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Nervous system lyme disease

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https://www.readbyqxmd.com/read/27885483/neuroborreliosis
#1
John J Halperin
Appropriate, critical application of evidence-based diagnostic criteria enables both a clear definition of what constitutes neuroborreliosis-nervous system infection with Borrelia burgdorferi sensu stricto in the US, B garinii and less commonly B. afzelii and other species in Europe-and recognition that this disorder is quite similar in Europe and the US. Most commonly evidenced by lymphocytic meningitis and/or multifocal inflammation of the peripheral (common; cranial neuropathy, radiculopathy, mononeuropathy multiplex) or central (rare) nervous system, it is readily diagnosed and highly antibiotic responsive...
November 24, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27883377/borrelia-burgdorferi-%C3%A2-morphological-structure-and-motility-as-adaptation-for-transmission-and-survival-in-the-habitat-of-a-tick-vertebrate-setup
#2
Paweł Penza, Anna Moniuszko-Malinowska, Piotr Czupryna, Sławomir Pancewicz, Joanna Zajkowska
Lyme borreliosis is a multisystem chronic disease caused by Borrelia burgdorferi sensu lato (s.l.) spirochete transmitted by Ixodes. This bacterium has a remarkable ability to survive in tick-vertebrate setup. Its infection causes diagnostic and clinical difficulties. It was distinguished as a separate disease entity over 30 years ago. Observations made by Steere et al. proved to be a milestone since they found correlation between the occurrence of skin and joint lesions with tick bites. Further studies showed that the disease affects not only joints and skin, but also nervous and circulatory systems...
2016: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/27855040/claims-based-diagnostic-patterns-of-patients-evaluated-for-lyme-disease-and-given-extended-antibiotic-therapy
#3
Yi-Ju Tseng, Alfred DeMaria, Donald A Goldmann, Kenneth D Mandl
BACKGROUND: A Lyme disease (LD) diagnosis can be far from straightforward, particularly if erythema migrans does not develop or is not noticed. Extended courses of antibiotics for LD are not recommended, but their use is increasing. We sought to elucidate the patient patterns toward a diagnosis of LD, hypothesizing that a subset of patients ultimately receiving extended courses antibiotics may be symptomatic for an extended period before the first LD diagnosis. METHODS: Claims submitted to a nationwide U...
November 17, 2016: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/27847963/-challenge-of-neuroborreliosis
#4
A Spreer, S Rauer, H Wilking, V Fingerle
Lyme borreliosis is the most frequent tick-borne infection in Europe. It is a multisystemic disease affecting the skin, joints, heart, in rare cases the eyes and regularly the nervous system. Taking current clinical and microbiological guidelines into account, neuroborreliosis can in general be diagnosed and treated successfully. An appropriate guideline-conform antibiotic treatment is effective and in most cases recovery from acute neuroborreliosis is complete. Nevertheless, the evidence base regarding pharmacological treatment needs reform and improvement...
November 15, 2016: Der Nervenarzt
https://www.readbyqxmd.com/read/27832501/phospholipidomic-analysis-reveals-changes-in-sphingomyelin-and-lysophosphatidylcholine-profiles-in-plasma-from-patients-with-neuroborreliosis
#5
W Łuczaj, P Domingues, M R Domingues, S Pancewicz, E Skrzydlewska
In recent years, the number of patients suffering from Lyme Disease (LD) has significantly increased. The most dangerous manifestation of LD is neuroborreliosis associated with invasion of the central nervous system by Borrelia burgdorferi. Phospholipids (PL) and their metabolites are involved in inflammation, which plays a dominant, but still unclear, role in the pathogenesis of neuroborreliosis. We analyzed the plasma PL profiles of neuroborreliosis patients (n = 8) and healthy volunteers (n = 8) using a lipidomic approach...
November 10, 2016: Lipids
https://www.readbyqxmd.com/read/27744511/actin-dependent-regulation-of-borrelia-burgdorferi-phagocytosis-by-macrophages
#6
Xenia Naj, Stefan Linder
The spirochete Borrelia burgdorferi is the causative agent of Lyme disease, a multisystemic disorder affecting primarily skin, nervous system, and joints. If an infection with Borrelia proceeds unchecked, the disease can also enter a chronic stage, leading to the development of neuroborreliosis or cardiac arrhythmia. Successful elimination of B. burgdorferi by the host immune system is thus decisive for the positive outcome of a respective infection. Accordingly, host immune cells such as macrophages and dendritic cells have to be able to efficiently internalize and degrade infecting spirochetes...
