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https://www.readbyqxmd.com/read/28822202/-q-marker-of-chinese-medicine-and-metabolic-regularity-of-co-network-compatibility-and-rainbow-potential
#1
Yan-Tao Yang, Sen Li, Jin-Ling Liu, Jin Zhou, Yi-Qun Zhou, Nai-Hong Chen, Fu-Yuan He
The effect of Chinese medicine (CM) compound prescription is the combined action results of single herbs based on the basic theory of Chinese medicine, and its function embodies the characteristics of multi components, multi targets and comprehensive effects. It is difficult to study the therapeutic material, establish quality standards or determine Q-marker, so we can't strictly monitor the quality of the whole process of CM. The identification of Q-marker has a profound influence on the whole process of the pharmaceutical engineering of CM...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28813512/implementation-of-a-comprehensive-intervention-for-patients-at-high-risk-of-cardiovascular-disease-in-rural-china-a-pragmatic-cluster-randomized-controlled-trial
#2
Xiaolin Wei, John D Walley, Zhitong Zhang, Guanyang Zou, Weiwei Gong, Simin Deng, Anthony D Harries, Joseph P Hicks, Marc K C Chong, James N Newell, Jieming Zhong, Min Yu
OBJECTIVE: This study aims to assess whether a standard intervention package of cardiovascular disease (CVD) care was being delivered effectively, and if it was associated with improved lifestyle and biomedical indicators. METHODS: In rural China, we implemented a pragmatic cluster randomized controlled trial for 12 months, randomized at the township hospital level, and compared with usual care. Intervention case management guideline, training and performance monitoring meeting and patient support activities were designed to fit within the job description of family doctors in the township hospitals and comprised: 1) prescription of a standardised package of medicines targeted at those with hypertension or diabetes; 2) advice about specific lifestyle interventions; and 3) advice about medication adherence...
2017: PloS One
https://www.readbyqxmd.com/read/28811907/factors-associated-with-antibiotic-prescriptions-for-the-viral-origin-diseases-in-office-based-practices-2006-2012
#3
Sara Imanpour, Obioma Nwaiwu, Darcy K McMaughan, Bethany DeSalvo, Adnan Bashir
OBJECTIVE: To test the potential association between time spent with a doctor and antibiotic overprescriptions in case of the common cold, runny nose, bronchitis, chest colds, flu, sore throats, and fluid in the middle ear. DESIGN: Cross-sectional study. SETTING: Office-based physicians in the US. PARTICIPANTS: A total of 261,623 patient visits recorded to office-based physicians in the US. MAIN OUTCOME MEASURES: The interest outcome was unnecessary antibiotic prescription...
August 2017: JRSM Open
https://www.readbyqxmd.com/read/28810899/chronic-pain-and-opioid-misuse-a-review-of-reviews
#4
REVIEW
Pauline Voon, Mohammad Karamouzian, Thomas Kerr
OBJECTIVE: The crisis of prescription opioid (PO) related harms has focused attention toward identifying and treating high-risk populations. This review aims to synthesize systematic reviews on the epidemiology and clinical management of comorbid chronic pain and PO or other substance misuse. METHODS: A systematic database search was conducted to identify systematic reviews published between 2000 and 2016. Eligible studies were systematic reviews related to chronic non-cancer pain and PO or other substance misuse...
August 15, 2017: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/28807651/recommendations-for-the-prescription-of-physical-exercise-for-patients-with-spondyloarthritis
#5
Mariano Tomás Flórez García, Loreto Carmona, Raquel Almodóvar, César Fernández de Las Peñas, Fernando García Pérez, M Ángeles Pérez Manzanero, José Manuel García García, Lidón Soriano Segarra, José Fernando Jiménez Díaz, Nuria Mendoza Laiz, Eugenio de Miguel Mendieta, Juan Carlos Torre Alonso, Luis Francisco Linares Ferrando, Eduardo Collantes Estévez, Jesús Sanz Sanz, Pedro Zarco Montejo
OBJECTIVE: To develop expert-based recommendations on physical activity and exercise for patients with spondyloarthritis (SpA). METHODS: Two discussion groups, one of physical therapists, rehabilitation physicians, and professionals of physical activity and sports, and another of rheumatologists interested in SpA, were held to discuss the results of a survey of rheumatologists on exercise and two focus groups with patients on barriers to exercise. Preliminary recommendations were drafted...
