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https://www.readbyqxmd.com/read/28655212/do-comorbidities-influence-help-seeking-for-cancer-alarm-symptoms-a-population-based-survey-in-england
#1
Theodosia Salika, Georgios Lyratzopoulos, Katriina L Whitaker, Jo Waller, Cristina Renzi
Background: We examined associations between different chronic morbidities and help-seeking for possible cancer symptoms. Methods: Postal survey of individuals aged >50 years in England. Participants could report prior morbidities in respect of 12 pre-defined conditions. Among patients experiencing possible cancer symptoms we examined associations between specific morbidities and self-reported help-seeking (i.e. contacted versus not contacted a GP) for each alarm symptom using regression analyses...
June 24, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28655127/depression-screening-by-physical-therapists-practices-beliefs-barriers
#2
Patricia Fay, Susan L Edmond, Julia K Baron, Michelle Joshi
BACKGROUND: Depression, a common comorbidity encountered in physical therapy (PT) practice, negatively impacts outcomes. There is limited knowledge of PT practice patterns relative to screening for depression. OBJECTIVE: Objectives were to describe beliefs regarding depression, and identify practice patterns and perceived barriers regarding screening for depression among APTA Board Certified Orthopedic Clinical Specialist (OCS) PTs. METHODS: Surveys were distributed to all PT OCSs in the US; 416 responses were analyzed...
June 2, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28655095/-efficacy-and-prognostic-analysis-of-98-cases-of-relapsed-refractory-diffuse-large-b-cell-lymphoma-treated-with-second-line-regimens
#3
M C Zhang, Y Qian, J Hao, Z Y Liu, W L Zhao, L Wang
Objective: To evaluate the efficacy and prognostic factors of second-line regimens for patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL). Methods: A retrospective analysis was performed in 98 patients with relapsed/refractory DLBCL who were treated with salvage regimens in Rui Jin Hospital from July 2004 to June 2016. Overall response rate (ORR) was evaluated after all treatment finished. Overall survival (OS) was analyzed by Kaplan-Meier method and multivariate by Cox proportional hazards models...
June 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28655076/-diagnosis-and-treatment-strategy-for-clinical-complete-responders-after-chemoradiotherapy-for-rectal-cancer-is-watch-and-wait-policy-safe
#4
H W Yao, Y H Liu
Neo-adjuvant chemoradiotherapy (NACRT) combined with total mesorectal excision (TME) surgery is the main treatment for locally advanced middle-low rectal cancer, and NACRT significantly improves the local control rate of rectal cancer. According to the current guidelines, patients who receive clinical complete response (cCR) after NACRT are recommended for treatment with TME surgery. A few studies have shown that the watch-and-wait (WAW) policy is safe and could ensure anorectal function and quality of life in patients with cCR...
July 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28654872/the-effects-of-using-answer-sheets-on-reported-drug-use-and-data-quality-in-a-classroom-survey-a-cluster-randomized-study
#5
Alvaro Castillo-Carniglia, Esteban Pizarro, José D Marín, Nicolás Rodríguez, Carolina Casas-Cordero, Magdalena Cerdá
BACKGROUND: We compare self-reported prevalence of drug use and indicators of data quality from two different response modes (with and without an independent answer sheet for recording responses) in a survey conducted in 2015 among secondary school students. METHODS: Stratified cluster-randomized study conducted among students in grades 8-12 from public, private and subsidized schools in Chile (N=2317 students in 122 classes). Measurements included were: percentage reporting substance use (tobacco, alcohol, marijuana, cocaine, ecstasy); number of inconsistent responses; number of item nonresponses; percentage of extreme reports of drug use; percentage reporting using the nonexistent drug, relevón; and completion times...
June 20, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28654822/gender-and-the-structure-of-self-rated-health-across-the-adult-life-span
#6
Anna Zajacova, Snehalata Huzurbazar, Megan Todd
Despite the widespread use of self-rated health (SRH) in population health studies, the meaning of this holistic health judgment remains an open question. Gender differences in health, an issue of utmost importance in population research and policy, are often measured with SRH; the comparisons could be biased if men and women differ in how they form their health judgment. The aim of this study is to examine whether men and women differ in how health inputs predict their health rating across the adult life span...
June 16, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28654676/silver-bighead-and-common-carp-orient-to-acoustic-particle-motion-when-avoiding-a-complex-sound
#7
Daniel P Zielinski, Peter W Sorensen
Behavioral responses of silver carp (Hypopthalmichthys molitrix), bighead carp (H. nobilis), and common carp (Cyprinus carpio) to a complex, broadband sound were tested in the absence of visual cues to determine whether these species are negatively phonotaxic and the roles that sound pressure and particle motion might play mediating this response. In a dark featureless square enclosure, groups of 3 fish were tracked and the distance of each fish from speakers and their swimming trajectories relative to sound pressure and particle acceleration were analyzed before, and then while an outboard motor sound was played...
