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Nervous system lyme disease

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https://www.readbyqxmd.com/read/29723263/borrelia-burgdorferi-adhere-to-blood-vessels-in-the-dura-mater-and-are-associated-with-increased-meningeal-t-cells-during-murine-disseminated-borreliosis
#1
Ali Divan, Timothy Casselli, S Anand Narayanan, Sanjib Mukherjee, David C Zawieja, John A Watt, Catherine A Brissette, M Karen Newell-Rogers
Borrelia burgdorferi, the causative agent of Lyme disease, is a vector-borne bacterial infection that is transmitted through the bite of an infected tick. If not treated with antibiotics during the early stages of infection, disseminated infection can spread to the central nervous system (CNS). In non-human primates (NHPs) it has been demonstrated that the leptomeninges are among the tissues colonized by B. burgdorferi spirochetes. Although the NHP model parallels aspects of human borreliosis, a small rodent model would be ideal to study the trafficking of spirochetes and immune cells into the CNS...
2018: PloS One
https://www.readbyqxmd.com/read/29706150/neurosyphilis-mighty-imitator-forays-with-benign-presentation-and-unique-neuroimaging-findings
#2
Harmanpreet Tiwana, Aiesha Ahmed
Background: Common causes of temporal lobe hyper intensities are central nervous system infections like herpes simplex encephalitis, Lyme disease, limbic encephalitis and vascular pathology like Cerebral Autosomal Dominant Arteriopathy with Subcortical infarcts and Leukoencephalopathy. Methods: Personal assessment, laboratory data analysis and neuroimaging for the patient who was admitted to a central Pennsylvania tertiary care referral centre were conducted. Results: A 52-year-old male presented with a 1-year history of diffuse dysesthesia in upper and lower extremities with associated intermittent headaches and neck stiffness...
April 30, 2018: Sexual Health
https://www.readbyqxmd.com/read/29613895/infectious-myelopathies
#3
Marie F Grill
PURPOSE OF REVIEW: This article reviews bacterial, viral, fungal, and parasitic pathogens associated with myelopathy. Infectious myelopathies may be due to direct infection or parainfectious autoimmune-mediated mechanisms; this article focuses primarily on the former. RECENT FINDINGS: Some microorganisms exhibit neurotropism for the spinal cord (eg, enteroviruses such as poliovirus and flaviviruses such as West Nile virus), while others are more protean in neurologic manifestations (eg, herpesviruses such as varicella-zoster virus), and others are only rarely reported to cause myelopathy (eg, certain fungal and parasitic infections)...
April 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29595012/-lyme-disease-or-not
#4
A Salmon, A de Noordhout Maertens, F Moerman
Lyme disease is a complex pathology due to an infection by a spirochaete from the genus Borrelia. This infection results from a tick bite lasting more than 24 hours. Signs and symptoms are numerous and are usually classified in three stages: early localized disease, early disseminated disease and late disease. The skin, the heart, the nervous system and the joints are mostly concerned. It is important to distinguish the clinical manifestations of the disease from those that are sometimes associated with it but with no scientific evidence...
March 2018: Revue Médicale de Liège
https://www.readbyqxmd.com/read/29460492/cerebrospinal-fluid-lyme-multiplex-assay-results-are-not-diagnostic-in-horses-with-neuroborreliosis
#5
Amy L Johnson, Laura K Johnstone, Darko Stefanovski
BACKGROUND: The accuracy of the Lyme multiplex assay for the diagnosis of neuroborreliosis in horses is unknown. HYPOTHESIS/OBJECTIVES: To describe Lyme multiplex results in horses with a postmortem diagnosis of neuroborreliosis. The hypothesis was that paired serum and cerebrospinal fluid (CSF) results and a CSF : serum ratio would allow differentiation of horses with neuroborreliosis from those with other neurologic diseases. ANIMALS: Ninety horses that had neurologic examinations, serum and CSF Lyme multiplex analyses, and postmortem examination of the nervous system performed...