August 11, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28807135/suicidal-ideation-and-suicidal-self-directed-violence-following-clinician-initiated-prescription-opioid-discontinuation-among-long-term-opioid-users
#6
Michael I Demidenko, Steven K Dobscha, Benjamin J Morasco, Thomas H A Meath, Mark A Ilgen, Travis I Lovejoy
OBJECTIVE: Little is known about patient outcomes following discontinuation of opioid therapy, which may include suicidal ideation (SI) and suicidal self-directed violence (SSV). The purpose of this study was to examine correlates of SI and non-fatal SSV in a sample of patients discontinued from long-term opioid therapy (LTOT). METHOD: Five hundred-nine Veterans Health Administration (VHA) patients whose clinicians discontinued them from LTOT were selected from a national cohort of VHA patients who discontinued opioids in 2012...
July 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28806902/monitoring-documenting-and-reporting-the-quality-of-antibiotic-use-in-the-netherlands-a-pilot-study-to-establish-a-national-antimicrobial-stewardship-registry
#7
Marvin Ah Berrevoets, Jaap Ten Oever, Tom Sprong, Reinier M van Hest, Ingeborg Groothuis, Inger van Heijl, Jeroen A Schouten, Marlies E Hulscher, Bart-Jan Kullberg
BACKGROUND: The Dutch Working Party on Antibiotic Policy is developing a national antimicrobial stewardship registry. This registry will report both the quality of antibiotic use in hospitals in the Netherlands and the stewardship activities employed. It is currently unclear which aspects of the quality of antibiotic use are monitored by antimicrobial stewardship teams (A-teams) and can be used as indicators for the stewardship registry. In this pilot study we aimed to determine which stewardship objectives are eligible for the envisioned registry...
August 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28802217/comparatively-evaluating-the-pharmacokinetic-of-fifteen-constituents-in-normal-and-blood-deficiency-rats-after-oral-administration-of-xin-sheng-hua-granule-by-uplc-ms-ms
#8
Han-Qing Pang, Yu-Ping Tang, Yu-Jie Cao, Ya-Jie Tan, Yi Jin, Xu-Qin Shi, Sheng-Liang Huang, Da-Zheng Sun, Jin Sun, Zhi-Shu Tang, Jin-Ao Duan
Xin-Sheng-Hua Granule (XSHG), a famous traditional Chinese medicine prescription, are clinically applied for the treatment of postpartum disease through nourishing blood and promoting blood circulation. In this investigation, a multi-constituents (trigonelline, stachydrine hydrochloride, hydroxysafflor yellow A, chlorogenic acid, amygdalin, leonurine, liquiritin, ferulic acid, senkyunolide I, senkyunolide H, glycyrrhizic acid, senkyunolide A, ligustilide, butylidenephthalide and glycyrrhetinic acid) pharmacokinetic study of XSHG was conducted for the first time...
July 30, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28801284/-yiqihuoxue-prescription-promotes-nerve-regeneration-by-mir-124-mediated-regulation-of-wnt-signaling-in-rats
#9
Hui Tan, Jian Wang, Ting-Ting Yin, Ling He, Yong Deng, Feng Li, Yu-Feng Wang
OBJECTIVE: To investigate the effect of Yiqihuoxue prescription (NLXT) on nerve regeneration in MCAO-R rat models of qi deficiency and blood stasis syndrome and explore the underlying mechanisms. METHODS: The rats were randomized into 4 groups, namely the control group, model group, NLXT group and TXL group. The rats in NLXT group and TXL group were treated with gavage of NLXT and TXL solutions, respectively. The NFDS, QDSS and BSSS of the rats were evaluated. The regional cerebral blood flow (rCBF) were dynamically monitored with laser Doppler scanning, and the volume of cerebral infarction was detected with TTC-dye; the expression levels of nestin and BrdU were assayed with immunohistochemistry and mmunofluorescent staining...
August 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28796376/neuropsychiatric-adverse-events-of-antiepileptic-drugs-in-brain-tumour-related-epilepsy-an-italian-multicentre-prospective-observational-study
#10
C Bedetti, M Romoli, M Maschio, C Di Bonaventura, E Nardi Cesarini, P Eusebi, S Siliquini, S Dispenza, P Calabresi, C Costa
BACKGROUND AND PURPOSE: We assessed the prevalence and magnitude of neuropsychiatric adverse events (NPAEs) associated with antiepileptic drugs (AEDs) among patients with brain tumour-related epilepsy (BTRE). METHODS: This observational, prospective, multicentre study enrolled 259 patients with BTRE after neurosurgery. All patients received AED monotherapy. Efficacy was assessed through clinical diaries, whereas NPAEs were collected using the Neuropsychiatric Inventory Test-12 questionnaire at baseline and after 5 months...
