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https://www.readbyqxmd.com/read/28102519/nmdar-encephalitis-following-herpes-simplex-virus-encephalitis
#1
REVIEW
Jonathan Galli, Stacey L Clardy, Amanda L Piquet
PURPOSE OF REVIEW: Herpes simplex virus encephalitis (HSVE) is often associated with significant morbidity and mortality, and despite appropriate treatment with antivirals, worsening of neurological symptoms or relapse occurs in a subset of patients. Recent data suggests that many relapses are likely caused by a secondary immune response, with the N-methyl-D-aspartate receptor (NMDAR) antibody being the most commonly associated autoantibody. We provide a review of the relevant literature, examining the relationship between HSVE and development of autoimmunity...
January 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28102002/pseudoherpetic-transient-acantholytic-dermatosis-grover-disease-case-series-and-review-of-the-literature
#2
Kiran Motaparthi
Three cases of pseudoherpetic transient acantholytic dermatosis (Grover disease) are presented, followed by a brief review of prior reports. All three patients were above the age of 60 and presented with a pruritic eruption composed of papules with or without vesicles distributed on the trunk. For all three patients, the clinical differential diagnosis included drug eruption but did not include Grover disease; in one patient, the clinical impression included herpesvirus infection. Similar histologic and immunohistochemical findings were demonstrated in all three cases...
January 18, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28101751/fatal-disseminated-neonatal-herpes-simplex-virus-type-1-infection-in-neonates-in-a-forensic-setting
#3
Jia Hao Wu, Sarah Parsons
No abstract text is available yet for this article.
January 19, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28101180/acute-renal-injury-induced-by-valacyclovir-hydrochloride-a-case-report
#4
Yanning Zhang, Yuxi Cong, Yan Teng
Acyclovir has been a frequently used antiviral agent in the clinical treatment of leukemia, acute encephalitis, malignant tumor and herpes simplex. The adverse effects of this drug have been widely described in clinical practice. In the present study, a case of a 35-year-old female patient diagnosed with herpes simplex, who developed acute renal injury following treatment with valacyclovir hydrochloride, is described. Kidney biopsy, light microscopy and laboratory examination were performed, and all findings revealed the signs of evident vacuolar degeneration of capillary endothelial and renal tubular epithelial cells, erythrocyte aggregation in partial renal tubule and microvilli exfoliation from epithelial cells...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28101017/efficacy-of-a-film-forming-medical-device-containing-piroxicam-and-sun-filters-in-the-treatment-of-multiple-actinic-keratosis-lesions-in-a-subject-with-a-history-of-kaposi-sarcoma
#5
Elisabetta Scotti, Salvatore Deledda, Massimo Milani
Actinic keratosis (AK) is considered a premalignant form of skin cancer due to chronic sun exposure. In addition, human papilloma virus (HPV) has been advocated a role in the pathogenesis of this clinical condition. HPV proteins (mainly E6 and E7) seem to act synergistically with ultraviolet (UV) radiation in reducing the defensive mechanisms of keratinocyte apoptosis after UV damage. Data regarding the involvement of other viruses, i.e. human herpes viruses (HHV), in the pathogenesis of AK are so far controversial...
September 2016: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28100832/reporter-gene-imaging-of-targeted-t-cell-immunotherapy-in-recurrent-glioma
#6
Khun Visith Keu, Timothy H Witney, Shahriar Yaghoubi, Jarrett Rosenberg, Anita Kurien, Rachel Magnusson, John Williams, Frezghi Habte, Jamie R Wagner, Stephen Forman, Christine Brown, Martin Allen-Auerbach, Johannes Czernin, Winson Tang, Michael C Jensen, Behnam Badie, Sanjiv S Gambhir
High-grade gliomas are aggressive cancers that often become rapidly fatal. Immunotherapy using CD8(+) cytotoxic T lymphocytes (CTLs), engineered to express both herpes simplex virus type 1 thymidine kinase (HSV1-TK) and interleukin-13 (IL-13) zetakine chimeric antigen receptor (CAR), is a treatment strategy with considerable potential. To optimize this and related immunotherapies, it would be helpful to monitor CTL viability and trafficking to glioma cells. We show that noninvasive positron emission tomography (PET) imaging with 9-[4-[(18)F]fluoro-3-(hydroxymethyl)butyl]guanine ([(18)F]FHBG) can track HSV1-tk reporter gene expression present in CAR-engineered CTLs...
