Wanwisa Promsote, Kesara Chumpolkulwong, Thomas Musich, Michael J Corley, Lishomwa C Ndhlovu, Jumpol Sopanaporn, Dutsadee Inthawong, Panupat Nadee, Decha Silsorn, Siwikorn Sirisrisopa, Sakda Wongsawanonkul, Matthew S Parsons, Jessica Cowden, Rawiwan Imerbsin, Luis Lugo-Roman, Sandhya Vasan, Denise C Hsu
Sleep deprivation in humans is associated with both cognitive impairment and immune dysregulation. An animal model of neuropathogenesis may provide insight to understand the effects of sleep deprivation on the brain. Human neurocognition is more closely mirrored by nonhuman primates (NHP) than other animals. As such, we developed an NHP model to assess the impact of sleep deprivation on neurocognition and markers of systemic immune activation. Six male rhesus macaques underwent three rounds of sleep deprivation (48 h without sleep) at days 0, 14, and 28...
November 2023: Brain, behavior, & immunity health