August 10, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28791598/opioid-medications-in-the-management-of-chronic-abdominal-pain
#11
REVIEW
Dajie Wang
PURPOSE OF REVIEW: Chronic abdominal pain is a complex medical condition. The causes of chronic abdominal pain are extremely diverse ranging from chronic pancreatitis, Crohn's disease, to chronic pain with no clear etiology. Treatment of chronic abdominal pain remains a challenge in our clinical practice. While current interventions with celiac plexus blocks and pain medications provide some relief for these patients, but these treatments are typically less efficacious and limited by various adverse effects...
August 8, 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/28790187/antibiotic-susceptibility-testing-in-less-than-30-min-using-direct-single-cell-imaging
#12
Özden Baltekin, Alexis Boucharin, Eva Tano, Dan I Andersson, Johan Elf
The emergence and spread of antibiotic-resistant bacteria are aggravated by incorrect prescription and use of antibiotics. A core problem is that there is no sufficiently fast diagnostic test to guide correct antibiotic prescription at the point of care. Here, we investigate if it is possible to develop a point-of-care susceptibility test for urinary tract infection, a disease that 100 million women suffer from annually and that exhibits widespread antibiotic resistance. We capture bacterial cells directly from samples with low bacterial counts (10(4) cfu/mL) using a custom-designed microfluidic chip and monitor their individual growth rates using microscopy...
August 8, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28780607/strategies-to-identify-and-reduce-opioid-misuse-among-patients-with-gastrointestinal-disorders-a-systematic-scoping-review
#13
REVIEW
Salva N Balbale, Itishree Trivedi, Linda C O'Dwyer, Megan C McHugh, Charlesnika T Evans, Neil Jordan, Laurie A Keefer
BACKGROUND: Scoping reviews are preliminary assessments intended to characterize the extent and nature of emerging research evidence, identify literature gaps, and offer directions for future research. We conducted a systematic scoping review to describe published scientific literature on strategies to identify and reduce opioid misuse among patients with gastrointestinal (GI) symptoms and disorders. METHODS: We performed structured keyword searches to identify manuscripts published through June 2016 in the PubMed MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Scopus, and Web of Science databases to extract original research articles that described healthcare practices, tools, or interventions to identify and reduce opioid misuse among GI patients...
August 5, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28770590/delivering-hiv-care-in-challenging-operating-environments-the-msf-experience-towards-differentiated-models-of-care-for-settings-with-multiple-basic-health-care-needs
#14
REVIEW
Charles Ssonko, Lucia Gonzalez, Anita Mesic, Marcio Silveira da Fonseca, Jay Achar, Nadia Safar, Beatriz Martin, Sidney Wong, Esther C Casas
INTRODUCTION: Countries in the West and Central African regions struggle to offer quality HIV care at scale, despite HIV prevalence being relatively low. In these challenging operating environments, basic health care needs are multiple, systems are highly fragile and conflict disrupts health care. Médecins Sans Frontières (MSF) has been working to integrate HIV care in basic health services in such settings since 2000. We review the implementation of differentiated HIV care and treatment approaches in MSF-supported programmes in South Sudan (RoSS), Central African Republic (CAR) and Democratic Republic of Congo (DRC)...
July 21, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28765547/simultaneous-determination-of-hydrophilic-and-lipophilic-constituents-in-herbal-medicines-using-directly-coupled-reversed-phase-and-hydrophilic-interaction-liquid-chromatography-tandem-mass-spectrometry
#15
Wan-Yang Sun, Qin-Wei Lu, Hao Gao, Ling Tong, Dong-Xiang Li, Zheng-Qun Zhou, Zheng-Jin Jiang, Henry Sun, Kai-Shun Bi
Limitations in the separation ability of conventional liquid chromatography system remains a challenge in developing a versatile method for simultaneously determining both hydrophilic and lipophilic constituents in herbal medicines (HMs). To measure compounds covering a broad polarity span in HMs, we developed a directly-coupled reversed-phase and hydrophilic interaction liquid chromatography-tandem mass spectrometry system. Samples were firstly separated according to lipophilicity by using a C18 column. Utilizing a T-piece as connector, the eluent was then pumped into an amide column to get further separation that mainly based on the hydrogen bonding effects...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28761700/a-novel-treadmill-protocol-for-exercise-testing-in-children-the-british-columbia-children-s-hospital-protocol
#16
D Kathryn Duff, Astrid M De Souza, Derek G Human, James E Potts, Kevin C Harris
BACKGROUND: Exercise testing in children is widely recommended for a number of clinical and prescriptive reasons. Many institutions continue to use the Bruce protocol for treadmill testing; however, with its incremental changes in speed and grade, it has challenges for practical application in children. We have developed a novel institutional protocol (British Columbia Children's Hospital (BCCH)), which may have better utility in paediatric populations. AIM: To determine if our institutional protocol yields similar peak responses in minute ventilation (VE), oxygen consumption (VO2), carbon dioxide production (VCO2), respiratory exchange ratio (RER), metabolic equivalents (METS) and heart rate (HR) when compared with the traditional Bruce protocol...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/28760791/prevalence-and-prescription-patterns-of-oral-glucocorticoids-in-adults-a-retrospective-cross-sectional-and-cohort-analysis-in-france
#17
Anne Bénard-Laribière, Antoine Pariente, Elodie Pambrun, Bernard Bégaud, Laurence Fardet, Pernelle Noize
OBJECTIVES: To study trends in use of oral glucocorticoids (GCs) among adults, characteristics of oral GC initiators and prescriptions for the prevention of potential adverse effects associated with GC therapy. DESIGN: First, a cross-sectional study repeated yearly was performed from 2007 to 2014 in a nationwide representative sample. Second, characteristics of initiators and patterns of GC therapy during the year following treatment initiation were described in a cohort of patients who began GC between 2007 and 2013...