January 18, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28100624/azacytidine-treatment-inhibits-the-progression-of-herpes-stromal-keratitis-by-enhancing-regulatory-t-cell-function
#7
Siva Karthik Varanasi, Pradeep B J Reddy, Siddheshvar Bhela, Ujjaldeep Jaggi, Fernanda Gimenez, Barry T Rouse
: Ocular infection with Herpes Simplex Virus type 1 (HSV-1) sets off an inflammatory reaction in the cornea which leads to both virus clearance as well as chronic lesions that are orchestrated by CD4 T cells. Approaches that enhance the function of regulatory T cells (Treg) and dampen effector T cells can be effective to limit Stromal Keratitis (SK) lesion severity. In this report, we have explored the novel approach of inhibiting DNA methyltransferase activity using 5-Azacytidine (cytosine analog) to limit HSV-1 induced ocular lesions...
January 18, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28100608/herpes-simplex-virus-type-1-ul24-abrogates-dna-sensing-signal-pathway-by-inhibiting-nf-%C3%AE%C2%BAb-activation
#8
Haiyan Xu, Chenhe Su, Angela Pearson, Christopher H Mody, Chunfu Zheng
: Cyclic GMP-AMP synthase (cGAS) is a newly identified DNA sensor that recognizes foreign DNA, including the genome of herpes simplex virus 1 (HSV-1). Upon binding of viral DNA, cGAS produces cyclic GMP-AMP, which interacts with and activates stimulator of interferon genes (STING) to trigger the transcription of anti-viral genes such as type I interferons and production of inflammatory cytokines. HSV-1 UL24 is widely conserved among the herpesviruses family and is essential for efficient viral replication...
January 18, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28100459/clinical-and-pathological-characteristics-of-hiv-and-hhv8-negative-castleman-disease
#9
Li Yu, Meifeng Tu, Jorge Cortes, Zijun Y Xu-Monette, Roberto N Miranda, Jun Zhang, Robert Z Orlowski, Sattva Neelapu, Prajwal C Boddu, Mary A Akosile, Thomas S Uldrick, Robert Yarchoan, L Jeffrey Medeiros, Yong Li, David C Fajgenbaum, Ken H Young
Castleman disease (CD) comprises three poorly-understood lymphoproliferative variants that share several common histopathological features. Unicentric CD (UCD) is localized to a single region of lymph nodes. Multicentric CD (MCD) manifests with systemic inflammatory symptoms and organ dysfunction due to cytokine dysregulation, and involves multiple lymph node regions. Human herpes virus-8 causes MCD (HHV-8-associated MCD) in immunocompromised individuals, such as HIV infected patients. However, greater than 50% MCD cases are HIV and HHV-8 negative, defined as idiopathic (iMCD)...
January 18, 2017: Blood
https://www.readbyqxmd.com/read/28100258/association-between-work-time-loss-and-quality-of-life-in-patients-with-herpes-zoster-a-pooled-analysis-of-the-master-studies
#10
Emmanouil Rampakakis, Melissa Stutz, Kosuke Kawai, Tsen-Fang Tsai, Hee Jin Cheong, Jittima Dhitavat, Alejandro Ortiz-Covarrubias, Miguel Cashat-Cruz, Homero Monsanto, Kelly D Johnson, John S Sampalis, Camilo J Acosta
BACKGROUND: Herpes zoster (HZ) has a significant negative effect on the productive work life of individuals, and has been shown to be responsible for cases of absenteeism, presenteeism and decreased work effectiveness. The aim of this study was to evaluate health utility scores and associated predictors in an actively employed population of Herpes Zoster (HZ) patients with and without work time loss (WTL). METHODS: This was a pooled analysis of the prospective, observational MASTER cohort studies, conducted in 8 countries across North America, Latin America and Asia...