October 16, 2016: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/27719999/epidemiology-of-lyme-neuroborreliosis
#7
David S Younger
Lyme disease is caused by the bacterium Borrelia burgdorferi and is transmitted to humans through the bite of infected blacklegged ticks. According to the Centers for Disease Control and Prevention, it is the most commonly reported vector-borne illness and the fifth most common disease in the National Notifiable Diseases Surveillance System. If left untreated, infection disseminates to the nervous system. The nonhuman primate model of Lyme disease of the nervous system, or Lyme neuroborreliosis, accurately mimics the aspects of the human illness...
November 2016: Neurologic Clinics
https://www.readbyqxmd.com/read/27667704/identification-and-functional-characterization-of-a-pyrokinin-neuropeptide-receptor-in-the-lyme-disease-vector-ixodes-scapularis
#8
Kinsi Gondalia, Anam Qudrat, Brigida Bruno, Janet Fleites Medina, Jean-Paul V Paluzzi
Pyrokinin-related peptides are pleiotropic factors that are defined by their conserved C-terminal sequence FXPRL-NH2. The pyrokinin nomenclature derives from their originally identified myotropic actions and, as seen in some family members, a blocked amino terminus with pyroglutamate. The black-legged tick, Ixodes scapularis, is well known as a vector of Lyme disease and various other illnesses; however, in comparison to blood-feeding insects, knowledge on its physiology (along with other Ixodid ticks) is rather limited...
December 2016: Peptides
https://www.readbyqxmd.com/read/27618323/white-matter-diseases-with-radiologic-pathologic-correlation
#9
Nicolae Sarbu, Robert Y Shih, Robert V Jones, Iren Horkayne-Szakaly, Laura Oleaga, James G Smirniotopoulos
White matter diseases include a wide spectrum of disorders that have in common impairment of normal myelination, either by secondary destruction of previously myelinated structures (demyelinating processes) or by primary abnormalities of myelin formation (dysmyelinating processes). The pathogenesis of many white matter diseases remains poorly understood. Demyelinating disorders are the object of this review and will be further divided into autoimmune, infectious, vascular, and toxic-metabolic processes. Autoimmune processes include multiple sclerosis and related diseases: tumefactive demyelinating lesions, Balo concentric sclerosis, Marburg and Schilder variants, neuromyelitis optica (Devic disease), acute disseminated encephalomyelitis, and acute hemorrhagic leukoencephalopathy (Hurst disease)...
September 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27478852/texas-occurrence-of-lyme-disease-and-its-neurological-manifestations
#10
Jad A Dandashi, Damir Nizamutdinov, Samantha Dayawansa, Ekokobe Fonkem, Jason H Huang
Today, Lyme disease is the most commonly reported tick-borne disease in the United States and Europe. The culprits behind Lyme disease are the Borrelia species of bacteria. In the USA, Borrelia burgdorferi causes the majority of cases, while in Europe and Asia Borrelia afzelii and Borrelia garinii carry the greatest burden of disease. The clinical manifestations of Lyme disease have been identified as early localized, early disseminated, and late chronic. The neurological effects of Lyme disease include both peripheral and central nervous systems involvement, including focal nerve abnormalities, cranial neuropathies, painful radiculoneuritis, meningitis, and/or toxic metabolic encephalopathy, known as Lyme encephalopathy...
June 2016: Journal of Neuroinfectious Diseases
https://www.readbyqxmd.com/read/27411423/a-presentation-of-lyme-disease-pseudotumor-cerebri
#11
Burcu Şahin, Faruk İncecik, Özlem M Hergüner, Derya Alabaz, Şeyda Beşen
Lyme disease is caused by a tick-transmitted spirochete, B. burgdorferi. It can present with both central and peripheral nervous system manifestations, including aseptic meningitis, meningoencephalitis, Bell's palsy and other cranial neuropathies, radiculoneuritis, and myelitis. However, pseudotumor cerebri associated with Lyme disease is rare. Here, we report a eight-year-old girl with the unusual manifestation of pseudotumor cerebri associated Lyme disease.
September 2015: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27107653/cimetidine-as-a-novel-adjunctive-treatment-for-early-stage-lyme-disease
#12
Justin Shemenski
Lyme disease, caused by the spirochete Borrelia burgdorferi (Bb), is the most common vector-borne illness in the United States. It is a complex disease which may affect the skin, joints, heart, eyes, and central nervous system. Prompt diagnosis and treatment is curative in most instances. However, a significant percentage of patients experience ongoing symptoms after treatment. Currently, there is much controversy regarding the diagnosis, pathophysiology, and treatment of Lyme disease. Pathogen persistence despite treatment lies at the heart of this debate...