July 31, 2017: BMJ Open
https://www.readbyqxmd.com/read/28758027/australasian-society-for-hiv-viral-hepatitis-and-sexual-health-medicine-hiv-pre-exposure-prophylaxis-clinical-guidelines
#18
EDITORIAL
Edwina Wright, Andrew Grulich, Katy Roy, Mark Boyd, Vincent Cornelisse, Darren Russell, Darryl O'Donnell, Bill Whittaker, Levinia Crooks, Iryna Zablotska
Daily use of coformulated tenofovir and emtricitabine for HIV pre-exposure prophylaxis (PrEP) by populations at high risk of HIV infection is now recommended in guidelines from the United States, Europe and Australia and globally through the 2015 WHO guidelines. These 2017 Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine's (ASHM) PrEP Guidelines are an updated adaptation of the 2014 US Centers for Disease Control's PrEP guidelines and are designed to: •Support the prescription of PrEP using forms of coformulated tenofovir and emtricitabine that have been registered in Australia by the Therapeutic Goods Administration and other bioequivalent generic drugs that are available in Australia through self-importation, private prescription or Australian PrEP clinical trials•Assist clinicians in the evaluation of patients who are seeking PrEP•Assist clinicians in commencing and monitoring patients on PrEP including PrEP dosing schedules, management of side-effects and toxicity, use of PrEP in pregnancy and in chronic hepatitis B infection and how to cease PrEP Daily PrEP with co-formulated tenofovir and emtricitabine, used continuously or for shorter periods of time, is recommended in these guidelines as a key HIV-prevention option for men who have sex with men (MSM), transgender men and women, heterosexual men and women, and people who inject drugs (PWID) at substantial risk of HIV acquisition...
July 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28756692/the-safety-of-available-treatments-for-chronic-constipation
#19
Blanca Serrano-Falcon, Enrique Rey
INTRODUCTION: Chronic constipation is a frequent syndrome which, not only causes an appreciable deterioration in quality of life, but also entails a high economic cost due, among other things, to its treatment. This is because of the widespread use of laxatives, even by subjects who have not sought medical care, as well as little patient satisfaction with the treatment. Although this generally involves the use of drugs regarded as safe, there is no clear evidence about their short- and long-term effects, something that complicates appropriate prescription and follow-up by health professionals and hinders therapeutic compliance...
July 31, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28755801/international-trends-in-antipsychotic-use-a-study-in-16-countries-2005-2014
#20
Óskar Hálfdánarson, Helga Zoëga, Lise Aagaard, Miquel Bernardo, Lena Brandt, Anna Coma Fusté, Kari Furu, Kristina Garuoliené, Falk Hoffmann, Krista F Huybrechts, Luuk J Kalverdijk, Koji Kawakami, Helle Kieler, Takuya Kinoshita, Melisa Litchfield, Soffy C López, Jorge E Machado-Alba, Manuel E Machado-Duque, Mufaddal Mahesri, Prasad S Nishtala, Sallie-Anne Pearson, Johan Reutfors, Leena K Saastamoinen, Izumi Sato, Catharina C M Schuiling-Veninga, Yu-Chiau Shyu, Svetlana Skurtveit, Hélène Verdoux, Liang-Jen Wang, Corinne Zara Yahni, Christian J Bachmann
The objective of this study was to assess international trends in antipsychotic use, using a standardised methodology. A repeated cross-sectional design was applied to data extracts from the years 2005 to 2014 from 16 countries worldwide. During the study period, the overall prevalence of antipsychotic use increased in 10 of the 16 studied countries. In 2014, the overall prevalence of antipsychotic use was highest in Taiwan (78.2/1000 persons), and lowest in Colombia (3.2/1000). In children and adolescents (0-19 years), antipsychotic use ranged from 0...
July 27, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
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