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https://www.readbyqxmd.com/read/28644216/what-do-pas-need-to-know-about-prescription-drug-monitoring-programs
#1
Geoffrey A Mospan, Austin Lucas
As controlled-substance abuse continues to increase in the United States, clinicians find themselves on the front lines of this epidemic. State-operated prescription drug monitoring programs are a valuable resource that prescribers can use to see patients' controlled substance history. Despite some limitations, these programs have been shown to be an effective method in reducing overdose deaths and the supply of controlled substances in the community.
July 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28641687/preparing-safety-cases-for-operating-outside-prescriptive-fatigue-risk-management-regulations
#2
Philippa Gander, Jim Mangie, Lora Wu, Margo van den Berg, Leigh Signal, Adrienne Phillips
INTRODUCTION: Transport operators seeking to operate outside prescriptive fatigue management regulations are typically required to present a safety case justifying how they will manage the associated risk. This paper details a method for constructing a successful safety case. METHODS: The method includes four elements: 1) scope (prescriptive rules and operations affected); 2) risk assessment; 3) risk mitigation strategies; and 4) monitoring ongoing risk. A successful safety case illustrates this method...
July 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28640773/salivary-mitochondrial-dna-copy-number-is-associated-with-exercise-ventilatory-efficiency
#3
Yang Chen, Helene Z Hill, Gudrun Lange, Michael J Falvo
Chen, Y, Hill, HZ, Lange, G, and Falvo, MJ. Salivary mitochondrial DNA copy number is associated with exercise ventilatory efficiency. J Strength Cond Res 31(7): 2000-2004, 2017-Mitochondrial DNA copy number (mtDNAcn) is an index of mitochondrial content and is responsive to changes in exercise training volume. Therefore, assessment of mtDNAcn may help to optimize exercise prescription and aid in athlete monitoring. Although previous work has assessed mtDNAcn derived from skeletal muscle and blood using invasive approaches, no study has examined salivary mtDNAcn and its relationship with sport performance...
July 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28635169/potential-drug-drug-interactions-in-older-adults-a-population-based-study
#4
Thalyta Renata Araújo Santos, Erika Aparecida Silveira, Lílian Varanda Pereira, Mércia Pandolfo Provin, Dione Marçal Lima, Rita Goreti Amaral
AIM: To evaluate the potential drug-drug interactions (PDDI) between drugs used by older adults, any associated factors and recommended clinical management. METHODS: A cross-sectional, population-based study was carried out through a home survey of 934 older adults (from December 2009 to April 2010). A questionnaire was applied, and the participants were asked to show all the drugs used and their respective prescriptions, thus providing data to identify polypharmacy, self-medication and PDDI...
June 21, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28634456/absolute-and-relative-training-load-and-its-relation-to-fatigue-in-football
#5
Unai Zurutuza, Julen Castellano, Ibon Echeazarra, David Casamichana
The aim of the study was to assess the relationship of external and internal training load (TL) indicators with the objective and subjective fatigue experienced by 15 semi-professional football players, over eight complete weeks of the competition period in the 2015-2016 season, which covered microcycles from 34th to 41st. The maximum heart rate (HRmax) and maximum speed (Vmax) of all the players were previously measured in specific tests. The TL was monitored via questionnaires on rating of perceived exertion (RPE), pulsometers and GPS devices, registering the variables: total distance (TD), player load 2D (PL2D), TD at >80% of the Vmax (TD80), TD in deceleration at < -2 m⋅sec-2 (TDD <-2), TD in acceleration >2 m⋅sec(-2) (TDA >2), Edwards (ED), time spent at between 50 and 80% (50-80% HRmax), 80-90% (80-90% HRmax), and >90% of the HRmax (>90% HRmax), and RPE both respiratory/thoracic (RPEres) and leg/muscular (RPEmus)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28633638/evaluating-the-impact-of-prescription-drug-monitoring-program-implementation-a-scoping-review
#6
Erin P Finley, Ashley Garcia, Kristen Rosen, Don McGeary, Mary Jo Pugh, Jennifer Sharpe Potter
BACKGROUND: Prescription drug monitoring programs (PDMPs) have been implemented in 49 out of 50 states in an effort to reduce opioid-related misuse, abuse, and mortality, yet the literature evaluating the impact of PDMP implementation remains limited. We conducted a scoping review to: (1) describe available evidence regarding impact of PDMPs in the U.S.; and (2) propose a conceptual model to inform future PDMP implementation and evaluation efforts. METHODS: Scoping systematic review following Arksey and O'Malley's (2005) methodology...