March 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29408631/intracellular-tlr7-is-activated-in-human-oligodendrocytes-in-response-to-borrelia-burgdorferi-exposure
#6
Geetha Parthasarathy, Mario T Philipp
Lyme neuroborreliosis, caused by the gram-negative bacterium Borrelia burgdorferi, may affect the central and/or peripheral nervous systems. In previous studies, we showed that human oligodendrocytes exposed to the bacteria undergo apoptosis in an inflammatory environment, and that inflammatory pathways trigger cell-death pathways. We further demonstrated that several receptor tyrosine kinases were involved in triggering downstream effects, leading to inflammation and apoptosis. Toll-like receptors TLR2 and TLR5, which are commonly studied receptors in Lyme disease, only had a minimal role in inflammatory processes...
April 3, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29317049/autoimmunity-against-a-glycolytic-enzyme-as-a-possible-cause-for-persistent-symptoms-in-lyme-disease
#7
Paolo Maccallini, Serena Bonin, Giusto Trevisan
Some patients with a history of Borrelia burgdorferi infection develop a chronic symptomatology characterized by cognitive deficits, fatigue, and pain, despite antibiotic treatment. The pathogenic mechanism that underlines this condition, referred to as post-treatment Lyme disease syndrome (PTLDS), is currently unknown. A debate exists about whether PTLDS is due to persistent infection or to post-infectious damages in the immune system and the nervous system. We present the case of a patient with evidence of exposure to Borrelia burgdorferi sl and a long history of debilitating fatigue, cognitive abnormalities and autonomic nervous system issues...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29278020/diagnosis-and-management-of-lyme-neuroborreliosis
#8
John J Halperin
The nervous system is involved in 10-15% of patients infected with B. burgdorferi, B. afzelii and B. garinii. This review will address widespread misconceptions about the clinical phenomenology, diagnostic approach and response to treatment of neuroborreliosis. Areas covered: Improvements in diagnostic testing have allowed better definition of the clinical spectrum of neuroborreliosis, with lymphocytic meningitis and uni- or multifocal inflammation of peripheral/cranial nerves predominating. Despite widespread concern that post-treatment cognitive/behavioral symptoms might be attributable to persisting infection or aberrant inflammation within the central nervous system a large body of evidence indicates this is extremely improbable...
January 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29225980/early-disseminated-lyme-disease-with-carditis-complicated-by-posttreatment-lyme-disease-syndrome
#9
Cheryl Novak, Andrew Harrison, John Aucott
Lyme disease is an infectious disease caused by the bacterium Borrelia burgdorferi . When untreated, infection may spread to the heart, nervous system, and joints. Cardiac involvement usually manifests as abnormalities of the conduction system and bradycardia. Treatment of Lyme disease is generally effective, with a subset of patients experiencing persistent, sometimes long-term symptoms called posttreatment Lyme disease syndrome.
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29046884/selective-intrathecal-enrichment-of-g1m1-positive-b-cells-in-multiple-sclerosis
#10
Andreas Lossius, Alina Tomescu-Baciu, Trygve Holmøy, Christian A Vedeler, Egil Røsjø, Åslaug R Lorentzen, Ilaria Casetta, Frode Vartdal
Immunoglobulin gamma (IgG) heavy chain genes are associated with susceptibility to multiple sclerosis (MS) and IgG levels in the cerebrospinal fluid (CSF). However, how these variants are implicated in disease mechanisms remains unknown. Here, we show that proliferating plasmablasts expressing the G1m1 allotype of IgG1 are selectively enriched in CSF of G1m1/G1m3 heterozygous MS patients, whereas plasmablasts expressing either G1m1 or G1m3 are evenly distributed in blood. Moreover, there was a preferential intrathecal synthesis of oligoclonal IgG1 of the G1m1 allotype in heterozygous patients, whereas controls with Lyme neuroborreliosis displayed oligoclonal IgG1 of both allotypes...