April 9, 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27000820/-post-lyme-disease-syndrome
#13
REVIEW
Justyna Błaut-Jurkowska, Marcin Jurkowski
Lyme disease is a chronic infectious disease caused by the bacteria, spirochete of the Borrelia type. Skin, nervous system, musculoskeletal system and heart may be involved in the course of the disease. The prognosis for properly treated Lyme disease is usually good. However, in about 5% of patients so called Post-Lyme disease syndrome (PLSD) develops. It is defined as a syndrome of subjective symptoms persisting despite proper treatment of Borrelia burgdorferi infection. The most common symptoms include: fatigue, muscle and joint pain, and problems with memory and concentration...
February 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/26953086/unusual-presentation-of-unilateral-isolated-probable-lyme-optic-neuritis
#14
Ahmet Z Burakgazi, Carl S Henderson
Optic neuritis (ON) is one of the most common manifestations of central nervous system involvement caused by various etiologies. Lyme ON is an exceedingly rare ocular manifestation of Lyme disease (LD) and only a few cases have been published in the literature. Lyme ON is very rare but should be included in the differential diagnosis in unexplained cases, particularly in Lyme endemic areas. Careful and detailed examination and investigation are warranted to make the diagnosis. We report this case to increase awareness of clinicians to include Lyme disease in differential diagnosis of ON for unexplained cases of ON...
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/26633793/appendix-d-summary-of-evidence-based-guideline-for-clinicians-treatment-of-nervous-system-lyme-disease
#15
(no author information available yet)
No abstract text is available yet for this article.
December 2015: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/26633792/appendix-c-practice-parameter-diagnosis-of-patients-with-nervous-system-lyme-borreliosis-lyme-disease
#16
(no author information available yet)
No abstract text is available yet for this article.
December 2015: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/26633786/lyme-neuroborreliosis
#17
REVIEW
Adriana R Marques
PURPOSE OF REVIEW: Lyme disease, caused by the spirochete Borrelia burgdorferi, is the most common tick-borne illness in the United States and Europe. Lyme disease usually begins with the characteristic skin lesion, erythema migrans, at the site of the tick bite. Following hematogenous dissemination, neurologic, cardiac, and/or rheumatologic involvement may occur. Neurologic involvement occurs in up to 15% of untreated B. burgdorferi infection and neurologists should be familiar with its diagnosis and management...
December 2015: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/26377699/nervous-system-lyme-disease-chronic-lyme-disease-and-none-of-the-above
#18
REVIEW
John J Halperin
Lyme borreliosis, infection with the tick-borne spirochete Borrelia burgdorferi sensu lato, causes nervous system involvement in 10-15 % of identified infected individuals. Not unlike the other well-known spirochetosis, syphilis, infection can be protracted, but is microbiologically curable in virtually all patients, regardless of disease duration. Diagnosis relies on 2-tier serologic testing, which after the first 4-6 weeks of infection is both highly sensitive and specific. After this early, acute phase, serologic testing should rely only on IgG reactivity...
March 2016: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/26344766/er-coordinated-activities-of-rab22a-and-rab5a-drive-phagosomal-compaction-and-intracellular-processing-of-borrelia-burgdorferi-by-macrophages
#19
Xenia Naj, Stefan Linder
Borrelia burgdorferi is the causative agent of Lyme disease, a multisystemic disorder affecting the skin, joints, and nervous system. Macrophages and dendritic cells counteract Borrelia dissemination through internalization and degradation of spirochetes. We now show that Borrelia internalization by primary human macrophages involves uptake and compaction into Rab22a-positive phagosomes that are in close contact with Rab5a-positive vesicles. Compaction of borreliae involves membrane extrusion from phagosomes, is driven by Rab22a and Rab5a activity, and is coordinated by ER tubules forming contact sites of Rab22a phagosomes with Rab5a vesicles...
September 22, 2015: Cell Reports
https://www.readbyqxmd.com/read/26343489/cerebrospinal-fluid-cytology-of-lyme-neuroborreliosis-a-report-of-3-cases-with-literature-review
#20
Juan Xing, Lisa Radkay, Sara E Monaco, Christine G Roth, Liron Pantanowitz
Lyme disease can affect the central nervous system causing a B-cell-predominant lymphocytic pleocytosis. Since most reactions to infection in the cerebrospinal fluid (CSF) are typically T-cell predominant, a B-cell-predominant lymphocytosis raises concern for lymphoma. We present 3 Lyme neuroborreliosis cases in order to illustrate the challenging cytomorphological and immunophenotypic features of their CSF specimens. Three male patients who presented with central nervous system manifestations were diagnosed with Lyme disease...
2015: Acta Cytologica
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