June 20, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28628866/anticancer-drugs-consumption-trends-in-spain-prediction-of-environmental-concentrations-and-potential-risks
#7
Helena Franquet-Griell, Cristian Gómez-Canela, Francesc Ventura, Silvia Lacorte
This study presents the occurrence and impact of 78 anticancer drugs in Spanish river basins based on consumption data in pharmacies during the period 2010-2015 and calculation of the predicted environmental concentrations (PEC). The total consumption of anticancer drugs in Spanish pharmacies was of 23.4 tons in 2015, being mycophenolic acid and hydroxycarbamide the drugs with the highest prescription. Their PECs in river at national scale were up to 80 ng/L. However, the use of different dilution factors revealed major differences between hydrographic basins, and PECriver rose up to 68,014 ng/L in highly populated rivers with low flows...
June 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28628527/antiretroviral-prescription-and-viral-suppression-in-a-representative-sample-of-hiv-infected-persons-in-care-in-four-large-metropolitan-areas-of-the-united-states-medical-monitoring-project-2011-figure-dash-2013
#8
Amy Rock Wohl, Nanette Benbow, Judith Tejero, Christopher Johnson, Susan Scheer, Kathleen Brady, Alexandra Gagner, Alison Hughes, Michael Eberhart, Christine Mattson, Jacek Skarbinski
BACKGROUND: Comparisons of ART prescription and viral suppression among people in HIV care across U.S. metropolitan areas are limited. 2011-2013 Medical Monitoring Project data were used to describe and compare associations between socio-demographics and ART prescription and viral suppression for persons receiving HIV care. SETTING: Chicago, Los Angeles County (LAC), Philadelphia, and San Francisco in the United States. METHODS: Bivariate and multivariable methods were used...
June 15, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28627250/exploring-the-frequency-domain-of-continuous-glucose-monitoring-signals-to-improve-characterization-of-glucose-variability-and-of-diabetic-profiles
#9
Giuseppe Fico, Liss Hernández, Jorge Cancela, Miguel María Isabel, Andrea Facchinetti, Chiara Fabris, Rafael Gabriel, Claudio Cobelli, María Teresa Arredondo Waldmeyer
BACKGROUND: Continuous glucose monitoring (CGM) devices measure interstitial glucose concentrations (normally every 5 minutes), allowing observation of glucose variability (GV) patterns during the whole day. This information could be used to improve prescription of treatments and of insulin dosages for people suffering diabetes. Previous efforts have been focused on proposing indices of GV either in time or glucose domains, while the frequency domain has been explored only partially. The aim of this work is to explore the CGM signal in the frequency domain to understand if new indexes or features could be identified and contribute to a better characterization of glucose variability...
January 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28627150/-applying-a-set-of-indicators-to-evaluate-the-primary-health-care
#10
Antonio Giampietro Russo, Maria Teresa Greco
OBJECTIVES: to develop a system of indicators to monitor the quality of health care, in terms of safety, effectiveness, and appropriateness to allow the integrated promotion of the welfare of the effectiveness and quality. DESIGN: retrospective study. SETTING AND PARTICIPANTS: all general practitioners (GPs) with at least 100 patients in loading at 1.1.2015 were included. The setting chosen is the Primary Care of the Agency for Health Protection of the Province of Milan (Northern Italy)...