January 18, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28099593/angiosarcoma-in-hiv-negative-patients-is-not-associated-with-hhv-8
#11
João Avancini, José Antonio Sanches, Andre Pires Zanata Cherubim, Renato Pazzini, Cristina Mendes de Oliveira, Laura Masami Sumita, Neusa Yuriko Sakai Valente, Claudio Sergio Pannuti, Cyro Festa
BACKGROUND: Angiosarcoma is an aggressive, malignant neoplasm of vascular or lymphatic origin. Herpes virus 8 (HHV-8) is a member of the herpes family with a tropism for endothelial cells and it has been proven to induce vascular neoplasms, such as Kaposi's sarcoma. The role of HHV-8 in the pathogenesis of angiosarcoma has not been well defined. OBJECTIVE: To investigate the relationship between the presence of HHV-8 and angiosarcoma. METHODS: In this study, the team investigated the relationship between the presence of HHV-8, as determined by polymerase chain reaction, and angiosarcoma, using samples from patients with epidemic Kaposi's sarcoma as controls...
November 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28095879/treatment-seeking-behaviour-and-barriers-to-service-access-for-sexually-transmitted-diseases-among-men-who-have-sex-with-men-in-china-a-multicentre-cross-sectional-survey
#12
Jun-Jie Xu, Yan-Qiu Yu, Qing-Hai Hu, Hong-Jing Yan, Zhe Wang, Lin Lu, Ming-Hua Zhuang, Xi Chen, Ji-Hua Fu, Wei-Ming Tang, Wen-Qing Geng, Yong-Jun Jiang, Hong Shang
BACKGROUND: Delayed or inappropriate treatment for sexually transmitted diseases (STDs) increases the risk of HIV acquisition and may cause other harmful outcomes. However, studies on STD treatment-seeking behaviour and correlated factors in men who have sex with men (MSM) are scarce. This information is crucial for the promotion of STD treatment-seeking behaviour and reduction of HIV transmission among Chinese MSM. METHODS: During 2012-2013, a multicentre cross-sectional study was conducted in 7 Chinese cities...
January 18, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28095500/senp7-potentiates-cgas-activation-by-relieving-sumo-mediated-inhibition-of-cytosolic-dna-sensing
#13
Ye Cui, Huansha Yu, Xin Zheng, Rui Peng, Qiang Wang, Yi Zhou, Rui Wang, Jiehua Wang, Bo Qu, Nan Shen, Qiang Guo, Xing Liu, Chen Wang
Cyclic GMP-AMP (cGAMP) synthase (cGAS, a.k.a. MB21D1), a cytosolic DNA sensor, catalyzes formation of the second messenger 2'3'-cGAMP that activates the stimulator of interferon genes (STING) signaling. How the cGAS activity is modulated remains largely unknown. Here, we demonstrate that sentrin/SUMO-specific protease 7 (SENP7) interacted with and potentiated cGAS activation. The small ubiquitin-like modifier (SUMO) was conjugated onto the lysine residues 335, 372 and 382 of cGAS, which suppressed its DNA-binding, oligomerization and nucleotidyl-transferase activities...
January 17, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28095497/replication-coupled-recruitment-of-viral-and-cellular-factors-to-herpes-simplex-virus-type-1-replication-forks-for-the-maintenance-and-expression-of-viral-genomes
#14
Jill A Dembowski, Sarah E Dremel, Neal A DeLuca
Herpes simplex virus type 1 (HSV-1) infects over half the human population. Much of the infectious cycle occurs in the nucleus of cells where the virus has evolved mechanisms to manipulate host processes for the production of virus. The genome of HSV-1 is coordinately expressed, maintained, and replicated such that progeny virions are produced within 4-6 hours post infection. In this study, we selectively purify HSV-1 replication forks and associated proteins from virus-infected cells and identify select viral and cellular replication, repair, and transcription factors that associate with viral replication forks...
January 17, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28095323/pattern-recognitions-receptors-in-immunodeficiency-disorders
#15
Esameil Mortaz, Ian M Adcock, Payam Tabarsi, Ilad Alavi Darazam, Masoud Movassaghi, Johan Garssen, Hamidreza Jamaati, Aliakbar Velayati
Pattern recognition receptors (PRRs) recognize common microbial or host-derived macromolecules and have important roles in early activation and response of the immune system. Initiation of the innate immune response starts with the recognition of microbial structures called pathogen associated molecular patterns (PAMPs). Recognition of PAMPs is performed by germline-encoded receptors expressed mainly on immune cells termed pattern recognition receptors (PRRs). Several classes of pattern recognition receptors (PRRs) are involved in the pathogenesis of diseases, including Toll-like receptors (TLRs), C-type lectin receptors (CLRs), and Nod-like receptors (NLRs)...
