight.Design: We performed a multicenter, open-label randomized controlled trial [Maternal and Offspring outcomes after Treatment of HyperEmesis by Refeeding (MOTHER)] in 19 hospitals in the Netherlands...
August 9, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28790966/randomized-controlled-study-of-a-remote-flipped-classroom-neuro-otology-curriculum
#13
Frederick Robert Carrick, Mahera Abdulrahman, Ahmed Hankir, Maksim Zayaruzny, Kinda Najem, Palita Lungchukiet, Roger A Edwards
CONTEXT: Medical Education can be delivered in the traditional classroom or via novel technology including an online classroom. OBJECTIVE: To test the hypothesis that learning in an online classroom would result in similar outcomes as learning in the traditional classroom when using a flipped classroom pedagogy. DESIGN: Randomized controlled trial. A total of 274 subjects enrolled in a Neuro-otology training program for non-Neuro-otologists of 25 h held over a 3-day period...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28790121/cardiovascular-magnetic-resonance-relaxometry-predicts-regional-functional-outcome-after-experimental-myocardial-infarction
#14
Sebastian M Haberkorn, Christoph Jacoby, Zhaoping Ding, Petra Keul, Florian Bönner, Amin Polzin, Bodo Levkau, Jürgen Schrader, Malte Kelm, Ulrich Flögel
BACKGROUND: Cardiovascular magnetic resonance with gadolinium-based contrast agents has established as gold standard for tissue characterization after myocardial infarction (MI). Beyond accurate diagnosis, the value of cardiovascular magnetic resonance to predict the outcome after MI has yet to be substantiated. METHODS AND RESULTS: Recent cardiovascular magnetic resonance approaches were systematically compared for quantification of tissue injury and functional impairment after MI using murine models with permanent left anterior descending coronary artery ligation (n=14) or 50 minutes ischemia/reperfusion (n=13)...
August 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28782749/gall-bladder-flip-technique-in-laparoscopic-cholecystectomy
#15
Munish Sharma, Anubhav Vindal, Pawanindra Lal
BACKGROUND: The precise steps for the removal of gall bladder from the gall bladder bed are not well standardised. The dissection becomes more difficult near the fundus where the assistant's grasper holding the fundus creates a 'tug of war' like situation. MATERIALS AND METHODS: This is a description of a simple technique that aids in accurate dissection of the gallbladder from liver bed. As the gallbladder dissection approaches fundus and more than two-third of gallbladder is dissected from liver bed, the medial and lateral peritoneal folds of gall bladder are further incised...
August 1, 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28782025/observation-of-ultralong-valley-lifetime-in-wse2-mos2-heterostructures
#16
Jonghwan Kim, Chenhao Jin, Bin Chen, Hui Cai, Tao Zhao, Puiyee Lee, Salman Kahn, Kenji Watanabe, Takashi Taniguchi, Sefaattin Tongay, Michael F Crommie, Feng Wang
The valley degree of freedom in two-dimensional (2D) crystals recently emerged as a novel information carrier in addition to spin and charge. The intrinsic valley lifetime in 2D transition metal dichalcogenides (TMD) is expected to be markedly long due to the unique spin-valley locking behavior, where the intervalley scattering of the electron simultaneously requires a large momentum transfer to the opposite valley and a flip of the electron spin. However, the experimentally observed valley lifetime in 2D TMDs has been limited to tens of nanoseconds thus far...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28780854/structures-and-mechanisms-of-the-non-heme-fe-ii-and-2-oxoglutarate-dependent-ethylene-forming-enzyme-substrate-binding-creates-a-twist
#17
Salette Martinez, Matthias Fellner, Caitlyn Q Herr, Anastasia Ritchie, Jian Hu, Robert P Hausinger
The ethylene-forming enzyme (EFE) from Pseudomonas syringae pv. phaseolicola PK2 is a member of the mononuclear non-heme Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenase superfamily. EFE converts 2OG into ethylene plus three CO2 molecules while also catalyzing the C5 hydroxylation of L-arginine (L-Arg) driven by the oxidative decarboxylation of 2OG to form succinate and CO2. Here we report eleven X-ray crystal structures of EFE that provide insight into the mechanisms of these two reactions. Binding of 2OG in the absence of L-Arg resulted in predominantly monodentate metal coordination, distinct from the typical bidentate metal-binding species observed in other family members...
August 5, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28780125/effects-of-fullerene-on-lipid-bilayers-displaying-different-liquid-ordering-a-coarse-grained-molecular-dynamics-study
#18
Judit Sastre, Ilaria Mannelli, Ramon Reigada
BACKGROUND: The toxic effects and environmental impact of nanomaterials, and in particular of Fullerene particles, are matters of serious concern. It has been reported that fullerene molecules enter the cell membrane and occupy its hydrophobic region. Understanding the effects of carbon-based nanoparticles on biological membranes is therefore of critical importance to determine their exposure risks. METHODS: We report on a systematic coarse-grained molecular dynamics study of the interaction of fullerene molecules with simple model cell membranes...
August 2, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28777636/neural-decoder-for-topological-codes
#19
Giacomo Torlai, Roger G Melko
We present an algorithm for error correction in topological codes that exploits modern machine learning techniques. Our decoder is constructed from a stochastic neural network called a Boltzmann machine, of the type extensively used in deep learning. We provide a general prescription for the training of the network and a decoding strategy that is applicable to a wide variety of stabilizer codes with very little specialization. We demonstrate the neural decoder numerically on the well-known two-dimensional toric code with phase-flip errors...
July 21, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28777607/cat-codes-with-optimal-decoherence-suppression-for-a-lossy-bosonic-channel
#20
Linshu Li, Chang-Ling Zou, Victor V Albert, Sreraman Muralidharan, S M Girvin, Liang Jiang
We investigate cat codes that can correct multiple excitation losses and identify two types of logical errors: bit-flip errors due to excessive excitation loss and dephasing errors due to quantum backaction from the environment. We show that selected choices of logical subspace and coherent amplitude significantly reduce dephasing errors. The trade-off between the two major errors enables optimized performance of cat codes in terms of minimized decoherence. With high coupling efficiency, we show that one-way quantum repeaters with cat codes feature a boosted secure communication rate per mode when compared to conventional encoding schemes, showcasing the promising potential of quantum information processing with continuous variable quantum codes...
July 21, 2017: Physical Review Letters
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