January 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28626996/vortex-ultrasound-assisted-dispersive-liquid-liquid-microextraction-coupled-with-gc-ms-for-the-analysis-of-volatile-bioactive-components-and-comparative-pharmacokinetic-study-of-the-herb-herb-interactions-in-guanxin-shutong-capsule
#11
Jingqing Mu, Xun Gao, Qing Li, Xiaomei Yang, Wenling Yang, Xu Sun, Kaishun Bi, Huifen Zhang
Guanxin Shutong Capsule, an effective traditional Chinese medicine, is widely used for coronary heart disease clinically. Volatile components are one of its important bioactive constituents. To better understand the material basis for the therapeutic effects, the components of Guanxin Shutong Capsule absorbed into the blood and their metabolites were identified based on gas chromatography with mass spectrometry coupled with vortex-ultrasound-assisted dispersive liquid-liquid microextraction. As a result, three prototypes and 15 metabolites were identified or tentatively characterized in rat plasma...
June 19, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28623381/-the-use-of-prescription-drugs-with-dependence-potential-in-germany-a-prospective-analysis-of-prescriptions-in-the-public-healthcare-system-between-2006-and-2010
#12
Sven Buth, Rüdiger Holzbach, Moritz Rosenkranz, Uwe Verthein
BACKGROUND: In Germany, about 1.4 to 2.6 million people are dependent on prescription drugs, mainly benzodiazepine derivatives and opioid analgesics. Despite this large number of affected people, studies on prescription behaviour and drug intake are scarce. There are particularly few empirical findings available with regard to elderly people age 65 and over who are disproportionally affected by prescription drug abuse. METHODS: The North German Pharmacy Computing Centre (Norddeutsches Apothekenrechenzentrum, NARZ) collects the prescription data of about 11 million citizens and covers over 80% of drug pharmacies in North Germany...
June 16, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28622079/use-of-an-automated-mobile-phone-messaging-robot-in-postoperative-patient-monitoring
#13
Chris A Anthony, Ericka A Lawler, Christina M Ward, Ines C Lin, Apurva S Shah
BACKGROUND: Mobile phone messaging software robots allow clinicians and healthcare systems to communicate with patients without the need for human intervention. The purpose of this study was to (1) describe a method for communicating with patients postoperatively outside of the traditional healthcare setting by utilizing an automated software and mobile phone messaging platform and to (2) evaluate the first week of postoperative pain and opioid use after common ambulatory hand surgery procedures...
June 16, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28620408/quality-control-of-the-traditional-patent-medicine-yimu-wan-based-on-smrt-sequencing-and-dna-barcoding
#14
Jing Jia, Zhichao Xu, Tianyi Xin, Linchun Shi, Jingyuan Song
Substandard traditional patent medicines may lead to global safety-related issues. Protecting consumers from the health risks associated with the integrity and authenticity of herbal preparations is of great concern. Of particular concern is quality control for traditional patent medicines. Here, we establish an effective approach for verifying the biological composition of traditional patent medicines based on single-molecule real-time (SMRT) sequencing and DNA barcoding. Yimu Wan (YMW), a classical herbal prescription recorded in the Chinese Pharmacopoeia, was chosen to test the method...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28619128/bioimpedance-based-rather-than-weight-based-ultrafiltration-prescription-for-children-on%C3%A2-maintenance-hemodialysis%C3%A2
#15
Gianluigi Ardissino, Mirco Belingheri, Michela Perrone, Francesca Tel, Dario Consonni, Sara Testa
The determination of dry weight (DW) in young children on hemodialysis (HD) remains challenging. Bioimpedance analysis (BIA) is a potentially helpful means of estimating the need for ultrafiltration and monitoring body fluids in patients on renal replacement therapy, but its role has not yet been clearly defined. The aim of this paper is to share our experience of prescribing ultrafiltration on the basis of BIA parameters alone. The body weight (BW), resistance (Rx), and reactance (Xc) of a 3-year-old girl on chronic HD were recorded pre- and post-HD over a period of 16 months...