October 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28987189/diseases-of-the-peripheral-nerves
#11
REVIEW
Istvan Katona, Joachim Weis
This chapter reviews the diseases of the peripheral nerves from a neuropathologic point of view, with a special focus on specific morphologic changes, and includes a summary of the histopathologic methods available for their diagnosis. As the rate of obesity and the prevalence of type 2 diabetes increase, diabetic neuropathy is the most common cause of peripheral neuropathy. Many systemic disorders with metabolic origin, like amyloidosis, hepatic failure, vitamin deficiencies, uremia, lipid metabolism disorders, and others, can also cause axonal or myelin alterations in the peripheral nervous system...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28972436/chemokine-cxc-ligand-13-in-cerebrospinal-fluid-can-be-used-as-an-early-diagnostic-biomarker-for-lyme-neuroborreliosis-a-meta-analysis
#12
Jiaru Yang, Xinlin Han, Aihua Liu, Fukai Bao, Yun Peng, Lüyan Tao, Mingbiao Ma, Ruolan Bai, Xiting Dai
Lyme neuroborreliosis (LNB), which is the most common neurological manifestation of Lyme disease (LD), seriously impairs both the central and peripheral nervous systems. Current LNB diagnostic methods and criteria are not very effective. Recently, several studies have indicated that a high concentration of the chemokine CXC ligand 13 (CXCL13) in cerebrospinal fluid (CSF) could be used as a new biomarker for the diagnosis of LNB. Thus, we carried out a meta-analysis to systematically analyze the data from these studies to evaluate the value of CXCL13 as an LNB biomarker...
October 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28948805/neuroborreliosis-in-patients-hospitalised-for-lyme-borreliosis-in-the-czech-republic-in-2003-2013
#13
B Kříž, M Malý, M Daniel
STUDY OBJECTIVE: The objective was to analyse and evaluate a cohort of Lyme borreliosis (LB) patients with neuroborreliosis (LNB) hospitalised in the Czech Republic in 2003-2013. MATERIAL AND METHODS: Data analysed in this study were obtained from the National Register of Hospitalised Patients, which is a nationwide population register maintained at the Institute of Health Information and Statistics of the Czech Republic. Data collection from all departments of bed care establishments are regularly processed every year...
2017: Epidemiologie, Mikrobiologie, Imunologie
https://www.readbyqxmd.com/read/28867633/borrelia-burgdorferi-basic-membrane-protein-a-could-induce-chemokine-production-in-murine-microglia-cell-line-bv2
#14
Hua Zhao, Aihua Liu, Yuhui Cui, Zhang Liang, Bingxue Li, Fukai Bao
Lyme neuroborreliosis is a nervous system infectious disease caused by Borrelia burgdorferi (B. burgdorferi). It has been demonstrated that cytokines induced by B. burgdorferi are related to Lyme neuroborreliosis. Microglia is known as a key player in the immune responses that occur within the central nervous system. In response to inflammation, it will be activated and generate cytokines and chemokines. Experiments in vitro cells have showed that B. Burgdorferi membrane protein A (BmpA), a major immunogen of B...
October 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28859668/cerebrospinal-fluid-cxcl13-as-a-diagnostic-marker-of-neuroborreliosis-in-children-a-retrospective-case-control-study
#15
M M Remy, N Schöbi, L Kottanattu, S Pfister, A Duppenthaler, F Suter-Riniker
BACKGROUND: Lyme neuroborreliosis (LNB) is a frequent manifestation of Lyme disease in children and its current diagnosis has limitations. The elevation of the chemokine CXCL13 in the cerebrospinal fluid (CSF) of adult patients with LNB has been demonstrated and suggested as a new diagnostic marker. Our aim was to evaluate this marker in the CSF of children with suspected LNB and to determine a CXCL13 cut-off concentration that would discriminate between LNB and other central nervous system (CNS) infections...
