Jesús F García-Gavilán, Alessandro Atzeni, Nancy Babio, Liming Liang, Clara Belzer, Jesús Vioque, Dolores Corella, Montserrat Fitó, Josep Vidal, Isabel Moreno-Indias, Laura Torres-Collado, Oscar Coltell, Estefanía Toledo, Clary Clish, Javier Hernando, Huan Yun, Adrián Hernández-Cacho, Sarah Jeanfavre, Courtney Dennis, Ana M Gómez-Pérez, Maria Angeles Martínez, Miguel Ruiz Canela, Francisco J Tinahones, Frank B Hu, Jordi Salas-Salvadó
BACKGROUND: The health benefits of the Mediterranean diet (MedDiet) have been linked to the presence of beneficial gut microbes and related metabolites. However, its impact on the fecal metabolome remains poorly understood. OBJECTIVE: Our goal was to investigate the weight loss effects of a 1-year lifestyle intervention based on an energy-reduced MedDiet coupled with physical activity (intervention group), compared to an ad libitum MedDiet (control group), on fecal metabolites, fecal microbiota, and their potential association with cardiovascular risk factors METHODS: A total of 400 participants (200 from each study group), aged 55-75 years, and at high cardiovascular risk, were included...
February 28, 2024: American Journal of Clinical Nutrition