January 14, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28094044/diagnosis-and-treatment-of-acute-retinal-necrosis-a-report-by-the-american-academy-of-ophthalmology
#16
Scott D Schoenberger, Stephen J Kim, Jennifer E Thorne, Prithvi Mruthyunjaya, Steven Yeh, Sophie J Bakri, Justis P Ehlers
PURPOSE: To evaluate the available evidence in peer-reviewed publications about the diagnosis and treatment of acute retinal necrosis (ARN). METHODS: Literature searches of the PubMed and Cochrane Library databases were last conducted on July 27, 2016. The searches identified 216 unique citations, and 49 articles of possible clinical relevance were reviewed in full text. Of these 49 articles, 27 were deemed sufficiently relevant or of interest, and they were rated according to strength of evidence...
January 13, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28093274/a-direct-quantitative-pcr-based-measurement-of-herpes-simplex-virus-susceptibility-to-antiviral-drugs-and-neutralizing-antibodies
#17
Dezső P Virók, Ildikó Eszik, Tímea Mosolygó, Kamil Önder, Valéria Endrész, Katalin Burián
Herpes simplex viruses (HSV) are common human pathogens that can cause painful but benign manifestations and recurrent complaints, but can also cause significant morbidity and mortality on infection of the eye or brain and with disseminated infection of an immunosuppressed patient or a neonate. HSV growth inhibition measurement by plaque or yield reduction is a key task in the development of novel antiviral compounds but the manual methods are very labour intensive. The sensitive and specific PCR technology could be an effective method for quantitation of HSV DNA related to virus replication; however the currently described PCR approaches have a major limitation, namely the requirement of purification of DNA from the infected cells...
January 13, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28093081/the-most-important-questions-in-cancer-research-and-clinical-oncology-question-1-could-the-vertical-transmission-of-human-papilloma-virus-hpv-infection-account-for-the-cause-characteristics-and-epidemiology-of-hpv-positive-oropharyngeal-carcinoma-non-smoking
#18
Joseph T S Wee, Sharon Shuxian Poh
Specific research foci: (1) Mouse models of gamma-herpes virus-68 (γHV-68) and polyomavirus (PyV) infections during neonatal versus adult life. (2) For human papilloma virus (HPV)-positive oropharyngeal carcinoma (OPC)-(a) Asking the question: Is oral sex a powerful carcinogen? (b) Examining the evidence for the vertical transmission of HPV infection. (c) Examining the relationship between HPV and Epstein-Barr virus (EBV) infections and nasopharyngeal cancer (NPC) in West European, East European, and East Asian countries...
January 16, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28091339/association-of-cigarette-smoking-with-a-past-history-and-incidence-of-herpes-zoster-in-the-general-japanese-population-the-shez-study
#19
J Ban, Y Takao, Y Okuno, Y Mori, H Asada, K Yamanishi, H Iso
Few studies have examined the impact of cigarette smoking on the risk for herpes zoster. The Shozu Herpes Zoster (SHEZ) Study is a community-based prospective cohort study over 3 years in Japan aiming to clarify the incidence and predictive and immunological factors for herpes zoster. We investigated the associations of smoking status with past history and incidence of herpes zoster. A total of 12 351 participants provided valid information on smoking status and past history of herpes zoster at baseline survey...
January 16, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28090751/a-safety-checkpoint-to-eliminate-cancer-risk-of-the-immune-evasive-cells-derived-from-human-embryonic-stem-cells
#20
Jingjin He, Zhili Rong, Xuemei Fu, Yang Xu
Human embryonic stem cells (hESCs) hold great promise in the regenerative therapy of many currently untreatable human diseases. One of the key bottlenecks is the immune rejection of hESC-derived allografts by the recipient. To overcome this challenge, we have established new approaches to induce immune protection of hESC-derived allografts through the co-expression of immune suppressive molecules CTLA4-Ig and PD-L1. However, this in turn raises a safety concern of cancer risk because these hESC-derived cells can evade immune surveillance...
January 16, 2017: Stem Cells
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