2017: PloS One
https://www.readbyqxmd.com/read/28654651/herpes-simplex-virus-1-and-2-educational-assessment-of-young-adults-in-rural-southwest-virginia
#8
Shantal S Hover, Andrea S Bertke
PURPOSE: Herpes simplex virus 2 (HSV-2) causes genital herpes, one of the most common sexually transmitted infections (STIs) in the U.S. HSV-1, commonly associated with cold sores, is increasing as a cause of genital herpes. Abstinence-only sexual health classes, commonly taught in Virginia, generate young adults who are under-educated in sexual health, increasing STI risks. College students in southwest Virginia were surveyed to assess comprehensiveness of high school health education regarding HSV-1 and HSV-2 and to identify students' preferred methods for STI education...
2017: PloS One
https://www.readbyqxmd.com/read/28654590/the-ideal-buttock-size-a-sociodemographic-morphometric-evaluation
#9
Paul I Heidekrueger, Sammy Sinno, Neil Tanna, Caroline Szpalski, Sabrina Juran, Daniel Schmauss, Denis Ehrl, Reuben Ng, Milomir Ninkovic, P Niclas Broer
BACKGROUND: Perception of beauty is influenced by geographic, ethnic, cultural, and demographic factors. However, objective measurements remain the foundation for aesthetic evaluations. In the quest to better define the "ideal" female buttock, this study assumes interdependence among variables such as country of residence, sex, age, occupation, and aesthetic perception, yielding a waist-to-hip ratio that appears most pleasing across most cultures and geographic locations. METHODS: An online survey was designed...
July 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28654555/the-experience-of-pain-dismissal-in-adolescence
#10
Ellen K Defenderfer, Kate Bauer, Eva Igler, Julia A Uihlein, W Hobart Davies
CONTEXT: Pain in adolescence has psychosocial effects lasting into adulthood, including increased likelihood of pain in adulthood and higher rates of depression and anxiety. Many adolescents with chronic pain describe skepticism of pain reports, but this has not yet been evaluated in a sample of typically developing adolescents. OBJECTIVE: The current study sought to describe the experience of perceived pain dismissal during adolescence in a community sample. METHOD: Nearly two-thousand (1931) emerging adults were recruited from the community and answered open-ended questions regarding whether they had experienced dismissal of their pain in adolescence, who dismissed their pain, characteristics of the dismisser, and what that experience was like...
June 16, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28654541/caring-for-older-surgical-patients-contemporary-attitudes-knowledge-practices-and-needs-of-general-surgeons-and-residents
#11
Tyler R Chesney, George Pang, Najma Ahmed
OBJECTIVE: To gain contemporary insights from residents and surgeons regarding the care of older surgical patients. BACKGROUND DATA: With worldwide aging, efforts over the past decade have attempted to increase surgeons' abilities to care for older adults, but a current understanding of attitudes, knowledge, practices, and needs is missing. METHODS: Between July 2016 and September 2016 we conducted a national Web-based survey sampling all general surgery residents and academic general surgeons using a questionnaire designed and tested for this purpose...
June 26, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28654439/unusual-cause-of-thoracic-wall-pain-in-a-kayaker-a-case-report
#12
Guy Morgan Evans, Gurjit Bhogal
Chest wall injuries are common in paddle-based sports such as kayaking. We present the case of a 46-year-old amateur kayaker who presented with signs and symptoms in keeping with a rib stress response or fracture. The patient failed to respond to conservative management and subsequent imaging revealed an obstructed left kidney with associated hydronephrosis. This case report highlights the importance of considering the wider differential diagnoses when managing athletes participating in paddle-based sports, especially when symptoms fail to settle with appropriate conservative management...
June 22, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28654437/self-reported-physical-activity-level-in-student-athletes-at-preparticipation-physical-evaluations
#13
Amy E Valasek, Madison Bieganski, Jana Desrochers, Julie Young
OBJECTIVE: Quantify physical activity in healthy student athletes. DESIGN: Cross-sectional survey. SETTING: Five Central Ohio schools during mass preparticipation physicals. PARTICIPANTS: Three hundred sixty-five children between the ages 10 and 18 years. INDEPENDENT VARIABLES: Days per week of moderate to vigorous physical activity (MVPA), minutes per day of MVPA, and number of activities. MAIN OUTCOME MEASURES: Minutes per week of MVPA...
June 22, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28654420/lineage-commitment-of-embryonic-cells-involves-mek1-dependent-clearance-of-pluripotency-regulator-ventx2
#14
Pierluigi Scerbo, Leslie Marchal, Laurent Kodjabachian
During early embryogenesis, cells must exit pluripotency and commit to multiple lineages in all germ-layers. How this transition is operated in vivo is poorly understood. Here, we report that MEK1 and the Nanog-related transcription factor Ventx2 coordinate this transition. MEK1 was required to make Xenopus pluripotent cells competent to respond to all cell fate inducers tested. Importantly, MEK1 activity was necessary to clear the pluripotency protein Ventx2 at the onset of gastrulation. Thus, concomitant MEK1 and Ventx2 knockdown restored the competence of embryonic cells to differentiate...