August 31, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28736624/lyme-and-dopaminergic-function-hypothesizing-reduced-reward-deficiency-symptomatology-by-regulating-dopamine-transmission
#16
Kenneth Blum, Edward J Modestino, Marcelo Febo, Bruce Steinberg, Thomas McLaughlin, Lyle Fried, David Baron, David Siwicki, Rajendra D Badgaiyan
The principal vector of Lyme disease in the United States is Ixodes scapularis: black legged or deer ticks. There is increased evidence that those infected may be plagued by anxiety or depression as well. Researchers have identified transcripts coding for two putative cytosolic sulfotransferases in these ticks, which recognized phenolic monoamines as their substrates. It is hypothesized that protracted Lyme disease sequelae may be due to impairment of dopaminergic function of the brain reward circuitry. The subsequent recombinant proteins exhibited sulfotransferase function against two neurotransmitters: dopamine and octopamine...
May 2017: Journal of Systems and Integrative Neuroscience
https://www.readbyqxmd.com/read/28730326/infectious-diseases-causing-autonomic-dysfunction
#17
REVIEW
Francisco Javier Carod-Artal
OBJECTIVES: To review infectious diseases that may cause autonomic dysfunction. METHODS: Review of published papers indexed in medline/embase. RESULTS: Autonomic dysfunction has been reported in retrovirus (human immunodeficiency virus (HIV), human T-lymphotropic virus), herpes viruses, flavivirus, enterovirus 71 and lyssavirus infections. Autonomic dysfunction is relatively common in HIV-infected patients and heart rate variability is reduced even in early stages of infection...
February 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28566141/bibrachial-plegia-due-to-lyme-radiculopoliomyelitis-myelitis
#18
Feras Akbik, Marcelo Matiello, Amanda Piquet, Tracey Cho, Adam Cohen, Nagagopal Venna
Nervous system involvement occurs in up to 15% of patients with Lyme disease, most commonly manifested as cranial neuropathy, lymphocytic meningitis, and or radiculoneuritis. We describe a patient with subacute radiculopoliomyelitis-myelitis matching the selective involvement of the anterior horns and roots of the cervical spinal cord seen on MRI and on electrodiagnostic studies. We demonstrate positive CSF Lyme antibodies and document a near-complete recovery with antibiotics. This case highlights the importance of recognizing an atypical presentation of Lyme disease in the setting of initial radiculitis and or myelitis, particularly given the potential for favorable outcomes with appropriate treatment...
July 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28473801/cerebrovascular-manifestations-of-lyme-neuroborreliosis-a-systematic-review-of-published-cases
#19
REVIEW
Adam Garkowski, Joanna Zajkowska, Agata Zajkowska, Alina Kułakowska, Olga Zajkowska, Bożena Kubas, Dorota Jurgilewicz, Marcin Hładuński, Urszula Łebkowska
BACKGROUND: Lyme neuroborreliosis (LNB) is a disease caused by spirochete Borrelia burgdorferi, involving the nervous system. It usually manifests as lymphocytic meningoradiculitis, but in rare cases, it can also lead to cerebrovascular complications. We aimed to perform a systematic review of all reported cases of LNB complicated by central nervous system vasculitis and stroke or transient ischemic attack (TIA). MATERIALS AND METHODS: We conducted a systematic review of literature between May 1987 and December 2016 with patients who presented with cerebrovascular course of LNB...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28378969/estimation-of-cognitive-and-affective-disorders-occurrence-in-patients-with-lyme-borreliosis
#20
Barbara Oczko-Grzesik, Lucjan Kępa, Monika Puszcz-Matlińska, Robert Pudło, Anna Żurek, Teresa Badura-Głąbik
INTRODUCTION AND OBJECTIVE: Lyme borreliosis (LB) is a disease caused by the bacteria Borrelia burgdorferi. The most common symptoms are related to the skin, musculo-scelatal system, central and peripheral nervous system, rarely to the heart muscle and the eye, and may occur in the multistage course of the disease. LB may additionally be accompanied by psychopathological symptoms. The aim of the study is estimation of the cognitive and affective disorders occurence in patients with LB...
March 1, 2017: Annals of Agricultural and Environmental Medicine: AAEM
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