June 16, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28616249/quality-of-care-for-patients-with-chronic-kidney-disease-in-the-primary-care-setting-a-retrospective-cohort-study-from-ontario-canada
#16
Danielle M Nash, Scott Brimble, Maureen Markle-Reid, Eric McArthur, Karen Tu, Gihad E Nesrallah, Allan Grill, Amit X Garg
BACKGROUND: Patients with chronic kidney disease may not be receiving recommended primary renal care. OBJECTIVE: To use recently established primary care quality indicators for chronic kidney disease to determine the proportion of patients receiving recommended renal care. DESIGN: Retrospective cohort study using administrative data with linked laboratory information. SETTING: The study was conducted in Ontario, Canada, from 2006 to 2012...
2017: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/28615765/adverse-drug-reaction-monitoring-in-a-tertiary-care-psychiatry-setting-a-comparative-study-between-inpatients-and-outpatients
#17
Tejaswi Gummadi, Virupaksha Shanmugam Harave, Lakshmi Narayan Aiyar, Saraswathy Ganesan RajaLekshmi, Radhika Kunnavil
BACKGROUND: Psychotropic medications are the mainstay of treatment in psychiatric disorders and are associated with ADRs which affect the compliance and treatment course. Previous studies have looked at the frequency, profile of ADRs and their management aspects. However, the systematic comparison between IP and OP was lacking even though there is a prescription pattern difference. Hence this study was aimed to compare the proportion, pattern, severity and resolution of ADRs once detected...
May 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28615272/what-do-adolescents-with-asthma-really-think-about-adherence-to-inhalers-insights-from-a-qualitative-analysis-of-a-uk-online-forum
#18
Anna De Simoni, Robert Horne, Louise Fleming, Andrew Bush, Chris Griffiths
OBJECTIVE: To explore the barriers and facilitators to inhaled asthma treatment in adolescents with asthma. DESIGN: Qualitative analysis of posts about inhaler treatment in adolescents from an online forum for people with asthma. Analysis informed by the Perceptions and Practicalities Approach. PARTICIPANTS: Fifty-four forum participants (39 adolescents ≥16 years, 5 parents of adolescents, 10 adults with asthma) identified using search terms 'teenager inhaler' and 'adolescent inhaler'...
June 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28607686/improving-care-for-patients-with-or-at-risk-for-chronic-kidney-disease-using-electronic-medical-record-interventions-a-pragmatic-cluster-randomized-trial-protocol
#19
Danielle M Nash, Noah M Ivers, Jacqueline Young, R Liisa Jaakkimainen, Amit X Garg, Karen Tu
BACKGROUND: Many patients with or at risk for chronic kidney disease (CKD) in the primary care setting are not receiving recommended care. OBJECTIVE: The objective of this study is to determine whether a multifaceted, low-cost intervention compared with usual care improves the care of patients with or at risk for CKD in the primary care setting. DESIGN: A pragmatic cluster-randomized trial, with an embedded qualitative process evaluation, will be conducted...
2017: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/28607667/cardiovascular-and-cerebrovascular-risk-with-nonsteroidal-anti-inflammatory-drugs-and-cyclooxygenase-2-inhibitors-latest-evidence-and-clinical-implications
#20
REVIEW
Andrea Fanelli, Daniela Ghisi, Pierangelo Lora Aprile, Francesco Lapi
Observational studies and meta-analyses have shown that the administration of nonsteroidal anti-inflammatory drugs (NSAIDs), especially when prescribed at high doses for long periods of time, can potentially increase the risk of cardiovascular diseases. The increased thrombotic risk related to the use of NSAIDs is mainly due to their cyclooxygenase 2 selectivity. The dosage use, the formulation selected and the duration of the therapy are other factors that can significantly impact on the cardiovascular risk...
June 2017: Therapeutic Advances in Drug Safety
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