June 27, 2017: ELife
https://www.readbyqxmd.com/read/28654330/early-transcriptional-responses-during-heat-stress-in-the-coral-acropora-hyacinthus
#15
Nikki Traylor-Knowles, Noah H Rose, Elizabeth A Sheets, Stephen R Palumbi
Corals respond to heat pulses that cause bleaching with massive transcriptional change, but the immediate responses to stress that lead up to these shifts have never been detailed. Understanding these early signals could be important for identifying the regulatory mechanisms responsible for bleaching and how these mechanisms vary between more and less resilient corals. Using RNA sequencing (RNAseq) and sampling every 30 minutes during a short-term heat shock, we found that components of the transcriptome were significantly upregulated within 90 min and after a temperature increase of +2 °C...
April 2017: Biological Bulletin
https://www.readbyqxmd.com/read/28654327/a-new-facet-of-vitamin-b12-gene-regulation-by-cobalamin-based-photoreceptors
#16
S Padmanabhan, Marco Jost, Catherine L Drennan, Montserrat Elías-Arnanz
Living organisms sense and respond to light, a crucial environmental factor, using photoreceptors, which rely on bound chromophores such as retinal, flavins, or linear tetrapyrroles for light sensing. The discovery of photoreceptors that sense light using 5'-deoxyadenosylcobalamin, a form of vitamin B12 that is best known as an enzyme cofactor, has expanded the number of known photoreceptor families and unveiled a new biological role of this vitamin. The prototype of these B12-dependent photoreceptors, the transcriptional repressor CarH, is widespread in bacteria and mediates light-dependent gene regulation in a photoprotective cellular response...
June 20, 2017: Annual Review of Biochemistry
https://www.readbyqxmd.com/read/28654254/development-strategies-and-prospects-of-nano-based-smart-pesticide-formulation
#17
Xiang Zhao, Haixin Cui, Yan Wang, Changjiao Sun, Bo Cui, Zhanghua Zeng
Pesticides are important inputs for enhancing crop productivity and preventing major biological disasters. However, more than 90% of pesticides run off into the environment and residue in agricultural products in process of application, due to the disadvantages of conventional pesticide formulation such as use of harmful solvent, poor dispersion, dust drift, etc. In recent years, using nanotechnology to create novel formulations has shown great potential in improving the efficacy and safety of pesticides. The development of nano-based pesticide formulation aims at precise release of necessary and sufficient amounts of their active ingredients, in responding to environmental triggers and biological demands through controlled release mechanisms...
June 27, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28654162/the-importance-of-person-centred-care-and-co-creation-of-care-for-the-well-being-and-job-satisfaction-of-professionals-working-with-people-with-intellectual-disabilities
#18
Leontine van der Meer, Anna Petra Nieboer, Harry Finkenflügel, Jane Murray Cramm
BACKGROUND: Person-centred care and co-creation of care (productive interactions between clients and professionals) are expected to lead to better outcomes for clients. Professionals play a prominent role in the care of people with intellectual disabilities at residential care facilities. Thus, person-centred care and co-creation of care may be argued to lead to better outcomes for professionals as well. This study aimed to identify relationships of person-centred care and co-creation of care with the well-being and job satisfaction of professionals working with people with intellectual disabilities (PWID)...
February 3, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28654150/severe-hidradenitis-suppurativa-responding-to-treatment-with-secukinumab-a-case-report
#19
L Thorlacius, P Theut Riis, G B E Jemec
An inappropriate immunologic response to an unknown antigen has been suggested to play a role in the pathogenesis of Hidradenitis suppurativa (HS). Studies have identified elevated levels of several proinflammatory cytokines, including IL-17A and TNF-α, nominating these as possible therapeutic targets.(1) Secukinumab is an Il-17A monoclonal antibody, which binds to Il-17A and inhibits the cytokine interaction with the Il-17 receptors, inhibiting the inflammatory cascade. Here we report on a case of a 47-year-old man, with Hurley Stage III lesions at the neck, axillae, breasts, genital skin and buttocks, who had experienced only temporary benefit from different medical treatments over the years...
June 27, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28654093/an-epigenome-wide-dna-methylation-study-of-ptsd-and-depression-in-world-trade-center-responders
#20
P-F Kuan, M A Waszczuk, R Kotov, C J Marsit, G Guffanti, A Gonzalez, X Yang, K Koenen, E Bromet, B J Luft
Previous epigenome-wide association studies (EWAS) of posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) have been inconsistent. This may be due to small sample sizes, and measurement and tissue differences. The current two EWA analyses of 473 World Trade Center responders are the largest to date for both PTSD and MDD. These analyses investigated DNA methylation patterns and biological pathways influenced by differentially methylated genes associated with each disorder. Methylation was profiled on blood samples using Illumina 450 K Beadchip...
June 27, 2017: Translational Psychiatry
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